Composition with effects of reducing weight and dispelling effects of alcohol as well as preparation method and application of composition

Abstract

The invention belongs to the technical field of functional food and traditional Chinese medicine, and particularly relates to a composition with the effects of reducing weight and dispelling the effects of alcohol as well as a preparation method and application thereof. The composition comprises the following raw material components in parts by weight: 35-95 parts of cellulose, 5-55 parts of konjaku flour, 1-5 parts of lance asiabell root, 2-10 parts of Chinese wolfberry fruit, 2-8 parts of soybean, 1-10 parts of hawthorn and 1-5 parts of rhizoma polygonati. The cellulose, the konjaku flour and the medicinal and edible traditional Chinese medicines are prepared into the composition, so that the composition can reduce food absorption, and has remarkable effects of reducing weight and dispelling the effects of alcohol.

Description

Technical Field

[0001] The invention belongs to the technical field of functional foods and traditional Chinese medicines, and specifically relates to a composition with weight loss and hangover relief effects, and a preparation method and application thereof. Background Art

[0002] Weight loss products are constantly innovating, and a variety of new products have been launched to meet the needs of different consumers. For example, from traditional instant tea to emerging functional foods, the types are gradually diversified. However, there are still some problems, such as: (1) Exaggerated effects: Many weight loss products attract consumers by exaggerating their effects, but the actual effects are not as significant as advertised. For example, some products claim that "one pill can produce results", but consumers experience discomfort symptoms such as anorexia, insomnia, and constipation after taking them. In addition, the actual effects of some meal replacement products may deviate from the low fat and low energy they advertise. (2) Incomplete nutrition: Some weight loss foods fail to provide all the nutrients needed by the body, such as high-quality protein and fat, which may lead to malnutrition and affect physical health. (3) Side effects and health risks: Some weight loss products contain unlisted active ingredients or harmful substances, such as fenfluramine and ephedrine, which may cause liver damage. In addition, some enzyme products can cause severe diarrhea. (4) Poor long-term effects: Some rapid weight loss methods often cannot maintain the slimming effect for a long time and may also bring side effects. For example, eating only boiled vegetables and not eating meat, eggs, milk and other foods cannot provide all the nutrients needed by the body, which may lead to malnutrition and affect physical health.

[0003] Furthermore, the weight loss products on the market are relatively simple, and many obese people like to drink alcohol, which causes damage to the liver. There is currently no composition that can both effectively reduce weight and significantly relieve alcohol. Therefore, developing a composition with good weight loss effect, no side effects, obvious alcohol relief effect, simple raw materials, and both medicinal and edible origin is an important direction of research and development in this field. Summary of the invention

[0004] In view of the deficiencies in the prior art, the present invention provides a composition for promoting muscle recovery after exercise, a preparation method and application thereof.

[0005] In order to achieve the purpose of the present invention, the technical solution adopted is as follows:

[0006] A composition with weight loss and hangover relief effects, the raw materials of the composition comprising the following components: cellulose, konjac flour, four-leaf ginseng, wolfberry, soybean, hawthorn and polygonatum.

[0007] Preferably, the raw materials of the composition include the following components by weight: 35-95 parts of cellulose, 5-55 parts of konjac flour, 1-5 parts of four-leaf ginseng, 2-10 parts of wolfberry, 2-8 parts of soybean, 1-10 parts of hawthorn and 1-5 parts of polygonatum.

[0008] Preferably, the raw materials of the composition include the following components by weight: 35-50 parts of cellulose, 30-45 parts of konjac flour, 3-5 parts of four-leaf ginseng, 3-8 parts of wolfberry, 2-6 parts of soybean, 3-7 parts of hawthorn and 1-4 parts of polygonatum.

[0009] Preferably, the raw materials of the composition include the following components by weight: 35-48 parts of cellulose, 32-45 parts of konjac flour, 3-5 parts of four-leaf ginseng, 4-5 parts of wolfberry, 2-5 parts of soybean, 3-7 parts of hawthorn and 2-4 parts of polygonatum.

[0010] The second object of the present invention is to provide a method for preparing the above-mentioned composition, which comprises grinding four-leaf ginseng, wolfberry, soybean, hawthorn and polygonatum into fine powder, and mixing the powder with cellulose and konjac flour.

[0011] The present invention also provides another method for preparing the above composition, comprising the following steps:

[0012] (1) Mix four-leaf ginseng, wolfberry, soybean, hawthorn and polygonatum, add solvent for extraction, and concentrate the extract to obtain a thick paste;

[0013] (2) Mix the thick paste with cellulose and konjac flour.

[0014] Preferably, the solvent in step (1) is water, and the extraction is decoction.

[0015] Preferably, the solvent in step (1) is an ethanol aqueous solution with a volume concentration of 55-75%, and the extraction is a heating reflux extraction.

[0016] Preferably, the extraction times in step (1) are 1-3 times, the time of each extraction is 0.5-2 hours, and the solvent is 5-10 times the total mass of four-leaf ginseng, wolfberry, soybean, hawthorn and polygonatum.

[0017] Preferably, the prepared composition is mixed with pharmaceutically acceptable excipients, dried, and made into granules, tablets or capsules.

[0018] Another object of the present invention is to provide a pharmaceutical preparation, the raw materials of which include the above-mentioned composition or the composition obtained by the above-mentioned preparation method, and pharmaceutically acceptable excipients, and the dosage form of the pharmaceutical preparation is capsule, tablet, granule or gel.

[0019] Another object of the present invention is to provide the use of the above composition or the composition obtained by the preparation method in preparing products with weight loss and alcohol sobering effects.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] (1) The composition prepared by the cellulose, konjac flour and edible Chinese medicine of the present invention can reduce food absorption and has a significant weight loss effect.

[0022] (2) The present invention improves the synergistic effect between the components by controlling the specific types and ratios of the active ingredients of the drug, thereby improving the weight loss effect and having a hangover-relieving effect.

[0023] (3) The Chinese medicinal materials such as Panax notoginseng, Fructus Lycii, Soybean, Hawthorn, Polygonatum sibiricum and the like which are both medicinal and edible can also supplement the human body with vitamins, trace elements and essential amino acids, and prevent the deficiency of vitamins, trace elements and amino acids caused by long-term consumption of cellulose, konjac flour and the like. DETAILED DESCRIPTION

[0024] The present invention is further described below in conjunction with specific embodiments. The following raw materials are all commercially available conventional raw materials, wherein the supplier of cellulose includes but is not limited to Shandong Heda Group Co., Ltd., with the trade name Heda, and the four-leaf ginseng comes from the root of Codonopsis lanceolata Benth.et Hook. of the Campanulaceae family.

[0025] Example 1

[0026] The formula of the composition with weight loss and alcohol sobering effects is shown in Table 1.

[0027] Table 1

[0028]

[0029] The preparation method is as follows:

[0030] (1) Mixing four-leaf ginseng, wolfberry, soybean, hawthorn, and polygonatum with a volume concentration of 65% ethanol solution at a solid-liquid ratio of 1:6 g / mL, reflux extraction twice, each time for 2 hours, filtering the extract, combining the filtrate, recovering the alcohol, and concentrating to obtain a thick paste (specific gravity of 1.25-1.35);

[0031] (2) Mix the thick paste with cellulose and konjac flour and dry it.

[0032] Example 2

[0033] The formula of the composition with weight loss and alcohol sobering effects is shown in Table 2.

[0034] Table 2

[0035]

[0036] The preparation method is as follows:

[0037] Grind four-leaf ginseng, wolfberry, soybean, hawthorn and polygonatum into fine powder, sieve it and mix it with cellulose and konjac flour, and sieve it to obtain the powder.

[0038] Example 3

[0039] The formula of the composition with weight loss and alcohol sobering effects is shown in Table 3.

[0040] Table 3

[0041]

[0042] The preparation method is as follows:

[0043] (1) Add water to four-leaf ginseng, wolfberry, soybean, hawthorn, and polygonatum to boil and extract (add water equivalent to 5 times the total weight of the above, boil twice, the first decoction is 2 hours, the second decoction is 1.5 hours, the extract is filtered, and the filtrate is combined), and after concentration, a thick paste (specific gravity 1.25-1.35) is obtained;

[0044] (2) Mix the thick paste with cellulose and konjac flour and spray dry them.

[0045] Example 4

[0046] The formula of the composition having weight loss and alcohol sobering effects is shown in Table 4.

[0047] Table 4

[0048]

[0049]

[0050] The preparation method is as follows:

[0051] Grind four-leaf ginseng, wolfberry, soybean, hawthorn and polygonatum into fine powder, sieve it and mix it with cellulose and konjac flour, and sieve it to obtain the powder.

[0052] Example 5

[0053] The preparation method of the tablet having weight loss and alcohol sobering effects is as follows:

[0054] (1) Add 10% starch and 10% dextrin by weight of the composition to the composition prepared in Example 1, sieve and granulate to 80 mesh;

[0055] (2) Pressing into tablets.

[0056] Example 6

[0057] The preparation method of the powder having weight loss and hangover-relieving effects is as follows:

[0058] (1) Add 2% sucrose, 0.05% sweetener, 10% lactose and 1% citric acid by weight of the composition to the composition of Example 3 and mix well to obtain a mixed powder;

[0059] (2) spray drying, sieving, and granulating the mixed powder to obtain a mixture;

[0060] (3) The mixture is packaged into 10 g bags.

[0061] Example 7

[0062] The preparation method of the honey pills with weight loss and hangover relief effects is to add 20% honey by weight to the composition of Example 2 to make honey pills.

[0063] Example 8

[0064] The preparation of the capsules having weight loss and hangover-relieving effects is as follows:

[0065] (1) sieving the composition prepared in Example 1 and granulating the mixture to obtain a mixture A;

[0066] (2) Add 0.05% magnesium stearate by weight of the mixture, mix well, and fill into 0# capsules.

[0067] Example 9

[0068] The preparation of the capsules having weight loss and hangover-relieving effects is as follows:

[0069] (1) sieving the composition prepared in Example 2 and granulating the mixture to obtain a mixture A;

[0070] (2) Add 0.05% magnesium stearate by weight of the mixture, mix well, and fill into 0# capsules.

[0071] Experiment 1: Human Trial - Weight Loss Diet Study

[0072] 16 overweight subjects (BMI index>24) were randomly selected and divided into two groups, Example 1 and Example 2, 8 cases in each group. There was no statistical difference in basic data such as height and weight between the groups. The Example 1 group took the capsules prepared in Example 8, and the Example 2 group took the capsules prepared in Example 9, 3 capsules per day, taken before dinner, with 150 ml of water; after taking for 1 month, a total of 15 cases completed the experiment, 7 cases in the Example 1 group, and 8 cases in the Example 2 group. The comparison of weight and BMI before and after consumption was statistically analyzed, and the results are shown in Tables 5-6 below:

[0073] Table 5

[0074] Group Weight before taking / kg Body weight after taking / kg Weight loss after taking the medicine / kg Example 1 69.78±6.80 66.70±6.70 3.09±1.14 Example 2 71.34±6.18 68.82±6.44 2.48±1.22

[0075] Table 6

[0076]

[0077] The results of the best embodiment 1 are shown in Table 7 below.

[0078] Table 7

[0079]

[0080] Experiment 2: Human Pharmacokinetic Test - Study on the Anti-alcohol Effect

[0081] A single-center, randomized, open-label, two-period, two-sequence crossover pharmacokinetic comparative study was conducted on 12 male volunteers under postprandial conditions with a washout period of 7 days.

[0082] Twelve male subjects underwent a series of examinations, including: demographic data, disease and medication history, physical examination, height and weight, vital signs measurement (pulse, sitting blood pressure, forehead temperature), 12-lead electrocardiogram, alcohol breath test, laboratory tests (blood biochemistry, blood routine, urine routine, four coagulation tests, eight qualitative tests before blood transfusion), and were admitted to a hospital in Nanjing in the first cycle after passing the examination.

[0083] In the first cycle of the experiment, the first subject C001 ate a standard breakfast in a random order, was given medication at 07:30, and took 3 capsules prepared in Example 9 of the present invention, and drank 50 mL of liquor at 08:00, with a time interval of 1 minute between every two subjects. After drinking, blood samples were collected at all pharmacokinetic blood sampling points.

[0084] Then, 7 days after the above-mentioned administration and drinking, 12 male subjects, starting with the first subject C001, drank 50 mL of liquor at 08:00, with a time interval of 1 minute between each two subjects. After the drinking was completed, blood samples were collected at all pharmacokinetic blood collection points.

[0085] All 12 subjects successfully completed two cycles of medication, drinking, and blood sampling at all pharmacokinetic blood sampling points. During the trial, the subjects had good compliance with medication, blood sampling, diet, and daily routine.

[0086] All subjects were hospitalized in a hospital in Nanjing during the observation period, and their diet and daily routine were uniformly managed by the hospital.

[0087] All the biological blood samples in the test tubes were transported to the biological sample testing unit to test the ethanol content in the blood. The pharmacokinetic calculation results of alcohol in the test group and the self-control group were compared in Table 8.

[0088] Table 8 Ethanol content

[0089] Pharmacokinetic parameters Drinking + taking medicine Drink only Cmax(ng / ml) 115.643±42.537 152.572±60.212 AUC0-t (h*ng / ml) 226.748±154.258 272.39±144.214 AUC0-∞(h*ng / ml) 230.846±140.512 276.15±148.351

[0090] Note: There are significant differences in the three main pharmacokinetic parameters Cmax, AUC0-t, and AUC0-∞ when taking the medicine and not taking the medicine.

[0091] Results: The technical background of the weight loss food composed mainly of cellulose and konjac flour of the present invention mainly involves its unique ingredients and mechanism of action.

[0092] The main ingredient in konjac flour is glucomannan, a dietary fiber. Glucomannan absorbs water and swells in the stomach, which increases satiety and reduces the intake of other foods. In addition, glucomannan absorbs cholesterol and bile acid in the body, further aiding weight loss. Konjac flour is very low in calories and fat, making it an effective weight loss food.

[0093] Cellulose, as a dietary fiber, slows down the passage of food from the stomach to the small intestine, delaying digestion and absorption of nutrients. Nanocellulose combines with dietary fat to interfere with the activity of pancreatic lipase, thereby reducing fat digestion and absorption.

[0094] Adding Chinese medicinal materials such as four-leaf ginseng, wolfberry, soybean, hawthorn, and polygonatum, which are both medicinal and edible, to the above formula can not only supplement the human body with vitamins, trace elements and essential amino acids, but also help with weight loss and hangover relief. It has achieved remarkable technical effects and has good prospects for application and promotion.

[0095] The above detailed description is a specific description of one feasible embodiment of the present invention. The embodiment is not intended to limit the patent scope of the present invention. Any equivalent implementation or modification that does not deviate from the present invention should be included in the scope of the technical solution of the present invention.

Claims

1. A composition having weight loss and hangover sobering effects, characterized in that: The raw materials of the composition include the following components: cellulose, konjac flour, four-leaf ginseng, wolfberry, soybean, hawthorn and polygonatum.

2. The composition according to claim 1, characterized in that The raw materials of the composition include the following components by weight: 35-95 parts of cellulose, 5-55 parts of konjac flour, 1-5 parts of four-leaf ginseng, 2-10 parts of wolfberry, 2-8 parts of soybean, 1-10 parts of hawthorn and 1-5 parts of polygonatum.

3. The composition according to claim 1, characterized in that The raw materials of the composition include the following components by weight: 35-50 parts of cellulose, 30-45 parts of konjac flour, 3-5 parts of four-leaf ginseng, 3-8 parts of wolfberry, 2-6 parts of soybean, 3-7 parts of hawthorn and 1-4 parts of polygonatum.

4. A method for preparing the composition according to any one of claims 1 to 3, characterized in that: The method comprises grinding four-leaf ginseng, wolfberry, soybean, hawthorn and polygonatum into fine powder, and mixing the powder with cellulose and konjac flour.

5. A method for preparing the composition according to any one of claims 1 to 3, characterized in that: The steps include: (1) Mix four-leaf ginseng, wolfberry, soybean, hawthorn and polygonatum, add solvent for extraction, and concentrate the extract to obtain a thick paste; (2) Mix the thick paste with cellulose and konjac flour.

6. The preparation method according to claim 5, characterized in that: In step (1), the solvent is water, and the extraction is decoction.

7. The preparation method according to claim 5, characterized in that: The solvent in step (1) is an ethanol aqueous solution with a volume concentration of 55-75%, and the extraction is a heating reflux extraction.

8. The preparation method according to claim 5, characterized in that: The extraction times in step (1) are 1-3 times, the time of each extraction is 0.5-2 hours, and the solvent is 5-10 times the total mass of four-leaf ginseng, wolfberry, soybean, hawthorn and polygonatum.

9. A pharmaceutical preparation, characterized in that The raw materials of the pharmaceutical preparation include the composition according to any one of claims 1 to 3 or the composition obtained by the preparation method according to any one of claims 4 to 8, and pharmaceutically acceptable excipients. The dosage form of the pharmaceutical preparation is capsule, tablet, granule or gel.

10. Use of the composition according to any one of claims 1 to 3 or the composition obtained by the preparation method according to any one of claims 4 to 8 in preparing a product having weight loss and alcohol sobering effects.

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