Pancreatic cancer electric field therapeutic instrument electrode patch pasting vest and electrode patch diaphragm material

Abstract

The invention discloses a pancreatic cancer electric field therapeutic instrument electrode patch pasting vest and an electrode patch diaphragm material, and belongs to the field of medical instruments, the pancreatic cancer electric field therapeutic instrument electrode patch pasting vest comprises a vest main body, and the vest main body is made of a soft and breathable medical non-woven fabric material with certain elasticity; a plurality of miniature negative pressure chambers are arranged on the inner side, corresponding to the pancreas part of a human body, of the vest main body, and the miniature negative pressure chambers are connected with an external negative pressure source through fine and soft silicone tubes with good sealing performance; the micro negative pressure chamber is provided with an electrode patch, the electrode patch comprises a nitrocellulose film and a conductive metal organic framework material, the conductive metal organic framework material is modified on a flexible and breathable nitrocellulose film substrate, transduction of a transcutaneous electrical stimulation signal can be ensured, and the transdermal electrical stimulation effect is improved. Good water vapor permeability is provided, and good adhesion with sweating skin can be realized.

Description

Technical Field

[0001] The invention relates to the technical field of medical devices, and in particular to an electrode patch application vest for an electric field therapeutic device for pancreatic cancer and an electrode patch diaphragm material. Background Art

[0002] Pancreatic cancer is a highly malignant tumor, and traditional treatment methods have limited effects. Electric field therapy has gradually attracted attention as an emerging treatment method, but the existing electrode patches and supporting devices have deficiencies in terms of application stability, sweat protection, and compatibility with human skin. Long-term sweat accumulation can easily have a negative impact on the signal of transcutaneous electrical stimulation. In addition, it is easy to cause allergic reactions. The existing transcutaneous electrical stimulation electrode design is not conducive to long-term adhesion, and it is difficult to meet the precise, continuous, and comfortable treatment needs during the treatment of pancreatic cancer.

[0003] Therefore, there is a need for an electrode patch application vest and an electrode patch diaphragm material for a pancreatic cancer electric field therapy device. Summary of the invention

[0004] In view of the deficiencies in the prior art, the present invention provides an electrode patch application vest for an electric field therapy device for pancreatic cancer and an electrode patch diaphragm material, which solves the problems raised in the above-mentioned background technology.

[0005] Technical solution: To solve the above technical problems, according to one aspect of the present invention, more specifically, a pancreatic cancer electric field therapy device electrode patch application vest includes a vest body, the vest body is made of a soft, breathable and elastic medical non-woven fabric; the inner side of the vest body corresponding to the pancreatic part of the human body is provided with a plurality of micro negative pressure chambers, the micro negative pressure chambers are connected to an external negative pressure source through a thin, soft and well-sealed silicone tube; the micro negative pressure chambers are provided with electrode patches.

[0006] Furthermore, the electrode patch includes a nitrocellulose film and a conductive metal organic framework material, and the preparation method of the electrode patch is as follows;

[0007] S1. Take 50 mg of Cu3HHTP2 powder and dissolve it in 5 mL of 0.1 M phosphate buffered saline solution. The pH value of the phosphate buffered saline solution is precisely controlled at 7.4 (to simulate the physiological environment of the human body and enhance the biocompatibility of the electrode patch). Continue ultrasonic treatment for 6 hours (ultrasonic power between 100-200 W) to evenly disperse the Cu3HHTP2 powder. During this period, stir the solution every 1 hour to prevent powder precipitation and ensure the formation of a stable Cu3HHTP2 dispersion. The stirring speed is controlled at 200-300 rpm to promote the uniform distribution of Cu3HHTP2 powder in the solution, avoid agglomeration, and form a stable Cu3HHTP2 dispersion;

[0008] S2. Carefully transfer the patterned nitrocellulose membrane to the Cu3HHTP2 dispersion and perform ultrasonic treatment again for 6 hours to ensure that the nitrocellulose membrane fully absorbs the Cu3HHTP2 material and achieves a close combination of the two, thus giving the electrode patch good conductivity and biocompatibility.

[0009] S3. After the ultrasonic treatment, gently take out the nitrocellulose membrane electrode adsorbed with Cu3HHTP2 and place it in a clean, dry and well-ventilated environment to dry naturally. The relative humidity should be controlled at 30%-40%, and the temperature should be maintained at around 25°C. An air purification device should be set up to prevent dust and impurities from contaminating the electrode patch. The drying time is 24 hours. Finally, a transcutaneous electrical stimulation electrode patch based on a metal organic framework is obtained. The patch has precise electrical stimulation performance, good bioadaptability and stable physical properties. In the subsequent electric field therapy process, it can stably transmit electrical signals, and at the same time has a good fit with human skin and will not cause allergies or other adverse reactions.

[0010] Furthermore, the preparation method of the conductive metal organic framework material Cu3HHTP2 is as follows:

[0011] S1. Accurately weigh 6.4 mg of copper acetate and 5.2 mg of HHTP, dissolve them together in a sealed glass bottle containing 4.5 mL of methanol to form a mixed solution; first ultrasonically treat the mixture for 30 minutes, using an ultrasonic cleaner with a frequency of 30 kHz and a power of 80-120 W to promote the full dissolution and preliminary reaction of the raw materials, and then place it in a 65-degree water bath for continuous heating for 24 hours, using a water bath with temperature control and stirring functions, and controlling the stirring speed at 100-150 rpm to ensure that the reaction is uniform and complete. At the same time, a reflux condenser is set above the water bath to prevent methanol from volatilizing and ensure the volume stability of the reaction system;

[0012] S2. After the reaction is completed, the product is washed several times with sufficient deionized water and acetone, the amount of deionized water and acetone used is 10-20 times the volume of the product, respectively, to ensure that the impurities are completely removed; the product is then collected by centrifugation, the centrifugal speed is 5000-8000 rpm, the centrifugal time is 10-15 minutes, the product is collected by centrifugation, and the obtained Cu3HHTP2 powder is heated at 80°C for 24 hours to completely remove excess solvent. During the heating process, the product is stirred every 4-6 hours to ensure that the solvent is fully volatilized, and a high-purity, stable-performance Cu3HHTP2 powder is obtained, which provides excellent conductive properties for the electrode patch (4).

[0013] According to another aspect of the present invention, more specifically, the electrode patch diaphragm material used in any of the above pancreatic cancer electric field therapy device electrode patch vests includes a nitrocellulose film, and the preparation method is as follows:

[0014] S1. Accurately weigh 10 g of bacterial nanocellulose gel, evenly disperse it in 150 mL of deionized water, and use ultrasonic treatment for 5 minutes at an ultrasonic frequency of 35 kHz and a power of 150 W to ensure that a uniform and stable bacterial nanocellulose dispersion is obtained;

[0015] S2. Carefully pour the bacterial nanocellulose dispersion onto the support membrane, and then use a suction pump to perform vacuum filtration in conjunction with a polyvinylidene fluoride filter membrane; the vacuum degree of the suction pump is set between -0.08 and 0.1 MPa, and the film thickness is precisely controlled by precisely adjusting the vacuum filtration time, and finally a nitrocellulose membrane with a thickness of about 10-20 microns is prepared;

[0016] During the vacuum filtration process, a laser rangefinder is used to monitor the thickness of the film in real time. According to the thickness measurement results, the vacuum degree of the suction pump and the filtration time are adjusted to ensure the uniformity and accuracy of the film thickness. This thickness range can not only ensure the mechanical strength of the diaphragm, but also meet the good electrical conductivity adaptability, so that it can withstand certain mechanical stress in the subsequent use process, and at the same time does not hinder the transmission of electrical signals;

[0017] S3. After vacuum filtration is completed, the filter paper carrying the nitrocellulose membrane is transferred to a 65-degree oven for drying to solidify the film. After drying, the nitrocellulose membrane is gently and completely peeled off from the filter membrane, and patterned cutting is performed using high-precision cutting equipment according to the pre-designed electrode shape to meet the subsequent assembly requirements of the electrode patch (4).

[0018] The beneficial effects of the electrode patch vest and the electrode patch diaphragm material of the pancreatic cancer electric field therapeutic device of the present invention are:

[0019] (1) The nitrocellulose membrane in the present invention is composed of interconnected porous nanocellulose, and its surface has sufficient carboxyl groups and strong hydrogen bonding, which is conducive to surface modification. Nitrocellulose membrane is a flexible material with excellent mechanical strength and high ductility, and can fit well on the skin surface. The structure of the nitrocellulose film has a large number of micron-sized pores randomly distributed in the cellulose network. The conductive metal organic framework has a unique porous structure and is conductive. Modifying the conductive metal organic framework material on the flexible and breathable nitrocellulose membrane substrate can provide good water vapor permeability while ensuring the conduction of transcutaneous electrical stimulation signals, and can adhere well to sweating skin. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The present invention is further described in detail below with reference to the accompanying drawings and specific implementation methods.

[0021] Figure 1 It is a schematic diagram of the structure of the present invention.

[0022] In the figure: 1. Vest body; 2. Micro negative pressure chamber; 3. Silicone tube; 4. Electrode patch. DETAILED DESCRIPTION

[0023] The present invention will be described in detail below with reference to the accompanying drawings and in combination with embodiments. It should be noted that the embodiments and features in the embodiments of the present application can be combined with each other without conflict.

[0024] In order to make the technical solution of the present invention clearer, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0025] According to one aspect of the present invention, more specifically, a pancreatic cancer electric field therapeutic device electrode patch is applied to a vest, such as Figure 1 As shown, it includes a vest body 1, which is made of a soft, breathable and elastic medical non-woven fabric to ensure that the patient is comfortable wearing and does not interfere with daily activities; a plurality of micro negative pressure chambers 2 are arranged on the inner side of the vest body 1 corresponding to the pancreatic part of the human body, and the micro negative pressure chamber 2 is connected to the external negative pressure source through a small, soft and well-sealed silicone tube 3; an electrode patch 4 is arranged inside the micro negative pressure chamber 2; when the electrode patch 4 is applied to the skin, the negative pressure source is started to form a uniform and stable negative pressure environment in the chamber, so that the electrode patch 4 can be tightly and flatly attached to the surface of the human skin, effectively avoiding the problem of patch displacement and shedding caused by human activities, sweating and other factors, and ensuring the continuous and accurate electric field therapy.

[0026] Preferably, the electrode patch 4 includes a nitrocellulose film and a conductive metal organic framework material, and the preparation method of the electrode patch 4 is as follows:

[0027] The electrode patch (4) comprises a nitrocellulose film and a conductive metal organic framework material. The preparation method of the electrode patch (4) is as follows;

[0028] S1. Take 50 mg of Cu3HHTP2 powder and dissolve it in 5 mL of 0.1 M phosphate buffered saline solution. The pH value of the phosphate buffered saline solution is precisely controlled at 7.4 (to simulate the physiological environment of the human body and enhance the biocompatibility of the electrode patch). Continue ultrasonic treatment for 6 hours (ultrasonic power between 100-200 W) to evenly disperse the Cu3HHTP2 powder. During this period, stir the solution every 1 hour to prevent powder precipitation and ensure the formation of a stable Cu3HHTP2 dispersion. The stirring speed is controlled at 200-300 rpm to promote the uniform distribution of Cu3HHTP2 powder in the solution, avoid agglomeration, and form a stable Cu3HHTP2 dispersion;

[0029] S2. Carefully transfer the patterned nitrocellulose membrane to the Cu3HHTP2 dispersion and perform ultrasonic treatment again for 6 hours to ensure that the nitrocellulose membrane fully absorbs the Cu3HHTP2 material and achieves a close combination of the two, thus giving the electrode patch good conductivity and biocompatibility.

[0030] S3. After the ultrasonic treatment, gently take out the nitrocellulose membrane electrode adsorbed with Cu3HHTP2 and place it in a clean, dry and well-ventilated environment to dry naturally. The relative humidity should be controlled at 30%-40%, and the temperature should be maintained at around 25°C. An air purification device should be set up to prevent dust and impurities from contaminating the electrode patch. The drying time is 24 hours. Finally, a transcutaneous electrical stimulation electrode patch based on a metal organic framework is obtained. The patch has precise electrical stimulation performance, good bioadaptability and stable physical properties. In the subsequent electric field therapy process, it can stably transmit electrical signals, and at the same time has a good fit with human skin and will not cause allergies or other adverse reactions.

[0031] Preferably, the preparation method of the conductive metal organic framework material Cu3HHTP2 is as follows:

[0032] Using Cu as the central atom, a specific organic ligand 2,3,6,7,10,11-hexahydroxytriphenylenehydrate (CAS No.: 4877-80-9, English name: 2,3,6,7,10,11-Hexahydroxytriphenylenehydrate, HHTP) was selected to synthesize the conductive metal organic framework material Cu3HHTP2;

[0033] S1. Accurately weigh 6.4 mg of copper acetate and 5.2 mg of HHTP, dissolve them together in a sealed glass bottle containing 4.5 mL of methanol to form a mixed solution; first ultrasonically treat the mixture for 30 minutes, using an ultrasonic cleaner with a frequency of 30 kHz and a power of 80-120 W to promote the full dissolution and preliminary reaction of the raw materials, and then place it in a 65-degree water bath for continuous heating for 24 hours, using a water bath with temperature control and stirring functions, and controlling the stirring speed at 100-150 rpm to ensure that the reaction is uniform and complete. At the same time, a reflux condenser is set above the water bath to prevent methanol from volatilizing and ensure the volume stability of the reaction system;

[0034] S2. After the reaction is completed, the product is washed several times with sufficient deionized water and acetone, the amount of deionized water and acetone used is 10-20 times the volume of the product, respectively, to ensure that the impurities are completely removed; the product is then collected by centrifugation, the centrifugal speed is 5000-8000 rpm, the centrifugal time is 10-15 minutes, the product is collected by centrifugation, and the obtained Cu3HHTP2 powder is heated at 80°C for 24 hours to completely remove excess solvent. During the heating process, the product is stirred every 4-6 hours to ensure that the solvent is fully volatilized, and a high-purity, stable-performance Cu3HHTP2 powder is obtained, which provides excellent conductive properties for the electrode patch 4.

[0035] According to another aspect of the present invention, more specifically, the electrode patch diaphragm material includes a nitrocellulose film, and the preparation method comprises the following steps:

[0036] S1. Accurately weigh 10 g of bacterial nanocellulose gel, evenly disperse it in 150 mL of deionized water, and use ultrasonic treatment for 5 minutes at an ultrasonic frequency of 35 kHz and a power of 150 W to ensure that a uniform and stable bacterial nanocellulose dispersion is obtained;

[0037] S2. Carefully pour the bacterial nanocellulose dispersion onto the support membrane, and then use a suction pump to perform vacuum filtration in conjunction with a polyvinylidene fluoride filter membrane; the vacuum degree of the suction pump is set between -0.08 and 0.1 MPa, and the film thickness is precisely controlled by precisely adjusting the vacuum filtration time (30-60 minutes), and finally a nitrocellulose membrane with a thickness of about 10-20 microns is prepared;

[0038] During the vacuum filtration process, a laser rangefinder is used to monitor the thickness of the film in real time. According to the thickness measurement results, the vacuum degree of the suction pump and the filtration time are adjusted to ensure the uniformity and accuracy of the film thickness. This thickness range can not only ensure the mechanical strength of the diaphragm, but also meet the good electrical conductivity adaptability, so that it can withstand certain mechanical stress in the subsequent use process, and at the same time does not hinder the transmission of electrical signals;

[0039] S3. After completing the vacuum filtration, the filter paper carrying the nitrocellulose membrane is transferred to a 65-degree oven for drying to solidify the film. After drying, the nitrocellulose membrane is gently and completely peeled off from the filter membrane, and patterned cut using high-precision cutting equipment according to the pre-designed electrode shape to meet the subsequent assembly requirements of the electrode patch 4.

[0040] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A vest for applying an electrode patch of an electric field therapy device for pancreatic cancer, comprising a vest body (1), characterized in that: The vest body (1) is made of a medical non-woven fabric that is soft, breathable and has a certain elasticity; a plurality of micro negative pressure chambers (2) are arranged on the inner side of the vest body (1) corresponding to the pancreas of the human body, and the micro negative pressure chambers (2) are connected to an external negative pressure source via a silicone tube (3); and an electrode patch (4) is arranged inside the micro negative pressure chamber (2).

2. The electrode patch application vest of the pancreatic cancer electric field therapy device according to claim 1, characterized in that: The electrode patch (4) comprises a nitrocellulose film and a conductive metal organic framework material. The preparation method of the electrode patch (4) is as follows; S1. Take 50 mg of Cu3HHTP2 powder, dissolve it in 5 mL of 0.1 M phosphate buffered saline solution, and continue ultrasonic treatment for 6 hours to make the Cu3HHTP2 powder evenly dispersed; S2. Carefully transfer the patterned nitrocellulose membrane to the Cu3HHTP2 dispersion and perform ultrasonic treatment again for 6 hours to ensure that the nitrocellulose membrane fully absorbs the Cu3HHTP2 material and achieves a close combination of the two, thus giving the electrode patch good conductivity and biocompatibility. S3. After the ultrasonic treatment, the nitrocellulose membrane electrode adsorbed with Cu3HHTP2 is gently taken out and placed in a clean, dry and well-ventilated environment to dry naturally. The relative humidity should be controlled at 30%-40%, and the temperature should be maintained at about 25°C. An air purification device is set to prevent dust and impurities from contaminating the electrode patch. The drying time is 24 hours. Finally, a transcutaneous electrical stimulation electrode patch based on a metal organic framework is obtained. The electrode patch (4) has precise electrical stimulation performance, good bioadaptability and stable physical properties. In the subsequent electric field treatment process, it can stably transmit electrical signals and has a good fit with human skin without causing allergies or other adverse reactions.

3. The electrode patch vest for pancreatic cancer electric field therapy device according to claim 2, characterized in that: The preparation method of the conductive metal organic framework material Cu3HHTP2 is as follows: S1. Accurately weigh 6.4 mg of copper acetate and 5.2 mg of HHTP, and dissolve them together in a sealed glass bottle containing 4.5 mL of methanol to form a mixed solution; firstly subject the mixture to ultrasonic treatment for 30 minutes, using an ultrasonic cleaner with a frequency of 30 kHz and a power of 80-120 W to ultrasonic treatment to promote the full dissolution and preliminary reaction of the raw materials, and then place it in a water bath at 65 degrees and continue heating for 24 hours, using a water bath with temperature control and stirring function, and controlling the stirring speed at 100-150 rpm to ensure that the reaction is uniform and complete; at the same time, a reflux condenser is set above the water bath to prevent methanol from volatilizing and ensure the volume stability of the reaction system; S2. After the reaction is completed, the product is washed several times with sufficient deionized water and acetone. The amount of deionized water and acetone used is 10-20 times the volume of the product, respectively, to ensure that the impurities are completely removed. The product is then collected by centrifugation at a speed of 5000-8000 rpm for 10-15 minutes. The product is collected by centrifugation, and the obtained Cu3HHTP2 powder is heated to completely remove excess solvent to obtain high-purity, stable-performance Cu3HHTP2 powder, which provides excellent conductive properties for the electrode patch (4).

4. The electrode patch vest for pancreatic cancer electric field therapy device according to claim 2, characterized in that: The pH value of the phosphate buffered saline solution is precisely controlled at 7.4, and is used to simulate the physiological environment of the human body and enhance the biocompatibility of the electrode patch.

5. The electrode patch vest for pancreatic cancer electric field therapy device according to claim 2, characterized in that: When Cu3HHTP2 powder is dissolved in phosphate buffered saline solution and ultrasonically treated, the solution is stirred once every 1 hour to prevent powder precipitation and ensure the formation of a stable Cu3HHTP2 dispersion; the stirring speed is controlled at 200-300 rpm to promote the uniform distribution of Cu3HHTP2 powder in the solution, avoid agglomeration, and form a stable Cu3HHTP2 dispersion.

6. The electrode patch vest for pancreatic cancer electric field therapy device according to claim 3, characterized in that: The Cu3HHTP2 powder collected by the centrifugal operation is heated at 80°C for 24 hours to completely remove excess solvent. During the heating process, the product is stirred every 4-6 hours to ensure that the solvent is fully volatilized to obtain a high-purity, stable-performance Cu3HHTP2 powder.

7. The electrode patch diaphragm material used in the electrode patch vest of the pancreatic cancer electric field therapy device according to any one of claims 1 to 6 comprises a nitrocellulose film, characterized in that: The preparation method comprises the following steps: S1. Accurately weigh 10 g of bacterial nanocellulose gel, evenly disperse it in 150 mL of deionized water, and use ultrasonic treatment for 5 minutes to obtain a bacterial nanocellulose dispersion; S2, carefully pouring the bacterial nanocellulose dispersion onto the scaffold membrane, and then using a suction pump, vacuum filtration was performed with a polyvinylidene fluoride filter membrane; a nitrocellulose membrane with a thickness of about 10-20 microns was prepared; During the vacuum filtration process, a laser rangefinder is used to monitor the thickness of the film in real time. According to the thickness measurement results, the vacuum degree of the suction pump and the filtration time are adjusted to ensure the uniformity and accuracy of the film thickness. This thickness range can not only ensure the mechanical strength of the diaphragm, but also meet the good electrical conductivity adaptability, so that it can withstand certain mechanical stress in the subsequent use process, and at the same time does not hinder the transmission of electrical signals; S3. After vacuum filtration is completed, the filter paper carrying the nitrocellulose membrane is transferred to a 65-degree oven for drying to solidify the film. After drying, the nitrocellulose membrane is gently and completely peeled off from the filter membrane, and patterned cutting is performed using high-precision cutting equipment according to the pre-designed electrode shape to meet the subsequent assembly requirements of the electrode patch (4).

8. The electrode patch diaphragm material according to claim 7, characterized in that: The vacuum degree of the suction pump is set between -0.08 and 0.1 MPa, and precise control of the film thickness is achieved by precisely adjusting the vacuum filtration time.

9. The electrode patch diaphragm material according to claim 7, characterized in that: The ultrasonic frequency in the ultrasonic treatment is 35 kHz and the power is 150 W, so as to ensure a uniform and stable bacterial nanocellulose dispersion.

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