Concentrated solution for stabilizing non-polar organic matter and water by using fumed silica as well as preparation method and application of concentrated solution

Abstract

The invention belongs to the technical field of silicon dioxide, and relates to a concentrated solution for stabilizing non-polar organic matters and water by using fumed silica as well as a preparation method and application of the concentrated solution. According to the preparation method disclosed by the invention, mixing is carried out in nano-scale gaps of hydrophilic hydrated fumed silica, hydrophobic hydrated fumed silica or a mixture of the hydrophilic hydrated fumed silica and the hydrophobic hydrated fumed silica, so that water and non-polar organic matters can form a stable suspension within a very wide temperature and concentration range, and the intersolubility is remarkably improved. Due to the high specific surface area and the porous structure of the hydrated fumed silica, the hydrated fumed silica can be simultaneously wetted by water and non-polar organic matters to form a uniform mixture without obvious organic phase and water phase interfaces, so that a concentrated solution can be kept stable for a long time in different media and cannot be layered.

Description

Technical Field

[0001] The invention belongs to the technical field of silicon dioxide, and relates to a concentrated solution of non-polar organic matter and water stabilized by using gas phase silicon dioxide, and a preparation method and application thereof. Background Art

[0002] Known methods for preparing concentrated mixtures of water and non-polar organic matter generally include using surfactants and stabilizers, and converting water particles or oil particles into micron droplets through ultrasonic treatment so that they are evenly distributed in the dispersion medium. This method is widely used in many industrial and laboratory applications because it can effectively improve the mixing uniformity of water and non-polar organic matter. However, this method has some significant limitations, especially in terms of miscibility. Water and non-polar organic matter are essentially immiscible, which leads to easy stratification during the mixing process, affecting the stability and performance of the final product.

[0003] Specifically, water and non-polar organics have poor miscibility due to differences in their chemical properties and intermolecular forces. Water is a polar solvent with a strong hydrogen bond network, while non-polar organics lack this polarity, making it difficult for them to form a stable mixture. At lower temperatures, this miscibility problem becomes more prominent. As the temperature decreases, the miscibility of water and non-polar organics decreases further, or even becomes completely insoluble. This is because lowering the temperature causes the molecular motion to slow down and the intermolecular forces to increase, making it more difficult for the two substances to mix together.

[0004] In addition, although the use of surfactants and stabilizers can improve the miscibility of water and non-polar organic matter to a certain extent, these additives themselves may also bring some side effects. For example, surfactants may form a stable interfacial film in the mixture, hindering further contact and mixing of water and non-polar organic matter. Stabilizers may affect the physical and chemical properties of the final product, such as viscosity, transparency and stability. These problems may become particularly serious in certain applications, especially in the fields of cosmetics, medical materials and extractants that require high stability and high performance.

[0005] Chinese patent application document (CN116143130A) discloses a water-dispersible sol of hydrophobic fumed silica and a method for preparing the same. The disadvantage of the above invention is that surfactants are required, which together with hydrophobic silica particles form an ordered molecular system in which the surfactant molecules are arranged in such a way that the hydrophobic end is connected to the hydrophobic silica particles and the polar end is immersed in water (dissolved). In this case, to form a hydrophobic particle system in water, it must be separated by external molecules, which is undesirable for medical and biotechnology composite materials. Summary of the invention

[0006] The purpose of the present invention is to solve the above problems in the prior art and to provide a concentrated solution of non-polar organic matter and water stabilized by fumed silica, which has low cost, strong mutual solubility and stable performance.

[0007] The purpose of the present invention can be achieved by the following technical solutions:

[0008] A concentrated solution of non-polar organic matter and water is stabilized by using fumed silica. The paste suspension comprises the following raw materials in parts by mass: 3-120 parts of non-polar hydrocarbons, 3-120 parts of water, and 30-150 parts of hydrated fumed silica.

[0009] In the above-mentioned concentrated solution of non-polar organic matter and water stabilized by fumed silica, the concentrated solution comprises the following raw materials in parts by mass: 55-65 parts of non-polar hydrocarbons, 30-50 parts of water, and 80-120 parts of hydrated fumed silica.

[0010] In the above-mentioned concentrated solution of non-polar organic matter and water stabilized by using fumed silica, the non-polar organic matter includes at least one of decane and deuterated chloroform.

[0011] In the above-mentioned concentrated solution of non-polar organic matter and water stabilized by using fumed silica, the particle size of silica particles is 0.5-50 μm.

[0012] In the above-mentioned concentrated solution of non-polar organic matter and water stabilized by using fumed silica, the silica includes at least one of hydrophilic hydrated fumed silica and hydrophobic hydrated fumed silica.

[0013] In the present invention, liquid hydrocarbons are not mixed with liquid water to form a two-phase system. In the binary mixture, chloroform is located at the bottom of the container due to its high density, and decane is located at the top of the container (ρ=0.73g / cm3). Within the temperature variation range of 293K, the mutual solubility of water-chloroform or water-decane does not exceed 1wt%. As the temperature decreases, the solubility will decrease, or even lower. In order to increase the mutual solubility of water and non-polar substances, the present invention mixes them in the presence of hydrophilic or hydrophobic silica or its mixture: for hydrophilic silica, non-polar hydrocarbons are added to the dry powder, and then water is added during stirring. For hydrophobic silica or its mixture with hydrophilic silica, non-polar hydrocarbons are added under stirring, and then water is added under mechanical load. Mechanical load can provide pressure by grinding in a porcelain mortar or an extruder, and the silica surface can stabilize the organic water mixture over a wide temperature and concentration range. If these feed ratios are exceeded, the suspension may separate into an aqueous phase and an organic phase, each containing suspended silica or separate hydrocarbons and water.

[0014] In the above-mentioned concentrated solution of non-polar organic matter and water stabilized by using fumed silica, the silica is a hydrophilic hydrated fumed silica and a hydrophobic hydrated fumed silica in a mass ratio of (1-5):(5-1).

[0015] Preferably, the hydrophilic hydrated fumed silica is silica A-300.

[0016] Preferably, the hydrophobic hydrated fumed silica is silica AM-1-200.

[0017] The present invention also provides a method for preparing the concentrated solution of non-polar organic matter and water stabilized by using fumed silica, the method comprising the following steps:

[0018] S1. Prepare raw materials;

[0019] S2, treating the hydrated fumed silica by a wetting-drying method;

[0020] S3. The hydrated fumed silica and the non-polar hydrocarbon are then mechanically mixed and water is added to obtain a concentrated solution.

[0021] In the above-mentioned method for preparing a concentrated solution of non-polar organic matter and water by using fumed silica, the volume density C of the silica particles after the wet-drying method treatment is d =210-250mg / cm 3 , residual moisture content C H2O ≤50mg / g.

[0022] In the above-mentioned method for preparing a concentrated solution of non-polar organic matter and water by using fumed silica to stabilize the solution, the mechanical mixing includes one of mechanical stirring and ultrasonic treatment.

[0023] The present invention also provides an application of the concentrated solution or the concentrated solution prepared by the preparation method in cosmetics, medical materials and extractants.

[0024] Preferably, a method for preparing a cosmetic or medical material or an extractant comprises adding an organic acid to the above-mentioned paste suspension.

[0025] Still more preferably, the organic acid is trifluoroacetic acid.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] 1. The present invention allows water and non-polar organic matter to form a stable suspension in a wide range of temperature and concentration by mixing hydrophilic hydrated fumed silica, hydrophobic hydrated fumed silica or a mixture thereof in nanometer-scale gaps, thereby significantly improving mutual solubility.

[0028] 2. The high specific surface area and porous structure of the hydrated fumed silica of the present invention enable it to be wetted by water and non-polar organic matter at the same time to form a uniform mixture without obvious organic and aqueous phase interfaces, which enables the concentrated solution to remain stable for a long time in different media without stratification.

[0029] 3. The concentrated solution prepared by the method of the present invention can dissolve not only polar substances but also non-polar substances, and is suitable for preparing various complex systems such as cosmetics, medical materials and extractants. This concentrated solution performs better in different application fields and has a wider applicability. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 The water in the hydrated silicon dioxide powder in the air medium (a), the dechloromethane medium (b) and the trifluoroacetic acid added tritiated chloroform (CDCl3) medium (c) 1 Temperature dependence of H NMR spectra.

[0031] Figure 2 The temperature relationship curves of the non-freezing water concentration of hydrated silica in different media, the relationship curve of the Gibbs free energy change to the non-freezing water concentration based on this (a), and the radius distribution of the adsorbed water clusters (b).

[0032] Figure 3 The water in the suspension prepared based on methyl silica AM-1 (a) in Example 2 and the A-300 / AM1 mixture (b) in Example 3 at different temperatures 1 H NMR spectroscopy.

[0033] Figure 4 The results are given in Table 1 for the suspensions of water and n-decane in hydrophilic and hydrophobic silica mixtures at different temperatures. 1 H NMR spectra, a. n-decane was added at 1 g / g; b. n-decane was added at 0.5 g / g; c. n-decane was added at 1.4 g / g. DETAILED DESCRIPTION

[0034] The following are specific embodiments of the present invention, which further describe the technical solutions of the present invention, but the present invention is not limited to these embodiments.

[0035] Embodiment 1:

[0036] S1. The hydrophilic hydrated fumed silica is treated by a wet-drying method to obtain a packing density of 230 mg / cm 3 , residual moisture does not exceed 50mg / g;

[0037] The hydrophilic hydrated fumed silica is fumed silica A-300 purchased from Wacker;

[0038] S2. Prepare the following raw materials in parts by weight: 60 parts of deuterated chloroform, 40 parts of water, and 100 parts of hydrated fumed silica treated by a wet-drying method;

[0039] S3. Mechanically stirring deuterated chloroform and hydrated fumed silica, and then adding water under mechanical stirring to obtain a concentrated solution.

[0040] Embodiment 2:

[0041] S1. The hydrophobic hydrated fumed silica is treated by a wet-drying method to obtain a packing density of 210 mg / cm 3 , residual moisture does not exceed 50mg / g;

[0042] The hydrophobic hydrated fumed silica was AM-1 (methyl silica) purchased from Wacker;

[0043] S2, prepare the following raw materials in parts by weight: 60 parts of deuterated chloroform, 40 parts of water, and 100 parts of hydrated fumed silica treated by a wet-drying method;

[0044] S3. Mechanically stirring deuterated chloroform and hydrated fumed silica, and then adding water under mechanical stirring to obtain a concentrated solution.

[0045] Embodiment 3:

[0046] S1. The hydrophobic and hydrophilic hydrated fumed silica were treated by a wet-drying method to obtain a packing density of 250 mg / cm 3 , residual moisture does not exceed 50mg / g;

[0047] The hydrophobic hydrated fumed silica was AM-1 (methyl silica) purchased from Wacker;

[0048] The hydrophilic hydrated fumed silica was fumed silica A-300 purchased from Wacker;

[0049] S2, prepare the following raw materials in parts by weight: 60 parts of deuterated chloroform, 40 parts of water, 50 parts of hydrophobic hydrated fumed silica treated by a wet-drying method, and 50 parts of hydrophilic hydrated fumed silica treated by a wet-drying method;

[0050] S3. Mechanically stirring deuterated chloroform and hydrated fumed silica, and then adding water under mechanical stirring to obtain a concentrated solution.

[0051] Embodiment 4:

[0052] S1. The hydrophobic and hydrophilic hydrated fumed silica were treated by a wet-drying method to obtain a packing density of 250 mg / cm 3 , residual moisture does not exceed 50mg / g;

[0053] The hydrophobic hydrated fumed silica was AM-1 (methyl silica) purchased from Wacker;

[0054] The hydrophilic hydrated fumed silica was fumed silica A-300 purchased from Wacker;

[0055] S2, prepare the following raw materials in parts by weight: 60 parts of n-decane, 40 parts of water, 40 parts of hydrophobic hydrated fumed silica treated by a wet-drying method, and 60 parts of hydrophilic hydrated fumed silica treated by a wet-drying method;

[0056] S3. Mechanically stirring deuterated chloroform and hydrated fumed silica, and then adding water under mechanical stirring to obtain a concentrated solution.

[0057] Embodiment 5:

[0058] S1. The hydrophobic and hydrophilic hydrated fumed silica were treated by a wet-drying method to obtain a packing density of 250 mg / cm 3 , residual moisture does not exceed 50mg / g;

[0059] The hydrophobic hydrated fumed silica was AM-1 (methyl silica) purchased from Wacker;

[0060] The hydrophilic hydrated fumed silica was fumed silica A-300 purchased from Wacker;

[0061] S2, prepare the following raw materials in parts by weight: 60 parts of n-decane, 40 parts of water, 25 parts of hydrophobic hydrated fumed silica treated by a wet-drying method, and 75 parts of hydrophilic hydrated fumed silica treated by a wet-drying method;

[0062] S3. Mechanically stirring deuterated chloroform and hydrated fumed silica, and then adding water under mechanical stirring to obtain a concentrated solution.

[0063] Embodiment 6:

[0064] S1. The hydrophobic and hydrophilic hydrated fumed silica were treated by a wet-drying method to obtain a packing density of 250 mg / cm 3 , residual moisture does not exceed 50mg / g;

[0065] The hydrophobic hydrated fumed silica was AM-1 (methyl silica) purchased from Wacker;

[0066] The hydrophilic hydrated fumed silica was fumed silica A-300 purchased from Wacker;

[0067] S2, prepare the following raw materials in parts by weight: 60 parts of n-decane, 40 parts of water, 75 parts of hydrophobic hydrated fumed silica treated by a wet-drying method, and 25 parts of hydrophilic hydrated fumed silica treated by a wet-drying method;

[0068] S3. Mechanically stirring deuterated chloroform and hydrated fumed silica, and then adding water under mechanical stirring to obtain a concentrated solution.

[0069] Embodiment 7:

[0070] S1. The hydrophobic and hydrophilic hydrated fumed silica were treated by a wet-drying method to obtain a packing density of 250 mg / cm 3 , residual moisture does not exceed 50mg / g;

[0071] The hydrophobic hydrated fumed silica was AM-1 (methyl silica) purchased from Wacker;

[0072] The hydrophilic hydrated fumed silica was fumed silica A-300 purchased from Wacker;

[0073] S2, prepare the following raw materials in parts by weight: 60 parts of n-decane, 40 parts of water, 60 parts of hydrophobic hydrated fumed silica treated by a wet-drying method, and 40 parts of hydrophilic hydrated fumed silica treated by a wet-drying method;

[0074] S3. Mechanically stirring deuterated chloroform and hydrated fumed silica, and then adding water under mechanical stirring to obtain a concentrated solution.

[0075] Comparative Example 1:

[0076] The only difference from Example 1 is that the raw material does not contain non-polar hydrocarbons.

[0077] Comparative Example 2:

[0078] The only difference from Example 1 is that the raw material does not contain hydrated fumed silica.

[0079] Table 1: Properties of concentrated solutions prepared in Examples 1-7 and Comparative Examples 1-2

[0080]

[0081]

[0082] Figure 1 The results of the study of water and water-organic mixtures in the presence of hydrophilic fumed silica are shown. Figure 1 a), the spectrum records a single broad signal of water protons, whose chemical shift (δ Η ) is close to 5ppm. Because the adsorption to the silica surface reduces the free energy of water, the water in the gaps between silica particles will not freeze at temperatures <273K. The non-freezing water in the hydrated powder is in a quasi-liquid state over a wide temperature range, up to 199K ( Figure 1 a). The magnitude of the chemical shift for adsorbed water is close to that for normal liquid water as described above. As the temperature decreases, the magnitude of the chemical shift increases slightly due to the increased order of the interfacial water, while the signal intensity decreases as the water freezes because it is increasingly affected by the surface.

[0083] Tritiated chloroform (CDCl3) can prevent the δ Η =7ppm. A strong chloroform proton signal appears at 1g / g hydrated silica powder added to deuterated chloroform (CDCl3) medium, the silica-water-chloroform system will not be stratified, and the suspension will exist in a closed container indefinitely in a stable form. The binding of water to the silica surface is slightly reduced, and at a temperature of around T = 273K, the proportion of dissolved water increases ( Figure 1 b).

[0084] The freezing / thawing process of localized interfacial water in a solid porous matrix is ​​based on the change in Gibbs free energy due to surface effects. The farther the studied water layer is from the surface, the smaller its Gibbs free energy. At T = 273K, water begins to freeze, and its properties are no different from those of ordinary liquid water per unit volume. As the temperature decreases (without considering the supercooling effect), the water layer closer to the surface will freeze. For interfacial water, the following relationship applies:

[0085] ΔG ice = -0,036(273,15 -Τ), (1)

[0086] The numerical coefficient is a parameter related to the temperature coefficient of the Gibbs free energy change of ice. Plot the relationship between the Gibbs free energy change and the concentration of unfrozen water (G(C uw )) and calculate the number of strongly bound water and weakly bound water (SBW and WBW, respectively, C uw S C uw W etc.) and the thermodynamic properties of these water layers.

[0087] The interfacial binding energy of a solid or biopolymer refers to the total decrease in the free energy of water absorption due to the existence of the internal water-polymer interface. The calculation formula is:

[0088]

[0089] in:

[0090] The interfacial binding energy value is a suitable parameter that can be used to compare the water binding energies in different systems, especially when the amount of water in the system is the same.

[0091] The Gibbs-Thomson equation relates the radius (R) of a spherical or cylindrical pore to the value of the solidification temperature depression and can be used to determine the geometric dimensions of the solid surface of a nanoscale liquid aggregate:

[0092]

[0093] Among them, T m (R) – melting temperature of ice in a pore with radius R; T m,∞ – melting point of ice per unit volume; ρ – density of solid; σ sl – The interaction energy between the solid and the liquid; ΔH f – Enthalpy of fusion. Figure 2 The temperature dependence of the non-freezing water concentration and the dependence of the Gibbs free energy change on the non-freezing water concentration based on this are shown. Figure 2 a), and the radius distribution of non-freezing water clusters in concentrated silica suspensions in air and deuterated chloroform (CDCl3) media ( Figure 2 , b).

[0094] The Gibbs-Thomson relation (3) can be used to estimate the size of nanodroplets during the melting of a solution. In wetted powders of hydrated compacted silica, water exists in the form of clusters (domains) with a radius of 0.4-30 nm. Two maxima at R = 2 and 10 nm can be marked on the distribution diagram ( Figure 2 b) Chloroform media significantly changes the cluster composition of adsorbed water. Due to the formation of large water domains or nano-water droplets with a radius of up to 20nm, the number of small water clusters decreases sharply. This indicates that chloroform displaces adsorbed water from the surface of silica. That is, the affinity of chloroform for the hydrophilic silica surface is comparable to that of water. Even in the case of high hydration, part of the chloroform can diffuse into the narrow interparticle gaps and replace the adsorbed water therein. The schematic diagram of this process is shown in Figure 2 As shown in b.

[0095] When trifluoroacetic acid is added to the dispersion medium ( Figure 1c), trifluoroacetic acid is soluble in chloroform and in water adsorbed on the surface of silica. Due to the dissolution effect, the freezing (melting) temperature of the acid solution is lower than that of pure water. This shows that in most binary solutions, the water-acid solution will form crystals of each component during the freezing process. Then the initial stage of the solution melting will be the melting of crystals of a single substance, which will then mix to form a solution. The possibility of recording separate water-acid signals in a heterogeneous system prepared on the basis of nanosilica should be related to the presence of a water cluster system on the surface of silica, which dissolves the acid in different ways. In this water cluster system, the distance between different clusters is far enough to provide conditions for the slow replacement of molecules (or protons).

[0096] Therefore, in the presence of nano-silica, concentrated water-chloroform solutions that are stable on the surface of the silica particles are easily formed in the interstitial space of the solid particles. These mixtures are very stable and can be used to prepare mixed systems containing other organic substances (such as organic acids), many of which can be used in cosmetic or medical practice.

[0097] Table 2: Characteristics of non-freezing water layer of samples prepared based on hydrated compacted nano-silica under different environments

[0098]

[0099] Table 1 lists the thermodynamic properties of water in concentrated silica suspensions containing 0.4 g / g water in different media. It can be seen from the table that water is in a surface-bound state, and its interaction energy in the air medium is three times that in the chloroform medium. That is, the water in the ternary system is closer to ordinary water in nature, which is undoubtedly an advantage for using such systems as universal solvents and extractants.

[0100] The silica-water-chloroform suspension is sufficiently stable even when the hydrophilic silica is replaced by a hydrophobic silica, which in this case is wetted with water by mechanical treatment. Figure 3 a shows the hydrated silica powder AM-1 (methyl silica) at different temperatures 1 H NMR spectrum, where the water content in the dechloroform medium obtained from 1 g / g silica is twice that of dry silica; Figure 3 b is a composite system of a 2:1 mixture of hydrophilic and hydrophobic silica.

[0101] from Figure 3 The data show that the water in the gaps between silica particles exists in the form of clusters, in which the hydrogen bond network structure is close to that of liquid water (chemical shift δH = 5-6.5ppm). Figure 3a), the spectrum also records the signal of weakly bound water, which does not participate in the formation of hydrogen bonds. This water may be part of the chloroform hydrate that stabilizes the stable phase of the complex heterogeneous system.

[0102] Another nonpolar organic compound, H-decane, behaves similarly to chloroform. Figure 4 The results show the effects of water and decane in suspensions prepared from a mixture of hydrophilic and hydrophobic silica. 1 H NMR spectrum. When the concentration ratio of each component and the temperature change range are large, the colloidal system is a suspension that exists in a stable state stabilized by hydrates formed on the surface of solid particles and at the interface between the aqueous phase and the organic phase.

[0103] In summary, the present invention uses a gel prepared from hydrophilic or hydrophobic silica hydrate powder or a mixture thereof as the basis of a medical and cosmetic gel system, wherein the dispersion medium is a non-polar hydrocarbon chloroform, n-decane or other hydrocarbons with similar physicochemical properties, and the gel concentrated solution can dissolve both polar and non-polar bioactive substances.

[0104] The parts of the embodiments herein that are not exhaustive of the midpoint values ​​of the technical scope claimed for protection by the present invention and the new technical solutions formed by equivalent replacement of single or multiple technical features in the technical solutions of the embodiments are also within the scope claimed for protection by the present invention; at the same time, in all the listed or unlisted embodiments of the scheme of the present invention, each parameter in the same embodiment merely represents an example of its technical solution (i.e., a feasible solution), and there is no strict coordination and limitation relationship between the parameters, wherein the parameters can be replaced with each other without violating the axioms and the claims of the present invention, unless otherwise stated.

[0105] The technical means disclosed in the scheme of the present invention are not limited to the technical means disclosed in the above technical means, but also include technical schemes composed of any combination of the above technical features. The above is a specific implementation of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications are also regarded as the protection scope of the present invention.

[0106] The specific embodiments described herein are merely examples of the spirit of the present invention. Those skilled in the art may make various modifications or additions to the specific embodiments described or replace them in similar ways, but they will not deviate from the spirit of the present invention or exceed the scope defined by the appended claims.

Claims

1. A concentrated solution of non-polar organic matter and water stabilized by fumed silica, characterized in that: The concentrated solution comprises the following raw materials in parts by mass: 3-120 parts of non-polar hydrocarbons, 3-120 parts of water, and 30-150 parts of hydrated fumed silicon dioxide.

2. The method of claim 1 for stabilizing a concentrated solution of non-polar organic matter and water using fumed silica, characterized in that: The concentrated solution comprises the following raw materials in parts by weight: 55-65 parts of non-polar hydrocarbons, 30-50 parts of water, and 80-120 parts of hydrated fumed silica.

3. The method of claim 1 for stabilizing a concentrated solution of non-polar organic matter and water using fumed silica, characterized in that: The non-polar organic matter includes at least one of decane and deuterated chloroform.

4. The method of claim 1 for stabilizing a concentrated solution of non-polar organic matter and water using fumed silica, characterized in that: The particle size of the silicon dioxide particles is 0.5-50 μm.

5. The method of claim 1 for stabilizing a concentrated solution of non-polar organic matter and water using fumed silica, characterized in that: The silica includes at least one of hydrophilic hydrated fumed silica and hydrophobic hydrated fumed silica.

6. A method of stabilizing a concentrated solution of non-polar organic matter and water using fumed silica according to claim 1 or 5, characterized in that: The silica is a hydrophilic hydrated fumed silica and a hydrophobic hydrated fumed silica in a mass ratio of (1-5):(5-1).

7. A method for preparing a concentrated solution of non-polar organic matter and water stabilized by using fumed silica as claimed in claim 1, characterized in that: The method comprises the following steps: S1. Prepare raw materials; S2, treating the hydrated fumed silica by a wetting-drying method; S3. The hydrated fumed silica and the non-polar hydrocarbon are then mechanically mixed and water is added to obtain a concentrated solution.

8. The method for preparing a concentrated solution of non-polar organic matter and water by stabilizing it with fumed silica according to claim 7, characterized in that: Silica particle size and volume density C after wetting-drying method d =210-250mg / cm3, residual moisture content C H2O ≤50mg / g.

9. The method for preparing a concentrated solution of non-polar organic matter and water by stabilizing it with fumed silica according to claim 7, characterized in that: Mechanical mixing includes one of mechanical stirring and ultrasonic treatment.

10. Use of the concentrated solution according to claim 1 or the concentrated solution prepared by the method according to claim 7 in cosmetics, medical materials and extractants.

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