Moxa stick for regulating yin and yang as well as preparation method and application of moxa stick

Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to a moxa stick for yin-yang harmonization and a preparation method and application thereof. The invention provides a moxa stick for regulating yin and yang. The moxa stick is prepared from the following components in parts by mass: 70-80 parts of moxa, 8-12 parts of fructus piperis longi, 5-9 parts of rhizoma atractylodis macrocephalae, 10-16 parts of roasted ginger, 4-10 parts of honey-fried licorice root, 2-6 parts of radix aucklandiae, 1-4 parts of an adhesive and 1-4 parts of water. The moxa floss is prepared from the vinegar-fried wormwood leaves and the wormwood stems according to a certain proportion, and the moxa floss is inflammable, not prone to flames, fragrant in smell and not pungent; the fructus piperis longi, the rhizoma atractylodis macrocephalae, the stewed ginger, the honey-fried licorice root, the radix aucklandiae and the moxa are used together, so that deficiency-cold in spleen and stomach caused by kidney-yang deficiency can be effectively relieved.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a moxa stick for harmonizing yin and yang and a preparation method and application thereof. Background Art

[0002] Yin-Yang imbalance refers to both symptoms and pathogenesis. It is a general term for the loss of balance between the growth and decline of Yin and Yang in the body. It is the pathological change that Yin cannot control Yang and Yang cannot control Yin due to the action of pathogens during the course of the disease. Yin-Yang imbalance is also a summary of the imbalance of the relationship between the internal organs, meridians, Qi and blood, as well as the abnormal movement of Qi such as entering and exiting the inside and outside, rising and falling; including the dominance of Yin and Yang, the decline of Yin and Yang, the mutual loss of Yin and Yang, the rejection of Yin and Yang, the loss of Yin and Yang, and the separation of Yin and Yang. Among them, the decline of Yin and Yang includes Yang deficiency and Yin deficiency; Yang deficiency refers to the pathological state of the body's Yang Qi deficiency, functional decline, low body reactivity, decreased metabolic activity, and insufficient heat. It is mostly caused by insufficient innate endowment, or acquired malnutrition; or the excessive Yin and cold evil injuring Yang, or the misuse or overuse of cold and cool products injuring Yang. If the yang deficiency is kidney yang deficiency, the yang in the kidneys is weak and cannot adequately warm the spleen, which leads to decreased spleen and stomach function and thus spleen and stomach weakness.

[0003] In the prior art, the common method for treating weak spleen and stomach is long-term conditioning with traditional Chinese medicine; however, the medicine is bitter, and some patients find it difficult to take it for a long time. In addition, the process of boiling the medicine is cumbersome and takes a long time. Some patients find it troublesome and will give up using medicine for treatment; people will also choose moxibustion for conditioning. Currently, the moxa sticks used in moxibustion are often single mugwort, and the efficacy of the medicine is poor; the effect is not targeted, and water is often used as a binder when making moxa sticks, which easily causes the moxa sticks to deteriorate, and traditional moxa sticks are generally small in diameter, which are often insufficient when used for a long single course of treatment.

[0004] Therefore, there is an urgent need for a composition that can effectively regulate spleen and stomach weakness. Summary of the invention

[0005] The purpose of the present invention is to provide a moxa stick for regulating yin and yang, which can effectively relieve spleen and stomach weakness.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] The invention provides a moxa stick for regulating yin and yang, which is prepared from the following components in parts by weight: 70-80 parts of moxa floss, 8-12 parts of longan, 5-9 parts of atractylodes macrocephala, 10-16 parts of stewed ginger, 4-10 parts of roasted liquorice, 2-6 parts of costusroot, 1-4 parts of adhesive and 1-4 parts of water.

[0008] Preferably, the moxa comprises vinegar-fried moxa leaves and moxa stems;

[0009] The mass ratio of the vinegar-fried mugwort leaves to the mugwort stems is 15-25:1.

[0010] Preferably, the adhesive is peach gum powder and / or gum arabic.

[0011] The present invention also provides a method for preparing the moxa stick, comprising the following steps:

[0012] (1) Mixing Piper longum, Atractylodes macrocephala, stewed ginger, roasted liquorice, and costusroot, and grinding to obtain a mixed powder;

[0013] (2) mixing the adhesive and water to obtain a glue;

[0014] (3) Mix the mixed powder, glue and moxa, press and shape, and dry to obtain moxa stick.

[0015] Preferably, in step (1), the particle size of the crushed product is 50 to 70 meshes;

[0016] In step (2), the mixing temperature is 90-100°C.

[0017] Preferably, in step (3), the drying temperature is 40 to 60° C. and the drying time is 60 to 80 minutes.

[0018] The present invention also provides a moxibustion composition for regulating yin and yang, the moxibustion composition comprising the moxa stick and the salt complex;

[0019] The salt complex includes green onion and green salt;

[0020] The mass ratio of the scallion white to the green salt is 1:3-9.

[0021] The present invention also provides the use of the moxa stick and the moxibustion composition for regulating yin and yang in preparing products for regulating yin and yang imbalance and spleen and stomach coldness.

[0022] The present invention also provides a moxibustion cotton pad for regulating yin and yang, the moxibustion cotton pad comprising a fleece layer and a permeable layer;

[0023] The fleece layer includes the salt complex;

[0024] The permeable layer includes the moxa stick.

[0025] Beneficial effects of the present invention:

[0026] The invention provides a moxa stick for regulating yin and yang, wherein vinegar-fried moxa leaves and moxa stems are used to prepare moxa wool in a certain proportion, the moxa wool is flammable and not easy to ignite, has a fragrant smell and is not pungent, and the vinegar-fried moxa leaves also enhance the effect of the moxa wool, which is more conducive to dispelling wind and cold, and warming and unblocking meridians; the moxa stick is prepared by mixing longevity, atractylodes macrocephala, stewed ginger, roasted licorice, costus root and moxa wool, and longevity and atractylodes macrocephala are used in combination, which has the effect of warming the middle and strengthening the spleen, and can effectively relieve the spleen and stomach deficiency and cold caused by kidney yang deficiency; stewed ginger, roasted licorice and costus root are used in combination, which has the effect of strengthening the spleen and stomach, and replenishing qi and nourishing yin; the prepared moxa stick can effectively relieve the spleen and stomach deficiency and cold caused by kidney yang deficiency;

[0027] The present invention also provides a moxibustion composition for regulating yin and yang, which includes not only the moxa stick described above, but also a salt complex. The salt complex is prepared by combining scallion white and green salt. During the moxibustion process, moxibustion is performed through the salt complex, which can enhance the effect of the moxa stick and give full play to the effects of scallion white and green salt, thereby improving the relief effect on spleen and stomach deficiency and cold; it can also solve the problem of burns caused by excessive moxibustion temperature. DETAILED DESCRIPTION

[0028] The present invention provides a moxa stick for regulating yin and yang, which is prepared from the following components in parts by mass:

[0029] 70-80 parts of moxa, preferably 73-77 parts, more preferably 75 parts;

[0030] 8 to 12 parts of Piper longum, preferably 9 to 11 parts, more preferably 10 parts;

[0031] 5-9 parts of Atractylodes macrocephala, preferably 6-8 parts, more preferably 7 parts;

[0032] 10 to 16 parts of stewed ginger, preferably 12 to 14 parts, more preferably 13 parts;

[0033] 4 to 10 parts of licorice root, more preferably 6 to 8 parts, more preferably 7 parts;

[0034] 2 to 6 parts of costusroot, preferably 3 to 5 parts, more preferably 4 parts;

[0035] 1 to 4 parts of adhesive, preferably 2 to 3 parts, more preferably 2.5 parts;

[0036] 1 to 4 parts of water, preferably 2 to 3 parts, more preferably 2.5 parts.

[0037] In the present invention, the moxa comprises vinegar-fried moxa leaves and moxa stems;

[0038] The mass ratio of the vinegar-fried mugwort leaves to the mugwort stems is 15 to 25:1, preferably 18 to 22:1, and more preferably 20:1;

[0039] The method for preparing vinegar-fried mugwort leaves comprises the following steps: mixing mugwort leaves and rice vinegar and soaking them for 50 to 70 minutes, and frying them until dry to obtain vinegar-fried mugwort leaves;

[0040] The mass ratio of the wormwood leaf and the rice vinegar is 1:0.1-0.2, more preferably 1:0.15;

[0041] The soaking time is preferably 55 to 65 minutes, more preferably 60 minutes.

[0042] In the present invention, the adhesive is peach gum powder and / or gum arabic, preferably peach gum powder and gum arabic; the mass ratio of peach gum powder to gum arabic is 1:0.5-1.5, more preferably 1:1.

[0043] In the present invention, the preparation method of the stewed ginger comprises: slicing ginger to obtain ginger slices; mixing salt and ginger to obtain a mixture; wrapping the mixture with wet paper, and baking at 90 to 110° C. for 20 to 40 minutes to obtain stewed ginger;

[0044] The thickness of the ginger slices is 0.5 to 1 cm, preferably 0.7 to 0.8 cm, and more preferably 0.75 cm;

[0045] The mass ratio of the salt to the ginger is 10:1-4, preferably 10:2-3, and more preferably 10:2.5;

[0046] The baking temperature is preferably 95-105°C, more preferably 100°C;

[0047] The baking time is preferably 25 to 35 minutes, more preferably 30 minutes.

[0048] The preparation method of the roasted licorice root comprises: slicing raw licorice root to obtain slices, mixing the slices with honey and water and soaking them for 20 to 30 minutes to obtain a mixture; frying the mixture for 30 to 50 minutes to obtain the roasted licorice root;

[0049] The thickness of the slice is 0.5 to 1 cm, preferably 0.7 to 0.8 cm, and more preferably 0.75 cm;

[0050] The mass ratio of the slices to honey and water is 7-9:1-3:1, preferably 8:2:1;

[0051] The soaking time is preferably 23 to 27 minutes, more preferably 25 minutes; the frying time is preferably 35 to 45 minutes, more preferably 40 minutes.

[0052] The present invention also provides a method for preparing the moxa stick, comprising the following steps:

[0053] (1) Mixing Piper longum, Atractylodes macrocephala, stewed ginger, roasted liquorice, and costusroot, and grinding to obtain a mixed powder;

[0054] (2) mixing the adhesive and water to obtain a glue;

[0055] (3) Mix the mixed powder, glue and moxa, press and shape, and dry to obtain moxa stick.

[0056] In the present invention, in step (1), the particle size of the crushed material is 50 to 70 mesh, preferably 55 to 65 mesh, and more preferably 60 mesh;

[0057] In step (2), the mixing temperature is 90-100°C, preferably 93-97°C, and more preferably 95°C.

[0058] In step (3), the drying temperature is 40-60°C, preferably 45-55°C, and more preferably 50°C; the drying time is 60-80 min, preferably 65-75 min, and more preferably 70 min.

[0059] The present invention also provides a moxibustion composition for regulating yin and yang, the moxibustion composition comprising the moxa stick and the salt complex;

[0060] The salt complex includes green onion and green salt;

[0061] The mass ratio of the scallion white to the green salt is 1:3-9, preferably 1:5-6, and more preferably 1:5.5.

[0062] In the present invention, the method for preparing the salt complex comprises the following steps: drying the green onion, mixing it with green salt, and crushing it to obtain the salt complex;

[0063] The method for drying the scallion white is vacuum freeze drying; the vacuum degree of the drying is 6-10Pa, preferably 7-9Pa, and more preferably 8Pa;

[0064] The vacuum freeze drying includes precooling and low-temperature drying; the precooling temperature is -10 to -20°C, preferably -13 to -17°C, and more preferably -15°C; the precooling time is 10 to 20 minutes, preferably 13 to 17 minutes, and more preferably 15 minutes; the low-temperature drying temperature is 30 to 40°C, preferably 33 to 37°C, and more preferably 35°C; the low-temperature drying time is 20 to 30 minutes, preferably 23 to 27 minutes, and more preferably 25 minutes;

[0065] The particle size of the pulverized material is 40 to 60 mesh, preferably 45 to 55 mesh, and more preferably 50 mesh.

[0066] The present invention also provides the use of the moxa stick and the moxibustion composition for regulating yin and yang in preparing products for regulating yin and yang imbalance and spleen and stomach coldness.

[0067] The present invention also provides a moxibustion cotton pad for regulating yin and yang, the moxibustion cotton pad comprising a fleece layer and a permeable layer;

[0068] The fleece layer includes the salt complex;

[0069] The permeable layer includes the moxa stick.

[0070] In the present invention, the thickness of the fleece layer is 2 to 5 mm, preferably 3 to 4 mm, and more preferably 3.5 mm.

[0071] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0072] Example 1

[0073] Preparation of vinegar-fried mugwort leaves: 100g of mugwort and 15g of rice vinegar are mixed and soaked for 60min, and then fried to dry to obtain vinegar-fried mugwort leaves.

[0074] Preparation of stewed ginger: 25 g of ginger was sliced ​​to a thickness of 0.75 cm, and then mixed with 100 g of salt to obtain a mixture; the mixture was wrapped with wet paper and baked at 110° C. for 30 minutes to obtain stewed ginger;

[0075] Preparation of roasted licorice root: 16g of raw licorice root was sliced ​​to a thickness of 0.75cm, and then mixed with 4g of honey and 2g of water and soaked for 25min to obtain a mixture; the mixture was fried for 40min to obtain roasted licorice root;

[0076] Preparation of moxa stick for regulating yin and yang:

[0077] (1) 10 g of Piper longum, 7 g of Atractylodes macrocephala, 13 g of stewed ginger, 7 g of roasted licorice, and 4 g of costusroot were mixed and crushed to a particle size of 60 mesh to obtain a mixed powder;

[0078] (2) 2.5 g of an adhesive (peach gum powder and gum arabic mixed in a mass ratio of 1:1) and 2.5 g of water were mixed at 95° C. to obtain a glue paste;

[0079] (3) The mixed powder, the glue and 75 g of moxa (a mixture of vinegar-fried moxa leaves and moxa stems in a ratio of 20:1) were mixed, pressed into a shape, and dried at 50° C. for 70 min to obtain moxa sticks.

[0080] Preparation of salt complex: Set the vacuum degree to 8 Pa, precool 10 g of green onion at -15°C for 15 min, then low-temperature dry at 35°C for 25 min, mix with 55 g of green salt, and crush to a particle size of 50 mesh to obtain a salt complex.

[0081] Example 2

[0082] The preparation of vinegar-fried mugwort leaves, stewed ginger, and roasted licorice is the same as in Example 1;

[0083] A preparation method of moxa stick for regulating yin and yang:

[0084] (1) 8 g of Piper longum, 6 g of Atractylodes macrocephala, 16 g of stewed ginger, 5 g of roasted licorice, and 6 g of costusroot were mixed and crushed to a particle size of 55 mesh to obtain a mixed powder;

[0085] (2) 4 g of an adhesive (peach gum powder and gum arabic mixed in a mass ratio of 1:1.5) and 1.5 g of water were mixed at 90° C. to obtain a glue paste;

[0086] (3) The mixed powder, the glue and 80 g of moxa (a mixture of vinegar-roasted moxa leaves and moxa stems in a ratio of 15:1) were mixed, pressed into a shape, and dried at 40° C. for 80 min to obtain moxa sticks.

[0087] Preparation of salt complex: Set the vacuum degree to 10Pa, precool 10g of green onion at -10℃ for 20min, then low-temperature dry at 30℃ for 30min, mix with 40g of green salt, and crush to a particle size of 60 mesh to obtain a salt complex.

[0088] Example 3

[0089] The preparation of vinegar-fried mugwort leaves, stewed ginger, and roasted licorice is the same as in Example 1;

[0090] A preparation method of moxa stick for regulating yin and yang:

[0091] (1) Mix 12 g of Piper longum, 9 g of Atractylodes macrocephala, 12 g of stewed ginger, 8 g of roasted licorice, and 2 g of costusroot, and grind to a particle size of 70 mesh to obtain a mixed powder;

[0092] (2) 2 g of a binder (peach gum powder and gum arabic mixed in a mass ratio of 1:0.5) and 3 g of water were mixed at 100° C. to obtain a glue paste;

[0093] (3) The mixed powder, the glue and 70 g of moxa (a mixture of vinegar-roasted moxa leaves and moxa stems in a ratio of 25:1) were mixed, pressed into a shape, and dried at 60° C. for 60 min to obtain moxa sticks.

[0094] Preparation of salt complex: Set the vacuum degree to 6Pa, precool 10g of green onion at -20℃ for 10min, then low-temperature dry at 40℃ for 20min, mix with 70g of green salt, and crush to a particle size of 40 mesh to obtain a salt complex.

[0095] Comparative Example 1

[0096] The difference from Example 1 is that the stewed ginger is replaced with fresh ginger, and the other steps are the same as Example 1.

[0097] Comparative Example 2

[0098] The difference from Example 1 is that the roasted licorice is replaced by raw licorice, and the other steps are the same as those in Example 1.

[0099] Comparative Example 3

[0100] Difference from Example 1: No Atractylodes macrocephala is added, and other steps are the same as in Example 1.

[0101] Comparative Example 4

[0102] The difference from Example 1 is that the vinegar-fried mugwort leaves are replaced with mugwort leaves, and the other steps are the same as Example 1.

[0103] Experimental Example 1

[0104] The salt complexes in Example 1 and Comparative Examples 1 to 4 were respectively placed in cotton cloth with a thickness of 2 mm.

[0105] Mouse modeling: 40 Kunming mice (purchased from Nanjing Junke Bioengineering Co., Ltd.) were selected and, after 2 days of adaptive feeding, randomly divided into a blank control group and a model group (5 mice in the blank control group and 35 mice in the model group); the mice in the model group were intraperitoneally injected with 0.4 mg / mL estradiol benzoate diluted in soybean oil at a body weight of 0.2 mL / 10 g, once a day for 15 consecutive days, to establish a kidney yang deficiency model as the model group; the blank control group was intraperitoneally injected with normal saline at a body weight of 0.2 mL / 10 g, once a day for 15 consecutive days;

[0106] The kidney-yang deficiency model mice were divided into 7 groups: a model control group, Example 1 group, Comparative Example 1 group, Comparative Example 2 group, Comparative Example 3 group, Comparative Example 4 group and a moxa stick group;

[0107] The blank control group and the model control group were not treated. The moxa sticks and salt complexes described in Example 1, Comparative Example 1, Comparative Example 2, Comparative Example 3, and Comparative Example 4 were used to perform moxibustion on the abdomen of mice, respectively. The moxa stick group was moxibustioned using the moxa sticks described in Example 1 (without using the salt complex), moxibustioned once a day for 5 minutes each time, and moxibustioned continuously for 8 days, and the general conditions of the mice in each group were observed and recorded.

[0108] The results showed that the model control group had dull erect hair on the back that was easy to fall off, thin body shape, fatigue, slow reaction, hunched back, loss of appetite, fear of cold, perianal contamination, loose stools; while the mice in Example 1 group and the blank control group had good mental state, normal appetite, normal body temperature, dry and smooth fur, normal activities, flexible reaction to the external environment, preferred to move rather than lie down, and gained weight; the mice in comparative examples 1 to 4 and the moxa stick group had improved conditions compared with the mice in the model control group, but the improvement effect was significantly less than that of the mice in Example 1 group; the mice in the moxa stick group had burns; it can be seen that the moxa stick and salt complex described in Example 1 can significantly improve kidney yang deficiency.

[0109] Example 2

[0110] Orbital blood was collected from mice in Example 1, Comparative Examples 1 to 4, the moxa stick group, the blank control group and the model control group, and the serum creatinine content (SCr) of the mice was determined by the picric acid method, and the urease method was used to determine the urea nitrogen content (BUN) of the mice. The results are shown in Table 1.

[0111] Table 1 Results of determination of creatinine and urea nitrogen content in mice in each group

[0112] SCr(μmol / L) BUN (mmol / L) Blank control group 79.86 8.16 Model control group 98.64 9.94 Example 1 Group 80.67 8.24 Comparative Example 1 90.95 9.09 Comparative Example 2 94.83 9.41 Comparative Example 3 96.54 9.68 Comparative Example 4 82.27 8.49 Moxa stick group 81.29 8.37

[0113] As can be seen from Table 1, the creatinine and urea nitrogen levels of mice in the model control group were significantly higher than those of mice in the blank control group;

[0114] The creatinine and urea nitrogen levels of the mice in the Example 1 group, the Comparative Examples 1 to 4, and the moxa stick group all showed a downward trend, but the creatinine and urea nitrogen levels of the mice in the Example 1 group were significantly lower than those in the other groups, and there was no significant difference with the blank control group. It can be seen that the moxa stick and salt complex described in Example 1 of the present invention can effectively alleviate kidney yang deficiency.

[0115] Experimental Example 3

[0116] 50 patients diagnosed with spleen and stomach weakness caused by kidney-yang deficiency were selected and treated with the moxa stick and salt complex described in Example 1;

[0117] Specific treatment method: put the salt complex into cotton cloth as a fleece layer with a thickness of 2mm, and use moxa sticks as a penetration layer to prepare a cotton pad for moxibustion; light the moxa sticks and perform moxibustion through the fleece layer, 3 times a week, 60 minutes each time; 2 weeks as a course of treatment, 4 courses of treatment are used continuously;

[0118] The treatment status of the patients was statistically analyzed and the results are shown in Table 2.

[0119] Table 2 Treatment results of cases of spleen and stomach weakness caused by kidney yang deficiency

[0120]

[0121] It can be seen from Table 2 that after 4 courses of treatment with the moxa stick and salt complex described in Example 1, the cure rate of patients with spleen and stomach weakness caused by kidney yang deficiency was 58%, the significant effective rate was 30%, the improvement rate was 8%, and the total effective rate was 96%; it can be seen that the moxa stick and salt complex described in the present invention can effectively alleviate spleen and stomach weakness caused by kidney yang deficiency.

[0122] It can be seen from the above embodiments that the present invention provides a moxa stick for balancing yin and yang and a preparation method and application thereof. The moxa stick of the present invention can effectively relieve spleen and stomach weakness.

[0123] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A moxa stick for regulating yin and yang, characterized in that: The invention is prepared from the following components in parts by weight: 70-80 parts of moxa, 8-12 parts of longan, 5-9 parts of atractylodes, 10-16 parts of stewed ginger, 4-10 parts of roasted licorice, 2-6 parts of costusroot, 1-4 parts of adhesive and 1-4 parts of water.

2. The moxa stick according to claim 1, characterized in that The moxa comprises vinegar-fried moxa leaves and moxa stems; The mass ratio of the vinegar-fried mugwort leaves to the mugwort stems is 15-25:

1.

3. The moxa stick according to claim 2, characterized in that The adhesive is peach gum powder and / or gum arabic.

4. The method for preparing the moxa stick according to any one of claims 1 to 3, characterized in that The steps include: (1) Mix Piper longum, Atractylodes macrocephala, stewed ginger, roasted liquorice and costusroot, and grind to obtain a mixed powder; (2) mixing the adhesive and water to obtain a paste; (3) The mixed powder, glue and moxa are mixed, pressed into shape, and dried to obtain moxa sticks.

5. The preparation method according to claim 4, characterized in that: In step (1), the particle size of the crushed product is 50-70 mesh; In step (2), the mixing temperature is 90-100°C.

6. The preparation method according to claim 5, characterized in that: In step (3), the drying temperature is 40-60° C. and the drying time is 60-80 min.

7. A moxibustion composition for regulating yin and yang, characterized in that: The moxibustion composition comprises the moxa stick and salt complex according to any one of claims 1 to 3; The salt complex includes green onion and green salt; The mass ratio of the scallion white to the green salt is 1:3-9.

8. Use of the moxa stick described in any one of claims 1 to 3 and the moxibustion composition for regulating yin and yang described in claim 7 in the preparation of products for regulating yin and yang imbalance and spleen and stomach coldness.

9. A cotton pad for moxibustion used for regulating yin and yang, characterized in that: The moxibustion cotton pad comprises a fleece layer and a permeation layer; The fleece layer comprises the salt complex as claimed in claim 7; The permeable layer comprises the moxa stick described in any one of claims 1 to 3.

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