Continuous granulating and drying all-in-one machine for pharmacy

Abstract

The invention provides a pharmaceutical continuous granulating and drying all-in-one machine, and belongs to the technical field of pharmaceutical equipment, the pharmaceutical continuous granulating and drying all-in-one machine comprises an all-in-one machine main body, and the all-in-one machine main body comprises a feeding mechanism, a granulating mechanism and a drying mechanism which are connected in sequence; the granulating mechanism comprises a double-screw granulator and a feeding pump; and a drying mechanism. A powder material is conveyed to the double-screw granulator through the feeding mechanism, the powder material and a liquid material are mixed in the double-screw granulator to form a wet particle material, and the wet particle material falls onto the air distribution plate through the discharging pipe. Wet particle materials are dried on the air distribution plate, the vibration assembly drives the air distribution plate to obliquely vibrate in a reciprocating mode through the air inlet cavity, and the air distribution plate drives the materials to vibrate and form transmission in the direction from the discharging pipe to the discharging pipe. According to the continuous granulating and drying all-in-one machine for pharmacy provided by the invention, the integrated design of the wet granulator and the continuous drying machine is realized, the defects caused by configuration of transmission equipment between the wet granulator and the continuous drying machine are avoided, and the space utilization rate of the equipment is improved.

Description

Technical Field

[0001] The invention belongs to the technical field of pharmaceutical equipment, and more specifically, relates to a continuous granulation and drying integrated machine for pharmaceutical use. Background Art

[0002] Wet granulation is an emerging continuous granulation technology that offers great flexibility in equipment design and selection of process variables. In continuous production processes, wet granulators have significant advantages over traditional batch production methods such as high shear granulators and fluidized bed granulators. Continuous dryers are new equipment that have gradually developed and expanded in the past decade. Granule drying is also a very important link in continuous production processes because some specific processes can be achieved during the drying process, such as improving fluidity, preventing segregation, and reducing dust. However, there is currently no integrated continuous granulation vibration dryer on the market that can meet pharmaceutical quality requirements from the feeding end to the finished product end.

[0003] In the prior art, a corresponding transmission device is usually set between the wet granulator and the continuous dryer. After the wet granulation, the wet granular material is transported by the transmission device and then enters the continuous dryer for drying, and finally prepared as a finished product. If conventional transmission equipment is used to transport the wet granular material, secondary pollution is likely to occur; if sealed transmission equipment that meets the pharmaceutical cleanliness requirements is used, the manufacturing cost will be greatly increased. Whether conventional transmission equipment or sealed transmission equipment that meets the pharmaceutical cleanliness requirements is used, the overall space occupancy rate will increase, making the working space narrow. Summary of the invention

[0004] The object of the present invention is to provide a continuous granulation and drying integrated machine for pharmaceutical use, which can realize the integrated design of a wet granulator and a continuous dryer, avoid the disadvantages caused by configuring a transmission device between the two, and improve the space utilization of the equipment.

[0005] To achieve the above object, the technical solution adopted by the present invention is: to provide a pharmaceutical continuous granulation and drying integrated machine, including an integrated machine body, wherein the integrated machine body includes a feeding mechanism, a granulation mechanism and a drying mechanism connected in sequence: The feeding mechanism is arranged on the upper part of the integrated machine body and is used for weighing and quantitatively conveying powder materials; The granulation mechanism comprises a twin-screw granulator and a feed pump, the twin-screw granulator is provided with a feed pipe and a discharge pipe, the feed pipe is connected to the feed mechanism and is used to supply powder material to the twin-screw granulator, and the feed pump is used to provide liquid material to the twin-screw granulator; The drying mechanism includes an air inlet chamber and a fluidizing chamber which are connected in sequence from bottom to top, the bottom of the air inlet chamber is connected to a hot air supply component, the top of the air inlet chamber is provided with an air distribution plate, the air distribution plate is used to receive the wet particulate material discharged from the discharge pipe, the top of the fluidizing chamber is provided with a filter component and an exhaust component in sequence from bottom to top, a drop pipe is provided on the side of the air inlet chamber away from the discharge pipe, and a vibration component is provided on the outer wall of one side of the air inlet chamber, the vibration component drives the air distribution plate to tilt and vibrate back and forth, so as to drive the wet particulate material to vibrate and transmit in the direction of the drop pipe.

[0006] In a possible implementation, the twin-screw granulator is horizontally arranged, the feed pipe is connected to the upper end of the twin-screw granulator away from the drying mechanism, the discharge pipe is connected to the lower end of the twin-screw granulator close to the drying mechanism, and the feed pump is connected to the middle upper end of the twin-screw granulator through a pipeline.

[0007] In a possible implementation, a feed filter is provided at an upper end of a side of the twin-screw granulator close to the drying mechanism, and the feed filter is provided directly above the discharge pipe.

[0008] In a possible implementation, a discharge valve is provided in the middle of the discharge pipe, and a particle size detector is installed on the outer wall of the discharge valve. The particle size detector is used to detect the outer diameter of particles of the wet granular material passing through the discharge valve.

[0009] In one possible implementation, the air inlet chamber is a conical chamber with a cross-section decreasing from top to bottom, and the vibration component is arranged on the outer wall of the conical chamber on the side close to the feed pipe. The vibration component provides intermittent vibration inclined upward from the feed pipe to the drop pipe to drive the material on the air distribution plate to move toward the drop pipe.

[0010] In one possible implementation, the hot air supply component includes an air inlet dehumidifier, an air inlet fan and an air inlet heater connected in sequence, the air inlet dehumidifier is used to dry external air and introduce the air into the air inlet heater through the air inlet fan, the air inlet heater is connected to the bottom of the air inlet chamber through an air inlet duct, and an air inlet valve is provided in the air inlet duct.

[0011] In a possible implementation, a partition is horizontally arranged at the upper part of the fluidizing chamber, and the partition divides the fluidizing chamber into an upper chamber and a lower chamber; The filter assembly includes a plurality of filter components, and the plurality of filter components are disposed on the partition plate and communicate with the upper chamber and the upper chamber; The exhaust assembly includes an exhaust duct, a dust collector and an exhaust fan connected in sequence, the exhaust duct is horizontally arranged in the upper chamber, and one end of the exhaust duct extends to the outside of the upper chamber and is connected to the dust collector, and an exhaust valve is arranged at one end of the exhaust duct extending to the upper chamber.

[0012] In a possible implementation, a back-blowing air bag is disposed on the top of the fluidizing chamber, and the back-blowing air bag back-blows the plurality of filter components through the upper chamber.

[0013] In a possible implementation, the drop pipe is provided with a drop valve and a pelletizer in sequence from top to bottom, the pelletizer is located at the lower end of the drop pipe, and a material receiving bucket is provided below the pelletizer.

[0014] In a possible implementation, the blanking pipe is provided with a temperature detector and a moisture detector in sequence from top to bottom, and the temperature detector and the moisture detector are both located above the blanking valve.

[0015] The beneficial effect of the continuous granulation and drying integrated machine for pharmaceutical use provided by the present invention is that: compared with the prior art, the powder material is weighed in the feeding mechanism and quantitatively conveyed to the feeding pipe, the powder material enters the twin-screw granulator through the feeding pipe, the feeding pump provides liquid material to the twin-screw granulator, the powder material and the liquid material are mixed in the twin-screw granulator to form wet granular material, and fall onto the air distribution plate through the discharge pipe. The hot air supply component blows dry hot air from the bottom of the air inlet chamber toward the air distribution plate, and the dry hot air enters the fluidization chamber after passing through the wet granular material on the air distribution plate, and is discharged by the exhaust component after being filtered by the filter component. While the wet granular material is drying on the air distribution plate, the vibration component drives the air distribution plate to tilt and reciprocate through the air inlet chamber, and the air distribution plate drives the material to vibrate and form a transmission from the discharge pipe to the drop pipe. The continuous granulation and drying integrated machine for pharmaceutical use provided by the present invention can realize the integrated design of the wet granulator and the continuous dryer, avoid the disadvantages caused by configuring the transmission equipment between the two, and improve the space utilization rate of the equipment. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0017] Figure 1 A three-dimensional diagram of a continuous granulation and drying machine for pharmaceutical use provided by the present invention; Figure 2A schematic diagram of the structure of a continuous granulation and drying integrated machine for pharmaceutical use provided by the present invention; Figure 3 A schematic diagram of the structure of the air inlet chamber provided by the present invention; Figure 4 A schematic diagram of the material provided by the present invention being transmitted on an air distribution plate.

[0018] In the figure: 1. feeding mechanism; 2. feeding pump; 3. feeding filter; 4. twin-screw granulator; 5. discharging valve; 6. particle size detector; 7. main exciting motor; 8. air distribution plate; 9. filtering component; 10. back-blowing air bag; 11. spray ball; 12. fluidizing chamber; 13. temperature detector; 14. moisture detector; 15. discharge valve; 16. granulator; 17. receiving barrel; 18. air inlet chamber; 19. air inlet valve; 20. air inlet heater; 21. air inlet fan; 22. air inlet dehumidifier; 23. exhaust air duct; 24. exhaust valve; 25. dust collector; 26. exhaust fan; 27. granulating mechanism; 28. drying mechanism; 29. ​​display screen; 30. guide plate; 31. auxiliary exciting motor; 32. hot air connecting pipe; 33. material blocking mesh plate. DETAILED DESCRIPTION

[0019] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0020] Unless explicitly defined otherwise, the use of terms such as "first," "second," or "third," etc., are intended to distinguish different objects rather than to describe a specific order.

[0021] Unless otherwise expressly defined, directional words such as the terms "center", "lateral", "longitudinal", "horizontal", "vertical", "top", "bottom", "inside", "outside", "up", "down", "front", "back", "left", "right", "clockwise", "counterclockwise", "high", "low", etc., indicating directions or positional relationships are based on the directions and positional relationships shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific direction or be constructed and operated in a specific direction, so they cannot be understood as limiting the specific scope of protection of the present invention.

[0022] See also Figure 1 to Figure 2 Now, a pharmaceutical continuous granulation and drying integrated machine provided by the present invention is described. A pharmaceutical continuous granulation and drying integrated machine comprises an integrated machine body, wherein the integrated machine body comprises a feeding mechanism 1, a granulation mechanism 27 and a drying mechanism 28 connected in sequence.

[0023] The feeding mechanism 1 is arranged at the upper part of the integrated machine body and is used for weighing and quantitatively conveying powder materials; The granulating mechanism 27 includes a twin-screw granulator 4 and a feed pump 2. The twin-screw granulator 4 is equipped with a feed pipe and a discharge pipe. The feed pipe is connected to the feed mechanism 1 for supplying powder material to the twin-screw granulator 4. The feed pump 2 is used to supply liquid material to the twin-screw granulator 4. The drying mechanism 28 includes an air inlet chamber 18 and a fluidizing chamber 12 which are connected in sequence from bottom to top. The bottom of the air inlet chamber 18 is connected to a hot air supply component. The top of the air inlet chamber 18 is provided with an air distribution plate 8. The air distribution plate 8 is used to receive the wet granular material discharged from the discharge pipe. The top of the fluidizing chamber 12 is provided with a filter component and an exhaust component in sequence from bottom to top. A drop pipe is provided on the side of the air inlet chamber 18 away from the discharge pipe. A vibration component is provided on the outer wall of one side of the air inlet chamber 18. The vibration component drives the air distribution plate 8 to vibrate back and forth to drive the wet granular material to vibrate and transmit in the direction of the drop pipe.

[0024] The present invention provides a pharmaceutical continuous granulation and drying integrated machine. Compared with the prior art, the powder material is weighed in the feeding mechanism 1 and quantitatively conveyed to the feeding pipe. The powder material enters the twin-screw granulator 4 through the feeding pipe. The feeding pump 2 provides liquid material to the twin-screw granulator 4. The powder material and the liquid material are mixed in the twin-screw granulator 4 to form wet granular material, which falls onto the air distribution plate 8 through the discharge pipe. The hot air supply component blows dry hot air from the bottom of the air inlet chamber 18 toward the air distribution plate 8. The dry hot air passes through the wet granular material on the air distribution plate 8 and enters the fluidization chamber 12. After being filtered by the filter component, it is discharged by the exhaust component. While the wet granular material is drying on the air distribution plate 8, the vibration component drives the air distribution plate 8 to vibrate back and forth through the air inlet chamber 18. The air distribution plate 8 drives the material to vibrate and form a transmission from the discharge pipe to the drop pipe. The invention provides a pharmaceutical continuous granulation and drying integrated machine, which can realize the integrated design of a wet granulator and a continuous dryer, avoids the disadvantages caused by configuring a transmission device between the two, and improves the space utilization rate of the equipment.

[0025] The twin-screw granulator 4 is arranged horizontally, the feed pipe is connected to the upper end of the twin-screw granulator 4 away from the drying mechanism 28, the discharge pipe is connected to the lower end of the twin-screw granulator 4 close to the drying mechanism 28, and the feed pump 2 is connected to the middle upper end of the twin-screw granulator 4 through a pipeline. The powder material enters the feed pipe through the feed mechanism 1, and the feed mechanism 1 has a weighing function and an adjustment function. By weighing the powder material and adjusting the feeding speed into the feed pipe, the powder material entering the twin-screw granulator 4 is preliminarily mixed, and the liquid material is quantitatively added to the twin-screw granulator 4 through the feed pump 2 to mix with the powder material. The liquid material and the powder material will be continuously conveyed, mixed and sheared to finally generate wet granular material, which finally falls onto the air distribution plate 8 through the discharge pipe.

[0026] The feeding mechanism 1 can use a loss-in-weight feeder, which is also called a loss-in-weight feeder or a loss-in-weight scale. It is a device that automatically adjusts the feeder rate by measuring the weight loss rate of the material, thereby achieving uniform, accurate and continuous feeding of the material. It is suitable for a variety of materials such as plastic particles, powders, calcium carbonate, talcum powder, resin film powders, flour, starch, etc., and can realize manual and automatic control of feeding and replenishment processing. The feeding mechanism 1 can also use a spiral feeder, a vibrating feeder or a disc feeder, etc., which needs to have the functions of weighing and quantitative transmission, which will not be repeated here.

[0027] Among them, the feed pump 2 can adopt a peristaltic pump. The peristaltic feed pump is a device that realizes material transportation through the peristaltic principle. The peristaltic pump is suitable for conveying liquids of different properties, suspended solids and high-viscosity media, etc. The flow rate and pressure can be adjusted by adjusting the roller speed or changing the roller position to meet the needs of different working conditions. The flow rate and pressure can also be accurately controlled to achieve precise transportation. The feed pump 2 can also adopt a plunger pump. The plunger pump is a device that realizes material transportation by reciprocating the plunger (piston) in the pump body. The plunger pump can easily adjust the flow rate by adjusting the stroke or speed of the plunger to adapt to different feeding requirements, realize precise feeding control, and provide a higher working pressure. It is suitable for occasions requiring high-pressure feeding.

[0028] A feed filter 3 is provided at the upper end of the twin-screw granulator 4 on the side close to the drying mechanism 28. The feed filter 3 is arranged directly above the discharge pipe. The feed filter 3 can introduce external clean air into the side of the twin-screw granulator 4 close to the drying mechanism 28, thereby balancing the air pressure of the discharge pipe and ensuring that the wet granular material can fall smoothly through the discharge pipe.

[0029] Preferably, a discharge valve 5 is provided in the middle of the discharge pipe, and a particle size detector 6 is installed on the outer wall of the discharge valve 5. The particle size detector 6 is used to detect the outer diameter of the wet granular material passing through the discharge valve 5. The part of the discharge valve 5 located inside the discharge pipe is a rotor structure, which has a plurality of blades evenly distributed circumferentially, and adjacent blades form a discharge cavity. As the rotor rotates, the discharge cavity in the upward opening state receives the material and then rotates to the downward opening state. The material leaves the discharge cavity and finally falls onto the air distribution plate 8. The material feed amount can be controlled by adjusting the rotation speed of the rotor. When the material is transmitted downward through the discharge cavity, the particle size detector 6 will detect the outer diameter of the material particles to ensure that it meets the requirements.

[0030] See also Figure 3 The air inlet chamber 18 is a conical chamber with a cross-section decreasing from top to bottom. The vibration component is arranged on the outer wall of the conical chamber close to the feed pipe. The vibration component provides intermittent vibration inclined upward from the feed pipe to the drop pipe to drive the material on the air distribution plate 8 to move toward the drop pipe.

[0031] A plurality of guide plates 30 are radially arranged inside the conical chamber, and guide channels are formed between adjacent guide plates 30. The width of the guide channels gradually increases from bottom to top. After the dry hot air enters the lower port of the conical chamber, it begins to be divided and enters the multiple guide channels respectively. The dry hot air passes upward through the air distribution plate 8 along the guide channel to dry the material. The distance between the lower port of the guide channel and the lower port of the conical chamber is less than 1 cm. The hot air entering the lower port of the guide channel can be evenly dispersed into the multiple guide channels, avoiding excessive concentration of the dry hot air in the middle of the conical chamber, and achieving uniform conduction of the dry hot air to the air distribution plate 8.

[0032] Preferably, a hot air connecting pipe 32 is provided at the upper end of the air inlet chamber 18 near the drop pipe, and the hot air connecting pipe 32 is connected to the upper end of the drop pipe. A material blocking mesh plate 33 is longitudinally provided in the connection channel between the hot air connecting pipe 32 and the drop pipe, and the material blocking mesh plate 33 can allow the dry hot air to pass through and can block the material from falling from the drop pipe into the air inlet chamber 18. In addition, a bending structure is formed at the upper end of the guide plate 30 near the drop pipe, and the bending structure is bent in the direction of the drop pipe, so that the two guide channels near the drop pipe provide dry hot air to the drop pipe respectively. After the material falls into the drop pipe, the dry hot air is sprayed out through the two guide channels near the drop pipe to further dry the material. At the same time, the material passing through the drop pipe will be blown to the position of the sensing probe of the moisture detector 14 near the side of the air inlet chamber 18, so as to facilitate the accuracy of the moisture detector 14 detection. In addition, the blanking valve 15 is located below the hot air connecting pipe 32. The part of the blanking valve 15 located inside the blanking pipe is a wheel structure, which has a plurality of blades evenly distributed in the circumference, and adjacent blades form a blanking cavity. The blades rotate in a direction away from the air inlet chamber 18. Under the action of the dry hot air passing through the hot air connecting pipe 32, the material passing through the blanking pipe will be concentrated on the side away from the air inlet chamber 18, which can ensure that the material can fill the blanking cavity, so as to ensure the accuracy of the blanking valve 15 in controlling the blanking amount.

[0033] The vibration component is the main excitation motor 7, which is vertically fixed to the outer wall of the conical chamber through a mounting base. After the main excitation motor 7 is started, an intermittent impact force perpendicular to the outer wall of the conical chamber will be generated, and the impact force will be transmitted to the air distribution plate 8 through the air inlet chamber 18, so that the air distribution plate 8 has intermittent vibration in the same direction, and the material on the air distribution plate 8 is tilted and thrown up, and gradually moves toward the direction of the drop pipe. In this process, not only can the material be transmitted, but the material will also be further evenly dispersed to the upper end surface of the air distribution plate 8, which can improve the drying effect of the material.

[0034] Preferably, an auxiliary vibration motor 31 is also provided on the outer wall of the conical chamber away from the feeding pipe. The auxiliary vibration motor 31 is also vertically fixed on the outer wall of the conical chamber through a mounting base. The auxiliary vibration motor 31 can also provide intermittent vibration. The vibration amplitude of the auxiliary vibration motor 31 is smaller than the vibration amplitude of the main vibration motor 7. The vibration frequencies of the main vibration motor 7 and the auxiliary vibration motor 31 are the same, and the auxiliary vibration motor 31 vibrates during the intermittent period of the main vibration motor 7.

[0035] See also Figure 4 After the main excitation motor 7 and the auxiliary excitation motor 31 are started, the main excitation motor 7 will form an intermittent main impact force F perpendicular to the outer wall of the conical chamber. The main impact force F is transmitted to the air distribution plate 8 through the air inlet chamber 18, so that the air distribution plate 8 has intermittent main vibration in the same direction. The material on the air distribution plate 8 is tilted and thrown up, and gradually moves toward the direction of the drop tube. During the intermittent period of the main excitation motor 7, the auxiliary excitation motor 31 vibrates the other side of the conical chamber to form an intermittent auxiliary impact force f. The auxiliary impact force f drives the air distribution plate 8 to vibrate in the opposite direction, and the material that is vibrated and transmitted in the direction of the drop tube is vibrated and transmitted in the opposite direction. Since the vibration amplitude of the auxiliary excitation motor 31 is smaller than the vibration amplitude of the main excitation motor 7, the distance the material returns is smaller than the distance the material advances. The overall transmission direction of the material is still constantly moving toward the direction of the drop tube. The material is repeatedly tilted and thrown up in this process, and can be fully dried.

[0036] The hot air supply assembly includes an air inlet dehumidifier 22, an air inlet fan 21 and an air inlet heater 20 which are connected in sequence. The air inlet dehumidifier 22 is used to dry the external air and introduce the air inlet heater 20 through the air inlet fan 21. The air inlet heater 20 is connected to the bottom of the air inlet chamber 18 through the air inlet duct. The air inlet duct is provided with an air inlet valve 19. The air inlet valve 19 controls the air volume entering the air inlet chamber 18 by controlling its own opening.

[0037] A partition is horizontally arranged at the upper part of the fluidizing chamber 12, and the partition divides the fluidizing chamber 12 into an upper chamber and a lower chamber. The filter assembly includes a plurality of filter components 9, and the plurality of filter components 9 are arranged on the lower end surface of the partition and connected to the upper chamber. The exhaust assembly includes an exhaust duct 23, a dust collector 25 and an exhaust fan 26 connected in sequence, the exhaust duct 23 is horizontally arranged in the upper chamber, and one end of the exhaust duct 23 extends to the outside of the upper chamber and is connected to the dust collector 25, and the exhaust duct 23 is sealed and connected to the upper chamber to ensure the sealing of the upper chamber. An exhaust valve 24 is arranged at one end of the exhaust duct 23 extending to the upper chamber, and the exhaust valve 24 controls its own opening to control the air volume discharged from the exhaust chamber. The hot air passing through the air distribution plate 8 will be mixed with some small particles of the material. After passing through the above-mentioned multiple filter components 9, most of them will be blocked by the filter components 9, and as for smaller particles, they will be collected in the dust collector 25, ensuring that the gas finally discharged through the exhaust fan 26 does not contain any particulate matter, which can reduce the impact of particulate matter on the normal operation of the exhaust fan 26 and reduce pollution to the environment.

[0038] Among them, the filter component 9 can adopt a filter membrane or a filter screen, and the filter membrane or the filter screen is directly installed on the reserved hole of the partition, and the filter membrane or the filter screen can achieve the effect of blocking the passage of powder; the filter component 9 can also adopt a filter cartridge, and the upper port of the filter cartridge is installed on the reserved hole of the partition, and the lower end of the filter cartridge extends downward into the fluidizing chamber. Compared with the filter membrane and the filter screen, the filter cartridge has a larger filtering area.

[0039] The air inlet valve 19 and the air exhaust valve 24 respectively use proportional valves, which can remotely control the pressure, flow or direction of the oil continuously and proportionally according to the input electrical signal. After receiving the electrical signal, the proportional valve can respond quickly and change the pneumatic parameters, thereby achieving precise control of the air intake and exhaust volumes.

[0040] In addition, a plurality of spray balls 11 are provided on the lower end surface of the partition. When the material needs to be replaced, a touch operation can be performed on the display screen 29 of the pharmaceutical continuous granulation and drying machine to spray cleaning liquid into the fluidizing chamber 12 through the spray ball 11, thereby cleaning the air distribution plate 8 and avoiding the mixing of different materials.

[0041] A back-blowing air bag 10 is provided at the top of the fluidizing chamber 12, and the back-blowing air bag 10 back-blows multiple filter components 9 through the upper chamber. When the material particles adhering to the outer wall of the filter component 9 gather more and affect the air permeability of the filter component 9; an air pressure detection unit can also be installed in the fluidizing chamber 12. When the air pressure detection unit detects that the air pressure in the fluidizing chamber 12 exceeds the set value, it means that the air permeability of the filter component 9 does not meet the exhaust requirement. At this time, the back-blowing air bag 10 is turned on, and the back-blowing air bag 10 provides a back-blowing airflow to blow off the material particles adhering to the filter component 9, so as to achieve the effect of cleaning the filter component 9. The back-blowing air bag 10 can complete the cleaning of the filter component 9 without stopping the machine, thereby ensuring the continuity of production.

[0042] The drop pipe is provided with a drop valve 15 and a granulator 16 from top to bottom. The granulator 16 is located at the lower end of the drop pipe, and a receiving bucket 17 is provided below the granulator 16. The part of the drop valve 15 located inside the drop pipe is a rotary structure. The rotary wheel has a plurality of blades evenly distributed in the circumference, and adjacent blades form a drop cavity. As the rotary wheel rotates, the drop cavity with the opening upward receives the material and rotates to the state of opening downward. The material leaves the drop cavity and finally falls into the granulator 16. The amount of material dropped can be controlled by adjusting the rotation speed of the rotary wheel. The granulator 16 is used to further crush, granulate or shape the larger block or lump material. The main function of the granulator 16 is to break up, crush or shape the material by mechanical force to achieve the required particle size and shape. The finished material will fall into the receiving bucket 17, thereby completing the final collection of the material.

[0043] Preferably, the material drop pipe is provided with a temperature detector 13 and a moisture detector 14 from top to bottom, and both the temperature detector 13 and the moisture detector 14 are located above the material drop valve 15. Before the material passes through the material drop valve 15, it passes through the temperature detector 13 and the moisture detector 14 in sequence, thereby completing the detection of the material humidity and the material moisture.

[0044] In addition, the present invention provides a continuous granulation and drying integrated machine for pharmaceutical use, which uses PAT (Process Analytical Technologies) technology to scientifically integrate the granulation mechanism 27 and the drying mechanism 28 into one device, which has a higher space utilization rate than separate devices. The PAT technology can monitor the properties of the material in real time, and the values ​​can be digitally displayed on the display screen 29 of the integrated machine, which is convenient for R&D personnel to control the process according to the quality of the particles (such as particle size distribution, product temperature, moisture), generate reports, and facilitate R&D personnel to conduct research, greatly improving the work efficiency of R&D personnel.

[0045] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A continuous granulation and drying machine for pharmaceutical use, characterized in that: It comprises an integrated machine body, wherein the integrated machine body comprises a feeding mechanism (1), a granulating mechanism (27) and a drying mechanism (28) which are connected in sequence; The feeding mechanism (1) is arranged on the upper part of the integrated machine body and is used for weighing and quantitatively conveying powder materials; The granulating mechanism (27) comprises a twin-screw granulator (4) and a feed pump (2), wherein the twin-screw granulator (4) is provided with a feed pipe and a discharge pipe, wherein the feed pipe is connected to the feed mechanism (1) and is used to supply powder material to the twin-screw granulator (4), and the feed pump (2) is used to supply liquid material to the twin-screw granulator (4); The drying mechanism (28) comprises an air inlet chamber (18) and a fluidizing chamber (12) which are connected in sequence from bottom to top; the bottom of the air inlet chamber (18) is connected to a hot air supply assembly; the top of the air inlet chamber (18) is provided with an air distribution plate (8), and the air distribution plate (8) is used to receive the wet granular material discharged from the discharge pipe; the top of the fluidizing chamber (12) is provided with a filter assembly and an exhaust assembly in sequence from bottom to top; a drop pipe is provided on the side of the air inlet chamber (18) away from the discharge pipe; a vibration assembly is provided on the outer wall of one side of the air inlet chamber (18), and the vibration assembly drives the air distribution plate (8) to vibrate in an inclined reciprocating manner, so as to drive the wet granular material to vibrate and transmit in the direction of the drop pipe.

2. A pharmaceutical continuous granulation and drying integrated machine as claimed in claim 1, characterized in that: The twin-screw granulator (4) is arranged horizontally, the feed pipe is connected to the upper end of the twin-screw granulator (4) away from the drying mechanism (28), the discharge pipe is connected to the lower end of the twin-screw granulator (4) close to the drying mechanism (28), and the feed pump (2) is connected to the middle upper end of the twin-screw granulator (4) through a pipeline.

3. A continuous granulation and drying machine for pharmaceutical use as claimed in claim 2, characterized in that: A feed filter (3) is provided at the upper end of one side of the twin-screw granulator (4) close to the drying mechanism (28), and the feed filter (3) is arranged directly above the discharge pipe.

4. A continuous granulation and drying machine for pharmaceutical use as claimed in claim 2, characterized in that: A discharge valve (5) is arranged in the middle of the discharge pipe, and a particle size detector (6) is installed on the outer wall of the discharge valve (5). The particle size detector (6) is used to detect the outer diameter of the particles of the wet granular material passing through the discharge valve (5).

5. The continuous granulation and drying integrated machine for pharmaceutical use according to claim 1, characterized in that: The air inlet chamber (18) is a conical chamber with a cross-section decreasing from top to bottom. The vibration component is arranged on the outer wall of the conical chamber close to the feeding pipe. The vibration component provides intermittent vibration inclined upward from the feeding pipe to the blanking pipe, so as to drive the material on the air distribution plate (8) to move in the direction of the blanking pipe.

6. A pharmaceutical continuous granulation and drying integrated machine as claimed in claim 5, characterized in that: The hot air supply assembly comprises an air inlet dehumidifier (22), an air inlet fan (21), and an air inlet heater (20) which are connected in sequence. The air inlet dehumidifier (22) is used to dry external air and introduce the air into the air inlet heater (20) through the air inlet fan (21). The air inlet heater (20) is connected to the bottom of the air inlet chamber (18) through an air inlet duct. An air inlet valve (19) is provided in the air inlet duct.

7. The continuous granulation and drying integrated machine for pharmaceutical use according to claim 1, characterized in that: A partition is horizontally arranged at the upper part of the fluidizing chamber (12), and the partition divides the fluidizing chamber (12) into an upper chamber and a lower chamber; The filter assembly comprises a plurality of filter components (9), wherein the plurality of filter components (9) are arranged on the partition plate and communicate with the upper chamber and the lower chamber; The exhaust assembly comprises an exhaust duct (23), a dust collector (25) and an exhaust fan (26) which are connected in sequence; the exhaust duct (23) is horizontally arranged in the upper chamber, and one end of the exhaust duct (23) extends to the outside of the upper chamber and is connected to the dust collector (25); and an exhaust valve (24) is arranged at one end of the exhaust duct (23) extending to the upper chamber.

8. A pharmaceutical continuous granulation and drying integrated machine as claimed in claim 7, characterized in that: A back-blowing air bag (10) is arranged on the top of the fluidizing chamber (12), and the back-blowing air bag (10) back-blows the plurality of filter components (9) through the upper chamber.

9. The continuous granulation and drying integrated machine for pharmaceutical use according to claim 1, characterized in that: The drop pipe is provided with a drop valve (15) and a granulator (16) in sequence from top to bottom. The granulator (16) is located at the lower end of the drop pipe. A material receiving bucket (17) is provided below the granulator (16).

10. A pharmaceutical continuous granulation and drying integrated machine as claimed in claim 9, characterized in that: The blanking pipe is provided with a temperature detector (13) and a moisture detector (14) in sequence from top to bottom, and the temperature detector (13) and the moisture detector (14) are both located above the blanking valve (15).

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