A centrifuge that automatically makes the centrifuge cup vertical

Abstract

The present invention discloses a centrifuge for automatically achieving the verticality of centrifuge cups, which includes a plurality of centrifuge cups arranged on a centrifuge turntable; a magnetic structure, which is a thin sheet structure and fixed at the bottom of each centrifuge cup; and further includes a magnetic attraction structure, which is provided with one and arranged inside the centrifuge. The magnetic attraction force of the magnetic attraction structure attracts the magnetic structure to perform a magnetic attraction action, and at the same time drives the centrifuge cup to rotate. Finally, the movement stop state of the centrifuge cup is the vertical state of the centrifuge cup; the centrifuge turntable rotates to drive the centrifuge cup to pass through the magnetic attraction structure and perform a magnetic attraction action. After rotating 360°, each centrifuge cup reaches the vertical state. In addition, a magnet induction structure that can only sense the magnetic structure on the centrifuge cup in the vertical state is provided to monitor whether the centrifuge cup is in the vertical state; after the centrifuge cup is in the vertical state through the cooperation of the magnetic structure, the magnetic attraction structure and the magnet induction structure, it then enters the next automated exosome enrichment stage.

Description

Technical Field

[0001] The present invention belongs to the field of centrifuges, and particularly relates to the technical field of automatically placing various centrifuge tubes in a vertical state into a centrifuge for centrifugation or taking them out of the centrifuge during the automated processing of exosomes. Specifically, it is an automated centrifuge that can achieve the vertical state of centrifuge cups. Background Art

[0002] The enrichment of blood-derived neurogenic exosomes is a cumbersome process that requires a lot of manpower and is prone to operational errors due to improper operation. Therefore, automated exosome enrichment devices are needed. Existing technologies such as 202110247374.3, an automated device for effectively enriching neurogenic exosomes in blood, 202210874984.0, an exosome enrichment system, and 202410109881.4, a device for enriching blood-derived neurogenic exosomes, have disclosed automated enrichment devices. It is actually a process of gradual iteration, and when implemented specifically, it faces not only overall problems but also specific problems of each structure.

[0003] Because the automated exosome device rotates in an open-lid operating state and selects to place the centrifuge tube in a vertical state into the centrifuge or take it out of the centrifuge during the process to ensure the feasibility of the automated operation process, but how to maintain the centrifuge tube in the centrifuge in a vertical state all the time is a key technical problem to be solved. 202410730340.3, a centrifuge, discloses that by limiting the rotor (centrifuge cup) in a limiting groove to maintain a safe and effective centrifugal inclination angle during centrifugation, and by setting a heavier part at the bottom of the rotor to make the center of the rotor lower than the axis of rotation, it ensures that the axis of rotation maintains a vertical state in the stopped state; however, although this method of increasing the weight at the bottom of the rotor can achieve a vertical state after centrifugation, due to the weight of the rotor, the centrifugal force increases a lot, increasing the centrifugation workload, and then causing the motor of a small centrifuge to be unable to meet the centrifugal force requirement, and ultimately resulting in the enlargement of the entire product. Therefore, a technical solution is needed that can ensure the centrifuge cup can maintain a vertical state while maintaining a relatively small centrifugal force provided by the centrifuge motor.

[0004] The present invention provides an automated centrifuge that can achieve the vertical state of centrifuge cups. Summary of the Invention

[0005] In view of the existing technology 202410730340.3, a centrifuge has the problem that due to the increase in the weight of the centrifuge cup, the small centrifuge motor cannot achieve the effective centrifugal force when enriching exosomes from blood sources, resulting in poor enrichment effect. If a centrifuge with a larger motor is used, the entire exosome device will occupy a much larger space, which is not in line with the current technical route of miniaturizing the exosome enrichment device as much as possible. Therefore, it is urgent to find a new technical solution that can maintain the centrifuge cup in a vertical state during the process of taking and placing the centrifuge tube without increasing or increasing very little the weight of the centrifuge cup.

[0006] The present invention selects a lighter centrifuge cup. Except for the technical features related to maintaining the vertical state problem, other aspects are basically the same as those of the centrifuge in 202410730340.3. Specifically, a thin-sheet magnetic structure is provided at the bottom of each centrifuge cup. The bottom plane of the thin-sheet magnetic structure is perpendicular to the longitudinal axis of the centrifuge cup. A magnetic attracting structure is provided at the bottom of the centrifuge. When a single centrifuge cup rotates to the position of the magnetic attracting structure, the suction force of the magnetic attracting structure controls the thin-sheet structure to move closer to the magnetic attracting structure, ensuring that in the final stop state, the magnetic attracting structure is arranged directly below the thin-sheet magnetic structure, and the thin-sheet magnetic structure drives the centrifuge cup to maintain a vertical state. Such a setting can ensure that the magnetic attracting structure can attract the thin-sheet magnetic structure to a vertical state. However, because the magnetic structure is a thin-sheet structure, its impact on the weight of the centrifuge cup is small, so a relatively small centrifuge can meet the requirements for centrifugal force during exosome enrichment.

[0007] Specifically: An automated centrifuge for achieving the vertical state of the centrifuge cup, which includes

[0008] Centrifuge cups, which can rotate from the vertical state in a direction away from the center of the centrifuge. A plurality of centrifuge cups are arranged on a centrifuge turntable, and centrifuge tubes are arranged inside the centrifuge cups;

[0009] Magnetic structures, which are thin-sheet structures, and a magnetic structure is fixedly arranged at the bottom of each centrifuge cup;

[0010] Magnetic attracting structure, there is one, and it is arranged inside the centrifuge. The magnetic attracting force of the magnetic attracting structure attracts the magnetic structure to perform a magnetic attracting action of approaching the magnetic attracting structure, and at the same time drives the centrifuge cup fixedly connected to the magnetic structure to rotate. Finally, the motion stop state of the centrifuge cup is the vertical state of the centrifuge cup, and the magnetic attracting structure is not arranged on the centrifuge turntable;

[0011] The rotation of the centrifuge turntable drives different centrifuge cups to pass by the magnetic attracting structure. The magnetic attracting structure attracts the magnetic structures at the bottom of each centrifuge cup to perform a magnetic attracting action, so that each centrifuge cup passing by the magnetic attracting structure completes the magnetic attracting action to reach the vertical state. After the centrifuge turntable rotates 360°, each centrifuge cup is maintained in the vertical state.

[0012] Further, when the centrifuge cup is in the vertical adjustment state, control the centrifuge turntable to maintain a rotation speed of less than 60° per second, or pause for 0.5 - 1 s when each centrifuge cup rotates above the corresponding position of the magnetic attraction structure, so as to ensure sufficient time to pull the centrifuge cup upright.

[0013] Further, a verification structure for whether the centrifuge cup is in the vertical state is also set to avoid the influence of the non-vertical state caused by incomplete magnetic attraction on subsequent operations; specifically, a magnetic induction structure is set inside the centrifuge, which can only sense the magnetic structure in the vertical state of the centrifuge cup. When the centrifuge cup rotates to the induction area of the magnetic induction structure and the centrifuge cup is in the vertical state, the magnetic induction structure senses the magnetic structure, otherwise it cannot sense the magnetic structure, proving that the centrifuge cup is not in the vertical state. By setting the magnetic induction structure, it is very effective to monitor whether the centrifuge cup is in the vertical state after the magnetic attraction action through the magnetic structure, and avoid the non-vertical state caused by insufficient magnetic attraction or the failure of the centrifuge cup itself from entering the next process stage and affecting the operation of the equipment.

[0014] Further, when the centrifuge cup rotates to the induction area of the magnetic induction structure but the centrifuge cup is not in the vertical state, the magnetic induction structure cannot sense the magnetic structure, then control the centrifuge turntable to rotate back to the position where the magnetic attraction structure is located to perform the magnetic attraction action again, so that the centrifuge cup is in the vertical state, and then rotate to the position of the magnetic induction structure again; or, label each centrifuge cup, record the label of the centrifuge cup that does not sense the magnetic structure. After rotating 360° to complete the induction of all centrifuge cups, according to the recorded label of the centrifuge cup that is not sensed, perform the magnetic attraction action again to make the centrifuge cup in the vertical state again, and then verify whether it is in the vertical state through the magnetic induction structure.

[0015] Further, when the magnetic structure at the bottom of the centrifuge cup cannot be sensed for the second time, an alarm signal is sent, the operation is stopped, and the corresponding centrifuge cup that cannot sense the magnetic structure is inspected to ensure that the centrifuge cup has a normal structure.

[0016] Further, a centrifuge cover is provided on the centrifuge, and an operation port for the operation instrument to enter the centrifuge is provided on the cover. The magnetic attraction structure is arranged at the position of the centrifuge where the operation port is located. The purpose of this setting is to perform the taking and placing actions of the centrifuge tube under the magnetic attraction of the magnetic attraction structure, so that the centrifuge cup maintains a more stable vertical state and ensures the stability of the taking and placing operations.

[0017] Further, rotate the centrifuge turntable in the clockwise or counterclockwise direction, and the magnetic induction structure is arranged at the position after the rotation direction of the magnetic attraction structure, and the interval angle between the two is a multiple of the interval angle between every two centrifuge cups.

[0018] Further, the magnet induction structures are arranged 180° apart. The purpose of this arrangement is to separate the two structures to facilitate the arrangement of each structure without mutual interference.

[0019] Further, the magnetic structure is a magnetic sheet attached to the bottom of the centrifuge cup, and the magnetic attraction structure is an electromagnetic chuck. When the magnetic structure enters above the electromagnetic chuck, power is supplied to perform the magnetic attraction action. After the magnetic attraction action is completed, the power is cut off. By this way of intermittent power on and off, it can be avoided that when the magnetic attraction action is not required, unnecessary magnetic attraction operations may cause the risk that the centrifuge cup in the vertical state is attracted and tilted again.

[0020] Further, the inner bottom of the centrifuge cup is set as a plane, and the magnetic sheet is attached to the plane of the inner bottom of the centrifuge cup. This setting can effectively avoid the risk caused by the separation of the magnetic sheet from the centrifuge cup due to the long-term centrifugal force during centrifugation.

[0021] Further, the magnet induction structure is a Hall sensor. This setting is a common structure for monitoring the magnetic structure, but it is significantly innovative to complete the adjustment of the vertical state of the centrifuge cup and the monitoring of whether it is in the vertical state through the cooperation of the Hall sensor, the patch, and the electromagnetic chuck.

[0022] Advantages of the present invention

[0023] By setting a magnetic attraction structure on the non-centrifugal turntable to cooperate with the magnetic structure in each centrifuge cup to perform the magnetic attraction action, each centrifuge cup can reach the vertical state. The whole process can be realized only by rotating the centrifugal turntable 360°. Moreover, since the magnetic attraction structure is not set on the centrifugal turntable, the overall weight of the centrifugal turntable during the centrifugation action increases very little, and a very small centrifugal motor can meet the centrifugal force required for exosome enrichment, meeting the miniaturization requirements of the whole exosome enrichment device.

[0024] By setting a magnet induction structure to verify whether the centrifuge cup is in the vertical state and cooperating with the magnetic attraction structure, it can further ensure that the centrifuge cup is in the vertical state, avoiding the subsequent operation risks in the non-vertical state caused by the insufficient magnetic attraction action of the magnetic attraction structure or the problems of the centrifuge cup itself.

[0025] By rotating the centrifugal turntable 360° respectively at the positions of the magnetic attraction structure and the magnet induction structure for two rounds, it can further ensure that the centrifuge cup is in the vertical state, and the whole program setting is simple by the rotation method of two rounds of 360°.

[0026] Through the setting of alarming when the magnetic structure cannot be sensed continuously for 2 times, it can ensure the timely maintenance of the equipment, avoid more failure risks of the whole enrichment device due to the failure to detect problems in time, and also ensure the accuracy of the exosome enrichment amount.

[0027] By arranging the magnetic structure at the bottom inside the centrifuge cup, the risk of equipment failure caused by the separation of the magnetic structure from the centrifuge cup under the action of strong centrifugal force can be avoided. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 It is a schematic longitudinal sectional structure diagram of the whole centrifuge of the present invention;

[0029] Figure 2 It is a schematic enlarged partial structure diagram of part A in the whole centrifuge of the present invention;

[0030] Figure 3 It is a schematic enlarged partial structure diagram of part B in the whole centrifuge of the present invention;

[0031] Figure 4 It is a schematic structure diagram of the whole lidless centrifuge of the present invention;

[0032] Figure 5 It is a schematic structure diagram of the whole centrifuge with a lid of the present invention;

[0033] DESCRIPTION OF THE MAIN REFERENCE NUMERALS

[0034] 1. Centrifugal turntable; 11. Setting hole; 111. Pressing block; 12. Centrifuge cup; 2. Magnetic structure; 3. Magnetic attraction structure; 4. Magnet induction structure; 5. Centrifuge lid; 51. Operation port; 6. Centrifuge outer cabin; 61. Centrifugal motor; 7. Centrifuge tube. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0035] An automated centrifuge for realizing the verticality of the centrifuge cup 12 includes a centrifuge cup 12 that can rotate from a vertical state in a direction away from the center of the centrifuge. A plurality of centrifuge cups 12 are arranged on the centrifugal turntable 1, and centrifuge tubes 7 are arranged inside the centrifuge cups 12; a magnetic structure 2, which is a thin plate structure, and one magnetic structure 2 is fixed at the bottom of each centrifuge cup 12;

[0036] It further includes a magnetic attraction structure 3, which is provided one and is arranged inside the centrifuge. The magnetic attraction force of the magnetic attraction structure 3 attracts the magnetic structure 2 to perform a magnetic attraction action of approaching the magnetic attraction structure 3, and at the same time drives the centrifuge cup 12 fixedly connected to the magnetic structure 2 to rotate. Finally, the motion stop state of the centrifuge cup 12 is the vertical state of the centrifuge cup 12, and the magnetic attraction structure 3 is not arranged on the centrifugal turntable 1; the rotation of the centrifugal turntable 1 drives different centrifuge cups 12 to pass by the magnetic attraction structure 3, and the magnetic attraction structure 3 attracts the magnetic structure 2 at the bottom of each centrifuge cup 12 to perform a magnetic attraction action, so that each centrifuge cup 12 passing by the magnetic attraction structure 3 completes the magnetic attraction action and reaches the vertical state. After the centrifugal turntable 1 rotates 360°, each centrifuge cup 12 is maintained in the vertical state.

[0037] More preferably, when the centrifuge cup 12 is in the vertical adjustment state, the rotation speed of the centrifuge turntable 1 is controlled to be less than 60° per second, or when each centrifuge cup 12 rotates above the corresponding position of the magnetic attraction structure 3, it pauses for 0.5 - 1 s to ensure sufficient time to pull the centrifuge cup 12 upright.

[0038] More preferably, a magnetic induction structure 4 is provided inside the centrifuge. It can only sense the magnetic structure 2 when the centrifuge cup 12 is in the vertical state. When the centrifuge cup 12 rotates into the sensing area of the magnetic induction structure 4 and the centrifuge cup 12 is in the vertical state, the magnetic induction structure 4 senses the magnetic structure 2, and the centrifuge turntable 1 rotates to make the next centrifuge cup 12 enter the sensing area of the magnetic induction structure 4 to verify whether the centrifuge cup 12 is in the vertical state; the verification is carried out in sequence until all centrifuge cups 12 are verified to be in the vertical state, and then the next operation stage is entered.

[0039] More preferably, when the centrifuge cup 12 rotates into the sensing area of the magnetic induction structure 4 but the centrifuge cup 12 is not in the vertical state, the magnetic induction structure 4 cannot sense the magnetic structure 2, then the centrifuge turntable 1 is controlled to rotate back to the position of the magnetic attraction structure 3 to perform the magnetic attraction action again to make the centrifuge cup 12 in the vertical state, and then it rotates to the position of the magnetic induction structure 4 again; or, each centrifuge cup 12 is numbered, and the numbers of the centrifuge cups 12 that do not sense the magnetic structure 2 are recorded. After the induction of all centrifuge cups 12 is completed after rotating 360°, according to the recorded numbers of the centrifuge cups 12 that are not sensed, the magnetic attraction action is performed again to make the centrifuge cup 12 in the vertical state again, and then the verification of whether it is in the vertical state is carried out through the magnetic induction structure 4.

[0040] More preferably, when the magnetic structure 2 at the bottom of the centrifuge cup 12 cannot be sensed for the second time, an alarm signal is issued, the operation is stopped, and the corresponding centrifuge cup 12 that cannot sense the magnetic structure 2 is inspected to ensure that the centrifuge cup 12 has a normal structure.

[0041] More preferably, all the centrifuge cups 12 are numbered, and the centrifuge cup 12 numbered one is controlled to be positioned above the magnetic attraction structure 3. Rotate 360° in the program direction, and perform the magnetic attraction action on each centrifuge cup 12 on the centrifuge turntable 1 in sequence, so that the centrifuge cup 12 is in a vertical state. During the rotation, when the first centrifuge cup completes the magnetic attraction action and enters the induction area of the magnetic induction structure 4, trigger the induction action and rotate 360° according to the program; complete the verification of whether all the centrifuge cups 12 after the magnetic attraction action are in a vertical state. During the process, record the numbers of the centrifuge cups 12 that are not sensed to be in a vertical state. After completing the first round of 360° verification; rotate the recorded centrifuge cups 12 that are not sensed to be in a vertical state to the position above the magnetic attraction structure 3 again in sequence to perform the magnetic attraction action again. After the magnetic attraction action, rotate to the induction area of the magnetic induction structure 4 again, and complete the second round of 360° rotation of the magnetic attraction action on the magnetic induction structure 4. Finally, control the centrifuge cup 12 numbered one to be positioned above the magnetic attraction structure 3 and turn on the magnetic attraction structure 3. After the above two rounds of magnetic attraction and verification of whether it is in a vertical state, all the centrifuge cups 12 are in a vertical state, and starting from the centrifuge cup 12 numbered one, start the operation of taking out or putting in the centrifuge tube 7 in the next stage. If there are still centrifuge cups 12 that are not sensed to be in a vertical state after two rounds of 360° rotation, stop for maintenance. Through two rounds of 360° rotation, it is very convenient to record and operate, and the entire program runs very smoothly.

[0042] More preferably, a centrifuge cover 5 is provided on the centrifuge, and an operation port 51 for the operation instrument to enter the centrifuge is provided on the cover. The magnetic attraction structure 3 is arranged at the position of the centrifuge where the operation port 51 is located. The purpose of this arrangement is to perform the taking and placing actions of the centrifuge tube 7 under the magnetic attraction of the magnetic attraction structure 3, so that the centrifuge cup 12 maintains a more stable vertical state and ensures the stability of the taking and placing operations.

[0043] More preferably, the centrifuge turntable 1 is rotated in the clockwise or counterclockwise direction, and the magnetic induction structure 4 is arranged at the position after the rotation direction of the magnetic attraction structure 3, and the interval angle between the two is a multiple of the interval angle between every two centrifuge cups 12.

[0044] More preferably, the magnetic induction structures 4 are arranged at an interval of 180°. The purpose of this arrangement is to separate the two structures to facilitate the arrangement of each structure without mutual interference.

[0045] A more preferred embodiment is that the magnetic structure 2 is a magnetic sheet attached to the bottom of the centrifuge cup 12, and the magnetic attraction structure 3 is an electromagnetic chuck. When the magnetic structure 2 enters above the electromagnetic chuck, power is supplied to perform the magnetic attraction action, and the power is cut off after the magnetic attraction action ends. By this way of intermittently supplying and cutting off power, it is possible to avoid the risk that when the magnetic attraction action is not required, unnecessary magnetic attraction operations may occur, causing the centrifuge cup 12 in the vertical state to be attracted and tilted again.

[0046] A more preferred embodiment is that the inner bottom of the centrifuge cup 12 is set to be flat, and the magnetic sheet is attached to the flat inner bottom of the centrifuge cup 12. This setting can effectively avoid the risk caused by the separation of the magnetic sheet from the centrifuge cup 12 due to the long-term centrifugal force during centrifugation.

[0047] A more preferred embodiment is that the magnet induction structure 4 is a Hall sensor. This setting is a common structure for monitoring the magnetic structure 2, but it is significantly innovative to complete the adjustment of the vertical state of the centrifuge cup 12 and the monitoring of whether it is in the vertical state through the cooperation of the Hall sensor, the patch, and the electromagnetic chuck.

[0048] A more preferred embodiment is that the bottom of the centrifugal turntable 1 is a closed structure, and the bottom is a thin-bottom structure. The thin-bottom structure will not interfere with the magnetic attraction force and induction force of the electromagnetic chuck and the Hall sensor on the magnetic sheet. The setting of the closed centrifugal turntable 1 can effectively avoid the formation of a wind channel in the centrifugation chamber, resulting in a large centrifugation noise.

[0049] A more preferred embodiment is that the outside of the centrifugal turntable 1 is the outer cabin 6 of the centrifuge. An electric centrifugal motor 61 is arranged in the middle of the outer cabin 6 of the centrifuge. The magnetic attraction structure 3 and the Hall sensor are arranged at the corresponding positions on the bottom of the outer cabin 6 of the centrifuge. By this setting, the effective rotation of the centrifugal turntable 1 can be ensured. Neither the magnetic attraction structure 3 nor the Hall sensor is arranged on the centrifugal turntable 1, which can minimize the weight of the centrifugal turntable 1. It will not increase the weight of the centrifugal turntable 1 due to adding a structure to ensure the vertical state of the centrifuge cup 12. In order to achieve the vertical state of the centrifuge cup 12, only a little weight of the magnetic sheet is added to the centrifugal turntable 1, and this weight is very small and can be ignored.

[0050] A more preferred embodiment is that a plurality of setting holes 11 for the centrifuge cups 12 are arranged on the centrifugal turntable 1. The setting holes 11 are high at the edge and low in the middle, and are oval when viewed from above. The width of the oval is adapted to the outer diameter of the centrifuge cup 12. This setting enables the centrifuge cup 12 to rotate only along the long side direction of the oval, and all magnetic attraction actions only control the rotation of the centrifuge cup 12 in the long side direction.

[0051] A more preferred embodiment is that a rotating shaft is provided on the centrifuge cup 12, a shaft hole adapted to the rotating shaft is provided on the setting hole 11, and a pressing block 111 for restricting the rotating shaft of the centrifuge cup 12 within the shaft hole is provided on the setting hole 11. By providing the pressing block 111, the centrifuge cup 12 can be well stabilized at the position of the setting hole 11.

[0052] During use, when it is necessary to transfer the centrifuge tube 7 into the centrifuge cup 12, the centrifuge turntable 1 is rotated at a slower speed. The centrifuge cup 12 labeled one stops rotating when it reaches the magnetic attraction structure 3. The magnetic attraction structure 3 is started to perform a magnetic attraction action on the centrifuge cup 12 to make the centrifuge cup 12 reach a vertical state. Then the magnetic attraction structure 3 is stopped, and the centrifuge turntable 1 is rotated to transport the next centrifuge cup 12 to the position of the magnetic attraction structure 3, repeating the previous operation until after rotating 360°, a round of magnetic attraction operation is completed. Or a relatively low speed rotation can be maintained, and the low speed rotation process does not affect the progress of the magnetic attraction action. During the process, when the centrifuge cup 12 labeled one enters the corresponding area of the magnetic induction structure 4 and completes the induction action, it is recorded whether the corresponding centrifuge cup 12 is in a vertical state. After rotating 360°, after completing a round of verification of whether it is in a vertical state, when all the centrifuge cups 12 are in a vertical state, the centrifuge cup 12 labeled one is moved to the corresponding position of the magnetic attraction structure 3, and the magnetic attraction structure 3 is turned on. In the working state of the magnetic attraction structure 3, the centrifuge tube 7 is sent into the centrifuge cup 12 through the operation port 51 on the centrifuge cover. Then the magnetic attraction structure 3 is stopped, and the centrifuge turntable 1 is rotated to send the next centrifuge cup 12 to the position of the magnetic attraction structure 3, repeating the previous operation until after rotating 360 degrees, the centrifuge tubes 7 are all placed in all the centrifuge cups 12.

[0053] Similarly, when it is necessary to transfer the centrifuge tube 7 out of the centrifuge cup 12, first, the operation of making all the centrifuge cups 12 in a vertical state is also completed according to the above actions. After completion, starting from the centrifuge cup 12 labeled one, all the centrifuge tubes 7 are moved out of the centrifuge cup 12.

[0054] The technical solutions in the embodiments of the present invention are clearly and completely described above through specific specific embodiments. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments. Without conflict, the above embodiments and the features in the embodiments can be combined with each other. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present invention.

Claims

1. An automated centrifuge for achieving the verticality of centrifuge cups, comprising Centrifuge cups that can rotate from the vertical state in a direction away from the center of the centrifuge. A plurality of centrifuge cups are arranged on a centrifuge turntable, and centrifuge tubes are arranged inside the centrifuge cups. It is characterized in that A magnetic structure, which is a thin sheet structure, and a magnetic structure is fixed at the bottom of each centrifuge cup A magnetic attraction structure, which is provided one and is arranged inside the centrifuge. The magnetic attraction force of the magnetic attraction structure attracts the magnetic structure to perform a magnetic attraction action of approaching the magnetic attraction structure, and at the same time drives the centrifuge cup fixedly connected to the magnetic structure to rotate. Finally, the motion stop state of the centrifuge cup is the vertical state of the centrifuge cup, and the magnetic attraction structure is not arranged on the centrifuge turntable The rotation of the centrifuge turntable drives different centrifuge cups to pass through the magnetic attraction structure. The magnetic attraction structure attracts the magnetic structures at the bottoms of each centrifuge cup to perform magnetic attraction actions, so that each centrifuge cup passing through the magnetic attraction structure completes the magnetic attraction action to reach the vertical state. After the centrifuge turntable rotates 360°, each centrifuge cup is maintained in the vertical state A magnetic induction structure is arranged inside the centrifuge for monitoring whether the centrifuge cup is in the vertical state by detecting whether the magnetic structure can be detected It can only detect the magnetic structure in the vertical state of the centrifuge cup. When the centrifuge cup rotates to the induction area of the magnetic induction structure and the centrifuge cup is in the vertical state, the magnetic induction structure detects the magnetic structure; otherwise, it cannot detect the magnetic structure, indicating that the centrifuge cup is not in the vertical state When the centrifuge cup rotates to the induction area of the magnetic induction structure but the centrifuge cup is not in the vertical state, the magnetic induction structure cannot detect the magnetic structure. Then, control the centrifuge turntable to rotate back to the position where the magnetic attraction structure is located to perform the magnetic attraction action again, so that the centrifuge cup is in the vertical state, and then rotate to the position of the magnetic induction structure again; or, label each centrifuge cup, record the label of the centrifuge cup where the magnetic structure is not detected. After rotating 360° to complete the induction of all centrifuge cups, according to the recorded label of the centrifuge cup not detected, perform the magnetic attraction action again to make the centrifuge cup in the vertical state again, and then verify whether it is in the vertical state through the magnetic induction structure 2. The centrifuge according to claim 1, wherein When adjusting the vertical state of the centrifuge cup, control the centrifuge turntable to maintain a rotation speed of less than 60° per second, or pause for 0.5 - 1 s when each centrifuge cup rotates above the corresponding position of the magnetic attraction structure 3. The centrifuge according to claim 1, characterized in that, When the magnetic structure at the bottom of the centrifuge cup cannot be detected for the second time, an alarm signal is issued and the operation is stopped 4. The centrifuge according to claim 1, characterized in that Label all the centrifuge cups. Control the centrifuge cup numbered 1 to be above the magnetic attraction structure. Rotate 360° in the program direction, and perform magnetic attraction actions on each centrifuge cup on the centrifuge turntable in turn, so that the centrifuge cups are in a vertical state. When the first centrifuge cup completes the magnetic attraction action and enters the induction area of the magnetic induction structure, trigger the induction action and rotate 360° according to the program. Verify whether all the centrifuge cups after the magnetic attraction action are in a vertical state. During the process, record the numbers of the centrifuge cups that are not sensed to be in a vertical state. After completing the first round of 360° verification, rotate the recorded centrifuge cups that are not sensed to be in a vertical state above the magnetic attraction structure again in turn to perform magnetic attraction actions. After the magnetic attraction action, rotate them to the induction area of the magnetic induction structure again, and complete the second round of 360° rotation of the magnetic attraction action on the magnetic induction structure. Finally, control the centrifuge cup numbered 1 to be above the magnetic attraction structure and turn on the magnetic attraction structure.

5. The centrifuge according to claim 1, wherein A centrifuge cover is provided on the centrifuge. An operation port for the operation instrument to enter the centrifuge is provided on the cover. The magnetic attraction structure is provided at the position of the centrifuge where the operation port is located.

6. The centrifuge according to claim 1, wherein, Rotate the centrifuge turntable in the clockwise or counterclockwise direction. The magnetic induction structure is provided at the position after the rotation direction of the magnetic attraction structure, and the interval angle between the two is a multiple of the interval angle between every two centrifuge cups.

7. The centrifuge according to claim 6, characterized in that, The magnetic induction structures are arranged at an interval of 180°.

8. The centrifuge according to claim 1, characterized in that, The magnetic structure is a magnetic sheet attached to the bottom of the centrifuge cup. The magnetic attraction structure is an electromagnetic chuck. When the magnetic structure enters above the electromagnetic chuck, power on for magnetic attraction action and power off after the magnetic attraction action ends. The magnetic induction structure is a Hall sensor.

9. The centrifuge according to claim 8, characterized in that, The inner bottom of the centrifuge cup is set as a plane, and the magnetic sheet is attached to the inner bottom plane of the centrifuge cup.

10. The centrifuge according to claim 1, characterized in that, The bottom of the centrifuge turntable is a closed structure, and the bottom is a thin-bottom structure. The thin-bottom structure will not interfere with the magnetic attraction force and induction force of the electromagnetic chuck and the Hall sensor on the magnetic sheet.

11. The centrifuge according to claim 10, characterized in that, The outer side of the centrifuge turntable is the outer cabin of the centrifuge. A centrifuge motor is provided in the middle of the outer cabin of the centrifuge. The magnetic attraction structure and the Hall sensor are provided at the corresponding positions on the bottom of the outer cabin of the centrifuge.

12. The centrifuge according to claim 10, characterized in that, A plurality of setting holes for centrifuge cups are provided on the centrifuge turntable. The setting holes are high at the edge and low in the middle. When viewed from above, they are oval. The width of the oval is adapted to the outer diameter of the centrifuge cup.

13. The centrifuge according to claim 10, characterized in that, A rotating shaft is provided on the centrifuge cup. A shaft hole adapted to the rotating shaft is provided on the setting hole. A pressing block for restricting the rotating shaft of the centrifuge cup in the shaft hole is provided on the setting hole.

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