High-barrier biological medicine consumable and preparation method thereof

Abstract

The invention discloses a high-barrier biological medicine consumable and a preparation method thereof. The high-barrier biological medicine consumable comprises a polymer, an antibacterial agent, resin, a cross-linking agent, a coupling agent and a dispersing agent, the high-barrier biomedical consumable comprises, by weight, 60-70 parts of a polymer, 1-3 parts of an antibacterial agent, 10-20 parts of resin, 1-3 parts of a cross-linking agent, 0.5-1 part of a coupling agent and 0.3-0.5 part of a dispersing agent, the polymer and the resin are combined, the strength and barrier property of the biomedical consumable are improved, the antibacterial agent added with a stabilizer and a pH regulator is used, and the high-barrier biomedical consumable is prepared. Further, the antibacterial stability of the biological medicine consumables is improved, and the medicine is not influenced.

Description

Technical Field

[0001] The present invention relates to the technical field of biomedical consumables, and in particular to a high-barrier biomedical consumable and a preparation method thereof. Background Art

[0002] High-barrier biomedical consumables refer to biomedical consumables with high barrier capabilities, designed to prevent interaction and contamination with biological system substances. These consumables are usually used in the biomedical field. With the improvement of living standards and the acceleration of aging, the frequency of residents' use of medical consumables has continued to increase, driving the rapid development of the medical consumables industry.

[0003] Existing high-barrier biomedical consumables and preparation methods thereof use a single material or a combination to prepare high-barrier biomedical consumables. However, with this method, after the finished products are prepared, they need to be transported using pressure-resistant boxes or barrier plates, which results in a small transportation quantity, increased transportation costs, and some finished products may be crushed and unusable. Summary of the invention

[0004] The purpose of the present invention is to solve at least one of the technical problems existing in the prior art, and to provide a high-barrier biomedical consumable and a preparation method thereof, by combining a polymer with a resin to increase the strength and barrier properties of the biomedical consumable, and by using an antibacterial agent with added stabilizers and pH regulators to increase the antibacterial stability of the biomedical consumable without affecting the drugs.

[0005] The present invention also provides the above-mentioned high-barrier biomedical consumables, including: polymer, antibacterial agent, resin, cross-linking agent, coupling agent, dispersant; the weight ratio of the high-barrier biomedical consumables is: 60-70 parts of polymer, 1-3 parts of antibacterial agent, 10-20 parts of resin, 1-3 parts of cross-linking agent, 0.5-1 part of coupling agent, and 0.3-0.5 part of dispersant.

[0006] According to a high-barrier biomedical consumable material provided by the present invention, the polymer is specifically one or more of polyethylene, medical polyvinyl chloride, polypropylene, and polycarbonate.

[0007] According to a high-barrier biomedical consumable provided by the present invention, the antibacterial agent includes: phenolic substances, metal ions, stabilizers, and pH regulators.

[0008] According to a high-barrier biomedical consumable material provided by the present invention, the resin is specifically polypropylene resin.

[0009] According to a high-barrier biomedical consumable provided by the present invention, the cross-linking agent is specifically one of acrylic acid, vinyl aldehyde, and hydrazine cross-linking agents.

[0010] According to a high-barrier biomedical consumable provided by the present invention, the coupling agent is specifically one of an azo coupling agent, a phosphate coupling agent, and a disulfide dichloride coupling agent.

[0011] According to a high-barrier biomedical consumable provided by the present invention, the phenolic substance is specifically one of cresol and phenol.

[0012] According to a high-barrier biomedical consumable provided by the present invention, the metal ion is specifically one of silver ions and copper ions.

[0013] According to a high-barrier biomedical consumable provided by the present invention, the stabilizer is specifically one or more of eggeric acid and phosphate.

[0014] A method for preparing a high-barrier biomedical consumable material comprises the following steps:

[0015] S1. Introduce the polymer and resin into a pulverizer according to the proportion, and after working for 20-30 minutes, obtain a mixed powder;

[0016] S2, pouring the mixed powder, crosslinking agent, coupling agent and dispersant into a reactor, and obtaining a preliminary product after reaction;

[0017] S3. Immerse the preliminary product in an antibacterial agent for 2-6 hours to obtain an antibacterial product, pour the antibacterial product into an extruder, set the temperature at 200-220°C, extrude and granulate to obtain a high-barrier biomedical consumable.

[0018] Compared with the prior art, the high-barrier biomedical consumables and the preparation method thereof increase the strength of the biomedical consumables by combining polymers with resins, and increase the antibacterial stability of the biomedical consumables by using antibacterial agents with added stabilizers and pH regulators, without affecting drugs. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The present invention is further described below in conjunction with the accompanying drawings and embodiments;

[0020] Figure 1 The present invention is a flow chart of the high-barrier biomedical consumables and the preparation method thereof. DETAILED DESCRIPTION

[0021] This section will describe in detail the specific embodiments of the present invention. The preferred embodiments of the present invention are shown in the accompanying drawings. The purpose of the accompanying drawings is to supplement the description of the text part of the specification with graphics, so that people can intuitively and vividly understand each technical feature and the overall technical solution of the present invention, but it cannot be understood as a limitation on the scope of protection of the present invention.

[0022] Example 1

[0023] Reference Figure 1 The embodiment of the present invention provides a high-barrier biomedical consumable and a preparation method thereof, which includes: a polymer, an antibacterial agent, a resin, a cross-linking agent, a coupling agent, and a dispersant; the weight ratio of the high-barrier biomedical consumable is: 60 parts of polymer, 1 part of antibacterial agent, 10 parts of resin, 1 part of cross-linking agent, 0.5 part of coupling agent, and 0.3 part of dispersant.

[0024] The polymer is specifically one or more of polyethylene, medical polyvinyl chloride, polypropylene, and polycarbonate.

[0025] Antimicrobial agents include: phenolic substances, metal ions, stabilizers, and pH adjusters.

[0026] The resin is specifically polypropylene resin.

[0027] The crosslinking agent is specifically one of acrylic acid, vinyl aldehyde, and hydrazine crosslinking agents.

[0028] The coupling agent is specifically one of an azo coupling agent, a phosphate coupling agent, and a disulfide dichloride coupling agent.

[0029] The phenolic substance is specifically one of cresol and orthophenol.

[0030] The metal ion is specifically one of a silver ion and a copper ion.

[0031] The stabilizer is specifically one or more of eggeric acid and phosphate.

[0032] The method for preparing the high barrier biomedical consumables of this embodiment comprises the following steps:

[0033] S1. Introduce the polymer and resin into a pulverizer according to the proportion, and after working for 20-30 minutes, obtain a mixed powder;

[0034] S2, pouring the mixed powder, crosslinking agent, coupling agent and dispersant into a reactor, and obtaining a preliminary product after reaction;

[0035] S3. Immerse the preliminary product in an antibacterial agent for 2-6 hours to obtain an antibacterial product, pour the antibacterial product into an extruder, set the temperature at 200-220°C, extrude and granulate to obtain a high-barrier biomedical consumable.

[0036] Example 2

[0037] The weight ratio of the biomedical consumables is: 65 parts of polymer, 2 parts of antibacterial agent, 15 parts of resin, 2 parts of cross-linking agent, 0.75 parts of coupling agent, and 0.75 parts of dispersant. The preparation method is the same as that of Example 1.

[0038] Example 3

[0039] The weight ratio of the biomedical consumables is: 70 parts of polymer, 3 parts of antibacterial agent, 20 parts of resin, 3 parts of cross-linking agent, 1 part of coupling agent, and 0.5 parts of dispersant. The preparation method is the same as that of Example 1.

[0040] Comparative Example 1

[0041] PE material is used and extruded through an extruder to prepare biomedical consumables. PE biomedical consumables are divided into HDPE material and LDPE material.

[0042] Comparative Example 2

[0043] PET material is used and extruded through an extruder to prepare biomedical consumables.

[0044] Table 1. The test results are as follows

[0045]

[0046]

[0047] The above data were all tested five times, and the average of the maximum and minimum values ​​was taken. It can be seen that the composition used in the present invention is more pressure-resistant and has stronger tensile strength.

[0048] The embodiments of the present invention are described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the above embodiments. Various changes can be made within the knowledge scope of ordinary technicians in the technical field without departing from the purpose of the present invention.

Claims

1. A high barrier biomedical consumables, characterized in that: include: Polymers, antimicrobial agents, resins, cross-linking agents, coupling agents, dispersants; The weight ratio of the high-barrier biomedical consumables is: 60-70 parts of polymer, 1-3 parts of antibacterial agent, 10-20 parts of resin, 1-3 parts of cross-linking agent, 0.5-1 parts of coupling agent, and 0.3-0.5 parts of dispersant.

2. A high barrier biomedical consumable according to claim 1, characterized in that: The polymer is specifically one or more of polyethylene, medical polyvinyl chloride, polypropylene, and polycarbonate.

3. A high barrier biomedical consumable according to claim 1, characterized in that: The antibacterial agent comprises: phenolic substances, metal ions, stabilizers and pH regulators.

4. A high barrier biomedical consumable according to claim 1, characterized in that: The resin is specifically polypropylene resin.

5. A high barrier biomedical consumable and a preparation method thereof according to claim 1, characterized in that: The crosslinking agent is specifically one of acrylic acid, vinyl aldehyde and hydrazine crosslinking agents.

6. A high barrier biomedical consumable and a preparation method thereof according to claim 1, characterized in that: The coupling agent is specifically one of an azo coupling agent, a phosphate coupling agent, and a disulfide dichloride coupling agent.

7. A high barrier biomedical consumable and a preparation method thereof according to claim 3, characterized in that: The phenolic substance is specifically one of cresol and phenol.

8. A high barrier biomedical consumable and a preparation method thereof according to claim 3, characterized in that: The metal ion is specifically one of silver ion and copper ion.

9. A high barrier biomedical consumable and a preparation method thereof according to claim 3, characterized in that: The stabilizer is specifically one or more of eggeric acid and phosphate.

10. A method for preparing a high-barrier biomedical consumable, characterized in that: The following steps are involved: S1. Introduce the polymer and resin into a pulverizer according to the proportion, and after working for 20-30 minutes, obtain a mixed powder; S2, pouring the mixed powder, crosslinking agent, coupling agent and dispersant into a reactor, and obtaining a preliminary product after reaction; S3. Immerse the preliminary product in an antibacterial agent for 2-6 hours to obtain an antibacterial product, pour the antibacterial product into an extruder, set the temperature to 200-220°C, extrude and granulate to obtain a high-barrier biomedical consumable.

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