A composition and its application in preparing solubilizer

Abstract

The present invention relates to the fields of chemical engineering and biomedicine, and specifically discloses a composition and its use in preparing a solubilizing agent. The composition comprises the following components: oleyl alcohol polyether, hydrogenated castor oil, and polyethylene glycol; wherein the mass ratio of oleyl alcohol polyether, hydrogenated castor oil, and polyethylene glycol is 0.1-4:4-6:0.1-4. The inventors discovered in their research that the composition of the present invention, comprising oleyl alcohol polyether, hydrogenated castor oil, and polyethylene glycol, has a solubilizing effect on menthol in water, increasing the solubility of menthol in water and resulting in a higher solubility of menthol in water; therefore, the composition of the present invention has important application value as a solubilizing agent for menthol.

Description

Technical Field

[0001] The present invention relates to the technical fields of chemical industry and biomedicine, and in particular to a composition and application thereof in preparing a solubilizing agent. Background Art

[0002] Racemic menthol (DL-menthol) is also called menthol, and its chemical formula is C 10 H 20 O is a terpene organic compound extracted from the leaves and stems of mint. It acts on the skin or mucous membranes, providing a cooling and antipruritic effect. Internally, it can be used as a carminative for headaches and inflammation of the nose, pharynx, and throat. It can be used as a special additive in therapeutic cosmetics, such as floral water, and as a flavoring agent in toothpaste, perfume, beverages, and candy.

[0003] However, menthol has a low solubility in water and usually requires the addition of ethanol to increase its solubility. Providing a solubilizer for increasing the solubility of menthol in water is a key research topic for those skilled in the art. Summary of the Invention

[0004] In order to overcome at least one of the technical problems existing in the prior art, the present invention provides a composition and its use in preparing a solubilizer.

[0005] The technical solutions of the present invention are as follows:

[0006] The present invention first provides a composition comprising the following components: oleyl alcohol polyether, hydrogenated castor oil and polyethylene glycol.

[0007] The inventors discovered in their research that a composition consisting of oleyl alcohol polyether, hydrogenated castor oil, and polyethylene glycol has a solubilizing effect on menthol in water, thereby increasing the solubility of menthol in water.

[0008] Preferably, the mass ratio of oleyl alcohol polyether, hydrogenated castor oil and polyethylene glycol is 0.1-4:4-6:0.1-4.

[0009] More preferably, the mass ratio of oleyl alcohol polyether, hydrogenated castor oil and polyethylene glycol is 2-4:4-6:1-3.

[0010] More preferably, the mass ratio of oleyl alcohol polyether, hydrogenated castor oil and polyethylene glycol is 3-4:4-5:1-2.

[0011] Most preferably, the mass ratio of oleyl alcohol polyether, hydrogenated castor oil and polyethylene glycol is 3:5:2.

[0012] Further research by the inventors revealed that the mass ratio of oleyl alcohol, hydrogenated castor oil, and polyethylene glycol is crucial. Studies have shown that a composition obtained by combining oleyl alcohol, hydrogenated castor oil, and polyethylene glycol in a mass ratio of 3:5:2 is significantly more effective at solubilizing menthol in water than compositions obtained by combining oleyl alcohol, hydrogenated castor oil, and polyethylene glycol at other mass ratios.

[0013] Preferably, the oleth is oleth-20.

[0014] Preferably, the hydrogenated castor oil is PEG-40 hydrogenated castor oil.

[0015] Preferably, the polyethylene glycol is polyethylene glycol-8.

[0016] Preferably, the composition further comprises cocotrimonium chloride and sodium N-oleoyl-N-methyltaurate.

[0017] In further research, the inventors discovered that by further adding cocotrimonium chloride and sodium N-oleoyl-N-methyltaurate to a composition consisting of oleyl alcohol polyether, hydrogenated castor oil, and polyethylene glycol, the solubilization effect of the composition on menthol in water can be further significantly enhanced.

[0018] The inventors further discovered in further research that the solubilization of menthol in water by the composition consisting of oleyl alcohol polyether, hydrogenated castor oil, and polyethylene glycol can be significantly enhanced only by adding both cocotrimonium chloride and sodium N-oleoyl-N-methyltaurate. However, the addition of either cocotrimonium chloride or sodium N-oleoyl-N-methyltaurate alone does not significantly enhance the solubilization of menthol in water by the composition.

[0019] Preferably, the composition comprises oleth, hydrogenated castor oil, polyethylene glycol, cocotrimonium chloride and sodium N-oleoyl-N-methyltaurate.

[0020] More preferably, the mass ratio of oleyl alcohol polyether, hydrogenated castor oil, polyethylene glycol, cocotrimonium chloride and sodium N-oleoyl-N-methyltaurate is 2-4:4-6:1-3:1-3:2-4.

[0021] Most preferably, the mass ratio of oleth, hydrogenated castor oil, polyethylene glycol, cocotrimonium chloride and sodium N-oleoyl-N-methyltaurate is 3:5:2:2:3.

[0022] The present invention also provides an application of the composition in preparing a solubilizer.

[0023] Preferably, the solubilizer is a solubilizer for menthol.

[0024] Preferably, the menthol is DL-menthol.

[0025] Beneficial effects: The present invention provides a new composition. The inventors have found in their research that the composition of the present invention, composed of oleyl alcohol polyether, hydrogenated castor oil, and polyethylene glycol, has a solubilizing effect on menthol in water, and can increase the solubility of menthol in water, thereby making menthol have a higher solubility in water. Therefore, the composition of the present invention has important application value as a solubilizing agent for menthol. DETAILED DESCRIPTION

[0026] The present invention is further explained below with reference to specific examples, but the examples do not limit the present invention in any form.

[0027] Example 1 Preparation of solubilizer composition

[0028] The solubilizer composition is obtained by uniformly mixing oleth-20, PEG-40 hydrogenated castor oil and polyethylene glycol-8 in a mass ratio of 3:5:2.

[0029] Example 2 Preparation of solubilizer composition

[0030] The solubilizer composition is obtained by uniformly mixing oleth-20, PEG-40 hydrogenated castor oil and polyethylene glycol-8 in a mass ratio of 2:6:1.

[0031] Example 3 Preparation of solubilizer composition

[0032] The solubilizer composition is obtained by uniformly mixing oleth-20, PEG-40 hydrogenated castor oil and polyethylene glycol-8 in a mass ratio of 4:4:3.

[0033] Example 4 Preparation of solubilizer composition

[0034] The solubilizer composition is obtained by uniformly mixing oleth-20, PEG-40 hydrogenated castor oil, polyethylene glycol-8, cocotrimonium chloride and sodium N-oleoyl-N-methyltaurate in a mass ratio of 3:5:2:2:3.

[0035] Comparative Example 1 Preparation of solubilizer composition

[0036] The solubilizer composition is obtained by uniformly mixing oleth-20, PEG-40 hydrogenated castor oil, polyethylene glycol-8 and cocotrimonium chloride in a mass ratio of 3:5:2:2.

[0037] Comparative Example 2 Preparation of Solubilizer Composition

[0038] The solubilizer composition is obtained by uniformly mixing oleth-20, PEG-40 hydrogenated castor oil, polyethylene glycol-8 and sodium N-oleoyl-N-methyl taurate in a mass ratio of 3:5:2:3.

[0039] Experimental Example 1

[0040] 10 g of DL-menthol and the solubilizer composition to be tested were added to 1 L of water, followed by stirring at 60° C. for 30 minutes. The mixture was then allowed to stand at 25° C. for 24 hours, and finally centrifuged to obtain the supernatant. The DL-menthol content in the supernatant was determined. The test results are shown in Table 1.

[0041] The DL-menthol content was determined by gas chromatography; the gas chromatography method was performed with reference to the gas chromatography method described in the literature "Determination of Menthol Content in Piyanping Ointment by Gas Chromatography [J]. Xia Xinzhong, Li Wanjiang, Lu Jing, Mao Shanting, Ma Xinguo. Journal of Yangtze University. 2008, No. 3." The solubilizer compositions to be tested were the solubilizer compositions prepared in Examples 1 to 4 and Comparative Examples 1 and 2.

[0042] Table 1. Solubilizing effect of solubilizer composition on menthol

[0043] DL-Menthol Content The solubilizer composition prepared in Example 1 4.5g / L The solubilizer composition prepared in Example 2 2.6g / L Example 3 Solubilizer composition prepared 2.1g / L The solubilizer composition prepared in Example 4 8.8g / L The solubilizer composition prepared in Comparative Example 1 5.1g / L Comparative Example 2: Solubilizer composition prepared 5.9g / L

[0044] As can be seen from the experimental results in Table 1, after solubilizing DL-menthol using the solubilizer composition prepared in Example 1, the DL-menthol content in water can reach 4.5 g / L. This shows that the composition composed of oleyl alcohol polyether, hydrogenated castor oil, and polyethylene glycol has an excellent solubilizing effect on menthol in water.

[0045] As can be seen from the experimental results in Table 1, the DL-menthol content in water solubilized using the solubilizer composition prepared in Example 1 is significantly higher than the DL-menthol content in water solubilized using the solubilizer compositions prepared in Examples 2 and 3. This indicates that the mass ratio of oleyl alcohol, hydrogenated castor oil, and polyethylene glycol is crucial. Studies have shown that a composition combining oleyl alcohol, hydrogenated castor oil, and polyethylene glycol in a mass ratio of 3:5:2 is significantly more effective in solubilizing menthol in water than compositions combining oleyl alcohol, hydrogenated castor oil, and polyethylene glycol at other mass ratios.

[0046] As can be seen from the experimental results in Table 1, the DL-menthol content in water after solubilization using the solubilizer composition prepared in Example 4 is significantly higher than the DL-menthol content in water after solubilization using the solubilizer composition prepared in Example 1. This indicates that the addition of cocotrimonium chloride and sodium N-oleoyl-N-methyltaurate to the composition consisting of oleyl alcohol polyether, hydrogenated castor oil, and polyethylene glycol can further significantly enhance the solubilization effect of the composition on menthol in water.

[0047] As can be seen from the experimental results in Table 1, the DL-menthol content in water after solubilization using the solubilizer compositions prepared in Comparative Examples 1 and 2 was not significantly higher than the DL-menthol content in water after solubilization using the solubilizer composition prepared in Example 1. This indicates that the addition of both cocotrimonium chloride and sodium N-oleoyl-N-methyltaurate to the composition comprising oleyl alcohol polyether, hydrogenated castor oil, and polyethylene glycol is necessary to significantly enhance the solubilization of menthol in water. However, the addition of either cocotrimonium chloride or sodium N-oleoyl-N-methyltaurate alone does not significantly enhance the solubilization of menthol in water.

Claims

1. A composition, characterized in that Contains the following ingredients: oleyl alcohol polyether, hydrogenated castor oil and polyethylene glycol; The composition also contains coconut trimethyl ammonium chloride and sodium N-oleoyl-N-methyl taurate.

2. The composition according to claim 1, characterized in that The mass ratio of oleyl alcohol polyether, hydrogenated castor oil and polyethylene glycol is 0.1-4:4-6:0.1-4.

3. The composition according to claim 1, characterized in that The mass ratio of oleyl alcohol polyether, hydrogenated castor oil and polyethylene glycol is 2-4:4-6:1-3.

4. The composition according to claim 1, characterized in that The mass ratio of oleyl alcohol polyether, hydrogenated castor oil and polyethylene glycol is 3-4:4-5:1-2.

5. The composition according to claim 1, characterized in that The mass ratio of oleyl alcohol polyether, hydrogenated castor oil and polyethylene glycol is 3:5:

2.

6. The composition according to claim 1, characterized in that The oleth is oleth-20.

7. The composition according to claim 1, characterized in that The hydrogenated castor oil is PEG-40 hydrogenated castor oil.

8. The composition according to claim 1, characterized in that The polyethylene glycol is polyethylene glycol-8.

9. Use of the composition according to any one of claims 1 to 8 in the preparation of a solubilizer.

10. The use according to claim 9, characterized in that The solubilizer is a solubilizer for menthol.