Temperature adjusting and storing device

Abstract

The embodiment of the invention discloses a temperature regulation storage device. The temperature regulation storage device comprises a control module, a low-temperature storage module, a cooling module and a transportation module, wherein the low-temperature storage module comprises at least two low-temperature storage units; the low-temperature storage unit comprises a refrigeration compression mechanism, a storage pipe and a refrigeration pipeline, the refrigeration compression mechanism is connected with the refrigeration pipeline, and the refrigeration pipeline is connected with the storage pipe; the cooling module comprises a cooling box, a cooling sample bearing disc and a cooling mechanism, a cooling sample conveying pipe is arranged above the cooling module, a conveying hole is formed in the cooling box, the cooling box communicates with the cooling sample conveying pipe through the conveying hole, and the cooling sample bearing disc is located in the cooling box; at least one cooling sample bearing hole is formed in the cooling sample bearing disc, and each cooling sample bearing hole is used for bearing a sample; the low-temperature storage module, the cooling module and the transportation module are all in communication connection with the control module. The temperature regulation storage device can reduce the probability of sample damage.

Description

Technical Field

[0001] Embodiments of the present disclosure relate to the field of temperature regulation technology, and in particular to a temperature regulation storage device. Background Art

[0002] Sample cryogenic storage is a common operation in scientific research, medical and industrial fields. The purpose is to extend the storage time of samples and maintain their activity or stability by lowering the temperature. Currently, most methods of sample cryogenic storage are to directly store samples in a cryogenic storage room.

[0003] However, the inventors have found that when the above-mentioned sample low-temperature storage method is used to store samples at low temperatures, the following technical problems often occur: When the temperature difference between the storage temperature in the storage device and the room temperature is large, directly placing the sample in the low-temperature storage chamber will cause temperature shock to the sample. At the same time, the temperature of the sample will also affect the temperature in the storage device, thereby affecting the storage temperature environment of other samples in the storage device and causing damage to the sample.

[0004] The above information disclosed in this Background section is only for enhancement of understanding of the background of the inventive concept. Summary of the invention

[0005] The content of this disclosure is used to introduce concepts in a brief form, which will be described in detail in the detailed implementation section below. The content of this disclosure is not intended to identify the key features or essential features of the technical solution claimed for protection, nor is it intended to limit the scope of the technical solution claimed for protection.

[0006] Some embodiments of the present disclosure provide a temperature regulating storage device to solve one or more of the technical problems mentioned in the above background technology section.

[0007] Some embodiments of the present disclosure provide a temperature regulating storage device, which includes: a control module, a low-temperature storage module, a cooling module and a transportation module, wherein the low-temperature storage module includes at least two low-temperature storage units, and different low-temperature storage units are set with different storage temperatures; the low-temperature storage unit includes a refrigeration compression mechanism, a storage tube and a refrigeration pipeline, the refrigeration compression mechanism is connected to the refrigeration pipeline, the refrigeration pipeline is connected to the storage tube, and the refrigeration pipeline is used to transport refrigerant; the cooling module includes a cooling box, a cooling sample carrier and a cooling mechanism, and the upper part of the cooling module A cooling sample transmission tube is provided, a transmission hole is opened on the above-mentioned cooling box, the above-mentioned cooling box is connected with the above-mentioned cooling sample transmission tube through the transmission hole, the above-mentioned cooling sample carrying plate is located inside the above-mentioned cooling box, and at least one cooling sample carrying hole is provided on the above-mentioned cooling sample carrying plate, each cooling sample carrying hole is used to carry a sample, and the above-mentioned cooling mechanism is used to pre-cool each sample carried on the above-mentioned cooling sample carrying plate; the above-mentioned transportation module is used to transport the sample after being cooled by the above-mentioned cooling module to the above-mentioned low-temperature storage module; the above-mentioned low-temperature storage module, the above-mentioned cooling module and the above-mentioned transportation module are all communicatively connected with the above-mentioned control module.

[0008] Optionally, the cooling module also includes a moving mechanism, which is arranged inside the cooling box, and the cooling sample carrier plate is arranged on the moving mechanism; the moving mechanism includes a guide rail, a robotic arm base, a power piece and a locking assembly; the guide rail is fixed to the side inside the cooling box, the robotic arm base is slidably arranged on the guide rail, the power piece is fixed to one end of the guide rail, and the power piece is used to drive the robotic arm base to move on the guide rail.

[0009] Optionally, the cooling mechanism includes a cooling layer, the cooling layer includes a cooling medium, and the cooling medium is located at the bottom of the cooling box; during the cooling process, the moving mechanism drives the cooling sample carrier plate to move to the inside of the cooling medium; the locking assembly includes a vapor layer locking member and a liquid layer locking member, the vapor layer locking member and the liquid layer locking member are both arranged on both sides of the guide rail, and the liquid layer locking member is located below the vapor layer locking member.

[0010] Optionally, the cooling mechanism includes a compressor, a condenser, an evaporator and an expansion valve; the compressor and the condenser are both arranged outside the cooling box, the evaporator is arranged at the inner bottom or inner side of the cooling box, and the expansion valve is arranged at the inlet of the evaporator; the outlet of the compressor is connected to the inlet of the condenser, the outlet of the condenser is connected to the inlet of the evaporator, and the outlet of the evaporator is connected to the inlet of the compressor.

[0011] Optionally, the cooling module also includes a cooling controller, a cooling temperature sensor and a fan. The cooling mechanism, the cooling temperature sensor and the fan are all communicatively connected to the cooling controller. The cooling controller is used to control the fan and the cooling mechanism according to the temperature information detected by the cooling temperature sensor.

[0012] Optionally, the temperature regulating storage device further includes a pre-drying module, which is communicatively connected to the control module; the pre-drying module includes a drying box, a drying sample carrier plate and a drying mechanism, the drying sample carrier plate is provided with at least one drying sample carrier hole, each drying sample carrier hole is used to carry a sample, and the drying mechanism is used to dry each sample carried on the drying sample carrier plate.

[0013] Optionally, the temperature regulating storage device further comprises an information reading module, which is communicatively connected with the control module; the information reading module is connected with the pre-drying module via a sample connecting tube, and the information reading module is connected with the transport module via a dry sample transmission tube, the information reading module comprises a sample fixing part and a sample information reading part, one side of the sample fixing part is connected with the sample connecting tube, and the other side of the sample fixing part is connected with the dry sample transmission tube, when the sample is fixed in the sample fixing part, the sample information reading part reads the electronic tag on the sample; in a working state, the sample dried by the pre-drying module is sucked to the sample fixing part by negative pressure, and the transport module sucks the sample after reading the electronic tag from the sample fixing part and transports it to the cooling module.

[0014] Optionally, the sample fixing part is a hexagonal fixing ring, both sides of the hexagonal fixing ring are covered by transparent material, the lower end of the hexagonal fixing ring is connected to the sample connecting tube, and the side of the hexagonal fixing ring is connected to the dry sample transmission tube; the sample information reader is an electronic tag reader, the sample information reader is arranged on the side of the hexagonal fixing ring, and the sample information reader is communicatively connected to the control module.

[0015] Optionally, the transport module includes a moving electric cylinder, a negative pressure adsorption power part, a rotating sample carrier and at least one group of moving rods; the moving electric cylinder is used to drive the rotating sample carrier to move on the at least one group of moving rods, the negative pressure adsorption power part is used to adsorb the sample into the rotating sample carrier, the rotating sample carrier includes at least one sample carrying hole, each of the at least one sample carrying hole is evenly distributed around the rotating sample carrier, the at least one group of moving rods includes a moving rod located above the cooling module and a moving rod located above the low-temperature storage module; in a working state, the transport module moves above the cooling module and each low-temperature storage unit.

[0016] The above-mentioned various embodiments of the present disclosure have the following beneficial effects: the probability of sample damage can be reduced by the temperature regulating storage device of some embodiments of the present disclosure. Specifically, the reason for the damage to the sample is that when the temperature difference between the storage temperature in the storage device and the room temperature is large, directly placing the sample in the low-temperature storage chamber will cause temperature shock to the sample, and the temperature of the sample will also affect the temperature in the storage device, thereby affecting the storage temperature environment of other samples in the storage device. Based on this, the temperature regulating storage device of some embodiments of the present disclosure includes a control module, a low-temperature storage module, a cooling module and a transportation module, and different low-temperature storage units in the low-temperature storage module are set to different storage temperatures. The cooling module includes a cooling box connected to a cooling sample transmission pipe, a cooling sample carrier plate for carrying samples, and a cooling mechanism for cooling. The transportation module is used to transport the sample cooled by the cooling module to the low-temperature storage module. Because the low-temperature storage module includes low-temperature storage units with different storage temperatures, samples suitable for different storage temperatures can be stored at low temperatures respectively. Because the sample that needs to be stored at low temperature can be transferred to the cooling box through the cooling sample transfer tube, and then placed in the low temperature storage module after pre-cooling through the cooling mechanism, the temperature shock of the sample when placed in the low temperature storage module can be reduced, and the influence of the sample temperature on the temperature inside the low temperature storage module can be reduced, thereby reducing the probability of sample damage. Therefore, the temperature regulating storage device of some embodiments of the present disclosure can reduce the probability of sample damage. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The above and other features, advantages and aspects of the embodiments of the present disclosure will become more apparent with reference to the following detailed description in conjunction with the accompanying drawings. Throughout the accompanying drawings, the same or similar reference numerals represent the same or similar elements. It should be understood that the drawings are schematic and that components and elements are not necessarily drawn to scale.

[0018] Figure 1 is a schematic diagram of the structure of some embodiments of the temperature regulating storage device according to the present disclosure; Figure 2 It is a schematic structural diagram of some embodiments of the cooling module included in the temperature regulating storage device according to the present disclosure. DETAILED DESCRIPTION

[0019] Embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although certain embodiments of the present disclosure are shown in the accompanying drawings, it should be understood that the present disclosure can be implemented in various forms and should not be construed as being limited to the embodiments set forth herein. On the contrary, these embodiments are provided to provide a more thorough and complete understanding of the present disclosure. It should be understood that the drawings and embodiments of the present disclosure are only for exemplary purposes and are not intended to limit the scope of protection of the present disclosure.

[0020] In the description of the present disclosure, it should be noted that, unless otherwise clearly specified and limited, the terms "disposed" and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be the internal communication of two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present disclosure can be understood according to specific circumstances.

[0021] It should also be noted that, for ease of description, only the parts related to the relevant disclosure are shown in the drawings. In the absence of conflict, the embodiments and features in the embodiments of the present disclosure can be combined with each other.

[0022] It should be noted that the concepts such as "first" and "second" mentioned in the present disclosure are only used to distinguish different devices, modules or units, and are not used to limit the order or interdependence of the functions performed by these devices, modules or units.

[0023] It should be noted that the modifications of "one" and "plurality" mentioned in the present disclosure are illustrative rather than restrictive, and those skilled in the art should understand that unless otherwise clearly indicated in the context, it should be understood as "one or more".

[0024] The names of the messages or information exchanged between multiple devices in the embodiments of the present disclosure are only used for illustrative purposes and are not used to limit the scope of these messages or information.

[0025] The present disclosure will be described in detail below with reference to the accompanying drawings and in conjunction with embodiments.

[0026] Figure 1 Schematic diagram of the structure of some embodiments of the temperature regulating storage device according to the present disclosure. Figure 1The low temperature storage module 1 includes a low temperature storage module 1, a cooling module 2, a transport module 3 and a cooling sample transmission tube 4. The low temperature storage module 1 includes a low temperature storage unit 11 and a refrigeration compression mechanism 12.

[0027] Figure 2 It is a schematic structural diagram of some embodiments of the cooling module included in the temperature regulating storage device according to the present disclosure. Figure 2 The cooling module 2 includes a cooling box 21 , a cooling sample carrier plate 22 and a cooling mechanism 23 .

[0028] In some embodiments, the temperature regulating storage device may include a control module, a low temperature storage module 1, a cooling module 2 and a transport module 3. The control module may be a controller for processing various received information and issuing instructions according to the processed information. For example, the control module may be a programmable logic controller. The low temperature storage module 1 may include at least two low temperature storage units (e.g., low temperature storage unit 11). The low temperature storage unit may be a storage box with a refrigeration function. Different low temperature storage units may have different storage temperatures.

[0029] In some embodiments, the low-temperature storage unit may include a refrigeration compression mechanism (e.g., refrigeration compression mechanism 12), a storage tube, and a refrigeration pipeline. The refrigeration compression mechanism may be a refrigeration compressor. The storage tube may be a hollow tube for storing samples. Specifically, each sample may be stacked in the storage tube. The refrigeration pipeline may be a pipeline for transporting refrigerant. The refrigeration compression mechanism may be connected to the refrigeration pipeline. The refrigeration pipeline may be connected to the storage tube. The refrigeration pipeline may be used to transport refrigerant. The outlet of the refrigeration compression mechanism may be connected to the high-pressure end of the refrigeration pipeline. The inlet of the refrigeration compression mechanism may be connected to the low-pressure end of the refrigeration pipeline. The outlet of the refrigeration compression mechanism is connected to a condenser, and the refrigeration pipeline of the condenser transports high-temperature and high-pressure gaseous refrigerant. The inlet of the refrigeration compression mechanism is connected to the refrigeration pipeline to transport low-temperature and low-pressure gaseous refrigerant to the outside of the storage tube. An evaporator may be embedded in the outside of the storage tube, and the high-temperature and high-pressure gaseous refrigerant evaporates and absorbs heat in the evaporator, thereby reducing the temperature of the storage tube.

[0030] In some embodiments, the cooling module 2 may include a cooling box 21, a cooling sample carrier plate 22 and a cooling mechanism 23. A cooling sample transfer tube 4 may be provided above the cooling module 2. The cooling sample transfer tube 4 is a pipe used to transfer samples to the cooling module 2. A transfer hole may be provided on the cooling box 21. The transfer hole may be an opening for passing samples. The cooling box 21 may be connected to the cooling sample transfer tube 4 through the transfer hole. Samples may be placed in the cooling box 21 through the cooling sample transfer tube 4. Samples cooled in the cooling box 21 may also be sucked through the cooling sample transfer tube 4. The cooling sample carrier plate 22 may be located inside the cooling box 21. At least one cooling sample carrying hole may be provided on the cooling sample carrier plate 22. Each cooling sample carrying hole may be used to carry samples. The cooling mechanism 23 may be used to pre-cool each sample carried on the cooling sample carrier plate 22. Specifically, the cooling mechanism 23 can cool down each sample carried on the cooling sample carrier plate 22 to a preset temperature according to a preset cooling frequency.

[0031] In some embodiments, the transport module 3 may be used to transport the sample cooled by the cooling module 2 to the low-temperature storage module 1. The transport module 3 may be a mechanism for moving the sample. The low-temperature storage module 1, the cooling module 2 and the transport module 3 may all be connected to the control module for communication.

[0032] Optionally, the cooling module 2 may further include a moving mechanism. The moving mechanism may be arranged inside the cooling box 21. The cooling sample carrier plate 22 may be arranged on the moving mechanism. The moving mechanism may include a guide rail, a robot base, a power member and a locking assembly. The robot base may include a slider, a robot arm and a carrier plate fixing member. The carrier plate fixing member may be a component for fixing the cooling sample carrier plate 22. For example, the carrier plate fixing member may be a clamp or a suction cup. The power member may be an electric cylinder. The guide rail is fixed to the side inside the cooling box 21. The robot base may be slidably arranged on the guide rail. Specifically, the slider may be slidably arranged on the guide rail. The power member may be fixed to one end of the guide rail. The power member may be used to drive the robot base to move on the guide rail. Specifically, the piston rod of the power member may be connected to the slider through a coupling or a joint to drive the slider to move. Thus, the cooling sample carrier plate can be driven to move up and down by the guide rail, the power member and the slider, and the cooling sample carrier plate can be driven to move left and right and forward and backward by the mechanical arm, so that the cooling sample carrier hole on the cooling sample carrier plate can be aligned with the transmission hole.

[0033] Optionally, the cooling mechanism 23 may include a cooling layer. The cooling layer may include a cooling medium. The cooling medium may be liquid nitrogen (-196°C) or a dry ice-ethanol mixture (-78°C). The cooling medium may be located at the bottom of the cooling box 21. During the cooling process, the moving mechanism may drive the cooling sample carrier plate 22 to move to the inside of the cooling medium. The locking assembly may include a vapor layer locking member and a liquid layer locking member. Both the vapor layer locking member and the liquid layer locking member may be mechanical clamps or electromagnetic locks. Both the vapor layer locking member and the liquid layer locking member may be fixed to both sides of the guide rail by bolts. Both the vapor layer locking member and the liquid layer locking member may be arranged on both sides of the guide rail. The liquid layer locking member may be located below the vapor layer locking member. The vapor layer locking member and the liquid layer locking member may be used to lock the slider. When the power member provides a large power, the slider may be disengaged from the vapor layer locking member and the liquid layer locking member. Therefore, by directly immersing the sample in the cryogenic liquid for cooling, the cooling speed can be increased, the formation of ice crystals can be reduced, and the sample is in direct contact with the cooling medium, the heat transfer is uniform, and the problem of local overheating or uneven cooling can be avoided. And by setting the vapor layer locking member and the liquid layer locking member, the sample can be immersed in the cryogenic liquid vapor layer for pre-cooling first, and then completely immersed in the liquid to reduce the damage of thermal stress to the sample.

[0034] Optionally, the cooling mechanism 23 may include a compressor, a condenser, an evaporator and an expansion valve. The compressor and the condenser may be arranged outside the cooling box 21. The evaporator may be arranged inside the cooling box 21. The expansion valve may be arranged at the inlet of the evaporator. The outlet of the compressor may be communicated with the inlet of the condenser. The outlet of the condenser may be communicated with the inlet of the evaporator. The outlet of the evaporator may be communicated with the inlet of the compressor. Thus, compared with cooling and cooling by a cooling medium, cooling and cooling the sample by a refrigerant may provide a wider range of cooling temperature, thereby increasing the scope of application of the cooling module.

[0035] Optionally, the cooling module 2 may further include a cooling controller, a cooling temperature sensor and a fan. The cooling controller may be a central processing unit. The cooling mechanism 23, the cooling temperature sensor and the fan may be connected to the cooling controller in communication. The cooling controller may be used to control the fan and the cooling mechanism 23 according to the temperature information detected by the cooling temperature sensor. Specifically, the cooling controller may input the temperature information detected by the cooling temperature sensor and the cooling information corresponding to the sample into a pre-trained speed information generation model to generate speed information. The pre-trained speed information generation model may be a machine learning model that takes the speed information and the temperature information as input and the speed information as output. For example, the pre-trained speed information generation model may be a support vector machine. And a compression power information generation model that pre-trains the temperature information detected by the cooling temperature sensor and the cooling information corresponding to the sample to generate compression power information. The pre-trained compression power information generation model may be a machine learning model that takes the speed information and the temperature information as input and the compression power information as output. For example, the pre-trained compression power information generation model may be a decision tree. Then, the speed of the fan is adjusted to the speed represented by the speed information, and the compression power of the compressor included in the cooling mechanism 23 is adjusted to the compression power represented by the compression power information. Thus, controlling the fan and the cooling mechanism according to the temperature information detected by the cooling temperature sensor can pre-cool the sample more accurately, further reducing the probability of sample damage to improve sample safety.

[0036] In the process of adopting technical solutions to solve the above technical problems, the following technical problem 2 is often accompanied: when the sample is pre-cooled by a program-controlled cooling device, the cooling speed is slow, and cooling multiple samples may cause uneven cooling of the samples, resulting in damage to the samples when they are subsequently stored at low temperatures. In response to the above technical problem 2, the conventional solution is generally to quickly cool the sample by immersing it in liquid nitrogen. However, the above conventional solution still has the following problems: liquid nitrogen immersion can cool the sample evenly and quickly, but it may cause thermal stress, especially if it is directly from high temperature to liquid nitrogen, which can easily cause sample rupture or structural damage.

[0037] Considering the problems of the above conventional solutions, facing the above technical problem 2: when the sample is pre-cooled by the program-controlled cooling device, the cooling speed is slow, and when cooling multiple samples, the sample cooling may be uneven, resulting in damage to the sample when it is subsequently stored at low temperature. Combined with the current technical status, it can be decided to adopt the following solution: Optionally, the cooling mechanism 23 may further include a rotary nozzle and a centrifugal fan. The centrifugal fan may be arranged behind the evaporator. The rotary nozzle may be arranged at the outlet of the centrifugal fan. The outlet of the centrifugal fan may be connected to the rotary nozzle. The centrifugal fan may be used to inhale the cold air generated by the evaporator and pressurize it. The centrifugal fan may also be used to deliver the pressurized cold air to the rotary nozzle. The rotary nozzle is used to eject the cold air. At least one inclined hole may be provided on the side of the rotary nozzle. Each of the at least one inclined hole may be evenly distributed around the rotary nozzle. The cold air ejected by the rotary nozzle may diffuse in an umbrella shape. The rotary nozzle may be arranged on the interior of the cooling box 21. During the pre-cooling process of the cooling module 2, the cooling sample carrier 22 may be located below the rotary nozzle. The interior of the rotary nozzle may be provided with spiral blades. When the cold air passes through the spiral blades, the spiral blades may rotate to drive the rotary nozzle to rotate.

[0038] Optionally, the cooling module 2 may further include a cooling controller, an ambient temperature sensor and a cooling temperature sensor. The ambient temperature sensor may be a temperature sensor disposed outside the cooling box 21. The cooling temperature sensor may be a temperature sensor inside the cooling box 21. The cooling mechanism 23 and the moving mechanism may both be connected to the cooling controller in communication. The cooling controller may be configured to perform the following steps: The first step is to obtain the pre-cooling sample information. The pre-cooling sample information includes the sample quantity, sample type, sample storage temperature and sample heat capacity. The sample quantity can be the number of samples. The sample type can be the type to which the sample belongs. For example, the sample type can be a biological sample, a chemical reagent or a material. The sample storage temperature can be the temperature at which the sample is stored at low temperature. The sample heat capacity can be the amount of heat added when the sample temperature rises by 1K. In practice, the temperature reduction controller can obtain the pre-cooling sample information from the control module. The pre-cooling sample information stored in the control module can be input by the user.

[0039] The second step is to determine the sample distribution position information corresponding to each sample in the cooling sample carrier plate according to the above-mentioned sample quantity. The above-mentioned sample distribution position information may be information characterizing the positions of each sample distributed in the above-mentioned cooling sample carrier plate. In practice, the above-mentioned cooling controller may filter out the preset sample distribution position information corresponding to the above-mentioned sample quantity from the preset sample distribution position information configuration table as the sample distribution position information. The above-mentioned preset sample distribution position information configuration table may be a configuration table pre-set to characterize the correspondence between the sample quantity and the preset sample distribution position information. For example, when the above-mentioned sample quantity is one sample, the above-mentioned sample distribution position information may be (1, 1). The above-mentioned (1, 1) may be the first row and the first column.

[0040] The third step is to control the robot base to perform a moving operation in response to receiving the sample transportation instruction information sent by the control module according to the sample distribution position information. The sample transportation instruction information may be information characterizing the transportation of the sample into the cooling module. In practice, first, the cooling controller may generate a moving path corresponding to the robot base according to the sample distribution position information. Specifically, the cooling controller may select a preset moving path corresponding to the sample distribution position information from a preset moving path configuration table as a moving path. The preset moving path configuration table may be a configuration table that pre-sets the correspondence between the sample distribution position information and the preset moving path. Then, the cooling controller may control the robot base to perform a moving operation according to the moving path.

[0041] The fourth step is to collect the current room temperature through the associated ambient temperature sensor and collect the cooling temperature through the cooling temperature sensor.

[0042] The fifth step is to select a preset cooling rate information generation model corresponding to the above sample type from the preset cooling rate information generation model set according to the above sample type. The above preset cooling rate information generation model can be a pre-trained machine learning model with sample storage temperature, cooling temperature, current room temperature and sample heat capacity as input and cooling rate information as output. For example, the above preset cooling rate information generation model can be a random forest model. The above cooling rate information can include a safe cooling rate and a phase transition point temperature.

[0043] In the sixth step, the sample storage temperature, the cooling temperature, the current room temperature and the sample heat capacity are input into a preset cooling rate information generation model to obtain cooling rate information.

[0044] Step 7: According to the above cooling rate information, control the above compressor to perform the cooling operation corresponding to the above cooling rate information. In practice, the above cooling controller can control the above compressor to perform the cooling operation corresponding to the above cooling rate information through a PID (proportion integration differentiation) control algorithm. Specifically, the above cooling controller can dynamically adjust the cooling rate within the safe cooling rate by controlling the above compressor and reduce the rate near the phase change point.

[0045] Step 8: Control the moving mechanism to perform cooling movement operation. In practice, the temperature reduction controller can control the power element to drive the robot arm base to move to the vapor layer and liquid layer corresponding to the cooling layer in sequence to perform rapid and uniform cooling.

[0046] The above-mentioned contents related to the cooling module serve as an inventive point of an embodiment of the present disclosure, and solve the second technical problem "When the sample is pre-cooled by the program-controlled cooling device, the cooling speed is slow, and when cooling multiple samples, the sample may be cooled unevenly, resulting in damage to the sample when the sample is subsequently stored at a low temperature". The reasons for the damage to the sample are as follows: When the sample is pre-cooled by the program-controlled cooling device, the cooling speed is slow, and when cooling multiple samples, the sample may be cooled unevenly. If the above factors are solved, the damage to the sample can be reduced. In order to achieve this effect, the cooling mechanism in the temperature regulating and storage device of the present disclosure sets a rotating nozzle so that the ejected cold air can be diffused in an umbrella shape, so that the sample can be cooled more evenly. And the cooling rate is determined according to information such as the sample type, sample storage temperature and sample heat capacity, so as to adopt a dynamic cooling rate adjustment that is more in line with the characteristics of the sample, thereby improving the sample cooling efficiency while improving the sample safety. In addition, staged temperature control is adopted. The temperature is first cooled through the program module to avoid thermal stress or ice crystal damage caused by sudden temperature changes, and then the temperature is quickly cooled by direct immersion in the cooling layer, which improves the cooling uniformity and efficiency of the sample.

[0047] Optionally, the temperature regulating storage device may further include a pre-drying module. The pre-drying module is communicatively connected with the control module. The pre-drying module may include a drying oven, a dry sample carrier plate and a drying mechanism. The drying mechanism may be a wind speed, a desiccant or a vacuum pump. At least one dry sample carrier hole may be provided on the dry sample carrier plate. Each dry sample carrier hole may be used to carry a sample. The drying mechanism may be used to dry each sample carried on the dry sample carrier plate. Thus, the moisture or other solvents outside the sample are removed by the pre-drying module to facilitate subsequent information reading and storage.

[0048] Optionally, the temperature regulating storage device may further include an information reading module. The information reading module may be connected to the control module in communication. The information reading module may be connected to the pre-drying module through a sample connecting tube. The information reading module may be connected to the transport module 3 through a dry sample transmission tube. The information reading module may include a sample fixing member and a sample information reading member. Among them, the sample information reading member may be a card reader or a QR code scanner. One side of the sample fixing member may be connected to the sample connecting tube. The other side of the sample fixing member may be connected to the dry sample transmission tube. When the sample is fixed in the sample fixing member, the sample information reading member may read the electronic tag on the sample. The information in the electronic tag may include cooling information and storage temperature information. In the working state, the sample dried by the pre-drying module may be sucked to the sample fixing member by negative pressure. The transport module 3 may suck the sample after reading the electronic tag from the sample fixing place and transport it to the cooling module 2. Thus, various information of the sample may be read by the information reading module to facilitate subsequent cooling and storage.

[0049] Optionally, the sample fixing member may be a hexagonal fixing ring. Both sides of the hexagonal fixing ring may be covered by a transparent material. The transparent material may facilitate the sample information reader to read the electronic tag on the sample. The lower end of the hexagonal fixing ring may be connected to the sample connecting tube. The side of the hexagonal fixing ring may be connected to the dry sample transmission tube. The sample information reader may be an electronic tag reader. The sample information reader may be arranged on the side of the hexagonal fixing ring. The sample information reader may be connected to the control module for communication. Therefore, because the dry sample transmission tube and the sample connecting tube are not in the same straight line, the sample may rotate to a certain extent when the sample is sucked, thereby making it easier for the sample information reader to read the electronic tag on the sample.

[0050] Optionally, the transport module 3 may include a moving electric cylinder, a negative pressure adsorption power part, a rotating sample carrier and at least one group of moving rods. The moving electric cylinder may be used to drive the rotating sample carrier to move on the at least one group of moving rods. The negative pressure adsorption power part may be used to adsorb the sample into the rotating sample carrier. The rotating sample carrier may include at least one sample carrying hole. The at least one sample carrying hole may be evenly distributed around the rotating sample carrier. The at least one group of moving rods may include a moving rod located above the cooling module 2 and a moving rod located above the low temperature storage module 1. In working state, the transport module 3 may move above the cooling module 2 and each low temperature storage unit.

[0051] The above descriptions are only some preferred embodiments of the present disclosure and an explanation of the technical principles used. Those skilled in the art should understand that the scope of the invention involved in the embodiments of the present disclosure is not limited to the technical solutions formed by a specific combination of the above technical features, but should also cover other technical solutions formed by any combination of the above technical features or their equivalent features without departing from the above inventive concept. For example, the above features are replaced with (but not limited to) technical features with similar functions disclosed in the embodiments of the present disclosure.

Claims

1. A temperature regulating storage device, characterized in that: It includes a control module, a low-temperature storage module, a cooling module and a transportation module, wherein: The low temperature storage module comprises at least two low temperature storage units, and different low temperature storage units are set to different storage temperatures; The low-temperature storage unit comprises a refrigeration compression mechanism, a storage tube and a refrigeration pipeline, wherein the refrigeration compression mechanism is connected to the refrigeration pipeline, the refrigeration pipeline is connected to the storage tube, and the refrigeration pipeline is used to transport the refrigerant; The cooling module comprises a cooling box, a cooling sample carrier plate and a cooling mechanism, a cooling sample transmission tube is arranged above the cooling module, a transmission hole is opened on the cooling box, the cooling box is connected with the cooling sample transmission tube through the transmission hole, the cooling sample carrier plate is located inside the cooling box, at least one cooling sample bearing hole is arranged on the cooling sample carrier plate, each cooling sample bearing hole is used to carry a sample, and the cooling mechanism is used to pre-cool each sample carried on the cooling sample carrier plate; The transport module is used to transport the sample cooled by the cooling module to the low-temperature storage module; The low-temperature storage module, the cooling module and the transportation module are all communicatively connected with the control module.

2. The temperature regulating storage device according to claim 1, characterized in that: The cooling module further comprises a moving mechanism, which is arranged inside the cooling box, and the cooling sample carrier plate is arranged on the moving mechanism; The moving mechanism comprises a guide rail, a mechanical arm base, a power piece and a locking assembly; The guide rail is fixed to the side of the cooling box, the robot arm base is slidably arranged on the guide rail, the power piece is fixed to one end of the guide rail, and the power piece is used to drive the robot arm base to move on the guide rail.

3. The temperature regulating storage device according to claim 2, characterized in that: The cooling mechanism comprises a cooling layer, the cooling layer comprises a cooling medium, and the cooling medium is located at the bottom of the cooling box; During the cooling process, the moving mechanism drives the cooling sample carrier to move into the interior of the cooling medium; The locking assembly comprises a vapor layer locking member and a liquid layer locking member, wherein the vapor layer locking member and the liquid layer locking member are both arranged on both sides of the guide rail, and the liquid layer locking member is located below the vapor layer locking member.

4. The temperature regulating storage device according to claim 3, characterized in that: The cooling mechanism also includes a compressor, a condenser, an evaporator and an expansion valve; The compressor and the condenser are both arranged outside the cooling box, the evaporator is arranged inside the cooling box, and the expansion valve is arranged at the inlet of the evaporator; The outlet of the compressor is communicated with the inlet of the condenser, the outlet of the condenser is communicated with the inlet of the evaporator, and the outlet of the evaporator is communicated with the inlet of the compressor.

5. The temperature regulating storage device according to claim 4, characterized in that: The cooling module also includes a cooling controller, a cooling temperature sensor and a fan. The cooling mechanism, the cooling temperature sensor and the fan are all communicatively connected to the cooling controller. The cooling controller is used to control the fan and the cooling mechanism according to the temperature information detected by the cooling temperature sensor.

6. The temperature regulating storage device according to claim 1, characterized in that: The temperature regulating storage device further comprises a pre-drying module, and the pre-drying module is communicatively connected with the control module; The pre-drying module includes a drying box, a drying sample carrier plate and a drying mechanism. The drying sample carrier plate is provided with at least one drying sample carrying hole, each drying sample carrying hole is used to carry a sample, and the drying mechanism is used to dry each sample carried on the drying sample carrier plate.

7. The temperature regulating storage device according to claim 6, characterized in that: The temperature adjustment storage device further comprises an information reading module, and the information reading module is communicatively connected with the control module; The information reading module is connected to the pre-drying module through a sample connecting tube, and is connected to the transport module through a dry sample transmission tube. The information reading module includes a sample fixing part and a sample information reading part. One side of the sample fixing part is connected to the sample connecting tube, and the other side of the sample fixing part is connected to the dry sample transmission tube. When the sample is fixed in the sample fixing part, the sample information reading part reads the electronic tag on the sample. In the working state, the sample dried by the pre-drying module is sucked to the sample fixing part by negative pressure, and the transport module sucks the sample after reading the electronic tag from the sample fixing part and transports it to the cooling module.

8. The temperature regulating storage device according to claim 7, characterized in that: The sample fixing member is a hexagonal fixing ring, both sides of which are covered by a transparent material, the lower end of the hexagonal fixing ring is connected to the sample connecting tube, and the side of the hexagonal fixing ring is connected to the dry sample transmission tube; The sample information reader is an electronic tag reader, and the sample information reader is arranged on the side of the hexagonal fixing ring, and the sample information reader is communicatively connected with the control module.

9. The temperature regulating storage device according to any one of claims 1 to 8, characterized in that: The transport module includes a mobile electric cylinder, a negative pressure adsorption power part, a rotating sample carrier plate and at least one set of mobile rods; The mobile electric cylinder is used to drive the rotating sample carrier to move on the at least one group of moving rods, and the negative pressure adsorption power member is used to adsorb the sample into the rotating sample carrier. The rotating sample carrier includes at least one sample carrying hole, and each of the at least one sample carrying hole is evenly distributed around the rotating sample carrier. The at least one group of moving rods includes a moving rod located above the cooling module and a moving rod located above the low-temperature storage module. In a working state, the transport module moves above the cooling module and each low-temperature storage unit.

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