Auxiliary tool for extracting testis of mouse

Abstract

The auxiliary tool comprises a base, the end of the base is provided with a conically-arranged binding cavity, the base is provided with a limiting piece used for fastening the lower limbs of the mouse, the two sides of the base are provided with blocking walls, the end, provided with an opening, of the binding cavity extends towards the position between the two blocking walls to form a supporting beam, and the supporting beam is provided with a limiting piece used for limiting the lower limbs of the mouse. Two comb arms which are hinged to each other are arranged on the supporting beam, comb teeth used for scraping hair open are arranged at one ends of the comb arms, driving parts are arranged at the other ends of the comb arms, an adsorption plate is further arranged on the blocking wall, and the adsorption plate is connected with an electrostatic generator used for enabling the adsorption plate to carry static electricity. The testis extractor is simple in structure, can effectively assist in testis extraction, can effectively avoid the influence of fur, and has a good use effect.

Description

Technical Field

[0001] The invention relates to a medical experiment instrument, in particular to an auxiliary tool for extracting mouse testicles. Background Art

[0002] Laboratory mice are widely used in medical experiments and play a significant role in reproductive system research. Their reproductive system has outstanding characteristics, such as the male groin is open throughout life and the female has a Y-shaped bicornuate uterus. It can be used for the development of reproductive drugs and to evaluate the effects of drugs on reproductive function, including the effects on conception rate and embryonic development. By constructing reproductive system disease models, such as mouse models of premature ovarian failure and oligospermia, we can deeply explore the pathogenesis of the disease and develop new treatment methods. In addition, it can also be used to study the impact of environmental factors on the reproductive system, providing an important reference for protecting human reproductive health. Mouse testicles are also extracted in the laboratory, and some cells in the mouse testicles are extracted, such as SLCs and macrophages are isolated from the mouse testicles, and their proliferation and differentiation potential are compared in vitro to verify drug or hormone expression. In the existing extraction process of mouse testicles, due to the small size of mouse testicles, injection positioning is inconvenient, and they are very sensitive. When stimulated, they easily shrink into the groin, affecting the stripping operation. Therefore, at present, at least two operators are required to perform the testicular stripping operation, and the fur on the mouse abdomen will greatly interfere with the testicular stripping action, which greatly affects the progress of the experiment and easily causes waste of manpower. Summary of the invention

[0003] In view of the deficiencies in the prior art, the present invention provides an auxiliary tooling for extracting mouse testicles, which has a simple structure, can effectively assist in testicle removal, and can effectively avoid the influence of fur, thereby having a good use effect.

[0004] To achieve the above-mentioned purpose, the present invention provides an auxiliary tooling for extracting mouse testicles, comprising a base, a conical restraining cavity is arranged at the end of the base, a limiting piece for fastening the lower limbs of the mouse is arranged on the base, retaining walls are arranged on both sides of the base, a support beam is extended between the two retaining walls at one end of the restraining cavity opening, two hinged comb arms are arranged on the support beam, one end of the comb arm is provided with comb teeth for scraping off hair, the other end of the comb arm is a driving part, an adsorption plate is also arranged on the retaining wall, and the adsorption plate is connected to an electrostatic generator for making the adsorption plate carry static electricity.

[0005] The beneficial effect of such arrangement is as follows: such arrangement, first, the restraint cavity with a conical arrangement at the end of the base can closely fit the shape of the mouse head, provide a stable restraint space for the mouse, and cooperate with the limiter to prevent the mouse from twitching the lower limbs during the entire operation, thereby ensuring the stability of the operating environment, effectively limiting the large-scale movement of the body due to muscle twitching, ensuring that the mouse remains relatively still during the operation, and facilitating the operator to concentrate on the subsequent testicle removal action. Further, through the comb arm hinged on the support beam, the comb teeth at one end can achieve reciprocating motion under the action of the driving unit. This design can efficiently and evenly push the hair of the mouse's lower abdomen to the left and right sides, quickly and accurately clean up the operating area, and greatly improve the efficiency of exposing the genitals. The adsorption plate connected to the electrostatic generator can quickly adsorb the hair pushed away by the comb teeth after being electrostatically charged, firmly position the hair, and avoid it from covering the operating area again, so that the genitals can be fully exposed, providing a clear and unobstructed operating field for the operator, and significantly improving the accuracy and success rate of the testicle removal action.

[0006] As a further configuration of the present invention, a connecting ball head is rotatably provided on the support beam, a hinge column is provided on the connecting ball head, and two comb arms are cross-arranged and rotatably connected to the hinge shafts respectively.

[0007] The beneficial effect of this arrangement is that this arrangement gives the ability to fine-tune the angle of the comb arm through the connecting ball head that is rotatably set on the support beam and the hinged column on the connecting ball head. In actual operation, there are differences in the body shape and hair distribution of mice. This design allows operators to flexibly adjust the angle of the comb arm according to the specific situation. Whether the hair density is different or the shape of the mouse's abdomen is slightly different, the comb arm can be fine-tuned so that the comb teeth contact the hair at the best angle and the hair can be evenly spread out more efficiently. This not only improves the efficiency of hair cleaning, but also ensures the accuracy of the operation, avoids unnecessary damage to the mouse skin due to improper angles, and provides a more ideal hair cleaning effect for subsequent testicle removal operations.

[0008] As a further configuration of the present invention, a support spring for keeping the comb arms open is arranged between the comb arms, a positioning pin is arranged on the comb arm corresponding to the position of the support spring, and the support spring is sleeved on the positioning pin.

[0009] The beneficial effect of this arrangement is that, in the actual operation process, the support spring always provides the comb arm with an outward opening force, and the operator does not need to continuously exert force to maintain the comb arm in an open state, which effectively reduces hand fatigue, makes the operation of the comb arm easier and more convenient, and allows more attention to be focused on the precise action of hair cleaning. When the operator completes the hair-pushing action and disengages from the operation of the comb arm, the characteristic of the support spring to maintain the comb arm open produces a good synergistic effect with the adsorption plate. The comb arm remains open, which can make the already-pushed hair more fully exposed to the action range of the adsorption plate. After the adsorption plate is charged with static electricity, the hair can be positioned more efficiently, further ensuring that the operation area is clear and unobstructed, creating more favorable conditions for the subsequent precise removal of mouse testicles.

[0010] As a further configuration of the present invention, an adjustment groove is provided on the base along the length direction, an adjustment seat is slidably provided in the adjustment groove, a driving wheel and a driving motor for driving the driving wheel to rotate are provided on the adjustment seat, the driving wheel includes a connecting shaft and two cams, and the cams are connected to the connecting shaft.

[0011] The beneficial effect of such a setting is that the adjustment groove arranged along the length direction on the base is matched with the adjustment seat sliding therein, which facilitates the flexible adjustment of the driving wheel, adapts to the sizes of mice of different sizes, and ensures that the adjustment seat can be adjusted to the position near the mouse testicles. The driving motor on the adjustment seat drives the driving wheel to rotate, and the driving wheel is composed of a connecting shaft and two cams. In the process of extracting mouse testicles, muscle tension is a common problem, especially the muscles near the mouse buttocks and legs. As the cam continues to rotate, its unique contour can regularly press and relax the muscles of the corresponding parts of the mouse. This continuous massage effect effectively avoids the occurrence of muscle spasms. Once the mouse has muscle spasms, it is very easy to cause the testicles to shrink into the groin, which will seriously interfere with the testicle extraction operation and may even prevent the experiment from proceeding normally. The cam design of the tooling ensures that the testicles are always in a position that is convenient for extraction by maintaining the relaxed state of the mouse muscles.

[0012] As a further configuration of the present invention, an angle formed by projections of the two cam protruding ends on the plane where the retaining wall is located is 137-153°.

[0013] The beneficial effect of this setting is that the angle design ensures that the cams can perform targeted pressing and relaxation on muscles in different parts in a sequential order. When one cam first acts on the leg muscles on one side to effectively relieve the tension of the muscles on that side, the other cam then acts on the other side. This sequential massage method can accurately adapt to the characteristics of the muscles of both legs and reduce the possibility of muscle spasms in all directions. With the specific angle design between the cams, the continuity and efficiency of mouse muscle relaxation are guaranteed, so that the mouse muscles are always in a relaxed state, ensuring the stability of the testicles, and greatly improving the stability and success rate of experimental operations.

[0014] As a further configuration of the present invention, a restraint groove is provided on the restraint cavity, a positioning hole is provided on the base corresponding to the position of the restraint groove, a restraint buckle is provided in the restraint groove, the restraint buckle includes a holding portion, a pressing buckle portion and a matching portion, the matching portion is plugged into and matched with the positioning hole to fix the restraint buckle in the restraint groove, the pressing buckle portion is arranged in an arc shape, and the holding portion is exposed outside the restraint groove.

[0015] The beneficial effect of such a setting is that the restraint buckle has an exquisite structure, consisting of a gripping part, a pressing buckle part and a matching part. After the operator places the mouse in the restraint cavity, he can easily hold the gripping part exposed outside the restraint slot and insert the restraint buckle along the restraint slot. At this time, the matching part precisely plugs into the positioning hole to quickly form a stable fixation of the restraint buckle in the restraint slot. The pressing buckle part is set in an arc shape. This design fits the physiological curve of the mouse neck. During the fixation process, it can effectively limit the range of movement of the mouse neck without causing excessive pressure on the mouse, ensuring the stable positioning of the mouse. By accurately limiting the mouse neck, the position deviation caused by the twisting of the mouse body can be greatly reduced, which effectively ensures the position stability of the mouse during the entire testicular extraction operation. This not only provides a stable operating object for the operator, reduces the operating interference caused by the change of the mouse position, but also helps to improve the accuracy and success rate of the experimental operation.

[0016] As a further configuration of the present invention, the buckle portion is elastically configured.

[0017] The beneficial effect of this setting is that the elastically set buckle part can automatically adjust the degree of fit according to the actual thickness of the mouse's neck. For mice with thin necks, the buckle part will be appropriately tightened under the action of elasticity to ensure effective positioning; while for mice with slightly thicker necks, the buckle part can be elastically expanded to avoid excessive compression. This adaptive characteristic not only makes the restraint buckle suitable for mice of all sizes.

[0018] As a further configuration of the present invention, the limiting member is elastically configured, one end of the limiting member is connected to the base, and the other end is bent to form a crank arm, and a limiting groove for engaging with the crank arm is provided on the side wall of the base.

[0019] The beneficial effect of such arrangement is that the limiting member is arranged in such a way that after the mouse is placed on the base, the limiting member is swung so that the limiting member contacts the lower limbs of the mouse, and then the crooked arm of the limiting member is stuck in the limiting groove, thereby forming a counter-pressure limit. This structure is simple, can be effectively fixed, and has a good use effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a structural schematic diagram of an embodiment of the present invention; Figure 2 It is a schematic diagram of the structure of the restraining chamber in an embodiment of the present invention; Figure 3 It is a structural schematic diagram of the adjustment seat in an embodiment of the present invention; Figure 4 Schematic diagram of the structure of the restraint buckle in an embodiment of the present invention. DETAILED DESCRIPTION

[0021] The auxiliary tooling for extracting mouse testicles of the present invention is implemented as follows: Figures 1 to 4As shown: it includes a base 1, a conical restraint cavity 2 is provided at the end of the base 1, a limiter 14 for fastening the lower limbs of the mouse is provided on the base 1, baffle walls 11 are provided on both sides of the base 1, a support beam 21 is extended from one end of the opening of the restraint cavity 2 to between the two baffle walls 11, two hinged comb arms 3 are provided on the support beam 21, one end of the comb arm 3 is provided with comb teeth 31 for scraping hair, the other end of the comb arm 3 is a driving part, and an adsorption plate 12 is also provided on the baffle wall 11, and the adsorption plate 12 is connected to an electrostatic generator for making the adsorption plate 12 have static electricity. The beneficial effect of such arrangement is as follows: such arrangement, first, the restraint cavity 2 of the conical arrangement of the end of the base 1 can closely fit the shape of the mouse head, provide a stable restraint space for the mouse, and cooperate with the stopper 14 to make the mouse unable to twitch the lower limbs during the whole operation process, thereby ensuring the stability of the operating environment, effectively limiting the large movement of the body due to muscle twitching, ensuring that the mouse remains relatively still during the operation process, and facilitating the operator to concentrate on the subsequent testicle removal action, and further, through the comb arm 3 hinged on the support beam 21, the comb teeth 31 at one end thereof can realize reciprocating motion under the action of the driving part. This design can efficiently evenly push the hair of the lower abdomen of the mouse to the left and right sides, quickly and accurately clean out the operating area, and greatly improve the efficiency of exposing the genitals. The adsorption plate 12 connected to the electrostatic generator can quickly adsorb the hair pushed away by the comb teeth 31 after being electrostatically charged, firmly position the hair, avoid it from covering the operating area again, and fully expose the genitals, provide a clear and unobstructed operating field for the operator, and significantly improve the accuracy and success rate of the testicle removal action.

[0022] As a further configuration of this embodiment, a connecting ball head 22 is rotatably provided on the support beam 21, and a hinged column is provided on the connecting ball head 22, and two comb arms 3 are cross-arranged and respectively rotatably connected to the hinge shaft. The beneficial effect of such configuration is that such configuration gives the comb arm 3 the ability to fine-tune the angle through the connecting ball head 22 rotatably provided on the support beam 21 and the hinged column on the connecting ball head 22. In actual operation, there are differences in the body shape and hair distribution of mice. This design allows the operator to flexibly adjust the angle of the comb arm 3 according to the specific situation. Whether the hair density is different or the mouse abdomen shape is slightly different, the comb arm 3 can be fine-tuned to make the comb teeth 31 contact the hair at the best angle, and the hair can be evenly spread more efficiently. This not only improves the efficiency of cleaning hair, but also ensures the accuracy of the operation, avoids unnecessary damage to the mouse skin due to improper angles, and provides a more ideal hair cleaning effect for subsequent testicle removal operations.

[0023] As a further configuration of this embodiment, a support spring 32 is provided between the comb arms 3 for keeping the comb arms 3 open, and a positioning pin is provided on the comb arm 3 at a position corresponding to the support spring 32, and the support spring 32 is sleeved on the positioning pin. The beneficial effect of such a configuration is that, in the actual operation process, the support spring 32 always provides the comb arm 3 with an outward opening force, and the operator does not need to continuously exert force to maintain the comb arm 3 in an open state, which effectively reduces hand fatigue, makes the operation of the comb arm 3 easier and more convenient, and can focus more energy on the precise action of hair cleaning. When the operator completes the hair-pushing action and disengages from the operation of the comb arm 3, the characteristic of the support spring 32 to maintain the comb arm 3 open produces a good synergistic effect with the adsorption plate 12. The comb arm 3 remains open, which can make the hair that has been pulled apart more fully exposed within the action range of the adsorption plate 12. After the adsorption plate 12 is charged with static electricity, the hair can be positioned more efficiently, further ensuring that the operation area is clear and unobstructed, creating more favorable conditions for the subsequent precise removal of mouse testicles.

[0024] As a further configuration of this embodiment, an adjustment groove 13 is provided on the base 1 along the length direction, an adjustment seat 4 is slidably provided in the adjustment groove 13, a driving wheel and a driving motor for driving the driving wheel to rotate are provided on the adjustment seat 4, the driving wheel includes a connecting shaft and two cams 41, and the cam 41 is connected to the connecting shaft. The beneficial effect of such a setting is as follows: such a setting, the adjustment groove 13 arranged along the length direction on the base 1, with the adjustment seat 4 sliding therein, provides convenience for the flexible adjustment of the driving wheel, adapts to the sizes of mice of different sizes, ensures that the adjustment seat 4 can be adjusted to the position near the mouse testicles, and the driving motor on the adjustment seat 4 drives the driving wheel to rotate, and the driving wheel is composed of a connecting shaft and two cams 41. In the process of extracting mouse testicles, muscle tension is a common problem, especially the muscles near the mouse buttocks and legs. As the cam 41 continues to rotate, its unique contour can regularly press and relax the muscles of the corresponding parts of the mouse. This continuous massage effect effectively avoids the occurrence of muscle spasms. Once the mouse has muscle spasms, it is very easy to cause the testicles to shrink into the groin, which will seriously interfere with the testicle extraction operation and may even make the experiment unable to proceed normally. The cam 41 design of the tooling ensures that the testicles are always in a position that is convenient for extraction by maintaining the relaxed state of the mouse muscles.

[0025] As a further configuration of the present embodiment, the angle formed by the projections of the protruding ends of the two cams 41 on the plane where the retaining wall 11 is located is 145°. The beneficial effect of such a configuration is that such a configuration ensures that the angle design ensures that the cams 41 can perform targeted pressing and relaxation on muscles in different parts in a sequential order. When one cam 41 first acts on the leg muscles on one side to effectively relieve the muscle tension on that side, the other cam 41 then acts on the other side. This sequential massage method can accurately adapt to the characteristics of the muscles of both legs and comprehensively reduce the possibility of muscle spasms. With the specific angle design between the cams 41, the continuity and efficiency of mouse muscle relaxation are guaranteed, so that the mouse muscles are always in a relaxed state, the stability of the testicles is guaranteed, and the stability and success rate of the experimental operation are greatly improved.

[0026] As a further configuration of this embodiment, a restraint slot 23 is provided on the restraint chamber 2, and a positioning hole is provided on the base 1 at a position corresponding to the restraint slot 23. A restraint buckle 5 is provided in the restraint slot 23. The restraint buckle 5 includes a gripping portion 53, a buckle pressing portion 52, and a matching portion 51. The matching portion 51 is plugged and matched with the positioning hole to fix the restraint buckle 5 in the restraint slot 23. The buckle pressing portion is arranged in an arc shape, and the gripping portion 53 is exposed outside the restraint slot 23. The beneficial effect of such a configuration is that the restraint buckle 5 has a delicate structure, and is composed of the gripping portion 53, the buckle pressing portion 52, and the matching portion 51. When the operator places the mouse in the restraint chamber 2, the gripping portion 53 exposed outside the restraint slot 23 can be easily held by the operator, and the restraint buckle 5 can be inserted along the restraint slot 23. At this time, the matching portion 51 is accurately plugged and matched with the positioning hole, and the restraint buckle 5 is quickly firmly fixed in the restraint slot 23. The buckle part is set in an arc shape. This design fits the physiological curve of the mouse's neck. During the fixation process, it can effectively limit the range of motion of the mouse's neck without causing excessive pressure on the mouse, ensuring the stable position of the mouse. By accurately limiting the mouse's neck, the position deviation caused by the mouse's body twisting can be greatly reduced, effectively ensuring the position stability of the mouse during the entire testicular extraction operation. This not only provides the operator with a stable operating object, reduces the operational interference caused by the change of the mouse's position, but also helps to improve the accuracy and success rate of experimental operations.

[0027] As a further configuration of this embodiment, the buckle portion 52 is elastically configured. The beneficial effect of such a configuration is that the elastically configured buckle portion 52 can automatically adjust the degree of fit according to the actual thickness of the mouse's neck. For mice with thinner necks, the buckle portion 52 will be appropriately tightened under the action of elasticity to ensure effective positioning; and for mice with slightly thicker necks, the buckle portion 52 can be elastically expanded to avoid excessive compression. This adaptive characteristic not only allows the restraint buckle 5 to be suitable for mice of all sizes.

[0028] As a further configuration of this embodiment, the limiter 14 is elastically configured, one end of the limiter 14 is connected to the base 1, and the other end is bent to form a crank arm, and a limiter groove for engaging with the crank arm is provided on the side wall of the base 1. The beneficial effect of such configuration is that the limiter 14 is configured in such a way that after placing the mouse on the base 1, the limiter 14 is swung so that the limiter 14 abuts against the lower limbs of the mouse, and then the crank arm of the limiter 14 is clamped in the limiter groove, thereby forming a pressure limit. This structure is simple, can be effectively fixed, and has a good use effect.

[0029] The above example is only one preferred specific example of the present invention. Common changes and substitutions made by those skilled in the art within the scope of the technical solution of the present invention are all included in the protection scope of the present invention.

Claims

1. An auxiliary tool for extracting mouse testicles, comprising a base, characterized in that: A conical restraint cavity is provided at the end of the base, a limiting piece for fastening the lower limbs of a mouse is provided on the base, retaining walls are provided on both sides of the base, a support beam is extended from one end of the restraint cavity opening to between the two retaining walls, two hinged comb arms are provided on the support beam, comb teeth for scraping hair are provided at one end of the comb arm, a driving part is provided at the other end of the comb arm, an adsorption plate is also provided on the retaining wall, and the adsorption plate is connected to an electrostatic generator for making the adsorption plate carry static electricity.

2. The auxiliary tool for extracting mouse testicles according to claim 1, characterized in that: A connecting ball head is rotatably arranged on the support beam, a hinge column is arranged on the connecting ball head, and two comb arms are cross-arranged and rotatably connected to the hinge shaft respectively.

3. The auxiliary tool for extracting mouse testicles according to claim 2, characterized in that: A support spring for keeping the comb arms open is arranged between the comb arms, and a positioning pin is arranged on the comb arm at a position corresponding to the support spring, and the support spring is sleeved on the positioning pin.

4. The auxiliary tool for extracting mouse testicles according to claim 1, 2 or 3, characterized in that: An adjustment groove is arranged on the base along the length direction, an adjustment seat is slidably arranged in the adjustment groove, a driving wheel and a driving motor for driving the driving wheel to rotate are arranged on the adjustment seat, the driving wheel includes a connecting shaft and two cams, and the cams are connected to the connecting shaft.

5. The auxiliary tool for extracting mouse testicles according to claim 4, characterized in that: The included angle formed by the projections of the two cam protruding ends on the plane where the retaining wall is located is 137-153°.

6. The auxiliary tool for extracting mouse testicles according to claim 5, characterized in that: A restraining slot is provided on the restraining cavity, a positioning hole is provided on the base corresponding to the position of the restraining slot, a restraining buckle is provided in the restraining slot, the restraining buckle includes a holding portion, a pressing portion and a matching portion, the matching portion is plugged into and matched with the positioning hole to fix the restraining buckle in the restraining slot, the pressing portion is arranged in an arc shape, and the holding portion is exposed outside the restraining slot.

7. The auxiliary tool for extracting mouse testicles according to claim 6, characterized in that: The buckle portion is elastically arranged.

8. The auxiliary tool for extracting mouse testicles according to claim 1, characterized in that: The limiting member is elastically arranged, one end of the limiting member is connected to the base, and the other end is bent to form a crank arm, and a limiting groove for clamping with the crank arm is arranged on the side wall of the base.

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