BFS sterile skin moistening oil for children as well as preparation method and application of BFS sterile skin moistening oil

Abstract

The invention relates to the technical field of skin moistening oil, and particularly discloses BFS sterile skin moistening oil for children as well as a preparation method and application thereof.The BFS sterile skin moistening oil is prepared from the following raw materials in parts by weight: 68-72 parts of sunflower seed oil, 18-22 parts of caprylic / capric triglyceride, 4-6 parts of simmondsia chinensis seed oil, 2-3 parts of coconut oil, 2-3 parts of pomegranate seed oil, 0.4-0.6 part of vitamin E, 0.07-0.09 part of squalane, 0.04-0.05 part of ceramide AP, 0.03-0.04 part of ceramide NP and 0.01-0.03 part of cholesterol. According to the skin moistening oil for children, the sunflower seed oil is matched with the simmondsia chinensis seed oil, the caprylic / capric triglyceride, the coconut oil, the pomegranate seed oil, the vitamin E and other raw materials to be blended and matched, meanwhile, the moisturizing effect and the sunscreen effect are remarkable, and balanced improvement of the performance of the product is achieved.

Description

Technical Field

[0001] The invention relates to the technical field of skin moisturizing oils, and in particular to a BFS sterile children's skin moisturizing oil and a preparation method and application thereof. Background Art

[0002] BFS technology is an integrated blowing, filling and sealing technology in the medical field, and is applied to disposable products in the cosmetic field. BFS technology completes the molding of containers, the filling of solutions and the sealing of containers on the same device, and can prepare children's moisturizing oil in an integrated operation. However, the existing children's moisturizing oil has no obvious improvement effect on the treatment of atopic dermatitis, and has poor moisturizing and sun protection effects. It is difficult for the product to achieve a balanced improvement in performance, and the product has poor stability under hot-cold and humid conditions, which affects the use efficiency of the product. Based on this, the present invention further improves it. Summary of the invention

[0003] In view of the defects of the prior art, the purpose of the present invention is to provide a BFS sterile children's moisturizing oil and a preparation method and application thereof, so as to solve the problems raised in the above background technology.

[0004] The present invention solves the technical problem by adopting the following technical solution: The present invention provides a BFS sterile children's moisturizing oil, comprising the following raw materials in parts by weight: 68-72 parts of sunflower seed oil, 18-22 parts of caprylic / capric triglyceride, 4-6 parts of jojoba seed oil, 2-3 parts of coconut oil, 2-3 parts of pomegranate seed oil, 0.4-0.6 parts of vitamin E, 0.07-0.09 parts of squalane, 0.04-0.05 parts of ceramide AP, 0.03-0.04 parts of ceramide NP, and 0.01-0.03 parts of cholesterol.

[0005] Preferably, the BFS sterile children's moisturizing oil comprises the following raw materials in parts by weight: 70 parts of sunflower seed oil, 20 parts of caprylic / capric triglyceride, 5 parts of jojoba seed oil, 2.5 parts of coconut oil, 2.5 parts of pomegranate seed oil, 0.5 parts of vitamin E, 0.08 parts of squalane, 0.045 parts of ceramide AP, 0.035 parts of ceramide NP, and 0.02 parts of cholesterol.

[0006] Preferably, the children's skin care oil further comprises 7 to 11 parts of an enhancer and 4 to 7 parts of a modifying additive; The preparation method of the enhancer is: S01: 4-7 parts of mesoporous silica, 2-4 parts of shell powder and 1-2 parts of calcium stearate are added to 6-10 parts of 5% sodium citrate solution, and then 2-3 parts of silane coupling agent KH550 are added to obtain a mesoporous silica / shell composite liquid; S02: Preparation of modified solution: S021: Add 2-4 parts of corn starch to 5-8 parts of 8% sodium lignin sulfonate solution, then add 1-2 parts of silane coupling agent KH560 and 2-3 parts of silica powder, and stir evenly to obtain the first modified solution; S022: 4 to 6 parts of nano zinc oxide, 1 to 3 parts of sodium silicate solution and 3 to 5 parts of dopamine hydrochloride solution are mixed evenly to obtain a second modified solution; Then, the first modified liquid and the second modified liquid are further mixed and stirred at a weight ratio of 5:3 to obtain a modified liquid; S03: heat-treat kaolin at 145-150°C for 15-20 min, then heat to 60°C at a rate of 1-3°C / min, and keep warm for 10 min; The insulated kaolin and the modified liquid are stirred and modified in a weight ratio of 2:5, and after the stirring is completed, the modified kaolin is filtered and dried to obtain the modified kaolin; S04: The modified kaolin and mesoporous silica / shell composite liquid are mixed in a weight ratio of 5:3 and ball-milled at a speed of 1000 r / min for 1 h. After the ball-milling is completed, the mixture is filtered and dried to obtain a reinforcing agent.

[0007] Preferably, the pore size of the mesoporous silica is 4 to 8 nm; the outer diameter is 50 to 150 nm; the stirring speed of the stirring modification treatment in S03 is 550 to 650 r / min, and the stirring is performed for 45 to 55 minutes.

[0008] Preferably, the mass fraction of the sodium silicate solution is 2-5%; the mass fraction of the dopamine hydrochloride solution is 4-7%.

[0009] Preferably, the preparation method of the modified additive is: S101: stirring the halloysite nanotubes in a sufficient amount of potassium permanganate solution, then washing, filtering, and drying, and then preheating the dried halloysite nanotubes at 65-70° C. for 1 hour to obtain pre-improved halloysite nanotubes; S102: ultrasonically treating the pre-modified halloysite nanotubes and the additive liquid in a weight ratio of 2:5. After the ultrasonic treatment is finished, the modified additive is filtered and dried to obtain a modified additive.

[0010] Preferably, the ultrasonic power of the ultrasonic treatment is 450-500W, and the ultrasonic time is 1-2h.

[0011] Preferably, the additive solution comprises the following raw materials in parts by weight: 2 to 5 parts of boron nitride, 1 to 3 parts of nano titanium dioxide, 4 to 7 parts of sodium alginate solution, 1 to 2 parts of sodium carboxymethyl cellulose and 2 to 4 parts of urea solution.

[0012] Preferably, the mass fraction of the sodium alginate solution is 2-5%; the mass fraction of the urea solution is 3-4%.

[0013] The present invention also provides a method for preparing BFS sterile children's moisturizing oil, comprising the following steps: Step 1: Add 45 parts of sunflower seed oil, 9 parts of caprylic / capric triglyceride, 5 parts of jojoba seed oil, 2.5 parts of coconut oil, 2.5 parts of pomegranate seed oil, 0.5 parts of vitamin E and 0.08 parts of squalane into the liquid preparation tank, set the speed to 60-100 r / min, the rated frequency of magnetic stirring to 1400 rpm, control the solution temperature at 20°C-40°C, and stir and dissolve for 10 minutes; Step 2: Then add 0.02 parts of cholesterol, and after the addition is completed, stir and dissolve for 2 hours until it is completely dissolved to obtain the first solution; Step 3: Add the remaining sunflower seed oil and the remaining caprylic / capric triglyceride into a beaker, control the water bath temperature to 80°C-90°C, add 0.045 parts of ceramide AP and 0.035 parts of ceramide NP into the beaker, and after the addition is completed, stir and dissolve for 2 hours until completely dissolved to obtain a second solution; Step 4: Add the second solution to the first solution, then add 7 to 11 parts of the enhancer and 4 to 7 parts of the modifying additive, maintain the rotation speed and temperature, continue stirring for 30 minutes, transfer to a storage tank, and then fill and seal the container to obtain the BFS sterile children's moisturizing oil of the present invention.

[0014] The above-mentioned BFS sterile children's moisturizing oil also has application in preventing mosquito bites.

[0015] Sunflower seed oil: Main effects: protecting cardiovascular system, protecting eyesight, beautifying and nourishing the skin, etc. It is rich in linoleic acid, which has anti-inflammatory and repairing effects. Although it has no direct mosquito repellent effect, it can enhance the skin barrier and reduce the inflammatory response after mosquito bites.

[0016] Caprylic / capric triglyceride: Main functions: moisturizing and lubricating; it is often used as a moisturizer in cosmetics and skin care products.

[0017] Jojoba seed oil: Main effects: moisturizing, anti-aging, cleansing and removing blackheads; Jojoba seed oil has excellent moisturizing properties, and can penetrate deep into the skin pores to clean dirt and oil, helping to prevent the formation of blackheads. It also has the effect of soothing skin redness and swelling, and its structure is similar to skin sebum, forming a protective film that can physically block mosquitoes from contacting the skin.

[0018] Coconut oil: Main effects: stress relief, skin care, hair care, weight loss, etc.; coconut oil has a skin care effect and is suitable for dry skin and peeling problems caused by various reasons. It can also delay wrinkles, sagging skin and other problems that gradually become prominent with age. It also contains lauric acid, and some studies have shown that it has a slight repellent effect on certain insects.

[0019] Pomegranate seed oil: Main effects: moisturizing the skin, improving antioxidant capacity, protecting the cardiovascular system, etc. Pomegranate seed oil is rich in punicic acid, which has a strong antioxidant capacity, can effectively remove free radicals and provide a strong protective barrier for the skin. At the same time, it also has anti-inflammatory and astringent effects, which can help relieve minor skin allergies and various inflammatory problems. Therefore, pomegranate seed oil may have a certain effect on relieving the redness and swelling after mosquito bites, but it is not its main effect.

[0020] Vitamin E: Main functions: anti-oxidation, improving reproductive function, protecting cardiovascular health, etc.

[0021] Vitamin E removes free radicals from the body, protects cells from damage, and helps slow the aging process.

[0022] Squalane: Squalane is a hydrocarbon oil with excellent stability and penetration, and is often used as a moisturizing ingredient in skin care products.

[0023] Ceramide AP, Ceramide NP: Ceramide is an important component of the skin barrier and has the effects of moisturizing, repairing the skin barrier, and enhancing skin defense.

[0024] Cholesterol: Cholesterol is one of the lipid components on the surface of the skin and plays a certain role in maintaining the normal function and barrier function of the skin.

[0025] Compared with the prior art, the present invention has the following beneficial effects: The children's moisturizing oil of the present invention adopts sunflower seed oil, jojoba seed oil, caprylic acid / capric acid triglyceride, coconut oil, pomegranate seed oil, vitamin E and other raw materials for blending and coordination, and the added enhancer and modifying additive are coordinated and coordinated, and the product has obvious improvement effect on the treatment of atopic dermatitis, and at the same time, the moisturizing effect and the sunscreen effect are significant, the product realizes balanced improvement of performance, and the product has significant stability effect under hot-cold and humid conditions; The reinforcing agent adopts kaolin to be heat-treated at 145-150°C for 15-20min, and then the temperature is raised to 60°C at a rate of 1-3°C / min, and the temperature is kept for 10min. Through the heat improvement treatment, the activity efficiency of kaolin is optimized, and the interlayer spacing of the product is improved. At the same time, the modified liquid is stirred and improved. The first modified liquid and the second modified liquid in the modified liquid are mutually coordinated. The first modified liquid is adjusted by corn starch through 8% sodium lignin sulfonate solution by mass fraction, and then the silane coupling agent KH560 and silica powder are coordinated. Then, nano zinc oxide, sodium silicate solution and dopamine hydrochloride solution are uniformly blended to obtain the second modified liquid. The silica powder in the first modified liquid is adjusted with corn starch and other raw materials, and then nano zinc oxide and other raw materials in the second modified liquid are coordinated. The raw materials are coordinated with each other to form a modified liquid together, thereby optimizing the synergistic effect of kaolin and mesoporous silica / shell composite liquid, and further improving the performance of the product. The mesoporous silica / shell composite liquid adopts mesoporous silica and shell powder to mix the calcium stearate of the present invention, 5% by mass sodium citrate solution and other raw materials, and uses a high surface area, porous silica structure to carry the shell powder, and then is blended and coordinated with kaolin with a lamellar structure to optimize the moisturizing effect and sunscreen effect of the product, while improving the atopic dermatitis treatment effect of the product, and further optimize the stability effect of the product under hot-cold and humid conditions; The modified additive adopts halloysite nanotubes treated with potassium permanganate solution to optimize its active efficiency, and at the same time, halloysite nanotubes with high specific surface area are formulated into the system to enhance the synergistic effect between the raw materials, and at the same time, additive liquid is used for synergistic improvement, and the boron nitride, nano titanium dioxide, sodium alginate solution, sodium carboxymethyl cellulose and urea solution in the additive liquid are blended and improved, and the nano titanium dioxide is blended and improved with boron nitride, and then synergized and optimized with sodium alginate solution, sodium carboxymethyl cellulose and urea solution. The obtained additive liquid can better synergize and improve the modified additive, so that the modified additive and the enhancer can be better synergized, and the two are reinforced and improved, so that the product has obvious improvement effect on the treatment of atopic dermatitis, and the moisturizing and sunscreen effects achieve balanced improvement of performance, and the product has significant stability effect under hot-cold and humid conditions. DETAILED DESCRIPTION

[0026] The following is a clear and complete description of the technical solutions in the embodiments of the present invention in conjunction with specific embodiments. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0027] A BFS sterile children's moisturizing oil in this embodiment includes the following raw materials in parts by weight: 68-72 parts of sunflower seed oil, 18-22 parts of caprylic / capric triglyceride, 4-6 parts of jojoba seed oil, 2-3 parts of coconut oil, 2-3 parts of pomegranate seed oil, 0.4-0.6 parts of vitamin E, 0.07-0.09 parts of squalane, 0.04-0.05 parts of ceramide AP, 0.03-0.04 parts of ceramide NP, and 0.01-0.03 parts of cholesterol.

[0028] The BFS sterile children's moisturizing oil of this embodiment comprises the following raw materials in parts by weight: 70 parts of sunflower seed oil, 20 parts of caprylic / capric triglyceride, 5 parts of jojoba seed oil, 2.5 parts of coconut oil, 2.5 parts of pomegranate seed oil, 0.5 parts of vitamin E, 0.08 parts of squalane, 0.045 parts of ceramide AP, 0.035 parts of ceramide NP, and 0.02 parts of cholesterol.

[0029] The children's skin care oil of this embodiment also includes 7 to 11 parts of an enhancer and 4 to 7 parts of a modifying additive; The preparation method of the enhancer is: S01: 4-7 parts of mesoporous silica, 2-4 parts of shell powder and 1-2 parts of calcium stearate are added to 6-10 parts of 5% sodium citrate solution, and then 2-3 parts of silane coupling agent KH550 are added to obtain a mesoporous silica / shell composite liquid; S02: Preparation of modified solution: S021: Add 2-4 parts of corn starch to 5-8 parts of 8% sodium lignin sulfonate solution, then add 1-2 parts of silane coupling agent KH560 and 2-3 parts of silica powder, and stir evenly to obtain the first modified solution; S022: 4 to 6 parts of nano zinc oxide, 1 to 3 parts of sodium silicate solution and 3 to 5 parts of dopamine hydrochloride solution are mixed evenly to obtain a second modified solution; Then, the first modified liquid and the second modified liquid are further mixed and stirred at a weight ratio of 5:3 to obtain a modified liquid; S03: heat-treat kaolin at 145-150°C for 15-20 min, then heat to 60°C at a rate of 1-3°C / min, and keep warm for 10 min; The insulated kaolin and the modified liquid are stirred and modified in a weight ratio of 2:5, and after the stirring is completed, the modified kaolin is filtered and dried to obtain the modified kaolin; S04: The modified kaolin and mesoporous silica / shell composite liquid are mixed in a weight ratio of 5:3 and ball-milled at a speed of 1000 r / min for 1 h. After the ball-milling is completed, the mixture is filtered and dried to obtain a reinforcing agent.

[0030] The pore size of the mesoporous silica in this embodiment is 4-8 nm; the outer diameter is 50-150 nm; the stirring speed of the stirring modification treatment in S03 is 550-650 r / min, and the stirring is performed for 45-55 min.

[0031] The mass fraction of the sodium silicate solution in this embodiment is 2-5%; the mass fraction of the dopamine hydrochloride solution is 4-7%.

[0032] The preparation method of the modified additive of this embodiment is: S101: stirring the halloysite nanotubes in a sufficient amount of potassium permanganate solution, then washing, filtering, and drying, and then preheating the dried halloysite nanotubes at 65-70° C. for 1 hour to obtain pre-improved halloysite nanotubes; S102: ultrasonically treating the pre-modified halloysite nanotubes and the additive liquid in a weight ratio of 2:5. After the ultrasonic treatment is finished, the modified additive is filtered and dried to obtain a modified additive.

[0033] The ultrasonic power of the ultrasonic treatment in this embodiment is 450-500W, and the ultrasonic time is 1-2h.

[0034] The additive solution of this embodiment includes the following raw materials in parts by weight: 2 to 5 parts of boron nitride, 1 to 3 parts of nano titanium dioxide, 4 to 7 parts of sodium alginate solution, 1 to 2 parts of sodium carboxymethyl cellulose and 2 to 4 parts of urea solution.

[0035] The mass fraction of the sodium alginate solution in this embodiment is 2-5%; the mass fraction of the urea solution is 3-4%.

[0036] The preparation method of the BFS sterile children's moisturizing oil of this embodiment comprises the following steps: Step 1: Add 45 parts of sunflower seed oil, 9 parts of caprylic / capric triglyceride, 5 parts of jojoba seed oil, 2.5 parts of coconut oil, 2.5 parts of pomegranate seed oil, 0.5 parts of vitamin E and 0.08 parts of squalane into the liquid preparation tank, set the speed to 60-100 r / min, the rated frequency of magnetic stirring to 1400 rpm, control the solution temperature at 20°C-40°C, and stir and dissolve for 10 minutes; Step 2: Then add 0.02 parts of cholesterol, and after the addition is completed, stir and dissolve for 2 hours until it is completely dissolved to obtain the first solution; Step 3: Add the remaining sunflower seed oil and the remaining caprylic / capric triglyceride into a beaker, control the water bath temperature to 80°C-90°C, add 0.045 parts of ceramide AP and 0.035 parts of ceramide NP into the beaker, and after the addition is completed, stir and dissolve for 2 hours until completely dissolved to obtain a second solution; Step 4: Add the second solution to the first solution, then add 7 to 11 parts of the enhancer and 4 to 7 parts of the modifying additive, maintain the rotation speed and temperature, continue stirring for 30 minutes, transfer to a storage tank, and then fill and seal the container to obtain the BFS sterile children's moisturizing oil of the present invention.

[0037] Example 1. A BFS sterile children's moisturizing oil in this embodiment includes the following raw materials in parts by weight: 68 parts of sunflower seed oil, 18 parts of caprylic / capric triglyceride, 4 parts of jojoba seed oil, 2 parts of coconut oil, 2 parts of pomegranate seed oil, 0.4 parts of vitamin E, 0.07 parts of squalane, 0.04 parts of ceramide AP, 0.03 parts of ceramide NP, and 0.01 parts of cholesterol.

[0038] The children's skin care oil of this embodiment also includes 7 parts of enhancer and 4 parts of modifying additive; The preparation process of the enhancer is: S01: 4 parts of mesoporous silica, 2 parts of shell powder and 1 part of calcium stearate are added to 6 parts of 5% sodium citrate solution, and then 2 parts of silane coupling agent KH550 are added to obtain a mesoporous silica / shell composite liquid; S02: Preparation of modified solution: S021: Add 2 parts of corn starch to 5 parts of 8% sodium lignin sulfonate solution, then add 1 part of silane coupling agent KH560 and 2 parts of silica powder, and stir evenly to obtain the first modified solution; S022: 4 parts of nano zinc oxide, 1 part of sodium silicate solution and 3 parts of dopamine hydrochloride solution are mixed evenly to obtain a second modified solution; Then, the first modified liquid and the second modified liquid are further mixed and stirred at a weight ratio of 5:3 to obtain a modified liquid; S03: heat-treat kaolin at 145°C for 15 min, then heat to 60°C at a rate of 1°C / min and keep at this temperature for 10 min; The insulated kaolin and the modified liquid are stirred and modified in a weight ratio of 2:5, and after the stirring is completed, the modified kaolin is filtered and dried to obtain the modified kaolin; S04: The modified kaolin and mesoporous silica / shell composite liquid are mixed in a weight ratio of 5:3 and ball-milled at a speed of 1000 r / min for 1 h. After the ball-milling is completed, the mixture is filtered and dried to obtain a reinforcing agent.

[0039] The pore size of the mesoporous silica in this embodiment is 4 nm; the outer diameter is 50 nm; the stirring speed of the stirring modification treatment in S03 is 550 r / min, and the stirring is performed for 45 min.

[0040] The mass fraction of the sodium silicate solution in this embodiment is 2%; the mass fraction of the dopamine hydrochloride solution is 4%.

[0041] The preparation process of the modified additive of this embodiment is: S101: stirring the halloysite nanotubes in a sufficient amount of potassium permanganate solution, then washing, filtering, and drying, and then preheating the dried halloysite nanotubes at 65° C. for 1 h to obtain pre-improved halloysite nanotubes; S102: ultrasonically treating the pre-modified halloysite nanotubes and the additive liquid in a weight ratio of 2:5. After the ultrasonic treatment is finished, the modified additive is filtered and dried to obtain a modified additive.

[0042] The ultrasonic power of the ultrasonic treatment in this embodiment is 450W, and the ultrasonic time is 1 hour.

[0043] The additive solution of this embodiment includes the following raw materials in parts by weight: 2 parts of boron nitride, 1 part of nano titanium dioxide, 4 parts of sodium alginate solution, 1 part of sodium carboxymethyl cellulose and 2 parts of urea solution.

[0044] The mass fraction of the sodium alginate solution in this embodiment is 2%; the mass fraction of the urea solution is 3%.

[0045] The preparation method of the BFS sterile children's moisturizing oil of this embodiment comprises the following steps: Step 1: Add 45 parts of sunflower seed oil, 9 parts of caprylic / capric triglyceride, 5 parts of jojoba seed oil, 2.5 parts of coconut oil, 2.5 parts of pomegranate seed oil, 0.5 parts of vitamin E and 0.08 parts of squalane into the liquid preparation tank, set the speed to 60r / min, the rated frequency of magnetic stirring to 1400 rpm, control the solution temperature at 20°C, and stir and dissolve for 10 minutes; Step 2: Then add 0.02 parts of cholesterol, and after the addition is completed, stir and dissolve for 2 hours until it is completely dissolved to obtain the first solution; Step 3: Add the remaining sunflower seed oil and the remaining caprylic / capric triglyceride into a beaker, control the water bath temperature to 80°C, add 0.045 parts of ceramide AP and 0.035 parts of ceramide NP into the beaker, and after the addition is completed, stir and dissolve for 2 hours until completely dissolved to obtain a second solution; Step 4: Add the second solution to the first solution, then add 7 parts of enhancer and 4 parts of modifying additive, maintain the rotation speed and temperature, continue stirring for 30 minutes, transfer to the storage tank, and then fill and seal the container to obtain the BFS sterile children's moisturizing oil of the present invention.

[0046] Example 2. A BFS sterile children's moisturizing oil in this embodiment includes the following raw materials in parts by weight: 72 parts of sunflower seed oil, 22 parts of caprylic / capric triglyceride, 6 parts of jojoba seed oil, 3 parts of coconut oil, 3 parts of pomegranate seed oil, 0.6 parts of vitamin E, 0.09 parts of squalane, 0.05 parts of ceramide AP, 0.04 parts of ceramide NP, and 0.03 parts of cholesterol.

[0047] The children's skin care oil of this embodiment also includes 11 parts of reinforcing agent and 7 parts of modifying additive; The preparation method of the enhancer is: S01: 7 parts of mesoporous silica, 4 parts of shell powder and 2 parts of calcium stearate are added to 10 parts of 5% sodium citrate solution, and then 3 parts of silane coupling agent KH550 are added to obtain a mesoporous silica / shell composite liquid; S02: Preparation of modified solution: S021: adding 4 parts of corn starch to 8 parts of 8% sodium lignin sulfonate solution, and then adding 2 parts of silane coupling agent KH560 and 3 parts of silica powder, stirring evenly to obtain a first modified solution; S022: 6 parts of nano zinc oxide, 3 parts of sodium silicate solution and 5 parts of dopamine hydrochloride solution are mixed evenly to obtain a second modified solution; Then, the first modified liquid and the second modified liquid are further mixed and stirred at a weight ratio of 5:3 to obtain a modified liquid; S03: heat-treat kaolin at 150°C for 20 min, then heat to 60°C at a rate of 3°C / min and keep at this temperature for 10 min; The insulated kaolin and the modified liquid are stirred and modified in a weight ratio of 2:5, and after the stirring is completed, the modified kaolin is filtered and dried to obtain the modified kaolin; S04: The modified kaolin and mesoporous silica / shell composite liquid are mixed in a weight ratio of 5:3 and ball-milled at a speed of 1000 r / min for 1 h. After the ball-milling is completed, the mixture is filtered and dried to obtain a reinforcing agent.

[0048] The pore size of the mesoporous silica in this embodiment is 8 nm; the outer diameter is 150 nm; the stirring speed of the stirring modification treatment in S03 is 650 r / min, and the stirring is performed for 55 min.

[0049] The mass fraction of the sodium silicate solution in this embodiment is 5%; the mass fraction of the dopamine hydrochloride solution is 7%.

[0050] The preparation method of the modified additive of this embodiment is: S101: stirring the halloysite nanotubes in a sufficient amount of potassium permanganate solution, then washing, filtering, and drying, and then preheating the dried halloysite nanotubes at 70° C. for 1 h to obtain pre-improved halloysite nanotubes; S102: ultrasonically treating the pre-modified halloysite nanotubes and the additive liquid in a weight ratio of 2:5. After the ultrasonic treatment is finished, the modified additive is filtered and dried to obtain a modified additive.

[0051] The ultrasonic power of the ultrasonic treatment in this embodiment is 500W, and the ultrasonic time is 2h.

[0052] The additive solution of this embodiment includes the following raw materials in parts by weight: 5 parts of boron nitride, 3 parts of nano titanium dioxide, 7 parts of sodium alginate solution, 2 parts of sodium carboxymethyl cellulose and 4 parts of urea solution.

[0053] The mass fraction of the sodium alginate solution in this embodiment is 5%; the mass fraction of the urea solution is 4%.

[0054] The preparation method of a BFS sterile children's moisturizing oil in this embodiment comprises the following steps: Step 1: Add 45 parts of sunflower seed oil, 9 parts of caprylic / capric triglyceride, 5 parts of jojoba seed oil, 2.5 parts of coconut oil, 2.5 parts of pomegranate seed oil, 0.5 parts of vitamin E and 0.08 parts of squalane into the liquid preparation tank, set the speed to 100 r / min, the rated frequency of magnetic stirring to 1400 rpm, control the solution temperature to 40°C, and stir and dissolve for 10 minutes; Step 2: Then add 0.02 parts of cholesterol, and after the addition is completed, stir and dissolve for 2 hours until it is completely dissolved to obtain the first solution; Step 3: Add the remaining sunflower seed oil and the remaining caprylic / capric triglyceride into a beaker, control the water bath temperature to 90°C, add 0.045 parts of ceramide AP and 0.035 parts of ceramide NP into the beaker, and after the addition is completed, stir and dissolve for 2 hours until completely dissolved to obtain a second solution; Step 4: Add the second solution to the first solution, then add 11 parts of the enhancer and 7 parts of the modifying additive, maintain the rotation speed and temperature, continue stirring for 30 minutes, transfer to a storage tank, and then fill and seal the container to obtain the BFS sterile children's moisturizing oil of the present invention.

[0055] Example 3. A BFS sterile children's moisturizing oil in this embodiment includes the following raw materials in parts by weight: 70 parts of sunflower seed oil, 20 parts of caprylic / capric triglyceride, 5 parts of jojoba seed oil, 2.5 parts of coconut oil, 2.5 parts of pomegranate seed oil, 0.5 parts of vitamin E, 0.08 parts of squalane, 0.045 parts of ceramide AP, 0.035 parts of ceramide NP, and 0.02 parts of cholesterol.

[0056] The children's skin care oil of this embodiment also includes 9 parts of enhancer and 5.5 parts of modifying additive; The preparation method of the enhancer is: S01: 5.5 parts of mesoporous silica, 3 parts of shell powder and 1.5 parts of calcium stearate are added to 8 parts of 5% sodium citrate solution, and then 2.5 parts of silane coupling agent KH550 are added to obtain a mesoporous silica / shell composite liquid; S02: Preparation of modified solution: S021: Add 3 parts of corn starch to 6.5 parts of 8% sodium lignin sulfonate solution, then add 1.5 parts of silane coupling agent KH560 and 2.5 parts of silica powder, stir evenly to obtain a first modified solution; S022: 5 parts of nano zinc oxide, 2 parts of sodium silicate solution and 4 parts of dopamine hydrochloride solution are mixed evenly to obtain a second modified solution; Then, the first modified liquid and the second modified liquid are further mixed and stirred at a weight ratio of 5:3 to obtain a modified liquid; S03: heat-treat kaolin at 147.5°C for 17.5 min, then heat to 60°C at a rate of 2°C / min and keep at this temperature for 10 min; The insulated kaolin and the modified liquid are stirred and modified in a weight ratio of 2:5, and after the stirring is completed, the modified kaolin is filtered and dried to obtain the modified kaolin; S04: The modified kaolin and mesoporous silica / shell composite liquid are mixed in a weight ratio of 5:3 and ball-milled at a speed of 1000 r / min for 1 h. After the ball-milling is completed, the mixture is filtered and dried to obtain a reinforcing agent.

[0057] The pore size of the mesoporous silica in this embodiment is 6 nm; the outer diameter is 100 nm; the stirring speed of the stirring modification treatment in S03 is 600 r / min, and the stirring is for 50 min.

[0058] The mass fraction of the sodium silicate solution in this embodiment is 3.5%; the mass fraction of the dopamine hydrochloride solution is 5.5%.

[0059] The preparation method of the modified additive of this embodiment is: S101: stirring the halloysite nanotubes in a sufficient amount of potassium permanganate solution, then washing, filtering, and drying, and then preheating the dried halloysite nanotubes at 67.5° C. for 1 h to obtain pre-improved halloysite nanotubes; S102: ultrasonically treating the pre-modified halloysite nanotubes and the additive liquid in a weight ratio of 2:5. After the ultrasonic treatment is finished, the modified additive is filtered and dried to obtain a modified additive.

[0060] The ultrasonic power of the ultrasonic treatment in this embodiment is 475W, and the ultrasonic time is 1.5h.

[0061] The additive solution of this embodiment includes the following raw materials in parts by weight: 3.5 parts of boron nitride, 2 parts of nano titanium dioxide, 5.5 parts of sodium alginate solution, 1.5 parts of sodium carboxymethyl cellulose and 3 parts of urea solution.

[0062] The mass fraction of the sodium alginate solution in this embodiment is 3.5%; the mass fraction of the urea solution is 3.5%.

[0063] The preparation method of a BFS sterile children's moisturizing oil in this embodiment comprises the following steps: Step 1: Add 45 parts of sunflower seed oil, 9 parts of caprylic / capric triglyceride, 5 parts of jojoba seed oil, 2.5 parts of coconut oil, 2.5 parts of pomegranate seed oil, 0.5 parts of vitamin E and 0.08 parts of squalane into the liquid preparation tank, set the speed to 80r / min, the rated frequency of magnetic stirring to 1400 rpm, control the solution temperature to 30°C, and stir and dissolve for 10 minutes; Step 2: Then add 0.02 parts of cholesterol, and after the addition is completed, stir and dissolve for 2 hours until it is completely dissolved to obtain the first solution; Step 3: Add the remaining sunflower seed oil and the remaining caprylic / capric triglyceride into a beaker, control the water bath temperature to 85°C, add 0.045 parts of ceramide AP and 0.035 parts of ceramide NP into the beaker, and after the addition is completed, stir and dissolve for 2 hours until completely dissolved to obtain a second solution; Step 4: Add the second solution to the first solution, then add 9 parts of the enhancer and 5.5 parts of the modifying additive, maintain the rotation speed and temperature, continue stirring for 30 minutes, transfer to a storage tank, and then fill and seal the container to obtain the BFS sterile children's moisturizing oil of the present invention.

[0064] An application of the BFS sterile children's moisturizing oil as described above in preventing mosquito bites.

[0065] Comparative Example 1 The difference from Example 3 is that no reinforcing agent was added.

[0066] Comparative Example 2 The difference from Example 3 is that no modified kaolin is added into the reinforcing agent.

[0067] Comparative Example 3 The difference from Example 3 is that no modifying liquid is added in the preparation of the modified kaolin.

[0068] Comparative Example 4 The difference from Example 3 is that the first modifying liquid is not added to the modifying liquid.

[0069] Comparative Example 5 The difference from Example 3 is that no silane coupling agent KH560 and silica powder are added to the first modified liquid.

[0070] Comparative Example 6 The difference from Example 3 is that no second modifying liquid is added.

[0071] Comparative Example 7 The difference from Example 3 is that no nano zinc oxide or sodium silicate solution is added to the second modified solution.

[0072] Comparative Example 8 The difference from Example 3 is that the reinforcing agent is not treated with mesoporous silica / shell composite liquid.

[0073] Comparative Example 9 The difference from Example 3 is that no mesoporous silica or shell powder is added in the preparation of the mesoporous silica / shell composite liquid.

[0074] Comparative Example 10 The difference from Example 3 is that no modifying additive is added.

[0075] Comparative Example 11 The difference from Example 3 is that no pre-modified halloysite nanotubes are added to the modifying additive.

[0076] Comparative Example 12 The difference from Example 3 is that no additive liquid is added to the modified additive.

[0077] The products of Examples 1 to 3 and Comparative Examples 1 to 12 were subjected to performance tests to test the products for the treatment of atopic dermatitis. Children with atopic dermatitis aged 3-10 years old were studied, regardless of gender, and the test subjects were evenly divided into groups. The test subjects were smeared with the test products of Examples 1-3 and Comparative Examples 1-12, once every 2 days, once in the morning and once in the evening, one month as a course of treatment, and a total of 2 courses of treatment; Effective, the skin lesion area is reduced by 40-79%, the skin is slightly itchy, and there is no dryness; Cured, the skin lesion area is reduced by more than 80%, and there is no itching or dryness; Significantly effective, the skin lesion area is reduced by 5-39%, and the skin is slightly itchy; Ineffective, no significant changes; Total effective rate = (cured cases + effective cases + markedly effective cases) / total cases × 100%; relapse rate = (cases of aggravated condition) / total cases × 100%; The test results of moisturizing effect (apply the test product to the same part of the subject, use a skin moisture meter to test the skin moisture content, and test the moisturizing rate for 6 hours) and sun protection effect (SPF-290AS analyzer test) and product stability under hot-cold and humid conditions (place the product at 65℃ for 24 hours, then at 5℃ for 24 hours, and then at 10% humidity for 12 hours, the above is one cycle, and the cycle test is 10 times), are as follows;

[0078] It can be seen from Comparative Examples 1 to 12 and Examples 1 to 3 that; The product of Example 3 has an excellent moisturizing rate, and at the same time has excellent sunscreen effect and specific dermatitis healing performance, and the recurrence rate of the product is significantly improved; If the product does not contain any of the reinforcing agent or the modifying additive, the performance of the product will deteriorate significantly. The performance effect of the product will be most obvious if the two are used in combination. The performance of the products showed a trend of deterioration to varying degrees when no modified kaolin was added to the reinforcing agent, no modifying liquid was added in the preparation of the modified kaolin, no first modifying liquid was added to the modifying liquid, no silane coupling agent KH560 and silica powder were added to the first modifying liquid, no second modifying liquid was added, no nano zinc oxide and sodium silicate solution were added to the second modifying liquid, the reinforcing agent was not treated with mesoporous silica / shell composite liquid, and no mesoporous silica and shell powder were added in the preparation of the mesoporous silica / shell composite liquid. The modified kaolin improved by the modifying liquid prepared by combining the first modifying liquid and the second modifying liquid obtained by the specific method of the present invention, and the reinforcing agent prepared by combining the mesoporous silica / shell composite liquid obtained by the specific method of the present invention had the most significant product performance effect, and the effects of other methods were not as obvious as those of the present invention. When the pre-modified halloysite nanotubes and the additive liquid are not added to the modified additive, the performance of the product tends to deteriorate. The modified additive obtained by the specific method of the present invention has the most significant product performance effect. When the additive liquid is not added to the modified additive, the performance of the product deteriorates more significantly.

[0079] Based on the above tests, the present invention further explores the product performance by adding liquid; Experimental Example 1 The same as Example 3, except that no boron nitride is added to the additive solution.

[0080] Experimental Example 2 The same as Example 3, the only difference is that no nano titanium dioxide is added to the additive solution.

[0081] Experimental Example 3 The same as Example 3, the only difference is that no sodium alginate solution is added to the additive solution.

[0082] Experimental Example 4 The same as Example 3, the only difference is that no urea solution is added to the additive liquid.

[0083] Experimental Example 5 The same as Example 3, the only difference is that sodium carboxymethyl cellulose is not added to the additive solution.

[0084] Continue to test the performance of Experimental Examples 1-5, the test is as follows:

[0085] It can be seen from Experimental Examples 1-5 that when no boron nitride or nano titanium dioxide is added to the additive liquid, the performance of the product has a relatively obvious trend of deterioration. At the same time, when no sodium alginate solution, no urea solution or sodium carboxymethyl cellulose is added to the additive liquid, the performance of the product has a trend of deterioration. The additive liquid obtained by the specific method of the present invention has the most obvious performance effect of the product, and other methods are not as significant as the effect of the present invention.

[0086] Based on the above test, the present invention explores the mosquito repellent performance of the product through test examples: Test Example 1 Same as Example 3, except that no sunflower seed oil is added to the formula.

[0087] Test Example 2 The same as Example 3, the only difference is that jojoba oil is not added in the formula.

[0088] Test Example 3 Same as Example 3, except that coconut oil is not added in the formula.

[0089] Test Example 4 The same as Example 3, the only difference is that pomegranate seed oil is not added in the formula.

[0090] Test Example 5 The same as Example 3, except that ceramide AP is not added to the formula.

[0091] Test Example 6 Same as Example 3, except that ceramide NP is not added to the formula.

[0092] Test Example 7 Same as Example 3, except that cholesterol is not added to the formula.

[0093] Test conditions: Apply the same amount of product on the arm, and put the hand into a sealed box and keep it still. There are 50 mosquitoes of the same batch and the same time that have not sucked blood in the sealed box. When a mosquito lands on the arm, it is counted as a bite. Observe for 5 minutes. Then pull out the arm (without washing), and put it into the sealed box again after 2 hours to keep it still. Observe for 5 minutes and record the data; then pull out the arm again (without washing), and put it into the sealed box again after 2 hours to keep it still. Observe for 5 minutes and record the data. The specific experimental results are shown in the following table:

[0094] From test examples 1-7, if the corresponding ratio is not added to the product, the effect of preventing mosquito bites has a more obvious deterioration trend; the performance effect of the product of the present invention is the most obvious, and the effect of other products is not as significant as that of the present invention.

[0095] Sunflower seed oil: Rich in linoleic acid, it has anti-inflammatory and repairing effects. Although it has no direct mosquito repellent effect, it can strengthen the skin barrier and reduce the inflammatory response after mosquito bites.

[0096] Jojoba seed oil: Its structure is similar to skin sebum, forming a protective film that may physically block mosquitoes from contacting the skin.

[0097] Coconut oil: It contains lauric acid, which some studies have shown to have a mild repellent effect on certain insects.

[0098] Pomegranate seed oil: It has anti-inflammatory and astringent effects, which can help relieve minor skin allergies and various inflammatory problems. Therefore, pomegranate seed oil may have a certain effect on relieving the redness and swelling after mosquito bites, but it is not its main effect.

[0099] Ceramide, Squalane and Cholesterol: Repair the skin barrier and reduce the attraction of mosquitoes caused by damaged skin (such as sweat and sebum secretion).

[0100] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the present invention can be implemented in other specific forms without departing from the spirit or essential features of the present invention. Therefore, the embodiments should be considered exemplary and non-restrictive in all respects, and the scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims be included in the present invention.

[0101] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A BFS sterile children's moisturizing oil, characterized in that: It includes the following raw materials in parts by weight: 68-72 parts of sunflower seed oil, 18-22 parts of caprylic / capric triglyceride, 4-6 parts of jojoba seed oil, 2-3 parts of coconut oil, 2-3 parts of pomegranate seed oil, 0.4-0.6 parts of vitamin E, 0.07-0.09 parts of squalane, 0.04-0.05 parts of ceramide AP, 0.03-0.04 parts of ceramide NP, 0.01-0.03 parts of cholesterol; The children's skin care oil also includes 7 to 11 parts of an enhancer and 4 to 7 parts of a modifying additive; The preparation process of the enhancer is: S01: 4-7 parts of mesoporous silica, 2-4 parts of shell powder and 1-2 parts of calcium stearate are added to 6-10 parts of 5% sodium citrate solution, and then 2-3 parts of silane coupling agent KH550 are added to obtain a mesoporous silica / shell composite liquid; S02: Preparation of modified solution: S021: Add 2-4 parts of corn starch to 5-8 parts of 8% sodium lignin sulfonate solution, then add 1-2 parts of silane coupling agent KH560 and 2-3 parts of silica powder, and stir evenly to obtain the first modified solution; S022: 4 to 6 parts of nano zinc oxide, 1 to 3 parts of sodium silicate solution and 3 to 5 parts of dopamine hydrochloride solution are mixed evenly to obtain a second modified solution; Then, the first modified liquid and the second modified liquid are further mixed and stirred at a weight ratio of 5:3 to obtain a modified liquid; S03: heat-treat kaolin at 145-150°C for 15-20 min, then heat to 60°C at a rate of 1-3°C / min, and keep warm for 10 min; The insulated kaolin and the modified liquid are stirred and modified in a weight ratio of 2:5, and after the stirring is completed, the modified kaolin is filtered and dried to obtain the modified kaolin; S04: The modified kaolin and mesoporous silica / shell composite liquid are mixed in a weight ratio of 5:3 and ball-milled at a speed of 1000 r / min for 1 h. After the ball-milling is completed, the mixture is filtered and dried to obtain a reinforcing agent.

2. The BFS sterile children's moisturizing oil according to claim 1, characterized in that: The BFS sterile children's moisturizing oil comprises the following raw materials in parts by weight: 70 parts of sunflower seed oil, 20 parts of caprylic / capric triglyceride, 5 parts of jojoba seed oil, 2.5 parts of coconut oil, 2.5 parts of pomegranate seed oil, 0.5 parts of vitamin E, 0.08 parts of squalane, 0.045 parts of ceramide AP, 0.035 parts of ceramide NP, and 0.02 parts of cholesterol.

3. The BFS sterile children's moisturizing oil according to claim 1, characterized in that The pore size of the mesoporous silica is 4 to 8 nm; the outer diameter is 50 to 150 nm; the stirring speed of the stirring modification treatment in S03 is 550 to 650 r / min, and the stirring is 45 to 55 min; The mass fraction of the sodium silicate solution is 2-5%; the mass fraction of the dopamine hydrochloride solution is 4-7%.

4. The BFS sterile children's moisturizing oil according to claim 1, characterized in that: The preparation process of the modified additive is: S101: stirring the halloysite nanotubes in a sufficient amount of potassium permanganate solution, then washing, filtering, and drying, and then preheating the dried halloysite nanotubes at 65-70° C. for 1 hour to obtain pre-improved halloysite nanotubes; S102: ultrasonically treating the pre-modified halloysite nanotubes and the additive liquid in a weight ratio of 2:

5. After the ultrasonic treatment is finished, the modified additive is filtered and dried to obtain a modified additive.

5. The BFS sterile children's moisturizing oil according to claim 4, characterized in that: The ultrasonic power of the ultrasonic treatment is 450-500W, and the ultrasonic time is 1-2h.

6. The BFS sterile children's moisturizing oil according to claim 4, characterized in that: The additive solution includes the following raw materials in parts by weight: 2 to 5 parts of boron nitride, 1 to 3 parts of nano titanium dioxide, 4 to 7 parts of sodium alginate solution, 1 to 2 parts of sodium carboxymethyl cellulose and 2 to 4 parts of urea solution.

7. The BFS sterile children's moisturizing oil according to claim 6, characterized in that: The mass fraction of the sodium alginate solution is 2-5%; the mass fraction of the urea solution is 3-4%.

8. A method for preparing a BFS sterile children's moisturizing oil as described in any one of claims 1 to 7, characterized in that: The following steps are involved: Step 1: Add 45 parts of sunflower seed oil, 9 parts of caprylic / capric triglyceride, 5 parts of jojoba seed oil, 2.5 parts of coconut oil, 2.5 parts of pomegranate seed oil, 0.5 parts of vitamin E and 0.08 parts of squalane into the liquid preparation tank, set the speed to 60-100 r / min, the rated frequency of magnetic stirring to 1400 rpm, control the solution temperature at 20°C-40°C, and stir and dissolve for 10 minutes; Step 2: Then add 0.02 parts of cholesterol, and after the addition is completed, stir and dissolve for 2 hours until it is completely dissolved to obtain the first solution; Step 3: Add the remaining sunflower seed oil and the remaining caprylic / capric triglyceride into a beaker, control the water bath temperature to 80°C-90°C, add 0.045 parts of ceramide AP and 0.035 parts of ceramide NP into the beaker, and after the addition is completed, stir and dissolve for 2 hours until completely dissolved to obtain a second solution; Step 4: Add the second solution to the first solution, then add 7 to 11 parts of the enhancer and 4 to 7 parts of the modifying additive, maintain the rotation speed and temperature, continue stirring for 30 minutes, transfer to a storage tank, and then fill and seal the container to obtain the BFS sterile children's moisturizing oil of the present invention.

9. Use of the BFS sterile children's moisturizing oil as claimed in any one of claims 1 to 7 in preventing mosquito bites.

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