Acne removal composition and preparation method thereof
By using the composition of Sophora glutinosa, white fresh root skin, windproof root, schizonepeta and white willow bark extract, the problem of the prone to drug resistance and toxic side effects of existing acne drugs is solved, and effective acne removal and oil control effects are achieved, while ensuring the safety of the product.
Patent Information
- Application Number
- CN202411991735.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-31
- Publication Date
- 2025-04-18
AI Technical Summary
Existing drugs for treating acne are prone to resistance to Propionibacter acnes, which has poor efficacy and toxic side effects, and cannot completely cure acne.
A composition for removing acne is adopted, including Sophora ginseng extract, white fresh root peel extract, windproof root extract, schizonepeta extract and white willow bark extract, which is prepared by breaking wall extraction and soaking extraction methods to form a colorless and transparent liquid with oil control and acne removal effect.
This composition can effectively inhibit skin aerobic bacteria and anaerobic bacteria, promote skin metabolism, achieve oil balance, and is safe and has no obvious irritation, and has good acne removal effect.
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Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of cosmetics, and in particular to an anti-acne composition and a preparation method thereof. Background Art
[0002] The most commonly used antibiotics for the treatment of acne in the market include macrolides, tetracyclines or clindamycin. Erythromycin is a representative macrolide antibiotic, which has a strong inhibitory effect on Propionibacterium acnes. However, studies have shown that the incidence of Propionibacterium acnes resistance in acne patients is increasing year by year, with erythromycin resistance being the most common, followed by tetracycline resistance. In addition, erythromycin also has cross-resistance, resulting in poorer drug efficacy. In addition, after long-term use of antibiotics, toxic and side effects such as dry skin, erythema, stinging, and itching may occur. Although the drugs have a certain effect, most of them are prone to drug resistance, cannot completely cure acne, and have large toxic and side effects. It can be seen that the defects of existing drugs for the treatment of acne are that they are prone to Propionibacterium acnes resistance and cannot completely cure acne.
[0003] In view of this, there is an urgent need for a plant composition with low skin irritation, strong epidermal permeability, good stability, environmental protection, and good acne removal effect to improve the deficiencies of the prior art. Summary of the invention
[0004] The main purpose of the present invention is to provide an anti-acne composition and a preparation method thereof, which can effectively solve the problems in the background technology.
[0005] To achieve the above object, the technical solution adopted by the present invention is: An acne-removing composition comprises, by weight, 0.1-10 parts of sophora flavescens extract, 0.1-10 parts of difficile root bark extract, 0.1-10 parts of siler root extract, 0.1-10 parts of schizonepeta extract and 1-10 parts of willow bark extract.
[0006] Preferably, the anti-acne composition comprises, by weight: 0.1-3 parts of Sophora flavescens extract, 0.1-3 parts of Dictamni root bark extract, 0.1-3 parts of Saposhnikovia root extract, 0.1-3 parts of Nepeta tenuifolia extract, and 0.5-1.5 parts of Salix alba bark extract.
[0007] Preferably, the anti-acne composition comprises, by weight: 2.5 parts of Sophora flavescens extract, 2.6 parts of Dictamni root bark extract, 2.1 parts of Saposhnikovia root extract, 1.8 parts of Nepeta tenuifolia extract, and 1 part of Salix alba bark extract.
[0008] A method for preparing the above-mentioned acne-removing composition, the specific steps are as follows: Step 1: Wash and dry Sophora flavescens, Dictamni root bark, Saposhnikovia root, Nepeta tenuifolia, and Willow bark, respectively, and put them into a wall-breaking machine to break the wall and grind them into powder, and put them into a container, add water 2-3 times the mass of the powder into the container, extract at 45-50°C, filter, separate the solid and liquid, and obtain a primary filter residue and a primary filtrate for standby use; Step 2: Put the primary filter residue into a container, add 2-3 times the mass of water into the container, heat and keep the temperature at 45-50°C, seal the container, inject air, control the pressure in the container to 1-1.2Mpa, soak and extract for 24-26h, press filter at 10-12Mpa, separate solid and liquid, and obtain secondary filtrate for standby use; Step 3: Combine the secondary filtrate with the primary filtrate, heat and concentrate to a paste; Step 4: drying the paste into powder to obtain extracts of Sophora flavescens, Dictamni root bark, Saposhnikovia root, Nepeta tenuifolia, and Salix alba bark; Step 5: accurately weigh the extracts of Sophora flavescens, Dictamni root bark, Saposhnikovia root, Schizonepeta tenuifolia, and Salix alba bark according to the ratio, put them into a container, add 10 times the volume of purified water, and mix well to obtain the acne-removing composition.
[0009] Preferably, in step 1, Sophora flavescens, Dictamni root bark, Saposhnikovia root, Nepeta tenuifolia, and Salix alba are crushed into powder with a size of 2-3 mm.
[0010] Preferably, in step 1, the extraction time at 45-50° C. is 6-8 hours.
[0011] Preferably, in step 4, the temperature at which the paste is dried into powder is 120-130°C.
[0012] Compared with the prior art, the present invention has the following beneficial effects: The salicylic acid in the white willow bark extract of the present invention can dissolve the constituent substances between the skin keratin, soften the skin keratin layer, make the keratin layer fall off, open the sebaceous gland duct opening blocked by oily substances, and promote the metabolism of the skin to achieve oil balance; and Sophora flavescens, Dictamni, Saposhnikovia divaricata, and Nepeta tenuifolia have the effects of inhibiting and killing various aerobic bacteria and anaerobic bacteria in skin acne, and have antioxidant and anti-inflammatory effects, which can synergistically enhance the oil control and acne removal effect of the acne removal composition on the skin. DETAILED DESCRIPTION
[0013] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.
[0014] Example 1 Step 1: Wash and dry Sophora flavescens, Dictamni root bark, Saposhnikovia root, Nepeta tenuifolia, and Willow bark, respectively, and put them into a wall-breaking machine to break the wall and crush them into powder (2-3 mm), and put them into a container, add 2-3 times the weight of the powder into the container, soak at 45-50℃ for 6-8h, filter, separate the solid and liquid, and obtain the primary filter residue and the primary filtrate for use; Step 2: Put the primary filter residue into a container, add 2-3 times the mass of water into the container, heat and keep the temperature at 45-50°C, seal the container, inject air, control the pressure in the container to 1-1.2Mpa, soak and extract for 24-26h, press filter at 10-12Mpa, separate solid and liquid, and obtain secondary filtrate for standby use; Step 3: Combine the secondary filtrate with the primary filtrate, heat and concentrate to a paste; Step 4: drying the paste at 120-130° C. into powder, respectively obtaining extracts of Sophora flavescens, Dictamni root bark, Saposhnikovia root, Nepeta tenuifolia, and Salix alba bark; Step 5: Accurately weigh 2.5 parts of Sophora flavescens extract, 2.6 parts of Dictamni root bark extract, 2.1 parts of Saposhnikovia root extract, 1.8 parts of Nepeta tenuifolia extract, and 1 part of Salix alba bark extract according to the ratio, put them into a container, add 10 times the volume of purified water, and mix well to obtain the acne-removing composition.
[0015] The composition prepared in this example is a colorless transparent liquid with a pH value of 6.0-7.0. It is stored at 45±2°C for 2 months and has no abnormality after returning to room temperature. It is stored at -18±2°C for 2 months and has no abnormality after returning to room temperature.
[0016] Example 2 In this embodiment, the content of each extract is adjusted on the basis of the embodiment 1, as follows: 2.4 parts of Sophora flavescens extract, 2.5 parts of Dictamni root bark extract, 2 parts of Saposhnikovia root extract, 1.7 parts of Nepeta tenuifolia extract, and 0.9 parts of Salix alba bark extract.
[0017] Example 3 In this embodiment, the content of each extract is adjusted on the basis of the embodiment 1, as follows: 2.6 parts of Sophora flavescens extract, 2.7 parts of Dictamni root bark extract, 2.2 parts of Saposhnikovia root extract, 1.9 parts of Nepeta tenuifolia extract, and 1.1 parts of Salix alba bark extract.
[0018] Example 4 In this embodiment, the content of each extract is adjusted on the basis of the embodiment 1, as follows: 1 part of Sophora flavescens extract, 1 part of Dictamni root bark extract, 1 part of Saposhnikovia root extract, 1 part of Nepeta tenuifolia extract, and 0.5 part of Salix alba bark extract.
[0019] Example 5 In this embodiment, the content of each extract is adjusted on the basis of the embodiment 1, as follows: 2 parts of Sophora flavescens extract, 2 parts of Dictamni root bark extract, 2 parts of Saposhnikovia root extract, 2 parts of Nepeta tenuifolia extract, and 1 part of Salix alba bark extract.
[0020] Example 6 In this embodiment, the content of each extract is adjusted on the basis of the embodiment 1, as follows: 3 parts of Sophora flavescens extract, 3 parts of Dictamni root bark extract, 3 parts of Saposhnikovia root extract, 3 parts of Nepeta tenuifolia extract, and 1.5 parts of Salix alba bark extract.
[0021] Example 7 In this embodiment, the content of each extract is adjusted on the basis of the embodiment 1, as follows: 2.5 parts of Sophora flavescens extract, 2.6 parts of Dictamni root bark extract, 2.1 parts of Parsnip root extract, 1.8 parts of Nepeta tenuifolia extract, and 1 part of Salix alba bark extract is replaced with 1 part of Salix alba leaf extract; The preparation method of the willow leaf extract is exactly the same as the preparation method of the white bark extract in Example 1.
[0022] Example 8 In this embodiment, the content of each extract is adjusted on the basis of the embodiment 1, as follows: 2.6 parts of Dictamni root bark extract, 2.1 parts of Saposhnikovia root extract, 1.8 parts of Nepeta tenuifolia extract, and 1 part of Salix alba bark extract. It should be noted that, in this example, Sophora flavescens extract was not added.
[0023] Comparative Example 1 In this comparative example, the content of each extract is adjusted on the basis of Example 1, as follows: 5 parts of Sophora flavescens extract, 5 parts of Dictamni root bark extract, 5 parts of Saposhnikovia root extract, 5 parts of Nepeta tenuifolia extract, and 2.5 parts of Salix alba bark extract.
[0024] Comparative Example 2 In this comparative example, the content of each extract is adjusted on the basis of Example 1, as follows: 0.1 parts of Sophora flavescens extract, 0.1 parts of Dictamni root bark extract, 0.1 parts of Saposhnikovia root extract, 0.1 parts of Nepeta tenuifolia extract, and 0.1 parts of Salix alba bark extract.
[0025] Comparative Example 3 In this comparative example, the content of each extract is adjusted on the basis of Example 1, as follows: 2.6 parts of Dictamni root bark extract, 2.1 parts of Saposhnikovia root extract, 1.8 parts of Nepeta tenuifolia extract, 0.9 parts of Salix alba bark extract. In this comparative example, no Sophora flavescens extract was added.
[0026] Comparative Example 4 In this comparative example, the content of each extract is adjusted on the basis of Example 1, as follows: 2.5 parts of Sophora flavescens extract, 2.1 parts of Saposhnikovia root extract, 1.8 parts of Nepeta tenuifolia extract, and 1 part of Salix alba bark extract. In this comparative example, no Dictamni root bark extract is added.
[0027] Comparative Example 5 In this comparative example, the content of each extract is adjusted on the basis of Example 1, as follows: 2.5 parts of Sophora flavescens extract, 2.6 parts of Dictamni root bark extract, 1.8 parts of Nepeta tenuifolia extract, 1 part of Salix alba bark extract. No radix silerii extract was added in this comparative example.
[0028] Comparative Example 6 In this comparative example, the content of each extract is adjusted on the basis of Example 1, as follows: 2.5 parts of Sophora flavescens extract, 2.6 parts of Dictamni root bark extract, 2.1 parts of Saposhnikovia root extract, 1 part of Salix alba bark extract. No Nepeta tenuifolia extract was added in this comparative example.
[0029] Comparative Example 7 In this comparative example, the content of each extract is adjusted on the basis of Example 1, as follows: 2.5 parts of Sophora flavescens extract, 2.6 parts of Dictamni root bark extract, 2.1 parts of Saposhnikovia root extract, 1.8 parts of Nepeta tenuifolia extract. This comparative example does not add Salix alba bark extract.
[0030] Comparative Example 8 This comparative example uses 2.5 parts of Sophora flavescens extract alone.
[0031] Comparative Example 9 This comparative example uses 2.6 parts of Dictamni root bark extract alone.
[0032] Comparative Example 10 This comparative example uses 2.1 parts of Radix Saposhnikoviae Root extract alone.
[0033] Comparative Example 11 In this comparative example, 1.8 parts of Nepeta extract was used alone.
[0034] Comparative Example 12 This comparative example uses 1 portion of white willow bark extract alone.
[0035] The safety of the anti-acne composition in Examples 1-8 and Comparative Examples 1-12 was investigated by using a chicken embryo chorioallantoic membrane test. This operation was performed in accordance with the People's Republic of China Entry-Exit Inspection and Quarantine Industry Standard SN / T2329-2009 "Chicken Embryo Chorioallantoic Membrane Test for Eye Irritation / Corrosion of Cosmetics"; specifically comprising the following steps: (1) Use tweezers to peel open the eggshell from the air chamber end of a 9-day-old egg, soak the inner membrane with 0.9% saline, and then carefully peel off the egg membrane from the edge to reveal the chorioallantoic membrane; (2) Use a pipette to take 0.3 mL of the test samples of Examples 1-8 and Comparative Examples 1-12, dissolve them in PBS (pH 7.0), dilute to a volume fraction of 1%, and then test; (3) After 3 minutes of timing, observe the changes in the blood vessels of the chorioallantoic membrane. Transparent test objects can be directly photographed for observation. Other test objects that are turbid or affect observation can be washed away with 0.9% saline before taking photos for observation. Use a magnifying glass lamp to observe the condition of the silicone rubber ring and the chick embryo chorioallantoic membrane. Vascular congestion, vascular hemorrhage, and ghost blood vessels are reactions to irritation.
[0036] If the observation shows that at least one reaction of all 6 chicken embryos is scored as moderate or above (total score ≥ 12), the test should be repeated once. Each chicken embryo score = the sum of the bleeding, coagulation and vascular melting observed in each chicken embryo; ES = the average of the mathematical sum of the scores of 6 chicken embryos. Each sample is tested in parallel 6 times. The chicken embryo test standard (safety endpoint evaluation standard) is shown in the following table: It can be concluded from the above table that the ES values of the anti-acne compositions of Examples 1-8 and Comparative Examples 1-12 are all ≤12, that is, all the anti-acne compositions are non-irritating or mildly irritating and have good safety.
[0037] The antibacterial properties of the acne-removing compositions in Examples 1-8 and Comparative Examples 1-12 are explored below: Staphylococcus aureus (ATCC6538) is a Gram-positive bacterium, Escherichia coli (ATCC8739) is a Gram-negative bacterium, and Candida albicans (ATCC 10231) is a fungus purchased from Guangdong Microbiological Culture Collection Center. Staphylococcus aureus and Escherichia coli were activated in Luria-Bertani (LB) medium at 37°C, and Candida albicans was activated in Sandburg agar medium at 37°C.
[0038] According to "7.3 Antibacterial effect test method of antibacterial daily chemical products (suspension quantitative method)" in "QBT 2738-2018 Evaluation method for antibacterial and antibacterial effects of daily chemical products", the antibacterial effect of each sample was measured. The measurement time was 20 minutes. The antibacterial rate (%) results are shown in Table 2.
[0039] It can be seen from the above table that the antibacterial and antimicrobial effects of the prepared acne-removing composition are stronger than the group ratios in Examples 1-3, especially in Example 1, 2.5 parts of Sophora flavescens extract, 2.6 parts of Dictamni root bark extract, 2.1 parts of Saposhnikovia root extract, 1.8 parts of Nepeta tenuifolia extract, and 1 part of Salix alba bark extract are the optimal solutions.
[0040] The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments. The above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected. The scope of protection of the present invention is defined by the attached claims and their equivalents.
Claims
1. An anti-acne composition, characterized in that: The composition comprises, by weight, 0.1-10 parts of Sophora flavescens extract, 0.1-10 parts of Dictamni root bark extract, 0.1-10 parts of Saposhnikovia root extract, 0.1-10 parts of Nepeta tenuifolia extract and 1-10 parts of Salix alba bark extract.
2. An anti-acne composition and a preparation method thereof according to claim 1, characterized in that: The anti-acne composition comprises, by weight, 0.1-3 parts of Sophora flavescens extract, 0.1-3 parts of Dictamni root bark extract, 0.1-3 parts of Saposhnikovia root extract, 0.1-3 parts of Nepeta tenuifolia extract, and 0.5-1.5 parts of Salix alba bark extract.
3. The anti-acne composition and preparation method thereof according to claim 1, characterized in that: The anti-acne composition comprises, by weight: 2.5 parts of Sophora flavescens extract, 2.6 parts of Dictamni root bark extract, 2.1 parts of Saposhnikovia root extract, 1.8 parts of Nepeta tenuifolia extract, and 1 part of Salix alba bark extract.
4. A method for preparing the anti-acne composition according to any one of claims 1 to 3, characterized in that: The specific steps are as follows: Step 1: Wash and dry Sophora flavescens, Dictamni root bark, Saposhnikovia root, Nepeta tenuifolia, and Willow bark, respectively, and put them into a wall-breaking machine to break the wall and grind them into powder, and put them into a container, add water 2-3 times the mass of the powder into the container, extract at 45-50°C, filter, separate the solid and liquid, and obtain a primary filter residue and a primary filtrate for standby use; Step 2: Put the primary filter residue into a container, add 2-3 times the mass of water into the container, heat and keep the temperature at 45-50°C, seal the container, inject air, control the pressure in the container to 1-1.2Mpa, soak and extract for 24-26h, press filter at 10-12Mpa, separate solid and liquid, and obtain secondary filtrate for standby use; Step 3: Combine the secondary filtrate with the primary filtrate, heat and concentrate to a paste; Step 4: drying the paste into powder to obtain extracts of Sophora flavescens, Dictamni root bark, Saposhnikovia root, Nepeta tenuifolia, and Salix alba bark; Step 5: Accurately weigh the extracts of Sophora flavescens, Dictamni root bark, Saposhnikovia root, Schizonepeta tenuifolia, and Salix alba bark according to the ratio, put them into a container, add 10 times the volume of purified water, and mix them evenly to obtain the acne-removing composition.
5. The method for preparing an anti-acne composition according to claim 4, characterized in that: In the step 1, the sophora flavescens, the root bark of Dictamni, the root of Saposhnikovia divaricata, the herb of Nepeta tenuifolia and the herb of Salix alba are crushed into powder with a size of 2-3 mm.
6. The method for preparing an anti-acne composition according to claim 4, characterized in that: In the step 1, the extraction time at 45-50° C. is 6-8 hours.
7. The method for preparing an anti-acne composition according to claim 4, characterized in that: In step 4, the temperature for drying the paste into powder is 120-130°C.