Composition with good permeability and whitening effect and preparation method thereof

Abstract

The invention relates to a composition with good permeability and a whitening effect and a preparation method thereof, and belongs to the technical field of skin care products. The composition disclosed by the invention comprises the following components in percentage by weight: 1-10% of a surfactant and 1-10% of a The invention relates to an anti-inflammatory and anti-inflammatory composition, which is prepared from the following components in percentage by weight: 0.5 to 3 percent of nicotinamide, 0.1 to 0.5 percent of ascorbic acid glucoside, 0.1 to 1 percent of tetrahydromethylpyrimidine carboxylic acid, 0.1 to 10 percent of mushroom mycelium extract solution, 0.05 to 5 percent of raspberry extract solution, 0.05 to 5 percent of wheat germ extract solution, 0.01 to 0.1 percent of decapeptide-4 solution, 0.001 to 1 percent of borneol solution, 0.05 to 1.2 percent of preservative, 0.05 to 2 percent of thickening agent and the balance of deionized water. The active ingredients of the composition prepared by the invention are good in permeability, and the composition has an excellent whitening effect and a very good market application prospect.

Description

Technical Field

[0001] The invention belongs to the technical field of skin care products, and particularly relates to a composition with good permeability and whitening effect and a preparation method thereof. Background Art

[0002] Skin care products refer to products used to protect, nourish and improve skin conditions. They are made of a variety of different active ingredients through reasonable proportions and compounding. According to different skin needs, most of the current skin care products are mainly whitening, oil control, spot lightening, moisturizing, etc., especially skin care products with whitening effects, which account for a very large scale in the market and are deeply loved by people. However, there are still many disadvantages in existing whitening skin care products that limit their actual application effects. This is because on the one hand, the active ingredients added to them have very limited effects on skin whitening. Most of them need to be used for a long time before some whitening effects can be seen. On the other hand, the skin is composed of the epidermis, dermis and subcutaneous tissue from the outside to the inside. Although the stratum corneum in the epidermis can effectively prevent the loss of water in the skin and the erosion of harmful substances from the outside, this also brings about the problem that the whitening active ingredients in the skin care products are difficult to "penetrate" and "permeate". A large number of studies have shown that most of the whitening skin care products applied by people are "blocked" by the stratum corneum and are difficult to be truly absorbed and utilized, which leads to a significant reduction in the application effect. Summary of the invention

[0003] In view of the problems existing in the prior art, the object of the present invention is to provide a composition with good permeability and whitening effect and a preparation method thereof.

[0004] The purpose of the present invention can be achieved through the following technical solutions:

[0005] A composition with good permeability and whitening effect comprises the following components: niacinamide, ascorbyl glucoside, ectoine, shiitake mycelium extract solution, raspberry extract solution, wheat germ extract solution, decapeptide-4 solution, borneol solution, preservative, thickener and deionized water.

[0006] As a preferred technical solution of the present invention, the composition comprises the following components: by weight percentage, 0.5-3% nicotinamide, 0.1-0.5% ascorbyl glucoside, 0.1-1% tetrahydromethylpyrimidine carboxylic acid, 0.1-10% shiitake mycelium extract solution, 0.05-5% raspberry extract solution, 0.05-5% wheat germ extract solution, 0.01-0.1% decapeptide-4 solution, 0.001-1% borneol solution, 0.05-1.2% preservative, 0.05-2% thickener and the balance deionized water.

[0007] As a preferred technical solution of the present invention, the composition comprises the following components: by weight percentage, 1% niacinamide, 0.2% ascorbyl glucoside, 0.5% tetrahydromethylpyrimidine carboxylic acid, 8% shiitake mycelium extract solution, 5% raspberry extract solution, 2% wheat germ extract solution, 0.05% decapeptide-4 solution, 0.4% borneol solution, 0.8% preservative, 0.25% thickener and the balance deionized water.

[0008] As a preferred technical solution of the present invention, the shiitake mycelium extract solution is prepared by mixing 0.4% of shiitake mycelium extract, 60% of glycerol and 39.6% of deionized water by weight percentage.

[0009] As a preferred technical solution of the present invention, the raspberry extract solution is prepared by mixing 15% of raspberry extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 83.9% of deionized water by weight.

[0010] As a preferred technical solution of the present invention, the wheat germ extract solution is prepared by mixing 2% wheat germ extract, 0.5% p-hydroxyacetophenone, 0.6% 1,2-hexanediol and 96.9% deionized water by weight.

[0011] As a preferred technical solution of the present invention, the decapeptide-4 solution is prepared by mixing, by weight percentage, 0.01% decapeptide-4, 0.9% sodium chloride, 0.15% disodium hydrogen phosphate, 0.01% glycoprotein and 98.93% deionized water.

[0012] As a preferred technical solution of the present invention, the borneol solution is prepared by mixing 0.1% borneol, 10% PEG-40 hydrogenated castor oil and 89.9% deionized water by weight.

[0013] As a preferred technical solution of the present invention, the preservative includes caprylhydroxamic acid, ethylhexylglycerol and butylene glycol; the mass ratio of the caprylhydroxamic acid, the ethylhexylglycerol and the butylene glycol is 10-15:5-10:80.

[0014] As a preferred technical solution of the present invention, the thickener is at least one of carbomer, acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, sodium acrylate / sodium acryloyldimethyl taurate copolymer, sodium polyacrylate, ammonium acryloyldimethyl taurate / VP copolymer, hydroxyethyl cellulose, hydroxypropyl methylcellulose, hydrolyzed sclerotium (SCLEROTIUM ROLFSSII) gum and xanthan gum.

[0015] A method for preparing a composition with good permeability and whitening effect, the preparation method comprising the following steps:

[0016] Step X: Add a thickener to deionized water according to the formula amount, and then stir and mix at a constant temperature of 60-70° C. for 30-45 minutes, cool naturally to 45-50° C. and keep warm, add nicotinamide, ascorbyl glucoside, tetrahydromethylpyrimidine carboxylic acid, shiitake mycelium extract solution, raspberry extract solution, wheat germ extract solution, decapeptide-4 solution and borneol solution, stir and mix at a constant temperature of 45-60 minutes, then add a preservative, continue to stir and mix at a constant temperature of 15-30 minutes, cool naturally to room temperature, and the preparation is completed.

[0017] Niacinamide is a classic ingredient in skin care products with whitening effects. It can reduce the transport of melanin to the surface of the skin, thereby reducing melanin deposition and brightening the skin tone. At the same time, it also has a certain inhibitory ability on the activity of tyrosinase, thereby reducing the synthesis of melanin. In addition, niacinamide can also accelerate the metabolism of melanin and promote the renewal of skin cells. Finally, niacinamide can achieve skin whitening through multiple pathways. The present invention still selects it as the most basic whitening active ingredient, and further amplifies and enhances the whitening effect by compounding with other substances.

[0018] Ascorbyl glucoside is a derivative of vitamin C. Due to the poor stability of vitamin C, it is prone to oxidation during actual use, thus losing its whitening effect. Ascorbyl glucoside can solve this problem very well. When ascorbyl glucoside is absorbed by the skin, it will gradually convert into vitamin C, thereby exerting its whitening effect. By reducing the synthesis of dopaquinone and promoting its reduction to dopa, it can block the melanin production chain and achieve the effect of promoting whitening. More importantly, since "tanning" is the main factor for skin darkening, ascorbyl glucoside can greatly reduce the various free radicals produced by ultraviolet radiation, thereby playing a protective role before "darkening".

[0019] Tetrahydromethylpyrimidine carboxylic acid, also known as ectoine, is an amino acid derivative with excellent safety and stability. It mainly repairs cells damaged by ultraviolet rays and improves their resistance to ultraviolet rays, thereby reducing the production of melanin to a certain extent, promoting whitening effects, and playing a repairing role after "darkening".

[0020] Shiitake mushroom mycelium extract is rich in polysaccharides, trace elements, terpenoids and other bioactive substances. It has a good activating effect on skin cells, can coordinate the natural renewal of skin cells, and balance the effects of protection and repair. At the same time, it not only has a certain active inhibitory effect on melanocytes, but also when compounded with other whitening active ingredients, it can produce a good synergistic effect and jointly promote the whitening effect.

[0021] Raspberry extract is an emerging natural plant extract, which is mainly composed of active ingredients such as flavonoids and organic acids. Among them, there are more than 50 organic acid compounds, such as ellagic acid, salicylic acid, shikimic acid, gallic acid, oxalic acid, malic acid, citric acid, etc. Therefore, when it acts on the skin surface, it can soften the stratum corneum, thereby weakening its "barrier" effect to a certain extent, opening channels, and promoting the penetration of whitening active ingredients, so that human skin can better absorb them.

[0022] Wheat germ extract is a new type of food rich in spermidine, which has been widely used in the field of food additives to supplement nutrients for the human body. The present invention adds a certain amount of wheat germ extract to the composition. Based on the fact that spermidine is easily ionized into positively charged molecules, it can be hydrogen-bonded with negatively charged groups on the skin cell membrane, such as phosphate groups, through electrostatic interactions, thereby producing a cell internalization effect and promoting the penetration of whitening active ingredients.

[0023] Decapeptide-4 is a synthetic peptide composed of multiple amino acids such as arginine, aspartic acid, cysteine, glutamic acid, etc. It is the earliest peptide substance used in transdermal mediation. It can not only penetrate into cells well, but also carry other active ingredients and promote their penetration in the stratum corneum, achieving excellent penetration-enhancing effect.

[0024] Borneol is widely used in the cosmetics field as a skin conditioning agent. In the composition, it mainly destroys the ordered lipid structure in the stratum corneum, thereby achieving the penetration-promoting effect on whitening active ingredients, especially for the tightly connected structure between cells, which can make it looser, thereby facilitating the diffusion of whitening active ingredients and better exerting the whitening effect.

[0025] Beneficial effects of the present invention:

[0026] (1) The present invention creatively adds ascorbyl glucoside, ectoine and shiitake mycelium extract to niacinamide as a classic whitening active ingredient, thereby giving the composition a more excellent whitening effect; niacinamide can play a whitening effect in multiple ways such as reducing melanin deposition, inhibiting the activity of tyrosinase, and accelerating the metabolism of melanin, while ascorbyl glucoside and ectoine have the effects of protecting and repairing the skin before and after "darkening", respectively. At the same time, ascorbyl glucoside can also block the production chain of melanin. As for the shiitake mycelium extract, it can inhibit the activity of melanocytes, thereby promoting skin whitening. In addition, it can have a good activation effect on skin cells, synergistically enhance the synergy of other whitening active ingredients, and amplify the final whitening effect.

[0027] (2) The present invention is based on the problem that current whitening active ingredients are difficult to "penetrate" and "infiltrate". Most of them are "blocked" from the stratum corneum and difficult to be truly absorbed and utilized. The present invention creatively adds raspberry extract, wheat germ extract, decapeptide-4 and borneol into the composition as a composite penetration enhancer, which together play an excellent penetration enhancing role. Raspberry extract can soften the stratum corneum and weaken its "barrier" effect. Wheat germ extract is rich in spermidine and is easily ionized into positively charged molecules to form hydrogen bonds with negatively charged groups on the cell membrane, thereby producing a cellular internalization effect and promoting the penetration of whitening active ingredients. Decapeptide-4 itself is a transdermal-mediated peptide substance with an excellent penetration enhancing effect. As for borneol, it can destroy the ordered lipid structure in the stratum corneum, making it looser, thereby facilitating the diffusion of whitening active ingredients.

[0028] (3) The compositions prepared by the present invention mostly use natural plant extracts, vitamin derivatives, and amino acid derivatives as main ingredients, and have the characteristics of high safety and low irritation. At the same time, when they act on human skin, they can have a good whitening effect and have very good market application prospects. DETAILED DESCRIPTION

[0029] In order to further illustrate the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the specific implementation methods, structures, features and effects of the present invention are described in detail below in combination with the embodiments.

[0030] The shiitake mycelium extracts in all the embodiments and comparative examples of the present invention are purchased directly from the market, purchased from Guangzhou Mingqi Biotechnology Co., Ltd., with a product specification of 10:1; the raspberry extracts are purchased directly from the market, purchased from Guangzhou Zhenyoumei New Material Technology Co., Ltd., with a product specification of 10:1; the wheat germ extracts are purchased directly from the market, purchased from Guangzhou Mingqi Biotechnology Co., Ltd., with a product specification of 10:1; the decapeptide-4s are purchased directly from the market, purchased from Fujian Longsheng Biotechnology Co., Ltd.; the glycoproteins are purchased directly from the market, purchased from Fujian Longsheng Biotechnology Co., Ltd.; the PEG-40 hydrogenated castor oils are purchased directly from the market, purchased from BASF (China) Co., Ltd.; the borneols are purchased directly from the market, purchased from Nanjing Lizhihong Biotechnology Co., Ltd., and the product name is natural borneol (dextrorotatory borneol); the xanthan gums are purchased directly from the market, purchased from Cosphatec GmbH, and the product name is X 34.

[0031] Example 1

[0032] A composition with good permeability and whitening effect comprises the following components: by weight percentage, 1% of nicotinamide, 0.2% of ascorbyl glucoside, 0.5% of tetrahydromethylpyrimidine carboxylic acid, 8% of shiitake mycelium extract solution, 5% of raspberry extract solution, 2% of wheat germ extract solution, 0.05% of decapeptide-4 solution, 0.4% of borneol solution, 0.8% of preservative, 0.25% of thickener and the balance of deionized water.

[0033] In terms of weight percentage, the shiitake mycelium extract solution is prepared by mixing 0.4% of shiitake mycelium extract, 60% of glycerol and the remainder of deionized water.

[0034] The raspberry extract solution is prepared by mixing 15% of raspberry extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 83.9% of deionized water by weight.

[0035] The wheat germ extract solution is prepared by mixing 2% of wheat germ extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 96.9% of deionized water by weight.

[0036] In terms of weight percentage, the decapeptide-4 solution is prepared by mixing 0.01% decapeptide-4, 0.9% sodium chloride, 0.15% disodium hydrogen phosphate, 0.01% glycoprotein and 98.93% deionized water.

[0037] In terms of weight percentage, the borneol solution is prepared by mixing 0.1% borneol, 10% PEG-40 hydrogenated castor oil and 89.9% deionized water.

[0038] The preservative comprises caprylhydroxamic acid, ethylhexylglycerin and butylene glycol; the mass ratio of the caprylhydroxamic acid, the ethylhexylglycerin and the butylene glycol is 12:8:80.

[0039] The thickener is xanthan gum.

[0040] A method for preparing a composition with good permeability and whitening effect, the preparation method comprising the following steps:

[0041] Step X: Add a thickener to deionized water according to the formula amount, and then stir and mix at a constant temperature of 60° C. for 30 minutes, cool naturally to 45° C. and keep warm, add nicotinamide, ascorbyl glucoside, tetrahydromethylpyrimidine carboxylic acid, shiitake mycelium extract solution, raspberry extract solution, wheat germ extract solution, decapeptide-4 solution and borneol solution, stir and mix at a constant temperature for 45 minutes, then add a preservative, continue to stir and mix at a constant temperature for 15 minutes, cool naturally to room temperature, and the preparation is completed.

[0042] Example 2

[0043] A composition with good permeability and whitening effect comprises the following components: by weight percentage, 0.5% of nicotinamide, 0.1% of ascorbyl glucoside, 0.1% of tetrahydromethylpyrimidine carboxylic acid, 0.1% of shiitake mycelium extract solution, 0.05% of raspberry extract solution, 0.05% of wheat germ extract solution, 0.01% of decapeptide-4 solution, 0.001% of borneol solution, 0.05% of preservative, 0.05% of thickener and the balance of deionized water.

[0044] In terms of weight percentage, the shiitake mycelium extract solution is prepared by mixing 0.4% of shiitake mycelium extract, 60% of glycerol and 39.6% of deionized water.

[0045] The raspberry extract solution is prepared by mixing 15% of raspberry extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 83.9% of deionized water by weight.

[0046] The wheat germ extract solution is prepared by mixing 2% of wheat germ extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 96.9% of deionized water by weight.

[0047] In terms of weight percentage, the decapeptide-4 solution is prepared by mixing 0.01% decapeptide-4, 0.9% sodium chloride, 0.15% disodium hydrogen phosphate, 0.01% glycoprotein and 98.93% deionized water.

[0048] In terms of weight percentage, the borneol solution is prepared by mixing 0.1% borneol, 10% PEG-40 hydrogenated castor oil and 89.9% deionized water.

[0049] The preservative comprises caprylhydroxamic acid, ethylhexylglycerin and butylene glycol; the mass ratio of the caprylhydroxamic acid, the ethylhexylglycerin and the butylene glycol is 10:5:80.

[0050] The thickener is xanthan gum.

[0051] A method for preparing a composition with good permeability and whitening effect, the preparation method comprising the following steps:

[0052] Step X: Add a thickener to deionized water according to the formula amount, and then stir and mix at a constant temperature of 60° C. for 30 minutes, cool naturally to 45° C. and keep warm, add nicotinamide, ascorbyl glucoside, tetrahydromethylpyrimidine carboxylic acid, shiitake mycelium extract solution, raspberry extract solution, wheat germ extract solution, decapeptide-4 solution and borneol solution, stir and mix at a constant temperature for 45 minutes, then add a preservative, continue to stir and mix at a constant temperature for 15 minutes, cool naturally to room temperature, and the preparation is completed.

[0053] Example 3

[0054] A composition with good permeability and whitening effect comprises the following components: by weight percentage, 3% of nicotinamide, 0.5% of ascorbyl glucoside, 1% of tetrahydromethylpyrimidine carboxylic acid, 10% of shiitake mycelium extract solution, 5% of raspberry extract solution, 5% of wheat germ extract solution, 0.1% of decapeptide-4 solution, 1% of borneol solution, 1.2% of preservative, 2% of thickener and the balance of deionized water.

[0055] In terms of weight percentage, the shiitake mycelium extract solution is prepared by mixing 0.4% of shiitake mycelium extract, 60% of glycerol and 39.6% of deionized water.

[0056] The raspberry extract solution is prepared by mixing 15% of raspberry extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 83.9% of deionized water by weight.

[0057] The wheat germ extract solution is prepared by mixing 2% of wheat germ extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 96.9% of deionized water by weight.

[0058] In terms of weight percentage, the decapeptide-4 solution is prepared by mixing 0.01% decapeptide-4, 0.9% sodium chloride, 0.15% disodium hydrogen phosphate, 0.01% glycoprotein and 98.93% deionized water.

[0059] In terms of weight percentage, the borneol solution is prepared by mixing 0.1% borneol, 10% PEG-40 hydrogenated castor oil and 89.9% deionized water.

[0060] The preservative comprises caprylhydroxamic acid, ethylhexylglycerin and butylene glycol; the mass ratio of the caprylhydroxamic acid, the ethylhexylglycerin and the butylene glycol is 15:10:80.

[0061] The thickener is xanthan gum.

[0062] A method for preparing a composition with good permeability and whitening effect, the preparation method comprising the following steps:

[0063] Step X: Add a thickener to deionized water according to the formula amount, and then stir and mix at a constant temperature of 70° C. for 45 minutes, cool naturally to 50° C. and keep warm, add nicotinamide, ascorbyl glucoside, tetrahydromethylpyrimidine carboxylic acid, shiitake mycelium extract solution, raspberry extract solution, wheat germ extract solution, decapeptide-4 solution and borneol solution, stir and mix at a constant temperature for 60 minutes, then add a preservative, continue to stir and mix at a constant temperature for 30 minutes, cool naturally to room temperature, and the preparation is completed.

[0064] Example 4

[0065] A composition with good permeability and whitening effect comprises the following components: by weight percentage, 2% of nicotinamide, 0.3% of ascorbyl glucoside, 0.5% of tetrahydromethylpyrimidine carboxylic acid, 7% of shiitake mycelium extract solution, 2% of raspberry extract solution, 2% of wheat germ extract solution, 0.08% of decapeptide-4 solution, 0.7% of borneol solution, 0.08% of preservative, 0.2% of thickener and 85.14% of deionized water.

[0066] In terms of weight percentage, the shiitake mycelium extract solution is prepared by mixing 0.4% of shiitake mycelium extract, 60% of glycerol and 39.6% of deionized water.

[0067] The raspberry extract solution is prepared by mixing 15% of raspberry extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 83.9% of deionized water by weight.

[0068] The wheat germ extract solution is prepared by mixing 2% of wheat germ extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 96.9% of deionized water by weight.

[0069] In terms of weight percentage, the decapeptide-4 solution is prepared by mixing 0.01% decapeptide-4, 0.9% sodium chloride, 0.15% disodium hydrogen phosphate, 0.01% glycoprotein and 98.93% deionized water.

[0070] In terms of weight percentage, the borneol solution is prepared by mixing 0.1% borneol, 10% PEG-40 hydrogenated castor oil and 89.9% deionized water.

[0071] The preservative comprises caprylhydroxamic acid, ethylhexylglycerin and butylene glycol; the mass ratio of the caprylhydroxamic acid, the ethylhexylglycerin and the butylene glycol is 13:8:80.

[0072] The thickener is xanthan gum.

[0073] A method for preparing a composition with good permeability and whitening effect, the preparation method comprising the following steps:

[0074] Step X: Add a thickener to deionized water according to the formula amount, and then stir and mix at a constant temperature of 65° C. for 40 minutes, cool naturally to 48° C. and keep warm, add nicotinamide, ascorbyl glucoside, tetrahydromethylpyrimidine carboxylic acid, shiitake mycelium extract solution, raspberry extract solution, wheat germ extract solution, decapeptide-4 solution and borneol solution, stir and mix at a constant temperature for 50 minutes, then add a preservative, continue to stir and mix at a constant temperature for 25 minutes, cool naturally to room temperature, and the preparation is completed.

[0075] Comparative Example 1

[0076] On the basis of Example 1, nicotinamide was replaced by ascorbyl glucoside in an equal weight, and the rest remained unchanged.

[0077] Comparative Example 2

[0078] Based on Example 1, ascorbyl glucoside was replaced by an equal weight of ectoine, and the rest remained unchanged.

[0079] Comparative Example 3

[0080] On the basis of Example 1, the ectoine was replaced by an equal weight of Lentinus edodes mycelium extract, and the rest remained unchanged.

[0081] Comparative Example 4

[0082] On the basis of Example 1, the shiitake mycelium extract was replaced with an equal weight of nicotinamide, and the rest remained unchanged.

[0083] Comparative Example 5

[0084] On the basis of Example 1, the raspberry extract was replaced by an equal weight of wheat germ extract, and the rest remained unchanged.

[0085] Comparative Example 6

[0086] On the basis of Example 1, the wheat germ extract was replaced with an equal weight of decapeptide-4, and the rest remained unchanged.

[0087] Comparative Example 7

[0088] Based on Example 1, decapeptide-4 was replaced by borneol of equal weight, and the rest remained unchanged.

[0089] Comparative Example 8

[0090] On the basis of Example 1, borneol was replaced with an equal weight of raspberry extract, and the rest remained unchanged.

[0091] Comparative Example 9

[0092] On the basis of Example 1, nicotinamide, ascorbyl glucoside, ectoine and Lentinus edodes mycelium extract were replaced with deionized water of equal weight, and the rest remained unchanged.

[0093] Comparative Example 10

[0094] On the basis of Example 1, raspberry extract, wheat germ extract, decapeptide-4 and borneol were replaced with equal weights of deionized water, and the rest remained unchanged.

[0095] Test Example 1

[0096] Whitening effect test:

[0097] Here are the steps:

[0098] (1) 300 volunteers (aged 24-35 years, female, with facial IT A° values ​​stable between 20-25° in the past 30 days) were selected and randomly divided into 15 groups, with 20 people in each group.

[0099] (2) Each group was smeared with the whitening composition prepared in Examples 1-4 and Comparative Examples 1-10 (one group was a blank group, smeared with deionized water), and the smearing conditions were: twice a day, 2 mL each time, the residence time was 6 hours and then washed with deionized water, and the smearing was continued for 30 days, and the smearing position was the face.

[0100] (3) After continuous application for 30 days, retest the ITA° value of the face and calculate the average growth rate. The larger the average growth rate, the lighter the skin color and the better the whitening effect.

[0101] Table 1. Whitening effect test results

[0102]

[0103]

[0104] From Test Example 1, it can be seen from the comparison between Example 1 and Comparative Examples 1-10 that the composition prepared by the present invention has excellent whitening effect and good permeability of whitening active ingredients; Comparative Example 9 does not add whitening active ingredients, but the improvement of whitening is very limited, which indirectly indicates that it is difficult to substantially participate in whitening, and more importantly, it has a penetration-promoting effect on other whitening active ingredients; Comparative Example 10 does not add a composite penetration enhancer, although it also has a whitening effect to a certain extent, but the effect still has a lot of room for improvement; Comparative Examples 1-8 have an adverse effect on the whitening effect after replacing any whitening active ingredient or penetration enhancer, but the effect is still better than that of Comparative Examples 9 and 10.

[0105] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment as above, it is not used to limit the present invention. Any technical personnel in this field can make some changes or modify the technical contents disclosed above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any brief modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. A composition with good permeability and whitening effect, characterized in that: The composition comprises the following components: nicotinamide, ascorbyl glucoside, ectoine, shiitake mycelium extract solution, raspberry extract solution, wheat germ extract solution, decapeptide-4 solution, borneol solution, preservative, thickener and deionized water.

2. A composition with good permeability and whitening effect according to claim 1, characterized in that: The composition comprises the following components: by weight percentage, 0.5-3% of nicotinamide, 0.1-0.5% of ascorbyl glucoside, 0.1-1% of tetrahydromethylpyrimidine carboxylic acid, 0.1-10% of shiitake mycelium extract solution, 0.05-5% of raspberry extract solution, 0.05-5% of wheat germ extract solution, 0.01-0.1% of decapeptide-4 solution, 0.001-1% of borneol solution, 0.05-1.2% of preservative, 0.05-2% of thickener and the balance of deionized water.

3. A composition with good permeability and whitening effect according to claim 1, characterized in that: The composition comprises the following components: by weight percentage, 1% of nicotinamide, 0.2% of ascorbyl glucoside, 0.5% of tetrahydromethylpyrimidine carboxylic acid, 8% of shiitake mycelium extract solution, 5% of raspberry extract solution, 2% of wheat germ extract solution, 0.05% of decapeptide-4 solution, 0.4% of borneol solution, 0.8% of preservative, 0.25% of thickener and the balance of deionized water.

4. A composition with good permeability and whitening effect according to claim 1, characterized in that: In terms of weight percentage, the shiitake mycelium extract solution is prepared by mixing 0.4% of shiitake mycelium extract, 60% of glycerol and 39.6% of deionized water.

5. The composition with good permeability and whitening effect according to claim 1, characterized in that: The raspberry extract solution is prepared by mixing 15% of raspberry extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 83.9% of deionized water by weight.

6. A composition with good permeability and whitening effect according to claim 1, characterized in that: The wheat germ extract solution is prepared by mixing 2% of wheat germ extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 96.9% of deionized water by weight.

7. A composition with good permeability and whitening effect according to claim 1, characterized in that: In terms of weight percentage, the decapeptide-4 solution is prepared by mixing 0.01% decapeptide-4, 0.9% sodium chloride, 0.15% disodium hydrogen phosphate, 0.01% glycoprotein and 98.93% deionized water.

8. The composition with good permeability and whitening effect according to claim 1, characterized in that: In terms of weight percentage, the borneol solution is prepared by mixing 0.1% borneol, 10% PEG-40 hydrogenated castor oil and 89.9% deionized water.

9. The composition with good permeability and whitening effect according to claim 1, characterized in that: The thickener is at least one of carbomer, acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, sodium acrylate / sodium acryloyldimethyl taurate copolymer, sodium polyacrylate, ammonium acryloyldimethyl taurate / VP copolymer, hydroxyethyl cellulose, hydroxypropyl methylcellulose, hydrolyzed sclerotium (SCLEROTIUMROLFSSII) gum and xanthan gum.

10. A method for preparing a composition with good permeability and whitening effect as claimed in any one of claims 1 to 9, characterized in that: The preparation method comprises the following steps: Step X: Add a thickener to deionized water according to the formula amount, and then stir and mix at a constant temperature of 60-70° C. for 30-45 minutes, cool naturally to 45-50° C. and keep warm, add nicotinamide, ascorbyl glucoside, tetrahydromethylpyrimidine carboxylic acid, shiitake mycelium extract solution, raspberry extract solution, wheat germ extract solution, decapeptide-4 solution and borneol solution, stir and mix at a constant temperature of 45-60 minutes, then add a preservative, continue to stir and mix at a constant temperature of 15-30 minutes, cool naturally to room temperature, and the preparation is completed.

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