Traditional Chinese medicine composition for treating chronic laryngitis and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic laryngitis. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 20-35 parts of astragalus membranaceus, 20-35 parts of adenophora tetraphylla, 20-35 parts of Chinese yam, 3-6 parts of membrane of hen egg, 3-6 parts of oroxylum indicum, 20-35 parts of selfheal, 12-25 parts of scaphium scaphigerum, 12-25 parts of platycodon grandiflorum and 6-15 parts of liquorice. The traditional Chinese medicine composition provided by the invention has the effects of tonifying qi, opening voice, nourishing yin, clearing away the lung-heat, reducing phlegm and resolving masses, and has the effects of tonifying qi, nourishing yin, clearing away the lung-heat, relieving cough, eliminating phlegm, relieving sore throat and the like; the symptoms such as vocal cord hyperemia, hoarseness, dry pain and discomfort in throat, dry cough and the like can be effectively improved.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating chronic laryngitis and application thereof. Background Art

[0002] Chronic laryngitis refers to a chronic inflammatory disease of the laryngeal mucosa caused by long-term improper use of the voice or non-specific bacterial infection. It is a common clinical disease with hoarseness, throat discomfort, and increased laryngeal secretions as the main manifestations. In traditional Chinese medicine, it belongs to the category of chronic laryngitis. As early as in "Suwen·Pulse Interpretation", there was a specific description of this disease: "The so-called entry into the middle is muting, and the yang is strong and has declined, so it is muting. If the internal is lost and fainted, it is muting and urticaria, which is kidney deficiency" (Zhu Huilan, Shi Jun, Qiao Zhi, et al. Analysis of the medication rules of Gan Zuwang, a national medical master, in the treatment of chronic laryngitis [J]. Shandong Journal of Traditional Chinese Medicine, 2023, 42(03): 209-215.). Traditional Chinese medicine believes that the occurrence of chronic laryngitis is closely related to the lungs, spleen, and kidneys. Clinically, it is often divided into lung and kidney yin deficiency, lung and spleen qi deficiency, qi stagnation, blood stasis, and phlegm coagulation. Clinically, lung and kidney yin deficiency is more common, or combined with qi and yin deficiency, or combined with qi stagnation, blood stasis, and phlegm coagulation. Currently, commonly used Chinese herbal compound prescriptions are mainly used to treat a single syndrome, such as Baihe Gujin Pills which nourish yin and moisten the lungs, resolve phlegm and relieve cough; Yangyin Qingfei Pills which nourish yin and moisten dryness, clear the lungs and relieve sore throat; Jinsang Kaiyin Pills which clear away heat and detoxify, soothe wind and relieve sore throat, etc. Summary of the invention

[0003] The invention aims to provide a Chinese medicine composition for treating chronic laryngitis, which has the effects of invigorating qi, improving voice, nourishing yin, clearing lungs, and resolving phlegm and dispersing stagnation.

[0004] Another object of the present invention is to provide an application of the traditional Chinese medicine composition in the preparation of a medicine for treating chronic laryngitis.

[0005] In order to achieve the above object, the technical solution adopted by the present invention is as follows:

[0006] The first aspect of the present invention provides a traditional Chinese medicine composition for treating chronic laryngitis, which is prepared from the following components in parts by weight: 20-35 parts of astragalus, 20-35 parts of adenophora australis, 20-35 parts of yam, 3-6 parts of phoenix vine, 3-6 parts of jade butterfly, 20-35 parts of selfheal, 12-25 parts of sterculia lychnophora, 12-25 parts of platycodon, and 6-15 parts of liquorice.

[0007] The Chinese medicine composition for treating chronic laryngitis is prepared from the following components in parts by weight:

[0008] 35 parts of Astragalus, 35 parts of Adenophora australis, 35 parts of Dioscorea opposita, 6 parts of Herba Lycopodii, 6 parts of Herba Prunellae, 35 parts of Herba Sterculiae, 25 parts of Platycodon grandiflori, and 15 parts of Radix Glycyrrhizae.

[0009] The Chinese medicine composition for treating chronic laryngitis is prepared from the following components in parts by weight:

[0010] 30 parts of Astragalus, 30 parts of Adenophora australis, 30 parts of Dioscorea opposita, 5 parts of Herba Lycopodii, 5 parts of Herba Prunellae, 30 parts of Herba Sterculiae, 20 parts of Platycodon grandiflori, and 10 parts of Radix Glycyrrhizae.

[0011] The Chinese medicine composition for treating chronic laryngitis is prepared from the following components in parts by weight:

[0012] 25 parts of Astragalus, 25 parts of Adenophora australis, 25 parts of Dioscorea opposita, 4 parts of Herba Lycopodii, 4 parts of Herba Prunellae, 25 parts of Herba Sterculiae, 15 parts of Platycodon grandiflorum, and 9 parts of Radix Glycyrrhizae.

[0013] The Chinese medicine composition for treating chronic laryngitis is prepared from the following components in parts by weight:

[0014] 20 parts of Astragalus, 20 parts of Adenophora australis, 20 parts of Dioscorea opposita, 3 parts of Herba Lycopodii, 3 parts of Herba Prunellae, 20 parts of Herba Sterculiae, 13 parts of Platycodon grandiflorum, and 6 parts of Radix Glycyrrhizae.

[0015] The Chinese medicine composition for treating chronic laryngitis is prepared from the following components in parts by weight:

[0016] 20 parts of Astragalus, 20 parts of Adenophora australis, 20 parts of Dioscorea opposita, 3 parts of Herba Lycopodii, 3 parts of Herba Prunellae, 20 parts of Herba Sterculiae, 12 parts of Platycodon grandiflorum, and 6 parts of Radix Glycyrrhizae.

[0017] The second aspect of the present invention provides a pharmaceutical preparation made from the traditional Chinese medicine composition.

[0018] The dosage form of the pharmaceutical preparation is oral liquid, tablet, capsule, or pill.

[0019] The pharmaceutical preparation is an oral medicine.

[0020] The preparation method of the oral liquid comprises the following steps:

[0021] According to the ratio of the Chinese medicine composition, water is added to the Chinese medicine composition and decocted twice, the first time for 1 to 2 hours (preferably 2 hours) and the second time for 1 to 2 hours (preferably 1.5 hours), and the filtrates are combined to obtain a primary concentrated solution; the primary concentrated solution is placed at room temperature, an ethanol aqueous solution is added to the primary concentrated solution, and the solution is refrigerated at a temperature of 2-10°C for 1 to 48 hours (preferably 48 hours), and the solution is concentrated under reduced pressure until the concentrated solution does not contain ethanol, thereby obtaining a secondary concentrated solution; distilled water is added to the secondary concentrated solution, and the solution is refrigerated by water precipitation, and the solution is refrigerated at a temperature of 2-10°C for 1 to 48 hours (preferably 48 hours), filtered, and the filtrate is collected, white sugar and sodium benzoate (the weight ratio of white sugar to sodium benzoate is 4:1) are added, purified water is added, the solution is mixed well, filtered, and boiled for sterilization (2 hours) to obtain an oral solution for treating chronic laryngitis.

[0022] The third aspect of the present invention provides a use of the traditional Chinese medicine composition in the preparation of a medicine for treating chronic laryngitis.

[0023] The chronic laryngitis is caused by deficiency of lung and kidney yin or deficiency of both qi and yin, or concurrent qi stagnation, blood stasis and phlegm coagulation in traditional Chinese medicine.

[0024] The fourth aspect of the present invention provides a use of the traditional Chinese medicine composition in preparing medicines for invigorating qi and promoting voice, medicines for nourishing yin and clearing the lungs, and medicines for resolving phlegm and dispersing nodules.

[0025] The Chinese medicine composition of the present invention is mainly used for the treatment of chronic laryngitis, mainly for invigorating qi and improving voice, nourishing yin and clearing lungs, and resolving phlegm and dispersing stagnation.

[0026] The properties, flavors, meridians and functions of the Chinese medicine raw materials of the present invention are as follows:

[0027] Astragalus: sweet, slightly warm. Enters the spleen and lung meridians. Efficacy: replenishes qi and strengthens the spleen, raises yang and lifts the sunken, strengthens the body's defense and consolidates the exterior, promotes diuresis and reduces swelling, removes toxins and regenerates muscles. Enters the lung meridian to replenish lung qi, and can be used for those with weak lung qi, long-term cough and asthma, shortness of breath and fatigue. "Compendium of Materia Medica" says: "It is a medicine that replenishes the lungs and strengthens the spleen, strengthens the defense and restrains sweat, and drives away wind and transports toxins." Pharmacology shows that it has the effects of improving immunity, antibacterial and antiviral.

[0028] Adenophora australis: sweet, slightly cold. Enters the lung and stomach meridians. Efficacy: nourishes yin and clears the lungs, benefits the stomach and produces fluid, replenishes qi, and resolves phlegm. It can replenish lung yin, moisten lung dryness, and clear lung heat. It is suitable for dry cough with little sputum, hemoptysis, or dry throat and hoarseness due to yin deficiency, lung dryness, and heat. "New Reference to Decoction Pieces": "Clears the lungs and nourishes yin, treats asthenia, cough, sputum, and blood." Pharmacology shows that it has antitussive and expectorant, anti-inflammatory, and immune regulation effects.

[0029] Chinese Yam: sweet, neutral. Enters the spleen, lung, and kidney meridians. Efficacy: replenishes qi and nourishes yin, nourishes the spleen, lungs, and kidneys, consolidates essence and stops leukorrhea. It can replenish lung qi and nourish lung yin, and is mainly used to treat lung deficiency syndrome. "Shennong's Herbal Classic" says: "It replenishes the middle, replenishes qi and strength, and grows muscles." "Compendium of Materia Medica" says: "It replenishes kidney qi and strengthens the spleen and stomach." Pharmacology shows that it has the effects of regulating intestinal motility, aiding digestion, regulating immune function, lowering blood sugar, and anti-oxidation.

[0030] Phoenix Cloth: sweet, light, neutral. Enters the spleen, stomach, and lung meridians. Has the effects of nourishing yin and clearing the lungs, healing sores, eliminating cataracts, and setting bones. Used for chronic cough and asthma, sore throat and aphonia, lymphatic tuberculosis, ulcers that do not heal, cataracts, dizziness, traumatic fractures, etc. "Bie Lu" says: "It is used to treat chronic cough and qi stagnation. Take ephedra and aster together." "Medical Introduction·Compendium of Materia Medica" says: "(To treat) various sores on the head and body of children, burn ash and pig fat to apply."

[0031] Jade Butterfly: Bitter, sweet, cool in nature. Enters the lung, liver, and stomach meridians. Effects: Clears the lungs and relieves throat, soothes the liver and harmonizes the stomach. It has the effects of clearing lung heat and relieving throat. It is a commonly used medicine for treating lung heat cough, throat paralysis, and hoarseness. "Southern Yunnan Materia Medica": It can calm asthma, eliminate phlegm, break up the accumulation of Gu, and remove the poison of blood Gu and Qi Gu. It can also replenish deficiency, relieve stomachache, and promote eating. "Compilation of Medicinal Materials": It can treat throat aphonia.

[0032] Platycodon grandiflorum: bitter, pungent, neutral in nature. Enters the lung meridian. Efficacy: clearing the lungs, removing phlegm, relieving sore throat, and draining pus. "The Medicinal Properties of Pearl Capsule" states: "Its uses are four: relieving sore throat and removing nasal congestion; relieving diaphragmatic qi and treating lung abscess; one is the boat of all medicines; the other is the guide of the lungs." Pharmacology shows that it has antitussive, anti-inflammatory and immune enhancing effects.

[0033] Sterculia lychnophora: sweet in taste, cold in nature. Enters the lung and large intestine meridians. Efficacy: clears the lungs and resolves phlegm, relieves sore throat and improves voice, moisturizes and relieves bowel movements. Suitable for hoarseness due to lung heat, sore throat, and cough. "Compendium of Materia Medica" says: "It is good at opening and dispersing lung qi, and can vent the skin and fur, and can treat wind evil that is blocked outside, regardless of whether it is cold or hot. It can also open the voice and treat muteness, and relieve cough and eliminate phlegm." Modern research shows that Sterculia lychnophora has a contractile effect on vascular smooth muscle; it can improve mucosal inflammation and relieve spasmodic pain.

[0034] Prunella Vulgaris: pungent, bitter, cold in nature. Enters the liver and gallbladder meridians. Efficacy: clears away heat and purges fire, improves eyesight, dissipates stagnation and reduces swelling. "Shennong's Herbal Classic" says: "It can treat cold and heat, scrofula, fistula, head sores, break up tumors, dissipate gall gas, and swollen and damp feet." Pharmacology shows that it has anti-inflammatory effects.

[0035] Licorice: sweet, neutral in nature. It enters the heart, spleen, lung, and stomach meridians. Efficacy: tonifies the spleen and replenishes qi, eliminates phlegm and relieves cough, relieves acute pain, clears away heat and detoxifies, and harmonizes various medicines. "Famous Doctors' Records" says: "It warms the middle and lowers the qi, relieves fullness and shortness of breath, and coughs caused by damaged organs." "Compendium of Materia Medica" says: "It harmonizes the middle and replenishes qi, and is a medicine for replenishing deficiency and detoxification." Pharmacology shows that it has antitussive, expectorant, and asthma-relieving effects. It has antibacterial, antiviral, anti-inflammatory, and anti-allergic effects, and can protect the inflamed throat and tracheal mucosa; it has an effect similar to adrenocortical hormone.

[0036] The prescription of the present invention corresponds to the syndrome of lung and kidney yin deficiency or qi and yin deficiency, or qi stagnation, blood stasis and phlegm coagulation. "The lung is the gate of voice, the spleen is the basis of voice, and the kidney is the root of voice." Voice comes from the lung and is rooted in the kidney. The lung governs qi, the spleen is the source of qi, and the kidney is the root of qi; the astragalus in the prescription is sweet and slightly warm, enters the lung and spleen meridians, and uses a lot of astragalus to strengthen the spleen and replenish qi, replenish earth and generate gold, the lung and spleen qi are vigorous, and the qi transformation is active, so the voice is clear; the southern adenophora nourishes yin and clears the lungs, replenishes qi and resolves phlegm; the two medicines work together to replenish qi, nourish yin and clear the lungs, and are the main medicines.

[0037] Chinese yam is sweet and mild in taste, and enters the spleen, lung, and kidney meridians. It works with astragalus to invigorate qi and strengthen the spleen, so as to replenish lung qi. Chinese yam is sweet and mild in taste, and enters the spleen, stomach, and lung meridians. It works with Adenophora adenophora to nourish yin and moisten the lungs. Together they are ministerial medicines.

[0038] Jade Butterfly clears lung heat and benefits the throat; Prunella Vulgaris clears heat and relieves depression; Plantago asiatica clears the lungs and resolves phlegm, benefits the throat and improves the voice; the three medicines work together to clear the lungs and eliminate phlegm, clear the lungs and benefit the throat and improve the voice, and they are all adjuvant medicines.

[0039] Platycodon grandiflorum can clear the lungs and relieve sore throat, resolve phlegm and disperse nodules, and carry the medicine upward; licorice can nourish the spleen and replenish qi, resolve phlegm and relieve sore throat, and harmonize various medicines, and they are all adjuvant drugs.

[0040] The combination of these medicines can replenish qi and open the voice, nourish yin and clear the lungs, resolve phlegm and disperse nodules. It can effectively improve symptoms such as vocal cord congestion, hoarseness, dry and painful throat, and dry cough.

[0041] The compatibility characteristics of the present invention are as follows: first, it replenishes the earth to generate gold, strengthens the spleen and nourishes the lungs, and makes the qi transformation active; second, it nourishes yin and clears the lungs, resolves phlegm and disperses knots, and relieves sore throat and relieves voice while replenishing the body, treating both the symptoms and the root causes. After taking the medicine, the qi of the lungs and spleen can be gradually replenished, the virtual fire can be cleared, the knots can be dispersed and phlegm can be resolved, and the throat can be relieved and the voice can be relieved.

[0042] Due to the adoption of the above technical solution, the present invention has the following advantages and beneficial effects:

[0043] The Chinese medicine composition provided by the present invention has the effects of invigorating qi and improving voice, nourishing yin and clearing lungs, resolving phlegm and dispersing nodules, and has the effects of invigorating qi, nourishing yin, clearing lungs, relieving cough, removing phlegm, and relieving sore throat; it can effectively improve symptoms such as vocal cord congestion, hoarseness, dry and painful throat, and dry cough.

[0044] The Chinese medicine composition of the present invention has the effects of nourishing yin and promoting voice, clearing the lungs and replenishing qi, resolving phlegm and dispersing nodules, etc. Currently, there are few Chinese medicine compounds with such effects. DETAILED DESCRIPTION

[0045] In order to explain the present invention more clearly, the present invention is further described below in conjunction with preferred embodiments. It should be understood by those skilled in the art that the following specific description is illustrative rather than restrictive, and should not be used to limit the scope of protection of the present invention.

[0046] Example 1

[0047] A Chinese medicine composition is prepared from the following components:

[0048] 35 parts of Astragalus, 35 parts of Adenophora australis, 35 parts of Dioscorea opposita, 6 parts of Herba Lycopodii, 6 parts of Herba Prunellae, 35 parts of Herba Sterculiae, 25 parts of Platycodon grandiflori, and 15 parts of Radix Glycyrrhizae.

[0049] The preparation of an oral liquid for treating chronic laryngitis using the Chinese medicine composition as a raw material comprises the following steps:

[0050] All the above raw materials are decocted twice with water, the first time for 2 hours and the second time for 1.5 hours, and the filtrates are combined to obtain a primary concentrate; the primary concentrate is placed at room temperature, 95% ethanol is used to prepare a 65% ethanol aqueous solution by volume, the 65% ethanol aqueous solution is added to the primary concentrate, refrigerated at a temperature of 2-10°C for 48 hours, and concentrated under reduced pressure until the concentrate does not contain ethanol, thereby obtaining a secondary concentrate; distilled water is added to the secondary concentrate, refrigerated with water, refrigerated at a temperature of 2-10°C for 48 hours, filtered, the filtrate is collected, 10 parts of white sugar and 2.5 parts of sodium benzoate are added, purified water is added to 1000 ml, the solution is mixed well and filtered, and the solution is boiled and sterilized for 2 hours to obtain an oral solution for treating chronic laryngitis.

[0051] The method of using the oral liquid for treating chronic laryngitis is: oral administration, three times a day, 10 ml each time.

[0052] Example 2

[0053] A Chinese medicine composition is prepared from the following components:

[0054] 30 parts of Astragalus, 30 parts of Adenophora australis, 30 parts of Dioscorea opposita, 5 parts of Herba Lycopodii, 5 parts of Herba Prunellae, 30 parts of Herba Sterculiae, 20 parts of Platycodon grandiflori, and 10 parts of Radix Glycyrrhizae.

[0055] The oral solution was prepared according to the method steps of Example 1.

[0056] Example 3

[0057] A Chinese medicine composition is prepared from the following components:

[0058] 25 parts of Astragalus, 25 parts of Adenophora australis, 25 parts of Dioscorea opposita, 4 parts of Herba Lycopodii, 4 parts of Herba Prunellae, 25 parts of Herba Sterculiae, 15 parts of Platycodon grandiflorum, and 9 parts of Radix Glycyrrhizae.

[0059] The oral solution was prepared according to the method steps of Example 1.

[0060] Example 4

[0061] A Chinese medicine composition is prepared from the following components:

[0062] 20 parts of Astragalus, 20 parts of Adenophora australis, 20 parts of Dioscorea opposita, 3 parts of Herba Lycopodii, 3 parts of Herba Prunellae, 20 parts of Herba Sterculiae, 13 parts of Platycodon grandiflorum, and 6 parts of Radix Glycyrrhizae.

[0063] The oral solution was prepared according to the method steps of Example 1.

[0064] Example 5

[0065] A Chinese medicine composition is prepared from the following components:

[0066] 20 parts of Astragalus, 20 parts of Adenophora australis, 20 parts of Dioscorea opposita, 3 parts of Herba Lycopodii, 3 parts of Herba Prunellae, 20 parts of Herba Sterculiae, 12 parts of Platycodon grandiflorum, and 6 parts of Radix Glycyrrhizae.

[0067] The oral solution was prepared according to the method steps of Example 1.

[0068] Clinical efficacy of the oral liquid for treating chronic laryngitis prepared in Example 1 of the present invention

[0069] 1. Select the patient:

[0070] 100 patients with chronic laryngitis were selected, 50 males and 50 females, aged 18-69 years old, and the oral liquid for treating chronic laryngitis prepared in Example 1 of the present invention was used according to the course of treatment, and patients with other oral diseases were excluded.

[0071] Symptoms of chronic laryngitis: long-term hoarseness, dry and uncomfortable throat, accompanied by cough, expectoration, etc. Laryngoscopy can show dark red congestion, swelling or atrophy of the laryngeal mucosa, thickening and swelling of the vocal cords, poor glottis closure, or thickening of the ventricular zone that covers part of the vocal cords.

[0072] 2. Efficacy criteria: The therapeutic effect is evaluated by the significant reduction of hoarseness or fatigue in pronunciation, sore throat, discomfort, dry cough, significant reduction of vocal cord congestion and hypertrophy or nodules, and good vocal cord closure. It is divided into three criteria: markedly effective, effective, and ineffective.

[0073] (1) Significant effect: hoarseness, fatigue during pronunciation, sore throat, discomfort, and dry cough are significantly relieved, congestion and hypertrophy of the vocal cords or nodules are significantly reduced, and the vocal cords close well;

[0074] (2) Effective: The above symptoms are alleviated, and vocal cord congestion and hypertrophy are reduced;

[0075] (3) Ineffective: There is no improvement in the above symptoms, the vocal cords are still congested and thickened, or there are nodules, or there is incomplete glottal closure.

[0076] 3. Treatment process: Take the oral solution for treating chronic laryngitis prepared in Example 1 of the present invention orally 3 times a day, 10 ml each time. 2 weeks is a course of treatment, and 2 courses of treatment are used. For patients with a long course of disease, the medication time can be appropriately extended, and desserts and spicy foods should be avoided during the treatment period.

[0077] 4. The treatment results are shown in Table 1:

[0078] Table 1

[0079] n Significantly effective% efficient% invalid% Total effective rate% 100 32 51 17 83％

[0080] The total effective rate is the sum of markedly effective and effective. The results in Table 1 show that the oral liquid for treating chronic laryngitis of the present invention can effectively improve the symptoms of chronic pharyngitis in patients.

[0081] Typical Case 1

[0082] Wang, male, 45 years old, teacher. First visit: October 20, 2018. Hoarseness and throat discomfort for more than 10 years, oral antibiotics and Chinese medicine have been used for treatment. Throat discomfort has significantly worsened in the past year, and hoarseness is obvious after talking a lot, and it is difficult to speak in severe cases. Accompanied by shortness of breath, fatigue, dry cough, dry mouth, and night sweats. Examination: scattered hyperplasia of lymph follicles on the posterior pharyngeal wall, diffuse chronic congestion of the mucosa, and dilation and exposure of small blood vessels. Indirect laryngoscopy: moderate hypertrophy of both vocal cords, with nodular protrusions, glottis closure, hyperplasia of the two chambers, and beyond covering the vocal cords. The tongue is pale red, the fur is thin and white, and the pulse is thin. Syndrome differentiation and treatment: the deficiency syndrome is superficial and the phlegm and blood stasis in the larynx are solid, and the deficiency of lung qi and yin is deficiency. The treatment should be to invigorate qi and open the voice, nourish yin and clear the lungs, and resolve phlegm and disperse the knots. The oral liquid for treating chronic laryngitis prepared in Example 1 of the present invention is given. 3 times a day, 10 ml each time, for a total of 2 weeks. Second visit: On October 27, 2018, the oral liquid for treating chronic laryngitis prepared in Example 1 of the present invention was given. 3 times a day, 10 ml each time, for a total of 2 weeks. In the 1-month follow-up, most of the symptoms were eliminated, and there was no hoarseness when speaking for a long time.

[0083] Typical Case 2

[0084] Chen, female, 41 years old, salesperson. First visit: November 17, 2019. Hoarseness and dry cough for more than 4 years, oral Western medicine treatment. Fat, fatigue, dry mouth, poor sleep, slightly hot palms and soles. Examination: diffuse chronic congestion of the throat mucosa, small blood vessel dilation exposed. Indirect laryngoscopy: mild hypertrophy of both vocal cords: no nodules and polyps: glottis closure is leaky, the two chambers are slightly hypertrophic, and they do not exceed the vocal cords. The tongue is slightly red, the fur is thin, and the pulse is stringy and fine. Syndrome differentiation and treatment: this is the deficiency and the superficial syndrome, the laryngeal phlegm and blood stasis are real, and the lung qi and yin are insufficient. It is appropriate to invigorate qi and open the voice, nourish yin and clear the lungs, and resolve phlegm and disperse the knots. The oral liquid for treating chronic laryngitis prepared in Example 1 of the present invention is given. Take 10 ml orally 3 times a day for a total of 2 weeks. Follow-up after 1 month reported that the symptoms of hoarseness, fatigue, and discomfort in the throat were significantly relieved.

[0085] Typical Case 3

[0086] Qian, female, 37 years old, teacher. First visit: September 17, 2020. Long-term speaking is easy to fatigue and accompanied by dry and painful discomfort in the throat for more than 5 years. In the past six months, hoarseness is obvious after talking more, and it is difficult to speak in severe cases. There is dry cough with little sputum and fear of wind. Examination: scattered hyperplasia of lymph follicles on the posterior pharyngeal wall and diffuse chronic congestion of the mucosa. Indirect laryngoscopy shows: moderate hypertrophy of both vocal cords, polyps, glottis closure, hyperplasia of the two chambers, and beyond covering the vocal cords. The tongue is pale red, the fur is thin, and the pulse is thin. Syndrome differentiation and treatment: the deficiency syndrome is superficial and the phlegm and blood stasis in the larynx are solid, and the deficiency of lung qi and yin is deficiency. The treatment should be to invigorate qi and open the voice, nourish yin and clear the lungs, and resolve phlegm and disperse knots. The oral liquid for treating chronic laryngitis prepared in Example 1 of the present invention is given. Take 10 ml orally 3 times a day for a total of 2 weeks. Second visit: On September 30, 2020, the symptoms of hoarseness, fatigue, and pharyngeal discomfort were significantly relieved after talking more, and the oral liquid for treating chronic laryngitis of the present invention was continued. 10 ml was taken orally 3 times a day for a total of 1 week. In the 1-month follow-up, most of the symptoms were eliminated and there was no other discomfort.

[0087] The above is only a preferred embodiment of the present invention, and does not limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment, it is not used to limit the present invention. Any technician familiar with this patent can make some changes or modify the technical contents suggested above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any simple modification, equivalent change and modification made to the above embodiments according to the technical essence of the present invention without departing from the content of the technical solution of the present invention still fall within the scope of the solution of the present invention.

Claims

1. A Chinese medicine composition for treating chronic laryngitis, characterized in that: It is made of the following components in parts by weight: 20-35 parts of Astragalus, 20-35 parts of Adenophora australis, 20-35 parts of Dioscorea opposita, 3-6 parts of Phoenix Cloth, 3-6 parts of Jade Butterfly, 20-35 parts of Prunella Vulgaris, 12-25 parts of Sterculia lychnophora, 12-25 parts of Platycodon grandiflorum, and 6-15 parts of Licorice.

2. The Chinese medicine composition for treating chronic laryngitis according to claim 1, characterized in that: The Chinese medicine composition for treating chronic laryngitis is prepared from the following components in parts by weight: 35 parts of Astragalus, 35 parts of Adenophora australis, 35 parts of Dioscorea opposita, 6 parts of Herba Lycopodii, 6 parts of Herba Prunellae, 35 parts of Herba Sterculiae, 25 parts of Platycodon grandiflori, and 15 parts of Radix Glycyrrhizae.

3. The Chinese medicine composition for treating chronic laryngitis according to claim 1, characterized in that: The Chinese medicine composition for treating chronic laryngitis is prepared from the following components in parts by weight: 30 parts of Astragalus, 30 parts of Adenophora australis, 30 parts of Dioscorea opposita, 5 parts of Herba Lycopodii, 5 parts of Herba Prunellae, 30 parts of Herba Sterculiae, 20 parts of Platycodon grandiflorum, and 10 parts of Radix Glycyrrhizae.

4. The Chinese medicine composition for treating chronic laryngitis according to claim 1, characterized in that: The Chinese medicine composition for treating chronic laryngitis is prepared from the following components in parts by weight: 25 parts of Astragalus, 25 parts of Adenophora australis, 25 parts of Dioscorea opposita, 4 parts of Herba Lycopodii, 4 parts of Herba Prunellae, 25 parts of Herba Sterculiae, 15 parts of Platycodon grandiflorum, and 9 parts of Radix Glycyrrhizae.

5. The Chinese medicine composition for treating chronic laryngitis according to claim 1, characterized in that: The Chinese medicine composition for treating chronic laryngitis is prepared from the following components in parts by weight: 20 parts of Astragalus, 20 parts of Adenophora australis, 20 parts of Dioscorea opposita, 3 parts of Herba Lycopodii, 3 parts of Herba Prunellae, 20 parts of Herba Sterculiae, 13 parts of Platycodon grandiflorum, and 6 parts of Radix Glycyrrhizae.

6. The Chinese medicine composition for treating chronic laryngitis according to claim 1, characterized in that: The Chinese medicine composition for treating chronic laryngitis is prepared from the following components in parts by weight: 20 parts of Astragalus, 20 parts of Adenophora australis, 20 parts of Dioscorea opposita, 3 parts of Herba Lycopodii, 3 parts of Herba Prunellae, 20 parts of Herba Sterculiae, 12 parts of Platycodon grandiflorum, and 6 parts of Radix Glycyrrhizae.

7. A pharmaceutical preparation, characterized in that The invention is prepared from the Chinese medicine composition according to any one of claims 1 to 6.

8. The pharmaceutical preparation according to claim 7, characterized in that The dosage form of the pharmaceutical preparation is oral liquid, tablet, capsule, or pill.

9. Use of the traditional Chinese medicine composition according to any one of claims 1 to 6 in the preparation of a medicament for treating chronic laryngitis.

10. Use of the Chinese medicine composition according to any one of claims 1 to 6 in the preparation of medicines for invigorating qi and promoting voice, medicines for nourishing yin and clearing lungs, and medicines for resolving phlegm and dispersing nodules.