Traditional Chinese medicine composition for reducing blood sugar

Abstract

The application discloses a traditional Chinese medicine composition for reducing blood sugar, which is prepared from the following traditional Chinese medicinal materials in parts by weight: 20-60 parts of Astragalus membranaceus, 10-40 parts of Morus alba, 20-60 parts of Pueraria lobata, 20-50 parts of Polygonatum odoratum, 2-5 parts of bee glue and 2-5 parts of beeswax. The traditional Chinese medicine composition embodies the traditional Chinese medicine theory of syndrome differentiation and treatment, and is skillfully formulated. The traditional Chinese medicine composition plays the role of tonifying qi and nourishing yin and reducing blood sugar, and embodies the unique advantages of traditional Chinese medicine in reducing blood sugar.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine, and more specifically to traditional Chinese medicine compositions having a hypoglycemic effect. Technical Background

[0002] High blood sugar is seen in prediabetes and diabetic patients. Prediabetes is a state of abnormal glucose metabolism, intermediate between normal glucose metabolism and diabetes. It mainly includes three states: impaired fasting glucose, impaired glucose tolerance, and a combination of both. Compared with the general population, people with prediabetes have a significantly higher chance of developing diabetes (25%–48% within 5–10 years). Currently, approximately 148 million people in my country are in the prediabetic stage, i.e., the impaired glucose regulation stage, including impaired fasting glucose and impaired glucose tolerance, with a prevalence rate as high as 15.5%. Diabetes, due to its high incidence of complications and difficulty in treatment, has a certain degree of disability and death, causing great suffering to patients and bringing many negative impacts to their lives. Therefore, the prevention and control of the occurrence and development of diabetes has become an urgent problem to be solved by countries around the world.

[0003] Diabetes falls under the category of "Xiao Ke" in Traditional Chinese Medicine (TCM). Xiao Ke is often caused by improper diet, excessive consumption of rich and fatty foods, which leads to internal heat accumulation, scorching body fluids and depleting Qi; or by improper sexual activity and excessive labor, which depletes kidney essence, generates internal deficiency fire, and ultimately leads to deficiency of both Qi and Yin, resulting in the disease. The "Suwen·Qibing Lun" states: "This is caused by excessive consumption of rich and fatty foods. Such people must frequently eat sweet and fatty foods. Fat causes internal heat, and sweetness causes fullness in the middle, so the Qi overflows upward and turns into Xiao Ke." The "Jinkui Yaolue" says: "When the pulse is rapid and the Yang pulse is weak, there is heat in the stomach, which leads to increased appetite, hard stools, and frequent urination." The "Sanxiao Lun" also points out that "the three types of Xiao Ke share the same dryness and heat."

[0004] Diabetes mellitus is classified into three types: upper, middle, and lower, and these three types often coexist. Upper diabetes mellitus is a syndrome of lung heat damaging body fluids, mostly caused by excessive heat in the lungs and stomach, which consumes body fluids and damages body fluids. Treatment should focus on clearing heat and purging fire, generating body fluids and quenching thirst. Middle diabetes mellitus is a syndrome of intense stomach heat, mostly caused by intense stomach fire, which has a strong ability to digest food and water, consuming body fluids and blood. Treatment should focus on clearing stomach fire, nourishing yin and preserving body fluids. Lower diabetes mellitus is a syndrome of kidney yin deficiency or kidney yang deficiency, mostly caused by inherent yin deficiency, compounded by excessive sexual activity, overexertion, and depletion of yin essence, or yin deficiency affecting yang. It can be seen that although the pathogenesis of the three types of diabetes mellitus is different, they are all the same: yin deficiency and dryness-heat. The disease involves the lungs, spleen, and kidneys, as they are related to the body's fluid metabolism. Insufficient vital energy in the lungs, spleen, and kidneys prevents the distribution of body fluids upwards, hinders their transformation and transportation, and weakens the kidney's function. This leads to symptoms such as thirst, frequent urination, and excessive urination. As the deficiency fire rises, there is increased hunger and overeating. With prolonged illness, yin and yang become imbalanced, and the body's vital energy declines, resulting in qi deficiency, weakness, and lethargy. Therefore, qi and yin deficiency is a common syndrome in diabetes.

[0005] Traditional Chinese medicine (TCM) embodies the characteristics of being people-oriented, tailoring treatment to individual needs, and addressing both the symptoms and root causes of diseases. TCM compound prescriptions have the advantages of syndrome differentiation and treatment, synergistic effects, and fewer side effects, making them acceptable to a wide range of diabetic patients. Summary of the Invention

[0006] The technical problem addressed by this application is to utilize modern scientific and technological equipment and methods to explore the etiology and pathogenesis of diabetes, screen and verify effective drugs, and develop traditional Chinese medicine compositions with proven efficacy, simple dosage forms, and few side effects for obesity caused by deficiency of both Qi and Yin.

[0007] This invention addresses the shortcomings in the prevention and treatment of diabetes, especially diabetes with Qi and Yin deficiency syndrome. Based on the TCM theory of blood sugar reduction and combined with modern pharmacological research, it creatively provides a TCM composition for lowering blood sugar, particularly suitable for diabetes with Qi and Yin deficiency syndrome, which has both symptomatic and root-cause treatment effects.

[0008] One or more embodiments of this application provide a traditional Chinese medicine composition for lowering blood sugar, which is prepared from the following traditional Chinese medicinal materials in parts by weight: 20-60 parts of Astragalus membranaceus (e.g., 30, 40, 50 parts), 10-40 parts of Mulberry leaf (e.g., 20, 30 parts), 20-60 parts of Kudzu root (e.g., 30, 40, 50 parts), 20-50 parts of Polygonatum odoratum (e.g., 30, 40 parts), 2-5 parts of propolis (e.g., 3, 4 parts), and 2-5 parts of beeswax (e.g., 3, 4 parts).

[0009] In one or more embodiments, the traditional Chinese medicine composition is prepared from the following parts by weight of traditional Chinese medicinal materials: 30-50 parts of Astragalus membranaceus, 15-35 parts of mulberry leaves, 30-50 parts of kudzu root, 20-40 parts of Polygonatum odoratum, 2-4 parts of propolis, and 2-4 parts of beeswax.

[0010] In one or more embodiments, the traditional Chinese medicine composition is prepared from the following parts by weight of traditional Chinese medicinal materials: 40 parts of Astragalus membranaceus, 25 parts of mulberry leaves, 40 parts of kudzu root, 30 parts of Polygonatum odoratum, 3 parts of propolis, and 3 parts of beeswax.

[0011] In one or more embodiments, the traditional Chinese medicine composition is prepared by the following method:

[0012] Weighing: Weigh the Chinese medicinal materials according to the above-mentioned weight proportions;

[0013] Extraction: Soak Astragalus membranaceus, Pueraria lobata, mulberry leaves and Polygonatum odoratum in water for 1 hour, decoct twice, 1 hour each time. Add 12 times the amount of water for the first decoction and 10 times the amount of water for the second decoction. Filter and combine the extracts.

[0014] Concentration: The above filtrate is concentrated under reduced pressure to a thick paste at a temperature of 60-70℃ and a vacuum degree of -0.03 to -0.08 MPa;

[0015] Drying: The thick paste is spray-dried to obtain a dry paste powder;

[0016] Mixing: After passing propolis and beeswax through an 80-mesh sieve, mix them with the dry ointment powder to obtain the traditional Chinese medicine composition powder.

[0017] One or more embodiments of this application provide a method for preparing the traditional Chinese medicine composition of this application, which includes:

[0018] Weighing: Weigh the Chinese medicinal materials according to the above-mentioned weight proportions;

[0019] Extraction: Soak Astragalus membranaceus, Pueraria lobata, mulberry leaves and Polygonatum odoratum in water for 1 hour, decoct twice, 1 hour each time. Add 12 times the amount of water for the first decoction and 10 times the amount of water for the second decoction. Filter and combine the extracts.

[0020] Concentration: The above filtrate is concentrated under reduced pressure to a thick paste at a temperature of 60-70℃ and a vacuum degree of -0.03 to -0.08 MPa;

[0021] Drying: The thick paste is spray-dried to obtain a dry paste powder;

[0022] Mixing: After passing propolis and beeswax through an 80-mesh sieve, mix them with the dry ointment powder to obtain the traditional Chinese medicine composition powder.

[0023] One or more embodiments of this application provide traditional Chinese medicine preparations comprising the traditional Chinese medicine composition and excipients of this application.

[0024] In one or more embodiments, the excipient in the traditional Chinese medicine preparation is D-mannitol.

[0025] In one or more embodiments, the traditional Chinese medicine preparation is prepared as powder, tea, granules, pills, powder, tablets, capsules or oral liquid.

[0026] One or more embodiments of this application provide the use of the traditional Chinese medicine composition or preparation of this application in the preparation of drugs, health foods and functional foods for the prevention or treatment of diabetes.

[0027] In one or more embodiments, the diabetes is a type of diabetes with both Qi and Yin deficiency and related diseases.

[0028] Astragalus is the dried root of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge., both belonging to the Fabaceae family.

[0029] Mulberry leaves are the dried leaves of the mulberry tree (Morus alba L.) belonging to the Moraceae family.

[0030] Kudzu root is the dried root of Pueraria lobata (Willd.) Ohwi or Pueraria thomsonii Benth., both belonging to the legume family.

[0031] Polygonatum odoratum (Mill.) Druce is the dried rhizome of the plant Polygonatum odoratum (Mill.) Druce, belonging to the Liliaceae family.

[0032] Propolis is a sticky, solid, viscous substance formed by worker bees of the Italian honeybee (Apis mellifera L.) collecting plant resins and mixing them with secretions from their mandibular and wax glands.

[0033] Beeswax is the wax secreted by the honeybee Apis cerana Fabricius (Chinese honeybee) or Apis mellifera Linnaeus (Italian honeybee).

[0034] In one or more embodiments, the traditional Chinese medicine composition of this application is suitable for people with diabetes of the Qi and Yin deficiency type, and has the effects of invigorating Qi, nourishing Yin and quenching thirst.

[0035] In one or more embodiments, the term "multiple amount" as used in this application specification refers to the ratio of the volume (mL) of water added to the weight (g) of the extracted medicinal material.

[0036] The technical solution of this application has at least one of the following beneficial technical effects:

[0037] This application presents a traditional Chinese medicine composition applicable to diabetes, particularly diabetes with both Qi and Yin deficiency. It is suitable for symptoms such as excessive thirst and drinking, polyphagia and loose stools, emaciation, polyuria, lethargy, and weakness in the limbs. Other symptoms may include reduced appetite, a pale red tongue with a dry white coating, and a weak pulse. Diabetes is often caused by diet and emotional factors. The initial understanding of its pathogenesis as Yin deficiency as the root cause and dryness and heat as the manifestation has gradually expanded to the current understanding centered on the spleen and stomach. Fluctuations in blood sugar levels in diabetic patients are closely related to diet and the function of the spleen and stomach. The *Suwen* (Plain Questions) states, "Food enters the stomach, where it circulates and releases Qi, which is then transported upwards to the spleen…", indicating that the spleen and stomach are crucial for the distribution of food. Long-term overconsumption of rich and greasy foods can lead to dysfunction of the spleen and stomach, causing food to accumulate in the middle Jiao (middle burner), eventually resulting in internal heat and phlegm. In the prediabetic stage, individuals may have a constitution prone to Yin deficiency, excessive liver fire damaging Qi and Yin, or a deficiency of spleen Qi leading to Qi stagnation, blood stasis, and further Yin depletion. Although the starting points differ, they ultimately progress to Qi and Yin deficiency, making it a crucial point in the progression to the full stage of diabetes. This application addresses the etiology and pathogenesis of diabetes by tonifying Qi and strengthening the spleen, nourishing Yin and generating fluids, thus addressing both the root cause and symptoms to achieve a blood sugar-lowering effect.

[0038] The hypoglycemic traditional Chinese medicine composition of this application closely addresses the key pathogenesis of diabetes mellitus characterized by deficiency of both Qi and Yin. It is based on tonifying Qi and nourishing Yin, replenishing Qi and raising Yang, promoting body fluid production and quenching thirst, thus simultaneously tonifying both Qi and Yin. It replenishes Qi without causing stagnation and nourishes Yin without being cold in nature. There are no contraindications for its formulation; they complement each other. It effectively exerts its hypoglycemic function.

[0039] The traditional Chinese medicine compositions in this application are all derived from the same source as food and can be used in medicines, health foods, and functional foods for the prevention and treatment of diabetes and related diseases.

[0040] This traditional Chinese medicine composition embodies the TCM theory of "differentiation of syndromes and treatment based on syndrome differentiation." The ingenious formula is designed for people with diabetes of the Qi and Yin deficiency type, and plays a role in replenishing Qi, nourishing Yin and lowering blood sugar, demonstrating the unique advantage of TCM in "differentiation of syndromes and lowering blood sugar." Detailed Implementation

[0041] To make the objectives, technical solutions, and advantages of the present invention clearer, the technology of the present invention will be further described in detail through the following specific embodiments. It should be understood that the embodiments included in the present invention are not limited to the following embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0042] Preparation Example 1

[0043] Take 40 parts Astragalus membranaceus, 25 parts Mulberry leaves, 40 parts Kudzu root, 30 parts Polygonatum odoratum, 3 parts propolis, and 3 parts beeswax. Soak all herbs except propolis and beeswax in purified water for 1 hour. First, add 12 times the amount of water and decoct for 1 hour, then filter to obtain the filtrate. Second, add 10 times the amount of water and decoct for 1 hour, then filter again to obtain the filtrate. Combine the two filtrates. Concentrate the filtrate under reduced pressure (temperature 60-70℃, vacuum degree -0.03~-0.08MPa) to obtain a thick paste, then spray dry to obtain a dry powder of the herbal composition. Mix the dry powder with propolis powder and beeswax evenly, add D-mannitol and mix evenly to prepare a 6g / bag powder.

[0044] Preparation Example 2

[0045] Take 40 parts Astragalus membranaceus, 25 parts Mulberry leaves, 40 parts Kudzu root, 30 parts Polygonatum odoratum, 3 parts propolis, and 3 parts beeswax. Soak all herbs except propolis and beeswax in purified water for 1 hour. First, add 12 times the amount of water and decoct for 1 hour, then filter to obtain the filtrate. Second, add 10 times the amount of water and decoct for 1 hour, then filter again to obtain the filtrate. Combine the two filtrates. Concentrate the resulting filtrate under reduced pressure (temperature 60-70℃, vacuum degree -0.03~-0.08MPa) to obtain a thick paste, then spray-dry to obtain a dry powder of the herbal composition. Mix the dry powder with propolis powder and beeswax evenly, add D-mannitol and mix evenly, then dry granulate to produce 6g / bag granules.

[0046] Preparation Example 3

[0047] Take 40 parts of Astragalus membranaceus, 25 parts of mulberry leaves, 40 parts of kudzu root, 30 parts of Polygonatum odoratum, 3 parts of propolis, and 3 parts of beeswax. Soak all the herbs except propolis and beeswax in purified water for 1 hour. First, add 12 times the amount of water and decoct for 1 hour, then filter to obtain the filtrate. Second, add 10 times the amount of water and decoct for 1 hour, then filter again to obtain the filtrate. Combine the two filtrates. Concentrate the resulting filtrate under reduced pressure (temperature 60-70℃, vacuum degree -0.03~-0.08MPa) to obtain a thick paste, then spray dry to obtain a dry powder of the herbal composition. Mix the dry powder with propolis powder and beeswax evenly, add D-mannitol and mix evenly, then dry granulate, compress into tablets, and make 1g / tablet.

[0048] Example 4: The effect of the traditional Chinese medicine composition of this application on invigorating qi, nourishing yin, and lowering blood sugar in diabetic rats with qi and yin deficiency.

[0049] Male SD rats weighing 200±20g were acclimatized for 7 days and then fasted overnight for 12 hours. Blood glucose levels were measured by taking tail vein blood using a portable blood glucose meter. The blood glucose level was measured before glucose administration (i.e., 0 hours) and at 0.5 hours and 2 hours after administration of glucose at 2.5g / kg BW. These values ​​were used as the baseline values ​​for this batch of animals.

[0050] The animals were divided into 6 groups based on their blood glucose levels at 0 hours and 0.5 hours: blank group, model group, positive drug group (control drug was Shiwei Xiaoke capsules), high-dose group of Example 1, medium-dose group of Example 1, and low-dose group of Example 1. Each group consisted of 8 animals. The gavage volume was 1 mL / 100 g, and the animals were gavaged once a day. The blank group was gavaged with physiological saline. The treatment was continued for 30 days.

[0051] After 7 days of adaptive feeding, modeling began, and the modeling period lasted for 30 days: (1) During the first week, each group was fed maintenance feed. After one week, the model group, positive drug group, and the high, medium, and low dose groups of Example 1 were fed high-energy feed for 3 weeks. (2) Subcutaneous injection of T4: T4 suspension (0.2 mg / kg) was injected subcutaneously into the upper neck at 14:00 on days 17-23 of modeling. (3) After the T4 injection on day 23 of modeling, the model group, positive drug group, and the high, medium, and low dose groups of Example 1 were fasted for 20 hours (water was not prohibited). On day 24 of modeling, a single intraperitoneal injection of 2% STZ solution (30 mg / kg) was given (prepared fresh, take an appropriate amount of STZ, and store it in ice in the dark with tin foil. Prepare the solution in an ice bath with 0.1 mol / L citrate-sodium citrate buffer, pH=4.5). After the injection, the high-energy feed was continued for 5 days, and the experiment ended. Twelve hours after the last gavage administration, rats in each group were fasted but allowed free access to water. Two hours before sampling, rats were weighed and anesthetized with an intraperitoneal injection of 1% sodium pentobarbital. Blood was collected from the abdominal aorta, allowed to stand at room temperature for 1-2 hours, and then centrifuged at 3500 rpm for 15 minutes. Serum was separated, and the supernatant was collected and stored at low temperature (4℃) for later analysis. The skin and muscles of the rat's abdomen were dissected with surgical scissors, and the rat's liver was removed and placed in a fixative solution. The thymus and spleen were also removed and weighed.

[0052] Experimental Results: As shown in Table 1, after 30 days of administration, compared with the blank group, the fasting blood glucose of rats in the Qi and Yin deficiency type diabetic model group was significantly increased (P<0.01). Compared with the Qi and Yin deficiency type diabetic model group, the fasting blood glucose of rats in the positive drug group was significantly decreased (P<0.01), and the FBG of the high, medium and low dose groups in Example 1 was significantly decreased, with statistically significant differences (P<0.01, P<0.05); see Table 1. This indicates that the traditional Chinese medicine composition of this application has hypoglycemic effect.

[0053] Table 1. Statistical results of fasting blood glucose in rats of each group ( n=8)

[0054]

[0055] Note: Compared with the blank group * P<0.05, ** P<0.01; compared with the model group, # P<0.05, ## P<0.01; compared with the positive drug group (Ten-Ingredient Diabetes Mellitus Group) △ P < 0.05

[0056] Compared with the control group, the GHbA1c of rats in the Qi and Yin deficiency type hyperglycemia model group was significantly increased and FINS was significantly decreased, with statistically significant differences (P<0.01). Compared with the Qi and Yin deficiency type hyperglycemia model group, the GHbA1c of rats in the positive drug group was significantly decreased and FINS was significantly increased, with statistically significant differences (P<0.01). In Example 1, the low, medium, and high dose groups showed significantly decreased GHbA1c and significantly increased FINS, with statistically significant differences (P<0.01); see Table 2. This indicates that the traditional Chinese medicine composition of this application has hypoglycemic effect.

[0057] Table 2. Statistical results of GHbA1c and FINS in rats of each group ( n=8)

[0058]

[0059] Note: Compared with the blank group * P<0.05, ** P<0.01; compared with the model group, # P<0.05, ## Compared with the blank group, the cAMP level in the Qi and Yin deficiency type hyperglycemia model group was significantly increased, cGMP level was significantly decreased, and cAMP / cGMP ratio was significantly increased (P<0.01). Compared with the Qi and Yin deficiency type hyperglycemia model group, the cAMP level in the positive control group was significantly decreased, cGMP level was significantly increased, and cAMP / cGMP ratio was significantly decreased (P<0.01). In Example 1, the low, medium, and high dose groups showed significantly decreased cAMP levels, significantly increased cGMP levels, and significantly decreased cAMP / cGMP ratio (P<0.01); see Table 3. This indicates that the traditional Chinese medicine composition of this application has the effect of relieving Yin deficiency syndrome in rats with Qi and Yin deficiency.

[0060] Table 3. Statistical results of cAMP, cGMP, and cAMP / cGMP in each group of rats ( n=8)

[0061]

[0062] Note: Compared with the blank group * P<0.05, ** P<0.01; compared with the model group, # P<0.05, ## P<0.01; compared with the positive drug group △ P < 0.05

[0063] Compared with the control group, the spleen index, thymus index, and grip strength of rats in the Qi and Yin deficiency hyperglycemia model group were significantly decreased (P<0.01). Compared with the Qi and Yin deficiency hyperglycemia model group, the spleen index of rats in the positive drug group was significantly increased (P<0.01), and the spleen index of the high, medium, and low dose groups in Example 1 was significantly increased (P<0.01), which was statistically significant; see Table 4. This indicates that the traditional Chinese medicine composition of this application has the effect of invigorating Qi.

[0064] Table 4. Statistical results of spleen index, thymus index, and grip strength of rats in each group. n=8)

[0065]

[0066] Note: Compared with the blank group * P<0.05, ** P<0.01; compared with the model group, # P<0.05, ## P<0.01.

Claims

1. A traditional Chinese medicine composition for treating diabetes mellitus of the Qi and Yin deficiency type, which is prepared from the following traditional Chinese medicinal materials in parts by weight: Astragalus membranaceus 30-50 parts, mulberry leaf 15-35 parts, kudzu root 30-50 parts, Polygonatum odoratum 20-40 parts, propolis 2-4 parts, and beeswax 2-4 parts.

2. The traditional Chinese medicine composition as described in claim 1 is prepared from the following traditional Chinese medicinal materials in parts by weight: 40 parts of Astragalus membranaceus, 25 parts of mulberry leaf, 40 parts of kudzu root, 30 parts of Polygonatum odoratum, 3 parts of propolis, and 3 parts of beeswax.

3. The traditional Chinese medicine composition according to any one of claims 1-2, wherein it is prepared by the following method: Weighing: Weigh the Chinese medicinal materials according to their weight proportions; Extraction: Soak Astragalus membranaceus, Pueraria lobata, mulberry leaves and Polygonatum odoratum in water for 1 hour, decoct twice, 1 hour each time. Add 12 times the amount of water for the first decoction and 10 times the amount of water for the second decoction. Filter and combine the extracts. Concentration: The filtrate is concentrated under reduced pressure to a thick paste at a temperature of 60-70℃ and a vacuum degree of -0.03~-0.08MPa; Drying: The thick paste is spray-dried to obtain a dry paste powder; Mixing: After passing propolis and beeswax through an 80-mesh sieve, mix them with the dry ointment powder to obtain the traditional Chinese medicine composition powder.

4. A method for preparing the traditional Chinese medicine composition according to any one of claims 1-3, comprising: Weighing: Weigh the medicinal materials according to the weight proportions specified in any one of claims 1-2; Extraction: Soak Astragalus membranaceus, Pueraria lobata, mulberry leaves and Polygonatum odoratum in water for 1 hour, decoct twice, 1 hour each time. Add 12 times the amount of water for the first decoction and 10 times the amount of water for the second decoction. Filter and combine the extracts. Concentration: The filtrate is concentrated under reduced pressure to a thick paste at a temperature of 60-70℃ and a vacuum degree of -0.03~-0.08MPa; Drying: The thick paste is spray-dried to obtain a dry paste powder; Mixing: After passing propolis and beeswax through an 80-mesh sieve, mix them with the dry ointment powder to obtain the traditional Chinese medicine composition powder.

5. A traditional Chinese medicine preparation for treating diabetes mellitus of the Qi and Yin deficiency type, comprising the traditional Chinese medicine composition and excipients as described in any one of claims 1-3.

6. The traditional Chinese medicine preparation according to claim 5, wherein the excipient is D-mannitol.

7. The traditional Chinese medicine preparation as described in claim 5, which is prepared as powder, tea, granules, pills, powder, tablets, capsules or oral liquid.

8. Use of the traditional Chinese medicine composition according to any one of claims 1-3 or the traditional Chinese medicine preparation according to any one of claims 5-7 in the preparation of a medicament for the prevention or treatment of diabetes.

9. The use as described in claim 8, wherein the diabetes is a type of diabetes with both Qi and Yin deficiency.

10. Use of the traditional Chinese medicine composition according to any one of claims 1-3 or the traditional Chinese medicine preparation according to any one of claims 5-7 in the preparation of health food for regulating blood sugar.

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