Immunity-regulating electuary containing composite plant powder and preparation process of immunity-regulating electuary

Abstract

The invention belongs to the technical field of solid instant drinks, and particularly relates to a composite plant powder-containing electuary for regulating immunity and a preparation process of the electuary. By screening different combinations of medicinal and edible materials with the effect of regulating immunity, the medicinal and edible plant composite powder with a good effect of regulating immunity is obtained, and the medicinal and edible plant composite powder comprises the radix puerariae powder, the rhizoma polygonati powder, the kelp powder, the agastache rugosus powder, the gordon euryale seed powder and the liquorice powder, is low in cost, contains less pure medicine components, and is suitable for being used as a medicinal and edible food. The traditional Chinese medicine composition can be taken for a long time, has small influence on the body and is suitable for large-area popularization and application.

Description

Technical Field

[0001] The invention belongs to the technical field of solid instant drink, and in particular relates to an immunity regulating instant drink containing composite plant powder and a preparation process thereof. Background Art

[0002] As the pace of modern life accelerates, people are facing more and more health challenges, among which immunity issues are becoming more and more prominent, becoming a key factor affecting the quality of life and physical health. Immunity is not only the first line of defense for the human body to defend against the invasion of foreign pathogens, but also an important mechanism for maintaining the stability of the internal environment, removing abnormal cells, and preventing the occurrence of chronic diseases.

[0003] Modern immunology believes that immunity is the body's own defense mechanism, which is the body's ability to identify and eliminate any foreign bodies (viruses, bacteria, etc.) that invade from outside, deal with aging, damage, death, degeneration of its own cells, and identify and deal with mutant cells and virus-infected cells in the body. The most direct manifestation of low immunity is that the body consumes energy too quickly, with symptoms such as physical weakness, fatigue, susceptibility to colds, mental depression, decreased appetite, chest tightness and shortness of breath, back pain, insomnia, and premature aging. In the long run, it will lead to physical and intellectual stunting, and it is also easy to induce major diseases, such as cardiovascular and cerebrovascular diseases, diabetes, hypertension, hyperlipidemia, fatty liver, obesity, and even cancer. Therefore, how to effectively improve and regulate immunity to enhance the body's resistance and prevent diseases has become a core issue in public health awareness.

[0004] In recent years, with the continuous advancement of science and technology, people are constantly updating methods and means for regulating immunity. Among them, regulating immunity through diet and traditional Chinese medicine is considered to be a safe and effective way. However, there are many kinds of Chinese medicine compositions for regulating immunity on the market, but most of them have problems such as unclear effect, poor taste, and inconvenience in use. Therefore, developing a Chinese medicine composition that can effectively regulate human immunity and has good taste and is easy to use has become a technical problem that technicians in this field urgently need to solve. Summary of the invention

[0005] In order to solve the above problems, the present invention provides an immunity regulating granule containing a composite plant powder, wherein the composite plant powder comprises kudzu root powder, polygonatum sibiricum powder, kelp powder, patches powder, euryale powder and liquorice powder.

[0006] Furthermore, the composite plant powder comprises 17-23 parts of kudzu root powder, 6-12 parts of polygonatum powder, 15-20 parts of kelp powder, 12-18 parts of patchouli powder, 10-15 parts of euryale powder and 8-13 parts of liquorice powder by weight.

[0007] Furthermore, the composite plant powder comprises 18 parts of kudzu root powder, 10 parts of polygonatum powder, 16 parts of kelp powder, 15 parts of patchouli powder, 12 parts of euryale powder and 9 parts of liquorice powder by weight.

[0008] Furthermore, the composite plant powder also contains one or more of oatmeal powder, black bean powder, pea powder, black rice powder and buckwheat powder.

[0009] Furthermore, the composite plant powder further comprises, by weight, 0-10 parts of oatmeal powder, 0-15 parts of black bean powder, 0-10 parts of pea powder, 0-20 parts of black rice powder and 0-15 parts of tartary buckwheat powder.

[0010] Furthermore, the composite plant powder also contains 8 parts of oatmeal powder, 13 parts of black bean powder, 5 parts of pea powder, 18 parts of black rice powder and 11 parts of tartary buckwheat powder by weight.

[0011] The present invention also provides a method for preparing the immunity regulating granules as described herein, which comprises the following steps: respectively selecting Pueraria root, Polygonatum sibiricum, Kelp, Patchouli, Euryale ferox and Licorice, washing, drying, crushing and sieving them, then mixing the ingredients according to the required weight parts and mixing them evenly to obtain the immunity regulating granules.

[0012] Furthermore, the weight proportions used in the mixing of ingredients are 17-23 parts of kudzu root powder, 6-12 parts of polygonatum powder, 15-20 parts of kelp powder, 12-18 parts of patchouli powder, 10-15 parts of euryale powder and 8-13 parts of liquorice powder.

[0013] Furthermore, the preparation method also includes selecting one or more of oats, black beans, peas, black rice and bitter buckwheat as additional raw materials.

[0014] Furthermore, when preparing the ingredients, the additional raw materials are used in the following weight proportions: 0-10 parts of oat flour, 0-15 parts of black bean flour, 0-10 parts of pea flour, 0-20 parts of black rice flour and 0-15 parts of buckwheat flour.

[0015] Beneficial effects of the present invention: The present invention obtains a medicinal and edible plant composite powder with better immune-regulating effect by screening different combinations of medicinal and edible materials with immune-regulating effect. The composite powder has low cost, contains less pure drug ingredients, can be taken for a long time, has little impact on the body, and is suitable for large-scale promotion and application.

[0016] The effects of the components in the plant composite powder selected by the present invention are as follows.

[0017] Pueraria root: It mainly contains isoflavones (puerarin, daidzein), triterpenes (pueraria saponin A, pueraria saponin B methyl ester), coumarins (coumarinol, pueraria phenol), alkaloids (5-methylhydantoin, allantoin), carbohydrates (pueraria polysaccharide), amino acids, minerals (K, Zn, Fe) and other ingredients. It has the effects of lowering blood lipids, blood pressure, blood sugar, protecting against brain damage, protecting the liver, sobering up, lowering uric acid, anti-oxidation, anti-aging, and enhancing immunity.

[0018] Polygonatum: It mainly contains carbohydrates (polysaccharides, oligosaccharides), saponins (diosgenin, diosgenin), lignin, flavonoids, alkaloids, quinones, amino acids and other ingredients. It has the effects of lowering blood lipids, lowering blood sugar, anti-aging, anti-tumor, regulating immunity, and improving memory.

[0019] Kelp: It has the effects of eliminating phlegm, softening and dispersing nodules, promoting diuresis and reducing swelling. By gavage of mice with kelp polysaccharide, the average weight of mice irradiated with radiation can be increased, and the white blood cell content in peripheral blood can be increased, proving that kelp polysaccharide can resist radiation. Experiments on mice also proved that kelp polysaccharide can very obviously counteract the inhibitory effect of radiation on related immune indicators, and has a certain antagonistic effect on irradiation-induced apoptosis of rat spleen lymphocytes. One of the possible mechanisms of its anti-radiation effect is to up-regulate the expression of apoptosis-inhibiting gene Bcl-2 and down-regulate the expression of pro-apoptosis gene Bax protein, and the Bcl-2 / Bax ratio is significantly increased, which prevents apoptosis of spleen lymphocytes and promotes the recovery of immune function. The anti-radiation effect and mechanism of kelp polysaccharide were explored, and it was found that one of the possible mechanisms of its anti-radiation effect is to inhibit the apoptosis of immune cells.

[0020] Patchouli: Nature and flavor: pungent, slightly warm. It enters the spleen, stomach, and lung meridians. Efficacy: dehumidification, heat relief, and nausea relief. Patchouli's main active ingredients, such as patchouli alcohol and patchouli ketone, have a wide range of antiviral effects. Patchouli alcohol has a good inhibitory effect on H1N1, H2N2, Ad3, and CVB3 viruses, and patchouli essential oil has a good inhibitory effect on RSV, AQV, and CV-B3 viruses.

[0021] Gorgon Fruit: It is rich in nutrients, such as starch, protein, vitamins, and mineral elements. It also contains a variety of biologically active substances, such as polysaccharides, polyphenols, glycolipid compounds, cyclic peptide compounds, etc. Modern medical research has further found that Gorgon Fruit has a variety of biological functional activities, such as anti-oxidation, free radical scavenging, anti-fatigue, blood sugar reduction, improvement of local anemia and damage of myocardium, treatment of kidney disease, antibacterial, prevention of gastric mucosal damage, improvement of brain learning and memory disorders, anti-fatigue, anti-melanin synthesis, blood lipid reduction, anti-aging, inhibition of cancer cell proliferation, protection of nerve cells, and treatment of diabetes.

[0022] Licorice: Flavonoids are the main active ingredients of licorice, among which liquiritin is one of the important monomer components of flavonoids. Licorice extracts were obtained by water extraction and alcohol precipitation and alcohol extraction and water precipitation, and their radiation protection effects were tested. The results showed that oral administration of 75% alcohol total extract of licorice had a significant protective effect on mice with different radiation doses. The effect of licorice on the skin of hairless mice after ultraviolet irradiation was studied, and the results showed that licorice flavonoids can protect the skin, delay skin photoaging, and increase collagen content. At high doses, liquiritin can significantly inhibit the production of micronuclei in human peripheral blood lymphocytes caused by 60 Co-γ-ray radiation in vitro, and has a protective effect.

[0023] Oats: Mainly contain dietary fiber (β-glucan), flavonoids (quercetin, kaempferol), phenolic acids (ferulic acid and its derivatives), saponins, alkaloids, protein, fat and other ingredients. It has the functions of nutrition, regulating blood lipids, lowering blood sugar, lowering cholesterol, regulating insulin levels, improving large intestine function, anti-oxidation, antibacterial, anti-inflammatory and antipruritic, anti-tumor, anti-caries, improving immunity, regulating sports fatigue or skeletal muscle metabolism, improving blood microcirculation, and enhancing memory and thinking ability.

[0024] Black beans: mainly contain flavonoids (flavonoids, isoflavones, flavonols, dihydroflavonoids, flavanones, etc.), proteins (salt-soluble globulins, antibacterial proteins, chitinase, SOD, POD, anti-nutritional factors), red pigments (anthocyanins), saponins (pentacyclic triterpenoid oleanolic acid total glycosides), distilled oil, polysaccharides, fatty acids and other ingredients. It has nutritional, antioxidant, anti-tumor, prevention of cardiovascular diseases, antiviral, anti-inflammatory, antibacterial, blood sugar lowering, vision improvement, prevention of arteriosclerosis, anti-HIV, liver protection, antipruritic and anti-inflammatory, treatment of skin diseases, and immunity regulation.

[0025] Pea: Mainly contains pea protein, pea polypeptide, pea starch, dietary fiber, trypsin inhibitor (13 subtypes, mainly A1 and A2 subunits), phenols (flavonoids, phenolic acids, tannins and anthocyanins and their derivatives) and other ingredients. It has the effects of enhancing human immunity, preventing cardiovascular and cerebrovascular diseases, removing excess free radicals from the human body, preventing cancer, delaying aging, lowering blood sugar, lowering cholesterol, improving colon function, preventing colon cancer, cardiovascular disease, diabetes, anti-inflammatory, anti-radiation, anti-disease and anti-insect, and anti-virus.

[0026] Black rice: It mainly contains anthocyanins, flavonoids, phenolic acids (protocatechuic acid, ferulic acid, vanillic acid), γ-aminobutyric acid, fats (unsaturated fatty acids, oleic acid and linoleic acid), dietary fiber and other ingredients. It has nutritional, antioxidant, lipid-lowering, blood pressure-lowering, blood sugar regulating, liver protection, nerve protection, anti-tumor, promotion of the proliferation of probiotic flora, antibacterial, anti-allergic, anti-asthma, anti-inflammatory and hemostatic, immunity-enhancing, mood adjustment, sleep improvement, brain strengthening, liver and kidney protection, and weight loss effects.

[0027] Buckwheat: It mainly contains buckwheat oil (oleic acid, linoleic acid, carotenoids, tocopherol), protein / peptide (albumin, glutenin, alcohol-soluble protein, globulin, lysine), flavonoids (rutin, quercetin), starch, polysaccharides, phenolic acids (protocatechuic acid, ferulic acid, parahydroxybenzoic acid) and other ingredients. It has antioxidant, prevention and treatment of lipid metabolism disorders, protection of the liver and atherosclerosis, anti-aging, anti-fatigue, lowering blood sugar, improving constipation, inhibiting colorectal cancer and gallstones, anti-edema, antibacterial, anti-tumor, lowering blood lipids, anti-inflammatory and antipruritic, and promoting brain protein kinase activity. It can be used as a high-quality source of dietary tocopherol. DETAILED DESCRIPTION

[0028] The present invention is further described below with reference to specific examples, but the examples do not limit the present invention in any form. Unless otherwise specified, the reagents, methods and equipment used in the present invention are conventional reagents, methods and equipment in the art.

[0029] Example 1 The invention discloses an immunity regulating granule containing composite plant powder, which comprises, by weight, 18 parts of kudzu root powder, 10 parts of polygonatum powder, 16 parts of kelp powder, 15 parts of patchouli powder, 12 parts of euryale powder and 9 parts of liquorice powder.

[0030] The preparation method of the immunity regulating granules containing composite plant powders is as follows: Pueraria root, Polygonatum sibiricum, Kelp, Patchouli, Euryale ferox and Licorice are selected respectively, washed, dried, crushed and passed through a 100-mesh sieve to obtain their respective powders, and then Pueraria root powder, Polygonatum sibiricum powder, Kelp powder, Patchouli powder, Euryale ferox powder and Licorice powder are evenly mixed according to the required weight parts to obtain the granules.

[0031] Example 2 An immunity regulating granule containing composite plant powder comprises 20 parts of kudzu root powder, 7 parts of polygonatum powder, 19 parts of kelp powder, 16 parts of patchouli powder, 14 parts of euryale powder and 11 parts of liquorice powder by weight. The preparation method is the same as that of Example 1.

[0032] Example 3 The invention discloses an immunity regulating granule containing composite plant powder, which comprises, by weight, 18 parts of kudzu root powder, 10 parts of polygonatum powder, 16 parts of kelp powder, 15 parts of patchouli powder, 12 parts of euryale powder, 9 parts of liquorice powder, 8 parts of oatmeal powder, 13 parts of black bean powder, 5 parts of pea powder, 18 parts of black rice powder and 11 parts of tartary buckwheat powder.

[0033] The preparation method of the immunity regulating granules containing composite plant powders is as follows: respectively selecting kudzu root, polygonatum, kelp, patchouli, euryale, licorice, oats, black beans, peas, black rice and tartary buckwheat, washing, drying, crushing and passing through a 100-mesh sieve to obtain their respective powders, and then evenly mixing kudzu root powder, polygonatum powder, kelp powder, patchouli powder, euryale powder, licorice powder, oat powder, black bean powder, pea powder, black rice powder and tartary buckwheat powder according to the required weight parts to obtain the granules.

[0034] Comparative Example 1 An immunity regulating granule containing composite plant powder comprises 18 parts of kudzu root powder, 10 parts of tuckahoe powder, 16 parts of wolfberry powder, 15 parts of patchouli powder, 12 parts of euryale powder and 9 parts of liquorice powder by weight. The preparation method is the same as that of Example 1.

[0035] Comparative Example 2 An immunity regulating granule containing composite plant powder comprises 18 parts of kudzu root powder, 10 parts of polygonatum powder, 16 parts of tuckahoe powder, 15 parts of wolfberry powder, 12 parts of euryale powder and 9 parts of liquorice powder by weight. The preparation method is the same as that of Example 1.

[0036] Comparative Example 3 An immunity regulating granule containing composite plant powder comprises, by weight, 18 parts of astragalus powder, 10 parts of atractylodes powder, 16 parts of kelp powder, 15 parts of patchouli powder, 12 parts of yam powder and 9 parts of liquorice powder.

[0037] Comparative Example 4 An immunity regulating granule containing composite plant powder comprises, by weight, 18 parts of kudzu root powder, 10 parts of polygonatum powder, 16 parts of kelp powder, 15 parts of notoginseng powder, 12 parts of hovenia dulcis powder, 10 parts of polygonatum powder and 9 parts of liquorice powder.

[0038] Comparative Example 5 The invention discloses an immunity regulating granule containing composite plant powder, which comprises, by weight, 18 parts of kudzu root powder, 10 parts of polygonatum powder, 16 parts of kelp powder, 15 parts of codonopsis powder, 12 parts of astragalus powder and 9 parts of polygonatum powder.

[0039] Comparative Example 6 An immunity regulating granule containing composite plant powder comprises, by weight, 18 parts of kudzu root powder, 10 parts of polygonatum powder, 15 parts of patchouli powder, 12 parts of euryale powder and 9 parts of liquorice powder.

[0040] Comparative Example 7 The invention discloses an immunity regulating granule containing composite plant powder, which comprises, by weight, 18 parts of kudzu root powder, 10 parts of polygonatum powder, 16 parts of kelp powder, 12 parts of euryale powder and 9 parts of liquorice powder.

[0041] Comparative Example 8 An immunity regulating granule containing composite plant powder comprises, by weight, 18 parts of kudzu root powder, 10 parts of polygonatum powder, 12 parts of euryale powder and 9 parts of liquorice powder.

[0042] Experimental Example 1: Immunity Test (1) Experimental animals: nude mice, half male and half female, weighing 18-22 g.

[0043] (2) Experimental Grouping: The mice were divided into 9 groups, each with 10 mice (half male and half female), and were fed with physiological saline (control group), immunity regulating granules of Examples 1-3, and Comparative Examples 1-8, respectively.

[0044] (3) Feeding method: The immune regulating granules were adjusted with water to a concentration equivalent to 0.6 g / ml. Mice were gavaged with physiological saline or test solution at a concentration of 0.5 ml / 20 g body weight once a day for 2 consecutive weeks.

[0045] (4) Test items and test indicators: The mouse peritoneal macrophage phagocytosis of chicken red blood cells was used to test the phagocytic index of mouse immune organs; the mouse dinitrofluorobenzene-induced DTH ear swelling test was used to test the thickening of the ear shell. The test results are shown in Table 1.

[0046] Table 1: Results of mouse immunity test

[0047] Note: Indicates P < 0.05 compared with the control group.

[0048] According to the data in Table 1, in the experiment of phagocytosis of chicken red blood cells by mouse peritoneal macrophages, the phagocytic percentage and phagocytic index of the immunomodulatory granules prepared in Examples 1-3 are significantly different from those of the control group, indicating that the immunomodulatory granules prepared in the present invention can improve the phagocytic index of immune organs and improve the function of mononuclear macrophages. In the DTH test induced by dinitrofluorobenzene, the weight gain of the ear shell of the immunomodulatory granules prepared in Examples 1-3 is higher than that of the control group, and the difference is statistically significant (P<0.05), indicating that the immunomodulatory granules prepared in Examples 1-3 can significantly improve the proliferation capacity of lymphocytes and improve cellular immune function. In contrast, although other combinations of medicinal and edible materials with immunomodulatory efficacy also have the effect of enhancing immune function, the effect is significantly lower than that of the combination of Examples 1-3, which indicates that the specific combination of the present invention achieves a better technical effect of immunomodulatory. From the results of Comparative Examples 6-8, it can be seen that when one of kelp and patchouli is not present, the immune-enhancing effect of the immunity-regulating granules is greatly weakened. Combining the results of Comparative Examples 1 and 4-5, it can be seen that when one of them is replaced by other medicinal and edible materials with immunity-regulating effects, the immune-enhancing effect of the immunity-regulating granules is increased, but still not as good as that in the embodiment, indicating that kelp and patchouli can synergistically enhance their effects.

[0049] Experimental Example 2 (1) Subjects: 60 immunocompromised patients aged 21 to 70 years.

[0050] (2) Grouping: The subjects were divided into 3 groups. Group 1 took the immunity regulating granules of Example 1 of the present invention, 10 g each time with water, twice a day; Group 2 took the immunity regulating granules of Comparative Example 5 of the present invention, 10 g each time with water, twice a day; Group 3 took commercially available ordinary protein powder for 2 consecutive months.

[0051] (3) Evaluation indicators: Significant effects: immunity is significantly improved, physical fitness is significantly enhanced, limbs are strong, energy is abundant, complexion is significantly improved, symptoms such as spots and dull skin disappear or are significantly improved, and sub-health conditions such as sleep and digestion are significantly improved; Effective: The immunity is improved, the physical fitness is strengthened, the limbs are stronger, the energy and complexion are improved, the symptoms such as spots and dull skin are improved, and the sub-healthy state in sleep and digestion is also improved; Ineffective: No improvement was observed in symptoms and examinations.

[0052] (4) Results: See Table 2.

[0053] Table 2: Results of the immunity evaluation of the subjects

[0054] According to the data in Table 1, compared with the immunity regulating granules prepared in Comparative Example 5 and ordinary protein powder, the immunity regulating granules prepared in Example 1 of the present invention can significantly and better improve the immunity of immunocompromised patients.

[0055] It should be noted that the preferred embodiments of the present invention are given in the specification of the present invention, but the present invention can be implemented in many different forms and is not limited to the embodiments described in this specification. These embodiments are not intended to be additional limitations on the content of the present invention. The purpose of providing these embodiments is to make the understanding of the disclosure of the present invention more thorough and comprehensive. In addition, the above-mentioned technical features continue to be combined with each other to form various embodiments not listed above, which are all considered to be within the scope of the present invention specification; further, for ordinary technicians in this field, they can be improved or transformed according to the above description, and all these improvements and transformations should belong to the protection scope of the claims attached to the present invention.

Claims

1. An immunity regulating granule containing a composite plant powder, characterized in that: The composite plant powder comprises kudzu root powder, polygonatum sibiricum powder, kelp powder, patches of osmanthus powder, euryale powder and liquorice powder.

2. The immunity regulating granules according to claim 1, characterized in that: The composite plant powder comprises 17-23 parts of kudzu root powder, 6-12 parts of polygonatum powder, 15-20 parts of kelp powder, 12-18 parts of patchouli powder, 10-15 parts of euryale powder and 8-13 parts of liquorice powder by weight.

3. The immunity regulating granules according to claim 1, characterized in that: The composite plant powder comprises 18 parts of kudzu root powder, 10 parts of polygonatum powder, 16 parts of kelp powder, 15 parts of patchouli powder, 12 parts of euryale powder and 9 parts of liquorice powder by weight.

4. The immunity regulating granules according to claim 1, characterized in that: The composite plant powder further comprises one or more of oatmeal powder, black bean powder, pea powder, black rice powder and tartary buckwheat powder.

5. The immunity regulating granules according to claim 4, characterized in that: The composite plant powder further comprises, by weight, 0-10 parts of oatmeal powder, 0-15 parts of black bean powder, 0-10 parts of pea powder, 0-20 parts of black rice powder and 0-15 parts of tartary buckwheat powder.

6. The immunity regulating granules according to claim 4, characterized in that: The composite plant powder further comprises 8 parts of oatmeal powder, 13 parts of black bean powder, 5 parts of pea powder, 18 parts of black rice powder and 11 parts of tartary buckwheat powder by weight.

7. A method for preparing the immunity regulating granules as claimed in claim 1, characterized in that: The following steps are involved: Pueraria root, polygonatum sibiricum, kelp, patchouli, euryale ferox and liquorice are selected respectively, washed, dried, crushed and sieved, and then ingredients are added according to required weight portions and mixed to obtain immunity regulating granules.

8. The preparation method according to claim 7, characterized in that: The weight proportions used in the mixing of ingredients are 17-23 parts of kudzu root powder, 6-12 parts of polygonatum powder, 15-20 parts of kelp powder, 12-18 parts of patchouli powder, 10-15 parts of euryale powder and 8-13 parts of liquorice powder.

9. The preparation method according to claim 7 or 8, characterized in that: The method also includes selecting one or more of oats, black beans, peas, black rice and bitter buckwheat as additional raw materials.

10. The preparation method according to claim 9, characterized in that: When preparing the ingredients, the additional raw materials are used in the following weight proportions: 0-10 parts of oat flour, 0-15 parts of black bean flour, 0-10 parts of pea flour, 0-20 parts of black rice flour and 0-15 parts of tartary buckwheat flour.

Images