Oral liquid for dispelling effects of alcohol and resisting drunkenness and preparation method

Abstract

The invention discloses a hangover-alleviating anti-drunkenness oral liquid and a preparation method thereof. The hangover-alleviating anti-drunkenness oral liquid is mainly prepared from the following components in parts by weight: 5-60 parts of acetaldehyde dehydrogenase microcapsule powder, 0-10 parts of vitamin E microcapsule powder, 0-60 parts of glutathione, 1030 parts of vitamin C, 1-10 parts of milk thistle extract and 1-10 parts of dihydromyricetin. Through the synergistic effect of compatibility of the components, rapid and effective decomposition of ethanol is promoted through multiple ways, and toxic substances and free radicals are removed. According to the preparation method and application of the hangover-alleviating hangover-alleviating hangover-alleviating product, the hangover-alleviating hangover-alleviating hangover-alleviating hangover-alleviating hangover-alleviating hangover-alleviating hangover-alleviating hangover-alleviating hangover-alleviating hangover-alleviating hangover-alleviating hangover-alleviating hangover-alleviating hangover-alleviating hangover-alleviating hangover-alleviating hangover-alleviating hangover-alleviating hangover-alleviating hangover-alleviating hangover- The beverage is high in absorption and utilization rate of a human body, especially has no obvious peculiar smell of plant extracts in mouth feel, is not obviously sour or sweet, and greatly improves the mouth feel comfort when a consumer drinks the beverage.

Description

Technical Field

[0001] The invention relates to the technical field of biopharmaceuticals, and in particular to an oral liquid for sobering up and resisting intoxication and a preparation method thereof. Background Art

[0002] Wine is a mixed drink containing multiple ingredients, the most important of which is ethanol (i.e. alcohol), which is the main factor causing drunkenness. The absorption and metabolism mechanism of ethanol is as follows: ethanol enters the human blood circulation through the absorption of the stomach and intestines, and then undergoes metabolic decomposition of ethanol. The reason why people get drunk is determined by the content of acetaldehyde in the human body: because the human body can only metabolize a certain amount of ethanol under normal circumstances, when drinking too much, the amount of ethanol oxidized into acetaldehyde increases, and the human body's decomposition of acetaldehyde is limited within a certain period of time. When the acetaldehyde content is too high, the human body cannot decompose it in time, and acetaldehyde enters the blood and is absorbed, causing serious damage to the body's important organs and functions. Excitement of the mind, dizziness, vomiting and various discomforts occur, which is the so-called "drunkenness".

[0003] However, existing alcohol sobering and anti-intoxication products have some problems in practical application. First, the pure acetaldehyde dehydrogenase (ALDH) has poor stability in the body and is easily decomposed in the stomach, which affects its bioavailability and leads to poor alcohol sobering effect. Secondly, the pure ALDH usually has a bad taste and flavor, which will affect the acceptance of the product. In addition, the existing preparation process is relatively complicated, and the feasibility of industrial production is low, which also limits the promotion and application of such products to a certain extent. Summary of the invention

[0004] In view of the deficiencies in the prior art, the present invention provides an oral liquid for sobering up and resisting intoxication and a preparation method thereof. The oral liquid for sobering up and resisting intoxication has good sobering up and liver protecting effects, high absorption and utilization rate by the human body, and a pleasant taste without bad smell.

[0005] The present invention is achieved through the following technical solutions:

[0006] The invention discloses an oral liquid for sobering up and resisting drunkenness, which is prepared from the following raw materials in parts by weight: 5-60 parts of acetaldehyde dehydrogenase microcapsule powder, 0-10 parts of vitamin E microcapsule powder, 0-60 parts of glutathione, 10-30 parts of vitamin C, 1-10 parts of milk thistle extract and 1-10 parts of dihydromyricetin.

[0007] Furthermore, it is mainly made of the following raw materials in parts by weight: 15-45 parts of acetaldehyde dehydrogenase microcapsule powder, 2-9 parts of vitamin E microcapsule powder, 15-45 parts of glutathione, 12-20 parts of vitamin C, 2-4 parts of milk thistle extract, and 2-4 parts of dihydromyricetin.

[0008] Furthermore, the following raw materials are included in parts by weight: 0.01-0.2 parts of sweetener, 1-10 parts of flavoring agent, and 0.1-1 parts of flavor.

[0009] Furthermore, the sweetener is one of sucralose, steviol glycosides, acesulfame potassium, and mogroside.

[0010] Furthermore, the flavoring agent is one of citric acid and DL-malic acid.

[0011] Furthermore, the flavor is one or two or more of orange oil, lemon oil, sweet orange flavor, lemon flavor, and black tea flavor.

[0012] Furthermore, the preparation method of the acetaldehyde dehydrogenase microcapsule powder is as follows: the pure acetaldehyde dehydrogenase is dissolved in an aqueous solution, then added to a mixed solution of chitosan and gum arabic, stirred evenly, then added to a cross-linking solution containing glutaraldehyde, stirred evenly again, and allowed to stand for a period of time to microencapsulate ALDH.

[0013] Furthermore, the concentration of the pure acetaldehyde dehydrogenase is 0.5-1.5 mg / mL, the concentration of the mixed solution of chitosan and gum arabic is 1.0-1.2% (w / v), and the concentration of the cross-linking solution of glutaraldehyde is 0.5-0.8% (v / v).

[0014] A method for preparing an oral liquid for sobering up and resisting drunkenness comprises the following steps:

[0015] S1. Weigh 5-60 parts of acetaldehyde dehydrogenase microcapsule powder, 0-10 parts of vitamin E microcapsule powder, 0-60 parts of glutathione, 10-30 parts of vitamin C, 1-10 parts of milk thistle extract, 1-10 parts of dihydromyricetin, 0.01-0.2 parts of sweetener, 1-10 parts of flavoring agent, and 0.1-1 parts of essence.

[0016] S2. Evenly mix the weighed acetaldehyde dehydrogenase microcapsule powder, vitamin E microcapsule powder, glutathione, vitamin C, milk thistle extract and dihydromyricetin, and add them into the mixed liquid containing flavors, sweeteners and flavor correctants. Stir evenly in a hot water bath at 10-60 rpm for 5-15 minutes to obtain the hangover-relieving and anti-drunkenness oral liquid.

[0017] Furthermore, the concentration of the mixed liquid containing flavors, sweeteners and flavoring agents is 1.0-1.5% (v / v).

[0018] Compared with the prior art, the advantages of the present invention are:

[0019] 1. By microencapsulating pure acetaldehyde dehydrogenase, the stability and bioavailability of acetaldehyde dehydrogenase in the body can be effectively improved. After the user drinks the oral solution, the outer membrane of the microcapsule is not easily decomposed by gastric enzymes and gastric acid, and it slowly decomposes after entering the small intestine, so that acetaldehyde dehydrogenase enters the liver with body fluid circulation, plays the role of alcohol detoxification enzyme, effectively improves the human body absorption rate of acetaldehyde dehydrogenase, and improves the alcohol detoxification effect.

[0020] 2. Prepare a product for sobering up and protecting the liver, the raw material components of which include: 5-60 parts of acetaldehyde dehydrogenase microcapsule powder, 0-10 parts of vitamin E microcapsule powder, 0-60 parts of glutathione, 10-30 parts of vitamin C, 1-10 parts of milk thistle extract, 1-10 parts of dihydromyricetin, 0.01-0.2 parts of sweeteners, 1-10 parts of flavoring agents, and 0.1-1 parts of flavors. The combination of these raw materials can effectively improve the sobering up effect of the product, improve the taste and flavor of the product, and improve consumer acceptance. This will help promote the development and application of sobering up and anti-intoxication foods, and meet the market demand for efficient, safe, and good-tasting sobering up and anti-intoxication foods. In general, the technical application prospects of the present invention are broad, the market demand is large, and it is expected to play an important role in the fields of pharmaceutical chemistry, biotechnology, and food science.

[0021] 3. The weighed acetaldehyde dehydrogenase microcapsule powder, vitamin E microcapsule powder, glutathione, vitamin C, milk thistle extract, and dihydromyricetin are mixed evenly and added to the mixed liquid containing flavors, sweeteners, and flavor correctors, and stirred evenly in a hot water bath at 10-60 rpm for 5-15 minutes to obtain an oral liquid for alcohol detoxification and anti-intoxication. The problem that the existing preparation process is relatively complicated and the feasibility of industrial production is low is solved. By simplifying the preparation process, industrial production is highly feasible, economical, and environmentally friendly. DETAILED DESCRIPTION

[0022] In order to make the purpose, technical scheme and advantages of the present invention clearer, the present invention is further described in detail below in conjunction with the embodiments, so that those skilled in the art can fully understand the technical content of the present invention. It should be understood that the following examples are used to further illustrate the present invention and cannot be interpreted as limiting the scope of protection of the present invention. Some non-essential improvements and adjustments made by those skilled in the art according to the above content of the present invention belong to the scope of protection of the present invention. The following examples of specific preparation method parameters are also only an example in a suitable range, that is, those skilled in the art can make a selection within a suitable range according to the description herein, and are not limited to the specific numerical values ​​​​exemplified below.

[0023] An oral liquid for sobering up and resisting drunkenness according to an embodiment of the present invention is prepared from the following raw materials in parts by weight: 5-60 parts of acetaldehyde dehydrogenase microcapsule powder, 0-10 parts of vitamin E microcapsule powder, 0-60 parts of glutathione, 10-30 parts of vitamin C, 1-10 parts of milk thistle extract, 1-10 parts of dihydromyricetin, 0.01-0.2 parts of sweetener, 1-10 parts of flavoring agent, and 0.1-1 parts of essence.

[0024] Preferably, an oral liquid for sobering up and resisting drunkenness is mainly made of the following raw materials in parts by weight: 15-45 parts of acetaldehyde dehydrogenase microcapsule powder, 2-9 parts of vitamin E microcapsule powder, 15-45 parts of glutathione, 12-20 parts of vitamin C, 2-4 parts of milk thistle extract, 2-4 parts of dihydromyricetin, 0.01-0.2 parts of sweetener, 1-10 parts of flavoring agent, and 0.1-1 parts of flavor.

[0025] The sweetener is one of sucralose, steviol glycoside, acesulfame potassium and mogroside.

[0026] The flavoring agent is one of citric acid and DL-malic acid.

[0027] The flavor is one or two or more of oil-soluble flavors such as orange oil and lemon oil and water-soluble flavors such as sweet orange flavor, lemon flavor, and black tea flavor. The preferred flavors are lemon oil and lemon flavor, which can effectively improve the taste and flavor of the product.

[0028] Acetaldehyde dehydrogenase and vitamin E can wrap the active ingredients in the form of microcapsules, reducing the decomposition of effective ingredients by gastric acid, gastric enzymes and other substances. After the user drinks the oral liquid, the outer membrane of the microcapsule is not easily decomposed by gastric enzymes and gastric acid, and it slowly decomposes after entering the small intestine, so that acetaldehyde dehydrogenase enters the liver with the body fluid circulation, plays the role of alcohol-degrading enzyme, effectively improves the human body's absorption rate of acetaldehyde dehydrogenase, and improves the alcohol-degrading effect.

[0029] The mechanism of action of the above combination is as follows:

[0030] Vitamin E. Both human and animal studies have shown that vitamin E (α-tocopherol) is the most effective antioxidant in nature. Vitamin E deficiency can reduce the body's ability to resist lipid peroxidation, which is closely related to the occurrence and development of NASH (non-alcoholic fatty liver disease). Clinical studies have shown that vitamin E can improve serum transaminases and liver histological parameters in patients with NAFLD (non-alcoholic fatty liver disease) (including NASH). Animal experiments have also shown that vitamin E can reverse liver fatty degeneration and damage by inhibiting lipid peroxidation.

[0031] Glutathione, a tripeptide containing sulfhydryl groups and composed of glutamic acid, cysteine ​​and glycine, has antioxidant and integrated detoxification effects. Glutathione has a broad-spectrum detoxification effect and can be used not only in medicines but also as a base material for functional foods. Due to the detoxification and antioxidant capabilities of glutathione itself, glutathione has an important role in protecting the liver.

[0032] Vitamin C is an important antioxidant in the human body and an effective scavenger of free radicals. It can effectively reduce the damage caused by alcohol metabolism to the body. Vitamin C can convert oxidized glutathione into reduced glutathione (GSH) to reduce hydrogen peroxide produced by body metabolism. Therefore, when the present invention selects vitamin C, it is used together with glutathione to improve its efficacy. In addition, vitamin C can synergize with the flavonoids in the leaves of the Agave striata in the formula, thereby achieving the effects of acute alcohol sobering and preventing drunkenness, and chronic liver protection.

[0033] Milk thistle extract. The silymarin contained in milk thistle extract can enhance the liver's detoxification function and protect liver cells from damage. In addition, milk thistle also has an antioxidant effect, which can help the liver remove free radicals, increase the level of glutathione in the liver, and play a role in protecting the liver. At the same time, milk thistle contains a variety of nutrients that can nourish liver cells, promote blood circulation in the liver, increase the metabolic capacity of liver cells, and enhance the liver's detoxification ability.

[0034] Dihydromyricetin can inhibit the formation of fatty liver, reduce the degeneration and necrosis of liver tissue, thereby achieving the effect of lowering enzymes and jaundice, and has obvious liver-protecting effects.

[0035] In this embodiment, the preparation method of ALDH microcapsule powder is as follows: pure ALDH is dissolved in an aqueous solution, then added to a mixed solution of chitosan and gum arabic, stirred evenly, then added to a cross-linking solution containing glutaraldehyde, stirred evenly again, and allowed to stand for a period of time to microencapsulate ALDH. The concentration of pure ALDH is 0.5-1.5 mg / mL, the concentration of the mixed solution of chitosan and gum arabic is 1.0-1.2% (w / v), and the concentration of the cross-linking solution of glutaraldehyde is 0.5-0.8% (v / v).

[0036] A method for preparing an oral liquid for sobering up and resisting drunkenness comprises the following steps:

[0037] S1. Weigh 5-60 parts of acetaldehyde dehydrogenase microcapsule powder, 0-10 parts of vitamin E microcapsule powder, 0-60 parts of glutathione, 10-30 parts of vitamin C, 1-10 parts of milk thistle extract, 1-10 parts of dihydromyricetin, 0.01-0.2 parts of sweetener, 1-10 parts of flavoring agent, and 0.1-1 parts of essence.

[0038] S2. Evenly mix the weighed acetaldehyde dehydrogenase microcapsule powder, vitamin E microcapsule powder, glutathione, vitamin C, milk thistle extract and dihydromyricetin, and add them into the mixed liquid containing flavors, sweeteners and flavor correctants. Stir evenly in a hot water bath at 10-60 rpm for 5-15 minutes to obtain the hangover-relieving and anti-drunkenness oral liquid.

[0039] The concentration of the mixed liquid containing essence, sweetener and flavor corrector is 1.0-1.5% (v / v).

[0040] How to use and dosage: Can be taken before or after drinking alcohol, 60ml each time.

[0041] The following is combined with specific embodiments to further illustrate and describe the concept of the present invention, but it does not mean that the present invention is limited to the specific scheme described below. In the embodiments, any specific numerical value within the scope of the present invention is applicable.

[0042] Embodiment 1:

[0043] S1. Weigh 25 parts of acetaldehyde dehydrogenase microcapsule powder, 6 parts of vitamin E microcapsule powder, 25 parts of glutathione, 10 parts of vitamin C, 2 parts of milk thistle extract, 2 parts of dihydromyricetin, 0.02 parts of sucralose, 3 parts of citric acid, and 0.5 parts of lemon oil.

[0044] S2, the weighed acetaldehyde dehydrogenase microcapsule powder, vitamin E microcapsule powder, glutathione, vitamin C, milk thistle extract, dihydromyricetin are mixed evenly and added to the mixed liquid containing flavors, sweeteners and flavoring agents, stirred evenly in a hot water bath at 40 rpm, and kept for 5 minutes to obtain an oral liquid for alcohol detoxification and anti-intoxication. The concentration of the mixed liquid containing flavors, sweeteners and flavoring agents is 1.0% (v / v).

[0045] The hangover and anti-drunkenness oral solution is a dark yellow uniform liquid with a pleasant smell.

[0046] Embodiment 2:

[0047] S1. Weigh 15 parts of acetaldehyde dehydrogenase microcapsule powder, 5 parts of vitamin E microcapsule powder, 35 parts of glutathione, 12 parts of vitamin C, 4 parts of milk thistle extract, 4 parts of dihydromyricetin, 0.02 parts of sucralose, 3 parts of citric acid, and 0.8 parts of lemon oil.

[0048] S2, the weighed acetaldehyde dehydrogenase microcapsule powder, vitamin E microcapsule powder, glutathione, vitamin C, milk thistle extract, dihydromyricetin are mixed evenly and added to the mixed liquid containing flavors, sweeteners and flavoring agents, stirred evenly in a hot water bath at 40 rpm, and kept for 5 minutes to obtain an oral liquid for alcohol detoxification and anti-intoxication. The concentration of the mixed liquid containing flavors, sweeteners and flavoring agents is 1.0% (v / v).

[0049] The hangover and anti-drunkenness oral solution is a dark yellow uniform liquid with a pleasant smell.

[0050] Embodiment three:

[0051] S1. Weigh 45 parts of acetaldehyde dehydrogenase microcapsule powder, 3 parts of vitamin E microcapsule powder, 15 parts of glutathione, 10 parts of vitamin C, 2 parts of milk thistle extract, 2 parts of dihydromyricetin, 0.02 parts of sucralose, 3 parts of citric acid, and 0.5 parts of lemon oil.

[0052] S2, the weighed acetaldehyde dehydrogenase microcapsule powder, vitamin E microcapsule powder, glutathione, vitamin C, milk thistle extract, dihydromyricetin are mixed evenly and added to the mixed liquid containing flavors, sweeteners and flavoring agents, stirred evenly in a hot water bath at 40 rpm, and kept for 5 minutes to obtain an oral liquid for alcohol detoxification and anti-intoxication. The concentration of the mixed liquid containing flavors, sweeteners and flavoring agents is 1.0% (v / v).

[0053] The hangover and anti-drunkenness oral solution is a dark yellow uniform liquid with a pleasant smell.

[0054] Embodiment 4:

[0055] S1. Weigh 35 parts of acetaldehyde dehydrogenase microcapsule powder, 2 parts of vitamin E microcapsule powder, 15 parts of glutathione, 10 parts of vitamin C, 2 parts of milk thistle extract, 2 parts of dihydromyricetin, 0.02 parts of sucralose, 3 parts of citric acid, and 0.4 parts of lemon oil.

[0056] S2, the weighed acetaldehyde dehydrogenase microcapsule powder, vitamin E microcapsule powder, glutathione, vitamin C, milk thistle extract, dihydromyricetin are mixed evenly and added to the mixed liquid containing flavors, sweeteners and flavoring agents, stirred evenly in a hot water bath at 40 rpm, and kept for 5 minutes to obtain an oral liquid for alcohol detoxification and anti-intoxication. The concentration of the mixed liquid containing flavors, sweeteners and flavoring agents is 1.0% (v / v).

[0057] The hangover and anti-drunkenness oral solution is a dark yellow uniform liquid with a pleasant smell.

[0058] Embodiment five:

[0059] S1. Weigh 25 parts of acetaldehyde dehydrogenase microcapsule powder, 10 parts of vitamin E microcapsule powder, 45 parts of glutathione, 12 parts of vitamin C, 2 parts of milk thistle extract, 2 parts of dihydromyricetin, 0.02 parts of sucralose, 3 parts of citric acid, and 0.5 parts of lemon oil.

[0060] S2, the weighed acetaldehyde dehydrogenase microcapsule powder, vitamin E microcapsule powder, glutathione, vitamin C, milk thistle extract, dihydromyricetin are mixed evenly and added to the mixed liquid containing flavors, sweeteners and flavoring agents, stirred evenly in a hot water bath at 40 rpm, and kept for 5 minutes to obtain an oral liquid for alcohol detoxification and anti-intoxication. The concentration of the mixed liquid containing flavors, sweeteners and flavoring agents is 1.0% (v / v).

[0061] The hangover and anti-drunkenness oral solution is a dark yellow uniform liquid with a pleasant smell.

[0062] Embodiment six:

[0063] S1. Weigh 35 parts of acetaldehyde dehydrogenase microcapsule powder, 9 parts of vitamin E microcapsule powder, 15 parts of glutathione, 14 parts of vitamin C, 2 parts of milk thistle extract, 2 parts of dihydromyricetin, 0.02 parts of sucralose, 3 parts of citric acid, and 0.2 parts of lemon oil.

[0064] S2, the weighed acetaldehyde dehydrogenase microcapsule powder, vitamin E microcapsule powder, glutathione, vitamin C, milk thistle extract, dihydromyricetin are mixed evenly and added to the mixed liquid containing flavors, sweeteners and flavoring agents, stirred evenly in a hot water bath at 40 rpm, and kept for 5 minutes to obtain an oral liquid for alcohol detoxification and anti-intoxication. The concentration of the mixed liquid containing flavors, sweeteners and flavoring agents is 1.0% (v / v).

[0065] The hangover and anti-drunkenness oral solution is a dark yellow uniform liquid with a pleasant smell.

[0066] Alcohol dehydrogenase (ADH) is the main enzyme that breaks down alcohol in the human body. It is mainly distributed in the liver and gastrointestinal tract. The speed at which it breaks down alcohol is much slower than the absorption rate of alcohol. The speed at which ADH breaks down alcohol is mainly related to the amount of ADH. After alcohol enters the human body, most of the alcohol is mainly oxidized to acetaldehyde by ADH, and a small amount of unmetabolized alcohol is excreted from the body through breathing and urine. Alcohol is first absorbed in the gastrointestinal tract, at which time gastrointestinal ADH breaks down alcohol (first-pass effect); secondly, in the body, ADH in the liver catalyzes the alcohol absorbed into the blood into acetaldehyde, and a small amount is converted into acetaldehyde through the microsomal ethanol oxidation system. Acetaldehyde is converted into acetic acid by ALDH, and then through the tricarboxylic acid cycle, and finally generates CO2 and H2O and is excreted from the body. Therefore, ADH plays an important role in alcohol metabolism. The metabolic rate of alcohol mainly depends on the activity of the metabolic enzyme system in the liver. By observing the content of liver ADH and the changes in blood alcohol concentration, the effects of alcohol-detoxifying and liver-protecting functional beverages on alcohol metabolism can be examined.

[0067] It should be pointed out that the above preferred embodiments are only for illustrating the technical concept and features of the present invention, and their purpose is to enable people familiar with the technology to understand the content of the present invention and implement it accordingly, and they cannot be used to limit the protection scope of the present invention. Any equivalent changes or modifications made according to the spirit of the present invention should be included in the protection scope of the present invention.

Claims

1. An oral liquid for sobering up and resisting drunkenness, characterized in that: The invention is prepared from the following raw materials in parts by weight: 5-60 parts of acetaldehyde dehydrogenase microcapsule powder, 0-10 parts of vitamin E microcapsule powder, 0-60 parts of glutathione, 10-30 parts of vitamin C, 1-10 parts of milk thistle extract and 1-10 parts of dihydromyricetin.

2. The oral liquid for sobering up and resisting drunkenness according to claim 1, characterized in that: The invention is mainly prepared from the following raw materials in parts by weight: 15-45 parts of acetaldehyde dehydrogenase microcapsule powder, 2-9 parts of vitamin E microcapsule powder, 15-45 parts of glutathione, 12-20 parts of vitamin C, 2-4 parts of milk thistle extract and 2-4 parts of dihydromyricetin.

3. The oral liquid for sobering up and resisting drunkenness according to claim 1, characterized in that: The invention also comprises the following raw materials in parts by weight: 0.01-0.2 parts of sweetener, 1-10 parts of flavoring agent and 0.1-1 parts of essence.

4. The oral liquid for sobering up and resisting drunkenness according to claim 3, characterized in that: The sweetener is one of sucralose, steviol glycoside, acesulfame potassium and mogroside.

5. The oral liquid for sobering up and resisting drunkenness according to claim 3, characterized in that: The flavoring agent is one of citric acid and DL-malic acid.

6. The oral liquid for sobering up and resisting drunkenness according to claim 3, characterized in that: The flavor is one or two or more of orange oil, lemon oil, sweet orange flavor, lemon flavor, and black tea flavor.

7. The oral liquid for sobering up and resisting drunkenness according to claim 1, characterized in that: The preparation method of the acetaldehyde dehydrogenase microcapsule powder is as follows: dissolving the pure acetaldehyde dehydrogenase in an aqueous solution, then adding it to a mixed solution of chitosan and gum arabic, stirring evenly, then adding it to a cross-linking solution containing glutaraldehyde, stirring evenly again, and standing for a period of time to microencapsulate ALDH.

8. The oral liquid for sobering up and resisting drunkenness according to claim 7, characterized in that: The concentration of the pure acetaldehyde dehydrogenase is 0.5-1.5 mg / mL, the concentration of the mixed solution of chitosan and gum arabic is 1.0-1.2% (w / v), and the concentration of the cross-linking solution of glutaraldehyde is 0.5-0.8% (v / v).

9. A method for preparing an oral liquid for sobering up and resisting drunkenness, characterized in that: The steps include: S1. Weigh 5-60 parts of acetaldehyde dehydrogenase microcapsule powder, 0-10 parts of vitamin E microcapsule powder, 0-60 parts of glutathione, 10-30 parts of vitamin C, 1-10 parts of milk thistle extract, 1-10 parts of dihydromyricetin, 0.01-0.2 parts of sweetener, 1-10 parts of flavoring agent, and 0.1-1 parts of essence; S2. Evenly mix the weighed acetaldehyde dehydrogenase microcapsule powder, vitamin E microcapsule powder, glutathione, vitamin C, milk thistle extract and dihydromyricetin, and add them into the mixed liquid containing flavors, sweeteners and flavor correctants. Stir evenly in a hot water bath at 10-60 rpm for 5-15 minutes to obtain the hangover-relieving and anti-drunkenness oral liquid.

10. The method for preparing the oral liquid for sobering up and resisting drunkenness according to claim 9, characterized in that: The concentration of the mixed liquid containing essence, sweetener and flavoring agent is 1.0-1.5% (v / v).