Biological electromagnetic stimulation system based on extremely low frequency magnetic field

Abstract

The invention belongs to the technical field of biomedical engineering, and particularly relates to a biological electromagnetic stimulation system based on an extremely-low-frequency magnetic field. The system comprises a control host, an integrated stimulation coil and an air cooling system, the integrated stimulation coil is composed of two Helmholtz coils which are arranged in parallel and is used for generating a uniform magnetic field; the air cooling system is integrated in the Helmholtz coil and is used for reducing the working temperature of the coil; the control host comprises an operation panel, a single-chip microcomputer circuit, a power supply circuit, a sine wave control circuit, a pulse control circuit and an upper computer serial interface. The operation panel is provided with a mode selection button, an intensity adjustment button and a timing setting button. The single-chip microcomputer circuit is responsible for controlling the whole system, the sine wave control circuit is used for outputting sine wave waveforms, and the pulse control circuit is used for outputting pulse waveforms. An alternating magnetic field noninvasively penetrates through the brain barrier, induced current is generated in intracranial tissue and directly acts on a focus area, and the purposes of improving blood circulation, repairing the neurological function and adjusting brain magnetic balance are achieved.

Description

Technical Field

[0001] The present invention relates to the field of biomedical engineering technology, and specifically to a bio-electromagnetic system based on an extremely low frequency magnetic field (ELF-MF), which improves brain blood circulation and nerve function through non-invasive electromagnetic field stimulation technology, and is suitable for treatment scenarios such as cerebrovascular diseases and brain injury repair. Background Art

[0002] Traditional treatments for brain diseases mainly rely on drugs or surgery. Although these methods are effective, they are often accompanied by significant side effects and high trauma. In recent years, transcranial magnetic stimulation (TMS) technology has attracted widespread attention due to its non-invasive characteristics. However, existing TMS systems generally have problems such as insufficient magnetic field uniformity, a single treatment mode, and low temperature control efficiency. They usually only support a single waveform output, which makes it difficult to meet the personalized needs of different treatment scenarios.

[0003] In response to the above problems, this application proposes a bioelectromagnetic stimulation system based on an extremely low frequency magnetic field. Unlike traditional physical therapy, ELF-MF technology does not need to rely on large auxiliary equipment or complex imaging technology for accurate brain topography guidance and positioning, thus providing higher cost performance and flexibility. The system integrates a bioelectromagnetic stimulation device with sine wave and pulse dual modes and is equipped with an efficient air cooling system. By optimizing the coil design and control circuit, it achieves a significant improvement in the uniformity of the magnetic field, flexible switching of multiple modes, and precise control of temperature. These improvements not only significantly improve the treatment effect, but also greatly enhance the safety of the treatment process. Through this innovative design, a more efficient, safe and flexible new method for the treatment of brain diseases is provided. Summary of the invention

[0004] In view of the deficiencies in the prior art, the technical problem to be solved by the present invention is to provide a bio-electromagnetic stimulation system based on an extremely low frequency magnetic field.

[0005] The present invention solves the technical problem by adopting the following technical solution:

[0006] A bioelectromagnetic stimulation system based on an extremely low frequency magnetic field is characterized in that it includes a control host, an integrated stimulation coil and an air cooling system; the integrated stimulation coil is composed of two parallel Helmholtz coils and is used to generate a uniform magnetic field; the air cooling system is integrated inside the Helmholtz coil and is used to reduce the working temperature of the coil; the control host includes an operation panel, a single-chip microcomputer circuit, a power supply circuit, a sine wave control circuit, a pulse control circuit and a host computer serial interface, and the operation panel has mode selection, intensity adjustment, and timing setting buttons; the single-chip microcomputer circuit is responsible for the control of the entire system, the sine wave control circuit is used to output a sine wave waveform, and the pulse control circuit is used to output a pulse waveform.

[0007] Furthermore, the power supply circuit includes a power input module, a rectification and filtering module, a voltage stabilization module, a control module, a drive module, and a protection and indication module; the power input module connects a 220V AC power supply and a DC power supply through a power input terminal and converts the 220V AC power into AC power through a transformer; the rectification and filtering module converts the AC power into DC power through a rectifier bridge, and filters the rectified DC power through a filter capacitor; the voltage stabilization module stabilizes the filtered DC power to 5V and 12V through a voltage stabilization IC; the control module is used to generate a pulse signal and change the pulse frequency by adjusting the resistor and capacitor; the drive module uses MOSFET as a switching element to control a large current load; the protection and indication module uses a fuse and a varistor to provide overcurrent and overvoltage protection.

[0008] Furthermore, the system includes two stimulation modes: a sine wave mode and a pulse mode; the sine wave mode includes multiple preset modes, and the preset mode is adjusted by changing the period, magnetic field strength and duty cycle; the pulse mode includes multiple preset modes, and different waveforms are output by changing the frequency and magnetic field strength.

[0009] Furthermore, by outputting a low-frequency magnetic field of 2s-16s in sinusoidal wave mode, it can promote cerebral vasodilation, improve brain blood circulation, increase brain blood flow, and improve brain cell metabolism.

[0010] Furthermore, by outputting a 10-50Hz pulse signal through the pulse mode, it can activate nerve conduction, quickly repair damaged brain cells, and promote the recovery of nerve function.

[0011] Furthermore, through the combined use of the sine wave mode and the pulse mode, it can improve the blood circulation in the lesion area, reduce the hardening of the cerebral blood vessel wall, and enhance the self-repair ability of damaged cells.

[0012] Furthermore, the air cooling system includes an air cooling fan.

[0013] Compared with the prior art, the present invention has the following beneficial effects:

[0014] The present invention is based on Faraday's law of electromagnetic induction. It uses an alternating magnetic field to non-invasively penetrate the cranial-brain barrier, generate induced currents in intracranial tissues, and directly act on the lesion area to achieve the following effects: 1. Improve blood circulation: increase the elasticity of cerebral blood vessels, improve blood flow and oxygen supply capacity. 2. Repair nerve function: activate the neuroprotective mechanism, promote the metabolism and self-repair of damaged cells. 3. Regulate brain magnetic balance: guide the normalization of brain magnetic function and relieve symptoms of brain injury.

[0015] Improved magnetic field uniformity: The Helmholtz coil design makes the magnetic field uniformity in the stimulation area reach ±2%, which is better than the traditional single coil. Diversified treatment modes: 18 preset modes cover the needs of different diseases, such as sine waves to promote vasodilation and pulses to activate nerve conduction. Enhanced safety: The interlocking mechanism and temperature control system reduce the equipment failure rate to less than 0.1%. Convenient operation: Supports dual control of the panel and the host computer, suitable for clinical and scientific research scenarios. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 The overall diagram of the present invention; 01, control host; 02, operation panel; 03, experimental box; 04, integrated stimulation coil; 05, air cooling system;

[0017] Figure 2 This is the control panel diagram of the present invention; the panel includes the following functional areas: mode selection module: 2 "mode" buttons (mode +, mode -, current mode display); intensity adjustment module: "intensity +" "intensity -" buttons and real-time intensity display (unit: mT). Timing setting module: "timing" button supports 30 / 45 / 60 minutes three-speed cycle switching; start-stop control module: independent sine wave and pulse mode "start-stop" buttons, equipped with status indicator lights;

[0018] Figure 3 This is the pulse mode output waveform of the present invention; 10 pulse modes are output with different frequencies (10-50Hz) and amplitude combinations, with a peak intensity of 10mT, which is suitable for rapid nerve activation scenarios;

[0019] Figure 4 This is the waveform diagram of the sine wave mode output of the present invention; it shows the parameters of 8 sine wave modes: output period: 2s (mode 01) to 16s (mode 08). Intensity adjustment: duty cycle 0-100% corresponds to magnetic field intensity 0-10mT; waveform characteristics: 50Hz base frequency superimposed modulation pulse, pulse width fixed at 20ms. DETAILED DESCRIPTION

[0020] Specific embodiments are given below in conjunction with the accompanying drawings. The specific embodiments are only used to introduce the technical solutions of the present invention in detail and are not intended to limit the protection scope of the present application.

[0021] The present invention provides a bioelectromagnetic stimulation system based on an extremely low frequency magnetic field, comprising a control host, an integrated stimulation coil, and an air cooling system. The control host is used to adjust the stimulation parameters, and comprises an operation panel: including mode selection, intensity adjustment, and timing setting buttons. Control circuit: single-chip circuit, sine wave control circuit, pulse control circuit, and host computer serial interface. DC power supply circuit: provides stable power supply. By selecting the required stimulation waveform and stimulation parameters on the operation panel, the integrated stimulation coil is acted on through the single-chip circuit, power supply circuit, sine wave control circuit, and pulse control circuit; the integrated stimulation coil outputs a corresponding uniform magnetic field in the stimulation area through the selected stimulation waveform and stimulation mode; since the stimulation coil generates heat during operation, in order to prevent the coil from overheating and support long-term operation, the air cooling system is turned on at the beginning of the stimulation, and the temperature is reduced by the integrated cooling fan, so as to provide a more suitable stimulation environment. The system has the characteristics of non-invasive portability, and can change the stimulation parameters in real time according to the pathological state and user needs, realize real-time stimulation, and achieve the best stimulation effect.

[0022] Specifically, the power supply circuit includes: power input module: two power input terminals, connected to the AC power supply (220VAC) and the DC power supply respectively, and the 220V AC power is converted into a lower AC voltage through a transformer. Rectification and filtering module: the rectifier bridge converts the AC power into DC power. The filter capacitor is used to smooth the rectified DC power. Voltage regulator module: the DC voltage is stabilized to 5V and 12V using a voltage regulator IC for use in subsequent circuits. The voltage regulator circuit contains feedback resistors and filter capacitors. Control module: a 555 timer is used to generate a pulse signal for controlling the subsequent drive circuit. The pulse frequency is changed by adjusting the resistor and capacitor. Drive module: MOSFET is used as a switching element to control a large current load. The drive circuit contains a protection diode and a filter capacitor. Output module: the output terminal is connected to the load to provide a stable DC power supply, and the output voltage is adjusted by the voltage regulator circuit to ensure the stability of the output voltage. Protection and indication module: fuses and varistors are used to provide overcurrent and overvoltage protection. LED indicators are used to display the power status. Other components: components such as resistors, capacitors and diodes are used for circuit stability and protection.

[0023] Furthermore, the microcontroller circuit uses the STC8H3K64S4-LQFP48 microcontroller to control the entire system, and the various pins of the microcontroller are connected to different peripheral circuits, such as key input, digital tube display, communication interface, etc. Key input module: multiple keys are connected to the P0 port of the microcontroller for user input. The functions of the keys include mode selection, parameter adjustment, etc. Display module: a digital tube is used to display the system status and parameters. The digital tube is connected to the microcontroller through a driver chip. Communication module: a MAX3232 chip is used for serial communication to convert the TTL level to the RS-232 level. The communication interface is used to exchange data with external devices. Drive module: MOSFET is used as a switching element to control a large current load. The drive circuit contains a protection diode and a filter capacitor. Power supply module: provides +5V and -5V power supplies for the microcontroller and other components. The power supply circuit contains a voltage regulator diode and a filter capacitor. Indication module: an LED is used to indicate the system operation status. Other components: components such as resistors, capacitors and diodes are used for circuit stability and protection.

[0024] Furthermore, the integrated stimulation coil includes a parallel double-turn Helmholtz coil, which can generate a uniform magnetic field, and the inner diameter of the coil is The outer diameter is The distance between the two coils is 130 mm.

[0025] Furthermore, the air cooling system is composed of a cooling fan.

[0026] The control host can modulate and change the electromagnetic stimulation parameters, which requires manual operation. At the same time, because the effective value of the stimulation intensity of extremely low frequency magnetic field bioelectromagnetic stimulation varies depending on the stimulated organism, the effective stimulation intensity required by different subjects varies greatly. First, the stimulation intensity is calculated to be near the pain threshold, and its stimulation intensity is determined to change other stimulation parameters such as AC frequency, duty cycle, time, etc.

[0027] System operation instructions:

[0028] After the machine is powered on, the mode displays "01", the intensity displays "10", and the timing displays "60:00". Press the "Mode +" button to increase the mode display by 1, and press the "Mode -" button to decrease the mode display by 1; press the "Intensity +" button to increase the intensity display by 1, and press the "Intensity -" button to decrease the intensity display by 1; press the "Timing" button once, and the timing displays "45:00". Press the "Timing" button again, and the timing displays "30:00". Continue to press the "Timing" button, and the timing cycle displays "60:00". The timing is divided into three levels: 30 minutes, 45 minutes, and 60 minutes.

[0029] Sine wave mode operation: long press the "Start / Stop" button of the sine wave mode, the sine wave mode indicator light will light up, the sine wave mode will start to work, output sine wave signal, the timing display of the sine wave mode will start to count down, when the timing display reaches "00:00", it will automatically stop working, the indicator light will go out, and the display will return to the state before starting. During the working process, long press the "Start / Stop" button of the sine wave mode to stop working. Whether it is automatic stop or manual stop, there will be a buzzer sound.

[0030] Pulse mode operation: long press the pulse mode "start and stop" button, the pulse mode indicator light is on, the pulse mode starts to work, outputs pulse signals, and the pulse mode timing display starts to count down. When the timing display reaches "00:00", it automatically stops working, the indicator light goes out, and the display returns to the state before starting. During the working process, long press the pulse mode "start and stop" button to stop working. Whether it is automatic stop or manual stop, it is accompanied by a buzzer sound.

[0031] Waveform output example:

[0032] Table 1 Sine waveform (part)

[0033] Mode Number Cycle(s) Strength (mT) Duty cycle (%) Mode 01 2 5 50 Mode 05 10 3 30

[0034] Table 2 Pulse waveform (part)

[0035]

[0036] Operation Tips:

[0037] 1. When the sine wave mode is working, the pulse mode operation is invalid. Only when the sine wave mode is stopped and the indicator light goes out, can the pulse mode operation be performed. Similarly, when the pulse mode is working, the sine wave mode operation is also invalid.

[0038] 2. Whether working in sine wave mode or pulse mode, the cooling fan on the stimulation coil must be in working state to prevent the temperature inside the stimulation coil from being too high. The cooling fan can only be turned off to reduce noise when working for a short time.

[0039] 3. Whether it is sine wave mode or pulse mode, the mode selection needs to be made in the non-working state. The mode operation is invalid in the working state.

[0040] Any matters not described in the present invention are applicable to the prior art.

Claims

1. A bio-electromagnetic stimulation system based on an extremely low frequency magnetic field, characterized in that: It includes a control host, an integrated stimulation coil and an air cooling system; the integrated stimulation coil is composed of two parallel Helmholtz coils, which are used to generate a uniform magnetic field; the air cooling system is integrated inside the Helmholtz coil to reduce the working temperature of the coil; the control host includes an operation panel, a single-chip microcomputer circuit, a power supply circuit, a sine wave control circuit, a pulse control circuit and a host computer serial interface, and the operation panel has mode selection, intensity adjustment, and timing setting buttons; The single chip microcomputer circuit is responsible for the control of the entire system, the sine wave control circuit is used to output a sine wave waveform, and the pulse control circuit is used to output a pulse waveform.

2. The bioelectromagnetic stimulation system based on extremely low frequency magnetic field according to claim 1, characterized in that: The power supply circuit includes a power input module, a rectification and filtering module, a voltage stabilizing module, a control module, a driving module, and a protection and indication module; the power input module connects a 220V AC power supply and a DC power supply through a power input terminal and converts the 220V AC power into AC power through a transformer; the rectification and filtering module converts the AC power into DC power through a rectifier bridge, and filters the rectified DC power through a filter capacitor; the voltage stabilizing module stabilizes the filtered DC power to 5V and 12V through a voltage stabilizing IC; the control module is used to generate a pulse signal and change the pulse frequency by adjusting the resistor and the capacitor; the driving module uses MOSFET as a switching element to control a large current load; the protection and indication module uses a fuse and a varistor to provide overcurrent and overvoltage protection.

3. The bioelectromagnetic stimulation system based on extremely low frequency magnetic field according to claim 1, characterized in that: The system includes two stimulation modes: sine wave mode and pulse mode; the sine wave mode includes multiple preset modes, which are adjusted by changing the period, magnetic field strength and duty cycle; the pulse mode includes multiple preset modes, which output different waveforms by changing the frequency and magnetic field strength.

4. The bioelectromagnetic stimulation system based on extremely low frequency magnetic field according to claim 3, characterized in that: The sine wave mode outputs a low-frequency magnetic field of 2s-16s, which promotes cerebral vasodilation, improves brain blood circulation, increases brain blood flow, and improves brain cell metabolism.

5. The bioelectromagnetic stimulation system based on extremely low frequency magnetic field according to claim 3 or 4, characterized in that: The pulse mode outputs a 10-50Hz pulse signal, which activates nerve conduction, quickly repairs damaged brain cells, and promotes the recovery of nerve function.

6. The bio-electromagnetic stimulation system based on extremely low frequency magnetic field according to claim 3, characterized in that: The combination of sine wave mode and pulse mode can improve blood circulation in the lesion area, reduce sclerosis of cerebral vascular walls, and enhance the self-repair ability of damaged cells.

7. The bio-electromagnetic stimulation system based on extremely low frequency magnetic field according to claim 1, characterized in that: The air cooling system includes an air cooling fan.

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