Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases as well as preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and a preparation method and application thereof, and the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 16 parts of maltitol, 4 parts of ginseng, 16 parts of sophora flower, 16 parts of hawthorn, 16 parts of ginkgo, 2 parts of spina date seed, 26 parts of kudzuvine root and 4 parts of peach kernel. The traditional Chinese medicine composition disclosed by the invention can be used for effectively estimating or treating cardiovascular and cerebrovascular diseases, especially coronary heart diseases.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases, and a preparation method and application thereof. Background Art

[0002] Cardiovascular and cerebrovascular diseases have become the most important diseases threatening human health and life. In the prevention and treatment of cardiovascular and cerebrovascular diseases, although modern medical interventional therapy, surgical operations, statin lipid-lowering drugs, antiplatelet agents and thrombolytic agents have been used in clinical practice, the efficacy is not ideal.

[0003] Vascular stenosis is the most direct cause of cardiovascular and cerebrovascular diseases. Due to blood lipids, inflammation and other reasons, plaques accumulate, causing vascular stenosis, which further leads to insufficient blood supply, bleeding, changes in blood pressure and blood flow, and the formation of cardiovascular and cerebrovascular diseases. Therefore, controlling or reducing vascular stenosis is a conventional way to prevent or treat cardiovascular and cerebrovascular diseases. Interventional therapy, surgical operations, statins, antiplatelet agents and thrombolytic agents are actually used to control or reduce vascular stenosis.

[0004] At present, Western medicine is mostly used in the clinical treatment of patients with cardiovascular and cerebrovascular diseases. The drugs used include cardiotonic drugs, diuretics, angiotensin-converting enzyme inhibitors, etc. The patient's symptoms can be effectively improved after treatment, but patients are more likely to have adverse reactions during treatment, and the disease control effect of some patients after taking the medicine is not ideal. Therefore, it is necessary to explore more effective therapeutic drugs.

[0005] In contrast, traditional Chinese medicine has fewer toxic and side effects in preventing and treating cardiovascular diseases, and can effectively improve patients' clinical symptoms, stabilize or reduce plaques, alleviate inflammatory responses, and improve myocardial blood supply. Therefore, the present invention provides a traditional Chinese medicine composition and a preparation method thereof to treat cardiovascular and cerebrovascular diseases and prevent the occurrence of adverse cardiovascular and cerebrovascular events. Summary of the invention

[0006] In view of the above-mentioned technical deficiencies, the purpose of the present invention is to provide a Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, which can effectively treat cardiovascular and cerebrovascular diseases, especially can effectively control or reduce vascular stenosis, thereby effectively alleviating coronary heart disease, angina pectoris, vascular headache, cerebral hemorrhage risk and other diseases caused by cardiovascular and cerebrovascular stenosis.

[0007] In order to solve the above technical problems, the present invention adopts the following technical solutions: The invention provides a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases. The traditional Chinese medicine composition is prepared from the following raw materials in proportion by weight: 13-19 parts by weight of maltitol, 2-6 parts by weight of ginseng, 13-19 parts by weight of sophora japonica flower, 13-19 parts by weight of hawthorn, 13-19 parts by weight of ginkgo, 13-19 parts by weight of spina jujuba seeds, 22-30 parts by weight of kudzu root, and 2-6 parts by weight of peach kernel.

[0008] The present invention provides a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases. The traditional Chinese medicine composition is prepared from the following raw materials in proportion by weight: 16 parts by weight of maltitol, 4 parts by weight of ginseng, 16 parts by weight of sophora japonica flower, 16 parts by weight of hawthorn, 16 parts by weight of ginkgo, 2 parts by weight of spina jujuba seeds, 26 parts by weight of kudzu root, and 4 parts by weight of peach kernel.

[0009] The Chinese medicine composition of the present invention can be prepared into a dosage form suitable for use in cardiovascular and cerebrovascular diseases, specifically, it can be prepared into an oral dosage form or a non-oral dosage form, the non-oral dosage form can be an injection, a transdermal agent, a suppository, a spray, etc., and the oral dosage form can be a tablet, a capsule, an oral liquid, a decoction, a granule, etc.

[0010] The raw materials of the Chinese medicine composition of the present invention can be extracted by conventional extraction methods in the art, specifically, water decoction extraction, ethanol reflux extraction, ethanol percolation extraction, water extraction and alcohol precipitation, and alcohol extraction and water precipitation. Furthermore, part of the raw materials can be extracted, and part of the raw materials can be directly crushed for use.

[0011] Preferably, the present invention also relates to a method for preparing the above-mentioned traditional Chinese medicine tablets for treating cardiovascular and cerebrovascular diseases, characterized in that it comprises the following steps: Step 1: Material selection: The selected materials are all full-grained, uniform in size, free of insects, mold, and unripe fruits; Step 2, washing: put ginseng, Sophora japonica, hawthorn, ginkgo, sour almond, kudzu root, and peach kernel in clean water, and wash to remove the mud and impurities on the surface of the medicine; Step 3, rinsing: repeatedly rinsing the above-mentioned original medicine with a large amount of clean water, changing the water frequently, can rinse away the smell of these original medicines; Step 4, calcining: directly calcine the above raw medicine through a dryer to make it crisp, easy to crush, and give full play to its efficacy; Step 5, powdering: grinding the above raw medicine into powder with a grinder; Step 6, raw material mixing: the above-mentioned original drugs are mixed uniformly according to the following weight proportions: 16 weight parts of maltitol, 4 weight parts of ginseng, 16 weight parts of Sophora japonica, 16 weight parts of hawthorn, 16 weight parts of ginkgo, 2 weight parts of spiny jujube seeds, 26 weight parts of kudzu root, and 4 weight parts of peach kernel; Step 7, increasing the humidity of the above raw materials to make soft materials; Step 8, granulation and drying: remove moisture from the original drug, increase the surface temperature of the original drug by appropriately increasing the air temperature, accelerate the evaporation rate of moisture in the original drug, and ensure the effectiveness of drying; Step 9, granulation and mixing: sieve the dried granules, remove large particles and mix them evenly; Step 10, preparing the preparation: preparing the semi-finished product obtained in step 9 into an oral dosage form or a non-oral dosage form.

[0012] The present invention also relates to the pharmaceutical use of the traditional Chinese medicine composition, and in particular, to the use of the traditional Chinese medicine composition in preparing drugs for preventing or treating cardiovascular and cerebrovascular diseases.

[0013] Preferably, the use of the traditional Chinese medicine composition in the preparation of a drug for preventing or treating cardiovascular and cerebrovascular diseases is characterized in that the cardiovascular and cerebrovascular diseases are one or more of coronary heart disease, angina pectoris, vascular headache, and risk of cerebral hemorrhage.

[0014] More preferably, the use of the traditional Chinese medicine composition in the preparation of a drug for preventing or treating cardiovascular and cerebrovascular diseases is characterized in that the cardiovascular and cerebrovascular diseases are coronary heart disease.

[0015] More specifically, it relates to the use of the traditional Chinese medicine composition in the preparation of a drug for controlling or reducing vascular stenosis.

[0016] Preferably, the use of the traditional Chinese medicine composition in the preparation of a drug for controlling or reducing vascular stenosis is characterized in that the vascular stenosis is coronary artery stenosis.

[0017] The beneficial effects of the present invention are: 1) The Chinese medicine composition of the present invention can effectively prevent and treat cardiovascular and cerebrovascular diseases. Specifically, the Chinese medicine composition of the present invention can effectively control or reduce vascular stenosis, thereby effectively alleviating coronary heart disease, angina pectoris, vascular headache, cerebral hemorrhage risk and other diseases caused by cardiovascular and cerebrovascular stenosis. 2) The components of the present invention are taken from natural medicinal materials, with small toxic and side effects. It is not easy to have adverse reactions while treating the symptoms of patients, and prevent the occurrence of cardiovascular and cerebrovascular adverse events. 3) The Chinese medicine composition shown in this application is mainly composed of ginseng, which replenishes vital energy, strengthens the spleen and lungs, and enhances the body's immunity; Sophora japonica and hawthorn clear away heat and cool blood, digest food and eliminate accumulation, and assist in the treatment of damp-heat syndrome; Ginkgo and Ziziphus jujuba seeds calm the mind and calm the nerves, astringe and consolidate, Pueraria root raises yang and stops diarrhea, peach kernels promote blood circulation and remove blood stasis, and maltitol is added to moisten the lungs and spleen to harmonize the various medicines; the combination of the various medicines can play the role of replenishing qi and strengthening the spleen, clearing away heat and detoxifying, promoting blood circulation and removing blood stasis, and has a good effect on the treatment of cardiovascular and cerebrovascular diseases. 4) In order to verify the clinical effect, patients with coronary artery stenosis were selected as research subjects. The results showed that the Chinese medicine composition of the present application has a significant therapeutic effect in controlling and alleviating coronary artery stenosis. A clinical study of 20 patients showed that it can effectively alleviate coronary artery stenosis with an effective rate of 85%.

[0018] The beneficial effects of the present invention are further described below in combination with the main components of the present invention: Ginseng: [Nature and flavor] Warm in nature, sweet, slightly bitter, slightly warm. Enters the spleen and lung meridians. [Effects and functions] Greatly replenishes vital energy, restores pulse and consolidates collapse, replenishes spleen and lungs, promotes body fluid, and calms the mind. Used for weakness and collapse, cold limbs and weak pulse, spleen deficiency and poor appetite, lung deficiency, wheezing and coughing, and thirst due to loss of body fluid.

[0019] Sophora japonica flower: [Nature and flavor] Bitter, slightly cold. Enters the liver and large intestine meridians. [Effects and functions] Cools blood and stops bleeding, clears the liver and purges fire. Used for blood in stool, hemorrhoids, bloody diarrhea, metrorrhagia, vomiting blood, epistaxis, liver heat and red eyes, headache and dizziness.

[0020] Hawthorn: [Nature and flavor] Sour and sweet, slightly warm. Enters the spleen, stomach, and liver meridians. [Effects and functions] It can eliminate food stagnation, dissipate blood stasis, and expel tapeworms. It can treat meat stagnation, abdominal masses, phlegm and fluid retention, fullness, acid regurgitation, diarrhea, intestinal wind, low back pain, hernia, postpartum occipital pain, lochia retention, and milk and food stagnation in children. It can help digestion and invigorate the stomach, and promote qi and dissipate blood stasis. It is used for meat stagnation, gastric stagnation, diarrhea and abdominal pain, blood stasis amenorrhea, postpartum stasis, heart and abdomen pain, hernia pain, and hyperlipidemia.

[0021] Ginkgo: [Effects and Functions] Ginkgo has the effects of astringing the lungs and calming asthma, stopping leukorrhea, and reducing urination. It is mainly used to treat asthma, leukorrhea, leukorrhea, spermatorrhea, frequent urination and other diseases.

[0022] Ziziphus jujuba seed: [Nature and flavor] Sweet, neutral. Enters the heart, spleen, liver, and gallbladder meridians. [Effects and functions] Nourishes the liver, calms the mind, soothes the nerves, and reduces sweating. Treats insomnia, palpitations, thirst, and sweating.

[0023] Pueraria root: [Nature and flavor] Sweet, pungent, cool. Enters the spleen, stomach, and lung meridians. [Effects and functions] Relieves muscle heat, relieves rash, promotes the production of body fluids and quenches thirst, raises yang and stops diarrhea, promotes blood circulation and activates collaterals, and relieves alcohol poisoning. Used for exogenous fever and headache, stiff neck and back pain, thirst, thirst, measles that does not break out, heat dysentery, diarrhea, dizziness and headache, hemiplegia caused by stroke, chest pain, and alcohol poisoning.

[0024] Peach kernel: [Nature and flavor] Bitter, sweet, neutral. Enters the heart, liver, and large intestine meridians. [Effects and functions] Promotes blood circulation and removes blood stasis, moistens the intestines and promotes bowel movements, relieves cough and relieves asthma. Used for amenorrhea, dysmenorrhea, abdominal masses, lung and intestinal abscesses, injuries from falls, constipation due to dry intestines, and cough and asthma. DETAILED DESCRIPTION

[0025] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention. Example

[0026] A traditional Chinese medicine tablet for treating cardiovascular and cerebrovascular diseases is prepared from the following raw materials by weight: 16 grams of maltitol, 4 grams of ginseng, 16 grams of Sophora japonica flower, 16 grams of hawthorn, 16 grams of ginkgo, 2 grams of spinach seed, 26 grams of kudzu root, and 4 grams of peach kernel.

[0027] The preparation method of the Chinese medicine tablet in this embodiment comprises the following steps: Step 1: Material selection: The selected materials are all full-grained, uniform in size, free of insects, mold, and unripe fruits; Step 2, washing: put ginseng, Sophora japonica, hawthorn, ginkgo, sour almond, kudzu root, and peach kernel in clean water, and wash to remove the mud and impurities on the surface of the medicine; Step 3, rinsing: repeatedly rinsing the above-mentioned original medicine with a large amount of clean water, changing the water frequently, can rinse away the smell of these original medicines; Step 4, calcining: directly calcine the above raw medicine through a dryer to make it crisp, easy to crush, and give full play to its efficacy; Step 5, powdering: grinding the above raw medicine into powder with a grinder; Step 6, raw material mixing: 4 grams of ginseng, 16 grams of Sophora japonica, 16 grams of hawthorn, 16 grams of ginkgo, 2 grams of spiny jujube seeds, 26 grams of kudzu root, 4 grams of peach kernel, and 16 grams of maltitol are mixed evenly; Step 7, increasing the humidity of the above raw materials to make soft materials; Step 8, granulation and drying: remove moisture from the original drug, increase the surface temperature of the original drug by appropriately increasing the air temperature, accelerate the evaporation rate of moisture in the original drug, and ensure the effectiveness of drying; Step 9, granulation and mixing: sieve the dried granules, remove large particles and mix them evenly; Step 10, tableting production: control the tablet press pressure to perform tableting.

[0028] Experimental example (clinical study on patients with coronary artery stenosis)

[0029] In order to verify the clinical effect of the Chinese medicine composition of the present invention on patients with cardiovascular and cerebrovascular diseases, especially vascular stenosis, patients with coronary artery stenosis were selected as research subjects, considering that there are a large number of patients with coronary artery stenosis and that coronary artery stenosis is also easy to observe changes before and after treatment through corresponding non-invasive clinical examinations.

[0030] Experimental subjects: Clinical patients with symptoms of coronary heart disease were selected and enrolled after the diagnosis and confirmation of the presence of coronary artery stenosis. A total of 20 patients were selected for clinical observation and statistics.

[0031] Diagnostic criteria: Clinical symptoms: typical angina pectoris, exertional angina pectoris, chest tightness and pain after activity, shortness of breath, dizziness, fatigue, etc.

[0032] Physical examination: The heart is enlarged, and the heart sounds are low and dull with murmurs.

[0033] Furthermore, the diagnosis is made through electrocardiogram, echocardiogram, coronary angiography and other examinations. The degree of coronary artery stenosis is divided into four levels according to the reduction of the lumen area: Grade I lesions, lumen area reduction of 1% to 25%; Grade II lesions, with a 26% to 50% reduction in lumen area; Grade III lesions, lumen area reduction of 51% to 75%; In grade IV lesions, the lumen area is reduced by 76% to 100%.

[0034] If the degree of stenosis reaches grade three, we can diagnose coronary heart disease.

[0035] Experimental plan: For ethical reasons, a blank control group was not set up, and the coronary artery stenosis of the patients before and after medication was used for self-control. That is, 100% of the 20 patients had coronary artery stenosis before the experiment. If the coronary artery stenosis of the patient is controlled or reduced after 1-3 courses of treatment (i.e. 2-6 months), it can be considered that a certain therapeutic effect has been achieved. The specific efficacy criteria are as follows.

[0036] Efficacy criteria: Cured: Coronary artery stenosis disappeared.

[0037] Marked effect: The degree of coronary artery stenosis is reduced by more than half. For example, if the degree of artery stenosis before treatment is 30% and after treatment is 14%, it can be judged as markedly effective.

[0038] Effective: The degree of coronary artery stenosis remains unchanged, or is reduced, but the reduction is less than half.

[0039] Ineffective: Increased degree of coronary artery stenosis.

[0040] The results showed that the Chinese medicine composition of the present application has a significant therapeutic effect in controlling and alleviating coronary artery stenosis; The results showed that after treatment with the Chinese medicine composition of the present application, 15% of the patients had completely disappeared coronary artery stenosis. In 35% of the patients, the degree of coronary artery stenosis was significantly reduced, and the patients' related chest tightness, chest pain and other symptoms were also basically relieved. The effective patients accounted for 40%, of which 6 patients had a certain degree of reduction in coronary artery stenosis, and 2 patients had the same degree of coronary artery stenosis without progressive aggravation. In addition, no efficacy was observed in 10% of the patients, which may be related to the deeper degree of coronary artery stenosis in the relevant patients.

[0041] Typical cases: Some typical cases are selected below to further illustrate the therapeutic effect of the Chinese medicine preparation of the present invention.

[0042] 1. Ms. Wu, 46 years old, had an examination at Zhengzhou Ruijin Chinese Medicine Hospital on May 19, 2024. The results are as follows: Mild to moderate stenosis (30%~50%) of the left anterior descending coronary artery (LAD); Severe stenosis (80%) of the left anterior descending coronary artery (D1); Mild to moderate stenosis (30%~55%) of the left circumflex coronary artery (LCX); Moderate stenosis (60%) of the right posterior descending coronary artery (PDA); After taking the product for 56 days, the patient was examined at Linhe District People's Hospital on July 16, 2024 as follows: No stenosis was found in the left anterior descending coronary artery (LAD); No stenosis was found in the left anterior descending coronary artery (D1); No stenosis was found in the left circumflex coronary artery (LCX); No stenosis was found in the posterior descending right coronary artery (PDA).

[0043] 2. Mr. Wang, 53 years old, had an examination at Xinxiang Central Hospital on July 12, 2023. The results are as follows: Anterior descending branch stenosis is approximately 9.1%-31.3%; Circumflex artery stenosis is approximately 11.1%-12.5%; The right coronary artery stenosis is about 27.3%-62.5%; After taking the product for about 100 days, the patient was examined at Yuanyang New Oriental Hospital on November 25, 2023 as follows: No obvious stenosis was found in the anterior descending branch; No obvious stenosis was found in the circumflex artery; No obvious stenosis was found in the right coronary artery.

[0044] 3. Mr. Yun, 56 years old, had an examination at the Etuoke Banner Mongolian Medicine General Hospital on April 24, 2024. The results are as follows: Mild left main stenosis <25%; The left anterior descending artery is proximal and the middle segment is slightly narrowed by 25%-50%; The circumflex branch is proximal and the middle segment is slightly narrowed <25%; The right coronary artery proximal and mid-segment had a slight stenosis of 25%-50%; After taking the product for 96 days, the following examination results were obtained at the Otog Banner Mongolian Medicine General Hospital on July 30, 2024: No plaques or significant stenosis were found in the left main trunk; The left anterior descending artery was proximal, with no plaque or obvious stenosis cleared in the middle segment; The circumflex branch was close, and no plaque or obvious stenosis was found in the middle segment; There was no plaque or obvious stenosis in the proximal and middle segments of the right coronary artery.

[0045] 4. Ms. Zhang, 43 years old, had a check-up at Xinxiang Central Hospital on July 7, 2023. The results are as follows: The wall of the anterior descending branch is rough and not smooth, and the local stenosis is about 37.5%-42.9%; The wall of the circumflex branch is not smooth, and the stenosis of the middle and distal segments is about 20.9%-45.1%; The right coronary artery has an uneven wall and local stenosis of about 11.1%-22.2% in the middle and distal segments; After taking the product for 120 days, the patient was examined at Xinxiang Central Hospital on November 24, 2023 as follows: The walls of the anterior descending branch and circumflex branch are still smooth and no obvious stenosis has been cleared; The walls of the middle and distal segments of the right coronary artery were smooth and no obvious stenosis was found.

[0046] 5. Mr. Shi, 56 years old, had an examination at Xiangcheng First People's Hospital on August 21, 2024. The results are as follows: Non-calcified plaques were observed in the middle segment of the left anterior descending artery, with mild stenosis of about 28% and a stenosis length of 8.7 mm; Non-calcified plaques were observed in the middle segment of the right coronary artery, with a mild stenosis of about 43% and a stenosis length of 9.3 mm; A localized non-calcified plaque was observed in the right posterior descending branch, with a moderate stenosis of approximately 58% and a stenosis length of 4.8 mm.

[0047] After taking the product for 55 days, the patient was examined at Xiangcheng First People's Hospital on October 16, 2024 as follows: No plaques or stenosis were found in the left anterior descending artery; No plaque was found in the right coronary artery and the stenosis was cleared; No obvious abnormalities were found in the coronary arteries.

[0048] 6. Mr. Yan, 67 years old, had an examination at Luyi Cardiovascular Hospital on April 27, 2024. The results are as follows: Moderate stenosis of the proximal anterior descending artery is about 50%-60%; Mild to moderate stenosis of the proximal circumflex artery is about 40%-55%; The right coronary artery proximal segment has a mild to moderate stenosis of about 40% to 50% due to calcified plaque; After taking the product for 6 months, the following examination results were obtained at Luyi Cardiovascular Hospital on November 13, 2024: There was no obvious abnormal stenosis and dilatation of the anterior descending branch, and the lumen returned to normal; There was no obvious abnormal stenosis and dilatation of the circumflex branch, and the lumen returned to normal; There is calcified plaque on the proximal wall of the right coronary artery, and the lumen has returned to normal without stenosis.

[0049] From the above typical cases, it can be seen that taking the Chinese medicine formula shown in the present invention for 2 months has a significant improvement effect on cardiovascular and cerebrovascular diseases, and taking it for 4-6 months can effectively treat cardiovascular and cerebrovascular diseases, which is a significant improvement compared to existing treatment methods.

[0050] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these modifications and variations.

Claims

1. A Chinese medicine composition for treating cardiovascular and cerebrovascular diseases, characterized in that: The invention is prepared from the following raw materials in parts by weight: 13-19 parts by weight of maltitol, 2-6 parts by weight of ginseng, 13-19 parts by weight of Sophora japonica flower, 13-19 parts by weight of hawthorn, 13-19 parts by weight of ginkgo, 13-19 parts by weight of spinosa jujube kernel, 22-30 parts by weight of kudzu root and 2-6 parts by weight of peach kernel.

2. A method for preparing a Chinese medicine composition for treating cardiovascular and cerebrovascular diseases, characterized in that: The steps include: Step 1: Material selection: The selected materials are all full-grained, uniform in size, free of insects, mold, and unripe fruits; Step 2, washing: put ginseng, Sophora japonica, hawthorn, ginkgo, sour almond, kudzu root, and peach kernel in clean water, and wash to remove the mud and impurities on the surface of the medicine; Step 3, bleaching: the above-mentioned original medicine is repeatedly soaked and bleached with a large amount of clean water, and the water is changed to rinse off the smell of these original medicines; Step 4, calcining: directly calcining the above raw medicine through a dryer to make it crispy and easy to crush, so as to give full play to its efficacy; Step 5, powdering: grinding the above raw medicine into powder with a grinder; Step 6, raw material mixing: the above-mentioned original drugs are mixed uniformly according to the following weight proportions: 16 weight parts of maltitol, 4 weight parts of ginseng, 16 weight parts of Sophora japonica, 16 weight parts of hawthorn, 16 weight parts of ginkgo, 2 weight parts of spiny jujube seeds, 26 weight parts of kudzu root, and 4 weight parts of peach kernel; Step 7, increasing the humidity of the above raw materials to make soft materials; Step 8, granulation and drying: remove moisture from the original drug, increase the surface temperature of the original drug by appropriately increasing the air temperature, accelerate the evaporation rate of moisture in the original drug, and ensure the effectiveness of drying; Step 9, producing whole granules and mixing: sieving the dried granules, removing large particles and mixing them evenly to obtain a semi-finished product; Step 10, preparing the preparation: preparing the semi-finished product obtained in step 9 into an oral dosage form or a non-oral dosage form.

3. The method for preparing the Chinese medicine composition for treating cardiovascular and cerebrovascular diseases according to claim 2, characterized in that: The non-oral dosage forms include injections, transdermal preparations, suppositories and sprays, and the oral dosage forms include tablets, capsules, oral liquids, decoctions and granules.

4. An application of a Chinese medicine composition for treating cardiovascular and cerebrovascular diseases, applied to the Chinese medicine composition for treating cardiovascular and cerebrovascular diseases according to any one of claims 1 to 3, characterized in that: The cardiovascular and cerebrovascular diseases include coronary heart disease, angina pectoris, vascular headache, and risk of cerebral hemorrhage; Preferably, the cardiovascular and cerebrovascular disease is coronary heart disease.

5. The use of the Chinese medicine composition for treating cardiovascular and cerebrovascular diseases as claimed in claim 4, characterized in that: The Chinese medicine composition is used in preparing a drug for controlling or reducing vascular stenosis, wherein the vascular stenosis is coronary artery stenosis.