Tendon hanging paste and preparation method thereof

By using a hanging rib cream containing a variety of Chinese herbal medicines, the problem of trauma that causes deep hematoma and inflammatory reactions is difficult to eliminate, and the effect of quickly relieving swelling and pain, eradicating deep hematoma and reducing inflammatory reactions is achieved, reducing the patient's pain and treatment cycle.

CN119857131APending Publication Date: 2025-04-22SHANGHAI PUTUO DISTRICT PEOPLES HOSPITAL
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Patent Information

Application Number
CN202510123224.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-01-26
Publication Date
2025-04-22

AI Technical Summary

Technical Problem

The prior art is difficult to quickly and effectively eliminate deep hematoma and inflammatory reactions caused by trauma, and traditional plasters have no radical effect on deep hematoma, and the treatment cycle is long and the patient suffers a lot.

Method used

A kind of sling cream is used, and its formula includes Chinese herbal medicine such as bone-transparent grass, safflower, asarum, yam, lilac, angelica, raw rhubarb, raw licorice, raw gardenia, Qianghuo, blood exhaustion, frankincense, myrrh, hemu, blood charcoal, raw gypsum, Duhuo, camphor and bauhinia skin, etc., which are made by grinding, screening treatment and mixing machine, and adding malt sugar to stir.

Benefits of technology

This hanging rib ointment can quickly relieve swelling and pain caused by trauma and blood stasis, eradicate deep hematoma, reduce inflammatory response, shorten the course of treatment, avoid surgical treatment, and relieve patients' pain.

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Abstract

The invention provides a tendon hanging paste and a preparation method thereof, relates to the technical field of traditional Chinese medicines, and provides a plaster for treating swelling and pain, hematoma and extravasated blood caused by trauma including fracture, soft tissue injury, traumatic injury and the like, and a plaster suitable for relieving chronic cervical and lumbar disc herniation. The plaster disclosed by the invention has the advantages of strong permeability and absorbability, quick response, short treatment course, high curative effect and few side effects, can radically treat swelling, hematoma and extravasated blood diseases caused by trauma, eliminate hematoma and reduce inflammatory response, and can avoid surgical treatment, shorten the treatment course of a patient and relieve the pain of the patient.
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Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine, and in particular to a tendon-hanging plaster and a preparation method thereof. Background Art

[0002] Due to trauma, including fractures, soft tissue injuries, and contusions, the affected area is prone to swelling, bruising, and severe pain, and the patient's activities are limited. The current treatment method is that when the hematoma is not large, you can use a hot water bottle or hot towel for hot compresses, use anti-inflammatory drugs for treatment, or apply blood circulation and blood stasis plasters to let the hematoma dissipate on its own. However, traditional plasters only have a simple blood circulation and blood stasis effect, have no radical effect on deep hematomas, and the onset time varies. For deep hematomas caused by trauma, hematomas often gather in the deep and are difficult to dissipate. In clinical practice, surgical measures are generally taken, which require puncture and extraction, and local compression and bandaging. If the patient refuses surgery, the patient can only wait for the hematoma to slowly dissipate and be absorbed, commonly known as "it takes 100 days to heal a broken bone". The patient suffers from continuous pain, the patient suffers a lot, and the healing period is relatively long.

[0003] Therefore, it is necessary to find a medicine that has good therapeutic effect, quick effect, eliminates hematoma and relieves pain in patients. Summary of the invention

[0004] The technical problem solved by the present invention is to provide a muscle suspension plaster, which can quickly relieve swelling caused by traumatic blood stasis, relieve pain, and eradicate deep hematomas, reduce inflammatory reactions, shorten the course of treatment, and avoid surgical treatment to relieve the patient's pain. Specifically, the technical solution of the present invention includes the following contents:

[0005] One of the purposes of the present invention is to provide a method for preparing a muscle suspension plaster, the preparation method comprising the following steps:

[0006] 2-5 parts by weight of Radix Angelicae Pubescentis, 2-5 parts by weight of safflower, 2-5 parts by weight of asarum, 1-3 parts by weight of galangal, 1-3 parts by weight of clove, 2-5 parts by weight of angelica, 0.3-0.8 parts by weight of raw rhubarb, 1-3 parts by weight of raw liquorice, 2-5 parts by weight of raw gardenia, 2-5 parts by weight of notopterygium wilfordii, 0.6-1.2 parts by weight of dragon's blood, 2-5 parts by weight of frankincense, 2-5 parts by weight of myrrh, 2-5 parts by weight of sappan wood, 2-5 parts by weight of charcoal, 1-3 parts by weight of gypsum, 2-5 parts by weight of angelica pubescens, 1-3 parts by weight of camphor and 3-7 parts by weight of redbud bark are mixed and ground, sieved through a sieve to form fine powder, put into a mixer for mixing to obtain mixed medicinal powder, and maltose is added to the mixed medicinal powder and stirred to obtain the tendon-hanging paste.

[0007] Preferably, calculated by weight, the diaoshin plaster comprises the following Chinese medicines: 3 parts of radix schizonepetae, 3 parts of safflower, 3 parts of asarum, 1.5 parts of galangal, 1.5 parts of cloves, 3 parts of angelica, 0.6 parts of raw rhubarb, 1.5 parts of raw licorice, 3 parts of raw gardenia, 3 parts of notopterygium, 1 part of blood clotting, 3 parts of frankincense, 3 parts of myrrh, 3 parts of sappan wood, 3 parts of blood charcoal, 1.5 parts of gypsum, 3 parts of angelica dahurica, 1.5 parts of camphor and 5 parts of Bauhinia bark;

[0008] Herba pedunculatae has the effects of eliminating rheumatism, promoting blood circulation and relieving pain. It is mainly used to treat rheumatic pain and injuries caused by falls.

[0009] Safflower has the effects of promoting blood circulation, relieving blood stasis and relieving pain. It is mainly used for amenorrhea, dysmenorrhea, lochia retention, lumps and masses, injuries from falls, and sores and swellings.

[0010] Asarum has the effects of dispelling wind and cold, clearing the orifices and relieving pain, warming the lungs and transforming fluid. It is mainly used to treat colds, headaches, toothaches, nasal congestion and sinusitis, rheumatic pain, phlegm and cough.

[0011] Kaempferia galanga has the effects of promoting qi and warming the middle, promoting digestion and relieving pain. It is mainly used for chest distension, cold pain in the abdomen, and indigestion.

[0012] Clove has the effects of warming the middle and lowering adverse reactions, nourishing the kidney and supporting yang. It is mainly used to treat spleen and stomach deficiency and cold, hiccups and vomiting, poor appetite, vomiting and diarrhea, cold pain in the heart and abdomen, kidney deficiency and impotence, etc.

[0013] Angelica sinensis has the effects of nourishing blood, activating blood circulation, regulating menstruation and relieving pain, and moistening the intestines and relieving constipation. It is often used for blood deficiency, sallow complexion, dizziness and palpitations, irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain due to deficiency and cold, constipation due to dry intestines, rheumatic arthralgia, injuries from falls, carbuncle and ulcer;

[0014] Raw rhubarb has the effects of purging and attacking accumulation, clearing away heat and purging fire, cooling blood and detoxifying, removing blood stasis and dredging menstruation, and removing dampness and jaundice. It is mainly used to treat constipation due to excess heat, abdominal pain due to stagnation, diarrhea, jaundice due to damp heat, vomiting and bleeding due to blood heat, red eyes and swollen throat, abdominal pain due to intestinal carbuncle, carbuncle furuncle, amenorrhea due to blood stasis, and traumatic injuries.

[0015] Raw licorice has the effects of tonifying the spleen and replenishing qi, clearing away heat and detoxifying, removing phlegm and relieving cough, relieving urgency and relieving pain, and harmonizing various medicines. It is often used for spleen and stomach weakness, fatigue, palpitations and shortness of breath, cough with sputum, abdominal and limb cramps and pain, carbuncle, sore and poison, and relieves the toxicity and potency of drugs;

[0016] Raw Gardenia has the effects of purging fire and relieving restlessness, clearing away heat and dampness, cooling blood and detoxifying, and externally reducing swelling and relieving pain. It is mainly used to treat fever and restlessness, damp-heat jaundice, stranguria and pain, vomiting and bleeding due to blood heat, red and swollen eyes, fire poison sores, and external treatment of sprains and bruises.

[0017] Qianghuo has the effects of dispelling cold, dispelling wind, removing dampness and relieving pain. It is mainly used to treat colds, headaches, cold and dampness, and shoulder and back pain.

[0018] Xuejie has the effects of removing blood stasis, relieving pain, stopping bleeding and promoting tissue regeneration. It is used for fractures caused by falls, internal injuries, blood stasis and pain, and continuous bleeding caused by external injuries.

[0019] Frankincense has the effects of regulating qi, promoting blood circulation, relieving pain, reducing swelling and promoting tissue regeneration. It is mainly used to treat qi and blood stagnation, pain from falls and injuries, pain from abdominal blood stasis, rheumatic pain, dysmenorrhea, and swollen and painful sores or ulcers that do not heal for a long time.

[0020] Myrrh has the effects of promoting blood circulation and relieving pain, reducing swelling and promoting tissue regeneration. It is used to treat injuries caused by falls, abdominal pain, rheumatic pain, amenorrhea, dysmenorrhea, and swollen and painful sores or ulcers that do not heal for a long time.

[0021] Su Mu has the effects of promoting blood circulation, removing blood stasis, reducing swelling and relieving pain. It is mainly used to treat injuries from falls, fractures and tendon injuries, stasis and swelling, amenorrhea, dysmenorrhea, postpartum blood stasis, chest and abdominal pain, carbuncle swelling and pain;

[0022] Xueyutan has the effects of astringing and stopping bleeding, removing blood stasis, and diuresis. It is mainly used to treat hematemesis, hemoptysis, epistaxis, hematuria, hematuria, hematochezia, metrorrhagia, traumatic bleeding, and urinary incontinence.

[0023] Gypsum has the effects of clearing away heat and purging fire, relieving restlessness and quenching thirst. It is mainly used to treat exogenous febrile diseases, high fever and thirst, lung heat and cough, hyperactivity of stomach fire, headache, and toothache.

[0024] Duhuo has the effects of dispelling wind and dampness, relieving numbness and relieving pain. It is mainly used to treat wind-cold-dampness arthralgia, waist and knee pain, Shaoyin hidden wind headache, and wind-cold-damp headache.

[0025] Camphor has the effects of warding off filth, opening the orifices, killing insects, relieving itching, reducing swelling and relieving pain. It is mainly used to treat mental coma, abdominal distension and pain, beriberi, sores, scabies, toothache, and injuries from falls.

[0026] Bauhinia bark has the effects of promoting blood circulation, reducing swelling and detoxifying. It is often used to treat external ulcers, carbuncles, sores, snake and insect bites, and injuries from falls.

[0027] Furthermore, the specification of the sieve is 100-200 meshes.

[0028] Furthermore, the mixer includes a mixing speed of 10 to 30 rpm and a mixing time of 3 to 10 min.

[0029] Furthermore, the mass ratio of the maltose to the mixed medicinal powder is 10:1-3.

[0030] The second object of the present invention is to provide a muscle-suspending plaster, the dosage form of which includes an ointment and a patch.

[0031] Furthermore, the preparation method of the ointment comprises the following steps:

[0032] The muscle suspension paste is stirred into a paste state, and sealed and packaged to prepare the ointment.

[0033] Furthermore, the preparation method of the patch comprises the following steps:

[0034] 1.5-2 g of the muscle suspension plaster was taken and spread on a 15 cm×15 cm kraft paper, and then covered with a 12 cm×12 cm plastic film to prepare the patch.

[0035] Furthermore, the method for using the ointment comprises the following steps:

[0036] Take 1.5 to 2g of the muscle suspension ointment and apply it directly to the body surface.

[0037] Furthermore, the method for using the patch comprises the following steps:

[0038] Remove the plastic film, apply the sling patch to the injured or painful area, and fix it by wrapping a bandage.

[0039] Furthermore, the method of using the muscle suspension plaster is to apply it directly to the affected area, change it every 24 hours, and apply it continuously for 1 to 3 weeks.

[0040] Furthermore, the storage condition of the muscle suspension plaster is dry storage in a temperature environment of 4 to 7°C.

[0041] Compared with the prior art, the present invention has the following beneficial effects:

[0042] (1) The Chinese medicine selected in the present invention has mild and non-irritating properties and follows the principle of Chinese medicine compatibility. Bauhinia bark is the main medicine, safflower, asarum, angelica, raw gardenia, notopterygium, pubescens, frankincense, myrrh, sappan wood and blood stasis charcoal are the assistant medicines, galangal, clove, raw rhubarb, raw gypsum and dragon's blood are the adjuvant medicines, raw liquorice is the guiding medicine, and camphor is the guiding medicine. The combination of various medicinal materials has the definite effects of promoting blood circulation and removing blood stasis, reducing inflammation and relieving swelling and pain.

[0043] (2) The present invention has the potential to reduce inflammatory response and vascular permeability, and changes blood rheology by affecting vasodilation and blood flow velocity at specific sites. The muscle suspension plaster prepared by the present invention can quickly relieve swelling caused by traumatic blood stasis, relieve pain, and eradicate deep hematoma, reduce inflammatory response, shorten the course of treatment, and avoid surgical treatment, thereby alleviating the patient's pain.

[0044] (3) Compared with the plasters sold on the market, the preparation process of the present invention does not contain adhesives, and patients are less likely to have allergic reactions. Modern people are more prone to allergies, and repeated sticking on damaged parts will damage the skin. The present invention uses maltose to play a sticky role, has simple ingredients, and is suitable for patients with allergies.

[0045] (4) The preparation method of the present invention is simple and suitable for development and production. BRIEF DESCRIPTION OF THE DRAWINGS

[0046] Figure 1 This is the effect of different treatment groups on body weight and food consumption of traumatic blood stasis rats in Experimental Example 1 of the present invention.

[0047] Figure 2 This is the effect of different treatment groups in Experimental Example 2 of the present invention on the leg diameter of rats with trauma and blood stasis.

[0048] Figure 3 HE staining of muscle tissue of traumatic blood stasis rats in different treatment groups in Experimental Example 3 of the present invention. DETAILED DESCRIPTION

[0049] The technical solution of the present invention will be clearly and completely described below through the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present invention.

[0050] Unless otherwise specified, the raw materials and reagents used in the present invention are commercially available or can be prepared by known methods.

[0051] Embodiment 1:

[0052] A method for preparing a muscle-hanging plaster comprises the following steps:

[0053] Mix and grind 300g of Herba schizonepetae, 300g of safflower, 300g of asarum, 150g of galangal, 150g of clove, 300g of angelica, 60g of raw rhubarb, 150g of raw licorice, 300g of raw gardenia, 300g of Notopterygium wilfordii, 100g of Sanguisorba officinalis, 300g of frankincense, 300g of myrrh, 300g of Sappan wood, 300g of Sanguisorba officinalis, 150g of gypsum, 300g of Angelica dahurica, 150g of camphor and 500g of Bauhinia bark, sieve it into fine powder with a 100-mesh sieve, put it into a mixer, set the mixing speed to 30rpm and the mixing time to 10min, and obtain a mixed powder after mixing. Take 30g of the mixed powder, add 100g of maltose, and stir to prepare a tendon-hanging paste.

[0054] Embodiment 2:

[0055] A method for preparing a muscle-hanging plaster comprises the following steps:

[0056] Mix and grind 200g of Herba schizonepetae, 200g of safflower, 200g of asarum, 100g of galangal, 100g of clove, 200g of angelica, 30g of raw rhubarb, 100g of raw licorice, 200g of raw gardenia, 200g of Notopterygium wilfordii, 60g of Sanguisorba officinalis, 200g of frankincense, 200g of myrrh, 200g of Sappan wood, 200g of Sanguisorba officinalis, 100g of gypsum, 200g of Angelica dahurica, 100g of camphor and 300g of Bauhinia bark, sieve it into fine powder with a 200-mesh sieve, put it into a mixer, set the mixing speed to 10 rpm and the mixing time to 3 min, and obtain a mixed powder after mixing. Take 10g of the mixed powder, add 100g of maltose and stir to prepare a tendon-hanging paste.

[0057] Embodiment 3:

[0058] A method for preparing a muscle-hanging plaster comprises the following steps:

[0059] Mix and grind 500g of Herba schizonepetae, 500g of safflower, 500g of asarum, 300g of galangal, 300g of clove, 500g of angelica, 80g of raw rhubarb, 300g of raw licorice, 500g of raw gardenia, 500g of Notopterygium wilfordii, 120g of Sanguisorba officinalis, 500g of frankincense, 500g of myrrh, 500g of Sappan wood, 500g of Sanguisorba officinalis, 300g of gypsum, 500g of Angelica dahurica, 300g of camphor and 700g of Bauhinia bark, sieve into fine powder with a 140-mesh sieve, put into a mixer, set the mixing speed to 15 rpm and the mixing time to 5 min, obtain a mixed powder after mixing, take 15g of the mixed powder, add 100g of maltose and stir to prepare a tendon-hanging paste.

[0060] Embodiment 4:

[0061] A method for preparing a muscle-hanging plaster comprises the following steps:

[0062] Mix and grind 500g of Herba schizonepetae, 500g of safflower, 500g of asarum, 150g of galangal, 150g of clove, 300g of angelica, 60g of raw rhubarb, 150g of raw licorice, 300g of raw gardenia, 300g of Notopterygium wilfordii, 100g of Sanguisorba officinalis, 300g of frankincense, 300g of myrrh, 300g of Sappan wood, 300g of Sanguisorba officinalis, 150g of gypsum, 300g of Angelica dahurica, 150g of camphor and 500g of Bauhinia bark, sieve it into fine powder with a 200-mesh sieve, put it into a mixer, set the mixing speed to 15 rpm and the mixing time to 3 min, and obtain a mixed powder after mixing. Take 20g of the mixed powder, add 80g of maltose and stir to prepare a tendon-hanging paste.

[0063] Application Example 1:

[0064] A method for using a tendon suspension ointment comprises the following steps:

[0065] The muscle-hanging ointment prepared in Example 1 is stirred into a paste, sealed and packaged to prepare a muscle-hanging ointment, which is stored in an environment of 4 to 7° C. When used, 1.5 g of the muscle-hanging ointment is taken and directly applied to the body surface.

[0066] Application Example 2:

[0067] A method for using a tendon suspension ointment comprises the following steps:

[0068] The muscle-hanging ointment prepared in Example 1 is stirred into a paste, sealed and packaged to prepare a muscle-hanging ointment, which is stored in an environment of 4 to 7° C. When used, 1.7 g of the muscle-hanging ointment is taken and directly applied to the body surface.

[0069] Application Example 3:

[0070] A method for using a tendon suspension ointment comprises the following steps:

[0071] The muscle-hanging ointment prepared in Example 1 is stirred into a paste, sealed and packaged to prepare a muscle-hanging ointment, which is stored in an environment of 4 to 7° C. When used, 2 g of the muscle-hanging ointment is taken and directly applied to the body surface.

[0072] Application example 4:

[0073] A method for using a tendon-hanging plaster patch comprises the following steps:

[0074] Take 1.5g of the muscle suspension plaster prepared in Example 1 and spread it on 15cm×15cm kraft paper, cover it with a layer of 12cm×12cm plastic film to make a muscle suspension plaster patch, and store it in an environment of 4-7℃. When using, remove the plastic film, apply the muscle suspension plaster patch to the injured area or painful area, and fix it by wrapping a bandage.

[0075] Application Example 5:

[0076] A method for using a tendon-hanging plaster patch comprises the following steps:

[0077] Take 1.7g of the muscle suspension plaster prepared in Example 1 and spread it on 15cm×15cm kraft paper, cover it with a layer of 12cm×12cm plastic film to make a muscle suspension plaster patch, and store it in an environment of 4-7℃. When using, remove the plastic film, apply the muscle suspension plaster patch to the injured or painful area, and fix it by wrapping a bandage.

[0078] Application Example 6:

[0079] A method for using a tendon-hanging plaster patch comprises the following steps:

[0080] Take 2g of the muscle suspension plaster prepared in Example 1 and spread it on 15cm×15cm kraft paper, cover it with a layer of 12cm×12cm plastic film to make a muscle suspension plaster patch, and store it in an environment of 4-7°C. When using, remove the plastic film, apply the muscle suspension plaster patch to the injured area or painful area, and fix it by wrapping a bandage.

[0081] The medicinal effect of the muscle-hanging plaster prepared by the present invention is studied:

[0082] 24 healthy SD rats, half male and half female, were randomly divided into 4 groups, namely, blank control group, model group, low-dose group and high-dose group, with 6 rats in each group. Except for the blank control group, the same part of the right hind thigh of mice in other groups was shaved, and then mice without damaged skin were selected, and a hollow tube with a diameter of 3cm and a height of 25cm was placed on the soft tissue of the right hind limb of the rat. Then, a blunt iron pestle weighing about 1kg was used to hit the soft tissue of the right hind limb of the rat from the free fall of the top of the hollow tube to make a non-open soft tissue injury model with obvious subcutaneous hemorrhage and swelling. The blank control group did not have non-open soft tissue injury, and the model group, low-dose group and high-dose group had non-open soft tissue injury. The model group was not treated with any drugs, and the low-dose group and high-dose group were treated with the slinging plaster obtained in Application Example 1 and the slinging plaster obtained in Application Example 3, respectively, and fixed with gauze wrapped around for one week, and each group was continuously applied for 24h, and the intervention was continued for 7 days.

[0083] After the 7-day intervention, all rats were anesthetized with 7% chloral hydrate at a dose of 0.3 mL / 100 g and fixed. The muscle tissue at the center of the right calf injury of the rat was taken and divided into two parts. One part was fixed with 4% paraformaldehyde and stored in a refrigerator at 4°C for observation of pathological morphological changes; the other part was collected in a cryopreservation tube and frozen at -80°C.

[0084] Experimental Example 1: Effects on Body Weight and Food Consumption of Rats with Traumatic Blood Stasis

[0085] The dietary intake and body weight changes of rats in each group were recorded daily. Figure 1 .

[0086] like Figure 1 As shown in A, compared with the blank control group, the body weight of rats in the model group, low-dose group and high-dose group decreased significantly from the second and third days after modeling (P<0.05 or P<0.01), indicating that the modeling was successful. At the same time, the food consumption of rats in these three groups also decreased significantly (P<0.05), which was in contrast to the blank control group (as shown in Figure 1B). In addition, compared with the model group, the food consumption of rats in the high-dose group on the 6th and 7th days was significantly increased (P<0.01), indicating that high-dose diajugating paste may have a positive effect on restoring appetite. The above results show that the diajugating paste prepared by the present invention has a significant effect on the body weight and food consumption of rats at different doses, and high-dose diajugating paste has the potential to improve appetite.

[0087] Experimental Example 2: Effects on the leg diameter of rats with traumatic blood stasis

[0088] Before and every day after model preparation, the leg diameter of the rats at the bruise mark in the middle of the right hind leg was measured, and the measurement was repeated 3 times and the average value was taken. The results are shown in Figure 2 .

[0089] Swelling is a key feature of the rat traumatic blood stasis model, and the effect of the model was quantitatively evaluated by measuring the leg diameters of the right leg (modeling leg) and the left leg (non-modeling leg). Figure 2 As shown in A and 2B, compared with the blank control group, the leg diameter of the rats in the model group, low-dose group and high-dose group increased significantly on the second day of modeling (P<0.001). After the rats were treated with the hanging plaster from the second day, the leg diameter was significantly reduced in the low-dose group and the high-dose group on the third day (P<0.05) ( Figure 2 A). In addition, after 7 days of treatment, the difference in the left and right leg diameters of rats in the low-dose group and the high-dose group gradually narrowed. Specifically, there was no significant difference in leg diameter in the low-dose group on the 6th day, while there was no significant difference in leg diameter in the high-dose group after the 5th day. This shows that the use of the slinging plaster prepared by the present invention has a significant effect on reducing leg swelling in the rat trauma blood stasis model.

[0090] Test Example 3: Histological examination of rat muscle

[0091] After the rats were killed, the damaged muscle tissue was extracted and fixed in 4% paraformaldehyde, and sent to the company for hematoxylin-eosin (HE) staining 24 hours later. The improvement effect of the slinging plaster on the pathological lesions of injured muscle tissue was determined by histopathological examination. The results are shown in Figure 3 .

[0092] exist Figure 3It was observed that the muscle tissue of the model group rats showed significant blood cell extravasation compared with the blank control group, which may be due to increased vascular permeability caused by tissue damage or inflammatory response. Further, in both the low-dose group and the high-dose group, the degree of blood cell extravasation was reduced. This indicates that the tendon-hanging plaster prepared by the present invention may have the potential to reduce inflammatory response and reduce vascular permeability. In addition, in the low-dose group and the high-dose group, the vascular structure of the muscle tissue was significantly dilated, which may be due to the regulatory effect of the drug on vasodilation function, thereby improving local blood flow and tissue perfusion. This vasodilation phenomenon may be related to the anti-inflammatory and vascular protective effects of the tendon-hanging plaster prepared by the present invention, and provides valuable clues for further studying its potential application in the treatment of related diseases.

[0093] Clinical trial cases:

[0094] (1) Case 1: A 45-year-old female patient suffered from elbow sprain. She had been treated with various methods for many years without success. After one course of treatment with the drug of the present invention, her condition improved significantly. The pain disappeared after one day and the swelling disappeared after one week. She was clinically cured.

[0095] (2) Case 2: A 70-year-old male patient suffered a leg injury with a large area of ​​hematoma and unbearable pain. After one course of treatment with the drug of the present invention, the patient showed significant improvement. The pain disappeared after 2 days, and a large area of ​​bruises appeared on the skin. The blood stasis was suspended outside the body. After 1 month, the blood stasis and swelling disappeared, and the patient was clinically cured.

[0096] (3) Case 3: A 62-year-old female patient, who had been suffering from cervical spondylosis for many years, showed significant improvement after one course of treatment with the drug of the present invention, and the pain was significantly relieved after 2 days.

[0097] The above-described embodiments provide a detailed description of the technical solutions and beneficial effects of the present invention. It should be understood that the above description is only a specific embodiment of the present invention and is not intended to limit the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected.

Claims

1. A method for preparing a muscle suspension plaster, characterized in that: The preparation method comprises the following steps: 2-5 parts by weight of Radix Angelicae Pubescentis, 2-5 parts by weight of safflower, 2-5 parts by weight of asarum, 1-3 parts by weight of galangal, 1-3 parts by weight of clove, 2-5 parts by weight of angelica, 0.3-0.8 parts by weight of raw rhubarb, 1-3 parts by weight of raw liquorice, 2-5 parts by weight of raw gardenia, 2-5 parts by weight of notopterygium wilfordii, 0.6-1.2 parts by weight of dragon's blood, 2-5 parts by weight of frankincense, 2-5 parts by weight of myrrh, 2-5 parts by weight of sappan wood, 2-5 parts by weight of charcoal, 1-3 parts by weight of gypsum, 2-5 parts by weight of angelica pubescens, 1-3 parts by weight of camphor and 3-7 parts by weight of redbud bark are mixed and ground, sieved through a sieve to form fine powder, put into a mixer for mixing to obtain mixed medicinal powder, and maltose is added to the mixed medicinal powder and stirred to obtain the tendon-hanging paste.

2. The method for preparing a muscle suspension plaster according to claim 1, characterized in that: Calculated by weight, the tendon-hanging plaster includes the following traditional Chinese medicines: 3 parts of radix polygoni lobatae, 3 parts of safflower, 3 parts of asarum, 1.5 parts of galangal, 1.5 parts of cloves, 3 parts of angelica, 0.6 parts of raw rhubarb, 1.5 parts of raw licorice, 3 parts of raw gardenia, 3 parts of notopterygium, 1 part of Sanguisorba officinalis, 3 parts of frankincense, 3 parts of myrrh, 3 parts of Sappan wood, 3 parts of Sanguisorba officinalis charcoal, 1.5 parts of gypsum, 3 parts of angelica dahurica, 1.5 parts of camphor and 5 parts of Bauhinia bark.

3. A muscle suspension plaster prepared by the method for preparing a muscle suspension plaster according to claim 1 or 2, characterized in that: The dosage form of the muscle suspension plaster includes ointment and patch.

4. The muscle suspension plaster according to claim 3, characterized in that: The method of using the muscle suspension plaster is to apply it directly to the affected area, change it every 24 hours, and apply it continuously for 1 to 3 weeks.