Application of lithium salt in preparation of animal fattening preparation

Abstract

The invention discloses an application of a lithium salt in preparation of an animal fattening preparation. Based on standardized cell and animal experiments, the inventor finds that the lithium salt has application value in preparation of animal fattening preparations. In view of the fact that lithium ions in lithium salts such as lithium carbonate and lithium chloride are positive monovalent alkali metal ions, the lithium ions are low in preparation and purchase cost, good in water solubility and absorbability and stable in chemical property, and can avoid the drug metabolism problem, especially the rumen bypass problem of ruminants, so that the lithium ions can be used in various modes such as digestive tract absorption and the like; the production performance of animals can be improved at a lower cost, so that the feed additive has a wide market application prospect.

Description

Technical Field

[0001] The invention belongs to the field of biotechnology and relates to the application of lithium salt in the preparation of an animal fattening improving preparation. Background Art

[0002] Feed is the general term for food used by humans to raise animals. Feed additives refer to a small amount of substances added during the production and use of feed, which can enhance the nutritional value of the basic feed and may have a more obvious effect on one or more aspects such as improving animal production performance, ensuring animal health, saving feed costs, and improving the quality of livestock products.

[0003] The livestock and poultry breeding industry has high requirements for the economic performance of animals, so it pays special attention to the parameter of feed-to-meat ratio. The so-called feed-to-meat ratio refers to the amount of feed consumed by livestock and poultry to gain one kilogram of weight. It is an important indicator for evaluating feed performance. Therefore, it is urgent to find feed additives that can improve the feed-to-meat ratio at a lower cost. This is one of the core issues in the development of modern livestock and poultry technology. Summary of the invention

[0004] The present application provides a feed additive for improving the meat-feed ratio by using lithium salt to improve the economic benefit of feed application in animal breeding.

[0005] The lithium salt described in the present invention refers to salts containing lithium with atomic number 3, including but not limited to lithium chloride and lithium carbonate.

[0006] The application described in the present invention refers to allowing animals to ingest lithium salts through the digestive tract to make the lithium ion concentration in the body close to the therapeutic dose, including digestive tract ingestion application methods such as feed addition, gavage and brick licking.

[0007] The animals described in the present invention specifically refer to various animals belonging to the classes Mammalia and Aves of the phylum Chordata in animal taxonomy.

[0008] In the process of using lithium salts to prevent and treat animal ketosis, the inventor unexpectedly discovered that lithium salts can significantly increase the rate of animal fattening and weight gain. Lithium is an alkali metal element, and its single substance chemical properties are relatively active. However, lithium exists in the form of lithium ions with a valence of +1 in its derivative salts. The chemical properties of this lithium ion are extremely stable and will not be decomposed by the rumen of dairy cows and animal intestinal microorganisms, nor will it be affected by the metabolism of animal livers, etc. Moreover, it is lithium ions that work in the body and cells, so what kind of lithium salt preparation is ingested is not the key to the problem, because whether it is lithium carbonate, lithium chloride or other low-toxic lithium salts, they all dissociate into lithium ions in body fluids and cells, and then improve the overall metabolic performance of animals, thereby improving the feed-to-meat ratio of feeds with added lithium salts.

[0009] Moreover, lithium carbonate is a mature drug in human clinical medicine. For example, lithium carbonate sustained-release tablets are mainly used to treat mania. They have a good treatment and relapse prevention effect on bipolar disorder with alternating mania and depression, and also have a preventive effect on recurrent depression. It is also used to treat schizoaffective psychosis. It has a long history of application and a large amount of clinical safety data. It is safe when the blood sample is measured to have a blood lithium concentration of 0.4-1.2mmol / L. From the perspective of biological evolution, humans are mammals, and mammals and birds belong to amniotes of the subphylum vertebrate of the phylum chordata, that is, they have a close relationship with each other. Therefore, these animals also have great similarities in metabolic patterns, including the metabolic process of lithium salts in the body, etc. Therefore, the data accumulation of lithium salts for the treatment of mania in human clinical medicine for many years has ensured the safety of lithium ions within a certain concentration in the body, which has important reference significance for the preparation of animal fattening agents using lithium salts in the present invention.

[0010] Specifically, Example 1 of the present invention uses a culture solution containing 0.05mmol / L of lithium carbonate to treat porcine kidney cells (PK-15)‌, and determines the cell viability, and finds that its cell viability is enhanced by 23±0.21%, confirming that lithium carbonate can promote cell proliferation. In view of this, Example 2 randomly selects 20 piglets of the same genetic background from the same batch of breeding at the age of 2 months, and randomly divides them into a control group and an experimental group of 10 pigs each. The control group is fed normally, and the experimental group maintains the same feeding conditions as the control group in other aspects, and lithium carbonate is added to the daily feed according to 5 mg / kg of pig body weight. Three months of experimental observation found that compared with the control group, the activity of the pigs in the feeding group decreased and the docility increased (only observed, not quantified), and there was no significant difference in food intake; however, the weight gain value of the feeding group increased by 7.31±2.2% compared with the control group (t-test analysis showed significant differences). The above examples show that lithium carbonate can indeed improve the cell viability of domestic pigs, increase the fattening speed of piglets, and thus improve the feed compensation ratio.

[0011] In summary, the present invention provides a method for using lithium salts as a functional feed additive for animal fattening. In view of the extremely strong stability of lithium ions and good absorption by animals, lithium salts can be used to prepare various preparations for digestive tract administration, so that the lithium ion concentration in animal cells reaches the therapeutic dose range.

[0012] Compared with the prior art, the present invention has the following beneficial effects: 1. The lithium salt used in the present invention has very stable physical and chemical properties as a whole and is inexpensive, so it is convenient and economical to store and use.

[0013] 2. The lithium salt used in the present invention has good solubility. If the drug is administered through the digestive tract, since the chemical properties of lithium ions are extremely stable, there is no possibility of metabolism into other substances in the body, and there is no rumen effect. Therefore, it can be used in a relatively cheap and convenient way such as adding it to feed and drinking water.

[0014] 3. From the experimental data, the present invention has obvious effects. See Examples 1 and 2 for details.

[0015] As described above, Examples 1 and 2 are only preferred specific embodiments of the present invention, and the protection scope of the present invention is not limited thereto. Any simple change or equivalent replacement of the technical solution that can be obviously obtained by any technician familiar with the technical field within the scope of the formula disclosed in the present invention should also be regarded as the protection scope of the present invention.

Claims

1. The use of lithium salts in the preparation of preparations for improving animal fattening, wherein the lithium salt refers to lithium chloride or lithium carbonate. The amount of lithium salt in the preparation should be based on the intake method to ensure that the lithium ion concentration in the animal is at a therapeutic dose.

2. The animal according to claim 1 refers specifically to various higher animals belonging to the class Mammalia and the class Aves of the phylum Chordata in animal taxonomy.

3. The use according to claim 1, wherein the intake method refers to the animal taking in lithium salts through the digestive tract so that the lithium ions in the cells maintain a specific molar concentration during the treatment cycle.