Multi-channel radio frequency energy ablation output system and method

Abstract

The invention discloses a multichannel radio frequency energy ablation output system and method. Comprising an MCU control circuit, a touch screen display module, a temperature detection circuit, a sound prompt circuit, a program control voltage regulation circuit, a radio frequency energy generation circuit, a channel selection circuit, an energy bearing system, an output interface and detection circuit, a cooling system control circuit, a bypass measurement circuit and a system power supply circuit. The MCU control circuit sends an instruction signal to control the program control voltage regulation circuit and the radio frequency energy generation circuit to work, so that radio frequency energy output with fixed frequency and adjustable power is obtained, and the radio frequency energy output is sorted by the channel selection circuit and then is transmitted to the output interface, and is output to a corresponding energy bearing system by the output interface; the radiofrequency ablation output method and treatment scheme with adjustable power, real-time temperature detection, a cooling system and a built-in case system are realized, the operation steps of radiofrequency ablation treatment are simplified, and the radiofrequency ablation treatment is more efficient and quicker.

Description

Technical Field

[0001] The present invention belongs to the technical field of radiofrequency ablation therapy, and in particular relates to a multi-channel radiofrequency energy ablation output system and method. Background Art

[0002] The human body is a complex structure composed of many organic and inorganic substances. Body fluids contain a large number of dielectrics, such as ions, water, and colloidal particles. The human body mainly relies on the movement of ions to conduct current. Under the action of high-frequency alternating current, the direction of ion concentration changes with the direction of the current, changing back and forth between the positive and negative half cycles. Under high-frequency oscillation, the ions between the two electrodes move rapidly along the direction of the electric lines, gradually changing from a mobile state to a vibrating state. Due to the different sizes, masses, charges, and movement speeds of various ions, the ions rub against each other and collide with other particles to produce biothermal effects. Due to the poor heat dissipation of tumors, the temperature of tumor tissue is higher than that of adjacent normal tissues. In addition, cancer cells are sensitive to high heat, and high heat can kill cancer cells without side effects. When radio frequency current flows through human tissue, the rapid change of the electromagnetic field causes the positive and negative ions in the cells to move rapidly, so the friction between them and other molecules and ions in the cells causes the temperature of the lesion to rise, causing the water inside and outside the cells to evaporate, dry, shrink and fall off, resulting in aseptic necrosis, thereby achieving the purpose of treatment.

[0003] The existing overall radiofrequency ablation treatment has complicated operation steps, cannot realize intelligent operation and intelligent adjustment, and the radiofrequency energy of radiofrequency treatment cannot be output in multiple channels, resulting in low efficiency of radiofrequency ablation treatment. Therefore, the present invention proposes a multi-channel radiofrequency energy ablation output system and method. Summary of the invention

[0004] The object of the present invention is to provide a multi-channel radiofrequency energy ablation output system and method to solve the problems raised in the above background technology.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a multi-channel radio frequency energy ablation output system, including an MCU control circuit, a touch screen display module, a temperature detection circuit, a sound prompt circuit, a programmable voltage regulation circuit, a radio frequency energy generation circuit, a channel selection circuit, an energy carrying system, an output interface and detection circuit, a cooling system control circuit, a bypass measurement circuit and a system power supply circuit;

[0006] The system power supply circuit is used to convert the 220V AC power supply into the 24V DC power supply required by the system;

[0007] The touch screen display module is electrically connected to the MCU control circuit and is responsible for the two-way interaction of the system;

[0008] The temperature detection circuit is a thermocouple detection circuit, which is electrically connected to the MCU control circuit and is used to transmit the read temperature information;

[0009] The sound prompt circuit is electrically connected to the MCU control circuit and is used to provide a sound signal when necessary;

[0010] The program-controlled voltage regulating circuit is electrically connected to the MCU control module and is used to adjust the operating voltage of the radio frequency energy generating circuit;

[0011] The radio frequency energy generating circuit is electrically connected to the MCU control module and the program-controlled voltage regulating circuit, is powered by the program-controlled voltage regulating circuit, and is provided with a corresponding frequency signal by the MCU control module;

[0012] The channel selection circuit is a relay module, whose control end is electrically connected to the MCU control module, and whose opening and closing end is electrically connected to the RF energy generation circuit, and is used to transfer the RF energy to different output interfaces;

[0013] The output interface and detection circuit are composed of an aviation plug and a resistor voltage divider circuit, which are electrically connected to the channel selection circuit and are used to transmit the generated radio frequency energy to the energy carrying system;

[0014] The energy carrying system is used to arrange a circuit at a designated lesion to output the generated radio frequency energy, eliminate the biological activity of the lesion, and achieve a therapeutic effect;

[0015] The bypass measurement circuit is a volt-ampere detection circuit composed of a current transformer and a sampling coil, which is electrically connected to the MCU control circuit and is used to detect the actual output power of the system;

[0016] The MCU control circuit is responsible for the scheduling, operation state switching, negative feedback adjustment and user interaction of the entire system;

[0017] The cooling system control circuit includes a peristaltic pump and a peristaltic pump drive module. The MCU control module sends PWM signals and level signals to the peristaltic pump drive module to control the rotation speed, direction, and start and stop of the peristaltic pump, guide the cooling liquid to flow through the energy carrying system, and cool the system.

[0018] Preferably, the touch screen display module integrates display and touch functions. Through the UI interface, the user touches to select modes, adjust power, set time, and start and stop the cooling system. It communicates with the MCU control module in two directions, and sends corresponding signals to the MCU control module when the user operates. The MCU control module will also display real-time information of the system operation on the screen in real time to inform the user; the UI interface of the touch display module also integrates a medical record storage system.

[0019] Preferably, the temperature detection circuit is composed of a thermocouple detection chip and its peripheral circuits, which communicates unidirectionally with the MCU control module and is responsible for detecting the temperature signal fed back by the energy carrying system and transmitting it to the MCU control module in real time.

[0020] Preferably, the programmable voltage regulation circuit is composed of a DAC chip, a gate drive chip, a PWM signal generating chip, a high-power field effect transistor, a transformer coil, a post-stage filtering device, and a negative feedback loop; the MCU control module communicates with the DAC chip, controls the DAC chip to output a corresponding voltage to be transmitted to the PWM signal generating chip, the PWM signal generating chip changes the duty cycle of the PWM signal according to the size of the voltage, and transmits the signal to the gate drive chip, the gate drive chip drives the high-power field effect transistor to switch and close, the field effect transistor is connected to the transformer coil, thereby transforming the 24V DC voltage input to the system to a specified voltage, and transmitting it to the RF energy generating circuit through the post-stage filtering device, the negative feedback loop is responsible for feeding back the output voltage to the previous stage PWM signal generating chip, and jointly controlling the output of the PWM signal with the voltage output by the DAC chip to avoid output voltage jumps.

[0021] Preferably, the RF energy generating circuit is composed of a multi-stage operational amplifier circuit, a gate drive chip, a high-power field effect transistor, an energy storage and filtering system, and an output coupling coil; the MCU control module sends a PWM signal of corresponding frequency, which is output to the gate drive chip after isolation through the multi-stage operational amplifier circuit; the gate drive chip controls the opening and closing of the high-power field effect transistor according to the frequency of the PWM signal, and periodically stores the electric energy output by the programmable voltage regulating circuit into the energy storage system; due to the RC configuration of the system, it can also act as a high-pass filter to filter out the influence of low-frequency clutter on the system; due to the periodic opening and closing of the high-power field effect transistor, the energy storage system will also periodically output energy to the output coupling coil, which is the RF energy generated by the circuit.

[0022] Preferably, the channel selection circuit is four octagonal relay circuits, and the MCU control circuit determines which output interface is connected to the energy carrying system based on the output interface and the detection circuit, thereby turning on the corresponding relay.

[0023] Preferably, the energy carrying system is integrated with a temperature probe, a water pipe cooling circuit, a radiofrequency ablation needle of indefinite length specifications, and a negative electrode patch integrated with a temperature probe, wherein the radiofrequency ablation needle is responsible for inserting into lesions in different parts of the patient's body, the needle head of the radiofrequency ablation needle is made of metal and is responsible for outputting radiofrequency energy, and the rest is made of non-conductive material to prevent radiofrequency energy from acting on non-lesion areas; the negative electrode patch is responsible for being applied to the surface of the body skin to form a radiofrequency energy circuit; the temperature probes on both are connected to the detection circuit of the output interface, and the temperatures of the two are fed back to the MCU control circuit in real time, which is then transmitted to the touch display module for display, and an alarm is issued when the threshold is exceeded.

[0024] Preferably, the bypass measurement circuit is composed of a sampling coil and a current transformer, a multi-stage operational amplifier circuit and an ADC sampling chip. While the output circuit is outputting, the sampling coil and the current transformer will sample the output current and voltage, which will be adjusted by the operational amplifier and sent to the ADC circuit for analog-to-digital conversion and then transmitted to the MCU control unit. The MCU control unit will calculate the actual power and display it on the touch display module.

[0025] A multi-channel radiofrequency energy ablation output method adopts the system, and the specific steps include: S1: the system is powered by 220V AC, and the MCU control module first detects whether each module is correctly connected and works normally, and then enters the standby state;

[0026] S2: The user operates the display touch module to operate the case system, set the power and the working time of the system. After that, if the user presses the output button, the system will open the corresponding relay through the channel selection circuit according to the access status of the energy carrying system. At the same time, the cooling system control circuit controls the peristaltic pump to rotate and guide the coolant to cool the energy carrying system;

[0027] S3: After that, the MCU control module controls the output voltage of the programmable voltage regulating circuit, and the voltage corresponds to the output power set by the user;

[0028] S4: The voltage is transmitted to the RF energy generation circuit, and the RF energy generation circuit generates a RF signal with a fixed frequency in coordination with the PWM frequency signal transmitted by the MCU, and transmits the signal to the connected energy carrier system through the turned-on relay;

[0029] S5: At the same time, the detection circuit on the output interface will detect the temperature of the load-bearing system in real time, the bypass measurement circuit will measure the real-time output current and voltage, and the MCU will calculate the real-time power for display;

[0030] S6: The MCU stops outputting after the set working time is reached, and then returns to the standby state, waiting for the next operation of the user.

[0031] Preferably, the power adjustment method is: MCU controls the programmable voltage regulation circuit to generate different voltages, which are applied to the energy carrying system through the radio frequency energy output circuit and the channel selection circuit. The energy carrying system will release the energy in a concentrated manner at the lesion, thereby achieving the effect of eliminating the biological activity of cells at the lesion: The power can be calculated by the following formula:

[0032] First of all, the RF energy output is essentially an AC output. If the AC current is set to I and the AC voltage is set to u, the expression is as follows:

[0033] i=Icos(ωt)

[0034] u=Ucos(ωt+θ)

[0035] Where I is the amplitude of the current, U is the amplitude of the voltage, ω is the angular frequency, t is the time, and θ is the voltage leading phase angle;

[0036] The calculation formula of AC instantaneous power is:

[0037]

[0038] The instantaneous power consists of two parts. The second part is the double frequency AC power, which is zero on average in one cycle and is reactive power. Therefore, the power output by the RF is the AC active power, and its calculation formula is:

[0039] Preferably, the RF energy generation circuit sends a fixed-frequency PWM signal through the MCU control module, and controls the high-power field effect tube to open and close according to the frequency of the PWM signal through the gate drive chip. The RLC circuit of the subsequent stage will store energy when the first field effect tube is turned on, and the second field effect tube is in a closed state. When the second field effect tube is turned on and the first field effect tube is switched to a closed state, the RLC circuit of the subsequent stage releases energy to the output coupling coil, and the RLC circuit stores negative energy at the same time. When the second field effect tube is turned off and the first field effect tube is turned on, a part of the RLC circuit stores positive energy and a part releases negative energy, thereby forming a complete sinusoidal RF energy output; wherein, the current flowing through the capacitor after the switch is closed is:

[0040]

[0041] In the above, I is current, C is capacitance, t is time, and Uc is capacitor voltage. According to Kirchhoff's law, we have:

[0042]

[0043] The above Uin is the input signal, R is the series resistance, Uc is the capacitor voltage, and C is the capacitor capacity.

[0044] Arranged to get formula 1-1:

[0045]

[0046] The above equation is a first-order linear differential equation and is non-homogeneous;

[0047] First convert the above equation into a homogeneous equation, and get equation 1-2:

[0048]

[0049] After separating the variables we get:

[0050]

[0051] Integrate both ends:

[0052]

[0053] The solution is:

[0054]

[0055] It can also be written as:

[0056]

[0057] make

[0058] K=±e K1

[0059] The general solution of equation 1-2 is obtained:

[0060]

[0061] Then continue to solve the equation using the constant variation method. First, replace K with the unknown function u(t) of t to obtain equation 1-3:

[0062]

[0063] Taking the derivative of both sides with respect to time t, we get equation 1-4:

[0064]

[0065] Substituting equation 1-3 and equation 1-4 into equation 1-1, we get:

[0066]

[0067] Rearranging the above formula gives:

[0068]

[0069] Integrate both sides to get

[0070]

[0071] Substituting the above formula into formula 1-3, we get:

[0072]

[0073] That is, we get formula 1-5:

[0074]

[0075] Substitute the initial conditions: When charging, when t = 0, uc = 0, substitute the above formula and solve A = -Uin

[0076] Substituting A into equation 1-5, we get:

[0077]

[0078] Therefore, the charging time of the capacitor can be calculated by the above formula:

[0079] The subsequent derivation steps will not be described in detail in the present invention. After derivation, the discharge time of the capacitor can be calculated by the formula:

[0080]

[0081] The above Uin is the input signal, R is the series resistance, Uc is the capacitor voltage, C is the capacitor capacity, and t is the time;

[0082] The charging equation for the inductor is:

[0083]

[0084] The above Uin is the input power supply, R is the series resistance, I is the current, L is the inductance, and t is the time;

[0085] The discharge equation of the inductor is:

[0086]

[0087] The above Uin is the input power supply, R is the series resistance, I f is the initial current, L is the inductance, and t is the time;

[0088] After calculation by the above equation, the specific capacitance value, resistance value and inductance value in the final selected circuit ensure that the capacitor charging time is less than the inverse of the PWM signal output by the MCU control module, and the inductance discharge time also needs to be less than this value.

[0089] Compared with the prior art, the present invention has the following beneficial effects:

[0090] The system of the present invention realizes adjustable and high-power output of radio frequency energy through a programmable voltage regulating circuit and a radio frequency energy output circuit, thereby meeting the power requirement of radio frequency treatment, and the radio frequency ablation energy is a continuous sinusoidal wave output without a DC component, which will not harm the human body; the system adopts multi-channel output, and each channel is equipped with a detection circuit, which can intelligently detect which channel is connected to the energy carrying system without manual setting; the system is provided with power detection and temperature detection circuits, and when the radio frequency output and temperature are abnormal, the control module will automatically stop the radio frequency energy output to ensure that the patient will not be harmed; the system has a built-in cooling system control circuit, which can realize the linkage between the cooling system and the radio frequency ablation operation; the system has its own medical record recording system, which will record the operation start date, radio frequency ablation power, and radio frequency ablation duration while performing radio frequency ablation, so as to facilitate users to organize medical records and match patients. BRIEF DESCRIPTION OF THE DRAWINGS

[0091] Figure 1 Schematic diagram of the circuit structure of the system of the present invention;

[0092] Figure 2 This is a schematic diagram of a program-controlled voltage regulation circuit module of the present invention;

[0093] Figure 3 This is a schematic diagram of a radio frequency energy generation circuit module of the present invention;

[0094] Figure 4 The schematic diagram of the program-controlled voltage regulation circuit design of the present invention;

[0095] Figure 5 The schematic diagram of the radio frequency energy generation circuit design of the present invention;

[0096] Figure 6 The schematic diagram of the channel selection circuit design of the present invention;

[0097] Figure 7 The schematic diagram of the bypass measurement circuit design of the present invention;

[0098] Figure 8 The output interface, detection circuit and temperature detection circuit design schematic diagram of the present invention;

[0099] Fig. 9 It is the schematic diagram of the MCU control circuit design of the present invention;

[0100] Fig.10 This is a schematic diagram of the radio frequency energy output equivalent circuit of the present invention;

[0101] Fig.11 It is a schematic diagram of the process of the present invention; DETAILED DESCRIPTION

[0102] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0103] Example 1

[0104] See also Figure 1 and Fig.11 , the present invention provides a technical solution: a multi-channel radio frequency energy ablation output system, including an MCU control circuit, a touch screen display module, a temperature detection circuit, a sound prompt circuit, a programmable voltage regulation circuit, a radio frequency energy generation circuit, a channel selection circuit, an energy carrying system, an output interface and detection circuit, a cooling system control circuit, a bypass measurement circuit and a system power supply circuit;

[0105] The system power supply circuit uses the ARCH brand AC-DC module to convert the 220V AC power supply into the 24V DC power supply required by the system;

[0106] The touch screen display module is electrically connected to the MCU control circuit and is responsible for the two-way interaction of the system;

[0107] The temperature detection circuit is a thermocouple detection circuit, which is electrically connected to the MCU control circuit and is used to transmit the read temperature information;

[0108] The sound prompt circuit is electrically connected to the MCU control circuit and is used to provide a sound signal when necessary;

[0109] A programmable voltage regulating circuit, which is electrically connected to the MCU control module and is used to adjust the operating voltage of the radio frequency energy generating circuit;

[0110] A radio frequency energy generating circuit is electrically connected to the MCU control module and the program-controlled voltage regulating circuit, is powered by the program-controlled voltage regulating circuit, and is provided with a corresponding frequency signal by the MCU control module;

[0111] The channel selection circuit is a relay module, whose control end is electrically connected to the MCU control module, and whose opening and closing end is electrically connected to the RF energy generation circuit, and is used to transfer the RF energy to different output interfaces;

[0112] The output interface and detection circuit are composed of an aviation plug and a resistor voltage divider circuit, which are electrically connected to the channel selection circuit and are used to transmit the generated radio frequency energy to the energy carrying system;

[0113] The energy carrying system is used to arrange a circuit at the designated lesion to output the generated radio frequency energy, eliminate the biological activity of the lesion, and achieve the treatment effect;

[0114] The bypass measurement circuit is a volt-ampere detection circuit composed of a current transformer and a sampling coil, which is electrically connected to the MCU control circuit and is used to detect the actual output power of the system;

[0115] The MCU control circuit is the STM32 microcontroller and its peripheral circuits, which are responsible for the scheduling, operation state switching, negative feedback adjustment and user interaction of the entire system;

[0116] The cooling system control circuit includes a peristaltic pump and a peristaltic pump driver module. The MCU control module sends PWM signals and level signals to the peristaltic pump driver module to control the rotation speed, direction, and start and stop of the peristaltic pump, and guide the cooling liquid to flow through the energy-carrying system to cool the system. The cooling system is automatically turned on when the radio frequency energy starts to output, and is automatically turned off when the radio frequency energy stops output. Intelligent operations such as these simplify the machine's operating procedures and allow users to focus more on treatment.

[0117] In this embodiment, preferably, the touch screen display module integrates display and touch functions. Through the UI interface, the user touches to select modes, adjust power, set time, and start and stop the cooling system. It communicates with the MCU control module in two directions. When the user operates, the corresponding signal is sent to the MCU control module. The MCU control module will also display the real-time information of the system operation on the screen to inform the user. The UI interface of the touch display module also integrates a medical record storage system. The user can edit patient information, and the machine will record the power and time during each ablation to facilitate detailed records of the subsequent treatment.

[0118] In this embodiment, preferably, the temperature detection circuit is composed of a thermocouple detection chip and its peripheral circuits. The circuit communicates with the MCU control module in a one-way manner, is responsible for detecting the temperature signal fed back by the energy carrying system, and transmits it to the MCU control module in real time.

[0119] In this embodiment, preferably, the program-controlled voltage regulation circuit is composed of a DAC chip, a gate drive chip, a PWM signal generation chip, a high-power field effect tube, a transformer coil, a post-stage filter device, and a negative feedback loop; the connection between the above modules is shown in the attached Figure 2, its operation steps are as follows: the MCU control module communicates with the DAC chip, controls the DAC chip to output the corresponding voltage to the PWM signal generating chip, the PWM signal generating chip changes the duty cycle of the PWM signal according to the size of the voltage, and transmits the signal to the gate driving chip, the gate driving chip drives the high-power field effect tube to switch and close, the field effect tube is connected to the transformer coil, so as to transform the 24V DC voltage input by the system to the specified voltage, and transmit it to the RF energy generating circuit through the post-filter device, the negative feedback loop is responsible for feeding back the output voltage to the previous stage PWM signal generating chip, and jointly controls the output of the PWM signal with the voltage output by the DAC chip to avoid output voltage jumps.

[0120] In this embodiment, preferably, the RF energy generation circuit is composed of a multi-stage operational amplifier circuit, a gate drive chip, a high-power field effect transistor, an energy storage and filtering system, and an output coupling coil; the connection between the above modules is shown in the attached Figure 3 The operation steps are as follows: the MCU control module sends a PWM signal of the corresponding frequency, which is isolated by a multi-stage operational amplifier circuit and then output to the gate drive chip. The gate drive chip controls the opening and closing of the high-power field effect tube according to the frequency of the PWM signal, and periodically stores the electric energy output by the programmable voltage regulation circuit into the energy storage system. Due to the RC configuration of the system, it can also play the role of a high-pass filter to filter out the influence of low-frequency clutter on the system. Due to the periodic opening and closing of the high-power field effect tube, the energy storage system will also periodically output energy to the output coupling coil, which is the RF energy generated by the circuit.

[0121] In this embodiment, preferably, the channel selection circuit is four octagonal relay circuits, and the MCU control circuit determines which output interface is connected to the energy carrying system based on the output interface and the detection circuit, thereby turning on the corresponding relay.

[0122] In this embodiment, preferably, the energy carrying system is integrated with a temperature probe, a water pipe cooling circuit, a radiofrequency ablation needle of indefinite length specifications, and a negative electrode patch integrated with a temperature probe, wherein the radiofrequency ablation needle is responsible for inserting into lesions in different parts of the patient's body, the needle head of the radiofrequency ablation needle is made of metal, which is responsible for outputting radiofrequency energy, and the rest is made of non-conductive material to prevent radiofrequency energy from acting in non-lesion areas; the negative electrode patch is responsible for being applied to the surface of the body skin to form a radiofrequency energy circuit; the temperature probes on both are connected to the detection circuit of the output interface, and the temperatures of the two are fed back to the MCU control circuit in real time, which is then transmitted to the touch display module for display, and an alarm is issued when the threshold is exceeded.

[0123] In this embodiment, preferably, the bypass measurement circuit is composed of a sampling coil and a current transformer, a multi-stage operational amplifier circuit and an ADC sampling chip. While the output circuit is outputting, the sampling coil and the current transformer will sample the output current and voltage, which will be adjusted by the operational amplifier and sent to the ADC circuit for analog-to-digital conversion and then transmitted to the MCU control unit. The MCU control unit will calculate the actual power and display it on the touch display module.

[0124] A multi-channel radiofrequency energy ablation output method adopts the system, and the specific steps include: S1: the system is powered by 220V AC, and the MCU control module first detects whether each module is correctly connected and works normally, and then enters the standby state;

[0125] S2: The user operates the display touch module to operate the case system, set the power and the working time of the system. After that, if the user presses the output button, the system will open the corresponding relay through the channel selection circuit according to the access status of the energy carrying system. At the same time, the cooling system control circuit controls the peristaltic pump to rotate and guide the coolant to cool the energy carrying system;

[0126] S3: After that, the MCU control module controls the output voltage of the programmable voltage regulating circuit, and the voltage corresponds to the output power set by the user;

[0127] S4: The voltage is transmitted to the RF energy generation circuit, and the RF energy generation circuit generates a RF signal with a fixed frequency in coordination with the PWM frequency signal transmitted by the MCU, and transmits the signal to the connected energy carrier system through the turned-on relay;

[0128] S5: At the same time, the detection circuit on the output interface will detect the temperature of the load-bearing system in real time, the bypass measurement circuit will measure the real-time output current and voltage, and the MCU will calculate the real-time power for display;

[0129] S6: The MCU stops outputting after the set working time is reached, and then returns to the standby state, waiting for the next operation of the user.

[0130] In this embodiment, preferably, the power adjustment method is: MCU controls the programmable voltage regulating circuit to generate different voltages, which are applied to the energy carrying system through the radio frequency energy output circuit and the channel selection circuit. The energy carrying system will release the energy in a concentrated manner at the lesion, thereby achieving the effect of eliminating the biological activity of cells at the lesion: The power can be calculated by the following formula:

[0131] First of all, the RF energy output is essentially an AC output. If the AC current is set to I and the AC voltage is set to u, the expression is as follows:

[0132] i=Icos(ωt)

[0133] u=Ucos(ωt+θ)

[0134] Where I is the amplitude of the current, U is the amplitude of the voltage, ω is the angular frequency, t is the time, and θ is the voltage leading phase angle;

[0135] The calculation formula of AC instantaneous power is:

[0136]

[0137] The instantaneous power consists of two parts. The second part is the double frequency AC power, which is zero on average in one cycle and is reactive power. Therefore, the power output by the RF is the AC active power, and its calculation formula is:

[0138] In this embodiment, preferably, as shown in the attached Figure 5 And attached Fig.10 As shown, the RF energy generation circuit sends a fixed-frequency PWM signal through the MCU control module, and controls the high-power field effect tube to open and close according to the frequency of the PWM signal through the gate drive chip. The RLC circuit of the subsequent stage will store energy when the first field effect tube is turned on. At this time, the second field effect tube is in a closed state. When the second field effect tube is turned on and the first field effect tube is switched to a closed state, the RLC circuit of the subsequent stage releases energy to the output coupling coil, and the RLC circuit stores negative energy at the same time. When the second field effect tube is turned off and the first field effect tube is turned on, part of the RLC circuit stores positive energy and part releases negative energy, thereby forming a complete sinusoidal RF energy output; wherein, the current flowing through the capacitor after the switch is closed is:

[0139]

[0140] In the above, I is current, C is capacitance, t is time, and Uc is capacitor voltage. According to Kirchhoff's law, we have:

[0141]

[0142] The above Uin is the input signal, R is the series resistance, Uc is the capacitor voltage, and C is the capacitor capacity.

[0143] Arranged to get formula 1-1:

[0144]

[0145] The above equation is a first-order linear differential equation and is non-homogeneous;

[0146] First convert the above equation into a homogeneous equation, and get equation 1-2:

[0147]

[0148] After separating the variables we get:

[0149]

[0150] Integrate both ends:

[0151]

[0152] The solution is:

[0153]

[0154] It can also be written as:

[0155]

[0156] make

[0157]

[0158] The general solution of equation 1-2 is obtained:

[0159]

[0160] Then continue to solve the equation using the constant variation method. First, replace K with the unknown function u(t) of t to obtain equation 1-3:

[0161]

[0162] Taking the derivative of both sides with respect to time t, we get equation 1-4:

[0163]

[0164] Substituting equation 1-3 and equation 1-4 into equation 1-1, we get:

[0165]

[0166] Rearranging the above formula gives:

[0167]

[0168] Integrate both sides to get

[0169]

[0170] Substituting the above formula into formula 1-3, we get:

[0171]

[0172] That is, we get formula 1-5:

[0173]

[0174] Substitute the initial conditions: When charging, when t = 0, uc = 0, substitute the above formula and solve A = -Uin

[0175] Substituting A into equation 1-5, we get:

[0176]

[0177] Therefore, the charging time of the capacitor can be calculated by the above formula:

[0178] The subsequent derivation steps will not be described in detail in the present invention. After derivation, the discharge time of the capacitor can be calculated by the formula:

[0179]

[0180] The above Uin is the input signal, R is the series resistance, Uc is the capacitor voltage, C is the capacitor capacity, and t is the time;

[0181] The charging equation for the inductor is:

[0182]

[0183] The above Uin is the input power supply, R is the series resistance, I is the current, L is the inductance, and t is the time;

[0184] The discharge equation of the inductor is:

[0185]

[0186] The above Uin is the input power supply, R is the series resistance, I f is the initial current, L is the inductance, and t is the time;

[0187] After calculation by the above equation, the specific capacitance value, resistance value and inductance value in the final selected circuit ensure that the capacitor charging time is less than the inverse of the PWM signal output by the MCU control module, and the inductor discharge time also needs to be less than this value; otherwise, it will cause the waveform to be discontinuous or excess energy to accumulate in the RF generating circuit, affecting the continuous operation and safety of the system.

[0188] Although the embodiments of the present invention have been shown and described, as detailed above, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A multi-channel radiofrequency energy ablation output system, characterized in that: It includes MCU control circuit, touch screen display module, temperature detection circuit, sound prompt circuit, programmable voltage regulation circuit, radio frequency energy generation circuit, channel selection circuit, energy carrying system, output interface and detection circuit, cooling system control circuit, bypass measurement circuit and system power supply circuit; The system power supply circuit is used to convert the 220V AC power supply into the 24V DC power supply required by the system; The touch screen display module is electrically connected to the MCU control circuit and is responsible for the two-way interaction of the system; The temperature detection circuit is a thermocouple detection circuit, which is electrically connected to the MCU control circuit and is used to transmit the read temperature information; The sound prompt circuit is electrically connected to the MCU control circuit and is used to provide a sound signal when necessary; The program-controlled voltage regulating circuit is electrically connected to the MCU control module and is used to adjust the operating voltage of the radio frequency energy generating circuit; The radio frequency energy generating circuit is electrically connected to the MCU control module and the program-controlled voltage regulating circuit, is powered by the program-controlled voltage regulating circuit, and is provided with a corresponding frequency signal by the MCU control module; The channel selection circuit is a relay module, whose control end is electrically connected to the MCU control module, and whose opening and closing end is electrically connected to the radio frequency energy generation circuit, and is used to transfer the radio frequency energy to different output interfaces; The output interface and detection circuit are composed of an aviation plug and a resistor voltage divider circuit, which are electrically connected to the channel selection circuit and are used to transmit the generated radio frequency energy to the energy carrying system; The energy carrying system is used to arrange a circuit at a designated lesion to output the generated radio frequency energy, eliminate the biological activity of the lesion, and achieve a therapeutic effect; The bypass measurement circuit is a volt-ampere detection circuit composed of a current transformer and a sampling coil, which is electrically connected to the MCU control circuit and is used to detect the actual output power of the system; The MCU control circuit is responsible for the scheduling, operation state switching, negative feedback adjustment and user interaction of the entire system; The cooling system control circuit includes a peristaltic pump and a peristaltic pump drive module. The MCU control module sends PWM signals and level signals to the peristaltic pump drive module to control the rotation speed, direction, and start and stop of the peristaltic pump, guide the cooling liquid to flow through the energy carrying system, and cool the system.

2. A multi-channel radiofrequency energy ablation output system according to claim 1, characterized in that: The touch screen display module integrates display and touch functions. Through the UI interface, the user touches to select modes, adjust power, set time, and start and stop the cooling system. It communicates with the MCU control module in two directions. When the user operates, the corresponding signal is sent to the MCU control module. The MCU control module will also display the real-time information of the system operation on the screen in real time to inform the user; the UI interface of the touch display module also integrates a medical record storage system.

3. A multi-channel radiofrequency energy ablation output system according to claim 1, characterized in that: The temperature detection circuit is composed of a thermocouple detection chip and its peripheral circuits. The circuit communicates with the MCU control module in a one-way manner and is responsible for detecting the temperature signal fed back by the energy carrying system and transmitting it to the MCU control module in real time.

4. A multi-channel radiofrequency energy ablation output system according to claim 1, characterized in that: The program-controlled voltage regulation circuit is composed of a DAC chip, a gate drive chip, a PWM signal generating chip, a high-power field effect tube, a transformer coil, a post-stage filtering device, and a negative feedback loop; the MCU control module communicates with the DAC chip, controls the DAC chip to output a corresponding voltage and transmits it to the PWM signal generating chip, the PWM signal generating chip changes the duty cycle of the PWM signal according to the size of the voltage, and transmits the signal to the gate drive chip, the gate drive chip drives the high-power field effect tube to switch and close, the field effect tube is connected to the transformer coil, so as to transform the 24V DC voltage input by the system to a specified voltage, and transmit it to the radio frequency energy generation circuit through the post-stage filtering device, the negative feedback loop is responsible for feeding back the output voltage to the previous stage PWM signal generating chip, and jointly controls the output of the PWM signal with the voltage output by the DAC chip to avoid output voltage jumps.

5. The multi-channel radiofrequency energy ablation output system according to claim 1, characterized in that: The radio frequency energy generation circuit is composed of a multi-stage operational amplifier circuit, a gate drive chip, a high-power field effect transistor, an energy storage and filtering system, and an output coupling coil; the MCU control module sends a PWM signal of corresponding frequency, which is output to the gate drive chip after isolation by the multi-stage operational amplifier circuit; the gate drive chip controls the opening and closing of the high-power field effect transistor according to the frequency of the PWM signal, and periodically stores the electric energy output by the programmable voltage regulation circuit into the energy storage system; due to the RC configuration of the system, it can also play the role of a high-pass filter to filter out the influence of low-frequency clutter on the system; due to the periodic opening and closing of the high-power field effect transistor, the energy storage system will also periodically output energy to the output coupling coil, which is the radio frequency energy generated by the circuit.

6. A multi-channel radiofrequency energy ablation output system according to claim 1, characterized in that: The channel selection circuit is composed of four octagonal relay circuits. The MCU control circuit determines which output interface is connected to the energy carrying system based on the output interface and the detection circuit, thereby turning on the corresponding relay.

7. A multi-channel radiofrequency energy ablation output system according to claim 1, characterized in that: The energy carrying system is integrated with a temperature probe, a water pipe cooling circuit, a radiofrequency ablation needle of indefinite length, and a negative electrode patch integrated with a temperature probe, wherein the radiofrequency ablation needle is responsible for inserting into lesions in different parts of the patient's body, the needle head of the radiofrequency ablation needle is made of metal and is responsible for outputting radiofrequency energy, and the rest is made of non-conductive material to prevent radiofrequency energy from acting on non-lesion areas; the negative electrode patch is responsible for being applied to the surface of the body's skin to form a radiofrequency energy circuit; the temperature probes on both are connected to the detection circuit of the output interface, and the temperatures of the two are fed back to the MCU control circuit in real time, which is then transmitted to the touch display module for display, and an alarm is issued when the threshold is exceeded.

8. The multi-channel radiofrequency energy ablation output system according to claim 1, characterized in that: The bypass measurement circuit is composed of a sampling coil and a current transformer, a multi-stage operational amplifier circuit and an ADC sampling chip. When the output circuit is outputting, the sampling coil and the current transformer will sample the output current and voltage. After adjustment by the operational amplifier, the samples are sent to the ADC circuit for analog-to-digital conversion and then transmitted to the MCU control unit. The MCU control unit calculates the actual power and displays it on the touch display module.

9. A multi-channel radiofrequency energy ablation output method, characterized in that: The system according to any one of claims 1 to 8 is used, and the specific steps include: S1: the system is powered by 220V AC, and the MCU control module first detects whether each module is correctly connected and works normally, and then enters a standby state; S2: The user operates the display touch module to operate the case system, set the power and the working time of the system. After that, if the user presses the output button, the system will open the corresponding relay through the channel selection circuit according to the access status of the energy carrying system. At the same time, the cooling system control circuit controls the peristaltic pump to rotate and guide the coolant to cool the energy carrying system; S3: After that, the MCU control module controls the output voltage of the programmable voltage regulating circuit, and the voltage corresponds to the output power set by the user; S4: The voltage is transmitted to the RF energy generation circuit, and the RF energy generation circuit generates a RF signal with a fixed frequency in coordination with the PWM frequency signal transmitted by the MCU, and transmits the signal to the connected energy carrier system through the turned-on relay; S5: At the same time, the detection circuit on the output interface will detect the temperature of the load-bearing system in real time, the bypass measurement circuit will measure the real-time output current and voltage, and the MCU will calculate the real-time power for display; S6: The MCU stops outputting after the set working time is reached, and then returns to the standby state, waiting for the next operation of the user.

10. A multi-channel radiofrequency energy ablation output method according to claim 9, characterized in that: The power adjustment method is: MCU controls the programmable voltage regulation circuit to generate different voltages, which are applied to the energy carrying system through the radio frequency energy output circuit and the channel selection circuit. The energy carrying system will release the energy in a concentrated manner at the lesion, thereby achieving the effect of eliminating the biological activity of cells at the lesion: The power can be calculated by the following formula: First of all, the RF energy output is essentially an AC output. If the AC current is set to I and the AC voltage is set to u, the expression is as follows: i=Icos(ωt) u=Ucos(ωt+θ) Where I is the amplitude of the current, U is the amplitude of the voltage, ω is the angular frequency, t is the time, and θ is the voltage leading phase angle; The calculation formula of AC instantaneous power is: The instantaneous power consists of two parts. The second part is the double frequency AC power, which is zero on average in one cycle and is reactive power. Therefore, the power output by the RF is the AC active power, and its calculation formula is: The RF energy generation circuit sends a fixed-frequency PWM signal through the MCU control module, and controls the high-power field effect tube to open and close according to the frequency of the PWM signal through the gate drive chip. The RLC circuit of the subsequent stage will store energy when the first field effect tube is turned on. At this time, the second field effect tube is in a closed state. When the second field effect tube is turned on and the first field effect tube is switched to a closed state, the RLC circuit of the subsequent stage releases energy to the output coupling coil. At the same time, the RLC circuit stores negative energy. When the second field effect tube is turned off and the first field effect tube is turned on, part of the RLC circuit stores positive energy and part releases negative energy, thereby forming a complete sinusoidal RF energy output; wherein, the current flowing through the capacitor after the switch is closed is: In the above, I is current, C is capacitance, t is time, and Uc is capacitor voltage. According to Kirchhoff's law, we have: The above Uin is the input signal, R is the series resistance, Uc is the capacitor voltage, and C is the capacitor capacity. Arranged to get formula 1-1: The above equation is a first-order linear differential equation and is non-homogeneous; First convert the above equation into a homogeneous equation, and get equation 1-2: After separating the variables we get: Integrate both ends: The solution is: It can also be written as: make K=±e K1 The general solution of equation 1-2 is obtained: Then continue to solve the equation using the constant variation method. First, replace K with the unknown function u(t) of t to obtain equation 1-3: Taking the derivative of both sides with respect to time t, we get equation 1-4: Substituting equation 1-3 and equation 1-4 into equation 1-1, we get: Rearranging the above formula gives: Integrate both sides to get Substituting the above formula into formula 1-3, we get: That is, we get formula 1-5: Substitute the initial conditions: When charging, when t = 0, uc = 0, substitute the above formula and solve A = -Uin Substituting A into equation 1-5, we get: Therefore, the charging time of the capacitor can be calculated by the above formula: The subsequent derivation steps will not be described in detail in the present invention. After derivation, the discharge time of the capacitor can be calculated by the formula: The above Uin is the input signal, R is the series resistance, Uc is the capacitor voltage, C is the capacitor capacity, and t is the time; The charging equation for the inductor is: The above Uin is the input power supply, R is the series resistance, I is the current, L is the inductance, and t is the time; The discharge equation of the inductor is: The above Uin is the input power supply, R is the series resistance, I f is the initial current, L is the inductance, and t is the time; After calculation by the above equation, the specific capacitance value, resistance value and inductance value in the final selected circuit ensure that the capacitor charging time is less than the inverse of the PWM signal output by the MCU control module, and the inductance discharge time also needs to be less than this value.

Images