Jaw defect negative pressure restoration with flushing function and capable of reserving periosteum

Abstract

A periosteum-remaining jaw defect negative pressure restoration with a flushing function comprises a base body, the base body is of a titanium alloy net structure formed through 3D printing, the two ends of the base body can be matched with bone fracture ends in an attached mode, the outer surface of the base body can be matched with a jaw periosteum in a contact mode, a through negative pressure suction pipeline is arranged in the base body, and the negative pressure suction pipeline is communicated with the negative pressure suction pipeline. The outer side pipe opening can be connected with a negative pressure aspirator, through holes formed by the titanium alloy net-shaped structure are distributed in the pipe wall of the negative pressure aspiration pipeline, a reserved flushing pipeline surrounds the periphery of the negative pressure aspiration pipeline, and flushing holes are distributed in the periphery of the reserved flushing pipeline. The restoration has the following functions of promoting the growth and differentiation of osteoblasts on the bone broken end and the periosteum surface, and promoting the formation of new bones; tissue exudate and the like can be discharged out of a body.

Description

Technical Field

[0001] The invention belongs to the clinical field of oral and maxillofacial surgery, and specifically relates to a drainage restoration for jaw bone defects. Background Art

[0002] Jaw defects caused by trauma, tumors, infections and other factors not only affect the patient's normal physiological functions, but also cause facial deformities, affect the patient's chewing, swallowing, speech and other functions, and have a serious impact on the patient's mental health. The repair and reconstruction of jaw defects has long been a major challenge facing clinical practice. At present, although methods such as autologous bone transplantation, allogeneic bone transplantation, distraction osteogenesis, and artificial replacement material repair have been used in clinical practice, their application is still greatly restricted due to problems such as complex surgery, limited material sources, and rejection reactions.

[0003] At present, there are studies on negative pressure drainage in clinical treatment. The principle of negative pressure drainage is that negative pressure can accelerate the transformation of highly proliferative epithelium and the bone remodeling of the capsule-bone interface to the cavity, thereby greatly shortening the course of treatment. The negative pressure environment is isolated from the oral bacterial environment, greatly reducing the chance of infection. However, in clinical applications, the repair of jaw defects requires the use of a negative pressure suction device to drain the surgical area. Currently, there is no jaw implant or jaw prosthesis that can be directly connected to negative pressure drainage. Summary of the invention

[0004] In order to solve the above technical problems, the present invention provides a periosteum-retaining mandibular defect negative pressure prosthesis with a flushing function.

[0005] The technical solution of the present invention is as follows:

[0006] A periosteum-retaining negative pressure prosthesis for jaw bone defects with a flushing function, characterized in that it includes a base, the base is a titanium alloy mesh structure formed by 3D printing, the two ends of the base can fit snugly with the bone ends, the outer surface can contact and fit with the jaw periosteum, the interior of the base is provided with a penetrating negative pressure suction pipe, the outer pipe opening can be connected to a negative pressure suction device, and the tube wall of the negative pressure suction pipe is distributed with through holes formed by the titanium alloy mesh structure.

[0007] Preferably, the diameter of the negative pressure suction pipe is 10-20 mm.

[0008] Further preferably, the diameter of the negative pressure suction pipe is 15 mm.

[0009] Preferably, a reserved flushing pipeline is arranged around the outer periphery of the negative pressure suction pipeline, and flushing holes are distributed on the outer periphery of the reserved flushing pipeline.

[0010] Preferably, the average diameter of the through holes is 1 mm, and the density is 3-6 per cm 2 .

[0011] Preferably, the pressure value of the applied negative pressure is 125-450 mmHg.

[0012] Preferably, intermittent negative pressure suction is performed for 15-30 minutes / hour.

[0013] Preferably, the reticular structure is a trabecular bone-like structure.

[0014] The beneficial effects of the present invention are as follows:

[0015] In recent years, additive manufacturing technology has gradually emerged in the field of bone defect repair and has become a popular research and application direction. Compared with traditional subtractive manufacturing technology, additive manufacturing has unique advantages. It can not only produce a restoration that perfectly matches the shape of the mandible, but also accurately control the internal structure of the restoration, thereby preparing a restoration that not only meets the morphological requirements but also promotes bone function repair.

[0016] The present invention uses additive technology to obtain a prosthesis matrix that conforms to the shape of the jawbone loss through 3D printing technology, and designs two prostheses that can be used in conjunction with a negative pressure suction device for negative pressure assisted treatment based on whether there is periosteum.

[0017] Specifically, the present invention is aimed at the situation where the degree of mandibular defect is that the periosteum still exists. The titanium alloy prosthesis is manufactured by 3D printing. The two ends of the prosthesis are closely fitted with the bone ends. The outer surface is porous and in contact with the mandibular periosteum. The inside is a grid structure imitating bone trabeculae. The inside is a negative pressure suction pipe that runs through the entire prosthesis, which can perform intermittent negative pressure suction. Due to the presence of the periosteum, the prosthesis is not made into a closed environment. The negative pressure suction pipe penetrates the entire prosthesis, which can promote the osteoblasts of the periosteum and the bone ends of the prosthesis to accelerate growth and differentiation under the negative pressure environment, and promote the rapid osteogenic repair of the prosthesis from the outside to the inside in multiple directions.

[0018] The above restorations have the following functions:

[0019] 1. Promote the growth and differentiation of osteoblasts on the bone ends and periosteum surface, and promote new bone formation;

[0020] 2. It can discharge tissue exudate and other substances from the body;

[0021] 3. The reserved flushing channel can also be used for flushing with saline when necessary to reduce the risk of infection in the surgical area.

[0022] Experiments have shown that low-intensity intermittent negative pressure in vitro can successfully induce MSCs to grow and differentiate into osteoblasts. In addition, the main reason for bone resorption in jaw cysts is that the cyst wall tissue secretes cystic fluid, and the increased pressure in the cyst cavity compresses the surrounding bone resorption. Using a negative pressure forming device to form negative pressure stress in the cyst cavity has a stronger promoting effect on the formation and reconstruction of new bone at the restoration-bone interface, and can promote the formation of new bone. In the surgical area, due to continuous secretions in the surgical area, it is often necessary to leave a negative pressure suction device in the surgical area to discharge tissue exudate, and reserved flushing pipes can better discharge tissue exudate. Experiments have shown that low-intensity intermittent negative pressure in vitro can successfully induce MSCs to grow and differentiate into osteoblasts and promote osteogenic activity. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 This is a schematic diagram of the overall structure of the jaw after repair in Example 1;

[0024] Figure 2 This is a schematic diagram of the negative pressure suction pipeline and the reserved flushing pipeline in Example 1.

[0025] The numbers in the figure are listed as follows:

[0026] 1-base, 2-flushing hole, 3-bone end, 4-tube opening, 5-periosteum, 6-negative pressure suction pipe, 7-through hole, 8-reserved flushing pipe. DETAILED DESCRIPTION

[0027] In order to better understand the present invention, the present invention is specifically described below by way of examples. It is necessary to point out here that the following examples are only used to further illustrate the present invention and cannot be understood as limiting the scope of protection of the present invention. Some non-essential improvements and adjustments made by professionals and technicians in this field according to the content of the present invention above still belong to the scope of protection of the present invention.

[0028] Example

[0029] This embodiment is a case where the jaw bone is defective but the periosteum is still present. Figure 1 As shown, a negative pressure drainage prosthesis for jaw defect of this embodiment includes a base 1, the two ends of the base 1 are tightly fitted and fixed with the bone ends 3, and the outer surface can be in contact with the jaw periosteum 10. The inside of the base 1 has a negative pressure suction pipeline 6 running through it, and the outer pipe opening 4 is used to connect the negative pressure suction device. The wall of the negative pressure suction pipeline 6 is distributed with through holes 7. The outer periphery of the negative pressure suction pipeline 6 is surrounded by a reserved flushing pipeline 8, and the outer periphery of the reserved flushing pipeline 8 is distributed with flushing holes 9.

[0030] The diameter of the negative pressure suction pipe is 10-20 mm, preferably 15 mm in this embodiment, and the average diameter of the through holes is 1 mm, with a density of 3-6 holes / cm 2.

[0031] The pressure value of the negative pressure applied is 125-450 mmHg, which is adjusted according to time and status, and intermittent negative pressure suction is performed for 15-30 minutes / hour.

[0032] In this embodiment, due to the presence of the periosteum 10, the prosthesis cannot and does not need to be made into a closed environment. The negative pressure suction pipe 6 penetrates deep into the entire prosthesis and can cooperate with the periosteum to form a negative pressure environment sufficient for auxiliary treatment.

[0033] According to tests, the bone formation speed of this embodiment is increased by more than 30% compared with the existing technology, and the bone formation amount is increased by more than 50% compared with the existing technology.

[0034] The above is only a preferred embodiment of the present invention and is not intended to limit the invention in other forms. Any technician familiar with the profession may use the technical content disclosed above to change or modify it into an equivalent embodiment with equivalent changes. However, any simple modification, equivalent change and modification made to the above embodiment based on the technical essence of the present invention without departing from the content of the technical solution of the present invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. A periosteum-retaining mandibular defect negative pressure prosthesis with flushing function, characterized in that The invention comprises a substrate, which is a titanium alloy mesh structure formed by 3D printing. The two ends of the substrate can fit closely with the broken ends of the bone, and the outer surface can contact and fit with the periosteum of the mandible. The interior of the substrate is provided with a penetrating negative pressure suction pipe, and the outer pipe opening can be connected to a negative pressure suction device. The tube wall of the negative pressure suction pipe is provided with through holes formed by the titanium alloy mesh structure. The outer periphery of the negative pressure suction pipe is surrounded by a reserved flushing pipe, and the outer periphery of the reserved flushing pipe is provided with flushing holes.

2. The restoration according to claim 1, characterized in that The diameter of the negative pressure suction pipe is 10-20 mm.

3. The restoration according to claim 2, characterized in that The diameter of the negative pressure suction pipe is 15 mm.

4. The restoration according to claim 1, characterized in that The average diameter of the through holes is 1 mm, and the density is 3-6 per cm 2 .

5. The restoration according to claim 1, characterized in that The pressure value of the negative pressure applied is 125-450 mmHg.

6. The restoration according to claim 1, characterized in that Perform intermittent vacuum suction for 15-30 minutes / hour.

7. The restoration according to claim 1, characterized in that The reticular structure is a bone trabecular structure.

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