A jaw bone defect negative pressure repair body with flushing function and remaining periosteum

Abstract

The application discloses a jaw bone defect negative pressure repair body with a flushing function and a preserved periosteum, which comprises a base body, the base body is a titanium alloy net structure formed by 3D printing, two ends of the base body are adapted to be attached to bone broken ends, and an outer surface of the base body is adapted to be contacted with jaw bone periosteum, the base body is internally provided with a negative pressure suction pipeline penetrating through the base body, an outer pipe opening of the negative pressure suction pipeline is connectable to a negative pressure suction device, a pipe wall of the negative pressure suction pipeline is distributed with through holes formed by the titanium alloy net structure, and a reserved flushing pipeline is arranged around an outer periphery of the negative pressure suction pipeline, and the reserved flushing pipeline is distributed with flushing holes around the outer periphery. The repair body has the following functions: promoting growth and differentiation of osteoblasts on the surface of the bone broken ends and the periosteum, and promoting new bone formation; and being capable of discharging tissue exudates and the like out of the body.

Description

Technical Field

[0001] This invention belongs to the clinical field of oral and maxillofacial surgery, specifically relating to a drainage prosthesis for jawbone defects. Background Technology

[0002] Jawbone defects caused by factors such as trauma, tumors, and infections not only affect patients' normal physiological functions but also cause facial deformities, impacting their chewing, swallowing, and speech abilities, and severely affecting their mental health. Jawbone repair and reconstruction has long been a major clinical challenge. Currently, while methods such as autologous bone grafting, allogeneic bone grafting, distraction osteogenesis, and artificial replacement materials are used clinically, their application remains significantly limited due to surgical complexity, limited material sources, and the risk of rejection.

[0003] Currently, negative pressure drainage has been studied in clinical treatment. The principle behind negative pressure drainage is that negative pressure can accelerate the transformation of highly proliferating active epithelium and bone remodeling at the capsule-bone interface towards the cavity, thereby greatly shortening the treatment course. Furthermore, the negative pressure environment isolates the oral cavity from its bacterial environment, significantly reducing the chance of infection. However, in clinical applications of jawbone defect repair, negative pressure suction devices are required for drainage of the surgical area. Currently, there are no jawbone implants or prostheses that can be directly connected to external negative pressure drainage. Summary of the Invention

[0004] To address the above technical problems, this invention provides a negative pressure prosthesis for jawbone defects with preserved periosteum and a flushing function.

[0005] The technical solution of the present invention is as follows:

[0006] A negative pressure prosthesis for jawbone defects with periosteal retention and irrigation function is characterized by comprising a matrix, wherein the matrix is ​​a titanium alloy mesh structure formed by 3D printing, the two ends of the matrix can be fitted to the bone fracture ends, the outer surface can be fitted to the periosteum of the jawbone, the matrix has a through negative pressure suction channel inside, the outer opening of the channel can be connected to a negative pressure suction device, and the wall of the negative pressure suction channel is distributed with through holes formed by the titanium alloy mesh structure.

[0007] Preferably, the diameter of the negative pressure suction pipe is 10-20 mm.

[0008] More preferably, the diameter of the negative pressure suction pipe is 15mm.

[0009] Preferably, the negative pressure suction pipe is surrounded by a reserved flushing pipe, and the reserved flushing pipe has flushing holes distributed around its outer periphery.

[0010] Preferably, the average diameter of the through holes is 1 mm, and the density is 3-6 holes / cm³. 2 .

[0011] Preferably, the applied negative pressure is 125-450 mmHg.

[0012] Preferably, intermittent negative pressure suction is performed for 15-30 minutes per hour.

[0013] Preferably, the mesh structure is a bone-like trabecular structure.

[0014] The beneficial effects of this invention are as follows:

[0015] In recent years, additive manufacturing technology has gradually emerged in the field of bone defect repair, becoming a popular research and application area. Compared with traditional subtractive manufacturing technology, additive manufacturing has unique advantages. It can not only produce prostheses that perfectly match the shape of the mandible, but also precisely control the internal structure of the prosthesis, thereby producing prostheses that meet both morphological requirements and promote bone function repair.

[0016] This invention utilizes additive manufacturing technology to obtain a prosthesis matrix that conforms to the shape of the jawbone loss site through 3D printing. Furthermore, based on the presence or absence of the periosteum, two types of prostheses are designed for use with negative pressure suction devices for negative pressure-assisted treatment.

[0017] Specifically, this invention addresses jawbone defects where the periosteum is still intact. A 3D-printed titanium alloy prosthesis is used, with both ends tightly fitted to the bone fracture ends. The outer surface is porous, contacting the jawbone periosteum, and the interior features a trabecular mesh structure. Internally, a negative pressure suction channel runs throughout the entire prosthesis, allowing for intermittent negative pressure suction. Due to the presence of the periosteum, the prosthesis is not designed as a closed environment; the negative pressure suction channel extends deep into the entire prosthesis, promoting accelerated growth and differentiation of osteoblasts in the periosteal tissue and bone fracture ends under negative pressure, thus facilitating rapid, multi-directional osteogenic repair of the prosthesis from the outside in.

[0018] The above-mentioned prostheses have the following functions:

[0019] 1. Promotes the growth and differentiation of osteoblasts at bone ends and on the periosteum, thus promoting new bone formation;

[0020] 2. It can drain tissue exudate and other fluids from the body;

[0021] 3. The reserved flushing tubes can also be used for saline flushing when necessary, reducing the risk of infection in the surgical area.

[0022] Experiments have shown that in vitro low-intensity intermittent negative pressure can successfully induce MSCs to differentiate into osteoblasts. Furthermore, the main cause of bone resorption in jawbone cysts is the secretion of cyst fluid from the cyst wall, leading to increased pressure within the cyst cavity and subsequent bone resorption. Using a negative pressure generating device to create negative pressure stress within the cyst cavity has a stronger promoting effect on new bone formation and remodeling at the prosthesis-bone interface, thus promoting new bone formation. In the surgical area, due to continuous secretions, it is often necessary to leave a negative pressure suction device in place to drain tissue exudate. Pre-installed irrigation channels can better facilitate the drainage of tissue exudate. Experiments have shown that in vitro low-intensity intermittent negative pressure can successfully induce MSCs to differentiate into osteoblasts, promoting osteogenic activity. Attached Figure Description

[0023] Figure 1 This is a schematic diagram of the overall structure of the jawbone after repair in Example 1;

[0024] Figure 2 This is a schematic diagram of the negative pressure suction pipe and the reserved flushing pipe in Example 1.

[0025] The labels in the diagram are listed below:

[0026] 1-Matrix, 2-Flushing hole, 3-Bone fracture end, 4-Port, 5-Periosteum, 6-Negative pressure suction pipe, 7-Through hole, 8-Reserved flushing pipe. Detailed Implementation

[0027] To better understand the present invention, specific descriptions are provided below through embodiments. It should be noted that the following embodiments are for further illustration only and should not be construed as limiting the scope of protection of the present invention. Non-essential improvements and adjustments made by those skilled in the art based on the above description of the present invention still fall within the scope of protection of the present invention.

[0028] Example

[0029] This example illustrates a case of jawbone defects where the periosteum still exists. Figure 1 As shown, a negative pressure drainage prosthesis for jawbone defects according to this embodiment includes a base 1. Both ends of the base 1 are tightly fitted and fixed to the bone fracture ends 3. The outer surface can contact and fit with the periosteum 10 of the jawbone. The interior of the base 1 has a through negative pressure suction pipe 6, and the outer opening 4 is used to connect a negative pressure suction device. Through holes 7 are distributed on the wall of the negative pressure suction pipe 6. A reserved flushing pipe 8 surrounds the negative pressure suction pipe 6, and flushing holes 9 are distributed on the outer periphery of the reserved flushing pipe 8.

[0030] The diameter of the negative pressure suction pipe is 10-20mm, preferably 15mm in this embodiment, and the average diameter of the through holes is 1mm, with a density of 3-6 holes / cm³. 2.

[0031] The applied negative pressure is 125-450 mmHg, and the pressure is adjusted according to the time and condition, with intermittent negative pressure suction for 15-30 minutes per hour.

[0032] In this embodiment, due to the presence of the periosteum 10, the prosthesis cannot and does not need to be made into a closed environment. The negative pressure suction tube 6 extends into the entire prosthesis, which can work with the periosteum to form a sufficiently negative pressure environment to assist in treatment.

[0033] Experiments have shown that the osteogenic rate of this embodiment is increased by more than 30% and the amount of bone formed is increased by more than 50% compared with the prior art.

[0034] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention in any other way. Any person skilled in the art may make changes or equivalent modifications to the above-disclosed technical content. However, any simple modifications, equivalent changes, and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the protection scope of the present invention.

Claims

1. A jaw bone defect negative pressure repair body with a flushing function and a preserved periosteum, characterized in that, The application relates to a titanium alloy net structure for 3D printing, which is a bone trabecula structure, and is suitable for fitting with bone ends, and has a porous outer surface which can contact and fit with the bone periosteum, and has a negative pressure suction pipeline in the inside, and the outer tube opening can be connected with a negative pressure suction device, and the negative pressure suction pipeline wall is provided with through holes formed by the titanium alloy net structure, and the negative pressure suction pipeline is surrounded by a reserved flushing pipeline, and the reserved flushing pipeline is provided with flushing holes, and the negative pressure suction pipeline diameter is 10-20 mm, the average diameter of the through holes is 1 mm, the density is 3-6 / cm 2 , and the applied negative pressure pressure value is 125-450 mmHg.

2. The restoration of claim 1, wherein The negative pressure suction pipe has a diameter of 15 mm.

3. The restoration of claim 1, wherein Intermittent negative pressure suction is performed for 15-30 minutes / hour.

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