Plant extract for improving physiological slow peristalsis and preparation method thereof

Abstract

The embodiment of the invention discloses a plant extract for improving physiological slow peristalsis and a preparation method of the plant extract, relates to the technical field of traditional Chinese medicine extracts, and aims to solve the technical problems that an existing medicine for improving constipation caused by slow peristalsis is poor in taste, large in dosage, complex in component, insufficient in curative effect stability and the like. The plant extract for improving the slow physiological peristalsis comprises a rhizoma atractylodis extract, a rhizoma atractylodis macrocephalae extract and a radix aucklandiae extract in a mass ratio of (1-3): (1-4): 1. The plant extract disclosed by the invention is clear in component, exact in content, stable in process and controllable in product quality, has a good effect of promoting peristalsis, and can be applied to foods and medicines.

Description

Technical Field

[0001] The present application relates to the technical field of Chinese medicine extracts, and in particular to a plant extract for improving physiological slow intestinal motility and a preparation method thereof. Background Art

[0002] The causes of slowed intestinal motility, that is, difficulty in defecation or reduced frequency of defecation, are complex and varied. With age, the elasticity of intestinal muscles and nerve function of the elderly may decrease, resulting in slower intestinal motility. During pregnancy, pregnant women may also experience slower intestinal motility due to changes in hormone levels, pressure from the uterus on the intestine, and changes in diet and lifestyle. White-collar workers have reduced intestinal activity due to long periods of sitting at work and lack of exercise, which in turn affects intestinal motility. An unbalanced diet, insufficient intake of fiber and water, and excessive intake of fat and processed foods are also important factors in constipation. In addition, certain drugs, including analgesics, antidepressants, antibiotics, iron supplements, etc., may interfere with normal intestinal motility. Chronic diseases, such as thyroid dysfunction, diabetes, colitis, etc., may also lead to slower intestinal motility. Psychological factors, such as stress, anxiety, depression, etc., may also have a negative impact on intestinal function, thereby slowing down intestinal motility.

[0003] To address the problem of slowed intestinal motility, the main treatment currently used is drugs, including chemical drugs and Chinese herbal compound preparations. Stimulant laxatives and osmotic laxatives are effective in the short term, but tolerance varies among individuals. Long-term and frequent use may lead to dependence and side effects, and long-term use may weaken the natural bowel movement function of the intestines, resulting in poor therapeutic effects. Lubricating drugs such as enema are also inconvenient to use for a long time. Traditional Chinese medicine usually uses dialectical treatment and prescription decoction to treat constipation, but there are problems such as poor taste of oral drugs, large dosage, complex ingredients, and insufficient stability of efficacy, which limits its scope of application. Acupuncture and massage treatments also have limitations such as cumbersome treatment process and inconvenient application.

[0004] Therefore, developing a product with a simple formula, clear active ingredients, accurate content, definite efficacy, and easy to take and carry is an issue that urgently needs to be addressed in the current market demand. Summary of the invention

[0005] The main purpose of the present application is to provide a plant extract for improving physiological slow intestinal motility and a preparation method thereof, aiming to solve the technical problems of existing drugs for improving constipation caused by slow intestinal motility, such as poor taste, large dosage, complex ingredients, and insufficient stability of therapeutic effect.

[0006] To achieve the above objectives, the technical solutions adopted in the embodiments of the present application are as follows:

[0007] In a first aspect, an embodiment of the present application provides a plant extract for improving physiological slow intestinal motility, wherein the plant extract comprises an Atractylodes lancea extract, a White Atractylodes macrocephala extract and a Costusroot lappa extract in a mass ratio of 1 to 3:1 to 4:1.

[0008] As some optional embodiments of the present application, the plant extract includes Atractylodes lancea extract, Atractylodes macrocephala extract and Costusroot rhizome extract in a mass ratio of 2:2:1.

[0009] In a second aspect, the present invention provides a method for preparing a plant extract for improving physiological slow intestinal motility as described above, comprising the following steps:

[0010] Atractylodes lancea extract, Atractylodes macrocephala extract and Aucklandia lappa extract are prepared respectively;

[0011] The Atractylodes lancea extract, the Atractylodes macrocephala extract and the Costusroot lappa extract are mixed at a mass ratio of 1 to 3:1 to 4:1 to obtain a plant extract for improving physiological slow intestinal motility.

[0012] As some optional embodiments of the present application, the Atractylodes lancea extract is prepared by the following steps: take undried Atractylodes lancea, crush it, pass it through a 10-20 mesh sieve, add 4-6 times the amount of water, distill and extract for 3-5 hours, collect volatile oil, filter the aqueous solution, add 5%-20% ethyl acetate to the filtrate and extract it twice, combine the ethyl acetate liquid, evaporate the ethyl acetate at low temperature, and combine it with the volatile oil to obtain.

[0013] As some optional embodiments of the present application, the Atractylodes lancea is selected as the fresh rhizome of Atractylodes lancea or Atractylodes lancea of ​​the Asteraceae family.

[0014] As some optional embodiments of the present application, the Atractylodes macrocephala extract is prepared by the following steps: undried Atractylodes macrocephala is crushed, passed through a 10-20 mesh sieve, 4-6 times the amount of water is added, and distilled for 4-6 hours, the volatile oil is collected, the aqueous solution is filtered, and the filtrate is extracted twice with 5%-20% ethyl acetate, the ethyl acetate liquid is combined, the ethyl acetate is evaporated at low temperature, and the extract is combined with the volatile oil.

[0015] As some optional embodiments of the present application, the Atractylodes macrocephala is the fresh rhizome of the Atractylodes macrocephala plant of the Asteraceae family.

[0016] As some optional embodiments of the present application, the costus root extract is prepared by the following steps: crushing the costus root into fine powder, passing through a 20-40 mesh sieve, adding 6 times the amount of water, adding 0.5% cellulase complex, stirring evenly, enzymolysis time 2.5 to 4 hours, enzymolysis temperature 46°C to 52°C, then distilling and extracting for 3 hours, collecting volatile oil, filtering the aqueous solution, adding 5%-30% ethyl acetate to the filtrate for extraction twice, combining the ethyl acetate solutions, evaporating the ethyl acetate at low temperature, and combining with the volatile oil to obtain.

[0017] As some optional embodiments of the present application, the cellulase complex comprises one, two or three of cellulase, hemicellulase and endo-1,4-β-xylanase.

[0018] As some optional embodiments of the present application, the mixing mass ratio of cellulase:hemicellulase:endo-1,4-β-xylanase in the cellulase complex is 3:1:1.

[0019] Compared with the prior art, the technical advancement of this application is:

[0020] The present application can effectively remove a large number of ineffective components in plants, thereby achieving the enrichment of effective components and significantly increasing the content of effective components in the extract. According to the content determination results of high performance liquid chromatography (HPLC), the process shows good stability and reliability, and the quality of the obtained extract has good controllability and consistency between batches, which provides favorable conditions for industrial production.

[0021] The mouse small intestine propulsion experiment verified that the present application has a significant promoting effect on the intestinal peristalsis of mice, and the difference is statistically significant compared with the blank control group.

[0022] Compared with the prior art, the present application provides a plant extract composition that can improve the condition of slow intestinal peristalsis, which can be used as a substitute for existing similar products and is suitable for people with constipation problems caused by unbalanced diet, high work pressure, old age and frailty, etc. The plant raw materials used are all from the list of Chinese medicinal materials that can be used for health foods, ensuring the high safety of the product.

[0023] The preparation of the costus root extract in the present application adopts a cellulose enzymatic hydrolysis process, which not only increases the types of costus root active ingredients, but also improves the extraction rate, thereby improving the utilization efficiency of plant resources. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 HPLC chromatogram of the reference substance involved in the examples of this application;

[0025] Figure 2 HPLC chromatogram of the sample of the plant extract involved in the embodiment of the present application;

[0026] In the figure, 1-costunolide, 2-atractylodes lactone, and 3-atractylodisin. DETAILED DESCRIPTION

[0027] It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0028] Slowed intestinal motility, that is, difficulty or reduced frequency of defecation, is caused by decreased intestinal function in the elderly, hormonal changes and changes in eating habits in pregnant women, long-term sitting and lack of exercise for white-collar workers, unbalanced diet, side effects of certain drugs, and the influence of chronic diseases and mental factors. The treatment of constipation mainly relies on drugs, but there are problems of dependence and side effects. Although traditional Chinese medicine treatment is dialectical, it has problems such as poor taste and insufficient stability of efficacy. Therefore, the development of a simple, clear, accurate, effective, easy to take and carry product is an urgent problem that needs to be solved in the market.

[0029] For specific groups such as the elderly, young children, and office workers who sit for long periods of time, the intestinal motility slows down due to their physiological characteristics, which in turn causes constipation. This application aims to develop a plant extract with a clear active ingredient, a stable and controllable content, and a small dosage to improve the physiological slow intestinal motility. In addition, this application is also committed to providing a composition of the above-mentioned plant extract, which is suitable for preparing a medicine or health food for regulating or improving constipation-related diseases.

[0030] Specifically, the plant extract for improving physiological slow intestinal motility described in the present application includes an Atractylodes lancea extract, a White Atractylodes macrocephala extract and a Costus root extract in a mass ratio of 1 to 3:1 to 4:1; wherein the percentage of atractylodesin in the Atractylodes lancea extract is 16.59%, the percentage of atractylodes lactone in the White Atractylodes macrocephala extract is 0.85%, and the percentage of costusin lactone in the Costus root extract is 0.52%.

[0031] In a preferred embodiment, the plant extract comprises an Atractylodes lancea extract, a White Rhizome extract and a Costusroot extract in a mass ratio of 2:2:1.

[0032] With respect to the above-mentioned plant extract for improving physiological slow intestinal motility, the present application also provides a preparation method thereof, comprising the following steps:

[0033] Atractylodes lancea extract, Atractylodes macrocephala extract and Aucklandia lappa extract are prepared respectively;

[0034] The Atractylodes lancea extract, the Atractylodes macrocephala extract and the Costusroot lappa extract are mixed at a mass ratio of 1 to 3:1 to 4:1 to obtain a plant extract for improving physiological slow intestinal motility.

[0035] Specifically, the extract of Atractylodes lancea, the extract of Atractylodes macrocephala and the extract of Aucklandia lappa were prepared respectively;

[0036] The Atractylodes lancea extract, the Atractylodes macrocephala extract and the Costusroot lappa extract are mixed at a mass ratio of 1 to 3:1 to 4:1 to obtain a plant extract for improving physiological slow intestinal motility.

[0037] Specifically, the Atractylodes lancea extract is prepared by the following steps: taking undried Atractylodes lancea, crushing it, passing it through a 10-20 mesh sieve, adding 4-6 times the amount of water, distilling and extracting it for 3-5 hours, collecting volatile oil, filtering the aqueous solution, adding 5%-20% ethyl acetate (volume ratio) to the filtrate for extraction twice, combining the ethyl acetate solutions, evaporating the ethyl acetate at low temperature, and combining it with the volatile oil to obtain the extract.

[0038] Specifically, the Atractylodes macrocephala extract is prepared by the following steps: undried Atractylodes macrocephala is crushed, passed through a 10-20 mesh sieve, 4-6 times of water is added, distilled and extracted for 4-6 hours, volatile oil is collected, the water solution is filtered, 5%-20% ethyl acetate (volume ratio) is added to the filtrate, and extracted twice, the ethyl acetate solution is combined, the ethyl acetate is evaporated at low temperature, and the extract is combined with the volatile oil to obtain the extract.

[0039] Specifically, the costus root extract is prepared by the following steps: crushing the costus root into fine powder, passing through a 20-40 mesh sieve, adding 6 times the amount of water, adding 0.5% cellulose enzyme complex (by mass fraction), stirring evenly, enzymolysis time 2.5-4h, enzymolysis temperature 46°C-52°C, then distilling and extracting for 3h, collecting volatile oil, filtering the water solution, adding 5%-30% ethyl acetate (volume ratio) to the filtrate for extraction twice, combining the ethyl acetate solution, evaporating the ethyl acetate at low temperature, and combining it with the volatile oil to obtain the product.

[0040] It should be noted that the Atractylodes lancea is selected from the fresh rhizome of Atractylodes lancea (Thunb.) DC. or Atractylodes chinensis (DC.) Koidz. of the Asteraceae family. The Atractylodes macrocephala is the fresh rhizome of Atractylodes macrocephala Koidz. of the Asteraceae family. The cellulase complex comprises a mixture of one, two or three of cellulase, hemicellulase and endo-1,4-β-xylanase. Preferably, the mixing mass ratio of cellulase: hemicellulase: endo-1,4-β-xylanase in the cellulase complex is 3:1:1.

[0041] In addition, the plant extract for improving physiological slow intestinal motility described in the present application can also be used in the preparation of products for treating or improving physiological slow intestinal motility. The composition provided in the present application can be added as a whole to the preparation of different products, including food and medicine, to achieve the effect of improving intestinal motility.

[0042] In order to facilitate those skilled in the art to understand the technical solution described in this application, the technical solution of this application is further described in detail below in conjunction with specific embodiments:

[0043] Example 1

[0044] Take undried Atractylodes lancea, crush it, pass it through a 10-mesh sieve, add 5 times the amount of water, distill and extract for 3 hours, collect the volatile oil, filter the water solution, add 7% ethyl acetate (volume ratio) to the filtrate and extract it twice, combine the ethyl acetate solution, evaporate the ethyl acetate at low temperature, and combine it with the volatile oil to obtain the Atractylodes lancea extract;

[0045] The undried Atractylodes macrocephala is crushed, passed through a 10-mesh sieve, and 5 times the amount of water is added. The volatile oil is collected, the aqueous solution is filtered, and the filtrate is extracted twice with 10% ethyl acetate (volume ratio). The ethyl acetate solution is combined, the ethyl acetate is evaporated at low temperature, and the volatile oil is combined to obtain the Atractylodes macrocephala extract;

[0046] The root of costus root was crushed into fine powder, passed through a 40-mesh sieve, added with 6 times the amount of water, added with 0.5% mixed enzyme (cellulase: hemicellulase: endo-1,4-β-xylanase (3:1:1)), stirred evenly, heated to 49°C, enzymatic hydrolysis time 2.5h, then distilled and extracted for 3h, the volatile oil was collected, the aqueous solution was filtered, 15% ethyl acetate (volume ratio) was added to the filtrate and extracted twice, the ethyl acetate liquid was combined, the ethyl acetate was evaporated at low temperature, and combined with the volatile oil to obtain the costus root extract.

[0047] The Atractylodes lancea extract, the Atractylodes macrocephala extract and the Costusroot lappa extract are mixed at a mass ratio of 1:1:1 to obtain a plant extract for improving physiological slow intestinal motility.

[0048] Example 2

[0049] Take undried Atractylodes lancea, crush it, pass it through a 10-mesh sieve, add 5 times the amount of water, distill and extract for 3 hours, collect the volatile oil, filter the water solution, add 7% ethyl acetate (volume ratio) to the filtrate and extract it twice, combine the ethyl acetate solution, evaporate the ethyl acetate at low temperature, and combine it with the volatile oil to obtain the Atractylodes lancea extract;

[0050] The undried Atractylodes macrocephala is crushed, passed through a 10-mesh sieve, and 5 times the amount of water is added. The volatile oil is collected, the aqueous solution is filtered, and the filtrate is extracted twice with 10% ethyl acetate (volume ratio). The ethyl acetate solution is combined, the ethyl acetate is evaporated at low temperature, and the volatile oil is combined to obtain the Atractylodes macrocephala extract;

[0051] The root of costus root was crushed into fine powder, passed through a 40-mesh sieve, added with 6 times the amount of water, added with 0.5% mixed enzyme (cellulase: hemicellulase: endo-1,4-β-xylanase (3:1:1)), stirred evenly, heated to 49°C, enzymatic hydrolysis time 2.5h, then distilled and extracted for 3h, the volatile oil was collected, the aqueous solution was filtered, 15% ethyl acetate (volume ratio) was added to the filtrate and extracted twice, the ethyl acetate liquid was combined, the ethyl acetate was evaporated at low temperature, and combined with the volatile oil to obtain the costus root extract.

[0052] The Atractylodes lancea extract, the Atractylodes macrocephala extract and the Costusroot lappa extract are mixed at a mass ratio of 1:2:1 to obtain a plant extract for improving physiological slow intestinal motility.

[0053] Example 3

[0054] Take undried Atractylodes lancea, crush it, pass it through a 10-mesh sieve, add 5 times the amount of water, distill and extract for 3 hours, collect the volatile oil, filter the water solution, add 7% ethyl acetate (volume ratio) to the filtrate and extract it twice, combine the ethyl acetate solution, evaporate the ethyl acetate at low temperature, and combine it with the volatile oil to obtain the Atractylodes lancea extract;

[0055] The undried Atractylodes macrocephala is crushed, passed through a 10-mesh sieve, and 5 times the amount of water is added. The volatile oil is collected, the aqueous solution is filtered, and the filtrate is extracted twice with 10% ethyl acetate (volume ratio). The ethyl acetate solution is combined, the ethyl acetate is evaporated at low temperature, and the volatile oil is combined to obtain the Atractylodes macrocephala extract;

[0056] The root of costus root was crushed into fine powder, passed through a 40-mesh sieve, added with 6 times the amount of water, added with 0.5% mixed enzyme (cellulase: hemicellulase: endo-1,4-β-xylanase (3:1:1)), stirred evenly, heated to 49°C, enzymatic hydrolysis time 2.5h, then distilled and extracted for 3h, the volatile oil was collected, the aqueous solution was filtered, 15% ethyl acetate (volume ratio) was added to the filtrate and extracted twice, the ethyl acetate liquid was combined, the ethyl acetate was evaporated at low temperature, and combined with the volatile oil to obtain the costus root extract.

[0057] The Atractylodes lancea extract, the Atractylodes macrocephala extract and the Costusroot lappa extract are mixed at a mass ratio of 2:1:1 to obtain a plant extract for improving physiological slow intestinal motility.

[0058] Example 4

[0059] Take undried Atractylodes lancea, crush it, pass it through a 10-mesh sieve, add 5 times the amount of water, distill and extract for 3 hours, collect the volatile oil, filter the water solution, add 7% ethyl acetate (volume ratio) to the filtrate and extract it twice, combine the ethyl acetate solution, evaporate the ethyl acetate at low temperature, and combine it with the volatile oil to obtain the Atractylodes lancea extract;

[0060] The undried Atractylodes macrocephala is crushed, passed through a 10-mesh sieve, and 5 times the amount of water is added. The volatile oil is collected, the aqueous solution is filtered, and the filtrate is extracted twice with 10% ethyl acetate (volume ratio). The ethyl acetate solution is combined, the ethyl acetate is evaporated at low temperature, and the volatile oil is combined to obtain the Atractylodes macrocephala extract;

[0061] The root of costus root was crushed into fine powder, passed through a 40-mesh sieve, added with 6 times the amount of water, added with 0.5% mixed enzyme (cellulase: hemicellulase: endo-1,4-β-xylanase (3:1:1)), stirred evenly, heated to 49°C, enzymatic hydrolysis time 2.5h, then distilled and extracted for 3h, the volatile oil was collected, the aqueous solution was filtered, 15% ethyl acetate (volume ratio) was added to the filtrate and extracted twice, the ethyl acetate liquid was combined, the ethyl acetate was evaporated at low temperature, and combined with the volatile oil to obtain the costus root extract.

[0062] The Atractylodes lancea extract, the Atractylodes macrocephala extract and the Costusroot lappa extract are mixed at a mass ratio of 2:2:1 to obtain a plant extract for improving physiological slow intestinal motility.

[0063] Example 5

[0064] Take undried Atractylodes lancea, crush it, pass it through a 10-mesh sieve, add 5 times the amount of water, distill and extract for 3 hours, collect the volatile oil, filter the water solution, add 7% ethyl acetate (volume ratio) to the filtrate and extract it twice, combine the ethyl acetate solution, evaporate the ethyl acetate at low temperature, and combine it with the volatile oil to obtain the Atractylodes lancea extract;

[0065] The undried Atractylodes macrocephala is crushed, passed through a 10-mesh sieve, and 5 times the amount of water is added. The volatile oil is collected, the aqueous solution is filtered, and the filtrate is extracted twice with 10% ethyl acetate (volume ratio). The ethyl acetate solution is combined, the ethyl acetate is evaporated at low temperature, and the volatile oil is combined to obtain the Atractylodes macrocephala extract;

[0066] The root of costus root was crushed into fine powder, passed through a 40-mesh sieve, added with 6 times the amount of water, added with 0.5% mixed enzyme (cellulase: hemicellulase: endo-1,4-β-xylanase (3:1:1)), stirred evenly, heated to 49°C, enzymatic hydrolysis time 2.5h, then distilled and extracted for 3h, the volatile oil was collected, the aqueous solution was filtered, 15% ethyl acetate (volume ratio) was added to the filtrate and extracted twice, the ethyl acetate liquid was combined, the ethyl acetate was evaporated at low temperature, and combined with the volatile oil to obtain the costus root extract.

[0067] The Atractylodes lancea extract, the Atractylodes macrocephala extract and the Costusroot lappa extract are mixed at a mass ratio of 2:4:1 to obtain a plant extract for improving physiological slow intestinal motility.

[0068] Example 6

[0069] A plant extract for improving physiological slow intestinal motility is prepared from the following extracts in parts by mass: 20 parts of atractylodesin (purity ≥ 98%), 12 parts of atractylodes lactone (purity ≥ 99.9%), and 1 part of costus alcohol lactone (purity 99.6%).

[0070] Experimental Example 1

[0071] Preparation of plant extract soft capsules: Take the plant extracts prepared in Examples 1 to 6, and prepare a glue material by mixing gelatin, water and glycerin according to the soft capsule preparation operating specifications. After adding 0.3% titanium dioxide and stirring evenly, add it to the sol tank and connect it to the spreading box; pour the extract composition into the feeding port, adjust the temperature of the pill pressing chamber to about 20°C, the humidity to 45-55%, the air pressure to about 0.20Mpa, the oil pressure to 0.02Mpa, the material pressure to 0.05Mpa, the roller mold speed to 3RPM, the temperature of the spreading box to 65°C, and take out the pressed soft capsules after 4 hours of shaping. Wash the grease on the surface of the capsule shell with ethanol (food grade) and air-dry them.

[0072] Mouse small intestinal propulsion experiment: The effect of the plant extracts prepared in Examples 1 to 6 on the small intestinal motility function was investigated using the ink propulsion rate.

[0073] Experimental method: Take 30 Kunming mice, half male and half female, randomly divided into five groups, each group has 6 mice, namely, implementation 2, embodiment 4, embodiment 6 (dosage: 50 mg / kg), positive drug (morpholine) group (10 mg / kg) and blank control group (normal saline group). Fasting but not water, oral administration after 24 hours, 0.1 ml of ink per mouse oral administration after 30 minutes, cervical vertebra dislocation after 30 minutes, dissection to get small intestine, cut the intestinal tube from pylorus to ileocecum, measure the length, take the distance from pylorus to the front edge of ink as the distance of ink advancement in the intestine, calculate the ink advancement rate.

[0074] Experimental results: Each drug-administered group had a significant promoting effect on the intestinal peristalsis of mice, and there were significant differences compared with the blank control group (P<0.05 or P<0.01). The plant extracts prepared in Examples 1 to 6 had different effects on promoting intestinal peristalsis. The results are shown in Table 1.

[0075] Table 1 Effects on small intestinal motility of mice ( n=6)

[0076]

[0077] Note: Compared with the blank control group, *P<0.05, **P<0.01, ***P<0.001. Compared with the positive drug group, #P<0.05, ##P<0.01, ###P<0.001.

[0078] Among them, the HPLC chromatogram of the reference substance is as follows Figure 1 As shown, the sample HPLC chromatogram of the plant extract described in Example 4 of the present application is as follows Figure 2 As shown, Figure 1-Figure 2 1 in all of them represents costunolide, 2 represents atractylodes lactone, and 3 represents atractylodesin. Figure 1 and Figure 2The peak area of ​​each component can be further quantified to further quantify the content of costunolide, atractylodes lactone and atractylodesin in the plant extract in Example 4. A new composition (Example 6) is composed according to the content of the three components to obtain a plant extract product with higher medicinal efficacy, providing a better treatment plan for patients with physiological slow intestinal peristalsis.

[0079] In summary, the present application discloses a plant extract for improving physiological slow intestinal peristalsis and a preparation method thereof, including an Atractylodes lancea extract, a Rhizoma Atractylodis Macrocephalae extract, and a Radix Aucklandiae extract. The present application discloses a preparation method for the above-mentioned composition, wherein the plant extract composition preferably prepared is composed of a mass ratio of 2:2:1, and the percentage of the effective ingredient Atractylodes lancea is about 16.59%, the percentage of Atractylodes macrocephala lactone is about 0.85%, and the percentage of costusin lactone is about 0.52%. The extract composition has clear ingredients, exact content, stable process, controllable product quality, and has a good effect of promoting intestinal peristalsis, and can be applied to food and medicine.

[0080] The above description is only a preferred embodiment of the present application and is not intended to limit the present application. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims

1. A plant extract for improving physiological slow intestinal motility, characterized in that: The plant extract comprises an Atractylodes lancea extract, a Rhizoma Atractylodis macrocephala extract and a Radix Aucklandiae lappa extract in a mass ratio of 1 to 3:1 to 4:1; The percentage of atractylodesin in the Atractylodes lancea extract is 16.59%, the percentage of atractylodes lactone in the Atractylodes macrocephala extract is 0.85%, and the percentage of costunolide in the costusroot extract is 0.52%.

2. The plant extract for improving physiological slow intestinal motility according to claim 1, characterized in that: The plant extract comprises an atractylodes lancea extract, a white atractylodes macrocephala extract and a costusroot extract in a mass ratio of 2:2:

1.

3. A method for preparing a plant extract for improving physiological slow intestinal motility as claimed in any one of claims 1 to 2, characterized in that: The following steps are involved: Atractylodes lancea extract, Atractylodes macrocephala extract and Aucklandia lappa extract are prepared respectively; The Atractylodes lancea extract, the Atractylodes macrocephala extract and the Costusroot lappa extract are mixed at a mass ratio of 1 to 3:1 to 4:1 to obtain a plant extract for improving physiological slow intestinal motility.

4. The method for preparing the plant extract for improving physiological slow intestinal motility according to claim 3, characterized in that: The Atractylodes lancea extract is prepared by the following steps: taking undried Atractylodes lancea, crushing it, passing it through a 10-20 mesh sieve, adding 4-6 times the amount of water, distilling and extracting it for 3-5 hours, collecting volatile oil, filtering the water solution, adding 5%-20% ethyl acetate to the filtrate for extraction twice, combining the ethyl acetate solution, evaporating the ethyl acetate at low temperature, and combining it with the volatile oil to obtain the extract.

5. The method for preparing the plant extract for improving physiological slow intestinal motility according to claim 4, characterized in that: The Atractylodes lancea is selected from the fresh rhizome of Atractylodes lancea or Atractylodes lancea of ​​the Asteraceae family.

6. The method for preparing the plant extract for improving physiological slow intestinal motility according to claim 3, characterized in that: The Atractylodes macrocephala extract is prepared by the following steps: uncooked Atractylodes macrocephala is crushed, passed through a 10-20 mesh sieve, 4-6 times of water is added, distilled and extracted for 4-6 hours, volatile oil is collected, the aqueous solution is filtered, 5%-20% ethyl acetate is added to the filtrate for extraction twice, the ethyl acetate liquid is combined, the ethyl acetate is evaporated at low temperature, and the extract is combined with the volatile oil to obtain the product.

7. The method for preparing the plant extract for improving physiological slow intestinal motility according to claim 6, characterized in that: The Atractylodes macrocephala is the fresh rhizome of the Atractylodes macrocephala plant of the Asteraceae family.

8. The method for preparing the plant extract for improving physiological slow intestinal motility according to claim 3, characterized in that: The costus root extract is prepared by the following steps: crushing the costus root into fine powder, passing through a 20-40 mesh sieve, adding 6 times the amount of water, adding 0.5% of the cellulase complex, stirring evenly, performing enzymolysis for 2.5-4 hours, and performing enzymolysis at a temperature of 46°C-52°C, then performing distillation extraction for 3 hours, collecting volatile oil, filtering the aqueous solution, adding 5%-30% ethyl acetate to the filtrate for extraction twice, combining the ethyl acetate solutions, evaporating the ethyl acetate at low temperature, and combining with the volatile oil to obtain the product.

9. The method for preparing the plant extract for improving physiological slow intestinal motility according to claim 8, characterized in that: The cellulase complex comprises one, two or three of cellulase, hemicellulase and endo-1,4-β-xylanase.

10. The method for preparing the plant extract for improving physiological slow intestinal motility according to claim 9, characterized in that: The mixing mass ratio of cellulase:hemicellulase:endo-1,4-β-xylanase in the cellulase complex is 3:1:1.

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