External ointment for dispelling wind, eliminating dampness, eliminating stasis, diminishing swelling, promoting blood circulation and relieving pain and preparation method thereof

Abstract

The external ointment is prepared from the following raw materials in parts by mass: 6 parts of flos carthami, 8 parts of radix gentianae macrophyllae, 8 parts of radix clematidis, 6 parts of radix angelicae pubescentis, 6 parts of radix saposhnikoviae, 8 parts of rhizoma chuanxiong, 6 parts of radix achyranthis bidentatae, 5 parts of frankincense, 5 parts of myrrh, 8 parts of radix angelicae sinensis, 8 parts of radix salviae miltiorrhizae, 4 parts of ground beetle, 5 parts of radix et rhizoma rhei, 6 parts of herba artemisiae anomalae, 4 parts of rhizoma curcumae longae, 5 parts of trogopterus dung and 6 parts of rhizoma sparganii. The traditional Chinese medicine is prepared from 4 parts of curcuma zedoary, 4 parts of cowherb seed, 3 parts of borneol, 7 parts of pawpaw, 4 parts of cortex moutan and 4 parts of asarum. According to the invention, the use of radix aconiti preparata and radix aconiti kusnezoffii preparata is reduced, the two medicinal materials contain aconitine, adverse reactions such as poisoning are easily caused by improper use, the new formula avoids potential safety hazards caused by the use of aconitine-containing medicinal materials, the poisoning risk caused by drug toxicity when the ointment is used is reduced, and the ointment is safer and more reliable in the use process; the composition is especially suitable for patients with long-term use or sensitive skin.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine, and in particular to an external ointment that dispels wind and dampness, eliminates blood stasis and swelling, and promotes blood circulation and relieves pain, and a preparation method thereof. Background Art

[0002] Chinese medicine is mainly composed of plant medicine (roots, stems, leaves, fruits), animal medicine (viscera, skin, bones, organs, etc.) and mineral medicine. Because plant medicine accounts for the majority of Chinese medicine, Chinese medicine is also called Chinese herbal medicine. At present, there are about 5,000 kinds of Chinese medicine used in various places, and there are countless prescriptions formed by combining various medicinal materials. Chinese medicine plasters are ground into fine powder for different diseases. Boil water in a purple sand pot, pour the ground Chinese medicine fine powder into the boiling purple sand pot and boil it. The Chinese medicine powder is boiled for 5 minutes while being stirred evenly, and the Chinese medicine powder is boiled into a paste. The boiled Chinese medicine paste is evenly applied on a special medical cotton pad with a bamboo stick and applied to the patient's painful area for fixing. The existing medicinal materials on the market for dispelling wind and dampness, eliminating stasis and swelling, and promoting blood circulation and relieving pain mainly use safflower, processed Chuanwu, processed Caowu, cassia bark, zedoaria, earthworm, rhubarb, Liujinu, turmeric, aconiti lobata, three-edged lancea, curcuma, fenugreek, borneol, dried ginger, natural copper, papaya, moutan bark, firewood, and asarum;

[0003] However, the ointment formula has certain limitations. Processed Chuanwu and processed Caowu contain aconitine. Although processed Chuanwu and processed Caowu have been processed, they still have certain toxicity. Long-term use may cause adverse reactions to the skin and body, and there are certain safety risks. Summary of the invention

[0004] The present invention provides an external ointment capable of dispelling wind and dampness, eliminating blood stasis and swelling, promoting blood circulation and relieving pain, and a preparation method thereof. By reducing the use of processed Chuanwu and processed Caowu, the potential safety hazard caused by the use of aconitine-containing medicinal materials is avoided, the risk of poisoning caused by drug toxicity when the ointment is used is reduced, and the ointment is made safer and more reliable during use. The ointment is particularly suitable for patients who use it for a long time or whose skin is more sensitive.

[0005] In order to achieve the above object, the present invention provides the following technical solution: an external ointment for dispelling wind and dampness, eliminating blood stasis and swelling, promoting blood circulation and relieving pain, the external ointment comprises the following raw materials in parts by mass:

[0006] 6 parts of Carthami, 8 parts of Gentiana macrophylla, 8 parts of Clematidis, 6 parts of Angelica dahurica, 6 parts of Saposhnikovia divaricata, 8 parts of Ligusticum chuanxiong, 6 parts of Achyranthes bidentata, 5 parts of Olibanum, 5 parts of Myrrha, 8 parts of Angelica sinensis, 8 parts of Salvia miltiorrhiza, 4 parts of Eupolyphaga sinensis, 5 parts of Rhubarb, 6 parts of Achyranthes bidentata, 4 parts of Curcuma longa, 5 parts of Ophiopogon japonicus, 6 parts of Sparganium wilfordii, 4 parts of Curcuma longa, 3 parts of Borneolum, 7 parts of Chaenomeles sinensis, 4 parts of Cortex Moutan, 4 parts of Asarum.

[0007] A method for preparing an external ointment for dispelling wind and dampness, eliminating stasis and swelling, and promoting blood circulation and relieving pain, comprising the following steps:

[0008] Step 1, washing and drying the medicinal materials: adjust safflower, gentiana macrophylla, clematis root, angelica dahurica, saposhnikovia divaricata, chuanxiong, cyathula officinalis, angelica sinensis, salvia miltiorrhiza, firewood, retain part of the firewood, adjust to 4 parts, wash asarum separately, remove impurities, and then dry these medicinal materials at room temperature, assuming that the total weight of these medicinal materials is M1;

[0009] Step 2, grinding the medicinal materials into fine powder: take Eupolyphaga sinensis, Rhubarb, Achyranthes bidentata, Curcuma longa, Aconiti Lateralis Preparata, Tripterygium wilfordii, Curcuma zedoaria, Vaccaria segetalis, grind them into fine powder, pass through a 100-mesh sieve, and obtain medicinal powder A. Let the total weight of these medicinal materials after grinding be M2;

[0010] Step 3, extracting the active ingredients with ethanol: taking frankincense and myrrh, placing them in a sealed container, adding an appropriate amount of ethanol, soaking for 72 hours, and then filtering to obtain a frankincense extract, wherein the amount of ethanol is 5 times the total weight of the frankincense and myrrh, assuming that the total weight of the frankincense and myrrh is M3, and extracting the active ingredients therein;

[0011] Step 4, grinding borneol: Take borneol and grind it into very fine powder for later use, and set its weight as M4;

[0012] Step 5, decocting liquid medicine B: adding an appropriate amount of water to the dried medicinal materials in step 1, soaking for 2 hours, then boiling over high heat, then decocting over low heat until 1 / 3 of the original volume of the liquid medicine remains, and filtering to obtain liquid medicine B;

[0013] Step 6, mixing the liquid medicine B and the powder medicine A: Mix the liquid medicine B with the powder medicine A, stir evenly, and obtain a mixture C. This step is to fully integrate the water-soluble and powdery medicinal materials to exert a synergistic effect;

[0014] Step 7, adding the emulsion extract: slowly adding the emulsion extract to the mixture C, stirring while adding to ensure uniform mixing, to obtain a mixture D, wherein stirring is used to promote uniform distribution of different active ingredients;

[0015] Step 8, making an ointment: Finally, add the crushed borneol into mixture D, stir evenly, and make an ointment.

[0016] Preferably, the cleaning and drying of medicinal materials comprises the following steps:

[0017] S1: Place safflower, gentiana macrophylla, clematis root, angelica dahurica, saposhnikovia root, chuanxiong, cyathula, angelica sinensis, salvia miltiorrhiza, radix strychnifoliae, and asarum in different clean containers. Use running water to rinse these herbs. For parts with dirt or a lot of impurities, use a soft brush to gently scrub them to ensure that the impurities on the surface of the herbs are completely removed.

[0018] S2: Drain the rinsed herbs and place them in a clean, well-ventilated place, away from direct sunlight, and let them dry naturally at room temperature. Spread the herbs evenly and turn them over every once in a while to ensure even drying.

[0019] S3: Use a hygrometer to detect the humidity of the medicinal materials. When the humidity of the medicinal materials drops below 10%, it is considered that the drying is completed. Collect the dried medicinal materials together, weigh their total weight and record it as M1, and keep a record.

[0020] Preferably, the grinding of the medicinal material into fine powder comprises the following steps:

[0021] S1: Accurately weigh Eupolyphaga sinensis, Radix Rhei, Rhizoma Cyperi, Rhizoma Curcumae, Rhizoma Aconiti Lateralis, Rhizoma Curcumae, and Rhizoma Vaccariae, using an electronic balance to ensure the accuracy of the weighing, accurate to 0.1g;

[0022] S2: Put the weighed medicinal materials into a mortar, crush them lightly first, and then grind them gradually. You can also use a grinder to grind them. During the grinding process, pay attention to controlling the grinding speed to prevent the medicinal materials from being heated and deteriorating;

[0023] S3: Pass the ground powder through a 100-mesh sieve. If there are coarse particles that do not pass through the sieve, put them back into the mortar or grinder and continue grinding until all of them pass through the sieve to obtain powder A. Weigh the total weight of powder A and record it as M2.

[0024] Preferably, the ethanol extraction of the active ingredient comprises the following steps:

[0025] S1: Accurately weigh frankincense and myrrh, use an electronic balance to ensure accurate weight, record the total weight as M3, and put them into a clean sealed glass container;

[0026] S2: Calculate the required volume V of ethanol according to the formula V=5M3, measure the corresponding volume of ethanol, use a measuring cylinder to accurately measure, ensure that the amount of ethanol meets the requirements, slowly pour the ethanol into a sealed container, ensure that the frankincense and myrrh are completely immersed in the ethanol, and seal the container;

[0027] S3: Place the sealed container in a cool, dry place, ensure that the ambient temperature is between 20℃-25℃, and let it stand for 72 hours. During this period, shake the container appropriately to allow the medicinal materials to fully contact with ethanol. After 72 hours, filter it with filter paper to obtain the emulsion extract.

[0028] Preferably, the crushing of borneol comprises the following steps:

[0029] S1: Use a clean mortar and place the borneol flakes in it;

[0030] S2: Use a pestle to grind the borneol. Keep the mortar and pestle dry to prevent the borneol from absorbing moisture. Grind with moderate force to avoid splashing the borneol.

[0031] S3: Continue grinding until the borneol becomes extremely fine powder. The particle size can be observed under a microscope. When most particles are less than 100 μm in size, they meet the requirements. Weigh their weight, record it as M4, and record it.

[0032] Preferably, the decoction of liquid medicine B comprises the following steps:

[0033] S1: Put the dried herbs in step 1 into a decoction pot, add water according to the total weight of the herbs M1 at a ratio of 1:10, that is, add 10M1 of water, and use a measuring cup to accurately measure;

[0034] S2: Soak the herbs for 2 hours. Stir gently several times during the soaking process to allow the herbs to fully absorb the water. After the soaking is complete, boil the water over high heat.

[0035] S3: After the water boils, turn to low heat and simmer. Use a thermometer to monitor the temperature and keep it between 90℃-100℃. Continue simmering until 1 / 3 of the original volume of the medicinal liquid remains. Then filter it with a filter to obtain medicinal liquid B. Collect the medicinal liquid B in a clean container.

[0036] Preferably, mixing the drug solution B and the drug powder A comprises the following steps:

[0037] S1: Place drug solution B in a clean stirring container, which should be made of stainless steel or glass to avoid chemical reactions with the drug;

[0038] S2: Slowly add powder A into liquid B, stirring with a glass rod at a speed of 30-50 revolutions per minute to ensure that the powder is evenly dispersed in the liquid;

[0039] S3: Continue stirring for about 15-20 minutes to fully mix the liquid medicine B and the powder medicine A to form a uniform mixture C. During the stirring process, pay attention to observe the texture and uniformity of the mixture.

[0040] Preferably, the adding of the emulsion extract comprises the following steps:

[0041] S1: slowly pour the emulsion extract into the mixture C. The pouring speed should not be too fast. You can use a dropper to add it drop by drop or pour it slowly along the wall of the container;

[0042] S2: Use an electric stirrer to stir the mixture C and the emulsion extract at a stirring speed of 60-80 revolutions per minute to ensure that the two are fully mixed;

[0043] S3: Continue stirring for about 20-30 minutes until a uniform mixture D is formed. Observe the color, texture and smell of the mixture to ensure that it is uniform.

[0044] Preferably, the preparation of the plaster comprises the following steps:

[0045] S1: Carefully add the crushed borneol to mixture D and stir gently with a stirring rod. Stir slowly at the beginning to avoid generating too many bubbles.

[0046] S2: gradually increase the stirring speed during stirring to make the borneol evenly dispersed in the mixture D, stirring for about 10-15 minutes;

[0047] S3: Transfer the prepared ointment into a clean, sealed ointment jar and store it in a cool, dry place, away from direct sunlight and high temperature to prevent the ointment from deteriorating.

[0048] The beneficial effects of the present invention are:

[0049] 1. The present invention reduces the use of processed Chuanwu and processed Caowu. These two medicinal materials contain aconitine, which can easily cause adverse reactions such as poisoning if used improperly. The new formula avoids the potential safety hazards caused by the use of medicinal materials containing aconitine, reduces the risk of poisoning caused by drug toxicity when using the ointment, and makes the ointment safer and more reliable during use, and is particularly suitable for patients who use it for a long time or have sensitive skin;

[0050] 2. Adding herbs with wind-removing and dampness-removing effects such as Gentiana macrophylla, Clematis chinensis, Angelica pubescens, and Saposhnikovia divaricata, these herbs work synergistically to more effectively dredge meridians and remove rheumatism. The alkaloid components in Gentiana macrophylla, clematisin in Clematis chinensis, volatile oils in Angelica pubescens, volatile oils in Saposhnikovia divaricata, and other active ingredients can better improve symptoms such as joint pain and poor flexion and extension, and the therapeutic effect on rheumatic arthralgia is significantly enhanced compared to the original formula;

[0051] 3. The dosage of blood-activating and stasis-removing drugs such as Chuanxiong, Achyranthes bidentata, Angelica sinensis, and Salvia miltiorrhiza has been increased. The active ingredients they contain can more significantly promote blood circulation. Ligustrazine in Chuanxiong and ferulic acid in Angelica sinensis can dilate blood vessels, increase local blood flow, accelerate the absorption and dissipation of blood stasis, and have a better effect on improving blood stasis blockage, especially for symptoms such as traumatic injuries, blood stasis and swelling, which can relieve blood stasis symptoms more quickly and promote the recovery of injured tissues;

[0052] 4. Adjust the processing method of frankincense and myrrh, extract their active ingredients through ethanol, and more fully extract the active substances such as terpenoids and volatile oils. These ingredients can more effectively inhibit the release of inflammatory mediators, enhance the analgesic and swelling-reducing ability of the ointment, and can relieve pain and swelling more quickly and effectively, so that the patient's pain can be better relieved and the patient's suffering can be reduced;

[0053] 5. The dosage of safflower, rhubarb and other medicinal materials is adjusted to make the ratio between the medicinal materials more reasonable, enhance the comprehensive efficacy of the whole ointment, and play a better synergistic role, thereby improving the overall effect of dispelling wind and dampness, eliminating blood stasis and swelling, promoting blood circulation and relieving pain. It is more suitable for the treatment of various diseases and can more widely meet the needs of different patients;

[0054] 6. Borneol is ground into extremely fine powder, which enhances its transdermal promoting effect, helps guide other drugs to better penetrate the skin to reach the lesion site, enables the drugs to more fully exert their efficacy, improves the bioavailability of the drugs, and ensures that the efficacy of the drugs is fully exerted. BRIEF DESCRIPTION OF THE DRAWINGS

[0055] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0056] Figure 1 The present invention provides a flow chart of a method for preparing an external ointment for dispelling wind and dampness, eliminating blood stasis and swelling, and promoting blood circulation and relieving pain. DETAILED DESCRIPTION

[0057] The technical solution of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0058] Embodiment 1

[0059] according to Figure 1 As shown, an external ointment for dispelling wind and dampness, eliminating blood stasis and swelling, promoting blood circulation and relieving pain, the external ointment comprises the following raw materials by weight:

[0060] 6 parts of Carthami, 8 parts of Gentiana macrophylla, 8 parts of Clematidis, 6 parts of Angelica dahurica, 6 parts of Saposhnikovia divaricata, 8 parts of Ligusticum chuanxiong, 6 parts of Achyranthes bidentata, 5 parts of Olibanum, 5 parts of Myrrha, 8 parts of Angelica sinensis, 8 parts of Salvia miltiorrhiza, 4 parts of Eupolyphaga sinensis, 5 parts of Rhubarb, 6 parts of Achyranthes bidentata, 4 parts of Curcuma longa, 5 parts of Ophiopogon japonicus, 6 parts of Sparganium wilfordii, 4 parts of Curcuma longa, 3 parts of Borneolum, 7 parts of Chaenomeles sinensis, 4 parts of Cortex Moutan, 4 parts of Asarum.

[0061] It should be noted that: this external ointment selects a variety of Chinese medicinal materials with specific effects, and through reasonable compatibility, exerts a synergistic effect to achieve the effects of dispelling wind and dampness, eliminating blood stasis and swelling, and promoting blood circulation and relieving pain. Medicinal materials such as safflower, chuanxiong, Achyranthes bidentata, angelica, and salvia miltiorrhiza are rich in effective ingredients such as ligustrazine and ferulic acid, which can dilate blood vessels, increase local blood flow, promote blood circulation, accelerate the absorption and dissipation of blood stasis, and achieve the effect of promoting blood circulation; medicinal materials such as gentiana, clematis, angelica pubescens, and saposhnikovia contain active ingredients such as alkaloids and volatile oils, which can dredge meridians, eliminate rheumatism, relieve symptoms such as joint pain and flexion and extension difficulties, and achieve the effect of dispelling wind and dampness; terpenoid compounds and volatile oils obtained after ethanol extraction of frankincense and myrrh can inhibit the release of inflammatory mediators, and cooperate with medicinal materials such as earthworm, rhubarb, and Liujinu to play the role of reducing swelling and relieving pain; borneol is ground into extremely fine powder to enhance the transdermal promotion effect and guide other drugs to reach the lesion through the skin.

[0062] Embodiment 2

[0063] On the basis of Example 1, a method for preparing an external ointment for dispelling wind and dampness, eliminating blood stasis and swelling, and promoting blood circulation and relieving pain is provided, which adopts the external ointment for dispelling wind and dampness, eliminating blood stasis and swelling, and promoting blood circulation and relieving pain of Example 1, comprising the following steps:

[0064] Step 1, washing and drying the medicinal materials: adjust safflower, gentiana macrophylla, clematis root, angelica dahurica, saposhnikovia divaricata, chuanxiong, cyathula officinalis, angelica sinensis, salvia miltiorrhiza, firewood, retain part of the firewood, adjust to 4 parts, wash asarum separately, remove impurities, and then dry these medicinal materials at room temperature, assuming that the total weight of these medicinal materials is M1;

[0065] Step 2, grinding the medicinal materials into fine powder: take Eupolyphaga sinensis, Rhubarb, Achyranthes bidentata, Curcuma longa, Aconiti Lateralis Preparata, Tripterygium wilfordii, Curcuma zedoaria, Vaccaria segetalis, grind them into fine powder, pass through a 100-mesh sieve, and obtain medicinal powder A. Let the total weight of these medicinal materials after grinding be M2;

[0066] Step 3, extracting the active ingredients with ethanol: taking frankincense and myrrh, placing them in a sealed container, adding an appropriate amount of ethanol, soaking for 72 hours, and then filtering to obtain a frankincense extract, wherein the amount of ethanol is 5 times the total weight of the frankincense and myrrh, assuming that the total weight of the frankincense and myrrh is M3, and extracting the active ingredients therein;

[0067] Step 4, grinding borneol: Take borneol and grind it into very fine powder for later use, and set its weight as M4;

[0068] Step 5, decocting liquid medicine B: adding an appropriate amount of water to the dried medicinal materials in step 1, soaking for 2 hours, then boiling over high heat, then decocting over low heat until 1 / 3 of the original volume of the liquid medicine remains, and filtering to obtain liquid medicine B;

[0069] Step 6, mixing the liquid medicine B and the powder medicine A: Mix the liquid medicine B with the powder medicine A, stir evenly, and obtain a mixture C. This step is to fully integrate the water-soluble and powdery medicinal materials to exert a synergistic effect;

[0070] Step 7, adding the emulsion extract: slowly adding the emulsion extract to the mixture C, stirring while adding to ensure uniform mixing, to obtain a mixture D, wherein stirring is used to promote uniform distribution of different active ingredients;

[0071] Step 8, making an ointment: Finally, add the crushed borneol into mixture D, stir evenly, and make an ointment.

[0072] In a specific embodiment, washing and drying the medicinal materials comprises the following steps:

[0073] S1: Place safflower, gentiana macrophylla, clematis root, angelica dahurica, saposhnikovia root, chuanxiong, cyathula, angelica sinensis, salvia miltiorrhiza, radix strychnifoliae, and asarum in different clean containers. Use running water to rinse these herbs. For parts with dirt or a lot of impurities, use a soft brush to gently scrub them to ensure that the impurities on the surface of the herbs are completely removed.

[0074] S2: Drain the rinsed herbs and place them in a clean, well-ventilated place, away from direct sunlight, and let them dry naturally at room temperature. Spread the herbs evenly and turn them over every once in a while to ensure even drying.

[0075] S3: Use a hygrometer to detect the humidity of the medicinal materials. When the humidity of the medicinal materials drops below 10%, it is considered that the drying is completed. Collect the dried medicinal materials together, weigh their total weight and record it as M1, and keep a record.

[0076] It should be noted that when cleaning medicinal materials, for some soft or easily broken medicinal materials, such as safflower, the rinsing time should not be too long to avoid destroying their effective ingredients. In the process of drying the medicinal materials, ventilation and drying equipment can be used to accelerate the drying process, but the temperature must be controlled within an appropriate range, generally not exceeding 40°C, to prevent the medicinal materials from deteriorating due to excessively high temperature. In addition, desiccant can be placed in a dry environment to further reduce the air humidity and speed up the drying process.

[0077] In a specific embodiment, grinding the medicinal material into fine powder comprises the following steps:

[0078] S1: Accurately weigh Eupolyphaga sinensis, Radix Rhei, Rhizoma Cyperi, Rhizoma Curcumae, Rhizoma Aconiti Lateralis, Rhizoma Curcumae, and Rhizoma Vaccariae, using an electronic balance to ensure the accuracy of the weighing, accurate to 0.1g;

[0079] S2: Put the weighed medicinal materials into a mortar, crush them lightly first, and then grind them gradually. You can also use a grinder to grind them. During the grinding process, pay attention to controlling the grinding speed to prevent the medicinal materials from being heated and deteriorating;

[0080] S3: Pass the ground powder through a 100-mesh sieve. If there are coarse particles that do not pass through the sieve, put them back into the mortar or grinder and continue grinding until all of them pass through the sieve to obtain powder A. Weigh the total weight of powder A and record it as M2.

[0081] It should be noted that: in the process of grinding medicinal materials into fine powder, in addition to mortars and grinders, different types of grinding equipment can be selected according to the characteristics of the medicinal materials. For medicinal materials with hard texture, such as Trillium and Curcuma, ball mills can be used for grinding, which can improve grinding efficiency and powder fineness. When using grinding equipment, regular maintenance and cleaning should be carried out to prevent impurities remaining inside the equipment from contaminating the medicinal powder. At the same time, the grinding speed and time should be adjusted according to the properties of the medicinal materials to avoid overheating or over-grinding of the medicinal materials.

[0082] In a specific embodiment, the ethanol extraction of the effective ingredient comprises the following steps:

[0083] S1: Accurately weigh frankincense and myrrh, use an electronic balance to ensure accurate weight, record the total weight as M3, and put them into a clean sealed glass container;

[0084] S2: Calculate the required volume V of ethanol according to the formula V=5M3, measure the corresponding volume of ethanol, use a measuring cylinder to accurately measure, ensure that the amount of ethanol meets the requirements, slowly pour the ethanol into a sealed container, ensure that the frankincense and myrrh are completely immersed in the ethanol, and seal the container;

[0085] S3: Place the sealed container in a cool, dry place, ensure that the ambient temperature is between 20℃-25℃, and let it stand for 72 hours. During this period, shake the container appropriately to allow the medicinal materials to fully contact with ethanol. After 72 hours, filter it with filter paper to obtain the emulsion extract.

[0086] It should be noted that when using ethanol to extract the active ingredients of frankincense and myrrh, the concentration of ethanol can be optimized. By comparing the extraction effects of ethanol of different concentrations, it was found that appropriately increasing the ethanol concentration to 75% can more effectively extract active ingredients such as terpenoids and volatile oils. During the extraction process, ultrasonic-assisted extraction technology can be used to shorten the extraction time and improve the extraction efficiency. At the same time, attention should be paid to the safety of the extraction environment to avoid fire or explosion caused by ethanol volatilization.

[0087] In a specific embodiment, the crushing of borneol comprises the following steps:

[0088] S1: Use a clean mortar and place the borneol flakes in it;

[0089] S2: Use a pestle to grind the borneol. Keep the mortar and pestle dry to prevent the borneol from absorbing moisture. Grind with moderate force to avoid splashing the borneol.

[0090] S3: Continue grinding until the borneol becomes extremely fine powder. The particle size can be observed under a microscope. When most particles are less than 100 μm in size, they meet the requirements. Weigh their weight, record it as M4, and record it.

[0091] It should be noted that when grinding borneol, a small amount of anhydrous ethanol can be added to the mortar, which will help grind the borneol into extremely fine powder faster and reduce the volatilization of borneol. The extremely fine powder of borneol in the ointment can not only play a role in promoting transdermal penetration, but also increase the cooling feeling of the ointment and relieve local pain. In actual application, the amount of borneol can be adjusted according to the patient's skin sensitivity. For patients with more sensitive skin, the amount of borneol should be appropriately reduced to avoid causing skin discomfort.

[0092] In a specific embodiment, decocting the medicinal liquid B comprises the following steps:

[0093] S1: Put the dried herbs in step 1 into a decoction pot, add water according to the total weight of the herbs M1 at a ratio of 1:10, that is, add 10M1 of water, and use a measuring cup to accurately measure;

[0094] S2: Soak the herbs for 2 hours. Stir gently several times during the soaking process to allow the herbs to fully absorb the water. After the soaking is complete, boil the water over high heat.

[0095] S3: After the water boils, turn to low heat and simmer. Use a thermometer to monitor the temperature and keep it between 90℃-100℃. Continue simmering until 1 / 3 of the original volume of the medicinal liquid remains. Then filter it with a filter to obtain medicinal liquid B. Collect the medicinal liquid B in a clean container.

[0096] It should be noted that: when decocting liquid B, the soaking time, decoction temperature and time can be optimized. Through experiments, it is found that for some medicinal materials, appropriately extending the soaking time to 3 hours can enable the medicinal materials to fully absorb water and increase the decoction rate of effective ingredients. During the decoction process, temperature control equipment can be used to accurately control the temperature so that the temperature is stabilized at around 95°C, which can not only ensure the efficacy of the medicine, but also avoid the destruction of effective ingredients caused by excessive decoction. At the same time, attention should be paid to the material selection of the decoction pot, and metal pots should be avoided to avoid chemical reactions with the medicinal materials.

[0097] In a specific embodiment, mixing the drug solution B and the drug powder A comprises the following steps:

[0098] S1: Place drug solution B in a clean stirring container, which should be made of stainless steel or glass to avoid chemical reactions with the drug;

[0099] S2: Slowly add powder A into liquid B, stirring with a glass rod at a speed of 30-50 revolutions per minute to ensure that the powder is evenly dispersed in the liquid;

[0100] S3: Continue stirring for about 15-20 minutes to fully mix the liquid medicine B and the powder medicine A to form a uniform mixture C. During the stirring process, pay attention to observe the texture and uniformity of the mixture.

[0101] It should be noted that: in the process of mixing liquid B and powder A and adding emulsion extract, the control of stirring speed and time has an important influence on the quality of the ointment. A stirring device with adjustable stirring speed can be used to adjust the stirring speed in real time according to the state of the mixture. In the initial stage of stirring, the speed can be slightly slower to avoid flying powder or splashing liquid. As the mixing proceeds, the stirring speed is gradually increased to ensure that all ingredients are fully mixed. The stirring time can be appropriately adjusted according to the uniformity of the mixture, and the mixing effect can be judged by observing indicators such as the color, texture and fluidity of the mixture.

[0102] In a specific embodiment, adding the emulsion extract comprises the following steps:

[0103] S1: slowly pour the emulsion extract into the mixture C. The pouring speed should not be too fast. You can use a dropper to add it drop by drop or pour it slowly along the wall of the container;

[0104] S2: Use an electric stirrer to stir the mixture C and the emulsion extract at a stirring speed of 60-80 revolutions per minute to ensure that the two are fully mixed;

[0105] S3: Continue stirring for about 20-30 minutes until a uniform mixture D is formed. Observe the color, texture and smell of the mixture to ensure that it is uniform.

[0106] In a specific embodiment, making the plaster comprises the following steps:

[0107] S1: Carefully add the crushed borneol to mixture D and stir gently with a stirring rod. Stir slowly at the beginning to avoid generating too many bubbles.

[0108] S2: gradually increase the stirring speed during stirring to make the borneol evenly dispersed in the mixture D, stirring for about 10-15 minutes;

[0109] S3: Transfer the prepared ointment into a clean, sealed ointment jar and store it in a cool, dry place, away from direct sunlight and high temperature to prevent the ointment from deteriorating.

[0110] It should be noted that the prepared ointment should be subjected to stability research to examine the changes in its quality under different storage conditions. The ointment can be placed at room temperature, high temperature (such as 30°C), low temperature (such as 5°C) and light conditions, and the appearance, pH value, active ingredient content and other indicators of the ointment should be tested regularly. According to the results of the stability study, the optimal storage conditions and shelf life of the ointment can be determined. During storage, desiccant can be added to the ointment jar to prevent the ointment from getting damp and deteriorating. At the same time, attention should be paid to the sealing of the ointment jar to prevent air from entering and causing oxidation of the ointment.

[0111] It is further explained that:

[0112] The present invention focuses on the field of external ointment, and focuses on the effects of dispelling wind and dampness, eliminating blood stasis and swelling, and promoting blood circulation and relieving pain. Starting from the raw materials and preparation process, the raw materials are carefully screened and scientifically proportioned, and a systematic and sophisticated process is designed in the preparation process, so as to improve the safety and effectiveness of the ointment;

[0113] Principle of raw material compatibility: The present invention uses a clever combination of medicinal materials to exert synergistic effects. Blood-activating and stasis-removing medicinal materials such as safflower, chuanxiong, Achyranthes bidentata, angelica sinensis, and salvia miltiorrhiza contain ingredients such as ligustrazine and ferulic acid, which can dilate blood vessels, increase blood flow, and accelerate the absorption and dissipation of blood stasis. Wind-removing and dampness-removing medicinal materials such as gentiana macrophylla, clematis root, angelica pubescens, and saposhnikovia divaricata can dredge meridians, dispel rheumatism, and relieve joint pain by virtue of active ingredients such as alkaloids and volatile oils. Terpene compounds and volatile oils extracted from frankincense and myrrh by ethanol are combined with earthworms and rhubarb to exert swelling and analgesic effects. Borneol is ground into extremely fine powder to enhance transdermal permeability and guide the drug directly to the affected area. These medicinal materials cooperate with each other to play a role in all-round symptoms such as rheumatic arthralgia and blood stasis. At the same time, the processed Chuanwu and processed Caowu containing aconitine are discarded, which reduces the safety risk caused by drug toxicity, making the ointment safer and more reliable, and is especially suitable for patients with long-term use or sensitive skin.

[0114] Preparation process principle: Each step of the preparation process is closely linked, fully extracting and integrating the effective ingredients of the medicinal materials, washing and drying to remove impurities and moisture, ensuring the purity of the medicinal materials for subsequent processing, grinding some medicinal materials into fine powder, increasing the contact area, and improving the efficiency of component extraction and integration. Ethanol is used to extract the effective ingredients of frankincense and myrrh, which can fully obtain the active substances and enhance the analgesic and swelling-reducing ability. The medicinal liquid is decocted to extract the water-soluble components, and the various components are mixed and stirred in sequence to promote the full integration of water-soluble, powdery and fat-soluble components to exert a synergistic effect. Specifically, the dried medicinal materials are first decocted into liquid B, which is then mixed with powder A, followed by the addition of frankincense extract, and finally borneol. After sufficient stirring, the ointment is made to ensure that the efficacy of the medicine can be maximized.

[0115] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art can easily think of changes or substitutions within the technical scope disclosed by the present invention, which should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. An external ointment for dispelling wind and dampness, eliminating blood stasis and swelling, promoting blood circulation and relieving pain, characterized in that The topical ointment includes the following raw materials by weight: 6 parts of Carthami, 8 parts of Gentiana macrophylla, 8 parts of Clematidis, 6 parts of Angelica dahurica, 6 parts of Saposhnikovia divaricata, 8 parts of Ligusticum chuanxiong, 6 parts of Achyranthes bidentata, 5 parts of Olibanum, 5 parts of Myrrha, 8 parts of Angelica sinensis, 8 parts of Salvia miltiorrhiza, 4 parts of Eupolyphaga sinensis, 5 parts of Rhubarb, 6 parts of Achyranthes bidentata, 4 parts of Curcuma longa, 5 parts of Ophiopogon japonicus, 6 parts of Sparganium wilfordii, 4 parts of Curcuma longa, 3 parts of Borneolum, 7 parts of Chaenomeles sinensis, 4 parts of Cortex Moutan, 4 parts of Asarum.

2. A method for preparing an external ointment for dispelling wind and dampness, eliminating stasis and swelling, and promoting blood circulation and relieving pain, using the external ointment for dispelling wind and dampness, eliminating stasis and swelling, and promoting blood circulation and relieving pain as claimed in claim 1, characterized in that: The following steps are involved: Step 1, washing and drying the medicinal materials: adjust safflower, gentiana macrophylla, clematis root, angelica dahurica, saposhnikovia divaricata, chuanxiong, cyathula officinalis, angelica sinensis, salvia miltiorrhiza, firewood, retain part of the firewood, adjust to 4 parts, wash asarum separately, remove impurities, and then dry these medicinal materials at room temperature, assuming that the total weight of these medicinal materials is M1; Step 2, grinding the medicinal materials into fine powder: take Eupolyphaga sinensis, Rhubarb, Achyranthes bidentata, Curcuma longa, Aconiti Lateralis Preparata, Tripterygium wilfordii, Curcuma zedoaria, Vaccaria segetalis, grind them into fine powder, pass through a 100-mesh sieve, and obtain medicinal powder A. Let the total weight of these medicinal materials after grinding be M2; Step 3, extracting the active ingredients with ethanol: taking frankincense and myrrh, placing them in a sealed container, adding an appropriate amount of ethanol, soaking for 72 hours, and then filtering to obtain a frankincense extract, wherein the amount of ethanol is 5 times the total weight of the frankincense and myrrh, assuming that the total weight of the frankincense and myrrh is M3, and extracting the active ingredients therein; Step 4, grinding borneol: Take borneol and grind it into very fine powder for later use, and set its weight as M4; Step 5, decocting liquid medicine B: adding an appropriate amount of water to the dried medicinal materials in step 1, soaking for 2 hours, then boiling over high heat, then decocting over low heat until 1 / 3 of the original volume of the liquid medicine remains, and filtering to obtain liquid medicine B; Step 6, mixing the liquid medicine B and the powder medicine A: Mix the liquid medicine B with the powder medicine A, stir evenly, and obtain a mixture C. This step is to fully integrate the water-soluble and powdery medicinal materials to exert a synergistic effect; Step 7, adding the emulsion extract: slowly adding the emulsion extract to the mixture C, stirring while adding to ensure uniform mixing, to obtain a mixture D, wherein stirring is used to promote uniform distribution of different active ingredients; Step 8, making an ointment: Finally, add the crushed borneol into mixture D, stir evenly, and make an ointment.

3. The method for preparing an external ointment for dispelling wind and dampness, eliminating blood stasis and swelling, promoting blood circulation and relieving pain according to claim 2, characterized in that: The cleaning and drying of medicinal materials comprises the following steps: S1: Place safflower, gentiana macrophylla, clematis root, angelica dahurica, saposhnikovia root, chuanxiong, cyathula, angelica sinensis, salvia miltiorrhiza, radix strychnifoliae, and asarum in different clean containers. Use running water to rinse these herbs. For parts with dirt or a lot of impurities, use a soft brush to gently scrub them to ensure that the impurities on the surface of the herbs are completely removed. S2: Drain the rinsed herbs and place them in a clean, well-ventilated place, away from direct sunlight, and let them dry naturally at room temperature. Spread the herbs evenly and turn them over every once in a while to ensure even drying. S3: Use a hygrometer to detect the humidity of the medicinal materials. When the humidity of the medicinal materials drops below 10%, it is considered that the drying is completed. Collect the dried medicinal materials together, weigh their total weight and record it as M1, and keep a record.

4. The method for preparing an external ointment for dispelling wind and dampness, eliminating blood stasis and swelling, promoting blood circulation and relieving pain according to claim 3, characterized in that: The grinding of medicinal materials into fine powder comprises the following steps: S1: Accurately weigh Eupolyphaga sinensis, Radix Rhei, Rhizoma Cyperi, Rhizoma Curcumae, Rhizoma Aconiti Lateralis, Rhizoma Curcumae, and Rhizoma Vaccariae, using an electronic balance to ensure the accuracy of the weighing, accurate to 0.1g; S2: Put the weighed medicinal materials into a mortar, crush them lightly first, and then grind them gradually. You can also use a grinder to grind them. During the grinding process, pay attention to controlling the grinding speed to prevent the medicinal materials from being heated and deteriorating; S3: Pass the ground powder through a 100-mesh sieve. If there are coarse particles that do not pass through the sieve, put them back into the mortar or grinder and continue grinding until all of them pass through the sieve to obtain powder A. Weigh the total weight of powder A and record it as M2.

5. The method for preparing an external ointment for dispelling wind and dampness, eliminating blood stasis and swelling, promoting blood circulation and relieving pain according to claim 4, characterized in that: The ethanol extraction of the effective ingredient comprises the following steps: S1: Accurately weigh frankincense and myrrh, use an electronic balance to ensure accurate weight, record the total weight as M3, and put them into a clean sealed glass container; S2: Calculate the required volume V of ethanol according to the formula V=5M3, measure the corresponding volume of ethanol, use a measuring cylinder to accurately measure, ensure that the amount of ethanol meets the requirements, slowly pour the ethanol into a sealed container, ensure that the frankincense and myrrh are completely immersed in the ethanol, and seal the container; S3: Place the sealed container in a cool, dry place, ensure that the ambient temperature is between 20℃-25℃, and let it stand for 72 hours. During this period, shake the container appropriately to allow the medicinal materials to fully contact with ethanol. After 72 hours, filter it with filter paper to obtain the emulsion extract.

6. The method for preparing an external ointment for dispelling wind and dampness, eliminating blood stasis and swelling, promoting blood circulation and relieving pain according to claim 5, characterized in that: The crushed borneol comprises the following steps: S1: Use a clean mortar and place the borneol flakes in it; S2: Use a pestle to grind the borneol. Keep the mortar and pestle dry to prevent the borneol from absorbing moisture. Grind with moderate force to avoid splashing the borneol. S3: Continue grinding until the borneol becomes extremely fine powder. The particle size can be observed under a microscope. When most particles are less than 100 μm in size, they meet the requirements. Weigh their weight, record it as M4, and record it.

7. The method for preparing an external ointment for dispelling wind and dampness, eliminating blood stasis and swelling, promoting blood circulation and relieving pain according to claim 6, characterized in that: The decoction of the medicinal liquid B comprises the following steps: S1: Put the dried herbs in step 1 into a decoction pot, add water according to the total weight of the herbs M1 at a ratio of 1:10, that is, add 10M1 of water, and use a measuring cup to accurately measure; S2: Soak the herbs for 2 hours. Stir gently several times during the soaking process to allow the herbs to fully absorb the water. After the soaking is complete, boil the water over high heat. S3: After the water boils, turn to low heat and simmer. Use a thermometer to monitor the temperature and keep it between 90℃-100℃. Continue simmering until 1 / 3 of the original volume of the medicinal liquid remains. Then filter it with a filter to obtain medicinal liquid B. Collect the medicinal liquid B in a clean container.

8. The method for preparing an external ointment for dispelling wind and dampness, eliminating blood stasis and swelling, promoting blood circulation and relieving pain according to claim 7, characterized in that: Mixing liquid medicine B and powder medicine A includes the following steps: S1: Place drug solution B in a clean stirring container, which should be made of stainless steel or glass to avoid chemical reactions with the drug; S2: Slowly add powder A into liquid B, stirring with a glass rod at a speed of 30-50 revolutions per minute to ensure that the powder is evenly dispersed in the liquid; S3: Continue stirring for about 15-20 minutes to fully mix the liquid medicine B and the powder medicine A to form a uniform mixture C. During the stirring process, pay attention to observe the texture and uniformity of the mixture.

9. The method for preparing an external ointment for dispelling wind and dampness, eliminating blood stasis and swelling, promoting blood circulation and relieving pain according to claim 8, characterized in that: The adding of the emulsion extract comprises the following steps: S1: slowly pour the emulsion extract into the mixture C. The pouring speed should not be too fast. You can use a dropper to add it drop by drop or pour it slowly along the wall of the container; S2: Use an electric stirrer to stir the mixture C and the emulsion extract at a stirring speed of 60-80 revolutions per minute to ensure that the two are fully mixed; S3: Continue stirring for about 20-30 minutes until a uniform mixture D is formed. Observe the color, texture and smell of the mixture to ensure that it is uniform.

10. The method for preparing an external ointment for dispelling wind and dampness, eliminating blood stasis and swelling, promoting blood circulation and relieving pain according to claim 9, characterized in that: The plaster preparation comprises the following steps: S1: Carefully add the crushed borneol to mixture D and stir gently with a stirring rod. Stir slowly at the beginning to avoid generating too many bubbles. S2: gradually increase the stirring speed during stirring to make the borneol evenly dispersed in the mixture D, stirring for about 10-15 minutes; S3: Transfer the prepared ointment into a clean, sealed ointment jar and store it in a cool, dry place, away from direct sunlight and high temperature to prevent the ointment from deteriorating.

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