Artificial remolded omentum majus

Abstract

The invention discloses an artificial remolded omentum majus which comprises a combination of an acellular matrix and a bioabsorbable polymer or a combination of an acellular matrix and a modified polyester material or a combination of an acellular matrix and modified polyether-ether-ketone, the mass ratio of the acellular matrix to the bioabsorbable polymer is 1: (1-3); the mass ratio of the acellular matrix to the modified polyester material is 1: (1-4); the mass ratio of the acellular matrix to the modified polyether-ether-ketone is 1: (1-4). According to the material, tissue regeneration and remodeling are accelerated, the integration degree of the artificial omentum majus and surrounding tissues is improved, the synthetic material provides long-term structural support, the biocompatibility is improved, and the risk of immunological rejection is reduced; the replacement of a fat storage function is realized to a certain extent.

Description

Technical Field

[0001] The invention relates to the field of biotechnology, and in particular to an artificial remodeling method of the greater omentum. Background Art

[0002] The greater omentum is a layer of mucous membrane in the abdominal cavity of higher vertebrates. It is mainly composed of mesothelial cells. It is a membranous tissue formed by the support of connective tissue. It is a layer of peritoneal folds covering the surface of abdominal organs. It covers most of the organs in the abdominal cavity and can secrete mucus to moisten the surface of the organs and reduce the friction between the organs. It has many important physiological functions: for example, when inflammation occurs in the abdominal cavity, it can quickly move to the site of inflammation, wrap the inflammatory lesions, prevent the spread of inflammation, and play a natural defense role. At the same time, the greater omentum is also involved in fat storage, intra-abdominal absorption, and lymphatic drainage. In surgical operations, the greater omentum may be defective or damaged due to trauma, tumor resection, or certain congenital diseases. For example, in abdominal tumor surgeries such as radical gastrectomy, in order to completely remove tumor tissue, it is often necessary to remove part or all of the greater omentum.

[0003] In response to the above technical problems, China's authorized invention patent CN104771788B discloses a tissue-engineered skin based on a decellularized matrix of the greater omentum and a construction method thereof. The construction method of the tissue-engineered skin comprises the following steps: (1) preparing a decellularized matrix scaffold material of the greater omentum, which comprises the step of soaking the greater omentum in a buffer solution containing sodium dodecyl sulfate and DNA enzyme for decellularization; and (2) constructing and culturing the tissue-engineered skin. The tissue-engineered skin obtained by the method is also provided. Since the decellularized matrix of the greater omentum is rich in angiogenic growth factors, it can promote the growth of capillaries from the wound surface into the transplanted tissue-engineered skin, thereby facilitating the vascularization of the tissue-engineered skin and wound healing, which is of great significance to the clinical application of the tissue-engineered skin.

[0004] In addition, China's authorized invention patent CN118370871B discloses a method for preparing a decellularized biological omentum and a decellularized biological omentum prepared therefrom, which includes the following steps: 1) taking fresh omentum tissue for degreasing; 2) oscillating and soaking the fat-removed omentum tissue in decellularization solution I for treatment; 3) treating the omentum tissue treated with decellularization solution I in decellularization solution II; 4) treating the omentum tissue treated with decellularization solution II in decellularization solution III; 5) sterilizing the omentum tissue treated with decellularization solution III after freeze drying. The method of the present invention is simpler to operate and has a shorter cycle. By using decellularization solutions I, II and III of specific formulas at the same time, the DNA content in the decellularized omentum is lower.

[0005] The above patents are all about improving the exogenous decellularized biological omentum as an implant material to promote the restoration of normal physiological functions of the abdominal cavity and reduce postoperative complications such as adhesion formation and spread of infection, which requires artificial remodeling of the greater omentum. Summary of the invention

[0006] The present invention provides an artificial remodeling method of the greater omentum for the case of defect or damage of the greater omentum, which aims to restore the normal physiological function of the abdominal cavity and reduce postoperative complications such as adhesion formation and infection spread.

[0007] In order to achieve the above object, the present invention adopts the following technical solutions:

[0008] In one aspect of the present invention, an artificial remodeling of the greater omentum is provided, comprising a combination of a decellularized matrix and a bioabsorbable polymer, a combination of a decellularized matrix and a modified polyester material, or a combination of a decellularized matrix and a modified polyetheretherketone; the mass ratio of the decellularized matrix and the bioabsorbable polymer is 1:1-3; the mass ratio of the decellularized matrix and the modified polyester material is 1:1-4; the mass ratio of the decellularized matrix and the modified polyetheretherketone is 1:1-4.

[0009] Preferably, the bioabsorbable polymer is any one of a mesh or flocculent form of poly(lactic acid-co-glycolic acid) copolymer.

[0010] Preferably, the polyester material is modified polyethylene terephthalate; the modified polyethylene terephthalate is modified with a material having biological activity; the material having biological activity uses an active short peptide as a biologically active grafted group.

[0011] Preferably, the modified polyetheretherketone is modified using composite bioactive ceramics.

[0012] Preferably, the decellularized matrix is ​​an extracellular matrix scaffold, which is weaved or injection molded with the bioabsorbable polymer to form a reticular structure; the decellularized matrix and modified polyester material are weaved or injection molded to form a reticular structure; the decellularized matrix and modified polyetheretherketone are weaved or injection molded to form a reticular structure.

[0013] Another aspect of the present invention provides an application of an artificially reshaped greater omentum, and the application of the artificially reshaped greater omentum for transplantation in surgical operations.

[0014] Preferably, the transplant is carried out in an allogeneic organism, an allogeneic organism cultured transplant or an allogeneic organism cultured transplant.

[0015] Preferably, the transplant is axillary or other lymphatic transplant, and the greater omentum native carrier is cultivated.

[0016] In order to solve the problem of restoring abdominal cavity function after defect or damage of the greater omentum, the present invention artificially reshapes the greater omentum, uses existing decellularized matrix from animals such as pigs, sheep and cattle, and reshapes it with biological materials or synthetic materials, and then implants it into the human body, which can restore the important physiological functions of the human body such as defense against the spread of inflammation, participation in fat storage and lymphatic drainage, etc. The material is subjected to the effects of skeleton cultivation, differentiation, regeneration and fusion.

[0017] The present invention provides remodeling of the decellularized matrix and biological materials or the decellularized matrix and synthetic materials, proposes a variety of optional materials, and provides flexible options for remodeling the greater omentum under different circumstances according to the characteristics, application methods and scopes of various materials.

[0018] The present invention combines the principles of tissue engineering and promotes the fusion and functional recovery of the artificial greater omentum and human tissue through the comprehensive application of scaffold materials, cells and growth factors.

[0019] The present invention innovatively simulates the physical barrier function of the greater omentum and achieves functional replacement to a certain extent, such as guiding the flow of lymph through specific structural design.

[0020] The present invention combines PLGA with acellular matrix scaffold materials to form a porous structure. PLGA provides mechanical support, and the acellular matrix scaffold can absorb and slowly release lymph fluid to simulate lymphatic drainage function. At the same time, the structure also provides a suitable environment for the attachment and growth of fat cells.

[0021] In summary, since the present invention adopts the above technical solution, the present invention has the following technical effects:

[0022] 1. Remodeling of decellularized matrix with biomaterials or decellularized matrix with synthetic materials provides a variety of material options. The remodeled materials are similar to the microenvironment of the natural greater omentum, which is conducive to cell adhesion, proliferation and differentiation, adapting to the needs of different patients and surgeries, effectively preventing the spread of inflammation and reducing postoperative complications.

[0023] 2. The material of the present invention promotes the vascularization process of the artificial greater omentum, improves the blood supply of the tissue, and the biomaterial has good biocompatibility, which is beneficial to tissue regeneration and functional recovery.

[0024] 3. The material of the present invention accelerates tissue regeneration and remodeling, improves the integration of the artificial greater omentum with surrounding tissues, and the synthetic material provides long-term structural support, improves biocompatibility, and reduces the risk of immune rejection; it achieves the replacement of fat storage function to a certain extent.

[0025] 4. By simulating the structure and function of the natural greater omentum, functional replacement is better achieved. Through special structural design, the lymphatic drainage function is partially simulated, and the absorbable material degrades over time to avoid long-term retention of foreign matter.

[0026] 5. The combined application of different materials can achieve multiple goals such as physical barrier, tissue regeneration and functional replacement, reduce the risk of abdominal adhesion, help maintain the normal function of intra-abdominal organs, improve the stability of the intra-abdominal environment after surgery, and promote patient recovery. DETAILED DESCRIPTION

[0027] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, preferred embodiments are given below to further describe the present invention in detail. However, it should be noted that many details listed in the specification are only for the purpose of enabling the reader to have a thorough understanding of one or more aspects of the present invention, and these aspects of the present invention can be implemented even without these specific details.

[0028] The present invention provides an artificially reshaped greater omentum, comprising a combination of a decellularized matrix and a bioabsorbable polymer, a combination of a decellularized matrix and a modified polyester material, or a combination of a decellularized matrix and a modified polyetheretherketone; the mass ratio of the decellularized matrix to the bioabsorbable polymer is 1:1-3; the mass ratio of the decellularized matrix to the modified polyester material is 1:1-4; the mass ratio of the decellularized matrix to the modified polyetheretherketone is 1:1-4.

[0029] Decellularized matrix is ​​extracted from the omentum or other tissues of animals such as pigs, cattle, and sheep. This material retains the extracellular matrix components of natural tissues, such as collagen, elastic fibers, etc., and has good biocompatibility. For example, through a series of physical and chemical treatment methods, the cell components in the omentum of animals are removed, leaving only the extracellular matrix scaffold.

[0030] In one embodiment, the bioabsorbable polymer is any one of a mesh or flocculent form of poly(lactic acid-co-glycolic acid) copolymer. The mass ratio of the decellularized matrix to the poly(lactic acid-co-glycolic acid) copolymer is 1:1, 1:2 or 1:3.

[0031] Bioresorbable polymers such as polylactic-co-glycolic acid (PLGA) can gradually degrade and be absorbed in the body. In the early stages of omentum remodeling, these polymers can provide certain structural support. Over time, they are absorbed by the human body, and human tissues gradually regenerate to replace their functions. They are made into a shape similar to the omentum through weaving, injection molding, etc. with decellularized matrices and then implanted into the human body.

[0032] In one embodiment, the polyester material is modified polyethylene terephthalate; the modified polyethylene terephthalate is modified with a bioactive material; the bioactive material uses an active short peptide as a bioactive grafting group, and polyethylene terephthalate (PET) has high strength and toughness, and is made into a mesh structure with a suitable porosity, which is used to make the greater omentum with the decellularized matrix. Polyethylene terephthalate is modified with active short peptides to reduce the body's immune response to polyethylene terephthalate. The mass ratio of the decellularized matrix to the modified polyester material is 1:1, 1:2, 1:3 or 1:4.

[0033] In one embodiment, the polyester material is modified polyethylene terephthalate; the modified polyethylene terephthalate is modified with a material having biological activity; the material having biological activity has an active short peptide as a biologically active grafted group.

[0034] In one embodiment, the modified polyetheretherketone is modified by composite bioactive ceramics. Polyetheretherketone (PEEK) is a high-performance thermoplastic material with good mechanical properties and chemical stability. It is processed with acellular matrix to form a suitable shape and structure. The biocompatibility problem is solved by composite bioactive ceramics to improve its interaction with human tissue. The mass ratio of the acellular matrix to the modified polyetheretherketone is 1:1, 1:2, 1:3 or 1:4.

[0035] In one embodiment, the decellularized matrix is ​​an extracellular matrix scaffold, which is formed into a mesh-like structure with the bioabsorbable polymer by weaving or injection molding; the decellularized matrix and modified polyester material are formed into a mesh-like structure by weaving or injection molding; the decellularized matrix and modified polyetheretherketone are formed into a mesh-like structure by weaving or injection molding.

[0036] Provided is an application of an artificially reshaped greater omentum, and an application of the artificially reshaped greater omentum for transplantation in surgical operations.

[0037] In one embodiment, the transplant is an allogeneic transplant, an allogeneic culture transplant, or an allogeneic xenograft transplant.

[0038] In one embodiment, the transplant is an axillary or other lymphatic transplant, cultured as an omentum native carrier.

[0039] In the specific implementation of implanting the greater omentum material, the following steps need to be considered:

[0040] 1. Material selection: The present invention proposes a variety of materials that can be used for artificial omentum remodeling, including biological materials (such as decellularized matrix materials and bioabsorbable polymers) and synthetic materials (such as decellularized matrix materials and polyester materials, decellularized matrix materials and polyetheretherketone).

[0041] 2. Preoperative planning: This includes a comprehensive assessment of the patient, determining the extent and range of the greater omentum defect through imaging examinations, and selecting appropriate materials accordingly.

[0042] 3. Surgical operation: including anesthesia, incision, cleaning and preparation, and implantation of materials.

[0043] 4. Application of tissue engineering principles: Use scaffold materials to provide a growth environment for cells, and may introduce related cells and growth factors to enhance function.

[0044] 5. Physical barrier and functional replacement: The artificial omentum plays a physical barrier role through its structure and replaces the function of the natural omentum to a certain extent.

[0045] Example 1

[0046] Extraction of decellularized matrix material:

[0047] After a series of treatments, the animal greater omentum is removed of cellular components and the extracellular matrix scaffold is retained. The treated material is implanted into the human body, where the body's own cells can migrate and proliferate on the scaffold, gradually forming a tissue similar to the natural greater omentum.

[0048] The extracted cell matrix and PLGA are made into a shape similar to the greater omentum through weaving or injection molding. After implantation into the human body, PLGA gradually degrades in the body, while human tissue gradually regenerates to replace its function.

[0049] Example 2

[0050] After a series of treatments, the animal greater omentum is removed of cellular components and the extracellular matrix scaffold is retained. The treated material is implanted into the human body, where the body's own cells can migrate and proliferate on the scaffold, gradually forming a tissue similar to the natural greater omentum.

[0051] The extracellular matrix scaffold and PET are processed into a mesh structure with appropriate porosity. Before implantation, the PET surface is modified, such as coating with bioactive substances. During implantation, the porosity is adjusted so that it can fully contact with the tissue fluid and cells in the peritoneal cavity.

[0052] Example 3

[0053] After a series of treatments, the animal greater omentum is removed of cellular components and the extracellular matrix scaffold is retained. The treated material is implanted into the human body, where the body's own cells can migrate and proliferate on the scaffold, gradually forming a tissue similar to the natural greater omentum.

[0054] The extracellular matrix scaffold and polyetheretherketone (PEEK) are processed into a mesh structure with appropriate porosity. Before implantation, the PET surface is modified, such as composite bioactive ceramics. During implantation, the porosity is adjusted to allow sufficient contact with the tissue fluid and cells in the peritoneal cavity, while avoiding adhesion caused by tissue embedding in the pores.

[0055] Principles of tissue engineering

[0056] Function of stent material:

[0057] Artificial omentum usually uses suitable scaffold materials, which can provide support for cell adhesion, proliferation and differentiation. For example, acellular matrix materials contain components such as collagen, and the extracellular matrix components can simulate the microenvironment of natural tissues. When the scaffold material is implanted in the body, the body's own cells (such as fibroblasts, endothelial cells, etc.) can recognize and adhere to the scaffold. Just like seeds need soil to grow, these cells rely on the scaffold and begin to grow and reproduce on it.

[0058] The porosity and three-dimensional structure of the scaffold material are also critical. Appropriate porosity allows the exchange of nutrients, oxygen and metabolic waste. Taking polylactic acid-co-glycolic acid (PLGA) as an example, the scaffold made from it has a certain pore structure, cells can grow in the pores, and the metabolic products produced by the cells can be discharged into the surrounding tissue fluid through the pores, while nutrients in the blood can also enter the pores to nourish the cells.

[0059] Cellular involvement:

[0060] In the construction of an ideal artificial omentum, in addition to the physical support provided by the scaffold material, relevant cells will also be introduced to enhance its function. For example, in the laboratory research stage, endothelial cells can be planted on the scaffold material, and the endothelial cells can form a structure similar to the vascular endothelium on the surface of the scaffold, which helps to improve the blood perfusion of the artificial omentum. When implanted in the body, these cells can further differentiate and proliferate, promote the vascularization of the tissue, enable the artificial omentum to better integrate with the surrounding tissue, and play a function similar to that of the natural omentum.

[0061] Application of growth factors:

[0062] Growth factors also play an important role in the principle of artificial omentum. Some growth factors can promote cell proliferation and differentiation. For example, vascular endothelial growth factor (VEGF) can stimulate the proliferation and migration of endothelial cells and induce the formation of new blood vessels. When constructing artificial omentum, growth factors such as VEGF can be combined with scaffold materials, or sustained release technology can be used to continuously release them in vivo to accelerate tissue regeneration and vascularization.

[0063] Physical barriers and functional substitution principles

[0064] Physical barrier function:

[0065] The natural omentum acts as a physical barrier in the abdominal cavity, preventing the spread of inflammation and intestinal adhesions. The artificial omentum can also use its structure to play this role. For example, the mesh artificial omentum made of polyester materials (such as polyethylene terephthalate, PET) can isolate different tissues and organs in the abdominal cavity with its mesh structure, preventing the rapid spread of inflammatory factors. When inflammation occurs in a certain part of the abdominal cavity, the artificial omentum can wrap the inflammatory lesion like the natural omentum, reducing the damage of inflammation to surrounding tissues.

[0066] Functional replacement:

[0067] Although the artificial greater omentum cannot completely replicate all the functions of the natural greater omentum, it can partially replace its functions. In terms of fat storage, although the artificial material itself may not have the fat storage function, if the artificial greater omentum can be well integrated with the surrounding tissues, the body's own fat cells may be distributed near it, thus achieving the fat storage function to a certain extent.

[0068] In terms of lymphatic drainage function, it is possible to guide the flow of lymph by constructing an artificial omentum with appropriate porosity and fiber structure. For example, by utilizing the fiber arrangement direction and pore structure of the material, lymph can flow along a certain path, simulating the lymphatic drainage path of the natural omentum and promoting the circulation of lymph in the abdominal cavity.

[0069] Working process: After implantation, the outer layer of PLGA material begins to slowly degrade, releasing anti-inflammatory drugs and anti-adhesion factors to inhibit early inflammatory reactions and adhesion formation. As the patient's weight changes, the inner layer of polyurethane material can expand and contract accordingly to maintain appropriate tension. The surface-modified cell adhesion peptide promotes endothelial cell growth, accelerates vascularization and tissue reconstruction. Over time, the PLGA layer is completely degraded, and the new tissue gradually replaces the artificial material, eventually forming a functional new greater omentum tissue.

[0070] Omentum reconstruction after omentectomy in cancer patients. In this case, there is a specific technical problem: cancer patients are often immunocompromised and may also need to receive chemotherapy, which can seriously affect the effectiveness of tissue engineering methods, especially cell survival and function.

[0071] (1) Cell source optimization: Use the patient's own mesenchymal stem cells (MSCs) as seed cells. MSCs have multidirectional differentiation potential and immunomodulatory effects, and are more suitable for patients with low immune function. At the same time, MSCs are pretreated during the in vitro culture stage, such as hypoxic pre-adaptation and antioxidant factor (such as N-acetylcysteine) treatment, to improve their survival ability in harsh environments.

[0072] (2) Improvement of scaffold materials: Design a microsphere composite scaffold with a core-shell structure. The microsphere core contains sustained-release growth factors (such as VEGF and basic fibroblast growth factor bFGF), and the shell is made of degradable chitosan material. This design can protect the growth factors from the effects of chemotherapy drugs while achieving sustained and stable release.

[0073] (3) Microenvironment regulation: A responsive hydrogel system is introduced into the scaffold material. This system can sense the pH changes of the local microenvironment (the tumor microenvironment is usually acidic) and release alkaline substances or antioxidants accordingly to maintain the appropriate microenvironment pH and redox state.

[0074] (4) Functional zoning design: The scaffold material is divided into different functional areas. The central area is rich in factors that promote angiogenesis, while the peripheral area is rich in factors that promote lymphangiogenesis (such as VEGF-C). This design can better simulate the structure and function of the natural greater omentum.

[0075] Working process: First, MSCs are isolated and expanded from the patient's body, and pretreated to enhance their survival ability. Then, the pretreated MSCs are inoculated onto the functionally partitioned microsphere composite scaffold. After implantation into the patient's body, the growth factors in the scaffold material begin to be slowly released, promoting the proliferation and differentiation of MSCs. The responsive hydrogel system continuously monitors and regulates the local microenvironment to provide optimal conditions for cell growth. Over time, different functional areas gradually form vascular and lymphatic networks, and eventually construct a new greater omentum tissue with complete functions.

[0076] Application scenario: Preventive omentum reconstruction for patients at high risk of abdominal infection (such as after open abdominal trauma or complex abdominal surgery). In this case, there is a specific technical problem: it is necessary to achieve active antibacterial function and dynamically regulated inflammation control capabilities while providing an effective physical barrier, while also considering that different parts may require different degrees of barrier function.

[0077] (1) Multi-layer barrier structure: A three-layer composite structure of artificial omentum is designed. The outermost layer is a nanofiber membrane with adjustable pore size, which can be customized according to the needs of different parts; the middle layer is a hydrogel layer rich in antimicrobial peptides and anti-inflammatory factors; the inner layer is a porous elastomer that simulates the mechanical properties of the natural omentum.

[0078] (2) Intelligent antibacterial system: pH-sensitive microcapsules containing broad-spectrum antibiotics are embedded in the nanofiber membrane. When the local environmental pH decreases (usually indicating bacterial infection), the microcapsules rupture and release antibiotics, achieving targeted antibacterial effects.

[0079] (3) Dynamic inflammation regulation: A temperature-responsive polymer (such as poly (N-isopropylacrylamide)) is introduced into the hydrogel layer. When the temperature rises due to inflammation, the polymer undergoes a phase change and releases the anti-inflammatory factors (such as interleukin-10) encapsulated therein.

[0080] (4) Functional gradient design: Through 3D printing technology, a functional gradient structure is created in the porous elastomer layer. The area close to the vital organs has higher porosity and softer mechanical properties, which is conducive to organ activity; the area away from the vital organs has lower porosity and higher strength, providing a stronger physical barrier effect.

[0081] (5) Biosensor and feedback system: Micro biosensors are embedded in the hydrogel layer to monitor the pH, temperature, bacterial metabolites and other indicators of the local environment in real time. The sensor data is sent to the in vitro monitoring device through wireless transmission. Doctors can evaluate the infection and inflammation status based on this data and trigger the drug release system in the artificial omentum through external stimulation (such as light of a specific wavelength) to achieve precise treatment.

[0082] Working process: After implantation, the multi-layered structure provides comprehensive protection for the abdominal cavity. When local infection occurs, pH changes trigger the release of antibiotics; the temperature increase caused by inflammation leads to the release of anti-inflammatory factors. The functional gradient design ensures that different areas receive appropriate barrier protection. At the same time, the biosensor system continuously monitors the local environment and provides doctors with real-time data, so that the treatment plan can be dynamically adjusted according to the patient's condition. This intelligent and personalized design greatly improves the prevention and treatment effects of the artificial greater omentum and provides a safer and more effective solution for high-risk patients.

[0083] The material of the present invention is suitable for people with a BMI index between 18 and 27, but is not suitable for reshaping the greater omentum after laparoscopic weight loss surgery in obese patients. Since obese patients have a high intra-abdominal fat content, they are prone to severe adhesions and inflammatory reactions after surgery. At the same time, the impact of the patient's weight change after surgery on the artificial greater omentum needs to be considered.

[0084] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. An artificial remodeling of the greater omentum, characterized in that: It includes a combination of a decellularized matrix and a bioabsorbable polymer, a combination of a decellularized matrix and a modified polyester material, or a combination of a decellularized matrix and a modified polyetheretherketone; the mass ratio of the decellularized matrix and the bioabsorbable polymer is 1:1-3; the mass ratio of the decellularized matrix and the modified polyester material is 1:1-4; the mass ratio of the decellularized matrix and the modified polyetheretherketone is 1:1-4.

2. The method for artificially remodeling the greater omentum according to claim 1, characterized in that: The bioabsorbable polymer is any one of a mesh or flocculent form of poly(lactic acid-co-glycolic acid) copolymer.

3. The method for artificially remodeling the greater omentum according to claim 1, characterized in that: The polyester material is modified polyethylene terephthalate; the modified polyethylene terephthalate is modified by using a material having biological activity; the material having biological activity uses an active short peptide as a biologically active grafting group.

4. The method for artificially remodeling the greater omentum according to claim 1, characterized in that: The modified polyester material is modified by using active short peptides.

5. The method for artificially remodeling the greater omentum according to claim 1, characterized in that: The modified polyetheretherketone is modified by composite bioactive ceramics.

6. The method for artificially remodeling the greater omentum according to claim 1, characterized in that: The decellularized matrix is ​​an extracellular matrix scaffold, and forms a mesh-like structure with the bioabsorbable polymer by weaving or injection molding; the decellularized matrix and modified polyester material form a mesh-like structure by weaving or injection molding; the decellularized matrix and modified polyetheretherketone form a mesh-like structure by weaving or injection molding.

7. A use of the method for artificially remodeling the greater omentum as claimed in claim 1, characterized in that: The artificially reshaped greater omentum is used for transplantation in surgical operations.

8. The use according to claim 7, characterized in that: In allogeneic biological transplantation, allogeneic biological cultivation transplantation, or autologous biological cultivation transplantation at different sites.

9. The use according to claim 8, characterized in that: The transplantation is axillary or other lymphatic transplantation, and the greater omentum native carrier is cultivated.