Integrated production equipment for pharmaceutical industry and use method

Abstract

The invention discloses integrated production equipment for the pharmaceutical industry and a using method, and belongs to the technical field of medicines.The integrated production equipment comprises a damping rack and a pharmaceutical tank body fixedly installed on the damping rack, and a stirring and mixing assembly is installed on the pharmaceutical tank body. Through the designed convection assembly, the mixed material stream flowing in or out through the drainage valve pipe can vertically act on the vortex generated by the stirring blades and the cutting wheel ring, so that the flowing track of the mixed material in the pharmaceutical tank body can be further increased, stirring is assisted, the stirring speed is increased, and the stirring effect is further improved; by means of the technical scheme, the influence capacity on the mixture near the inner wall of the pharmaceutical tank body can be enhanced to a high degree, on one hand, the reaction uniformity of the mixture can be improved, the situation that the mixture near the inner wall of the pharmaceutical tank body slowly flows or stays still, and consequently the heat transfer or heat dissipation effect is affected can be avoided, meanwhile, scaling can be avoided, and the service life of the pharmaceutical tank body is prolonged. And the heating device always has a better heat transfer effect.

Description

Technical Field

[0001] The present invention belongs to the field of medical technology, and in particular relates to an integrated production device for the pharmaceutical industry and a use method thereof. Background Art

[0002] Biological drugs refer to a type of products used for prevention, treatment and diagnosis that are manufactured from organisms, biological tissues, cells, organs, body fluids, etc. using the research results of microbiology, biology, medicine, biochemistry, etc., and comprehensively utilizing the scientific principles and methods of microbiology, chemistry, biochemistry, biotechnology, pharmacy, etc.

[0003] Some invention patents in the field of medical technology are disclosed in the prior art. Among them, the invention patent with application number CN202110364857.1 discloses a stirring device for biopharmaceuticals. The technical problem solved by this patent is that most of the existing stirring equipment uses a stirring piece for long-term continuous stirring and mixing, and no agitation impact can be formed between the raw materials, resulting in low mixing efficiency of the equipment, long time consumption, and poor mixing uniformity between the raw materials, which greatly reduces the normal use effect of subsequent biopharmaceuticals. The patent has solved the above problems through the mutual cooperation of designed driven gears, connecting plates, support columns, curved blades and other structures.

[0004] There are still some shortcomings in the use of existing biopharmaceutical mixing equipment. In order to improve the synthesis efficiency of medical drugs in the mixing equipment, a mechanical stirring mechanism is usually added to the mixing equipment. In order to reduce the resistance of the mechanical stirring mechanism and also to improve the stability of the reactor, the working coverage of the added mechanical stirring mechanism is much smaller than the inner diameter of the reactor, resulting in a slow mixing flow rate of the pharmaceutical raw materials flowing near the wall of the mixing equipment, which seriously affects the preparation efficiency of the mixing equipment and the product quality. In addition, due to the certain direction of the mechanical stirring mechanism, the flow direction of the mixture in the reactor is single, which is prone to stratification.

[0005] Based on this, the present invention designs an integrated production equipment and a method of use for the pharmaceutical industry to solve the above problems. Summary of the invention

[0006] The purpose of the present invention is to solve some shortcomings of existing biopharmaceutical mixing equipment during use. In order to improve the synthesis efficiency of medical drugs in the mixing equipment, a mechanical stirring mechanism is usually added in the mixing equipment. In order to reduce the resistance of the mechanical stirring mechanism and also to improve the stability of the reactor, the working coverage of the added mechanical stirring mechanism is much smaller than the inner diameter of the reactor, resulting in a slow mixing flow rate of the pharmaceutical raw materials flowing near the wall of the mixing equipment, seriously affecting the preparation efficiency and product quality of the mixing equipment. In addition, due to the certain steering direction of the mechanical stirring mechanism, the mixed material has a single flow direction in the reactor, which is prone to the undesirable phenomenon of stratification. Therefore, an integrated production equipment for the pharmaceutical industry and a method of use are proposed.

[0007] In order to achieve the above object, the present invention adopts the following technical solutions:

[0008] An integrated production device for the pharmaceutical industry and a method of using the same, comprising a shock-absorbing frame and a pharmaceutical tank body fixedly mounted on the shock-absorbing frame, a stirring and mixing assembly mounted on the pharmaceutical tank body, and a convection assembly fixedly connected to a position inside the pharmaceutical tank body corresponding to the stirring and mixing assembly, and a flow control assembly is also arranged on the surface of the stirring and mixing assembly at a position corresponding to the convection assembly;

[0009] The convection component includes a sliding connecting sleeve, which is slidably sleeved on the surface of the driven stirring main shaft, and a sealed piston disk is fixedly sleeved on the outer arc surface of the sliding connecting sleeve, and a plurality of wedge-shaped seats are fixedly connected to the top of the sealed piston disk in an annular array, and a power conversion device is fixedly connected above the wedge-shaped seat, and the end of the power conversion device away from the wedge-shaped seat is fixedly connected to the surface of the driven stirring main shaft.

[0010] As a further description of the above technical solution:

[0011] The stirring and mixing assembly includes a driven stirring spindle, which is rotatably connected to the top of the inner side of the pharmaceutical tank body, and a plurality of through-connection holes are opened on the surface of the driven stirring spindle at positions corresponding to the inner side of the pharmaceutical tank body, and a switching sleeve is fixedly sleeved on the surface of the driven stirring spindle at positions corresponding to the through-connection holes, and a plurality of stirring blades are clamped on the outer arc surface of the switching sleeve, and a cutting wheel ring is connected to the end of the stirring blade away from the switching sleeve.

[0012] As a further description of the above technical solution:

[0013] The top end of the driven stirring main shaft is fixedly connected to the output shaft of the electric motor, the surface of the electric motor body is fixedly connected to the top of the pharmaceutical tank body through a frame, and the positions of the multiple through-connection holes are set according to the internal structure of the pharmaceutical tank body.

[0014] As a further description of the above technical solution:

[0015] A ventilation pipe is also clamped on the surface of the driven stirring main shaft, and a gas-liquid separation membrane is embedded and connected in a port of the ventilation pipe away from one end of the driven stirring main shaft.

[0016] As a further description of the above technical solution:

[0017] A first sliding connection groove is opened on the inner wall of the pharmaceutical tank body at a position corresponding to the sealed piston disk, a first sliding connection seat is slidably connected in the first sliding connection groove, the first sliding connection seat and the opposite surface of the sealed piston disk are fixedly connected, and a first supporting spring is embeddedly connected at a position corresponding to the first sliding connection seat on the inner side of the first sliding connection groove, one end of the first supporting spring is fixedly connected to the inner wall of the first sliding connection groove, and the other end of the first supporting spring is fixedly connected to a surface close to the first sliding connection seat.

[0018] As a further description of the above technical solution:

[0019] The power conversion device includes a bridge-type connecting frame, one end of the bridge-type connecting frame is fixedly connected to the surface of the driven stirring main shaft, the other end of the bridge-type connecting frame is sleeved with a telescopic sleeve, the bottom end of the telescopic sleeve is fixedly connected to a spherical hoop, a rolling ball is rollingly connected in the spherical hoop, and the rolling ball is rollingly connected to the inclined surface of the wedge seat.

[0020] As a further description of the above technical solution:

[0021] The wedge-shaped seat is set as two inclined surfaces along the rolling direction of the rolling ball, and a second sliding connection groove is opened on the inner wall of the telescopic sleeve at a position corresponding to the bridge-type connecting frame. A second sliding connection seat is slidingly connected in the second sliding connection groove, and the end face of the second sliding connection seat is fixedly connected to the end face inside the second sliding connection groove through a second supporting spring.

[0022] As a further description of the above technical solution:

[0023] The flow control component includes a diversion valve tube, which is clamped on the outer arc surface of the cutting wheel ring at a position corresponding to the stirring blade. A bucket-shaped cover is fixedly connected to the port of the diversion valve tube away from the cutting wheel ring. A hemisphere is embedded on the inner side of the bucket-shaped cover, and a flow hole is opened on the spherical surface of the hemisphere at a position corresponding to the bucket-shaped cover.

[0024] As a further description of the above technical solution:

[0025] A linkage seat is fixedly connected to the side of the hemispherical body facing away from the bucket-shaped cover, and a third sliding connection groove is provided on the inner wall of the diversion valve tube at a position corresponding to the linkage seat. A third sliding connection seat is slidingly connected in the third sliding connection groove, and the end face of the third sliding connection seat is fixedly connected to the end face inside the third sliding connection groove through a third supporting spring.

[0026] As a further description of the above technical solution:

[0027] A raw material introduction pipeline is clamped on the surface of the pharmaceutical tank body, and the port of the raw material introduction pipeline is located below the sealed piston disk. A first control valve is provided on the raw material introduction pipeline. A drug outlet pipeline is clamped on the bottom of the pharmaceutical tank body, and a second control valve is provided on the drug outlet pipeline.

[0028] A method for using production equipment, characterized in that the above-mentioned integrated production equipment for the pharmaceutical industry is used.

[0029] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are:

[0030] 1. In the present invention, through the designed convection component, the driven stirring main shaft will also drive the relative movement between the power conversion device and the wedge-shaped seat during the rapid rotation. Initially, the rolling ball at the bottom of the bridge-type connecting frame is located on the upper surface of the sealed piston disc. When the rolling ball rolls upward along an inclined surface of the wedge-shaped seat from the upper surface of the sealed piston disc, the sealed piston disc is subjected to the downward pressure of the power conversion device. The sealed piston disc will slide downward in the first sliding connection groove through the first sliding connection seat and exert pressure on the second supporting spring. As the sealed piston disc moves downward, the space above the sealed piston disc 402 inside the pharmaceutical tank body 2 gradually becomes larger, and the air pressure intensity inside it will gradually decrease and tend to a negative pressure state. According to the negative pressure drainage effect, the hemisphere will move away from the bucket-shaped cover, thereby increasing the flow rate of the drainage valve pipe per unit time. When the rolling ball rolls downward along another inclined surface of the wedge-shaped seat, the pressure of the rolling ball on the wedge-shaped seat gradually decreases, and the first supporting spring is reset. Under the action of elastic force, the first sliding connection seat will be pushed to drive the sealed piston disc to slide upward rapidly in the first sliding connection groove. Under the effect of the sealed piston disc, the air pressure intensity at the position above the sealed piston disc inside the pharmaceutical tank body will increase rapidly. Driven by the high air pressure, the mixture flowing into the driven stirring spindle through the flow control component will quickly flow back and spray out. The mixture stream flowing in or out through the diversion valve tube will act vertically on the eddy current generated by the stirring blades and the cutting wheel ring, thereby further increasing the flow trajectory of the mixture in the pharmaceutical tank body, assisting stirring, accelerating the stirring speed, and further improving the stirring effect. It can enhance the influence on the mixture near the inner wall of the pharmaceutical tank to a higher extent. On the one hand, it is beneficial to improve the uniformity of the reaction of the mixture. On the other hand, it can avoid the mixture near the inner wall of the pharmaceutical tank body from flowing slowly or standing still, which affects the heat transfer or heat dissipation effect. At the same time, it can also avoid scaling, ensuring that the heating device always has a good heat transfer effect.

[0031] 2. In the present invention, the operation of the electric motor is controlled by the designed stirring and mixing assembly. When the electric motor is working, its output shaft will drive the driven stirring spindle to rotate rapidly in the pharmaceutical tank body. Driven by the driven stirring spindle, multiple adapter sleeves together with the stirring blades will rotate rapidly in the pharmaceutical tank body. At the same time, driven by the stirring blades, the cutting wheel ring will shear the fluid generated by the centrifugal action of the driven stirring spindle, the adapter sleeve and the stirring blades. With the auxiliary effect of the cutting wheel ring, a strong vortex will be formed in the pharmaceutical tank body, further improving the stirring effect.

[0032] 3. In the present invention, the designed gas-liquid separation membrane and ventilation pipe are used to connect the driven stirring shaft and the pharmaceutical tank body, so as to facilitate the circulation and conversion between the airflow above the space above the sealed piston disk 402 and the airflow in the ventilation pipe 408 and the driven stirring shaft 301, and the gas-liquid separation membrane is used to achieve the separation between the gas and the colloidal fluid, so as to prevent the mixed material in the pharmaceutical tank body from entering the sealed piston disk. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 This is a schematic diagram of the overall structure of an integrated production device for the pharmaceutical industry and a method of use proposed by the present invention;

[0034] Figure 2 This is a schematic structural diagram of a cross-section of a pharmaceutical tank body in an integrated production device for the pharmaceutical industry and a method of use proposed by the present invention;

[0035] Figure 3 The present invention provides an integrated production equipment for pharmaceutical industry and a method of using the same Figure 2 The enlarged structural diagram at A in the middle;

[0036] Figure 4 This is a schematic structural diagram of a cross-section of a driven stirring main shaft in an integrated production device for the pharmaceutical industry and a method of use proposed by the present invention;

[0037] Figure 5 This is a cross-sectional structural schematic diagram of a power conversion device in an integrated production device for pharmaceutical industry and a method of use proposed by the present invention;

[0038] Figure 6 The present invention provides an integrated production equipment for pharmaceutical industry and a method of using the same Figure 5 The enlarged structural diagram at B in the middle;

[0039] Figure 7 This is a schematic cross-sectional view of a flow control component in an integrated production device for pharmaceutical industry and a method of use proposed by the present invention;

[0040] Figure 8 This is a schematic diagram of the structure of a pharmaceutical tank body in an integrated production device for the pharmaceutical industry and a method of use proposed by the present invention;

[0041] Fig. 9 A schematic diagram of a convection component in an integrated production device for the pharmaceutical industry and a method of use proposed by the present invention;

[0042] Fig.10 The present invention provides a schematic structural diagram of a stirring and mixing component in an integrated production device for the pharmaceutical industry and a method of using the device.

[0043] Legend:

[0044] 1. Shock-absorbing frame; 2. Pharmaceutical tank body; 3. Stirring and mixing assembly; 301. Driven stirring spindle; 302. Electric motor; 303. Adapter sleeve; 304. Stirring blade; 305. Cutting wheel ring; 4. Convection assembly; 401. Sliding connection sleeve; 402. Sealed piston disc; 403. First sliding connection seat; 404. First sliding connection groove; 405. First support spring; 406. Wedge seat; 407. Power conversion device; 4071. Bridge-type connecting frame; 4072. Telescopic sleeve; 4073. Second sliding connection Connecting seat; 4074, second sliding connecting groove; 4075, second supporting spring; 4076, spherical hoop; 4077, rolling ball; 408, ventilation pipe; 409, gas-liquid separation membrane; 5, flow control component; 501, drainage valve tube; 502, bucket-shaped cover; 503, hemispherical body; 504, flow hole; 505, linkage seat; 506, third sliding connecting seat; 507, third sliding connecting groove; 508, third supporting spring; 6, raw material introduction pipe; 7, first control valve; 8, drug outlet pipe; 9, second control valve. DETAILED DESCRIPTION

[0045] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0046] See also Figure 1-2 The present invention provides a technical solution: an integrated production equipment for pharmaceutical industry and a method of use, comprising a shock absorbing frame 1 and a pharmaceutical tank body 2 fixedly mounted on the shock absorbing frame 1, a stirring and mixing component 3 being mounted on the pharmaceutical tank body 2, and a convection component 4 being fixedly connected to a position of the pharmaceutical tank body 2 corresponding to the stirring and mixing component 3, and a flow control component 5 being further arranged on a surface of the stirring and mixing component 3 corresponding to the convection component 4;

[0047] The convection component 4 includes a sliding connection sleeve 401, which is slidably sleeved on the surface of the driven stirring main shaft 301, and a sealed piston disk 402 is fixedly sleeved on the outer arc surface of the sliding connection sleeve 401. The top of the sealed piston disk 402 is fixedly connected to a plurality of wedge seats 406 in an annular array, and a power conversion device 407 is fixedly connected above the wedge seat 406. The end of the power conversion device 407 away from the wedge seat 406 is fixedly connected to the surface of the driven stirring main shaft 301.

[0048] Specifically, Figure 2As shown, the stirring and mixing component 3 includes a driven stirring spindle 301, which is rotatably connected to the top of the inner side of the pharmaceutical tank body 2, and a plurality of through-connecting holes are opened on the surface of the driven stirring spindle 301 at positions corresponding to the inside of the pharmaceutical tank body 2, and a switching sleeve 303 is fixedly sleeved at positions corresponding to the through-connecting holes on the surface of the driven stirring spindle 301, and a plurality of stirring blades 304 are clamped on the outer arc surface of the switching sleeve 303, and a cutting wheel ring 305 is connected to the end of the stirring blade 304 away from the switching sleeve 303.

[0049] The specific implementation method is: control the operation of the electric motor 302. When the electric motor 302 is working, its output shaft will drive the driven stirring shaft 301 to rotate rapidly in the pharmaceutical tank body 2. Driven by the driven stirring shaft 301, multiple adapter sleeves 303 together with the stirring blades 304 will rotate rapidly in the pharmaceutical tank body 2. At the same time, driven by the stirring blades 304, the cutting wheel ring 305 will shear the fluid generated by the centrifugal action of the driven stirring shaft 301, the adapter sleeves 303 and the stirring blades 304. With the auxiliary effect of the cutting wheel ring 305, a strong vortex will be formed in the pharmaceutical tank body 2.

[0050] Specifically, Figure 2 and 4 As shown, the top of the driven stirring main shaft 301 is fixedly connected to the output shaft of the electric motor 302, the surface of the electric motor 302 body is fixedly connected to the top of the pharmaceutical tank body 2 through a frame, and the positions of the multiple through-connection holes are set according to the internal structure of the pharmaceutical tank body 2. The surface of the driven stirring main shaft 301 is also clamped with a ventilation duct 408, and the ventilation duct 408 is embedded with a gas-liquid separation membrane 409 in the port away from one end of the driven stirring main shaft 301.

[0051] The specific implementation method is as follows: the ventilation pipe 408 is used to connect the driven stirring shaft 301 and the pharmaceutical tank body 2, so as to facilitate the circulation and conversion between the airflow above the space above the sealed piston disk 402 and the airflow in the ventilation pipe 408 and the driven stirring shaft 301, and the gas-liquid separation membrane 409 is used to achieve the separation between the gas and the colloidal fluid, so as to prevent the mixed material at the bottom of the pharmaceutical tank body 2 from entering the space above the sealed piston disk 402 through multiple connecting holes, the ventilation pipe 408 and the driven stirring shaft 301.

[0052] Specifically, Figure 2-6As shown, a first sliding connection groove 404 is opened on the inner wall of the medicine tank body 2 at a position corresponding to the sealed piston disk 402, and a first sliding connection seat 403 is slidingly connected in the first sliding connection groove 404. The first sliding connection seat 403 and the opposite surface of the sealed piston disk 402 are fixedly connected, and a first supporting spring 405 is embeddedly connected at a position corresponding to the first sliding connection seat 403 on the inner side of the first sliding connection groove 404, one end of the first supporting spring 405 is fixedly connected to the inner wall of the first sliding connection groove 404, and the other end of the first supporting spring 405 is fixedly connected to a surface close to the first sliding connection seat 403.

[0053] Specifically, the power conversion device 407 includes a bridge-type connecting frame 4071, one end of the bridge-type connecting frame 4071 is fixedly connected to the surface of the driven stirring main shaft 301, and the other end of the bridge-type connecting frame 4071 is sleeved with a telescopic sleeve 4072, and the bottom end of the telescopic sleeve 4072 is fixedly connected with a spherical hoop 4076, and a rolling ball 4077 is rollingly connected in the spherical hoop 4076, and the rolling ball 4077 is rollingly connected on the inclined surface of the wedge-shaped seat 406, and the wedge-shaped seat 406 is set as two inclined surfaces along the rolling direction of the rolling ball 4077, and a second sliding connection groove 4074 is opened on the inner wall of the telescopic sleeve 4072 at a position corresponding to the bridge-type connecting frame 4071, and a second sliding connection seat 4073 is slidingly connected in the second sliding connection groove 4074, and the end face of the second sliding connection seat 4073 is fixedly connected to the end face inside the second sliding connection groove 4074 through a second support spring 4075.

[0054] The specific implementation method is as follows: during the rapid rotation of the driven stirring main shaft 301, it will also drive the relative movement between the power conversion device 407 and the wedge-shaped seat 406. Initially, the rolling ball 4077 at the bottom of the bridge-type connecting frame 4071 is located on the upper surface of the sealed piston disc 402. When the rolling ball 4077 rolls upward along an inclined surface of the wedge-shaped seat 406 from the upper surface of the sealed piston disc 402, the sealed piston disc 402 is subjected to the downward pressure of the power conversion device 407. The sealed piston disc 402 will slide downward in the first sliding connecting groove 404 through the first sliding connecting seat 403 and apply pressure to the second supporting spring 4075. As the sealed piston disc 402 moves downward, the space above the sealed piston disc 402 inside the pharmaceutical tank body 2 gradually becomes larger, and the air pressure intensity inside it will gradually decrease. When the rolling ball 4077 In the process of rolling downward along the other inclined surface of the wedge-shaped seat 406, due to the gradual reduction of the pressure exerted by the rolling ball 4077 on the wedge-shaped seat 406, the first sliding connection seat 403 will be pushed to drive the sealed piston disc 402 to slide upward rapidly in the first sliding connection groove 404 under the action of the reset elastic force of the first support spring 405. Under the effect of the sealed piston disc 402, the air pressure intensity at the position above the sealed piston disc 402 inside the pharmaceutical tank body 2 will increase rapidly. Driven by the high air pressure, the mixture flowing into the driven stirring spindle 301 through the flow control component 5 will quickly flow back and be ejected. The mixture stream flowing in or out through the diversion valve tube 501 will act vertically on the vortex generated by the stirring blades 304 and the cutting wheel ring 305, thereby further increasing the flow trajectory of the mixture in the pharmaceutical tank body 2.

[0055] Specifically, Figure 7 As shown, the flow control component 5 includes a drainage valve tube 501, which is clamped on the outer arc surface of the cutting wheel ring 305 at a position corresponding to the stirring blade 304, and a bucket-shaped cover 502 is fixedly connected to the port of the drainage valve tube 501 away from the cutting wheel ring 305. A hemispherical body 503 is embedded in the inner side of the bucket-shaped cover 502, and a flow hole 504 is opened on the spherical surface of the hemispherical body 503 at a position corresponding to the bucket-shaped cover 502, and a linkage seat 505 is fixedly connected on the side of the hemispherical body 503 away from the bucket-shaped cover 502. A third sliding connection groove 507 is opened on the inner wall of the drainage valve tube 501 at a position corresponding to the linkage seat 505, and a third sliding connection seat 506 is slidably connected in the third sliding connection groove 507. The end face of the third sliding connection seat 506 is fixedly connected to the end face inside the third sliding connection groove 507 through a third supporting spring 508.

[0056] The specific implementation method is as follows: the air pressure intensity above the sealed piston disk 402 inside the pharmaceutical tank body 2 will gradually decrease and tend to a negative pressure state. According to the negative pressure drainage effect, the hemispherical body 503 will move away from the bucket-shaped cover 502, thereby increasing the flow rate of the drainage valve tube 501 per unit time.

[0057] Specifically, Figure 1 As shown, a raw material introduction pipe 6 is clamped on the surface of the pharmaceutical tank body 2, and a port of the raw material introduction pipe 6 is located below the sealed piston disk 402. A first control valve 7 is provided on the raw material introduction pipe 6. A drug outlet pipe 8 is clamped on the bottom of the pharmaceutical tank body 2, and a second control valve 9 is provided on the drug outlet pipe 8.

[0058] The specific implementation method is as follows: by opening the first control valve 7, the drug production ingredients can be introduced into the interior of the pharmaceutical tank body 2 through the raw material introduction pipe 6, and by opening the second control valve 9, the produced drugs can be discharged through the drug product outlet pipe.

[0059] Working principle: When in use, the electric motor 302 is controlled to run. When the electric motor 302 is working, its output shaft will drive the driven stirring shaft 301 to rotate rapidly in the pharmaceutical tank body 2. Driven by the driven stirring shaft 301, multiple adapter sleeves 303 together with the stirring blades 304 will rotate rapidly in the pharmaceutical tank body 2. At the same time, driven by the stirring blades 304, the cutting wheel ring 305 will shear the fluid generated by the centrifugal action of the driven stirring shaft 301, the adapter sleeve 303 and the stirring blades 304. With the auxiliary effect of the cutting wheel ring 305, a strong vortex will be formed in the pharmaceutical tank body 2, further improving the stirring effect. During the rapid rotation of the driven stirring shaft 301, It will drive the power conversion device 407 and the wedge-shaped seat 406 to move relative to each other. Initially, the rolling ball 4077 at the bottom of the bridge-type connecting frame 4071 is located on the upper surface of the sealed piston disc 402. When the rolling ball 4077 rolls upward along an inclined surface of the wedge-shaped seat 406 from the upper surface of the sealed piston disc 402, the sealed piston disc 402 is subjected to the downward pressure of the power conversion device 407. The sealed piston disc 402 will slide downward in the first sliding connecting groove 404 through the first sliding connecting seat 403 and apply pressure to the second supporting spring 4075. As the sealed piston disc 402 moves downward, the space above the sealed piston disc 402 inside the pharmaceutical tank body 2 gradually increases, and the air pressure strength inside it will increase. The pressure inside the medicine tank 2 will increase rapidly as the pressure on the medicine tank 2 increases. Under the action, the mixture flowing into the driven stirring main shaft 301 through the flow control component 5 will quickly flow back and spray out, and the mixture stream flowing in or out through the diversion valve tube 501 will vertically act on the vortex generated by the stirring blade 304 and the cutting wheel ring 305, thereby further increasing the flow trajectory of the mixture in the pharmaceutical tank body 2, assisting stirring, accelerating the stirring speed, and further improving the stirring effect. It can enhance the ability to influence the mixture near the inner wall of the pharmaceutical tank body 2 to a higher extent. On the one hand, it is beneficial to improve the uniformity of the reaction of the mixture. On the other hand, it can avoid the mixture near the inner wall of the pharmaceutical tank body 2 from flowing slowly or standing still, which affects the heat transfer or heat dissipation effect, and also avoids scaling.Ensure that the heating device always has a good heat transfer effect.

[0060] The above are only preferred specific implementation modes of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical solutions and inventive concepts of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. An integrated production equipment for pharmaceutical industry, comprising a shock absorbing frame (1) and a pharmaceutical tank body (2) fixedly mounted on the shock absorbing frame (1), a stirring and mixing assembly (3) mounted on the pharmaceutical tank body (2), and a convection assembly (4) fixedly connected to the position of the stirring and mixing assembly (3) inside the pharmaceutical tank body (2), and a flow control assembly (5) is also arranged on the surface of the stirring and mixing assembly (3) at a position corresponding to the convection assembly (4), characterized in that: The convection component (4) comprises a sliding connection sleeve (401), the stirring and mixing component (3) comprises a driven stirring main shaft (301), and the sliding connection sleeve (401) is slidably sleeved on the surface of the driven stirring main shaft (301), a sealed piston disc (402) is fixedly sleeved on the outer arc surface of the sliding connection sleeve (401), a plurality of wedge-shaped seats (406) are fixedly connected to the top of the sealed piston disc (402) in an annular array, a power conversion device (407) is fixedly connected above the wedge-shaped seat (406), and one end of the power conversion device (407) away from the wedge-shaped seat (406) is fixedly connected to the surface of the driven stirring main shaft (301).

2. The integrated production equipment for pharmaceutical industry according to claim 1, characterized in that: The driven stirring main shaft (301) is rotatably connected to the top of the inner side of the pharmaceutical tank body (2); a plurality of through-connection holes are provided on the surface of the driven stirring main shaft (301) at positions corresponding to the inside of the pharmaceutical tank body (2); and a conversion sleeve (303) is fixedly sleeved on the surface of the driven stirring main shaft (301) at positions corresponding to the through-connection holes; a plurality of stirring blades (304) are clamped on the outer arc surface of the conversion sleeve (303); and a cutting wheel ring (305) is connected to one end of the stirring blade (304) away from the conversion sleeve (303).

3. The integrated production equipment for pharmaceutical industry according to claim 2, characterized in that: The top end of the driven stirring main shaft (301) is fixedly connected to the output shaft of the electric motor (302), the surface of the electric motor (302) is fixedly connected to the top of the pharmaceutical tank body (2) through a frame, and the positions of the multiple through-connection holes are set according to the internal structure of the pharmaceutical tank body (2).

4. The integrated production equipment for pharmaceutical industry according to claim 1, characterized in that: A ventilation pipe (408) is also clamped on the surface of the driven stirring main shaft (301), and a gas-liquid separation membrane (409) is embedded and connected in a port of the ventilation pipe (408) at one end away from the driven stirring main shaft (301).

5. The integrated production equipment for pharmaceutical industry according to claim 4, characterized in that: A first sliding connection groove (404) is provided on the inner wall of the pharmaceutical tank body (2) at a position corresponding to the sealed piston disk (402); a first sliding connection seat (403) is slidably connected in the first sliding connection groove (404); the first sliding connection seat (403) and the opposite surface of the sealed piston disk (402) are fixedly connected; and a first supporting spring (405) is embeddedly connected at a position corresponding to the first sliding connection seat (403) on the inner side of the first sliding connection groove (404); one end of the first supporting spring (405) is fixedly connected to the inner wall of the first sliding connection groove (404); and the other end of the first supporting spring (405) is fixedly connected to a surface close to the first sliding connection seat (403).

6. The integrated production equipment for pharmaceutical industry according to claim 1, characterized in that: The power conversion device (407) comprises a bridge-type connecting frame (4071), one end of the bridge-type connecting frame (4071) is fixedly connected to the surface of the driven stirring main shaft (301), the other end of the bridge-type connecting frame (4071) is sleeved with a telescopic sleeve (4072), the bottom end of the telescopic sleeve (4072) is fixedly connected with a spherical hoop (4076), a rolling ball (4077) is rollingly connected inside the spherical hoop (4076), and the rolling ball (4077) is rollingly connected to the inclined surface of the wedge-shaped seat (406).

7. The integrated production equipment for pharmaceutical industry according to claim 6, characterized in that: The wedge-shaped seat (406) is set as two inclined surfaces along the rolling direction of the rolling ball (4077), and a second sliding connection groove (4074) is opened at a position corresponding to the bridge-type connecting frame (4071) on the inner wall of the telescopic sleeve (4072), and a second sliding connection seat (4073) is slidingly connected in the second sliding connection groove (4074), and the end face of the second sliding connection seat (4073) is fixedly connected to the end face inside the second sliding connection groove (4074) through a second supporting spring (4075).

8. The integrated production equipment for pharmaceutical industry according to claim 1, characterized in that: The flow control component (5) comprises a diversion valve tube (501), the diversion valve tube (501) being clamped on a position on the outer arc surface of the cutting wheel ring (305) corresponding to the stirring blade (304), a bucket-shaped cover (502) being fixedly connected to the port at one end of the diversion valve tube (501) away from the cutting wheel ring (305), a hemisphere (503) being embedded in the inner side of the hemisphere (502), and a flow hole (504) being provided on the spherical surface of the hemisphere (503) at a position corresponding to the bucket-shaped cover (502); A linkage seat (505) is fixedly connected to the side of the hemispherical body (503) facing away from the bucket-shaped cover (502); a third sliding connection groove (507) is provided on the inner wall of the diversion valve tube (501) at a position corresponding to the linkage seat (505); a third sliding connection seat (506) is slidingly connected in the third sliding connection groove (507); and an end surface of the third sliding connection seat (506) is fixedly connected to the end surface inside the third sliding connection groove (507) via a third supporting spring (508).

9. The integrated production equipment for pharmaceutical industry according to claim 1, characterized in that: A raw material introduction pipe (6) is clamped on the surface of the pharmaceutical tank body (2), and the port of the raw material introduction pipe (6) is located below the sealed piston disk (402). A first control valve (7) is provided on the raw material introduction pipe (6). A drug outlet pipe (8) is clamped on the bottom of the pharmaceutical tank body (2), and a second control valve (9) is provided on the drug outlet pipe (8).

10. A method for using a production device, characterized in that: An integrated production device for the pharmaceutical industry as described in any one of claims 1 to 8 is used.

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