Commercial variable-gravity simulation three-dimensional rotary spherical bioreactor and chemical reaction kettle

Through a spherical design of bioreactors and chemical reactors, combined with three-dimensional slewing motion, the problems of cell damage and liquid turbulence in the prior art are solved, and the uniform growth and adequacy of the reaction of cells are achieved, which is suitable for the different needs of biopharmaceuticals and chemical pharmaceuticals.

CN119875774APending Publication Date: 2025-04-25SUZHOU SAIJI BIOTECHNOLOGY CO LTD
View PDF 0 Cites 0 Cited by

Patent Information

Application Number
CN202411744347.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-11-30
Publication Date
2025-04-25

AI Technical Summary

Technical Problem

The cylinder structures of existing bioreactors and chemical reactors are prone to damage cells when rotated, and the corners of the internal geometric structure lead to increased liquid turbulence and shear force, destroying the growth environment, and unable to meet the needs of biopharmaceuticals and chemical pharmaceuticals for uniform and gravity environment.

Method used

The spherical design of bioreactors and chemical reactors simulate different gravity environments through three-dimensional slewing motion, avoiding liquid turbulence and shear enhancement caused by internal corners, ensuring uniform growth of cells and sufficient mixing of reactants.

Benefits of technology

The adequacy of uniform growth and reaction of cells in biopharmaceuticals and chemical pharmaceuticals has been achieved, which reduces cell damage and production costs, improves production efficiency, and simulates microgravity and supergravity environments, which are suitable for different pharmaceutical needs.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN119875774A_ABST
    Figure CN119875774A_ABST
Patent Text Reader

Abstract

The invention discloses a commercial variable-gravity simulation three-dimensional rotary spherical bioreactor and chemical reaction kettle which comprises a fixed frame body, a first power motor, a second power motor, an outer rotating ring, an inner rotating ring and a spherical bioreactor and chemical reaction kettle body, the first power motor and the second power motor are in transmission connection with a first transmission assembly and a second transmission assembly respectively, the first transmission assembly is in transmission connection with the outer rotating ring, the second transmission assembly is in transmission connection with the inner rotating ring, and the inner rotating ring is arranged in an inner ring of the outer rotating ring through a connecting piece. The spherical bioreactor and the chemical reaction kettle body are driven by the outer rotating ring and the inner rotating ring to do rotary motion in a three-dimensional space and can rotate along the X axis and the Y axis, and the spherical bioreactor and the chemical reaction kettle body can be driven by the outer rotating ring and the inner rotating ring to do rotary motion in the three-dimensional space. Various simulated gravity environments such as a microgravity effect, a semi-gravity effect and a supergravity effect can be simulated through the rotation track.
Need to check novelty before this filing date? Find Prior Art

Description

Technical Field

[0001] The present invention relates to the field of biopharmaceuticals, chemical pharmaceutics and microbiological devices, and in particular to a commercial variable gravity simulated three-dimensional rotating spherical bioreactor, a chemical reactor and a three-dimensional constant speed or random rotating chemical reactor. Background Art

[0002] Bioreactors and chemical reactors refer to reaction systems that use naturally existing microorganisms or microorganisms with special degradation capabilities to inoculate into liquid or solid phases. They are equipment or systems that use biological systems (such as microorganisms, plant cells, animal cells or enzymes, etc.) as catalysts to carry out biochemical reactions in vitro.

[0003] Existing bioreactors, chemical reactors, and chemical reactors are generally cylindrical structures, with one or more mechanical blades driven by a motor in the vertical direction to stir the liquid or emulsion. This mode of movement can only rotate in one direction, that is, an axial direction, and cannot meet current requirements, especially in the field of biopharmaceuticals. The mechanical blades of this structure can easily break some healthy cells while rotating, resulting in an increase in the number of sub-healthy or dead cells, increasing production costs and reducing production efficiency. In addition, whether it is a cylindrical or other shaped bioreactor, chemical reactor or chemical reactor, its internal space geometry inevitably has many corners. When the liquid in the container moves dynamically, these inevitable corners will cause strong impacts, thereby causing liquid turbulence and increased shear force, destroying the growth environment. Summary of the invention

[0004] The main purpose of the present invention is to provide a commercial variable gravity simulation three-dimensional rotating spherical bioreactor and chemical reactor. This container, which is currently the first of its kind in the world, adopts a unique geometric structure spherical design and cleverly avoids the corners of other geometric structures, thereby ensuring that even in three-dimensional dynamic rotation, the container itself will not cause severe turbulence or increase in shear force of the liquid in the container. At the same time, the probability of cells or other particles suspended in the liquid approaching the three-dimensional rotation center, that is, the center of the spherical container, or moving away from the center of the spherical container within a period of time is equal, which improves the uniformity of the final product. This is very meaningful for the field of biopharmaceuticals, such as large-scale cell culture, vaccine culture, and antibody preparation, as well as for the traditional field of chemical pharmaceuticals, such as the full mixing and full reaction of liquid medicines with different components. By precisely controlling the three-dimensional rotation speed of the spherical container through the control system, different gravity environments can be simulated, and the lowest one can simulate 10 -3 g microgravity level and 10g hypergravity level. These different gravity environments are also very important for biopharmaceuticals or traditional chemical pharmaceuticals.

[0005] Especially for biopharmaceuticals, many existing laboratory data and public literature have shown that the growth rate of cells, maintenance of stemness, expression of specific proteins, etc. in microgravity environments have changed to varying degrees. In addition, under this simulated different gravity environment, some chemical reactions have also shown positive changes in reaction rate and reaction sufficiency. Therefore, the spherical container with a unique geometric structure design of this device cooperates with the algorithm to control its three-dimensional rotation movement, thereby bringing the traditional cylindrical bioreactor or chemical reactor driven by the loading and unloading blades and rotating in a single direction into a simulated microgravity or hypergravity three-dimensional rotation era, which is a technological change for traditional biopharmaceuticals or chemical pharmaceuticals.

[0006] To achieve the above object, the technical solution adopted by the present invention is:

[0007] A commercial variable gravity simulation three-dimensional rotating spherical bioreactor and chemical reactor, comprising a fixed frame body, a first power motor, a second power motor, an outer rotating ring, an inner rotating ring, a fixed connecting piece and the spherical bioreactor and chemical reactor body, the fixed frame body is fixedly mounted with the first power motor and the second power motor, the first power motor and the second power motor are respectively connected to a first transmission assembly and a second transmission assembly, the fixed connecting piece is provided with a sliding connection groove, the outer rotating ring and the inner rotating ring are slidably connected in the sliding connection groove, the fixed connecting piece is fixedly connected to the fixed frame body, the first transmission assembly is connected to the outer rotating ring, the second transmission assembly is connected to the inner rotating ring, the inner rotating ring is arranged in the inner ring of the outer rotating ring through a connecting piece, and the inner ring of the inner rotating ring is fixedly connected to the spherical bioreactor and chemical reactor body.

[0008] Furthermore, the first transmission assembly and the second transmission assembly are fixedly mounted on the fixed frame body, and the first transmission assembly and the second transmission assembly have the same structure and both include a motor transmission wheel, a driven wheel, a transmission belt, a fixed seat, a rotating bearing and an output wheel. The motor transmission wheel is fixedly mounted on the output end of the first power motor or the second power motor, and a linear shaft hole is opened on the fixed seat, and a rotating bearing is fixedly mounted in the linear shaft hole, and a transmission shaft rod is fixedly connected to the inner ring of the rotating bearing, and a driven wheel is fixedly mounted on one end of the transmission shaft rod, and the driven wheel is connected to the motor transmission wheel through a transmission belt, and an output wheel is fixedly mounted on the other end of the transmission shaft rod, and the output wheel is tightly fitted and transmission-connected to the outer rotating ring or the inner rotating ring.

[0009] Furthermore, the fixed connecting member includes a first connecting member and a second connecting member, the first connecting member is provided with a sliding connecting groove, and the first connecting member is slidingly connected to the outer rotating ring or the inner rotating ring through the sliding connecting groove, and the second connecting member is provided with two sliding connecting grooves, and the second connecting member is slidingly connected to the outer rotating ring and the inner rotating ring respectively through the sliding connecting grooves.

[0010] Furthermore, the outer rotating ring and the inner rotating ring are set at a vertical angle.

[0011] Furthermore, the outer ring surfaces of the outer rotating ring and the inner rotating ring are provided with first meshing teeth, and the output wheel is provided with second meshing teeth meshing with the meshing teeth.

[0012] Furthermore, the spherical bioreactor and chemical reactor body comprises two upper and lower hemispherical structures, and a connecting part is provided on the connecting surface of the two hemispherical structures. The connecting parts of the two hemispherical structures are locked together by screws, and the connecting part is fixedly connected to the inner ring surface of the inner rotating ring.

[0013] Furthermore, the inner rotating ring includes a first ring portion and a second ring portion, the first ring portion is fixedly arranged on the inner ring of the second ring portion, and the first ring portion and the second ring portion have the same center, the width of the first ring portion is smaller than the width of the second ring portion, and the first ring portion is fixedly provided with a plurality of connecting seats fixedly connected to the spherical bioreactor and the chemical reactor body.

[0014] Furthermore, the spherical bioreactor and chemical reactor body are also provided with a monitoring component for real-time high-definition monitoring video or photography of the interior of the spherical bioreactor and chemical reactor body, a gas input port for inputting gas into the spherical bioreactor and chemical reactor body, a direct heating component for heating the liquid in the spherical bioreactor and chemical reactor body, a sensor component for monitoring environmental parameters in the spherical bioreactor and chemical reactor body, a gas exchanger component, a liquid overflow component in the bioreactor and chemical reactor, a gas overflow component in the bioreactor and chemical reactor, a feeding port and a discharging port.

[0015] Furthermore, the gas exchanger assembly includes a plurality of gas exchangers, and the plurality of gas exchangers are connected in series via connecting pipes.

[0016] Furthermore, there are two second connecting members, which are respectively arranged at the connection between the inner rotating ring and the outer rotating ring. The inner rotating ring and the outer rotating ring are also respectively provided with no less than two first connecting members, and the spacing between the first connecting members is the same, and the spacing between the second connecting member and the first connection adjacent to the second connecting member is also the same.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] The present invention can control the driving motor through the controller, and change the rotation trajectory of the inner and outer structural frames in real time through the program algorithm to simulate various simulated gravity environments such as microgravity effect, semi-gravity effect and hypergravity effect;

[0019] The present invention designs the bioreactor and chemical reactor into a spherical shape. Compared with the traditional cylindrical bioreactor and chemical reactor, the structure has no obvious geometric corners, which avoids the strong impact on the dynamic movement of the liquid in the bioreactor and chemical reactor, thereby avoiding the liquid turbulence and the increase of shear force, which will damage the growth environment of the culture object.

[0020] The spherical cavity can ensure that the probability of the cultured object suspended therein approaching or moving away from the center of the sphere during free movement over a period of time is almost equal, thereby ensuring the uniformity of the growth of the cultured object;

[0021] When spherical bioreactors and chemical reactors are combined with three-dimensional motion modes, better mixing effects can be achieved. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a three-dimensional schematic diagram of the spherical bioreactor and chemical reactor body of the present invention;

[0023] Figure 2 It is a three-dimensional schematic diagram of the present invention;

[0024] Figure 3 It is a three-dimensional schematic diagram of the spherical bioreactor, the chemical reactor body, the outer rotating ring and the inner rotating ring of the present invention;

[0025] Figure 4 It is a front view schematic diagram of the spherical bioreactor, the chemical reactor body and the inner rotating ring of the present invention;

[0026] Figure 5 It is a three-dimensional schematic diagram of the inner rotating ring of the present invention;

[0027] Figure 6 It is a schematic cross-sectional perspective view of the inner rotating ring of the present invention;

[0028] Figure 7 is a transverse cross-sectional view of the inner rotating ring of the present invention;

[0029] Figure 8 It is a cross-sectional schematic diagram of the inner rotating ring and the output wheel meshing with each other according to the present invention.

[0030] Reference numerals

[0031] 1. Fixed frame body; 2. First power motor; 3. Second power motor; 4. Outer rotating ring; 5. Inner rotating ring; 6. Motor drive wheel; 7. Driven wheel; 8. Drive belt; 10. Output wheel; 11. First connecting piece; 12. Second connecting piece; 13. Sliding connection groove; 14. First meshing tooth portion; 15. Second meshing tooth portion; 16. Connecting portion; 17. First ring portion; 18. Second ring portion; 19. Connecting seat; 20. Monitoring component; 21. Gas input port; 22. Direct heating component; 23. Sensor component; 24. Gas exchanger component; 25. Liquid overflow component in bioreactor and chemical reactor; 26. Gas overflow component in bioreactor and chemical reactor; 27. Feeding port; 28. Discharge port; 29. ​​Connecting pipe; 101. Spherical bioreactor and chemical reactor body; 30. Tooth groove. DETAILED DESCRIPTION

[0032] The preferred embodiments of the present invention are described in detail below in conjunction with the accompanying drawings so that the advantages and features of the present invention can be more easily understood by those skilled in the art, thereby making a clearer and more definite definition of the protection scope of the present invention.

[0033] Example 1

[0034] See also Figure 1 As shown, this embodiment discloses a spherical bioreactor and chemical reactor, wherein the spherical bioreactor and chemical reactor body 101 comprises two upper and lower hemispherical structures, a connecting portion 16 is provided on the connecting surface of the two hemispherical structures, the connecting portions 16 of the two hemispherical structures are locked together by screws, and the connecting portion 16 is fixedly connected to the inner ring surface of the inner rotating ring 5, and the spherical bioreactor and chemical reactor body 101 is also provided with a monitoring component 20 for real-time high-definition monitoring video or photography inside the spherical bioreactor and chemical reactor body 101, a gas input port 21 for inputting gas into the spherical bioreactor and chemical reactor body 101, a direct heating component 22 for heating liquid in the spherical bioreactor and chemical reactor body 101, a sensor component 23 for monitoring environmental parameters in the spherical bioreactor and chemical reactor body 101, a gas exchanger component 24, a liquid overflow component 25 in the bioreactor and chemical reactor, a gas overflow component 26 in the bioreactor and chemical reactor, a feeding port 27 and a discharge port 28.

[0035] The inner cavity of the spherical bioreactor and chemical reactor is a hollow spherical structure. Compared with the traditional cylindrical bioreactor and chemical reactor, there is no obvious geometric corner in the structure, which avoids the strong impact on the dynamic movement of the liquid in the bioreactor and chemical reactor, thereby causing liquid turbulence and enhanced shear force to destroy the growth environment of the culture object;

[0036] The spherical cavity can ensure that the probability of the cultured object suspended therein approaching or moving away from the center of the sphere during free movement over a period of time is almost equal, thereby ensuring the uniformity of the growth of the cultured object;

[0037] Compared with reaction vessels of other geometric shapes, spherical reaction vessels can store more culture fluid in a certain space, which means that the culture capacity is greater and the economic benefits are higher;

[0038] The three-dimensional motion mode can achieve better mixing effect;

[0039] No mechanical stirring, no damage to cells or cultured objects, greatly reducing the proportion of dead cells inside the reaction vessel;

[0040] In a variable gravity environment, cells are less likely to settle.

[0041] Working principle:

[0042] The objects participating in the reaction, as well as raw materials, culture fluid, etc., enter the spherical bioreactor and chemical reactor body through the feed port 27. The environmental gas during the culture process enters the gas exchanger through the gas input port 21. Multiple gas exchangers are connected in series through connecting pipes 29 to increase the gas exchange surface area to ensure the gas demand in the bioreactor and chemical reactor.

[0043] The internal temperature of the spherical bioreactor and chemical reactor body is heated by a direct heating rod to ensure the appropriate temperature inside the reaction container. At the same time, the spherical bioreactor and chemical reactor are built with multiple environmental monitoring sensor components 23, such as temperature, pH value, dissolved oxygen, etc. At the same time, high-definition photography and video components are embedded on the surface of the spherical bioreactor and chemical reactor, through which real-time photography and monitoring of the spherical bioreactor and chemical reactor can be carried out.

[0044] During the production process, when the metabolites in the spherical bioreactor or chemical reactor cause the liquid in the spherical bioreactor or chemical reactor to expand or produce waste gas due to the reaction process, the liquid can overflow from the component or the gas can overflow from the component to ensure the safety of the spherical bioreactor or chemical reactor.

[0045] Example 2

[0046] See also Figure 2-8As shown, a commercial variable gravity simulated three-dimensional rotating spherical bioreactor and chemical reactor comprises a fixed frame body 1, a first power motor 2, a second power motor 3, an outer rotating ring 4, an inner rotating ring 5, a fixed connecting piece and a spherical bioreactor and chemical reactor body 101. The first power motor 2 and the second power motor 3 are fixedly mounted on the fixed frame body 1. The first power motor 2 and the second power motor 3 are respectively connected to the first transmission assembly and the second transmission assembly. A sliding connection groove 13 is provided on the fixed connecting piece. The outer rotating ring 4 and the inner rotating ring 5 are slidably connected in the sliding connection groove 13. The fixed connecting piece is fixedly connected to the fixed frame body 1. The first transmission assembly is connected to the outer rotating ring 4. The second transmission assembly is connected to the inner rotating ring 5. The inner rotating ring 5 is arranged in the inner ring of the outer rotating ring 4 through a connecting piece. The inner ring of the inner rotating ring 5 is fixedly connected to the spherical bioreactor and chemical reactor body 101.

[0047] The outer rotating ring 4 and the inner rotating ring 5 are set at a vertical angle.

[0048] The first transmission assembly and the second transmission assembly are fixedly mounted on the fixed frame body 1. The first transmission assembly has the same structure as the second transmission assembly, and both include a motor transmission wheel 6, a driven wheel 7, a transmission belt 8, a fixed seat, a rotating bearing and an output wheel 10. The motor transmission wheel 6 is fixedly mounted on the output end of the first power motor 2 or the second power motor 3. A linear shaft hole is provided on the fixed seat, and a rotating bearing is fixedly mounted in the linear shaft hole. The inner ring of the rotating bearing is fixedly connected to a transmission shaft, and one end of the transmission shaft is fixedly mounted with a driven wheel 7, and the driven wheel 7 is transmission-connected to the motor transmission wheel 6 through a transmission belt 8. The other end of the transmission shaft is fixedly mounted with an output wheel 10, and the output wheel 10 is tightly fitted and transmission-connected to the outer rotating ring 4 or the inner rotating ring 5.

[0049] The outer ring surfaces of the outer rotating ring 4 and the inner rotating ring 5 are provided with first meshing teeth 14 , and the output wheel 10 is provided with second meshing teeth 15 meshing with the meshing teeth.

[0050] It should be noted that a tooth groove 30 may be provided on the outer ring surfaces of the outer rotating ring 4 and the inner rotating ring 5 , and the first meshing tooth portion 14 is disposed in the tooth groove 30 .

[0051] The inner rotating ring 5 includes a first ring portion 17 and a second ring portion 18. The first ring portion 17 is fixedly arranged on the inner ring of the second ring portion 18, and the first ring portion 17 and the second ring portion 18 have the same center. The width of the first ring portion 17 is smaller than the width of the second ring portion 18. A plurality of connecting seats 19 fixedly connected to the spherical bioreactor and the chemical reactor body 101 are fixedly arranged on the first ring portion 17.

[0052] The fixed connecting member includes a first connecting member 11 and a second connecting member 12. The first connecting member 11 is provided with a sliding connecting groove 13, and the first connecting member 11 is slidingly connected to the outer rotating ring 4 or the inner rotating ring 5 through the sliding connecting groove 13. The second connecting member 12 is provided with two sliding connecting grooves 13, and the second connecting member 12 is slidingly connected to the outer rotating ring 4 and the inner rotating ring 5 respectively through the sliding connecting grooves 13.

[0053] There are two second connecting members 12, and the two second connecting members 12 are respectively arranged at the connection between the inner rotating ring 5 and the outer rotating ring 4. The inner rotating ring 5 and the outer rotating ring 4 are also respectively provided with no less than two first connecting members 11, and the spacing between the first connecting members 11 is the same, and the spacing between the second connecting member 12 and the first connection adjacent to the second connecting member 12 is also the same.

[0054] The first connecting member 11 is used for limiting the support of the outer rotating ring 4 or the inner rotating ring 5 alone, and the second connecting member 12 is also used for limiting the position of the outer rotating ring 4 and the inner rotating ring 5 .

[0055] It should be noted that a plurality of spherical bioreactors and chemical reactor bodies can be installed on one fixing frame body 1 .

[0056] The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiment. Any equivalent modifications or changes made by ordinary technicians in this field based on the contents disclosed by the present invention should be included in the protection scope recorded in the claims.

Claims

1. A commercial variable gravity simulated three-dimensional rotating spherical bioreactor and chemical reactor, characterized by: The invention comprises a fixed frame body (1), a first power motor (2), a second power motor (3), an outer rotating ring (4), an inner rotating ring (5), a fixed connecting piece and a spherical bioreactor and a chemical reactor body (101). The first power motor (2) and the second power motor (3) are fixedly mounted on the fixed frame body (1). The first power motor (2) and the second power motor (3) are respectively connected to a first transmission assembly and a second transmission assembly in a transmission manner. A sliding connection groove (13) is provided on the fixed connecting piece. The outer rotating ring (4) and the inner rotating ring (5) are slidably connected in the sliding connection groove (13). The fixed connecting piece is fixedly connected to the fixed frame body (1). The first transmission assembly is connected to the outer rotating ring (4) in a transmission manner. The second transmission assembly is connected to the inner rotating ring (5) in a transmission manner. The inner rotating ring (5) is arranged in the inner ring of the outer rotating ring (4) through a connecting piece. The inner ring of the inner rotating ring (5) is fixedly connected to the spherical bioreactor and the chemical reactor body (101).

2. A commercial variable gravity simulated three-dimensional rotating spherical bioreactor and chemical reactor according to claim 1, characterized in that: The first transmission assembly and the second transmission assembly are fixedly mounted on the fixing frame body (1). The first transmission assembly and the second transmission assembly have the same structure and both comprise a motor transmission wheel (6), a driven wheel (7), a transmission belt (8), a fixing seat, a rotary bearing and an output wheel (10). The motor transmission wheel (6) is fixedly mounted on the output end of the first power motor (2) or the second power motor (3). A linear shaft hole is provided on the fixing seat. A rotary bearing is fixedly mounted in the linear shaft hole. The inner ring of the rotary bearing is fixedly connected to a transmission shaft. A driven wheel (7) is fixedly mounted on one end of the transmission shaft. The driven wheel (7) is transmission-connected to the motor transmission wheel (6) via a transmission belt (8). The output wheel (10) is fixedly mounted on the other end of the transmission shaft. The output wheel (10) is transmission-connected to the outer rotating ring (4) or the inner rotating ring (5) in a tightly fitting manner.

3. A commercial variable gravity simulated three-dimensional rotating spherical bioreactor and chemical reactor according to claim 1, characterized in that: The fixed connection member comprises a first connection member (11) and a second connection member (12); the first connection member (11) is provided with a sliding connection groove (13); the first connection member (11) is slidably connected to the outer rotating ring (4) or the inner rotating ring (5) via the sliding connection groove (13); the second connection member (12) is provided with two sliding connection grooves (13); the second connection member (12) is slidably connected to the outer rotating ring (4) and the inner rotating ring (5) respectively via the sliding connection grooves (13).

4. A commercial variable gravity simulated three-dimensional rotating spherical bioreactor and chemical reactor according to claim 1, characterized in that: The outer rotating ring (4) and the inner rotating ring (5) are set at a vertical angle.

5. A commercial variable gravity simulated three-dimensional rotating spherical bioreactor and chemical reactor according to claim 2, characterized in that: The outer ring surfaces of the outer rotating ring (4) and the inner rotating ring (5) are provided with first meshing teeth (14), and the output wheel (10) is provided with second meshing teeth (15) meshing with the meshing teeth.

6. A commercial variable gravity simulated three-dimensional rotating spherical bioreactor and chemical reactor according to claim 1, characterized in that: The spherical bioreactor and chemical reactor body (101) comprises two upper and lower hemispherical structures, and a connecting portion (16) is provided on the connecting surfaces of the two hemispherical structures. The connecting portions (16) of the two hemispherical structures are locked together by screws, and the connecting portion (16) is fixedly connected to the inner ring surface of the inner rotating ring (5).

7. A commercial variable gravity simulated three-dimensional rotating spherical bioreactor and chemical reactor according to claim 1, characterized in that: The inner rotating ring (5) comprises a first ring portion (17) and a second ring portion (18), wherein the first ring portion (17) is fixedly arranged on the inner ring of the second ring portion (18), and the first ring portion (17) and the second ring portion (18) have the same center, the width of the first ring portion (17) is smaller than the width of the second ring portion (18), and a plurality of connection seats (19) fixedly connected to the spherical bioreactor and the chemical reactor body (101) are fixedly arranged on the first ring portion (17).

8. The commercial variable gravity simulated three-dimensional rotating spherical bioreactor and chemical reactor according to claim 1, characterized in that: The spherical bioreactor or chemical reactor body (101) is also provided with a monitoring component (20) for real-time high-definition monitoring video or photography of the interior of the spherical bioreactor or chemical reactor body (101), a gas input port (21) for inputting gas into the spherical bioreactor or chemical reactor body (101), a direct heating component (22) for heating liquid in the spherical bioreactor or chemical reactor body (101), a sensor component (23) for monitoring environmental parameters in the spherical bioreactor or chemical reactor body (101), a gas exchanger component (24), a liquid overflow component (25) in the bioreactor or chemical reactor, a gas overflow component (26) in the bioreactor or chemical reactor, a feeding port (27) and a discharging port (28).

9. A commercial variable gravity simulated three-dimensional rotating spherical bioreactor and chemical reactor according to claim 8, characterized in that: The gas exchanger assembly (24) comprises a plurality of gas exchangers, and the plurality of gas exchangers are connected in series via a connecting pipe (29).

10. A commercial variable gravity simulated three-dimensional rotating spherical bioreactor and chemical reactor according to claim 3, characterized in that: There are two second connecting members (12), and the two second connecting members (12) are respectively arranged at the connection between the inner rotating ring (5) and the outer rotating ring (4). The inner rotating ring (5) and the outer rotating ring (4) are also respectively provided with no less than two first connecting members (11), and the spacing between the first connecting members (11) is the same, and the spacing between the second connecting member (12) and the first connection adjacent to the second connecting member (12) is also the same.