Detection equipment and method for biopharmacy

Abstract

The invention provides biopharmacy detection equipment and method, and belongs to the technical field of biopharmacy, the biopharmacy detection equipment comprises a box body, a driving assembly is arranged on the top wall of the box body, a pump is fixedly connected to the top wall of the box body, a base is arranged on the inner wall of the box body, a fixed gear is fixedly connected to the outer wall of the base, and the biopharmacy detection equipment further comprises a cleaning assembly, the cleaning assembly comprises a rotating column connected with the output end of the driving assembly, and one end of the rotating column penetrates through the box body and is connected with symmetrically-distributed extension pipes. According to the device, through cooperation of a driving bevel gear A, a driven bevel gear A, a driving bevel gear B, a driven bevel gear B and a driven bevel gear C, fan blades can rotate to form air draft, a filter plate vibrates to prevent blockage, a scraper rotates to scrape and clean impurities on the inner wall of the box body, and internal drying or cleaning is conducted through revolution and rotation of a spray pipe; the functionality of the equipment is improved, the dependence on multiple pieces of equipment is reduced, and the space and the investment cost are saved.

Description

Technical Field

[0001] The present invention relates to the technical field of biopharmaceuticals, and in particular to a biopharmaceutical detection device and method. Background Art

[0002] Biopharmaceuticals are a type of drug developed and produced using biotechnology and biomaterials. They are based on the understanding and application of biological processes in organisms. With the rapid development of biotechnology such as genetic engineering, cell culture, and monoclonal antibody technology, biopharmaceuticals have begun to play an increasingly important role in the treatment of various complex diseases such as cancer, diabetes, and autoimmune diseases. Compared with traditional chemical synthetic drugs, biopharmaceuticals can provide more precise targeted treatments with higher specificity and biocompatibility. In recent years, with the continuous advancement of science and technology and the rapid expansion of the biopharmaceutical market, its development and application are gradually changing the face of modern medicine and opening up new directions for the prevention and treatment of diseases. Microorganisms play an important role in the detection, production monitoring, and safety and effectiveness evaluation of biopharmaceuticals. Through the management and detection of microorganisms, the quality of biopharmaceutical products can be ensured, thereby ensuring the safety of patients.

[0003] After searching, the Chinese patent application number CN214765605U discloses a safety detection and analysis workbench for biopharmaceuticals, including a body and a cleaning device. The body is a safety detection and analysis workbench for biopharmaceuticals, the inner wall of the body is provided with a waste liquid tank, the surface of the body is fixedly connected with a switch, the lower surface of the body is fixedly connected with a bracket, the cleaning device is arranged on the inner wall of the body, the cleaning device includes a sliding rod, the sliding rod is fixedly connected with the inner wall of the body, the surface of the sliding rod is sleeved with a sliding box, the inner wall of the sliding box is welded with a sliding support plate, and the inner bottom wall of the sliding box is fixedly connected with a motor;

[0004] Although the above patent provides a cleaning device, when cleaning the workbench, the motor is turned on, the motor drives the sliding box to slide on the surface of the sliding rod through the gear, the sliding box drives the connecting rod and the mounting plate to move, and the mounting plate drives the brush to clean the workbench during the movement. When the sliding box is against the inner wall of the workbench, the motor reverses to drive the sliding box, the connecting rod, and the mounting plate back to their original positions to achieve another cleaning. At present, most of the safety testing and analysis workbenches dedicated to biopharmaceuticals on the market will have a large amount of residual drugs in the workbench after use. When the workbench is subjected to a new test, inaccurate data may be obtained. The application of this device avoids the above problems and improves the ease of use of the equipment, but there are still the following deficiencies during use: 1. The cleaning and use of the device is not thorough, which affects the detection accuracy; 2. The waste liquid of the device is centrally collected and treated, and different waste liquids have different effective treatment methods, and its safety is not guaranteed.

[0005] Therefore, there is an urgent need for a biopharmaceutical detection device and method to solve the above problems. Summary of the invention

[0006] The object of the present invention is to provide a biopharmaceutical detection device and method to solve the problems raised in the above background technology.

[0007] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0008] A biopharmaceutical detection device comprises a box, a driving assembly is arranged on the top wall of the box, a pump is fixedly connected to the top wall of the box, a base is arranged on the inner wall of the box, a fixed gear is fixedly connected to the outer wall of the base, and further comprises:

[0009] A cleaning assembly, the cleaning assembly comprising a rotating column connected to the output end of the driving assembly, one end of the rotating column passing through the box body and connected to symmetrically distributed extension pipes, one end of the extension pipe away from the rotating column is rotatably connected to a rotating pipe, the outer wall of the rotating pipe is fixedly connected to a uniformly distributed nozzle, and the outer wall of the rotating pipe is provided with a driven gear meshing with a fixed gear;

[0010] The collecting cone is fixedly connected to the inner wall of the box;

[0011] A three-way ball valve, the input end of which is connected to the pump, and the output end of which is respectively connected to the rotating column and the multi-function box;

[0012] A scraping component is arranged on the outer wall of the rotating column;

[0013] The filter thermostatic component is arranged on the outer wall of the multifunctional box, and the filter thermostatic component and the scraping component are matched with the cleaning component;

[0014] The classification component is arranged on the inner wall of the box.

[0015] As a preferred technical solution of the present application, the scraping assembly includes a driving plate fixedly connected to the outer wall of the rotating column, the outer wall of the driving plate is fixedly connected with symmetrically distributed scrapers, and the outer wall of the scraper is against the inner wall of the box.

[0016] As a preferred technical solution of the present application, the driving assembly includes a driving motor fixedly connected to the top wall of the box body, and the output end of the driving motor cooperates with the cleaning assembly.

[0017] As a preferred technical solution of the present application, the filter constant temperature assembly includes a filter box fixedly connected to the outer wall of the multi-functional box, the inner wall of the filter box is fixedly connected with evenly distributed strong tension springs, the end of the strong tension spring away from the filter box is fixedly connected with a filter plate, the inner wall of the filter plate is rotatably connected with an extrusion plate, the inner wall of the extrusion plate is fixedly connected with a driven rod, the outer wall of the driven rod is fixedly connected with evenly distributed fan blades, and the driven rod cooperates with the output end of the drive assembly.

[0018] As a preferred technical solution of the present application, the classification component includes a classification plate rotatably connected to the inner wall of the box, the outer wall of the classification plate is fixedly connected with evenly distributed driving handles, the top wall of the classification plate is provided with evenly distributed classification grooves, and the outer wall of the classification plate is provided with evenly distributed through holes B.

[0019] As a preferred technical solution of the present application, the outer wall of the box body is fixedly connected to two groups of rotating seats, the outer walls of the two groups of rotating seats are fixedly connected to rotating plates, the end of the rotating plate away from the rotating seat is fixedly connected to the box door, and the outer wall of the box door is fixedly connected to a pulling handle.

[0020] As a preferred technical solution of the present application, a through hole A is opened on the outer wall of the box body, and the positions of the through hole A and the through hole B correspond to each other.

[0021] As a preferred technical solution of the present application, the inner wall of the box body and the inner wall of the base are both fixedly connected with a feeding pipe.

[0022] As a preferred technical solution of the present application, the outer wall of the box body is fixedly connected with symmetrically distributed support frames, and one end of the support frame away from the box body is fixedly connected with a support plate.

[0023] The present invention also discloses a method for detecting biopharmaceuticals, which specifically comprises the following steps:

[0024] S1. When the driven rod rotates, the fan blades are driven to rotate to form draft. The draft passes through the filter plate to filter the dust in the air. At the same time, the rotation of the driven rod drives the extrusion plate to rotate. The center point of the extrusion plate is not at the same position as the connection point of the driven rod. Therefore, when the extrusion plate rotates with the driven rod, it will squeeze and push the filter plate to move repeatedly in the filter box. The strong tension spring exerts a pulling force on the filter plate to achieve the vibration of the filter plate, thereby preventing the filter plate from being blocked and reducing the cleaning frequency, thereby filtering impurities in the air and allowing particles or pollutants to pass through the filter plate more effectively, thereby improving the efficiency of the entire filtering process;

[0025] S2. When the exhaust air is formed and filtered, the pump is connected to the sterilizing liquid, and its three-way ball valve rotates a certain angle to cooperate with the pump and the exhaust air to deliver the mixed and filtered air to the rotating column to prevent gas or liquid leakage. The mixed sterilizing gas will be ejected through the extension tube, the rotating tube and the nozzle. When the rotating column rotates, it will drive the extension tube and the rotating tube to rotate, and then drive the driven gear to rotate. When the driven gear rotates, it will mesh with the fixed gear, so as to rotate, that is, the rotating tube and the nozzle rotate, so as to realize the revolution and rotation of the nozzle, ensure that there is no dead angle in the internal area sterilization and disinfection, and facilitate to improve the accuracy of detection or cultivation;

[0026] S3, the excess sterilizing liquid will eventually flow into the classification slot of the classification disk, and the classification slot can classify the substances formed inside the equipment during the microbial cultivation process, which is convenient for subsequent classification treatment, and the collected waste liquid is discharged through the through hole B and through hole A through the rotating classification disk;

[0027] S4. After the inside of the box is cleaned, the culture solution and the drug to be detected are added through the feeding tube. The drug is the drug to be detected, and the culture solution is the culture solution used by microorganisms, so that the microorganisms can cooperate in a sterile environment. After the culture is completed, it is mixed with the drug for detection. Since the microorganisms are always sterilely cultured in the box, the influence of bacteria is fundamentally eliminated, and the accuracy of the detection is improved;

[0028] S5. After use, the liquid and impurities attached to the inner wall of the box body 1 can be rotated by the scraper following the rotating column, and the inner wall of the box body can be scraped off by the scraper. With the help of sterilizing liquid, the inner wall of the box body can be quickly cleaned, which is convenient for the next step of detection, and the drying function can be achieved by heated air. At this time, the three-way ball valve can be flexibly adjusted to achieve the function of disinfection or drying of the spray liquid of the nozzle, which is flexible and versatile.

[0029] Compared with the prior art, the present invention has the following beneficial effects:

[0030] In the scheme of this application:

[0031] 1. By setting the spraying mode of revolution and rotation of the nozzle, the inside of the box can be sprayed without dead angles. At the same time, the scraper can be rotated to realize the cleaning of the inside of the box before and after use, ensuring that the inside of the box is in a sterile environment. The dirt and residue inside the box can be effectively removed, the cleaning rate and effect can be improved, the workload of manual cleaning can be reduced, the operation time can be shortened, and the overall detection efficiency can be improved. The cost of subsequent problem handling and re-production caused by pollution can be reduced. At the same time, the sterile environment can better increase the living space of microorganisms and improve the accuracy of biopharmaceutical detection, solving the problem of incomplete cleaning and use in the existing technology, which affects the detection accuracy;

[0032] 2. The waste liquid cleaned by the cleaning component can be classified and collected by the provided classification plate, and discharged through the through hole A and the through hole B. It is only necessary to rotate the classification plate, so as to facilitate subsequent treatment, ensure the effectiveness of waste liquid treatment, improve safety, and solve the problem that the waste liquid is centrally collected and treated in the prior art, different waste liquids have different effective treatment methods, and their safety is not guaranteed;

[0033] 3. The fan blades and the extrusion plate in the multifunctional box rotate following the driven rod, and the fan blades can form exhaust and filter impurities through the filter plate to improve the quality of air. At the same time, the filter plate is squeezed by the extrusion plate to vibrate, thereby preventing the deposition and agglomeration of solid particles on the filter plate, thereby maintaining the stability and efficiency of the operation process. When the air flows, the mixed air with the medicine delivered by the pump can disinfect the bacteria in the air, thereby providing sufficient clean air inside the box. The multifunctional box heats the air through the heating wire to provide a suitable temperature for the survival of microorganisms, and the temperature in the box can be quickly increased through the revolution and rotation of the nozzle. When the nozzle is spraying and cleaning or drying after spraying, the three-way ball valve can be adjusted to realize the opening and closing of the connecting pipe A and the connecting pipe B, which is convenient for using the heating wire in the multifunctional box to achieve the drying function during heating, and is flexibly applicable to the process of microbial culture and pharmaceutical testing;

[0034] 4. Through the coordination among driving bevel gear A, driven bevel gear A, driving bevel gear B, driven bevel gear B and driven bevel gear C, the fan blades can rotate to form ventilation, the filter plate can vibrate to prevent clogging, the scraper can rotate to scrape and clean the impurities on the inner wall of the box, and the nozzle can revolve and rotate to dry or clean the inside, thereby improving the functionality of the equipment, reducing dependence on multiple devices, and saving space and investment costs. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 A schematic diagram of the overall structure of the biopharmaceutical detection equipment and method provided in this application;

[0036] Figure 2 A schematic diagram of the internal structure of the biopharmaceutical detection device and method provided in this application;

[0037] Figure 3 A schematic diagram of the structure of the triangular connecting plate portion of the biopharmaceutical detection device and method provided in this application;

[0038] Figure 4 A schematic diagram of the structure of the collection cone of the biopharmaceutical detection device and method provided in this application;

[0039] Figure 5 A cross-sectional view of the box of the biopharmaceutical detection device and method provided in this application;

[0040] Figure 6 A schematic diagram of the structure of the classification disk portion of the biopharmaceutical detection device and method provided in this application;

[0041] Figure 7 A cross-sectional view of the classification tube of the biopharmaceutical detection equipment and method provided in this application;

[0042] Figure 8 A cross-sectional view of a filter box for the biopharmaceutical detection device and method provided in this application;

[0043] Fig. 9 This is a schematic diagram of the structure of the driven rod portion of the biopharmaceutical detection device and method provided in this application.

[0044] Indicated in the figure:

[0045] 1. Box body; 2. Support frame; 3. Support plate; 4. Rotating seat; 5. Rotating plate; 6. Box door; 7. Pull handle; 8. Mounting plate; 9. Multifunctional box; 10. Rotating column; 11. Driving plate; 12. Scraper; 13. Extension pipe; 14. Rotating pipe; 15. Spray pipe; 16. Classification plate; 17. Driving handle; 18. Through hole A; 19. Triangular connecting plate; 20. Base; 21. Fixed gear; 22. Driven gear; 23. Positioning ring; 24. Culture dish; 25. Feeding pipe; 26. Spacer; 27. Collection cone ; 28. Classification pipe; 29. ​​Classification slot; 30. Through hole B; 31. Vertical pipe; 32. Driving motor; 33. Bevel gear box; 34. Pump; 35. Driving bevel gear A; 36. Linkage rod; 37. Driven bevel gear A; 38. Driving bevel gear B; 39. Driven bevel gear B; 40. Driven bevel gear C; 41. Driven rod; 42. Filter box; 43. Filter plate; 44. Extrusion plate; 45. Strong tension spring; 46. Three-way ball valve; 47. Connecting pipe A; 48. Connecting pipe B; 49. Heating wire; 50. Fan blade. DETAILED DESCRIPTION

[0046] To make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be described clearly and completely in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them.

[0047] Example:

[0048] like Figure 1-9As shown, a biopharmaceutical detection device proposed in this embodiment includes a box body 1, a driving assembly is arranged on the top wall of the box body 1, a pump 34 is also fixedly connected to the top wall of the box body 1, a base 20 is arranged on the inner wall of the box body 1, a triangular connecting plate 19 is fixedly connected to the end of the base 20 away from the box body 1, a fixed gear 21 is fixedly connected to the outer wall of the base 20, a partition plate 26 is fixedly connected to the inner wall of the box body 1, a mounting plate 8 is fixedly connected to the top wall of the box body 1, a multifunctional box 9 is fixedly connected to the top wall of the mounting plate 8, a heating wire 49 is fixedly connected to the inner wall of the multifunctional box 9, a culture dish 24 is slidably connected to the inner wall of the base 20, and also includes:

[0049] The cleaning assembly includes a rotating column 10 connected to the output end of the driving assembly, one end of the rotating column 10 passes through the box 1 and is connected to a symmetrically distributed extension tube 13, one end of the extension tube 13 away from the rotating column 10 is rotatably connected to a rotating tube 14, the outer wall of the rotating tube 14 is fixedly connected to a uniformly distributed nozzle 15, the outer wall of the rotating tube 14 is provided with a driven gear 22 meshing with a fixed gear 21, and the outer wall of the rotating column 10 is fixedly connected to a driven bevel gear B39;

[0050] The collecting cone 27 is fixedly connected to the inner wall of the box body 1, the outer wall of the collecting cone 27 is fixedly connected to the classification pipe 28, the inner wall of the classification pipe 28 is fixedly connected to the vertical pipe 31, and the vertical pipe 31 is fixedly connected to the base 20;

[0051] A three-way ball valve 46, whose input end is connected to the pump 34, and whose output end is respectively connected to the rotating column 10 and the multi-function box 9, the three-way ball valve 46 is fixedly connected to the top wall of the box body 1, a connecting pipe A47 is fixedly connected to the outer wall of the three-way ball valve 46, and one end of the connecting pipe A47 away from the three-way ball valve 46 is rotatably connected to the rotating column 10, a connecting pipe B48 is fixedly connected to the outer wall of the three-way ball valve 46, and one end of the connecting pipe B48 away from the three-way ball valve 46 is fixedly connected to the multi-function box 9;

[0052] A scraping assembly is arranged on the outer wall of the rotating column 10;

[0053] The filter thermostatic component is arranged on the outer wall of the multifunctional box 9, and the filter thermostatic component and the scraping component are matched with the cleaning component;

[0054] The classification component is arranged on the inner wall of the box body 1.

[0055] like Figure 3-5As shown, as a preferred embodiment, on the basis of the above-mentioned method, further, the scraping assembly includes a driving plate 11 fixedly connected to the outer wall of the rotating column 10, the outer wall of the driving plate 11 is fixedly connected with a symmetrically distributed scraper 12, and the outer wall of the scraper 12 is against the inner wall of the box body 1, the scraper 12 is rotatably connected to the rotating tube 14, and the end of the scraper 12 away from the driving plate 11 is fixedly connected with a positioning ring 23, and the positioning ring 23 is rotatably connected to the base 20. After use, the liquid and impurities attached to the inner wall of the box body 1 can be rotated by the scraper 12 following the rotating column 10, and the inner wall of the box body 1 is scraped by the scraper 12. With the help of the sterilizing liquid, the inner wall of the box body 1 can be quickly cleaned, which is convenient for the next step of detection.

[0056] like Figure 7-8 As shown, as a preferred embodiment, on the basis of the above-mentioned method, further, the driving assembly includes a driving motor 32 fixedly connected to the top wall of the box body 1, the output end of the driving motor 32 cooperates with the cleaning assembly, the output end of the driving motor 32 is fixedly connected to a driving bevel gear A35, the outer wall of the driving bevel gear A35 is rotatably connected to a bevel gear box 33, the inner wall of the bevel gear box 33 is also rotatably connected to a linkage rod 36, the outer wall of the linkage rod 36 is fixedly connected to a driven bevel gear A37, and the outer wall of the driven bevel gear A37 is meshed and connected with the outer wall of the driving bevel gear A35, and the linkage rod 36 is fixedly connected to the outer wall of the driven bevel gear A37. The outer wall of the driving bevel gear B38 is fixedly connected, and the outer wall of the driving bevel gear B38 is meshed with the outer wall of the driven bevel gear B39, and the driving bevel gear A35 is driven to rotate through the output end of the driving motor 32, and then the meshing driven bevel gear B39 is rotated, thereby driving the linkage rod 36 to rotate, and the driving bevel gear B38 is driven to rotate through the linkage rod 36, and then the meshing driven bevel gear B39 is rotated, and further, the driven bevel gear C40 is meshed and driven by the driven bevel gear B39 to rotate, thereby realizing the rotation of the driven rod 41.

[0057] like Figure 5-9As shown, as a preferred embodiment, on the basis of the above-mentioned method, further, the filter thermostatic component includes a filter box 42 fixedly connected to the outer wall of the multifunctional box 9, the inner wall of the filter box 42 is fixedly connected with a uniformly distributed strong tension spring 45, the end of the strong tension spring 45 away from the filter box 42 is fixedly connected with a filter plate 43, the inner wall of the filter plate 43 is rotatably connected with an extrusion plate 44, the inner wall of the extrusion plate 44 is fixedly connected with a driven rod 41, the outer wall of the driven rod 41 is fixedly connected with uniformly distributed fan blades 50, the driven rod 41 cooperates with the output end of the driving component, the outer wall of the driven rod 41 is fixedly connected with a driven bevel gear C40, and the outer wall of the driven bevel gear C40 is meshed and connected with the outer wall of the driven bevel gear B39, when the driven rod When 41 rotates, it drives the fan blades 50 to rotate to form exhaust, and the exhaust passes through the filter plate 43 to filter the dust in the air. At the same time, the rotation of the driven rod 41 drives the extrusion plate 44 to rotate. The center point of the extrusion plate 44 is not at the same position as the connection point of the driven rod 41. Therefore, when the extrusion plate 44 follows the rotation of the driven rod 41, it squeezes and pushes the filter plate 43 to move repeatedly in the filter box 42, and cooperates with the strong tension spring 45 to pull the filter plate 43 to achieve the vibration of the filter plate 43, thereby preventing the filter plate 43 from being blocked and reducing the cleaning frequency, thereby filtering impurities in the air, and at the same time, it can make particles or pollutants pass through its filter plate 43 more effectively, thereby improving the efficiency of the entire filtering process.

[0058] like Figure 5-6 As shown, as a preferred embodiment, on the basis of the above-mentioned method, further, the classification component includes a classification plate 16 rotatably connected to the inner wall of the box body 1, the outer wall of the classification plate 16 is fixedly connected with evenly distributed driving handles 17, the top wall of the classification plate 16 is provided with evenly distributed classification grooves 29, the outer wall of the classification plate 16 is provided with evenly distributed through holes B30, the classification plate 16 is rotatably connected to the vertical tube 31, and the excess sterilization liquid will flow into the collection cone plate 27 through the groove formed at the connection between the triangular connecting plate 19, the box body 1 and the base 20, and flow into the classification groove 29 of the classification plate 16 through the classification pipe 28. The classification groove 29 can classify the substances formed inside the equipment during the microbial culture process, which is convenient for subsequent classification processing, and the collected waste liquid is discharged through the through holes B30 and through holes A18 through the rotating classification plate 16.

[0059] like Figure 1 As shown, as a preferred embodiment, on the basis of the above-mentioned method, further, the outer wall of the box body 1 is fixedly connected with two groups of rotating seats 4, the outer walls of the two groups of rotating seats 4 are fixedly connected with rotating plates 5, the end of the rotating plate 5 away from the rotating seat 4 is fixedly connected with a box door 6, and the outer wall of the box door 6 is fixedly connected with a pulling handle 7, and the box door 6 is driven to rotate on the rotating seat 4 through the pulling handle 7.

[0060] like Figure 5-6As shown, as a preferred embodiment, on the basis of the above-mentioned method, further, a through hole A18 is opened on the outer wall of the box body 1, and the positions of the through hole A18 and the through hole B30 correspond to each other, and the through hole A18 and the through hole B30 are convenient for the waste liquid to flow out.

[0061] like Figure 3 As shown, as a preferred embodiment, on the basis of the above-mentioned method, further, the inner wall of the box body 1 and the inner wall of the base 20 are fixedly connected with a feeding tube 25, through which the culture solution or the drug solution can be added.

[0062] like Figure 1 As shown, as a preferred embodiment, on the basis of the above method, further, the outer wall of the box body 1 is fixedly connected with a symmetrically distributed support frame 2, and the end of the support frame 2 away from the box body 1 is fixedly connected with a support plate 3, and the equipment is supported by the support frame 2 and the support plate 3.

[0063] Specifically, when the biopharmaceutical detection device and method are used: the drive motor 32 is started, and the drive bevel gear A35 is driven to rotate through the output end of the drive motor 32, and then the meshing driven bevel gear B39 is rotated, thereby driving the linkage rod 36 to rotate, and the drive bevel gear B38 is driven to rotate through the linkage rod 36, and then the meshing driven bevel gear B39 is rotated, and further, the driven bevel gear B39 is meshed with the driven bevel gear C40 to rotate, thereby realizing the rotation of the driven rod 41. At this point, when the driven rod 41 rotates, it drives the fan blades 50 to rotate to form exhaust, and the exhaust passes through the filter plate 43 to filter the dust in the air, and at the same time, the rotation of the driven rod 41 drives the extrusion plate 44 to rotate. The center point of the extrusion plate 44 is not at the same position as the connection point of the driven rod 41. Therefore, when the extrusion plate 44 rotates following the driven rod 41, it will squeeze and push the filter plate 43 to move repeatedly in the filter box 42, and cooperate with the strong tension spring 45 to pull the filter plate 43 to achieve the vibration of the filter plate 43, thereby preventing the filter plate 43 from being blocked and reducing the cleaning frequency, thereby filtering impurities in the air, and at the same time allowing particles or pollutants to pass through its filter plate 43 more effectively, thereby improving the efficiency of the entire filtering process; when the exhaust air is formed and filtered, its three-way ball valve 46 rotates a certain angle, so that both the pump 34 and the exhaust air can enter the connecting pipe B48 through the three-way ball valve 46, and the pump 34 is externally connected to the sterilizing liquid, and the mixed filtered air passes through the connecting pipe B48. The connecting pipe B48 flows into the rotating column 10, and the connection between the rotating column 10 and the connecting pipe B48 is a mechanical seal rotating connection to prevent leakage of gas or liquid. The mixed sterilizing gas will be ejected through the extension pipe 13, the rotating pipe 14 and the nozzle 15. When the driven bevel gear B39 rotates, it drives the rotating column 10 to rotate, and then drives the extension pipe 13 and the rotating pipe 14 to rotate, and then drives the driven bevel gear 22 to rotate. When the driven bevel gear 22 rotates, it will mesh with the fixed gear 21, thereby rotating, that is, the rotating pipe 14 and the nozzle 15 rotate, thereby realizing the revolution and rotation of the nozzle 15, ensuring that the internal area is sterilized without dead angles, and facilitating the improvement of the accuracy of detection or cultivation; the excess sterilizing liquid will pass through the triangular connecting plate 19, the box body 1 and The groove formed at the connection of the base 20 flows into the collecting cone 27, and flows into the classification groove 29 of the classification plate 16 through the classification pipe 28. The classification groove 29 can classify the substances formed inside the equipment during the microbial culture process, which is convenient for subsequent classification processing, and the collected waste liquid is discharged through the through hole B30 and the through hole A18 of the rotating classification plate 16; when the inside of the box 1 is cleaned, the culture liquid and the drug to be detected are added through the feeding pipe 25, the drug is the drug to be detected, and the culture liquid is the culture liquid used by the microorganisms, so that the microorganisms can cooperate in a sterile environment, and after the culture is completed, it is mixed with the drug for detection. Since the microorganisms are always sterilely cultured in the box 1, the influence of bacteria is fundamentally eliminated, and the accuracy of the detection is improved;During the microorganism cultivation process, the fan blades 50 rotate all the time to ensure the ventilation effect inside the box 1. At the same time, the heating wire 49 can be heated, so as to heat the circulating air and provide a suitable temperature for microorganism cultivation. At the same time, the heated air is distributed in a rotating manner through the nozzle 15, so as to increase the temperature inside the box 1 more quickly and improve the cultivation efficiency of microorganisms. After use, the liquid and impurities attached to the inner wall of the box 1 can be rotated by the scraper 12 following the rotating column 10, and the inner wall of the box 1 can be scraped off by the scraper 12. With the sterilizing liquid, the inner wall of the box 1 can be quickly cleaned, which is convenient for the next step of detection, and the drying function can be realized by the heated air. At this time, the three-way ball valve 46 can be flexibly adjusted to realize the function of spraying liquid disinfection or drying the nozzle 15, which is flexible and multi-purpose. ;

[0064] The above embodiments are only used to illustrate the present invention and are not intended to limit the technical solutions described in the present invention. Although the present invention has been described in detail with reference to the above embodiments, the present invention is not limited to the above specific implementation methods. Therefore, any modification or equivalent replacement of the present invention; and all technical solutions and improvements thereof that do not depart from the spirit and scope of the invention are included in the scope of the claims of the present invention.

Claims

1. A biopharmaceutical detection device, comprising a housing (1), characterized in that: The top wall of the box body (1) is provided with a driving assembly, the top wall of the box body (1) is also fixedly connected to a pump (34), the inner wall of the box body (1) is provided with a base (20), the outer wall of the base (20) is fixedly connected to a fixed gear (21), and further comprises: A cleaning assembly, the cleaning assembly comprising a rotating column (10) connected to an output end of a driving assembly, one end of the rotating column (10) passing through a housing (1) and connected to symmetrically distributed extension tubes (13), one end of the extension tube (13) away from the rotating column (10) being rotatably connected to a rotating tube (14), an outer wall of the rotating tube (14) being fixedly connected to uniformly distributed nozzles (15), and a driven gear (22) meshingly connected to a fixed gear (21) being arranged on the outer wall of the rotating tube (14); A collecting cone (27) is fixedly connected to the inner wall of the box body (1); A three-way ball valve (46), the input end of which is connected to the pump (34), and the output end of which is respectively connected to the rotating column (10) and the multifunctional box (9); A scraping component is arranged on the outer wall of the rotating column (10); A filtering thermostatic component is arranged on the outer wall of the multifunctional box (9), and the filtering thermostatic component and the scraping component are both matched with the cleaning component; The classification component is arranged on the inner wall of the box body (1).

2. A biopharmaceutical detection device according to claim 1, characterized in that: The scraping assembly comprises a driving plate (11) fixedly connected to the outer wall of a rotating column (10); the outer wall of the driving plate (11) is fixedly connected with symmetrically distributed scrapers (12); and the outer walls of the scrapers (12) abut against the inner wall of the box body (1).

3. A biopharmaceutical detection device according to claim 1, characterized in that: The driving assembly comprises a driving motor (32) fixedly connected to the top wall of the box body (1), and the output end of the driving motor (32) cooperates with the cleaning assembly.

4. A biopharmaceutical detection device according to claim 1, characterized in that: The filtering thermostatic assembly comprises a filtering box (42) fixedly connected to the outer wall of the multifunctional box (9); the inner wall of the filtering box (42) is fixedly connected with evenly distributed strong tension springs (45); one end of the strong tension spring (45) away from the filtering box (42) is fixedly connected with a filtering plate (43); the inner wall of the filtering plate (43) is rotatably connected with an extrusion plate (44); the inner wall of the extrusion plate (44) is fixedly connected with a driven rod (41); the outer wall of the driven rod (41) is fixedly connected with evenly distributed fan blades (50); and the driven rod (41) cooperates with the output end of the driving assembly.

5. A biopharmaceutical detection device according to claim 1, characterized in that: The classification component comprises a classification plate (16) rotatably connected to the inner wall of the box body (1), the outer wall of the classification plate (16) is fixedly connected with evenly distributed driving handles (17), the top wall of the classification plate (16) is provided with evenly distributed classification grooves (29), and the outer wall of the classification plate (16) is provided with evenly distributed through holes B (30).

6. A biopharmaceutical detection device according to claim 1, characterized in that: The outer wall of the box body (1) is fixedly connected to two groups of rotating seats (4), the outer walls of the two groups of rotating seats (4) are fixedly connected to rotating plates (5), one end of the rotating plate (5) away from the rotating seat (4) is fixedly connected to a box door (6), and the outer wall of the box door (6) is fixedly connected to a pulling handle (7).

7. A biopharmaceutical detection device according to claim 1, characterized in that: The outer wall of the box body (1) is provided with a through hole A (18), and the positions of the through hole A (18) and the through hole B (30) correspond to each other.

8. A biopharmaceutical detection device according to claim 1, characterized in that: The inner wall of the box body (1) and the inner wall of the base (20) are both fixedly connected with a feeding pipe (25).

9. A biopharmaceutical detection device according to claim 1, characterized in that: The outer wall of the box body (1) is fixedly connected to symmetrically distributed support frames (2), and one end of the support frame (2) away from the box body (1) is fixedly connected to a support plate (3).

10. A method for detecting biopharmaceuticals, characterized in that: The following steps are involved: S1. When the driven rod (41) rotates, the fan blade (50) is driven to rotate to form exhaust. The exhaust passes through the filter plate (43) to filter dust in the air. At the same time, the rotation of the driven rod (41) drives the extrusion plate (44) to rotate. The center point of the extrusion plate (44) and the connection point of the driven rod (41) are not at the same position. Therefore, when the extrusion plate (44) rotates following the driven rod (41), it squeezes and pushes the filter plate (43) to move repeatedly in the filter box (42). With the pulling force of the strong tension spring (45) on the filter plate (43), the filter plate (43) is vibrated, thereby preventing the filter plate (43) from being blocked and reducing the cleaning frequency, thereby filtering impurities in the air and allowing particles or pollutants to pass through the filter plate (43) more effectively, thereby improving the efficiency of the entire filtering process; S2. When the exhaust air is formed and filtered, the pump (34) is connected to the sterilizing liquid, and the three-way ball valve (46) is rotated at a certain angle to cooperate with the pump (34) and the exhaust air to transport the mixed and filtered air into the rotating column (10) to prevent leakage of gas or liquid. The mixed sterilizing gas will be ejected through the extension tube (13), the rotating tube (14) and the nozzle (15). When the rotating column (10) rotates, it will drive the extension tube (13) and the rotating tube (14) to rotate, and then drive the driven gear (22) to rotate. When the driven gear (22) rotates, it will mesh with the fixed gear (21) to rotate, that is, the rotating tube (14) and the nozzle (15) rotate, so as to realize the revolution and rotation of the nozzle (15), ensuring that the internal area is sterilized without dead angles, so as to improve the accuracy of detection or cultivation; S3, the excess sterilizing liquid will eventually flow into the classification groove (29) of the classification plate (16), and the classification groove (29) can classify the substances formed inside the device during the microbial cultivation process, which is convenient for subsequent classification treatment, and the collected waste liquid is discharged through the through hole B (30) and the through hole A (18) of the classification plate (16) by rotating the classification plate (16); S4. After the interior of the box (1) is cleaned, a culture solution and a drug to be detected are added through the feeding pipe (25). The drug is the drug to be detected, and the culture solution is a culture solution used by microorganisms, so that the microorganisms can cooperate in a sterile environment. After the culture is completed, the mixture is mixed with the drug for detection. Since the microorganisms are always sterilely cultured in the box (1), the influence of bacteria is fundamentally eliminated, thereby improving the accuracy of detection; S5. After use, the liquid and impurities attached to the inner wall of the box body 1 can be rotated by the scraper (12) following the rotating column (10), and the scraper (12) can scrape the inner wall of the box body (1). With the help of the sterilizing liquid, the inner wall of the box body (1) can be quickly cleaned, which is convenient for the next step of detection. The drying function can be achieved by the heated air. At this time, the three-way ball valve (46) can be flexibly adjusted to achieve the function of spraying liquid disinfection or drying of the nozzle (15), which is flexible and versatile.

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