SAM类似物及其应用
By constructing a cyclic enzyme cascade reaction of a SAM-dependent methyltransferase mutant and a fluoroalkyl SAM analog, the efficiency and stability issues of the fluoroethylation reaction were solved, achieving high-yield fluoroalkylation modification and providing an environmentally friendly synthetic method.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- TIANJIN UNIV
- Filing Date
- 2024-03-07
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies are difficult to efficiently carry out fluoroalkylation reactions, especially fluoroethylation reactions, and traditional chemical synthesis methods suffer from environmental unfriendliness, poor selectivity, and low yield.
Using a SAM-dependent methyltransferase mutant and fluoroalkyl SAM analogs, an HMT-MTase cyclic enzyme cascade system was constructed. Fluoroalkylation was carried out via enzymatic synthesis, and SAM analogs FEt-SeAM and FEt-SAM were used as fluoroalkyl group donors to perform fluoroethylation modification of O-, N-, S- and C- nucleophiles.
This method improves the product yield of the fluoroethylation reaction, avoids the elimination problem of fluoroethyl groups, enhances the stability and efficiency of the reaction, and provides an environmentally friendly synthetic route.
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