A staining analysis device for pathological diagnosis

Abstract

The present invention discloses a staining analysis device for pathological diagnosis, specifically relating to the field of staining of pathological diagnosis sections, including: a housing and a staining bracket. A plurality of staining pools are arranged inside the housing. Each staining pool includes a staining solution box and a rinsing box. A plurality of glass slides are vertically placed on the staining bracket, and sections are fixed on the surfaces of the plurality of glass slides. A bracket driving mechanism is further arranged inside the housing, and the bracket driving mechanism is used to place the staining bracket in the staining pool. By providing an expandable staining bracket, the staining bracket equipped with sections is expanded when placed in the rinsing box, and the swinging angle of the sections is in an inclined state, which can facilitate observing the water flow direction and rinsing degree during the rinsing process, is convenient for controlling the staining effect during the water washing process, and at the same time enables the water flow to slide down along the inclined surface of the sections, reducing the over-strong scouring of a certain local area on the section surface and avoiding excessive loss of dyes in the local area.

Description

Technical Field

[0001] The present invention relates to the technical field of pathological diagnosis section staining, and more specifically, the present invention relates to a staining analysis device for pathological diagnosis. Background Art

[0002] Pathological diagnosis staining is an important step in histological and pathological analysis. By staining, the contrast of tissue sections can be enhanced, thus helping pathologists observe and judge diseases. The HE staining method (hematoxylin-eosin staining method) is a widely used staining technique in pathology and histology for observing the structure and cell morphology of tissue sections. It is one of the most commonly used staining methods and can clearly show the morphological characteristics of cell nuclei and cytoplasm, as well as the basic structure and pathological changes of tissues.

[0003] Currently, the staining steps for sections during pathological diagnosis include placing the sections in hematoxylin and eosin staining solutions for staining. In hematoxylin staining, after hematoxylin staining, the sections need to be rinsed with distilled water to remove residual hematoxylin, then placed in hydrochloric acid alcohol solution for differentiation. After differentiation, they are rinsed with distilled water to remove residual hydrochloric acid alcohol, then placed in ammonia water for bluing. After bluing, they are rinsed with distilled water again, and then placed in basic fuchsin solution for restaining. After restaining, they are rinsed with distilled water to remove residual basic fuchsin, and then finally eosin staining is carried out. After the staining is completed, they are rinsed with distilled water to remove residual eosin, including multiple rinses of the sections.

[0004] Currently, in the actual use process of pathological diagnosis, in order to efficiently stain multiple sections, a professionally designed section staining rack (also called a staining carrier or staining basket) is usually used. Multiple glass slides are neatly inserted into the staining carrier, and a certain distance is maintained between each glass slide so that the staining solution can fully contact the surface of the sections without adhesion or affecting the staining uniformity. The distance also needs to be set smaller to facilitate staining multiple sections simultaneously to improve the staining efficiency. Since the distance between multiple sections is relatively close, it is necessary to take out the sections multiple times during rinsing to observe the staining effect of the sections to avoid over-rinsing, resulting in over-rinsing or under-rinsing of the staining of cell nuclei and cytoplasm, ultimately weakening the overall staining effect of the sections and reducing the contrast between the cell nucleus and cytoplasm, which is not conducive to microscopic observation. However, during the staining process, multiple rinses are usually required. During multiple rinses and the multiple rinsing process, the sections need to be taken out multiple times to observe the staining situation, which will cause problems affecting the staining efficiency. Summary of the Invention

[0005] A staining analysis device for pathological diagnosis provided by the present invention aims to solve the following problem: In order to ensure the staining efficiency, multiple slices are placed on the existing staining bracket for simultaneous staining. However, the distance between adjacent two slices is relatively small, resulting in the need to take out the slices multiple times during rinsing to observe the staining effect of the slices, so as to avoid over-rinsing. Furthermore, this will affect the staining efficiency due to taking out the slices multiple times to observe the staining effect.

[0006] To achieve the above object, the present invention provides the following technical solution: A staining analysis device for pathological diagnosis, characterized by comprising: a housing, a staining bracket, a sliding driving mechanism, and a rinsing component. A plurality of staining pools are arranged inside the housing. The staining pool includes a staining solution box and a rinsing box. A bracket driving mechanism for driving the movement of the staining bracket is also arranged inside the housing;

[0007] A plurality of support components are arranged on the staining bracket. The support component includes a fixed frame and two sliding frames. The fixed frame is fixedly arranged on the staining bracket, and the sliding frame is slidably arranged on the staining bracket. Placement frames for placing glass slides are hingedly arranged on both the fixed frame and the sliding frame;

[0008] A plurality of pushing members and toggling members are slidably arranged inside the staining bracket. The sliding driving mechanism is used to drive the pushing members and the toggling members to slide, so that a plurality of pushing members push two adjacent sliding frames to slide out of the staining bracket in opposite directions, and a plurality of toggling members toggle the plurality of placement frames to swing angles.

[0009] In a preferred embodiment, a sliding seat is slidably arranged inside the staining bracket. A plurality of pushing members and toggling members are fixedly arranged on the sliding seat. Guide openings are formed at the bottoms of a plurality of sliding frames. The guide openings are inclined. The pushing members are movably connected inside the guide openings, and the inclination directions of the guide openings formed at the bottoms of two adjacent sliding frames are opposite.

[0010] In a preferred embodiment, a rubber pad is fixedly arranged on the placement frame. The rubber pad is used to fix the glass slide on the placement frame. Side holes are formed on the sides of a plurality of placement frames. The toggling members are movably arranged inside the side holes.

[0011] In a preferred embodiment, the sliding driving mechanism is a first sliding driving component. The first sliding driving component includes a resisting block. The resisting block is fixedly arranged on the inner bottom wall of the rinsing box, and the top end of the resisting block is inclined. An opening is formed at the bottom of the staining bracket. A resisting groove is formed at the bottom of the sliding seat. The inner top wall of the resisting groove is inclined, and the inclination angles of the top end of the resisting block and the inner top wall of the resisting groove are the same. An elastic member I is fixedly arranged on one side of the sliding seat. The end of the elastic member I away from the sliding seat is fixedly arranged on the staining bracket.

[0012] In a preferred embodiment, a first sliding rod is fixedly arranged on the other side of the sliding seat. The first sliding rod is slidably arranged in the dyeing bracket, and a first limiting block is fixedly arranged on the first sliding rod. The first limiting block is in movable contact with the dyeing bracket.

[0013] In a preferred embodiment, the sliding driving mechanism is a second sliding driving component. The second sliding driving component includes a driving member. The driving member is fixedly installed on the dye solution box. The output end of the driving member extends into the dye solution box, and a push rod is fixedly arranged. Elastic members II and second sliding rods are respectively fixedly arranged on both sides of the sliding seat. The second sliding rods are slidably arranged in the dyeing bracket. Second limiting blocks are fixedly arranged on the second sliding rods. The second limiting blocks are in movable contact with the dyeing bracket. A bottom groove is formed at the bottom of the second sliding rod. The push rod is located in the bottom groove, and the push rod is in movable contact with the inner wall of the bottom groove.

[0014] In a preferred embodiment, the bracket driving mechanism includes a first linear driving component, a second linear driving component and a clamping component. The clamping component is used for clamping the dyeing bracket. The second linear driving component is installed at the output end of the first linear driving component. The clamping component is installed at the output end of the second linear driving component. The second linear driving component is used for driving the dyeing bracket to move in a vertical linear direction. The first linear driving component is used for driving the dyeing bracket to move in a horizontal linear direction.

[0015] In a preferred embodiment, the clamping component includes a housing. The housing is fixedly installed at the output end of the second linear driving component. A power component is installed in the housing. The output end of the power component is installed with a gear. Two racks are slidably arranged in the housing. The adjacent sides of the two racks are both meshed with the gear. Clamping seats are fixedly arranged on both racks. Positioning shafts are installed on both clamping seats. A top frame is installed on the dyeing bracket. Positioning holes are formed in the top frame. The positioning shafts are adapted to the positioning holes.

[0016] In a preferred embodiment, a mobile flushing mechanism is further arranged in the machine housing. The mobile flushing mechanism includes a third linear driving component and a fourth linear driving component. The fourth linear driving component is installed at the output end of the third linear driving component. A flushing component is installed at the output end of the fourth linear driving component. The third linear driving component is used for driving the flushing component to move in a left-right horizontal linear direction. The fourth linear driving component is used for driving the flushing component to move in a front-back horizontal linear direction.

[0017] In a preferred embodiment, the flushing component includes a water pump. The water pump is installed at the output end of the fourth linear driving component. The water outlet end of the water pump is installed with a flushing pipe. The output end of the flushing pipe points to the section.

[0018] The beneficial effects of the present invention are as follows:

[0019] By providing an expandable staining carrier, the staining carrier with sections thereon expands when placed in the rinsing box, and the swinging angle of the sections is in an inclined state, which can facilitate observing the water flow direction and rinsing degree during the rinsing process, facilitate controlling the staining effect during the water washing process, and at the same time enable the water flow to slide down along the inclined surface of the sections, reducing the over-intense scouring of a certain local part of the section surface and avoiding excessive loss of dyes locally. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a three-dimensional structural schematic diagram of the present invention.

[0021] Figure 2 It is a three-dimensional structural schematic diagram of the carrier driving mechanism and multiple groups of staining pools of the present invention.

[0022] Figure 3 It is a three-dimensional structural schematic diagram of the staining carrier and the clamping assembly of the present invention.

[0023] Figure 4 It is a three-dimensional structural schematic diagram of the staining carrier of the present invention.

[0024] Figure 5 It is a schematic diagram of the expanded state of the staining carrier of the present invention.

[0025] Figure 6 It is a partial three-dimensional structural schematic diagram of the staining carrier of the present invention.

[0026] Figure 7 It is a three-dimensional schematic diagram of the sliding seat of the present invention.

[0027] Figure 8 It is a three-dimensional schematic diagram of the sliding frame at different angles of the present invention.

[0028] Figure 9 It is a schematic diagram of the state of the sliding frame after the staining carrier is expanded of the present invention.

[0029] Figure 10 It is a schematic diagram of the expansion process of the sliding frame of the present invention.

[0030] Figure 11 It is a schematic diagram of the swinging state of the placement rack of the present invention.

[0031] Figure 12 It is a sectional structural schematic diagram of the first sliding drive assembly of the present invention Figure 1 .

[0032] Figure 13 It is a sectional structural schematic diagram of the first sliding drive assembly of the present invention Figure 2 .

[0033] Figure 14 It is a sectional structural schematic diagram of the second sliding drive assembly of the present invention.

[0034] Figure 15 Explosion diagram of the clamping component of the present invention.

[0035] Figure 16 Schematic three-dimensional structure diagram of the mobile flushing mechanism of the present invention.

[0036] Figure 17 is Figure 12 Enlarged view of part A in

[0037] Figure 18 is Figure 14 Enlarged view of part B in

[0038] Reference numerals are: 1, housing; 11, dyeing tank; 111, dye solution box; 112, flushing box; 2, dyeing bracket; 21, top bracket; 211, positioning hole; 22, support assembly; 221, fixing bracket; 222, sliding bracket; 2221, guiding opening; 23, placing bracket; 231, rubber pad; 232, side hole; 24, sliding seat; 241, pushing member; 242, toggling member; 25, first sliding driving assembly; 251, abutting block; 252, opening; 253, abutting groove; 254, first elastic member; 255, first sliding rod; 256, first limiting block; 3, glass slide; 31, section; 4, bracket driving mechanism; 41, first linear driving assembly; 42, second linear driving assembly; 43, clamping assembly; 431, housing; 432, power component; 433, gear; 434, rack; 435, clamping seat; 436, positioning shaft; 5, mobile flushing mechanism; 51, third linear driving assembly; 52, fourth linear driving assembly; 53, flushing assembly; 531, water pump; 532, flushing pipe; 6, second sliding driving assembly; 61, driving member; 62, push rod; 63, second elastic member; 64, second sliding rod; 641, bottom groove; 65, second limiting block. Detailed implementation manners

[0039] The following further describes the present application in detail with reference to the accompanying drawings. It is necessary to point out here that the following specific implementation manners are only used to further illustrate the present application and cannot be understood as limiting the protection scope of the present application. Those skilled in the art can make some non-essential improvements and adjustments to the present application according to the above application content.

[0040] Refer to the attached drawings of the specification Figures 1 to 18, A staining analysis device for pathological diagnosis, comprising: a housing 1 and a staining bracket 2. A plurality of staining pools 11 are arranged in the housing 1, and the plurality of staining pools 11 are evenly arranged in a linear array in the housing 1. The staining pool 11 includes a dye solution box 111 and a rinsing box 112. A plurality of slides 3 arranged in a linear array are evenly placed on the staining bracket 2. Sections 31 are fixed on the surfaces of the plurality of slides 3. A bracket driving mechanism 4 is further arranged in the housing 1, and the bracket driving mechanism 4 is used to place the staining bracket 2 in the staining pool 11 to stain and rinse the sections 31;

[0041] A plurality of support assemblies 22 are arranged on the staining bracket 2, and the plurality of support assemblies 22 are evenly arranged in a linear array on the staining bracket 2. The support assembly 22 includes a fixed frame 221 and two sliding frames 222. The fixed frame 221 is fixedly arranged on the staining bracket 2, and the sliding frame 222 is slidably arranged on the staining bracket 2. Placement frames 23 are hinged on both the fixed frame 221 and the sliding frame 222, and the slides 3 are placed on the placement frames 23;

[0042] A sliding seat 24 is slidably arranged in the staining bracket 2. A plurality of pushing members 241 and toggling members 242 are fixedly arranged on the sliding seat 24. The plurality of pushing members 241 are movably arranged in the corresponding sliding frames 222, and the plurality of toggling members 242 are movably arranged in the corresponding placement frames 23. The staining analysis device further includes a sliding driving mechanism, and the sliding driving mechanism is used to drive the sliding seat 24 to slide, so that the plurality of pushing members 241 push the adjacent two sliding frames 222 to slide out of the staining bracket 2 in opposite directions, and the plurality of toggling members 242 toggle the plurality of placement frames 23 to swing angles;

[0043] A rinsing assembly 53 is further arranged in the housing 1, and the rinsing assembly 53 is used to flush water to the sections 31.

[0044] It should be noted that a plurality of sliding openings are formed on the staining bracket 2, and the plurality of sliding frames 222 are slidably arranged in the corresponding sliding openings. Ball bearings can be arranged on both sides of the sliding frame 222. By the rolling contact of the ball bearings with the inner wall of the sliding opening, the friction force during the sliding of the sliding frame 222 is reduced, which is beneficial to the sliding of the sliding frame 222. The bracket driving mechanism 4 can include a linear motor and a pneumatic gripper structure. The staining bracket 2 is clamped by the pneumatic gripper structure, and the staining bracket 2 is driven by the linear motor to move and extend into the dye solution box 111 or the rinsing box 112 to achieve the staining and rinsing of the sections 31. The sliding driving mechanism can adopt a cylinder to drive the sliding seat 24 to slide, so that when the cylinder drives the sliding seat 24 to move, the pushing members 241 and the toggling members 242 move synchronously.

[0045] The driving member 241 is a push shaft, and guide openings 2221 are formed at the bottoms of the plurality of sliding brackets 222. The guide openings 2221 are inclined. The driving member 241 is movably connected in the guide openings 2221. Refer to the appended drawings of the specification Figure 10 The direction of arrow a is the moving direction of the driving member 241, and the direction of arrow b is the moving direction of the two sliding brackets 222. The inclination directions of the guide openings 2221 formed at the bottoms of two adjacent sliding brackets 222 are opposite. When the movement of the slide base 24 drives the driving member 241 to move, the two driving members 241 can move in the corresponding guide openings 2221, so that the two driving members 241 can push the two sliding brackets 222 to move in opposite directions, and the two sliding brackets 222 are extended out of the staining bracket 2, and the sections 31 on the sliding brackets 222 can be pushed out of the staining bracket 2.

[0046] A rubber pad 231 is fixedly arranged on the placement rack 23. The rubber pad 231 is used to fix the glass slide 3 on the placement rack 23. When placing the glass slide 3, the glass slide 3 can be placed in the rubber pad 231, and the glass slide 3 is fixed by the rubber pad 231. The toggling member 242 is a toggling shaft, and side holes 232 are formed on the sides of the plurality of placement racks 23. The toggling member 242 is movably arranged in the side holes 232. Refer to the appended drawings of the specification Figure 11 The direction of arrow c is the moving direction of the toggling member 242, and the direction of arrow d is the swinging direction of the placement rack 23. When the movement of the slide base 24 drives the toggling member 242 to move, since the placement rack 23 is hinged and the toggling member 242 is movably arranged in the side holes 232, during the movement of the toggling member 242, the toggling member 242 can toggle the placement rack 23 to swing, so that the glass slide 3 arranged on the placement rack 23 swings synchronously.

[0047] It should be noted that the side holes 232 are formed through the placement rack 23, and the toggling member 242 also passes through the side holes 232. When two adjacent sliding brackets 222 slide out of the staining bracket 2, the toggling member 242 can still be in the side holes 232, so as to ensure that after the sliding brackets 222 slide out of the staining bracket 2, the toggling member 242 can still toggle the placement rack 23 to swing.

[0048] In this embodiment, the real-time scenario is as follows: First, a plurality of glass slides 3 with sections 31 fixed on their surfaces are placed in corresponding placement racks 23, and the glass slides 3 are fixed on the placement racks 23 through the rubber pads 231 provided on the placement racks 23. Then, the staining carrier 2 is placed in the staining solution box 111 by the carrier driving mechanism 4 for staining. After staining, the staining carrier 2 is placed in the rinsing box 112 by the carrier driving mechanism 4. Then, the sliding driving mechanism drives the slide 24 to slide in the staining carrier 2, so that the slide 24 drives the pusher 241 and the toggler 242 to move synchronously, enabling a plurality of pushers 241 to push two adjacent sliding frames 222 to move in opposite directions, slide out of the staining carrier 2, and cause the glass slides 3 placed on the corresponding sliding frames 222 to extend out of the staining carrier 2. At the same time, a plurality of togglers 242 are used to toggle a plurality of placement racks 23 to swing at an angle, so that the glass slides 3 placed on the placement racks 23 can swing at the same angle, and the staining carrier 2 can be unfolded, as Figure 5 shown in the schematic diagram of the state after the staining carrier 2 is unfolded. At this time, after toggling the placement rack 23, the glass slide 3 is in an inclined state, and since the movement of two adjacent sliding frames 222 drives the corresponding glass slides 3 to extend out of the staining carrier 2, the distance between two glass slides 3 in the same horizontal direction can be increased. Due to the increased distance, when the glass slide 3 is inclined, the section 31 on the surface of the glass slide 3 can be exposed, so that during the rinsing process, it is easy to observe the water flow direction and the rinsing degree, facilitating the control of the staining effect during the water washing process. Finally, the section 31 is rinsed by the rinsing assembly 53.

[0049] It should also be noted that since the staining carrier 2 is unfolded and the glass slide 3 is inclined, when the section 31 is rinsed at this time, the water flow slides down along the inclined surface, reducing the over-strong scouring of a certain part of the surface of the section 31, avoiding excessive loss of dye in a local area, and the inclined placement can make the water flow wash the surface of the section 31 more evenly, which helps to maintain the overall staining balance of the section 31.

[0050] Specifically, referring to the attached drawings of the specification Figure 12 and Figure 13 as well as Figure 17, the present invention provides a specific structure of a sliding drive mechanism. The sliding drive mechanism is the first sliding drive assembly 25. The first sliding drive assembly 25 includes a abutting block 251. The abutting block 251 is fixedly arranged on the bottom inner wall of the rinsing box 112, and the top end of the abutting block 251 is inclined. An opening 252 is formed at the bottom of the dyeing bracket 2. Abutting groove 253 is formed at the bottom of the sliding seat 24. The top inner wall of the abutting groove 253 is inclined, and the top end of the abutting block 251 has the same inclination angle as the top inner wall of the abutting groove 253. One side of the sliding seat 24 is fixedly provided with a first elastic member 254. The end of the first elastic member 254 away from the sliding seat 24 is fixedly arranged on the dyeing bracket 2. The other side of the sliding seat 24 is fixedly provided with a first sliding rod 255. The first sliding rod 255 is slidably arranged in the dyeing bracket 2, and a first limiting block 256 is fixedly arranged on the first sliding rod 255. The first limiting block 256 is in movable abutment with the dyeing bracket 2.

[0051] It should be noted that by arranging the abutting block 251 on the bottom inner wall of the rinsing box 112, when the dyeing bracket 2 is placed in the rinsing box 112, the abutting block 251 can extend into the abutting groove 253 through the opening 252. That is, through the abutting block 251 with a beveled top end and the abutting groove 253 with a beveled top inner wall, during the process of placing the dyeing bracket 2 in the rinsing box 112, the abutting block 251 can push the sliding seat 24 to slide, so that when the sliding seat 24 is pushed, the dyeing bracket 2 can be unfolded. Subsequently, the section 31 placed on the dyeing bracket 2 can be directly rinsed. And during the rinsing process, through the unfolded dyeing bracket 2, it is convenient to observe the water flow direction and the rinsing degree effect, which is convenient to control the dyeing effect during the water washing process. At the same time, the section 31 can be in an inclined state, reducing the over-strong scouring of a certain local part of the surface of the section 31, avoiding excessive loss of dye in the local area, and ensuring uniform rinsing of the surface of the section 31, which helps to maintain the overall dyeing balance of the section 31.

[0052] It should also be noted that through the above structure and the first elastic member 254, the first elastic member 254 can be a spring. That is, when the dyeing bracket 2 is taken out of the rinsing box 112, the dyeing bracket 2 can be automatically retracted, so as to facilitate placing the dyeing bracket 2 in the dyeing solution box 111 for further dyeing subsequently.

[0053] It should be further noted that the staining process of the section 31 also includes soaking in anhydrous ethanol of various concentrations. Therefore, multiple soaking pools need to be arranged in the casing 1, and anhydrous ethanol of different concentrations is respectively placed in the multiple soaking pools. In order to save the placement space in the casing 1 and improve the utilization rate, the sizes of the soaking pool and the dye solution box 111 are both smaller than those of the rinsing box 112. Therefore, when staining multiple sections 31 simultaneously, saving the rinsing time and ensuring the staining efficiency, the staining bracket 2 needs to be set to be expandable. When rinsing the section 31, the staining bracket 2 is in an expanded state in the rinsing box 112, so as to facilitate observing the water flow direction and the effect of the rinsing degree.

[0054] Specifically, referring to the attached Figure 14 to Figure 18 , the present invention also provides another specific structure of the sliding driving mechanism. The sliding driving mechanism is the sliding driving assembly two 6. The sliding driving assembly two 6 includes a driving member 61. The driving member 61 is fixedly installed on the dye solution box 111. The output end of the driving member 61 extends into the dye solution box 111 and is fixedly provided with a push rod 62. Elastic members two 63 and sliding rods two 64 are respectively fixedly provided on both sides of the sliding seat 24. The sliding rods two 64 are slidably arranged in the staining bracket 2. A limiting block two 65 is fixedly provided on the sliding rod two 64. The limiting block two 65 is in movable contact with the staining bracket 2. A bottom groove 641 is opened at the bottom of the sliding rod two 64. The push rod 62 is located in the bottom groove 641, and the push rod 62 is in movable contact with the inner wall of the bottom groove 641.

[0055] It should be noted that the driving member 61 can be installed on the side of the dye solution box 111 and the rinsing box 112. The driving member 61 is a cylinder. After placing the staining bracket 2 in the rinsing box 112, at this time, the push rod 62 is driven to move by the cylinder. After the push rod 62 moves to contact the inner wall of the bottom groove 641, the push rod 62 is continuously driven to move, so that the push rod 62 pushes the sliding seat 24 to move, and thus the sliding seat 24 can be driven to move until the staining bracket 2 is expanded.

[0056] It should also be noted that after the staining bracket 2 is placed in the dye solution box 111, at this time, the push rod 62 is driven to move by the air cylinder. When the push rod 62 moves to contact the inner wall of the bottom groove 641, the push rod 62 is driven to move telescopically by the air cylinder. The telescopic movement distance can be determined according to the required swing amplitude of the glass slide 3. And the second elastic member 63 is a spring, so that the reciprocating movement of the sliding seat 24 can be realized under the joint cooperation of the second elastic member 63. Thus, when the sliding seat 24 reciprocates, the glass slide 3 can be toggled to swing reciprocally by the toggling member 242. Then, the section 31 can be driven by the glass slide 3 to slightly shake, so as to help the dye solution cover the surface of the section 31 more evenly, ensure that the dye can be evenly distributed, thereby improving the consistency of staining, and can increase the contact time between the dye and the section 31, making the dye better penetrate into the cells, thereby improving the staining intensity of the cell nucleus and cytoplasm. In addition, it can also help to eliminate air bubbles, ensure that the dye solution can evenly contact the section 31, and avoid uneven local staining caused by air bubbles. However, when the toggling member 242 toggles the swinging angle of the glass slide 3, the pushing member 241 will also push the two adjacent sliding frames 222 to slide out of the staining bracket 2. As a result, the section 31 on the sliding frame 222 will add a lateral movement action. In order to avoid the problem that the section 31 swings while there is also a lateral reciprocating movement action, which disrupts the flow of the dye solution and affects staining, at this time, the diameter of the guiding port 2221 needs to be set larger than the diameter of the pushing member 241, and it is necessary to ensure that during the reciprocating movement of the sliding seat 24, its movement distance will not cause the pushing member 241 to push the sliding frame 222 to move. The specific movement distance of the sliding seat 24, as well as the diameter of the guiding port 2221 and the pushing member 241, can be set according to the actual situation and will not be elaborated in detail here.

[0057] It should be further noted that positioning seats are provided on the bottom inner walls of both the dye solution box 111 and the rinsing box 112, and positioning blocks are provided at the bottom of the staining bracket 2. After the staining bracket 2 is placed in the dye solution box 111 or the rinsing box 112, the positioning blocks can be inserted into the positioning seats to realize the positioning of the staining bracket 2.

[0058] Furthermore, referring to the attached drawings of the specification Figure 2 , the bracket driving mechanism 4 includes a first linear driving assembly 41, a second linear driving assembly 42 and a clamping assembly 43. The clamping assembly 43 is used for clamping the staining bracket 2. The second linear driving assembly 42 is installed at the output end of the first linear driving assembly 41, and the clamping assembly 43 is installed at the output end of the second linear driving assembly 42. The second linear driving assembly 42 is used for driving the staining bracket 2 to move linearly in the vertical direction, and the first linear driving assembly 41 is used for driving the staining bracket 2 to move linearly in the horizontal direction.

[0059] It should be noted that both the linear drive assembly 41 and the linear drive assembly 42 are linear motors. The clamping assembly 43 is installed at the output end of the linear drive assembly 42. After the dyeing bracket 2 is clamped by the clamping assembly 43, the linear drive assembly 41 and the linear drive assembly 42 can drive the dyeing bracket 2 to move.

[0060] Further, referring to the attached drawings of the specification Figure 15 , the clamping assembly 43 includes a housing 431. The housing 431 is fixedly installed at the output end of the linear drive assembly 42. A power component 432 is installed inside the housing 431. A gear 433 is installed at the output end of the power component 432. Two racks 434 are slidably arranged inside the housing 431. The closer sides of the two racks 434 are both engaged with the gear 433. Clamping seats 435 are fixedly arranged on both racks 434. Positioning shafts 436 are installed on both clamping seats 435. A top frame 21 is installed on the dyeing bracket 2. A positioning hole 211 is formed on the top frame 21. The positioning shaft 436 is adapted to the positioning hole 211.

[0061] It should be noted that the power component 432 is a motor. The motor drives the gear 433 to rotate, and drives the two clamping seats 435 to move closer to clamp the top frame 21 through the two racks 434. At the same time, the positioning shaft 436 is inserted into the positioning hole 211 to realize the clamping and fixing of the dyeing bracket 2.

[0062] Further, referring to the attached drawings of the specification Figure 16 , a moving flushing mechanism 5 is further arranged inside the machine shell 1. The moving flushing mechanism 5 includes a linear drive assembly 51 and a linear drive assembly 52. The linear drive assembly 52 is installed at the output end of the linear drive assembly 51. A flushing assembly 53 is installed at the output end of the linear drive assembly 52. The linear drive assembly 51 is used to drive the flushing assembly 53 to move linearly left and right horizontally. The linear drive assembly 52 is used to drive the flushing assembly 53 to move linearly back and forth horizontally.

[0063] It should be noted that both the linear drive assembly 51 and the linear drive assembly 52 are linear motors. The linear drive assembly 51 and the linear drive assembly 52 drive the flushing assembly 53 to move linearly inside the machine shell 1 to adjust the position of the flushing assembly 53 and realize its flushing work.

[0064] Further, referring to the attached drawings of the specification Figure 16 , the flushing assembly 53 includes a water pump 531. The water pump 531 is installed at the output end of the linear drive assembly 52. A flushing pipe 532 is installed at the water outlet end of the water pump 531. The output end of the flushing pipe 532 points to the section 31.

[0065] It should be noted that the water inlet end of the water pump 531 is connected to a water pipe, and the water inlet end of the water pipe can be connected to a water tank filled with distilled water. During flushing, the distilled water is pumped by the water pump 531 and the section 31 is flushed through the flushing pipe 532. While flushing, the flushing assembly 53 is driven to move by the linear drive assembly three 51 and the linear drive assembly four 52 of the linear motor, so as to uniformly flush the section 31 on the stained bracket 2 after unfolding.

[0066] The above embodiments only represent several implementation manners of the present invention, and the description thereof is relatively specific and detailed, but it should not be construed as a limitation to the scope of the patent of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several deformations and improvements can still be made, and these all belong to the protection scope of the present invention.

Claims

1. A staining analysis device for pathological diagnosis, characterized in that: include: A housing, a dyeing bracket, a sliding drive mechanism and a flushing assembly, wherein the housing is provided with a plurality of dyeing pools, the dyeing pools include a dye liquid box and a flushing box, and the housing is also provided with a bracket drive mechanism for driving the dyeing bracket to move; The staining bracket is provided with multiple groups of supporting components, and the supporting components include a fixed frame and two sliding frames, the fixed frame is fixedly arranged on the staining bracket, the sliding frame is slidably arranged on the staining bracket, and the fixed frame and the sliding frame are both hingedly provided with a placement frame for placing a slide glass; A plurality of pushers and toggles are slidably arranged in the dyeing bracket, and the sliding drive mechanism is used to drive the pushers and toggles to slide, so that the plurality of pushers push two adjacent sliding racks to slide out of the dyeing brackets in opposite directions, and the plurality of toggles toggles the plurality of placement racks to swing angles; A slide seat is slidably arranged in the dyeing bracket, a plurality of pushers and toggles are fixedly arranged on the slide seat, a plurality of slide frames are provided with guide openings at the bottom, the guide openings are inclined, the pushers are movably connected in the guide openings, and the guide openings at the bottoms of two adjacent slide frames are inclined in opposite directions; The sliding drive mechanism is a sliding drive component 1, and the sliding drive component 1 includes a stop block, which is fixedly arranged on the bottom inner wall of the washing box, and the top of the stop block is inclined. The bottom of the dyeing bracket is provided with an opening, and the bottom of the slide seat is provided with an abutment groove, the top inner wall of the abutment groove is inclined, and the top of the stop block and the top inner wall of the abutment groove have the same inclination angle, and an elastic member 1 is fixedly arranged on one side of the slide seat, and the end of the elastic member 1 away from the slide seat is fixedly arranged on the dyeing bracket.

2. A staining analysis device for pathological diagnosis according to claim 1, characterized in that: A rubber pad is fixedly arranged on the placement rack, and the rubber pad is used to fix the slide on the placement rack. Side holes are opened on the sides of the plurality of placement racks, and the toggle member is movably arranged in the side holes.

3. A staining analysis device for pathological diagnosis according to claim 2, characterized in that: A slide rod 1 is fixedly arranged on the other side of the slide seat, and the slide rod 1 is slidably arranged in the dyeing bracket, and a limit block 1 is fixedly arranged on the slide rod 1, and the limit block 1 is movably abutted against the dyeing bracket.

4. A staining analysis device for pathological diagnosis according to claim 3, characterized in that: The sliding drive mechanism is a sliding drive component 2, and the sliding drive component 2 includes a driving member, and the driving member is fixedly installed on the dye liquid box. The output end of the driving member extends into the dye liquid box and is fixedly provided with a push rod. Two elastic members and two slide rods are fixedly provided on both sides of the slide seat respectively. The two slide rods are slidably set in the dyeing bracket. Two limit blocks are fixedly provided on the two slide rods. The two limit blocks are movably abutted against the dyeing bracket, and a bottom groove is opened at the bottom of the two slide rods. The push rod is located in the bottom groove, and the push rod is movably abutted against the inner wall of the bottom groove.

5. A staining analysis device for pathological diagnosis according to claim 3 or 4, characterized in that: The bracket driving mechanism includes a linear drive component 1, a linear drive component 2 and a clamping component, the clamping component is used to clamp the dyeing bracket, the linear drive component 2 is installed at the output end of the linear drive component 1, and the clamping component is installed at the output end of the linear drive component 2. The linear drive component 2 is used to drive the dyeing bracket to move vertically linearly, and the linear drive component 1 is used to drive the dyeing bracket to move horizontally linearly.

6. A staining analysis device for pathological diagnosis according to claim 5, characterized in that: The clamping assembly includes a shell, which is fixedly installed on the output end of the linear drive assembly 2. A power component is installed in the shell, and a gear is installed on the output end of the power component. Two racks are slidably arranged in the shell, and the sides of the two racks that are close to each other are meshed with the gears. Clamp seats are fixedly arranged on the two racks, and positioning shafts are installed on the two clamp seats. A top frame is installed on the dyeing bracket, and a positioning hole is opened on the top frame. The positioning shaft is adapted to the positioning hole.

7. A staining analysis device for pathological diagnosis according to claim 6, characterized in that: A mobile flushing mechanism is also provided in the casing, and the mobile flushing mechanism includes a linear drive component three and a linear drive component four. The linear drive component four is installed at the output end of the linear drive component three, and the flushing component is installed at the output end of the linear drive component four. The linear drive component three is used to drive the flushing component to move horizontally and linearly to the left and right, and the linear drive component four is used to drive the flushing component to move horizontally and linearly to the front and back.

8. A staining analysis device for pathological diagnosis according to claim 7, characterized in that: The flushing component includes a water pump, which is installed at the output end of the linear drive component four. A flushing pipe is installed at the water outlet end of the water pump, and the output end of the flushing pipe points to the slice.

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