Stamp type drug delivery device capable of achieving high-capacity drug delivery

Abstract

The present invention is characterized by comprising: a needle part having a preset area and having a plurality of microneedles for insertion into the skin of a user; the elastic recovery part is in elastic contact with the needle part; the needle box provides a space for accommodating the needle part and the elastic recovery part, and a plurality of opening parts are formed in the bottom of the needle box; and a main body which is coupled to the needle cartridge and which applies pressure to the elastic recovery part by a force transmitted by a user.

Description

Technical Field

[0001] The present invention relates to a stamp-type drug delivery device capable of achieving high-capacity drug delivery, and more specifically, capable of simply and effectively delivering a high-capacity active ingredient or drug to the user's skin while also improving the skin absorption rate. Background Art

[0002] Generally, there are methods of delivering active ingredients or drugs into the body such as taking the drug orally, injecting the drug by injection, and absorbing the drug through the skin.

[0003] Among these methods, oral administration, i.e. taking drugs, may cause adverse reactions of the central nervous system such as headache, drowsiness, dizziness, and nervousness, as well as serious gastrointestinal-related adverse reactions such as nausea, indigestion, diarrhea, peptic ulcer, gastrointestinal bleeding, and perforation, and is therefore limited to short-term treatment.

[0004] In addition, the method of injecting drugs is to insert a needle into the skin and inject the drug directly into the body. Although it is absorbed quickly, it has the trouble that it can only be injected by professionals (self-injection is difficult), and usually a needle with a diameter of several millimeters is used. Therefore, the pain during injection leads to poor patient compliance.

[0005] In order to eliminate the side effects and disadvantages, a drug delivery system based on transdermal injection is being actively developed.

[0006] Generally, drugs absorbed through the skin are formulated in the form of liquids, creams, gels, etc. However, liquids, creams, and gels are difficult to adjust in volume due to their formulation characteristics, and there are problems with viscosity or coating contamination. In addition, most drugs have the problem of only a small amount being absorbed and most evaporating.

[0007] Therefore, a method of attaching a patch containing an active ingredient or a drug to the skin to deliver the drug subcutaneously is being used.

[0008] The use of patches can prevent side effects caused by taking drugs, such as gastrointestinal disorders and food influences, because the drugs are absorbed through the skin. It can also eliminate the pain and inconvenience of injections. Its convenience has led to a gradual increase in its usage in recent years.

[0009] However, the method of using a patch has the problem of low absorption rate of drugs absorbed through the skin. That is, the biggest disadvantage of the patch is the low absorption rate of drugs, so the function of the skin permeation barrier must be reduced. Generally speaking, the absorption rate of drugs absorbed through the patch is about 20%. So far, the known methods for improving the absorption rate include chemical methods such as using skin absorption accelerators and using prodrugs, and physical methods such as ion permeation therapy and electrophoresis.

[0010] However, even with these known methods, there are still limitations in increasing the absorption rate to a satisfactory level, and therefore, in order to increase the efficacy of the drug, it is inevitable to use an excessive amount of the drug in consideration of the absorption rate.

[0011] In particular, the type of skin absorption enhancer is determined by the design form of the preparation to be used or the physicochemical properties of the constituent components. In order to show the effect, a concentration above a certain level is required. The disadvantage of adding a skin absorption enhancer is that it is difficult to prevent crystallization over time, and the adhesive properties such as adhesion and cohesion change, making it unsuitable for use.

[0012] In addition, regarding the technology that utilizes electricity, since the patch must have a battery, electrodes, circuits and other components, the product structure becomes complicated, resulting in an increase in size, which is not only expensive, but also will generate a large amount of waste after use.

[0013] Therefore, in order to improve the skin absorption rate of active ingredients or drugs, molten polymer microneedles that carry active ingredients or drugs have been developed. However, the drug carrying capacity is small, and the skin penetration efficiency of the microneedles is reduced due to the strength limitations of the polymer. When attached to the skin, if the microneedles are attached to an inclined surface instead of a vertical direction, they will break. Therefore, there is a disadvantage that it is difficult to commercialize at present.

[0014] In order to solve the above problems, a method has been proposed in which a plurality of microneedles are formed and arranged on a thin bioabsorbable metal plate having ingredients beneficial to the human body and then attached to the skin.

[0015] However, as a condition for maximizing the delivery effect of active ingredients or drugs, it is difficult to form and arrange the microneedles on a limited plane area of ​​a metal plate.

[0016] In addition, there is a problem that the metal plate attached to the skin is easy to fall off the skin as the user moves. Therefore, the use of adhesive patches to prevent the metal plate from separating from the skin has been studied, but the adhesive patch and the metal plate need to be closely attached to the skin, which may cause users to reject it.

[0017] In addition, since the microneedles are formed on a very thin metal plate, there is a problem that they are easily broken or bent when inserted into the skin.

[0018] Therefore, the applicant proposes the present invention to solve the above-mentioned problems. The related prior art document is US Patent Publication No. 2007-0293815 “Microprojection array application with sculptured microprojections for high drug loading”. Summary of the invention

[0019] Technical issues to be solved

[0020] The present invention is used to solve the above-mentioned problems, and its purpose is to provide a stamp-type drug delivery device, which provides a structure for preventing multiple microneedles formed on a metal plate from breaking or deforming when they are inserted into the skin, and after the microneedles are inserted, additional pressure is applied to allow the active ingredients or drugs to be delivered to the skin through the microneedles.

[0021] In addition, the present invention aims to provide a stamp-type drug delivery device that can effectively deliver active ingredients or drugs to the subcutaneous tissue of a user without attaching a metal plate forming microneedles to the user's skin for a certain period of time, and in particular, can deliver a high capacity of active ingredients or drugs.

[0022] In addition, the present invention aims to provide a stamp-type drug delivery device, which arranges and forms microneedles with the highest possible density within a limited plane area of ​​a metal plate, thereby effectively delivering active ingredients or drugs.

[0023] Means of solving the problem

[0024] The present invention includes: a needle portion having a preset area and having a plurality of microneedles for inserting into the user's skin; an elastic recovery portion elastically contacting the needle portion; a needle box providing a space for accommodating the needle portion and the elastic recovery portion, with a plurality of openings formed at the bottom; and a main body combined with the needle box to apply pressure to the elastic recovery portion through the force transmitted by the user.

[0025] Furthermore, the needle portion may include: a first needle plate; a first protruding piece formed by cutting a portion of the area of ​​the first needle plate and protruding toward the opening of the needle box; and a plurality of microneedles disposed at the front end of the first protruding piece.

[0026] Furthermore, when the plurality of microneedles provided on the first protruding piece are inserted into the skin of a user, the first protruding piece and the microneedles formed on the first protruding piece are supported by contact with one side surface of the opening portion that defines the needle magazine.

[0027] Furthermore, the elastic restoring portion may include: a first restoring means which is laminated on the first needle plate and is pressed by the body; and a second restoring means which is disposed under the first needle plate and elastically supports the bottom of the first needle plate.

[0028] Furthermore, the first restoration means may include: a first restoration plate, forming an opening portion corresponding to the cutting opening on the first needle plate; and a plurality of first elastic components, formed by cutting a portion of the area of ​​the first restoration plate, bending upward at a preset angle and elastically contacting the bottom of the main body.

[0029] Furthermore, the second recovery means may include: a second recovery plate, located on the bottom surface of the needle box, forming an opening corresponding to the cutting opening on the first needle plate; and a plurality of second elastic components, formed by cutting a portion of the area of ​​the second recovery plate, bending upward at a preset angle and elastically contacting the bottom of the first needle plate.

[0030] Furthermore, the elastic force or rigidity of the second elastic member is smaller than that of the first elastic member, or the second elastic member is provided on the second restoring plate in a number smaller than that of the first elastic member.

[0031] Furthermore, the main body may include: a flow storage space for storing active ingredients or drugs; a guide flow path that can be connected to the flow storage space so that the active ingredients or drugs stored in the flow storage space flow; and a discharge component that guides the active ingredients or drugs flowing along the guide flow path to the opening of the needle box.

[0032] Furthermore, the present invention may further include: a connection part, one side of which is coupled to the upper end of the main body, and the other side of which is coupled to a storage part for storing active ingredients or drugs.

[0033] Furthermore, the needle portion includes: a second needle plate stacked on the first needle plate; a second protrusion piece formed by cutting a portion of the area of ​​the second needle plate and protruding toward the opening of the needle box; and a plurality of microneedles arranged at the front end of the second protrusion piece, wherein the second protrusion piece and the first protrusion piece are separated from each other by a preset interval.

[0034] Furthermore, when the plurality of microneedles provided on the second protruding piece are inserted into the skin of the user, the second protruding piece and the microneedles formed on the second protruding piece are supported by contact with the other side surface of the opening portion that partitions the needle magazine.

[0035] Furthermore, when the second needle plate is stacked on top of the first needle plate, the second protrusion piece passes through the cut formed in the first needle plate and is separated from the first protrusion piece at a preset interval. When the first needle plate is stacked on top of the second needle plate, the first protrusion piece passes through the cut formed in the second needle plate and is separated from the second protrusion piece at a preset interval.

[0036] Furthermore, slits capable of carrying and flowing active ingredients or drugs are formed on the microneedles of the needle portion.

[0037] Effects of the Invention

[0038] According to one embodiment of the present invention, in a stamp-type drug delivery device that can achieve high-capacity drug delivery, when a plurality of microneedles formed on a thin metal plate are inserted into the skin, the first protrusion piece or the second protrusion piece supporting the microneedles is supported by the inner wall surface of the opening portion that divides the needle box, or is supported by the discharge component of the main body that descends to discharge the active ingredient or drug, thereby preventing the microneedles from breaking or deforming.

[0039] Furthermore, according to an embodiment of the present invention, a stamp-type drug delivery device capable of achieving high-capacity drug delivery provides a structure for preventing multiple microneedles inserted into the skin from breaking or deforming due to external forces. Multiple microneedles can be made using thin metal plates, thereby improving manufacturing convenience and reducing manufacturing costs.

[0040] Furthermore, according to an embodiment of the present invention, a stamp-type drug delivery device that can achieve high-capacity drug delivery provides a structure for preferentially inserting microneedles arranged at a high density in a limited area into the skin, and can easily deliver active ingredients or drugs to the subcutaneous tissue through the microneedles, while stimulating the skin to provide beneficial effects.

[0041] Furthermore, according to a stamp-type drug delivery device that can achieve high-capacity drug delivery in one embodiment of the present invention, the microneedles are preferentially inserted into the user's skin through the user's first force, and the high-capacity active ingredients or drugs are delivered to the skin site where the microneedles are inserted through the user's second force, thereby improving the skin absorption rate of the active ingredients or drugs.

[0042] Furthermore, according to an embodiment of the present invention, a stamp-type drug delivery device that can achieve high-capacity drug delivery can provide not only skin stimulation and drug delivery effects, but also subcutaneous swelling effects and the function of a drug delivery enhancer, because the microneedles inserted into the skin contain bioabsorbable metal components that provide beneficial effects to the skin.

[0043] Furthermore, the stamp-type drug delivery device that can achieve high-capacity drug delivery according to one embodiment of the present invention also provides a structure that allows the microneedles inserted into the skin to be easily replaced according to the user, thereby preventing infection and allowing semi-permanent use. BRIEF DESCRIPTION OF THE DRAWINGS

[0044] Figure 1 It is a three-dimensional diagram of a stamp-type drug delivery device according to an embodiment of the present invention.

[0045] Figure 2 It is an isolated stereoscopic view of a stamp-type drug delivery device according to an embodiment of the present invention.

[0046] Figure 3 is a cross-sectional view of a stamp-type drug delivery device according to an embodiment of the present invention.

[0047] Figure 4 This is a perspective view of the structure of a needle portion according to an embodiment of the present invention as viewed from below.

[0048] Figure 5 This is a perspective view showing a state where a first needle plate and a second needle plate of a needle portion are stacked on each other as viewed from below.

[0049] Figure 6 It is a perspective view showing the structure of the elastic restoring portion according to one embodiment of the present invention.

[0050] Figure 7 It is shown Figure 6 A perspective view of a state in which the first restoring means is provided on the upper side of the second needle plate and the second restoring means is provided on the lower side of the first needle plate.

[0051] Figure 8 Observed from the side Figure 7 Side view of the elastic recovery portion and the needle portion.

[0052] Fig. 9 It is a perspective view of a main body of an embodiment of the present invention.

[0053] Fig.10 The subject is placed on the side when viewed from the side Figure 8 A side view of a state of the first elastic component.

[0054] Fig.11 This is a perspective view showing a state where a needle portion and an elastic restoring portion are accommodated in an inner space of a needle magazine according to an embodiment of the present invention.

[0055] Fig.12 is to show that the subject is placed Fig.11 A three-dimensional view of the upper portion of the elastic recovery portion.

[0056] Fig.13 Observed from below Fig.12 A three-dimensional image of a needle magazine.

[0057] Fig.14 This is an enlarged view of a microneedle according to an embodiment of the present invention.

[0058] Fig.15 It is a stereoscopic view of a stamp-type drug delivery device according to another embodiment of the present invention. DETAILED DESCRIPTION

[0059] Advantages and features of the present invention and methods of achieving the same will become clear through multiple embodiments described with reference to the accompanying drawings and in detail.

[0060] However, the present invention is not limited to the multiple embodiments disclosed below, but will be implemented in different various forms. These embodiments are only for the purpose of complete disclosure of the present invention and for fully informing the scope of the present invention to ordinary technicians in the technical field to which the present invention belongs. The present invention is only defined by the scope of the claims.

[0061] Refer to the following Figures 1 to 15 A stamp-type drug delivery device capable of delivering high-capacity drugs according to an embodiment of the present invention is described in detail. In describing the present invention, in order not to confuse the gist of the invention, the detailed description of related well-known functions or structures is omitted.

[0062] like Figures 1 to 3 As shown, a stamp-type drug delivery device 100 according to an embodiment of the present invention comprises: a needle portion 110 having a preset area and having a plurality of microneedles 111d, 113d (see Figure 4 ); an elastic recovery portion 130, which is in elastic contact with the needle portion 110; a needle box 150, which provides a space for accommodating the needle portion 110 and the elastic recovery portion 130, and has a bottom with a plurality of slit-shaped openings 151 formed therein; and a main body 170, which is detachably combined with the needle box 150, descends by a force transmitted by a user, applies pressure to the elastic recovery portion 130, and provides a space through which an active ingredient or drug to be delivered to the user's skin can pass.

[0063] First, the needle portion 110 is as follows Figure 2 and Figure 4 and Figure 5 As shown, a plurality of needle plates 111a, 113a are included.

[0064] For reference, the drawings show an embodiment of the present invention in which the needle portion 110 includes a first needle plate 111 a and a second needle plate 113 a .

[0065] The first needle plate 111a is a component built into the inner space of the needle box 150. Figure 4 As shown, it includes a first protruding piece 111c and a microneedle 111d.

[0066] The first protruding piece 111c is formed by cutting a part of the area of ​​the first needle plate 111a, that is, by cutting a part of the area of ​​the first needle plate 111a and then folding it in one direction.

[0067] Therefore, the first needle plate 111 a is provided with a cutout 111 b in order to form the first protruding piece 111 c. The cutout 111 b has a position and size corresponding to the discharge port 151 formed in the needle box 150 .

[0068] In one embodiment of the present invention, the drawings show that four first protruding pieces 111c and four cutting openings 111b are formed on the first needle plate 111a. However, the present invention is not limited thereto, and the number of the first protruding pieces 111c and the cutting openings 111b can be adjusted in various ways within the area formed by the first needle plate 111a.

[0069] In addition, the first protruding piece 111c protrudes toward the opening 151 of the needle box 150 formed when the first needle plate 111a is set in the inner space of the needle box 150. The first protruding piece 111c is set in a vertical direction or an inclined direction and protrudes toward the opening 151. For reference, in one embodiment of the present invention, the first protruding piece 111c is shown in a vertical posture through the drawings.

[0070] A plurality of microneedles 111d are formed at the front end of the first protruding piece 111c. The microneedles 111d are components for directly inserting into the user's skin, and are formed in plurality along the length direction of the first protruding piece 111c at predetermined intervals.

[0071] When the plurality of microneedles 111d formed on the first protruding piece 111c are inserted into the user's skin, the first protruding piece 111c and the microneedles 111d formed on the first protruding piece 111c are in contact with one side surface of the opening 151 that divides the needle box 150 and are supported.

[0072] In other words, during the process of inserting the plurality of microneedles 111d formed on the first protruding piece 111c into the skin, when the first protruding piece 111c or the plurality of microneedles 111d are about to break or bend, they come into contact with a side surface of the opening 151 dividing the needle box 150 and are supported.

[0073] Therefore, the plurality of microneedles 111 d of the first needle plate 111 a inserted into the skin are supported by one side surface of the opening 151 by the first protruding piece 111 c and can be easily inserted into the skin without being broken or deformed by external force.

[0074] The second needle plate 113a is also a component built into the inner space of the needle box 150. Figure 4 As shown, it includes a second protruding piece 113c and a microneedle 113d.

[0075] The second needle plate 113a is a member stacked in contact with the upper or lower surface of the first needle plate 111a. In one embodiment of the present invention, the second needle plate 113a is described as being stacked on the first needle plate 111a, and the drawings also show that the second needle plate 113a is set on the first needle plate 111a.

[0076] The second protruding piece 113c is formed by cutting a part of the area of ​​the second needle plate 113a, that is, by cutting a part of the area of ​​the second needle plate 113a and then folding it in one direction.

[0077] Therefore, in order to form the second protruding piece 113c, a cutout 113b is formed on the second needle plate 113a. The cutout 113b formed on the second needle plate 113a has a position and size corresponding to the cutout 111b formed on the first needle plate 111a.

[0078] In one embodiment of the present invention, the second needle plate 113a is shown to have four second protruding pieces 113c and four cutting openings 113b formed thereon, but the present invention is not limited thereto, and the number of the second needle plate 113a may correspond to the number of the first protruding pieces 111c and the cutting openings 111c on the first needle plate 111a.

[0079] The second protruding piece 113c is as follows Figure 4 and Figure 5 As shown, when the second needle plate 113a is stacked on the first needle plate 111a, the second needle plate 113a is separated from the first protruding piece 111c by a predetermined interval through the cutout 111b formed in the first needle plate 111a.

[0080] On the contrary, although not shown in the drawings, when the first needle plate 111a is stacked on the second needle plate 113a, the first protruding piece 111c of the first needle plate 111a passes through the cutout 113b on the second needle plate 113a and is separated from the second protruding piece 113c by a predetermined interval.

[0081] In addition, the second protruding piece 113c also protrudes toward the opening 151 formed in the needle box 150. The second protruding piece 113c is also arranged in a vertical direction or an inclined direction and protrudes toward the opening 151. For reference, in one embodiment of the present invention, the second protruding piece 113c is also shown in a vertical direction through the accompanying drawings.

[0082] A plurality of microneedles 113d of the second needle plate 113a are formed at the front end of the second protruding piece 113c. The microneedles 111d are components for directly inserting into the user's skin, and are formed in plurality along the length direction of the second protruding piece 113c at predetermined intervals.

[0083] When the plurality of microneedles 113d formed on the second protruding piece 113c are inserted into the user's skin, the microneedles 113d formed on the second protruding piece 113c and the second protruding piece 113c are in contact with the other side of the opening 151 formed in the needle box 150 and are supported.

[0084] In other words, during the process of inserting the plurality of microneedles 113d formed on the second protruding piece 113c into the skin, when the second protruding piece 113c or the plurality of microneedles 113d are about to break or bend, they are supported by contacting the other side of the opening 151 dividing the needle box 150.

[0085] Therefore, the plurality of microneedles 113d of the second needle plate 113a inserted into the skin are supported by the other side surface of the opening 151 by the second protruding piece 113c and can be easily inserted into the skin without being broken or deformed by external force.

[0086] The second needle plate 113a constructed as described above plays a role in increasing the density of the microneedles 111d and 113d within a limited plane space.

[0087] That is, within the limited planar space forming the needle box 150, the density and number of microneedles 111d and 113d are increased, and the insertion area of ​​the microneedles in contact with the user's skin is expanded, which plays a role in further improving the subcutaneous delivery effect of the active ingredient or drug.

[0088] In one embodiment of the present invention, the two first needle plates 111a and the second needle plates 113a are stacked on each other and arranged in the inner space of the needle box 150, but the present invention is not limited thereto. For example, one needle plate may be used alone, or two or more needle plates may be stacked to increase the density of microneedles.

[0089] Furthermore, the first needle plate 111a and the second needle plate 113a may be made of a metal containing at least one of magnesium, calcium, zinc, and iron, which are applied as bioabsorbable metals. Similarly, the protruding pieces 111c, 113c and the microneedles 111d, 113d provided on the first needle plate 111a and the second needle plate 113a are also made of a metal containing at least one of magnesium, calcium, zinc, and iron, which are applied as bioabsorbable metals.

[0090] For reference, in order to apply bioresorbable metals to plastic surgery implants, magnesium-based alloys have been produced and commercialized at home and abroad. In order to ensure safe fracture fixation, the focus of bioresorbable metals suitable for plastic surgery implants is to minimize the rate of decomposition in the body or improve corrosion resistance.

[0091] However, the bioabsorbable metal forming the first needle plate 111a, the second needle plate 113a, the protruding pieces 111c, 113c and the microneedles 111d, 113d of one embodiment of the present invention is different from the bioabsorbable metal suitable for plastic surgery, and a mechanism can be adopted to accelerate the decomposition rate in the body and release drugs subcutaneously while supplying minerals.

[0092] For example, magnesium, calcium, and zinc applied as bioabsorbable metals have a mechanism of reacting with water in the body to release hydrogen and decompose. Therefore, when the microneedles 111d and 113d provided in the first needle holder 111a and the second needle holder 113a, respectively, are inserted into the skin, ions and decomposition products are released from the subcutaneous tissue, and hydrogen, one of the byproducts, provides a swelling effect in the subcutaneous tissue, thereby having an effect of improving wrinkles.

[0093] At the same time, the byproducts ZnO and MgCl generated by inserting magnesium and zinc, which are components of bioabsorbable metals, into the body stay under the skin and can act as drug delivery enhancers that increase the absorption of active ingredients or drugs under the skin. Therefore, the first needle plate 111a and the second needle plate 113a formed of bioabsorbable metal have the function of effectively delivering the active ingredients or drugs carried by themselves or delivered from the outside to the subcutaneous tissue.

[0094] The elastic recovery portion 130 is as follows Figure 3 and Fig.11 As shown, it has a structure that is arranged in the inner space formed by the needle box 150 together with the needle part 110, and is compressed by the pressure transmitted by the main body 170.

[0095] To further explain, the elastic restoring part 130 has a structure that is compressed or restored to its original state based on the force transmitted by the user. For example, when the user transmits force, the force can be transmitted to the needle part 110. Then, the microneedles 111d and 113d provided in the needle part 110 are exposed to the outside through the opening 151 of the needle box 150. On the contrary, when the user releases the force, the restoring force is provided to restore the microneedles 111d and 113d inserted into the user's skin through the opening 151 of the needle box 150 to their original state.

[0096] The elastic restoring part 130 having the above functions is as follows Figures 6 to 8 As shown, a first restoring means 131 and a second restoring means 133 may be included.

[0097] The first restoring means 131 is a member provided on the upper part of the needle part 110 , and in one embodiment of the present invention, is laminated on the upper part of the second needle plate 113 a and receives pressure from the bottom of the main body 170 .

[0098] The second restoring means 133 is a component provided at the lower portion of the needle portion 110 , and in one embodiment of the present invention, is placed on the bottom surface of the needle box 150 while elastically supporting the bottom of the first needle plate 111 a .

[0099] First, the first restoration means 131 may include: a first restoration plate 131a, forming an opening portion 131c having a position and size corresponding to the cutting opening 111b on the first needle plate 111a; and a plurality of first elastic components 131b, which are formed by cutting a portion of the area of ​​the first restoration plate 131a, and are bent upward at a preset angle to elastically contact the bottom of the main body 170.

[0100] The second recovery means 133 may include: a second recovery plate 133a, located on the bottom surface of the needle box 150, forming an opening portion 133c corresponding to the cutting port 111b on the first needle plate 111a; and a plurality of second elastic components 133b, formed by cutting a portion of the area of ​​the second recovery plate 133a, bending upward at a preset angle and elastically contacting the bottom of the first needle plate 111a.

[0101] The plane area of ​​the first restoring plate 131a and the second restoring plate 133a may be smaller than the plane area of ​​the first needle plate 111a or the second needle plate 113a.

[0102] Furthermore, the first restoring plate 131a and the second restoring plate 133a may be made of a metal material or a plastic material having elastic restoring force.

[0103] When the main body 170 moves vertically downward, the first elastic member 131b is folded to the same height as the first restoring plate 131a by the pressure from the bottom of the main body 170. On the contrary, when the force transmitted to the main body 170 is released, the first elastic member 131b protrudes upward from the first restoring plate 131a and returns to its original state.

[0104] The first elastic member 131b has a shape that protrudes upward from the first restoring plate 131a and then protrudes horizontally. This shape can be said to be a shape that is easily subjected to the bottom pressure of the main body 170. In addition, when the force transmitted to the main body 170 is released, it can be rotated on the first restoring plate 131a and easily restored to the original state.

[0105] When the main body 170 moves vertically downward, the second elastic member 133b is subjected to pressure from the bottom of the lowermost needle plate 111a, 113a among the plurality of needle plates 111a, 113a constituting the needle portion 110, and is folded to the same height as the second restoration plate 133a. For reference, in one embodiment of the present invention, the second elastic member 133b is shown in the accompanying drawings in contact with the bottom of the first needle plate 111a and when the main body 170 moves vertically downward, the first needle plate 111a is subjected to pressure. On the contrary, when the force transmitted to the main body 170 is released, it can protrude upward on the second restoration plate 133a and return to the original state.

[0106] The second elastic member 133b also has a shape that protrudes upward from the second restoring plate 133a in an oblique manner and then protrudes horizontally. This shape can be said to be a shape that is easily subjected to the bottom pressure of the first needle plate 111a or the second needle plate 113a, and when the force transmitted to the main body 170 is released, it can be rotated on the second restoring plate 133a and easily restored to the original state.

[0107] In addition, the elastic force or rigidity of the second elastic component 133b is smaller than the elastic force or rigidity of the first elastic component 131b, or the number of the second elastic components 133b is smaller than the number of the first elastic components 131b on the second restoring plate 133a.

[0108] Therefore, when the user transmits the first force to the body 170 to lower the body 170 , the second elastic member 133 b provided on the second restoring plate 133 a is compressed preferentially compared to the first elastic member 131 b provided on the first restoring plate 131 a .

[0109] Then, based on the first force of the user, the microneedles 111d and 113d of the needle unit 110 are exposed through the opening 151 of the needle box 150 and inserted into the skin of the user.

[0110] Next, when a second force greater than the first force is generated, the main body 170 will further drop, thereby compressing the first elastic member 131b of the first restoration plate 131a. Thus, the discharge member 175 of the main body 170 described later is close to the user's skin, and the active ingredient or medicine can be discharged quickly and in large volume to the user's skin.

[0111] As described above, by setting the elastic force, rigidity, number of the first elastic member 131b and the second elastic member 133b differently, the first restoring means 131 and the second restoring means 133 are compressed or restored with a time difference. Therefore, the user can adjust the applied pressure appropriately to sequentially realize the functions of the drug delivery device based on the double action. For example, the microneedles 111d and 113d can be preferentially inserted into the skin by a first operation of applying a first force, and a high-capacity active ingredient or drug can be delivered to the skin by a second operation of applying a second force.

[0112] The needle box 150 is as follows Figures 11 to 13 As shown, a preset space is formed to accommodate the aforementioned needle portion 110 and the elastic restoring portion 130 .

[0113] Furthermore, a plurality of openings 151 are formed at the bottom of the needle box 150 .

[0114] The opening 151 is formed in various shapes and sizes at the bottom of the needle box 150. In one embodiment of the present invention, the drawings show that four openings 151 are formed with a predetermined interval between them.

[0115] In addition, the shape, size and number of the opening 151 formed in the needle box 150 will serve as the basis for the shape, size and number of the cutting openings 111b, 113b forming the needle part 110 and the openings 131c, 133c constituting the elastic recovery part 130.

[0116] Furthermore, a portion of the first protruding piece 111 c in the longitudinal direction, a portion of the second protruding piece 113 c in the longitudinal direction, and the microneedles 111 d and 113 d are exposed to the outside through the opening 151 .

[0117] The main body 170 is as follows Fig.11 As shown, it can be removably coupled to the needle magazine 150.

[0118] The method of detachably combining the main body 170 and the needle box 150 can adopt a variety of well-known methods. For example, a ring portion is formed on the needle box 150, and a protrusion inserted into and hooked to the ring portion is formed on the main body 170, so as to detachably combine the main body 170 and the needle box 150.

[0119] For reference, the reason for detachably combining the main body 170 and the needle box 150 is to enable the user to easily replace the needle part 110 and the elastic restoration part 130 provided to the inner space of the needle box 150 .

[0120] The main body 170 is as follows Fig. 9 and Fig.10 As shown, it includes: a flow storage space 171 for storing active ingredients or drugs; a guide flow path 173 that can be connected to the flow storage space 171 to allow the active ingredients or drugs stored in the flow storage space 171 to flow; and a discharge component 175 that guides the active ingredients or drugs flowing along the guide flow path 173 to the opening 151 of the needle box 150.

[0121] The storage space 171 stores the fluid from the storage unit 200 (refer to Figure 2 and Figure) to discharge the active ingredients or drugs.

[0122] For reference, the main body 170 and the storage portion 200 are as shown in FIG. Figure 2 and Figure 3 As shown, the connecting portion 190 is connected to each other through the connecting portion 190. That is, the connecting portion 190 has a hollow shape, and one side thereof is detachably coupled to the open upper portion of the main body 170. And, the other side of the connecting portion 190 is detachably coupled to the storage portion 200.

[0123] The connection part 190 and the main body 170 or the storage part 200 can be detachably connected in various known ways, such as interference fit, screw connection, etc.

[0124] Furthermore, the storage part 200 provides a space for storing active ingredients or drugs and has a predetermined strength. The storage part 200 can be made into various types such as a container type and a capsule type.

[0125] Therefore, the active ingredient or drug discharged from the storage part 200 temporarily stays in the reservoir space 171 of the main body 170 via the connection part 190 .

[0126] The active ingredient or drug remaining in the flow storage space 171 may flow into the guide flow path 173 .

[0127] The guide flow paths 173 are provided in the main body 170 at positions and numbers corresponding to the positions and numbers of the openings 151 on the needle magazine 150 .

[0128] The guide flow path 173 may be formed in the body 170 in a gradually narrowed space to increase the flow rate of the active ingredient or medicine stored in the reservoir space 171. For example, the guide flow path 173 may be divided by a pair of inclined surfaces.

[0129] The discharge member 175 may be connected to the guide flow path 173, such as Fig.10 As shown, it has a shape protruding from the bottom surface of the main body 170.

[0130] The discharge member 175 may be sequentially inserted into the opening 131c formed in the first restoring plate 131a, the cutouts 111b and 113b formed in the needle 110, and the opening 133c formed in the second restoring plate 133a.

[0131] That is, when the main body 170 descends, the discharge member 175 sequentially passes through the opening 131c of the first restoration plate 131a, the cutouts 111b and 113b of the needle 110, and the opening 133c of the second restoration plate 133a, and is located at a position corresponding to the opening 151 formed in the needle box 150. In this state, the active ingredient or drug is rapidly delivered to the skin via the guide flow path 173.

[0132] Among them, the discharge component 175 passes through the space between the first protrusion piece 111c formed on the first needle plate 111a and the second protrusion piece 113c formed on the second needle plate 113a, thereby sweeping down the medicine applied to the first protrusion piece 111c and the second protrusion piece 113c and quickly transferring it to the user's skin.

[0133] In addition, since the discharge component 175 is disposed between the first protruding piece 111c and the second protruding piece 113c, it is capable of supporting the first protruding piece 111c and the second protruding piece 113c when the plurality of microneedles 111d formed on the first needle plate 111a and the plurality of microneedles 113d formed on the second needle plate 113a are inserted into the skin.

[0134] The discharge component 175 cooperates with one side of the opening portion 151 of the needle box 150 to prevent the first protrusion piece 111c and the microneedle 111d of the first needle plate 111a from breaking or deforming in other directions. At the same time, it cooperates with the other side of the opening portion 151 of the needle box 150 to prevent the second protrusion piece 113c and the microneedle 113d of the second needle plate 113a from breaking or deforming in one direction.

[0135] That is, the discharge member 175 prevents from forming a space where the first protruding piece 111 c and the second protruding piece 113 c may be broken or deformed.

[0136] Therefore, the discharge member 175 plays a role in further preventing the microneedles 111d and 113d having micro units from being accidentally broken or deformed during the process of being inserted into the skin.

[0137] According to a stamp-type drug delivery device of an embodiment of the present invention having the above-described structure, when a plurality of microneedles formed on a thin metal plate are inserted into the skin, the first protrusion piece or the second protrusion piece supporting the microneedles is supported by the inner wall surface of the opening portion that divides the needle box, or is supported by a discharge component of the main body that descends to discharge the active ingredient or drug, thereby preventing the microneedles from breaking or deforming.

[0138] In addition, since a structure is provided for preferentially inserting microneedles arranged at a high density within a limited area into the skin, effective ingredients or drugs can be easily delivered to the subcutaneous tissue through the microneedles, while stimulating the skin to provide beneficial effects.

[0139] Although specific embodiments of the present invention have been described, various modifications may be made without departing from the scope of the present invention.

[0140] For example, Fig.14 As shown, in order to improve the subcutaneous delivery effect of active ingredients or drugs, slits S may be formed on the microneedles 111d and 113d to carry the active ingredients or drugs and allow them to flow.

[0141] The slits S are formed in a direction parallel to the insertion direction of the microneedles 111d and 113d, and the drug as an active ingredient can be quickly and easily delivered to the skin.

[0142] The length or width and the formation position of the slit S correspond to the shape and size of the microneedles 111d and 113d, and can be set in various ways.

[0143] Furthermore, although the stamp-type drug delivery device 100 of one embodiment of the present invention is described as the active ingredient or drug stored in the storage part 200 being delivered to the skin via the connecting part 190, the main body 170, the needle part 110 and the needle box 150 in sequence, it is not limited thereto.

[0144] For example, Fig.15 As shown, the storage part 200 for storing active ingredients or drugs can be omitted. The main body 170 can be changed to a shape and volume capable of storing active ingredients or drugs, and the connecting part 190 can play the role of a cover covering the open upper part of the main body 170.

[0145] Furthermore, as described above, the stamp-type drug delivery device 100 according to an embodiment of the present invention uses metal containing components beneficial to the human body to make the needle part 110, and the microneedles 111d and 113d themselves can produce beneficial effects on the user.

[0146] Therefore, the user can use the stamp-type drug delivery device 100 of the present invention only for inserting the microneedles 111d and 113d into the skin. In this case, the storage part 200 for storing active ingredients or drugs can be omitted. In addition to transmitting the user's force to the needle part 110, the main body 170 also plays a role in preventing the first protruding piece 111c and the second protruding piece 113c and the microneedles 111d and 113d from breaking or deforming when the microneedles 111d and 113d are inserted into the skin.

[0147] Therefore, the scope of the present invention should not be limited to the described embodiments, but should be determined based on the scope of the following claims and their equivalents.

Claims

1. A stamp-type drug delivery device capable of achieving high-capacity drug delivery, characterized in that: include: a needle portion having a predetermined area and a plurality of microneedles for insertion into the skin of a user; an elastic restoring portion, in elastic contact with the needle portion; A needle box, providing a space for accommodating the needle part and the elastic restoring part, with a plurality of openings formed at the bottom; and The main body is combined with the needle box and applies pressure to the elastic restoring part through the force transmitted by the user.

2. The stamp-type drug delivery device capable of achieving high-capacity drug delivery according to claim 1, It is characterized in that It includes: a first needle plate; A first protruding piece is formed by cutting a part of the area of ​​the first needle plate and protrudes toward the opening of the needle box; A plurality of microneedles are arranged at the front end of the first protruding piece.

3. The stamp-type drug delivery device capable of achieving high-capacity drug delivery according to claim 2, characterized in that: When the plurality of microneedles provided on the first protruding piece are inserted into the skin of a user, the first protruding piece and the microneedles formed on the first protruding piece are supported by contact with one side surface of the opening portion that defines the needle magazine.

4. The stamp-type drug delivery device capable of achieving high-capacity drug delivery according to claim 2, characterized in that: The elastic restoring portion includes: a first restoring means, which is laminated on the upper part of the first needle plate and is pressed by the main body; and The second restoring means is arranged at the lower part of the first needle plate and elastically supports the bottom of the first needle plate.

5. The stamp-type drug delivery device capable of achieving high-capacity drug delivery according to claim 4, characterized in that: The first restoration means comprises: a first restoration plate, forming an opening corresponding to the cutout on the first needle plate; and A plurality of first elastic components are formed by cutting a portion of the area of ​​the first restoration plate, and are bent upward at a preset angle to elastically contact with the bottom of the main body.

6. The stamp-type drug delivery device capable of achieving high-capacity drug delivery according to claim 5, characterized in that: The second restoration means comprises: a second restoration plate, located on the bottom surface of the needle box, forming an opening corresponding to the cutting opening on the first needle plate; and A plurality of second elastic components are formed by cutting a portion of the area of ​​the second restoration plate, and are bent upward at a preset angle to elastically contact with the bottom of the first needle plate.

7. The stamp-type drug delivery device capable of achieving high-capacity drug delivery according to claim 6, characterized in that: The elastic force or rigidity of the second elastic member is smaller than that of the first elastic member, or the second elastic member is provided to the second restoring plate in a smaller number than the first elastic member.

8. The stamp-type drug delivery device capable of achieving high-capacity drug delivery according to claim 2, characterized in that: The main body includes: a fluid storage space for storing active ingredients or drugs; A guide flow path can be connected to the flow storage space to allow the effective ingredients or drugs stored in the flow storage space to flow; and The discharge member guides the active ingredient or drug flowing along the guide flow path to the opening of the needle cartridge.

9. The stamp-type drug delivery device capable of achieving high-capacity drug delivery according to claim 1, characterized in that: The invention also comprises a connecting part, one side of which is coupled to the upper end of the main body, and the other side of which is coupled to a storage part for storing active ingredients or drugs.

10. The stamp-type drug delivery device capable of achieving high-capacity drug delivery according to claim 2, characterized in that: The needle portion includes: a second needle plate stacked to the first needle plate; A second protruding piece is formed by cutting a part of the area of ​​the second needle plate and protrudes toward the opening of the needle box; and A plurality of microneedles are arranged at the front end of the second protruding piece, Wherein, the second protruding piece and the first protruding piece are spaced apart from each other at a preset interval.

11. The stamp-type drug delivery device capable of achieving high-capacity drug delivery according to claim 10, characterized in that: When the plurality of microneedles provided on the second protruding piece are inserted into the skin of a user, the second protruding piece and the microneedles formed on the second protruding piece are supported by contact with the other side surface of the opening that partitions the needle magazine.

12. The stamp-type drug delivery device capable of achieving high-capacity drug delivery according to claim 10, characterized in that: When the second needle plate is stacked on the first needle plate, the second protruding piece passes through the cutout formed in the first needle plate and is separated from the first protruding piece by a predetermined interval. When the first needle plate is stacked on the second needle plate, the first protruding piece passes through the cutout formed in the second needle plate and is spaced apart from the second protruding piece by a predetermined interval.

13. The stamp-type drug delivery device capable of achieving high-capacity drug delivery according to claim 10, characterized in that: The microneedles of the needle part have slits formed therein that can carry and flow active ingredients or drugs.

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