Food composition for improving qi depression and blood stasis constitution and preventing and treating breast nodule hyperplasia

Abstract

The invention belongs to the technical field of functional foods, and discloses a food composition for improving the constitution of qi depression and blood stasis and preventing and treating breast nodule hyperplasia. The food composition is prepared from the following raw material components in parts by weight: 20-40 parts of double-petal red roses, 20-30 parts of haws, 10-30 parts of dandelions, 10-30 parts of galactomannan, 15-30 parts of codonopsis pilosula, 15-20 parts of astragalus membranaceus, 15-20 parts of maca, 15-20 parts of rhizoma polygonati, 10-15 parts of fingered citron, 10-15 parts of kelp, 5-10 parts of folium cortex eucommiae, 5-8 parts of American ginseng and 0.1-1 part of mushroom powder. The food composition disclosed by the invention takes food therapy as a conditioning idea, and achieves the effects of dredging, activating, dispersing, benefiting, tonifying and conditioning at multiple targets, and the effects of soothing liver and regulating qi, promoting blood circulation to remove blood stasis, softening hardness to dissipate stagnation, replenishing qi to invigorate spleen, nourishing liver and kidney and conditioning intestinal tracts are combined, so that the constitution of qi depression and blood stasis is improved, and the effect of preventing and treating breast nodule hyperplasia is further achieved.

Description

Technical Field

[0001] The invention belongs to the technical field of functional foods, and in particular relates to a food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodule hyperplasia. Background Art

[0002] Breast hyperplasia is the most common breast disease in women, and its incidence ranks first among breast diseases. In recent years, the incidence of the disease has been increasing year by year, and the age of onset is getting younger and younger. According to surveys, about 70% to 80% of women have breast hyperplasia nodules to varying degrees, and they are more common in women aged 25 to 45.

[0003] At present, the cause of breast nodules has not been fully clarified. Studies have pointed out that the proliferation of breast nodules is related to changes in estrogen levels. The proportion and degree of anxiety and depression in patients with breast hyperplasia are higher than those in healthy people. Mental stress and bad psychological state are important risk factors for breast hyperplasia. The hyperplastic tissue cannot recover or recover incompletely, forming nodules or fibroids, accompanied by breast pain.

[0004] Commonly used western medicines in modern medicine, such as oral hormone drugs or surgical treatment, are mainly used to regulate endocrine. Although the short-term effect is better, the prognosis recurrence rate is high, and there are certain adverse reactions, which can lead to obesity, menstrual imbalance, amenorrhea, etc., and the side effects of the drugs are large. Traditional Chinese medicine treatment is mainly based on soothing the liver and relieving depression, dispersing knots and removing blood stasis. Commonly used clinical medicines include Xiaoyao Pills, Rupixiao Tablets and Xiaojin Capsules. Patent CN 110141651 A discloses a Chinese medicine for preventing and treating breast hyperplasia, which is prepared from raw materials Tianjiang Shell, Ebushicao, Oroxylum, Water Chestnut, Curcuma Longa, and Deer Horn Frost. The purpose of preventing and treating breast nodules is achieved by improving the patient's physique. Patent CN 116942778 A discloses a Chinese medicine composition for preventing and treating breast nodules, which comprises the following raw materials in weight ratio: 5-15 parts of bupleurum, 5-15 parts of immature bitter orange, 5-15 parts of white peony root, 5-15 parts of dried ginger, 4-14 parts of ginger pinellia, 15-25 parts of chicken gizzard lining, 15-25 parts of raw coix seed, 10-20 parts of salvia miltiorrhiza, 1-5 parts of notoginseng powder, 4-14 parts of turmeric, 5-15 parts of cinnamon twig, 5-15 parts of poria, 5-15 parts of atractylodes, and 5-15 parts of raw licorice. The Chinese medicine composition provided by the invention can be used to improve qi stagnation and blood stasis constitution, prevent and treat breast hyperplasia and breast nodules. Although the above-mentioned drugs have different degrees of efficacy, the improvement principle is relatively simple, the symptom improvement time is long, and the general cure rate is low. In addition, the above-mentioned drugs are mainly prepared by simple crushing and decoction of pure Chinese medicine components, and their efficacy and taste acceptance are poor.

[0005] The Collection of External Symptoms Medical Cases mentions that the treatment of breast diseases should start with "Qi". Therefore, it can be seen that the onset of breast nodules is also closely related to emotional disorders. According to traditional Chinese medicine, there are two main causes of breast nodules: one is internal emotional injury, due to anger and worry, the liver and spleen are injured, and the invisible Qi is stagnant and gelled. The second is the disorder of Chong and Ren, and the poor circulation of Qi and blood. It is necessary to soothe the liver and regulate Qi, regulate Qi and blood, regulate Qi and resolve phlegm, and resolve dysmenorrhea. Breast nodules belong to the category of "breast nodules", "breast lumps", "breast phlegm" and "breast rocks" in traditional Chinese medicine. The disease is located in the breast and is closely related to the spleen, stomach, liver and kidney.

[0006] As we all know, intestinal flora plays an important role in maintaining human health. Dysbiosis means changes in the composition and function of the intestine, which in turn causes intestinal barrier dysfunction. Imbalance in intestinal flora and function will cause various chronic diseases.

[0007] Therefore, it is very necessary to develop a healthy food that focuses on soothing the liver and regulating qi, promoting blood circulation and removing blood stasis, invigorating qi and strengthening the spleen, and nourishing the liver and kidneys, supplemented by balancing the intestinal flora, and adopts the concept of multi-level and multi-target holistic diet therapy to improve the physical condition of qi stagnation and blood stasis, and then prevent and treat breast nodule hyperplasia. Summary of the invention

[0008] In view of the shortcomings and deficiencies of the above prior art, the primary purpose of the present invention is to provide a food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodule hyperplasia. The food composition of the present invention takes diet therapy as the conditioning concept, and multiple targets achieve the effects of "soothing, activating, dispersing, benefiting, replenishing and regulating", which is embodied in the combination of soothing the liver and regulating qi, activating blood circulation and removing blood stasis, softening and dispersing nodules, benefiting qi and strengthening the spleen, nourishing the liver and kidneys and regulating the intestines, thereby improving qi stagnation and blood stasis constitution, and then achieving the effect of preventing and treating breast nodule hyperplasia.

[0009] Another object of the present invention is to provide a method for preparing the food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodular hyperplasia. The preparation method of the present invention can effectively improve the efficacy and taste acceptability.

[0010] The purpose of the present invention is achieved through the following technical solutions:

[0011] A food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodular hyperplasia is prepared from the following raw material components in parts by weight:

[0012] 20-40 parts of double red roses, 20-30 parts of hawthorn, 10-30 parts of dandelion, 10-30 parts of galactomannan, 15-30 parts of codonopsis, 15-20 parts of astragalus, 15-20 parts of maca, 15-20 parts of polygonatum, 10-15 parts of bergamot, 10-15 parts of kelp, 5-10 parts of eucommia leaves, 5-8 parts of American ginseng, and 0.1-1 part of mushroom powder. Preferably, the galactomannan is a short-chain, low-polymerization galactomannan with a molecular weight of 20-30 kDa obtained by using natural guar beans as raw materials, and degrading the high-molecular galactomannan polysaccharide (-2000 kDa) in guar beans through enzymatic hydrolysis, separation and purification, and drying processes.

[0013] The preparation method of the food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodular hyperplasia comprises the following preparation steps:

[0014] 1) washing double red roses, hawthorn and eucommia leaves respectively, removing the core of hawthorn, sterilizing, drying, crushing and sieving to obtain material A;

[0015] (2) washing and sterilizing dandelion, codonopsis, astragalus, maca, polygonatum, citron, kelp, American ginseng and mushroom powder, drying, crushing and sieving, and then puffing, adding water for ultrasonic immersion, and then decocting, reducing pressure and concentrating to a thick paste, and continuing to dry and crushing and sieving to obtain material B;

[0016] (3) Raw material A, raw material B and galactomannan are mixed to obtain the food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodule hyperplasia.

[0017] Furthermore, the drying in step (1) refers to drying at a temperature of 70-90° C. until the weight percentage of moisture in the material is 5%-7%, and the crushing and screening refers to passing through an 80-100 mesh sieve after crushing.

[0018] Furthermore, the drying, crushing and screening after cleaning and sterilization in step (2) refers to drying at a temperature of 70 to 90° C. until the material has a moisture content of 5% to 7% by weight, and then passing through a 180 to 200 mesh sieve after crushing.

[0019] Furthermore, the puffing treatment in step (2) refers to puffing treatment in a screw extruder, the puffing treatment temperature is 80-100° C., the screw speed is 150-200 r / min, and the time is 2-4 h.

[0020] Furthermore, the amount of water added in step (2) is 4 to 8 times the mass of the material; the ultrasonic power of the ultrasonic immersion treatment is 120 to 180 W, and the time is 2 to 3 hours.

[0021] Furthermore, the decoction time in step (2) is 1 to 4 hours; the further drying followed by crushing and screening refers to drying at a temperature of 70 to 90° C. and then crushing and passing through a sieve of 80 to 100 meshes.

[0022] Furthermore, the mixed preparation in step (3) is further added with auxiliary materials or carriers to be prepared into powders, tablets, pills, granules, capsules, oral liquids, etc.; the auxiliary materials (such as dietary fibers or prebiotics such as polydextrose, resistant dextrin and oligofructose) or carriers include at least one of diluents, adhesives, dispersants, lubricants, disintegrants, solvents, flavor regulators (such as fruit powder, sweeteners or acidity regulators, etc.).

[0023] The ingredients of the food composition of the present invention are mostly raw materials that are both medicinal and edible. Each raw material has a clear meridian in the human body's internal organs, and can target and dredge the meridians to achieve the effects of soothing the liver and regulating qi, promoting blood circulation and removing blood stasis, softening and dispersing nodules, invigorating qi and strengthening the spleen, and nourishing the liver and kidneys. In addition, in an environment of healthy and balanced intestinal flora, it supplements the nutrients such as vitamins needed by the human body, and the multi-level and multi-target combination has a synergistic effect with each other.

[0024] Double red roses are rich in vitamin C, tannins, carotene, isoquercetin, etc. They can promote blood circulation and remove blood stasis, warm the stomach and invigorate the spleen, relieve liver depression, harmonize the internal organs, soothe emotions and regulate endocrine. They are used to treat liver depression and qi stagnation, irregular menstruation, and premenstrual breast pain, and have a good preventive and therapeutic effect. Women with breast hyperplasia usually have qi stagnation and blood stagnation, and double red roses can dredge the meridians and qi and blood, and help dredge the breasts.

[0025] Hawthorn is a food and medicine substance. It enters the spleen, stomach, and liver meridians, and has the effects of strengthening the spleen and appetizing, digesting food and removing stagnation, promoting blood circulation and removing phlegm. It has a good effect on chest and spleen fullness, hernia, blood stasis, amenorrhea, etc. For people with blood stasis constitution, eating hawthorn can replenish blood and relieve depression.

[0026] Dandelion is a substance that can be used as both medicine and food. It contains many healthy nutrients such as dandelion alcohol, dandelion extract, choline, organic acids, etc. Since dandelion belongs to the liver meridian and stomach meridian, it has good effects of clearing heat and detoxifying, reducing swelling and dispersing nodules.

[0027] Galactomannan is made from natural guar beans. After a series of processes such as enzymatic hydrolysis, separation and purification, and drying, the high molecular weight galactomannan polysaccharide (~2000kDa) in guar beans is degraded into short-chain, low-polymerization galactomannan (20~30kDa), thereby effectively reducing the viscosity of the product, increasing fermentability, and promoting the utilization of probiotics in the intestine. In 2011, the European Food Safety Authority (EFSA) approved the relevant health claims of galactomannan (foreign trade name PHGG), including reducing potential pathogenic gastrointestinal microorganisms, regulating the production of short-chain fatty acids and regulating changes in gastrointestinal pH, regulating intestinal function and reducing gastrointestinal discomfort.

[0028] Codonopsis is a substance that is both a medicine and food. It is sweet and neutral in nature. It belongs to the lung meridian and spleen meridian. It is a Qi-tonifying drug with the effects of replenishing Qi and promoting body fluid, strengthening the body and eliminating evil. It can replenish the spleen and Qi, treat spleen and lung Qi deficiency syndrome, and mainly replenish the Qi of the spleen and lungs. It can treat physical weakness, fatigue, and poor appetite caused by insufficient Qi in the middle.

[0029] Astragalus is a substance with medicinal and edible properties. It is sweet and slightly warm in nature and enters the lung and spleen meridians. Its main functions are to strengthen the spleen and replenish the middle, raise yang and lift the sunken, and strengthen the body's defense and exterior. It is mainly used in the clinical treatment of spleen qi deficiency syndrome. Astragalus is an important medicine for replenishing the middle and replenishing qi.

[0030] Maca is a new food ingredient, which belongs to the heart, liver, and kidney meridians. It contains more iron, protein, amino acids, minerals, etc. It also includes zinc, taurine and other ingredients. It is beneficial to fight fatigue, increase muscle endurance, and resist sports fatigue. It has the functions of nourishing kidney yang, nourishing the heart and liver, and helping yang and promoting body fluid. It has anti-fatigue effect and can enhance the vitality of the human body.

[0031] Polygonatum sibiricum is sweet in taste, mild in nature, non-toxic, and belongs to the lung, spleen, and kidney meridians. Its effects and functions are to tonify the kidney and lungs, replenish qi and nourish blood, tonify the spleen and replenish qi, and nourish the kidney and replenish essence.

[0032] Buddha's hand tastes pungent, bitter, sour, and warm in nature. It is used for chest and flank pain, abdominal distension and fullness caused by liver depression and qi stagnation, liver and stomach disharmony, abdominal distension and pain, nausea and loss of appetite caused by spleen and stomach qi stagnation, long-term cough with a lot of sputum, and chest pain. It has the effects of regulating qi and resolving phlegm, removing dampness, stopping vomiting and reducing swelling, and soothing the liver and strengthening the spleen.

[0033] Kelp is salty in taste, cold in nature, and enters the liver and kidney meridians. It has a good effect of softening and dispersing nodules, helping to soften and dissipate hard lumps, and can promote the absorption of nodules, thereby playing a role in unblocking blood and qi and subsiding lumps. It also has the effect of promoting diuresis and reducing swelling, which can accelerate the metabolism of water in the body, help relieve uncomfortable symptoms such as difficulty urinating and defecation, and has a good conditioning effect on the body.

[0034] Eucommia leaves are slightly pungent and warm in nature. They belong to the liver and kidney meridians and have the effects of nourishing the liver and kidneys and strengthening the tendons and bones. At the same time, they can enhance gastrointestinal motility, treat constipation, and thus improve intestinal health.

[0035] American ginseng is sweet, warm, moist, and belongs to the heart meridian. It is a good blood tonic. It can also promote blood circulation and remove blood stasis, inhibit platelet aggregation, and reduce the incidence of thrombosis. It also contains rich volatile oils, which can moisten the intestines, remove intestinal toxins, and have a therapeutic effect on constipation caused by blood deficiency and intestinal dryness.

[0036] Mushroom powder is rich in dietary fiber and polysaccharides, which can help enhance gastrointestinal motility and promote defecation, helping to alleviate constipation problems. Studies have confirmed that VDR is related to intestinal flora. The lack of VDR (vitamin receptor) can lead to intestinal inflammation. Clinically, supplementing active vitamin D can treat intestinal inflammation. Mushroom powder also contains a variety of nutrients needed by the human body, such as vitamin D, minerals, protein, etc., and proper intake helps promote physical health. Vitamin D is a fat-soluble vitamin. Its main function is to promote the absorption of calcium and phosphorus by small intestinal mucosal cells, thereby preventing rickets, promoting skin cell growth, differentiation and regulating immune function. Studies have shown that there is a certain correlation between the lack of vitamin D in the breast and the increased incidence of breast cancer. Therefore, patients with breast nodules should supplement an appropriate amount of vitamin D in their daily lives to prevent the risk of breast cancer.

[0037] (1) The raw materials used in the food composition of the present invention are all medicine and food homologous substances, which have the advantages of high safety and no side effects.

[0038] (2) The ingredients of the food composition of the present invention have clear meridians in the human body. Through the "disturbance and activation" effects of double red rose, hawthorn, dandelion and bergamot; the "benefit and supplement" effects of Codonopsis, Astragalus, Maca, Polygonatum and American ginseng; the "softening and dispersing" effect of kelp; and the "regulating" effect of galactomannan, Eucommia leaf and mushroom powder, the synergistic effect of each component can achieve the technical effect of significantly improving the constitution of qi stagnation and blood stasis and preventing and treating breast nodule hyperplasia.

[0039] (3) The medicinal and edible components with "benefiting and replenishing" effects of the present invention all use sweet ingredients, combined with double red rose, hawthorn and dandelion ingredients, and through a specific puffing and extraction process, the smell of the composition can be synergistically adjusted, significantly enhancing the taste acceptability. DETAILED DESCRIPTION

[0040] The present invention is further described in detail below in conjunction with examples, but the embodiments of the present invention are not limited thereto.

[0041] Example 1

[0042] A food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodular hyperplasia is prepared from the following raw material components in parts by weight:

[0043] 30 parts of double red rose flowers, 25 parts of hawthorns, 20 parts of dandelions, 20 parts of galactomannan, 24 parts of codonopsis pilosula, 18 parts of astragalus, 18 parts of maca, 18 parts of polygonatum, 12 parts of bergamot, 12 parts of eucommia leaves, 12 parts of kelp, 6 parts of American ginseng, and 0.5 part of mushroom powder.

[0044] The food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodule hyperplasia is prepared by the following method:

[0045] (1) Weigh the raw materials according to the above weight ratio for use, wash the double red rose, hawthorn and eucommia leaves, remove the core of the hawthorn, sterilize them, place them in an oven to dry at 80° C., control the moisture content to 6%, and then pulverize them through an 80-mesh sieve to obtain material A.

[0046] (2) After cleaning and sterilization, dandelion, codonopsis, astragalus, maca, polygonatum, citron, kelp, American ginseng and mushroom powder are placed in an oven for drying at 80°C, with the moisture content controlled at 6%, and then crushed and sieved through a 200-mesh sieve. Then, they are placed in a screw extruder for expansion at 90°C, with a screw speed of 180 r / min, and an expansion time of 3 h. Then, 6 times the amount of water is added for immersion in ultrasound, with the power set to 150 w for 2 h, and then decocted for a total of 3 h. The decoction is repeated 3 times, and the mixture is concentrated under reduced pressure to a thick paste. After drying at 80°C, the mixture is crushed and sieved through an 80-mesh sieve to obtain material B.

[0047] (3) Galactomannan is made from natural guar beans. Through a series of processes such as enzymatic hydrolysis, separation and purification, and drying, the high molecular weight galactomannan polysaccharide (~2000 kDa) in the guar beans is degraded into short-chain, low-polymerization galactomannan polysaccharide with a molecular weight of 20 to 30 kDa.

[0048] (4) After passing material A, material B and galactomannan through a 40-mesh vibrating screen, add them into a three-dimensional mixer for mixing. The mixing time is controlled at 35 min, the mixing frequency is controlled at 25 Hz, the temperature is 20° C., and the relative humidity is controlled at 50%. The materials are completely mixed to obtain a powder.

[0049] Example 2

[0050] A food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodular hyperplasia is prepared from the following raw material components in parts by weight:

[0051] 20 parts of double red rose flowers, 30 parts of hawthorns, 10 parts of dandelions, 10 parts of galactomannan, 15 parts of codonopsis pilosula, 20 parts of astragalus, 20 parts of maca, 15 parts of polygonatum, 10 parts of bergamot, 10 parts of eucommia leaves, 10 parts of kelp, 5 parts of American ginseng, and 0.4 part of mushroom powder.

[0052] The food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodule hyperplasia is prepared by the following method:

[0053] (1) Weigh the raw materials according to the above weight ratios for use, wash the double red rose, hawthorn and eucommia leaves, remove the core of the hawthorn, sterilize them, place them in an oven to dry at 80° C., control the moisture content to 5%, and then crush and sieve through a 100-mesh sieve to obtain material A.

[0054] (2) After cleaning and sterilizing dandelion, codonopsis, astragalus, maca, polygonatum, citron, kelp, American ginseng and mushroom powder, they were placed in an oven for drying at 80°C and the moisture content was controlled to 5%. They were then crushed and sieved through a 200-mesh sieve. They were then placed in a screw extruder for puffing at a temperature of 100°C and a screw speed of 150 r / min for a puffing time of 2 h. Then, 4 times the amount of water was added for immersion in ultrasound at a power of 150 W for 3 h. The mixture was then decocted for a total of 4 h. The mixture was decocted 3 times and concentrated under reduced pressure to a thick paste. The mixture was dried at 80°C and crushed and passed through a 100-mesh sieve to obtain material B.

[0055] (3) Galactomannan is made from natural guar beans. Through a series of processes such as enzymatic hydrolysis, separation and purification, and drying, the high molecular weight galactomannan polysaccharide (~2000 kDa) in the guar beans is degraded into short-chain, low-polymerization galactomannan polysaccharide with a molecular weight of 20 to 30 kDa.

[0056] (4) Material A, material B and galactomannan are passed through a 40-mesh vibrating sieve and then mixed with a binder to obtain granules.

[0057] Example 3

[0058] A food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodular hyperplasia is prepared from the following raw material components in parts by weight:

[0059] 40 parts of double red rose flowers, 20 parts of hawthorns, 30 parts of dandelions, 30 parts of galactomannan, 30 parts of codonopsis pilosula, 15 parts of astragalus, 15 parts of maca, 20 parts of polygonatum, 15 parts of bergamot, 5 parts of eucommia leaves, 15 parts of kelp, 8 parts of American ginseng, and 0.8 part of mushroom powder.

[0060] The food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodule hyperplasia is prepared by the following method:

[0061] (1) Weigh the raw materials according to the above weight ratio for use, wash the double red rose and eucommia leaves, remove the core of the hawthorn, sterilize them, place them in an oven to dry at 80° C., control the moisture content to 7%, and then crush and sieve through a 100-mesh sieve to obtain material A.

[0062] (2) After cleaning and sterilizing dandelion, codonopsis, astragalus, maca, bergamot, kelp, American ginseng and mushroom powder, they were placed in an oven for drying at 80°C, with the moisture content controlled at 7%, and then crushed and sieved through a 200-mesh sieve. They were then placed in a screw extruder for expansion at 80°C, with a screw speed of 200 r / min, and an expansion time of 4 h. Then, 8 times the amount of water was added for immersion in ultrasound, with the power set to 150 w for 3 h, and then decocted for a total of 1 h. The decoction was repeated 3 times, and the mixture was concentrated under reduced pressure to a thick paste. The mixture was dried at 80°C and crushed, and passed through a 100-mesh sieve to obtain material B.

[0063] (3) Galactomannan is made from natural guar beans. Through a series of processes such as enzymatic hydrolysis, separation and purification, and drying, the high molecular weight galactomannan polysaccharide (~2000 kDa) in the guar beans is degraded into short-chain, low-polymerization galactomannan polysaccharide with a molecular weight of 20 to 30 kDa.

[0064] (4) After passing material A, material B and galactomannan through a 40-mesh vibrating screen, add them into a three-dimensional mixer for mixing. The mixing time is controlled at 35 min, the mixing frequency is controlled at 25 Hz, the temperature is 20° C., and the relative humidity is controlled at 50%. The materials are completely mixed and uniformly mixed. After the powder is obtained, it is mixed with a binder, a disintegrant, and a flavor regulator (such as fruit powder, a sweetener or an acidity regulator) and compressed into tablets to obtain tablets.

[0065] Comparative Example 1

[0066] The food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodule hyperplasia in this comparative example does not contain double red rose, hawthorn, dandelion and bergamot components as in Example 1, and the rest is the same.

[0067] Comparative Example 2

[0068] The food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodule hyperplasia in this comparative example does not contain galactomannan, eucommia leaf and mushroom powder components as compared with Example 1, and the rest are the same.

[0069] Comparative Example 3

[0070] The food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodule hyperplasia in this comparative example is not puffed during the preparation of material B compared with Example 1, and the rest is the same.

[0071] 1. The conditioning performance of the food composition obtained in Example 1 and Comparative Examples 1 to 3 of the present invention was tested by self-evaluation of the subjects. 80 female patients aged 25 to 45 years old and clinically diagnosed with breast nodule hyperplasia were recruited and randomly divided into 4 groups, 20 people in each group, and the food compositions of Example 1 and Comparative Examples 1 to 3 were taken for 1 month, 3 times a day, after meals, 10g each time, and taken after warm water. No other therapeutic drugs were taken during the test period and 1 month before and after. The proportion of significantly improved mood depression and significantly improved breast nodules was statistically analyzed, and the test results are shown in Table 1 below.

[0072] Table 1

[0073]

[0074] From the results in Table 1, it can be seen that the lack of the "dispersing and activating" effects of double red roses, hawthorn, dandelion and bergamot and the "regulating" effects of galactomannan, eucommia leaves and mushroom powder, the corresponding effects of improving qi stagnation and blood stasis and preventing and treating breast nodule hyperplasia are significantly reduced. At the same time, the components of codonopsis, astragalus, maca, polygonatum and American ginseng, which have the effects of "benefiting and replenishing", are extracted by ultrasonic treatment after puffing, which is conducive to further improving the conditioning effect of the obtained food composition.

[0075] 2. The taste acceptability of the food compositions obtained in Example 1 and Comparative Examples 1 to 3 of the present invention was tested by self-evaluation by test subjects. The testers were the same as above. The test results are shown in Table 2 below.

[0076] Table 2

[0077]

[0078] It can be seen from the results in Table 2 that the smell and taste can be significantly improved by adding double red roses, hawthorns and dandelions; the taste can be improved to a certain extent by adding galactomannan components; and the smell and taste of the food composition can be improved most significantly by extracting the core "benefiting and replenishing" components after puffing.

[0079] The above embodiments are preferred implementation modes of the present invention, but the implementation modes of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications that do not deviate from the spirit and principles of the present invention should be equivalent replacement methods and are included in the protection scope of the present invention.

Claims

1. A food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodule hyperplasia, characterized in that: Prepared from the following raw material components by weight: 20-40 parts of double-petal red roses, 20-30 parts of hawthorns, 10-30 parts of dandelions, 10-30 parts of galactomannan, 15-30 parts of codonopsis pilosula, 15-20 parts of astragalus, 15-20 parts of maca, 15-20 parts of polygonatum, 10-15 parts of bergamot, 10-15 parts of kelp, 5-10 parts of eucommia leaves, 5-8 parts of American ginseng, and 0.1-1 part of mushroom powder.

2. A food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodular hyperplasia according to claim 1, characterized in that: The galactomannan is made from natural guar beans as raw materials. The high molecular weight galactomannan polysaccharide in the guar beans is degraded through enzymatic hydrolysis, separation and purification, and drying processes to obtain a short-chain galactomannan with a molecular weight of 20 to 30 kDa and a low degree of polymerization.

3. A method for preparing a food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodular hyperplasia according to claim 1 or 2, characterized in that: The method comprises the following preparation steps: (1) washing double red roses, hawthorn and eucommia leaves respectively, removing the core of hawthorn, sterilizing, drying, crushing and sieving to obtain material A; (2) washing and sterilizing dandelion, codonopsis, astragalus, maca, polygonatum, citron, kelp, American ginseng and mushroom powder, drying, crushing and sieving, and then puffing, adding water for ultrasonic immersion, and then decocting, reducing pressure and concentrating to a thick paste, and continuing to dry and crushing and sieving to obtain material B; (3) Raw material A, raw material B and galactomannan are mixed to obtain the food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodule hyperplasia.

4. The method for preparing a food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodular hyperplasia according to claim 3, characterized in that: The drying in step (1) refers to drying at a temperature of 70-90° C. until the weight percentage of moisture in the material is 5%-7%, and the crushing and screening refers to passing through an 80-100 mesh sieve after crushing.

5. The method for preparing a food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodular hyperplasia according to claim 3, characterized in that: The drying, crushing and screening after cleaning and sterilization in step (2) refers to drying the material at a temperature of 70 to 90° C. until the material has a moisture content of 5% to 7% by weight, and then crushing and screening through a 180 to 200 mesh sieve.

6. The method for preparing a food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodular hyperplasia according to claim 3, characterized in that: The puffing treatment in step (2) refers to puffing treatment in a screw extruder, the puffing temperature is 80-100° C., the screw speed is 150-200 r / min, and the time is 2-4 h.

7. The method for preparing a food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodular hyperplasia according to claim 3, characterized in that: The amount of water added in step (2) is 4 to 8 times the mass of the material; the ultrasonic power of the ultrasonic immersion treatment is 120 to 180 W, and the time is 2 to 3 hours.

8. The method for preparing a food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodular hyperplasia according to claim 3, characterized in that: The decoction time in step (2) is 1 to 4 hours; the further drying followed by crushing and screening refers to drying at a temperature of 70 to 90° C. and then crushing and passing through a sieve of 80 to 100 meshes.

9. The method for preparing a food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodular hyperplasia according to claim 3, characterized in that: The mixed preparation in step (3) is further added with auxiliary materials or carriers to be prepared into powders, tablets, pills, granules, capsules, and oral liquids.

10. The method for preparing a food composition for improving qi stagnation and blood stasis constitution and preventing and treating breast nodular hyperplasia according to claim 9, characterized in that: The auxiliary material or carrier includes at least one of a diluent, a binder, a dispersant, a lubricant, a disintegrant, a solvent, and a flavor regulator.

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