A device for sonodynamic treatment of brain glioma

Abstract

The present invention relates to the field of sonodynamic therapy technology, and more specifically, to a device for sonodynamic therapy of gliomas. The device comprises an image guidance module, a treatment planning module, an ultrasonic drive module, an ultrasonic mechanism, and a fixation module. The treatment planning module calculates the ultrasonic energy required for sonodynamic therapy of gliomas at different locations and corrects the theoretical energy value based on the actual measured energy. In this application, ultrasonic irradiation of the head is performed using image guidance, and the energy of the ultrasonic emission is adaptively adjusted according to the different irradiation locations to ensure the safety and effectiveness of the treatment.

Description

Technical Field

[0001] The present invention relates to the technical field of sonodynamic therapy, and in particular to a device for sonodynamic therapy of brain gliomas. Background Art

[0002] Glioma is the most common central nervous system tumor in neurosurgery, accounting for about 46% of intracranial tumors. Currently, the mainstream clinical treatments for glioma include radiotherapy, chemotherapy and surgery, but all have certain defects. Among them, surgery is the most important means of treating glioma, but surgery usually cannot completely remove the tumor, and it needs to be combined with radiotherapy and chemotherapy. However, radiotherapy and chemotherapy use radiation or chemical drugs to kill tumor cells and inhibit tumor growth. Their treatment has poor targeting. While killing tumor cells, they also cause serious damage to normal cells, and repeated treatments cannot be performed in the short term. Therefore, there is a need for a non-invasive or minimally invasive, repeatable glioma treatment device that can kill glioma cells while maintaining brain structure and function to the greatest extent. Summary of the Invention

[0003] In view of this, the object of the present invention is to provide a device for sonodynamic treatment of brain gliomas to overcome the problems existing in the current prior art.

[0004] To achieve the above objectives, the present invention adopts the following technical solutions:

[0005] The present application provides a device for sonodynamic treatment of brain glioma, comprising: an image guidance module, a treatment planning module, an ultrasonic driving module, an ultrasonic mechanism for performing ultrasonic treatment on a patient, and a fixing module for fixing the ultrasonic mechanism to the head;

[0006] The image guidance module is connected to the treatment planning module, the treatment planning module is connected to the ultrasonic driving module via a serial port or a CAN bus, the ultrasonic driving module is connected to the ultrasonic mechanism, and the ultrasonic mechanism is fixed to the fixing module;

[0007] The image guidance module is configured to receive a head image of a patient, register the head image, reconstruct a three-dimensional image of the patient's head, and obtain a Hounsfield value for each voxel point in the three-dimensional image;

[0008] The treatment planning module is configured to calculate the sound velocity and sound attenuation coefficient of each part of the skull and brain tissue according to the Hounsfield value of each voxel point in the three-dimensional image, and adaptively adjust the transmission energy of the ultrasonic mechanism according to the sound velocity and the sound attenuation coefficient;

[0009] The ultrasonic driving module is used to drive the ultrasonic mechanism according to the adjusted transmission energy;

[0010] The ultrasonic mechanism is used to emit ultrasonic energy;

[0011] The fixing module is used to fix the ultrasonic mechanism so that the ultrasonic energy irradiates the target area, causing the sonosensitizer enriched in the target area to produce substances such as reactive oxygen species, thereby killing tumor cells.

[0012] Furthermore, in the above-mentioned device, the image guidance module receives a head image of a patient who has been intravenously injected with a sonosensitizer for more than 24 hours; wherein, the sonosensitizer can generate reactive oxygen species under the action of ultrasound.

[0013] Furthermore, in the above-mentioned device, the head image includes: an MRI head image of the patient and a CT head image of the patient.

[0014] Furthermore, in the above-mentioned device, the ultrasonic mechanism is composed of multiple ultrasonic array elements composed of piezoelectric ceramic materials, and ultrasonic waves of different energy levels are generated by exciting different piezoelectric ceramic materials with electrical signals of different sizes.

[0015] Furthermore, in the above-mentioned device, the treatment planning module includes: an ultrasound energy theoretical calculation unit and an energy comparison correction unit;

[0016] The ultrasonic energy theoretical calculation unit is used to calculate the sound velocity and sound attenuation coefficient of each part of the skull and brain tissue based on the Hounsfield value of each voxel point in the three-dimensional image, determine the treatment target area according to the image guidance module, determine the position of the ultrasonic mechanism according to the fixation module, determine the sound propagation path of each of the ultrasonic array elements according to the treatment target area and the position of the ultrasonic mechanism, and determine the energy attenuation parameter of the sound propagation path based on the sound propagation path, the sound velocity and sound attenuation coefficient of each part of the skull and brain tissue, calculate the remaining energy of a single ultrasonic array element based on the energy attenuation parameter, and calculate the theoretical value of the energy required for the target area based on the sound field superposition principle;

[0017] The energy comparison and correction unit is used to perform actual sound field measurement through a hydrophone to obtain an actual measured energy value, correct the theoretical value according to the actual measured energy value, and determine the emission energy according to the corrected theoretical value.

[0018] The beneficial effects of the present invention are:

[0019] The present application comprises an image guidance module, a treatment planning module, an ultrasonic driving module, an ultrasonic mechanism for performing ultrasonic treatment on a patient, and a fixing module for fixing the ultrasonic mechanism to the head. The image guidance module is connected to the treatment planning module, which is connected to the ultrasonic driving module via a serial port or a CAN bus. The ultrasonic driving module is connected to the ultrasonic mechanism, and the ultrasonic mechanism is fixed to the fixing module. The image guidance module receives a head image of the patient, registers the head image, reconstructs a three-dimensional image of the patient's head, and obtains the Hounsfield value of each voxel point in the three-dimensional image. The treatment planning module calculates the sound velocity and acoustic attenuation coefficient of each part of the skull and brain tissue based on the Hounsfield value of each voxel point in the three-dimensional image, and adaptively adjusts the transmission energy of the ultrasonic mechanism based on the sound velocity and acoustic attenuation coefficient. The ultrasonic driving module drives the ultrasonic mechanism according to the adjusted transmission energy, and the ultrasonic mechanism transmits ultrasonic energy. The fixing module fixes the ultrasonic mechanism so that the ultrasonic energy irradiates the target area with ultrasonic energy, causing the sonosensitizer enriched in the target area to produce substances such as reactive oxygen species, thereby killing tumor cells. In the present application, the treatment planning module can adaptively adjust the transmission energy of each ultrasonic array in the ultrasonic mechanism according to the position of the target area and the ultrasonic mechanism. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0021] Figure 1 This is a structural schematic diagram provided by an embodiment of a device for sonodynamic treatment of brain gliomas according to the present invention. DETAILED DESCRIPTION

[0022] To make the objectives, technical solutions, and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. Obviously, the embodiments described are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other implementations obtained by those of ordinary skill in the art without inventive effort are within the scope of protection of the present invention.

[0023] The present invention also provides a device for sonodynamic treatment of brain gliomas, which is used to implement the above method embodiment. Figure 1 FIG. 1 is a schematic diagram of a structure of an embodiment of a device for sonodynamic treatment of glioma according to the present invention. Figure 1 As shown, this embodiment includes:

[0024] An image guidance module 1, a treatment planning module 2, an ultrasonic driving module 3, an ultrasonic mechanism 4 for performing ultrasonic treatment on a patient, and a fixing module 5 for fixing the ultrasonic mechanism 4 to the head;

[0025] The image guidance module 1 is connected to the treatment planning module 2, the treatment planning module 2 is connected to the ultrasonic driving module 3 via a serial port or a CAN bus, the ultrasonic driving module 3 is connected to the ultrasonic mechanism 4, and the ultrasonic mechanism 4 is fixed on the fixing module 5;

[0026] Image guidance module 1, for receiving a head image of a patient, registering the head image, reconstructing a three-dimensional image of the patient's head, and obtaining the Hounsfield value of each voxel point in the three-dimensional image;

[0027] Treatment planning module 2, for calculating the sound velocity and sound attenuation coefficient of each part of the skull and brain tissue according to the Hounsfield value of each voxel point in the three-dimensional image, and adaptively adjusting the transmission energy of the ultrasonic mechanism 4 according to the sound velocity and sound attenuation coefficient;

[0028] The ultrasonic driving module 3 is used to drive the ultrasonic mechanism 4 according to the adjusted transmission energy;

[0029] Ultrasonic mechanism 4, for emitting ultrasonic energy;

[0030] The fixing module 5 is used to fix the ultrasonic mechanism 4 so that the ultrasonic energy irradiates the target area, causing the sonosensitizer enriched in the target area to produce substances such as active oxygen, thereby killing tumor cells.

[0031] Preferably, the image guidance module 1 receives a head image of a patient who has been intravenously injected with a sonosensitizer for more than 24 hours; wherein the sonosensitizer can generate reactive oxygen species under the action of ultrasound.

[0032] It is understandable that for patients with brain glioma, a sonosensitizer that can produce reactive oxygen species under the action of ultrasound is injected intravenously and waited for more than 24 hours to circulate in the body so that the sonosensitizer is enriched near the tumor.

[0033] Preferably, the head image includes: an MRI head image of the patient and a CT head image of the patient.

[0034] Preferably, the ultrasonic mechanism 4 is composed of a plurality of ultrasonic array elements composed of piezoelectric ceramic materials, and generates ultrasonic waves of different energy levels by exciting different piezoelectric ceramic materials with electric signals of different sizes.

[0035] It can be understood that the image guidance module 1 is connected to the treatment planning module 2. The image guidance module 1 includes the import of head MRI and CT images, MRI and CT image registration, three-dimensional reconstruction of the head and acquisition of the Hounsfield value H of each voxel point in the three-dimensional image; the treatment planning module 2 is connected and communicated with the ultrasonic driving module 3 through a serial port or a CAN bus. The treatment planning module 2 includes calculating the sound velocity and acoustic attenuation coefficient of each part of the skull and brain tissue according to the Hounsfield value H of each voxel point in the three-dimensional skull reconstruction image, and adaptively adjusting the emission energy of the ultrasonic mechanism 4 for treating the patient according to the above acoustic parameters; the ultrasonic driving module 3 is connected and communicated with the patient through a serial port or a CAN bus. The ultrasonic mechanism 4 is connected, and the ultrasonic emission energy calculated by the treatment plan module 2 is used to drive the ultrasonic mechanism 4 for performing ultrasonic treatment on the patient; the ultrasonic mechanism 4 for performing ultrasonic treatment on the patient is fixed to the patient's head by a fixing module 5 that fixes the ultrasonic mechanism 4 to the head. The ultrasonic mechanism 4 for performing ultrasonic treatment on the patient mainly includes an array composed of multiple piezoelectric ceramic materials, and different piezoelectric ceramic materials are excited by electrical signals of different sizes, thereby generating ultrasonic waves of different energy sizes; the fixing module 5 that fixes the ultrasonic mechanism 4 to the head includes a fixing device that adapts to the shape of the head, which is used to fix the ultrasonic mechanism 4 for performing ultrasonic treatment on the patient.

[0036] Preferably, the treatment planning module 2 includes: an ultrasound energy theoretical calculation unit and an energy control correction unit;

[0037] an ultrasonic energy theoretical calculation unit, configured to calculate the sound velocity and acoustic attenuation coefficient of various parts of the skull and brain tissue based on the Hounsfield value of each voxel point in the three-dimensional image, determine the treatment target area based on the image guidance module 1, determine the position of the ultrasonic mechanism 4 based on the fixation module 5, determine the acoustic propagation path of each ultrasonic array element based on the treatment target area and the position of the ultrasonic mechanism 4, determine the energy attenuation parameter of the acoustic propagation path based on the acoustic propagation path, the sound velocity and acoustic attenuation coefficient of various parts of the skull and brain tissue, calculate the remaining energy of a single ultrasonic array element based on the energy attenuation parameter, and calculate the theoretical value of the energy required for the target area based on the principle of sound field superposition;

[0038] The energy comparison and correction unit is used to obtain the actual measured energy value by performing actual sound field measurement through the hydrophone, correct the theoretical value according to the actual measured energy value, and determine the emission energy according to the corrected theoretical value.

[0039] It can be understood that the same or similar parts of the above embodiments can be referenced to each other, and the contents not described in detail in some embodiments can refer to the same or similar contents in other embodiments.

[0040] It should be noted that, in the description of the present invention, the terms "first", "second", etc. are used for descriptive purposes only and should not be understood as indicating or implying relative importance. In addition, in the description of the present invention, unless otherwise specified, the meaning of "plurality" is at least two.

[0041] Any process or method description in a flowchart or otherwise described herein may be understood to represent a module, segment or portion of code comprising one or more executable instructions for implementing the steps of a specific logical function or process, and the scope of the preferred embodiments of the present invention includes alternative implementations in which functions may be performed out of the order shown or discussed, including performing functions in a substantially simultaneous manner or in the reverse order depending on the functions involved, which should be understood by those skilled in the art to which the embodiments of the present invention pertain.

[0042] It should be understood that various parts of the present invention can be implemented using hardware, software, firmware, or a combination thereof. In the above-described embodiments, multiple steps or methods can be implemented using software or firmware stored in a memory and executed by a suitable instruction execution system. For example, if implemented using hardware, as in another embodiment, any one of the following technologies known in the art or a combination thereof can be used: a discrete logic circuit having a logic gate circuit for implementing a logic function on a data signal, an application-specific integrated circuit having a suitable combination of logic gate circuits, a programmable gate array (PGA), a field programmable gate array (FPGA), etc.

[0043] Those skilled in the art will understand that all or part of the steps in the method of the above embodiment can be completed by instructing related hardware through a program, and the program can be stored in a computer-readable storage medium. When the program is executed, it includes one or a combination of the steps of the method embodiment.

[0044] In addition, the functional units in the various embodiments of the present invention may be integrated into a single processing module, or each unit may exist physically separately, or two or more units may be integrated into a single module. The aforementioned integrated modules may be implemented in the form of hardware or in the form of software functional modules. If the integrated modules are implemented in the form of software functional modules and sold or used as independent products, they may also be stored in a computer-readable storage medium.

[0045] The storage medium mentioned above can be a read-only memory, a magnetic disk or an optical disk, etc.

[0046] Throughout this specification, reference to terms such as "one embodiment," "some embodiments," "examples," "specific examples," or "some examples" means that a specific feature, structure, material, or characteristic described in conjunction with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0047] Although the embodiments of the present invention have been shown and described above, it will be understood that the above embodiments are illustrative and are not to be construed as limitations on the present invention. A person skilled in the art may change, modify, replace and modify the above embodiments within the scope of the present invention.

Claims

1. A device for sonodynamic treatment of glioma, characterized in that: include: An image guidance module, a treatment planning module, an ultrasonic driving module, an ultrasonic mechanism for performing ultrasonic treatment on a patient, and a fixing module for fixing the ultrasonic mechanism to the head; The image guidance module is connected to the treatment planning module, the treatment planning module is connected to the ultrasonic driving module via a serial port or a CAN bus, the ultrasonic driving module is connected to the ultrasonic mechanism, and the ultrasonic mechanism is fixed to the fixing module; The image guidance module is configured to receive a head image of a patient, register the head image, reconstruct a three-dimensional image of the patient's head, and obtain a Hounsfield value for each voxel point in the three-dimensional image; The treatment planning module is configured to calculate the sound velocity and sound attenuation coefficient of each part of the skull and brain tissue according to the Hounsfield value of each voxel point in the three-dimensional image, and adaptively adjust the transmission energy of the ultrasonic mechanism according to the sound velocity and the sound attenuation coefficient; The ultrasonic driving module is used to drive the ultrasonic mechanism according to the adjusted transmission energy; The ultrasonic mechanism is used to emit ultrasonic energy; The fixing module is used to fix the ultrasonic mechanism so that the ultrasonic energy irradiates the target area, causing the sonosensitizer enriched in the target area to produce substances such as reactive oxygen species, thereby killing tumor cells; The ultrasonic mechanism is composed of multiple ultrasonic array elements made of piezoelectric ceramic materials, which generate ultrasonic waves of different energy levels by exciting different piezoelectric ceramic materials with electrical signals of different sizes. The treatment planning module includes: an ultrasound energy theoretical calculation unit and an energy comparison correction unit; The ultrasonic energy theoretical calculation unit is used to calculate the sound velocity and sound attenuation coefficient of each part of the skull and brain tissue based on the Hounsfield value of each voxel point in the three-dimensional image, determine the treatment target area according to the image guidance module, determine the position of the ultrasonic mechanism according to the fixation module, determine the sound propagation path of each of the ultrasonic array elements according to the treatment target area and the position of the ultrasonic mechanism, and determine the energy attenuation parameter of the sound propagation path based on the sound propagation path, the sound velocity and sound attenuation coefficient of each part of the skull and brain tissue, calculate the remaining energy of a single ultrasonic array element based on the energy attenuation parameter, and calculate the theoretical value of the energy required for the target area based on the sound field superposition principle; The energy comparison and correction unit is used to perform actual sound field measurement through a hydrophone to obtain an actual measured energy value, correct the theoretical value according to the actual measured energy value, and determine the emission energy according to the corrected theoretical value.

2. The device according to claim 1, characterized in that The image guidance module receives a head image of a patient who has been intravenously injected with a sonosensitizer for more than 24 hours; wherein the sonosensitizer can generate reactive oxygen species under the action of ultrasound.

3. The device according to claim 2, characterized in that The head image includes: an MRI head image of the patient and a CT head image of the patient.

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