Scutellaria baicalensis enema No.2 and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, and particularly discloses radix scutellariae enema liquid No.2 and a preparation method thereof.The radix scutellariae enema liquid No.2 is prepared from, by weight, 25-35 g of cortex phellodendri, 15-25 g of fructus forsythiae, 15-25 g of herba taraxaci, 20-30 g of radix et rhizoma rhei, 15-25 g of radix scutellariae, 25-35 g of radix sanguisorbae, 25-35 g of radix sophorae flavescentis, 15-25 g of flos lonicerae, 15-25 g of cacumen biotae charcoal, 10-20 g of indigo naturalis and 3-8 g of mirabilite. The preparation method comprises the following steps: soaking the raw materials in water for 15-25 minutes in a traditional Chinese medicine decocting machine, extracting for 35-45 minutes under micro pressure, subpackaging into packaging bags, sterilizing for 25-35 minutes at the high temperature of 100 DEG C, and storing in a dark place at the low temperature of 20 DEG C or below. The traditional Chinese medicine preparation has the beneficial effects that through the pharmacological action and comprehensive action of the traditional Chinese medicinal materials, the effects of clearing away heat and toxic materials, purging intense heat and drying dampness, relieving pain and eliminating stagnation, cooling blood and stopping bleeding, astringing to arrest diarrhea, purging heat and relaxing bowels, moistening dryness and softening hard mass and the like can be achieved; the traditional Chinese medicine composition is suitable for patients with symptoms such as intestinal mucosa erosion, ulcer formation, more hemorrhagic spots and more purulent bloody stool caused by chronic non-specific ulcerative colitis, and the treatment effect is remarkable.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine compositions, in particular to Scutellaria baicalensis enema solution No. 2 and a preparation method thereof. Background Art

[0002] As is known, chronic nonspecific ulcerative colitis is an intestinal inflammatory disease of unknown etiology, which often causes abdominal pain, diarrhea, blood in the stool and other symptoms, seriously affecting the quality of life of patients. Existing treatment methods mostly rely on immunosuppressants, anti-inflammatory drugs, etc., but long-term use has obvious side effects and a high recurrence rate.

[0003] The prior art lacks a Chinese patent medicine that directly acts on intestinal lesions and is suitable for treating patients with chronic nonspecific ulcerative colitis who have symptoms such as intestinal mucosal erosion, ulcer formation, more bleeding spots, and more bloody stools. To this end, a Scutellaria baicalensis enema solution No. 2 and a preparation method thereof are proposed. Summary of the invention

[0004] In order to effectively solve the problems in the background technology and overcome the technical defects in the prior art, the present invention provides the following technical solutions:

[0005] Scutellaria baicalensis enema solution No. 2 is prepared from the following raw material medicinal components in weight ratio: Phellodendron chinense 25-35g, Forsythia suspensa 15-25g, Taraxacum mongolicum 15-25g, Rhubarb 20-30g, Scutellaria baicalensis 15-25g, Sanguisorba officinalis 25-35g, Sophora flavescens 25-35g, Lonicera japonica 15-25g, Platycladus orientalis charcoal 15-25g, Indigo naturalis 10-20g, and Sophora japonica salt 3-8g.

[0006] As a preferred technical solution of the present invention, it is made of the following raw material drug components in the following weight ratio: 25g of Phellodendron chinense, 15g of Forsythia suspensa, 15g of Taraxacum mongolicum, 20g of Rhubarb, 15g of Scutellaria baicalensis, 25g of Sanguisorba officinalis, 2g of Sophora flavescens, 15g of Lonicera japonica, 15g of Platycladus orientalis charcoal, 10g of Indigo naturalis, and 3g of Sodium sulfate.

[0007] As a preferred technical solution of the present invention, it is made of the following raw material drug components in the following weight ratio: 30g of Phellodendron chinense, 20g of Forsythia suspensa, 20g of Taraxacum mongolicum, 25g of Rhubarb, 20g of Scutellaria baicalensis, 30g of Sanguisorba officinalis, 30g of Sophora flavescens, 20g of Lonicera japonica, 20g of Platycladus orientalis charcoal, 15g of Indigo naturalis, and 5g of Sodium sulfate.

[0008] As a preferred technical solution of the present invention, it is made of the following raw material drug components in the following weight ratio: 35g of Phellodendron chinense, 25g of Forsythia suspensa, 25g of Taraxacum mongolicum, 30g of Rhubarb, 25g of Scutellaria baicalensis, 35g of Sanguisorba officinalis, 35g of Sophora flavescens, 25g of Lonicera japonica, 25g of Platycladus orientalis charcoal, 20g of Indigo naturalis, and 8g of Sodium sulfate.

[0009] The preparation method of Scutellaria baicalensis enema solution No. 2 comprises the following steps:

[0010] Step 1: Take the above medicinal materials in corresponding proportions according to the weight ratio, wash and set aside;

[0011] Step 2: Dry the washed medicinal materials in step 1 using a drying device and put them into medicine bags for decoction;

[0012] Step 3: Place the medicine bag filled with medicinal materials in step 2 into a Chinese medicine decoction machine, add an appropriate amount of water to soak for 15-25 minutes, and extract under slight pressure for 35-45 minutes;

[0013] Step 4: Pack the liquid medicine extracted in step 3 into packaging bags and sterilize them at 100° C. for 25-35 minutes to complete the preparation of Scutellaria baicalensis enema solution No. 2.

[0014] As a preferred technical solution of the present invention, the capacity of the packaging bag in step three is 100 ml.

[0015] As a preferred technical solution of the present invention, the drug solution prepared in step 4 and packaged in the packaging bags is stored in a low temperature environment below 20° C. away from light.

[0016] Compared with the prior art, the beneficial effects of the present invention are: through the pharmacological effects and comprehensive effects of various Chinese medicinal materials, it can achieve the effects of clearing away heat and detoxifying, purging fire and drying dampness, relieving pain and dispersing knots, cooling blood and stopping bleeding, astringing and stopping diarrhea, purging heat and promoting bowel movements, and moistening dryness and softening hard masses; it is suitable for patients with chronic nonspecific ulcerative colitis who have symptoms such as intestinal mucosal erosion, ulcer formation, more bleeding spots, and more bloody stools, and the therapeutic effect is significant.

[0017] The medicinal properties and effects of each drug in the present invention are as follows:

[0018] Huangbai: bitter in taste, cold in nature, enters the kidney meridian, bladder meridian, and large intestine meridian. Functions and indications: clearing away heat and detoxifying, purging fire and drying dampness. It is mainly used to treat acute bacterial dysentery, acute enteritis, acute icteric hepatitis, urinary tract infection and other inflammations. It can be used externally to treat burns, otitis media, acute conjunctivitis, etc.

[0019] Forsythia suspensa: bitter, slightly cold, enters the lung, heart and small intestine meridians; Functions and indications: clears away heat and detoxifies, reduces swelling and disperses nodules, used for carbuncle, scrofula, breast abscess, erysipelas, wind-heat cold, the initial stage of febrile disease, warm and heat entering the blood, high fever, thirst, coma and rash, and heat stranguria and urinary retention.

[0020] Dandelion: bitter and sweet, cold, enters the liver and stomach meridians. Functions and indications: clearing away heat and detoxifying, diuretic and dispersing nodules, treating acute mastitis, lymphadenitis, scrofula, carbuncle, acute conjunctivitis, cold and fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, and urinary tract infection.

[0021] Rhubarb: bitter in taste, cold in nature; enters the spleen, stomach, large intestine, liver, and heart meridians; Efficacy: has the effects of purging and attacking accumulation, clearing away heat and purging fire, cooling blood and detoxifying, removing blood stasis and dredging menstruation, and promoting dampness and jaundice; Indications: used for constipation due to excess heat accumulation, vomiting and bleeding due to blood heat, red eyes and swollen throat, carbuncle treatment, abdominal pain due to intestinal carbuncle, amenorrhea due to blood stasis, postpartum blood stasis, traumatic injuries, damp-heat dysentery, jaundice and red urine, stranguria, edema; external treatment of burns and scalds.

[0022] Scutellaria baicalensis: bitter in taste, cold in nature, can rise or fall, slightly yang in yin, non-toxic; enters the lung meridian and large intestine; Functions and indications: reduces fever and relieves restlessness, drains bladder fire, stops dysentery, eliminates red eyes, calms the fetus, relieves stagnation caused by typhoid fever, moisturizes dryness, and benefits the lung qi.

[0023] Sanguisorba officinalis: sour, non-toxic, cold in nature; enters the liver, lung, kidney, and large intestine meridians. Functions and indications: It has the functions of cooling blood and stopping bleeding, clearing away heat and detoxifying, promoting tissue regeneration and healing sores; treats bloody stools, bloody dysentery, hemorrhoidal bleeding, hematuria, metrorrhagia, carbuncles, sores, burns, and scalds.

[0024] Sophora flavescens: bitter in taste, cold in nature; enters the heart, liver, stomach, large intestine, and bladder meridians; functions and indications: clearing away heat and dampness, killing parasites, and promoting diuresis; used for heat dysentery, bloody stool, jaundice and urine retention, leucorrhea, vaginal swelling and itching, eczema, wet sores, skin itching, scabies and leprosy; external treatment of trichomoniasis vaginitis.

[0025] Honeysuckle: sweet in taste, cold in nature; enters the lung, heart, stomach and large intestine meridians; functions and indications: clears away heat and detoxifies, dispels wind-heat; used for exogenous wind-heat, fever due to febrile diseases, carbuncles, sore throat, and dysentery due to heat toxins.

[0026] Platycladus orientalis charcoal: bitter, astringent, cold. Efficacy: cooling blood, stopping bleeding, removing rheumatism, dispersing swelling and toxins. Indications: vomiting blood, epistaxis, hematuria, bloody dysentery, intestinal wind, metrorrhagia, rheumatic pain, bacterial dysentery, hypertension, cough, erysipelas, mumps, burns.

[0027] Indigo: bitter and sweet in taste, cold in nature, non-toxic, enters the liver and spleen meridians. Functions and indications: It has the functions of clearing away heat and detoxifying, cooling blood, and calming the nerves; it can treat rashes caused by warm toxins, vomiting and bleeding due to blood heat, chest pain and coughing up blood, mouth ulcers, mumps, throat numbness, and epilepsy in children.

[0028] Glauber's Salt: salty, bitter, cold in nature; enters the stomach and large intestine meridians; efficacy: laxative, softening and hardening, clearing away heat and purging fire; indications: used for stagnation of excess heat, dry and hard stool, sore throat, mouth ulcers, red and swollen eyes; external treatment for breast abscess, swollen and painful hemorrhoids.

[0029] The division and function analysis of the monarch, minister, assistant and envoy ingredients in the formula of the present invention are as follows:

[0030] King medicine:

[0031] Honeysuckle (silver flower), Forsythia suspensa:

[0032] Honeysuckle and Forsythia both have the effects of clearing away heat and detoxifying, and evacuating wind-heat. In the formula of the present invention, they play a major therapeutic role for heat-toxic diseases and are the core drugs in the formula. Heat-toxicity can cause a variety of symptoms, such as fever, sore throat, sores, swelling and toxicity, etc. Honeysuckle and Forsythia can effectively remove heat-toxicity and dissipate carbuncle. For example, in the early stage of treating carbuncle, furuncle and swelling caused by exogenous wind-heat cold or heat-toxicity accumulation, they can play a good role in detoxification and swelling.

[0033] Phellodendron chinense, Scutellaria baicalensis:

[0034] Phellodendron chinense clears away heat and dampness, purges fire and detoxifies, and is especially good at clearing dampness and heat in the lower part of the body; Scutellaria baicalensis clears away heat and dampness, purges fire and detoxifies, stops bleeding, and stabilizes pregnancy, and is good at clearing dampness and heat in the upper and middle parts of the body. The combination of the two enhances the power of clearing heat and dampness, purges fire and detoxifies, and can play a key role in the treatment of heat-toxic and dampness-induced diseases, so they can also be regarded as part of the main medicine. For example, for dysentery and diarrhea caused by dampness and heat, or high fever, irritability, jaundice and other symptoms caused by the intense heat and toxicity, Phellodendron chinense and Scutellaria baicalensis can greatly improve the condition.

[0035] Minister medicine

[0036] Dandelion, Sophora flavescens:

[0037] Dandelion clears away heat and detoxifies, reduces swelling and resolves knots, and relieves dampness and relieves stranguria. Sophora flavescens clears heat and dries dampness, kills insects, and acts as a diuretic. They assist the main medicine in enhancing the effects of clearing heat and detoxifying, and drying dampness. When heat and toxicity are accompanied by dampness, symptoms such as skin sores, eczema itching, and urinary incontinence appear, dandelion and sophora flavescens can help the main medicine to better exert its efficacy. For example, for skin sores caused by heat and toxicity, dandelion can help dissipate swelling and toxicity, while sophora flavescens can dry dampness and relieve itching.

[0038] Rhubarb, Glauber’s Salt:

[0039] Rhubarb has the functions of purgation, clearing away heat and purging fire, cooling blood and detoxifying, removing blood stasis and promoting menstruation, while Glauber's salt has the functions of purgation, laxative, moistening dryness, softening hard masses, clearing away fire and reducing swelling. The combination of the two has a strong purgative effect, which can make the heat toxins be excreted from the body through the stool. For Yangming Fu Shi syndromes such as excessive heat and toxins, dry stools, abdominal distension and pain, rhubarb and Glauber's salt can play the role of removing the old and bringing in the new, purging heat and detoxifying, and are an important part of the ministerial drugs that play the role of purgation and detoxification.

[0040] Adjuvant

[0041] Sanguisorba officinalis and Platycladus orientalis charcoal:

[0042] Sanguisorba officinalis cools blood and stops bleeding, detoxifies and heals sores, while Platycladus orientalis charcoal cools blood and stops bleeding. In the entire formula, they mainly play a role in stopping bleeding. Because the intense heat and toxicity may force blood to flow indiscriminately, leading to various bleeding symptoms, such as blood in the stool, blood in the urine, metrorrhagia, etc. Sanguisorba officinalis and Platycladus orientalis charcoal can prevent bleeding, and also have a certain detoxification effect, assisting the main and auxiliary drugs to exert the overall therapeutic effect. For example, in diseases such as intestinal wind bleeding caused by heat and toxicity, Sanguisorba officinalis and Platycladus orientalis charcoal can cool blood and stop bleeding, relieving bleeding symptoms.

[0043] Indigo:

[0044] Indigo can clear away heat and detoxify, cool blood and eliminate spots, and relieve fire and calm the nerves. It can assist the main medicine in clearing away heat and detoxifying, especially for symptoms such as heat toxin spots. At the same time, Indigo can also calm the nerves. When heat toxins disturb the mind and cause symptoms such as irritability and epilepsy, Indigo can play a certain auxiliary therapeutic role.

[0045] Assistant drug: There is no typical assistant drug component in this prescription. However, in a broad sense, the mutual compatibility and synergy of the drugs in the prescription enable the efficacy of the entire prescription to be exerted on the affected area, and it can also be considered that the drugs are assistants to each other. For example, the laxative effect of drugs such as rhubarb and mirabilite can guide pathogens such as heat and toxins to be expelled from the body, and to some extent play the role of "leading the meridians" and coordinating the overall action direction of the drugs. DETAILED DESCRIPTION

[0046] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution in the embodiment of the present invention will be further clearly and completely described below. Obviously, the described embodiment is only a part of the embodiment of the present invention, not all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0047] The invention provides a technical scheme: Scutellaria baicalensis enema solution No. 2 is prepared from the following raw material drug components in weight ratio: 25-35g of Phellodendron chinense, 15-25g of Forsythia suspensa, 15-25g of Taraxacum herb, 20-30g of Rhubarb, 15-25g of Scutellaria baicalensis, 25-35g of Sanguisorba officinalis, 25-35g of Sophora flavescens, 15-25g of Lonicera japonica, 15-25g of Platycladus orientalis charcoal, 10-20g of Indigo naturalis and 3-8g of Sodium Sulfate.

[0048] Embodiment 1:

[0049] Take 25g of Phellodendron chinense, 15g of Forsythia suspensa, 15g of Taraxacum mongolicum, 20g of Rhubarb, 15g of Scutellaria baicalensis, 25g of Sanguisorba officinalis, 2g of Sophora flavescens, 15g of Lonicera japonica, 15g of Platycladus orientalis charcoal, 10g of Indigo naturalis, and 3g of Sodium sulfate according to the weight ratio, wash and dry them, put them into medicine bags, soak them with water in a Chinese medicine decoction machine for 15 minutes, extract them under micro-pressure for 35 minutes, divide them into packaging bags with a capacity of 100ml, sterilize them at a high temperature of 100℃ for 25 minutes, and store them at a low temperature below 20℃ and away from light, to complete the preparation of Scutellaria baicalenema solution No. 2.

[0050] Embodiment 2:

[0051] Take 30g of Phellodendron chinense, 20g of Forsythia suspensa, 20g of Taraxacum mongolicum, 25g of Rhubarb, 20g of Scutellaria baicalensis, 30g of Sanguisorba officinalis, 30g of Sophora flavescens, 20g of Lonicera japonica, 20g of Platycladus orientalis charcoal, 15g of Indigo naturalis, and 5g of Sodium sulfate according to the weight ratio, wash and dry them, put them into medicine bags, soak them with water in a Chinese medicine decoction machine for 20 minutes, extract them under micro-pressure for 40 minutes, divide them into packaging bags with a capacity of 100ml, sterilize them at a high temperature of 100℃ for 30 minutes, and store them at a low temperature below 20℃ and away from light, to complete the preparation of Scutellaria baicalenema solution No. 2.

[0052] Embodiment 3:

[0053] Take 35g of Phellodendron chinense, 25g of Forsythia suspensa, 25g of Taraxacum mongolicum, 30g of Rhubarb, 25g of Scutellaria baicalensis, 35g of Sanguisorba officinalis, 35g of Sophora flavescens, 25g of Lonicera japonica, 25g of Platycladus orientalis charcoal, 20g of Indigo naturalis, and 8g of Sodium sulfate according to the weight ratio, wash and dry them, put them into medicine bags, soak them with water in a Chinese medicine decoction machine for 25 minutes, extract them under micro-pressure for 45 minutes, divide them into packaging bags with a capacity of 100ml, sterilize them at a high temperature of 100℃ for 35 minutes, and store them at a low temperature below 20℃ and away from light, to complete the preparation of Scutellaria baicalenema solution No. 2.

[0054] When using:

[0055] [Usage and Dosage] 100-200ml / time, 2 times / day, retention enema.

[0056] [Precautions] Before enema, empty the stool, control the temperature of the liquid at 36℃-37℃, and raise the buttocks after enema. Avoid spicy, greasy, raw and cold food during treatment. This bag can be soaked in boiling water and heated for use. Do not use it if the bag is broken or produces odor.

[0057] The results of some clinical trials of the present invention are compared as follows:

[0058] Experimental content:

[0059] 160 cases of chronic nonspecific ulcerative colitis diagnosed with the disease according to the "Clinical Guiding Principles for Research on New Chinese Medicines" were divided into four groups, namely, the Example 1 drug group, the Example 2 drug group, the Example 3 drug group and the Western medicine control group, each with 40 people.

[0060] After the experiment started, the control group was given one common suppository on the market, and anus treatment every night before going to bed. The Example 1 drug group, the Example 2 drug group and the Example 3 drug group were given the Chinese medicine prescription retention enema of the present invention, one dose per day, decocted in water to obtain 200 ml of juice, and high retention enema every night before going to bed.

[0061] All four groups had one course of treatment of 2 weeks, followed by a 2-day rest period before the second course of treatment. The efficacy was statistically analyzed after two courses of treatment.

[0062] The statistical criteria for efficacy are:

[0063] Markedly effective: clinical symptoms disappear, colonoscopy reveals normal mucosa, medication is discontinued or only maintenance doses are used, and no recurrence occurs after 6 months of observation;

[0064] Effective: Clinical symptoms basically disappeared, and colonoscopy revealed mild mucosal inflammation and partial formation of pseudopolyps;

[0065] Ineffective: No improvement in clinical symptoms, colonoscopy and pathological examination.

[0066] According to the test results in Table 1, it can be seen that the total effective rate of the control group is 70%, while the total effective rates of the drug group in Example 1, the drug group in Example 2 and the drug group in Example 3 are 90%, 95% and 92.5% respectively. It is obvious that the therapeutic effects of the three test groups are significantly better than those of the control group, which shows that the enema solution of the present invention has a better therapeutic effect on chronic nonspecific ulcerative colitis.

[0067] Comparison table of clinical treatment effects of Example 1-3 groups and control group:

[0068] Group Number of cases Significant effect efficient invalid Total Effectiveness Example 1 Drug Group 40 15 21 4 90％ Example 2 Drug Group 40 16 22 2 95％ Example 3 Drug Group 40 14 23 3 92.5％ Control group 40 7 21 12 70％

[0069] Some specific clinical treatment cases:

[0070] Case 1: Zhang XX, female, 52 years old

[0071] On March 19, 2023, the first diagnosis result of the rectal colonoscopy was as follows: the scope was inserted into the cavity to 5m at the end of the ileum, the scope was inserted smoothly, the ileocecal valve was lip-shaped, no obvious abnormality was found in the appendix opening, a small amount of feces was found in the intestinal cavity, and the observation of some mucosa was unsatisfactory. When the scope was withdrawn to 7cm from the anal margin, the mucosa was granular, congested, edematous, and had longitudinal flaky shallow ulcers. The vascular network disappeared, and 2 biopsies were taken. The vascular network of the rest of the colon was clear, the colon bag structure was normal, and no raised lesions or ulcers were found; the examination conclusion: ulcerative colitis (active stage).

[0072] Treatment plan: Use 100 ml of the enema solution described in Example 2, perform enema once a day, and continue the treatment for 1 month.

[0073] On June 29, 2023, the results of the rectoscopy follow-up were: the endoscope was inserted into the ileum to 5 cm at the end, the insertion was smooth, the ileocecal valve was lip-shaped, and there was no obvious abnormality in the opening of the ileum. There was a small amount of feces in the intestinal cavity, and the observation of some mucosa was unsatisfactory. When the endoscope was withdrawn to the sigmoid colon and rectum, rough, congested, scattered flaky erythema could be seen on the mucosa, and the vascular texture was unclear, which was significantly improved compared with the previous film.

[0074] The vascular network of the rest of the colon was clear, the structure of the colon pouch was normal, and no raised lesions or ulcers were found; examination conclusion.

[0075] Ulcerative colitis (in remission).

[0076] Case 2: Yang XX, male, 41 years old

[0077] On February 20, 2024, the first diagnosis result of the rectal colonoscopy was as follows: the scope was inserted into the cavity to 5 cm at the end of the ileum, and the scope was inserted smoothly. The ileocecal valve was lip-shaped, and there was no obvious abnormality in the appendix opening. There was a large amount of feces in the intestinal cavity, which blocked the colonoscope. Repeated flushing was ineffective, and the observation of some mucosa was unsatisfactory. A mucosal congestion and edema with a diameter of about 0.5 cm was seen at the end of the ileum, with a central depression and shallow ulcer formation. Two biopsies were taken. Erosive mucosal congestion, edema, erosion, shallow ulcer formation, and disappearance of the vascular network were seen in the ileocecal region and ascending colon. One biopsy was taken in the ascending colon. When the scope was withdrawn to the sigmoid and rectum, a large amount of white mucus was attached to the intestinal wall, and the mucosa was diffusely congested, edematous, eroded, shallow ulcers formed, and the vascular network disappeared. Two pathological pieces were taken from the sigmoid colon and rectum. The rest of the colon vascular network was clear, the colon bag structure was normal, and no raised lesions or ulcers were seen.

[0078] Examination conclusion: ulcerative colitis (active phase).

[0079] Treatment plan: Use 100 ml of the enema solution described in Example 2, perform enema once a day, and continue the treatment for 1 month.

[0080] On June 11, 2024, the results of the rectal colonoscopy follow-up were as follows: the scope was inserted into the cavity to 5 cm at the end of the ileum, and the scope was inserted smoothly. The ileocecal valve was lip-shaped, and there was no obvious abnormality in the opening of the rotten tail. There was a small amount of feces in the intestinal cavity. The observation of some mucosa was unsatisfactory. A diverticulum-like structure with a diameter of 0.2 cm was seen in the ileocecal part. When the scope was withdrawn to the sigmoid colon and rectum, scattered mucosal spots and sheets of mucosal congestion and edema were seen, and the vascular network was unclear (better than the previous film). The vascular network of the rest of the colon was clear, the colon bag structure was normal, and no raised lesions or ulcers were seen.

[0081] Examination conclusion: ulcerative colitis (recovery stage).

[0082] Case 3: Tie XX, female, 34 years old

[0083] On March 7, 2024, the results of the first proctoscopy were as follows: the endoscope was inserted into the ileocecal region through the cavity, the insertion was smooth, the ileocecal valve was lip-shaped, no obvious abnormalities were found in the appendix opening, there was a small amount of feces in the intestinal cavity, and the observation of some mucosa was unsatisfactory. When the endoscope was withdrawn to the sigmoid colon and rectum, diffuse mucosal congestion, edema, and erosion were seen, shallow ulcers were formed, the vascular network disappeared, the vascular network of the rest of the colon was clear, the structure of the colon pouch was normal, and no raised lesions or ulcers were found.

[0084] Examination conclusion: ulcerative colitis (active phase).

[0085] Treatment plan: Use 100 ml of the enema solution described in Example 3, perform enema once a day, and continue the treatment for 1 month.

[0086] On June 25, 2024, the results of the rectal colonoscopy follow-up were as follows: the endoscope was inserted into the ileum smoothly, the ileocecal valve was lip-shaped, the mucosa was diffusely congested from the appendix opening to the blind end, the vascular texture was blurred, a small amount of feces was in the intestinal cavity, and the observation of some mucosa was unsatisfactory. The mucosa was diffusely congested and edematous 20 to 10 cm from the anus, and the vascular texture was unclear. The anus was congested, edematous, and had punctate bleeding. The vascular network of the rest of the colon was clear, the colon bag structure was normal, and no raised lesions or ulcers were found.

[0087] Examination conclusion: ulcerative colitis (remission period).

[0088] Case 4: Gai X, male, 25 years old

[0089] On August 19, 2023, the results of the first colonoscopy were as follows: Insertion: smooth, cleanliness slightly poor; Delivery site: ileocecal part; Terminal ileum: no abnormalities found; Ileocecal valve: no abnormalities found in morphology and mucosa; Ascending colon: extensive congestion and edema of the mucosa, punctate erosion and bleeding, and blurred vascular texture; Transverse colon: extensive congestion and edema of the mucosa, punctate erosion and bleeding, and blurred vascular texture; Descending colon: extensive congestion and edema of the mucosa, punctate erosion and bleeding, and unclear vascular texture; Sigmoid colon: extensive congestion, edema, erosion, bleeding, and unclear vascular texture of the mucosa; Rectum: extensive congestion, edema, erosion, bleeding, and soft biopsy.

[0090] Examination conclusion: ulcerative colitis (active phase).

[0091] Treatment plan: Use 100 ml of the enema solution described in Example 1, perform enema once a day, and continue the treatment for 1 month.

[0092] On February 12, 2024, the results of the rectoscopy follow-up were: the endoscope was inserted into the ileocecal region smoothly, the ileocecal valve was lip-shaped, no obvious abnormalities were found in the appendix opening, there was a small amount of feces in the intestinal cavity, and the observation of some mucosa was unsatisfactory. Scattered punctate erosions were seen when the endoscope was withdrawn to the descending colon, sigmoid colon, and rectum. The rest of the colon vascular network was clear, the colon pouch structure was normal, and no raised lesions or ulcers were found.

[0093] Examination conclusion: ulcerative colitis (remission period).

[0094] result

[0095] (1) Enema treatment using this enema solution can effectively alleviate the patient's clinical symptoms and physical and chemical indicators;

[0096] (2) No adverse events occurred before and after enema treatment using this enema solution, which shows that this treatment method is safe and reliable and worthy of clinical promotion.

[0097] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. Scutellaria baicalensis enema solution No. 2, characterized by: The invention is prepared from the following raw material drug components in the following weight proportions: 25-35g of Phellodendron chinense, 15-25g of Forsythia suspensa, 15-25g of Taraxacum mongolicum, 20-30g of Rhubarb, 15-25g of Scutellaria baicalensis, 25-35g of Sanguisorba officinalis, 25-35g of Sophora flavescens, 15-25g of Lonicera japonica, 15-25g of Platycladus orientalis charcoal, 10-20g of Indigo naturalis and 3-8g of Sodium Sulfate.

2. The Scutellaria baicalensis enema solution No. 2 according to claim 1, characterized in that: The invention is prepared from the following raw material drug components in the following weight ratio: 25g of Phellodendron amurense, 15g of Forsythia suspensa, 15g of Taraxacum mongolicum, 20g of Rhubarb, 15g of Scutellaria baicalensis, 25g of Sanguisorba officinalis, 2g of Sophora flavescens, 15g of Lonicera japonica, 15g of Platycladus orientalis charcoal, 10g of Indigo naturalis and 3g of Sodium Sulfate.

3. The Scutellaria baicalensis enema solution No. 2 according to claim 1, characterized in that: The invention is prepared from the following raw material drug components in the following weight ratio: 30g of Phellodendron amurense, 20g of Forsythia suspensa, 20g of Taraxacum mongolicum, 25g of Rhubarb, 20g of Scutellaria baicalensis, 30g of Sanguisorba officinalis, 30g of Sophora flavescens, 20g of Lonicera japonica, 20g of Platycladus orientalis charcoal, 15g of Indigo naturalis and 5g of Sodium sulfate.

4. The Scutellaria baicalensis enema solution No. 2 according to claim 1, characterized in that: The invention is prepared from the following raw material drug components in the following weight ratio: 35g of Phellodendron amurense, 25g of Forsythia suspensa, 25g of Taraxacum mongolicum, 30g of Rhubarb, 25g of Scutellaria baicalensis, 35g of Sanguisorba officinalis, 35g of Sophora flavescens, 25g of Lonicera japonica, 25g of Platycladus orientalis charcoal, 20g of Indigo naturalis and 8g of Sodium sulfate.

5. The method for preparing the Scutellaria baicalensis enema solution No. 2 according to any one of claims 1 to 4, characterized in that: The following steps are involved: Step 1: Take the above medicinal materials in corresponding proportions according to the weight ratio, wash and set aside; Step 2: Dry the washed medicinal materials in step 1 using a drying device and put them into medicine bags for decoction; Step 3: Place the medicine bag filled with medicinal materials in step 2 into a Chinese medicine decoction machine, add an appropriate amount of water to soak for 15-25 minutes, and extract under slight pressure for 35-45 minutes; Step 4: Pack the liquid medicine extracted in step 3 into packaging bags and sterilize them at 100° C. for 25-35 minutes to complete the preparation of Scutellaria baicalensis enema solution No.

2.

6. The method for preparing the Scutellaria baicalensis enema solution No. 2 according to claim 5, characterized in that: The capacity of the packaging bag in step 3 is 100 ml.

7. The method for preparing the Scutellaria baicalensis enema solution No. 2 according to claim 5, characterized in that: The liquid medicine prepared in step 4 and packaged in the packaging bag is stored in a low temperature environment below 20° C. and away from light.