Functional composition for dispelling effects of alcohol and protecting liver and preparation method thereof

Abstract

The invention provides a functional composition for alleviating hangover and protecting liver and a preparation method thereof, and belongs to the technical field of hangover alleviating products. Comprising the following raw materials in parts by weight: 10 to 25 parts of silybum marianum, 10 to 25 parts of globe artichoke, 2 to 10 parts of ampelopsis grossedentata leaves, 0.1 to 5 parts of rice bran fatty alkanol, 2 to 10 parts of chamomile, 2 to 10 parts of inositol, 0.1 to 5 parts of alpha-lipoic acid, 0.1 to 5 parts of cysteine, 0.01 to 5 parts of vitamin, 0.01 to 1 part of sodium selenite, 0.5 to 2.5 parts of lubricant, 15 to 40 parts of excipient and 10 to 30 parts of filler. Meanwhile, the invention further provides a preparation method of the composition, and the obtained composition achieves the effects of rapidly dispelling the effects of alcohol and avoiding hangover discomfort.

Description

Technical Field

[0001] The invention relates to the technical field of alcohol sobering products, and in particular to a functional composition for sobering up and protecting the liver and a preparation method thereof. Background Art

[0003] After drinking alcohol, about 90% of the alcohol is metabolized by the liver and then excreted from the body. The liver metabolism pathway is as follows: alcohol is absorbed through the gastrointestinal tract into the blood and reaches the liver, where an enzymatic reaction occurs: alcohol dehydrogenase converts alcohol into acetaldehyde, and acetaldehyde dehydrogenase decomposes acetaldehyde into harmless compounds such as acetic acid. After drinking moderate amounts of alcohol, alcohol can be excreted through liver metabolism and other methods, but if you drink excessively for a long time, the burden on the liver will increase, and the acetaldehyde produced during the decomposition process will continue to damage liver function, resulting in liver damage, hepatitis, fatty liver, alcoholic cirrhosis and other diseases, which are very harmful to the human body.

[0004] The patent with publication number CN114522218B, entitled "A composition for rapid hangover relief and liver protection and its preparation method", discloses that Pueraria root, Bupleurum, Milk thistle, Hovenia dulcis, and Phyllanthus urinaria are crushed and then subjected to enzymatic hydrolysis, water extraction, and alcohol extraction, and then activated Acetobacter and Gluconobacter oxidans are added for aerobic fermentation, the obtained product is mixed with fucoidan sulfate and corn oligopeptide, and activated Lactobacillus paracasei and Lactobacillus rhamnosus are added for anaerobic fermentation, and the product is evenly mixed with ginsenoside rh2, baicalin, and taurine to obtain a composition for rapid hangover relief and liver protection. However, in the above technical scheme, each Chinese medicine is subjected to enzymatic hydrolysis, water extraction, and alcohol extraction, and then subjected to aerobic and anaerobic fermentation, and the preparation method is complicated and cannot solve the problem of hangover discomfort. Summary of the invention

[0005] In view of this, the present invention provides a functional composition for sobering up and protecting the liver and a preparation method thereof, so as to achieve the effects of quickly sobering up and avoiding the discomfort of hangover.

[0006] To achieve the above objectives, the present invention provides a functional composition for sobering up and protecting the liver, comprising the following raw materials: milk thistle, artichoke, Agave sphenanthera leaf, rice bran fatty alkyl alcohol, chamomile, inositol, α-lipoic acid, cysteine, vitamins, sodium selenite, lubricant, excipient and filler.

[0007] Silybin, the active ingredient in milk thistle used in the present invention, has an inhibitory effect on the activity of hepatic stellate cells and reduces their expression, thereby achieving the effects of anti-infection and anti-liver fibrosis. In addition, its strong antioxidant properties can help alleviate oxidative stress, maintain the fluidity of cell membranes, avoid or prevent the loss of soluble cell components such as transaminases, and protect liver cell membranes. Protect liver cells from damage by toxins and support healthy liver detoxification and elimination processes.

[0008] The artichoke used in the present invention promotes liver blood circulation, promotes liver cell regeneration, restores or improves liver function, reduces blood lipid cholesterol, and promotes the discharge of excess lipid substances in the body.

[0009] The rice bran fatty alkanol used in the present invention has the functions of inhibiting liver oxidative metabolic disorder, helping alcohol metabolism, preventing alcoholic liver damage, reducing multiple important liver indexes such as GOT and GPT, and maintaining good normal liver function.

[0010] Optionally, the following raw materials are included in parts by weight: 10-25 parts of milk thistle, 10-25 parts of artichoke, 2-10 parts of Agave sphenanthera leaves, 0.1-5 parts of rice bran fatty alcohol, 2-10 parts of chamomile, 2-10 parts of inositol, 0.1-5 parts of α-lipoic acid, 0.1-5 parts of cysteine, 0.01-5 parts of vitamins, 0.01-1 parts of sodium selenite, 0.5-2.5 parts of lubricant, 15-40 parts of excipient, and 10-30 parts of filler.

[0011] Optionally, the following raw materials are included in parts by weight: 13-20 parts of milk thistle, 13-20 parts of artichoke, 3-8 parts of Agave sphenanthera leaves, 1-3 parts of rice bran fatty alcohols, 3-7 parts of chamomile, 3-7 parts of inositol, 1-4 parts of α-lipoic acid, 1-3 parts of cysteine, 1-3 parts of vitamins, 0.1-0.5 parts of sodium selenite, 0.5-1.5 parts of lubricant, 20-30 parts of excipients, and 15-25 parts of fillers.

[0012] Optionally, the excipient is one or more of sugar alcohol or starch; and the lubricant is magnesium stearate.

[0013] Optionally, the filler is at least one of cellulose and dextrin.

[0014] Optionally, the cellulose is low-substituted hydroxypropyl cellulose and / or cross-linked sodium carboxymethyl cellulose with a high water absorption expansion coefficient; and the dextrin is cyclodextrin.

[0015] The fillers used in the present invention include low-substituted cellulose, cyclodextrin, cross-linked sodium carboxymethyl cellulose, etc., which have large surface area and porosity in their raw material characteristics, good hygroscopicity and water absorption, and a water absorption expansion rate of 500% to 700%. In addition, cyclodextrin accelerates the disintegration effect. The tablet cores made therefrom can quickly disintegrate after contacting the solution in the food digestive system after being ingested into the body, and the particles after disintegration are also relatively small, so they are very conducive to the dissolution and absorption of the effective ingredients.

[0016] In order to achieve the above-mentioned purpose, the present invention also provides a preparation method of a functional composition for sobering up and protecting the liver, comprising: mixing milk thistle, artichoke, α-lipoic acid and part of a filler, adding a binder, purified water or ethanol, granulating and drying to obtain a granular mixture A; preliminarily mixing rice bran fatty alkyl alcohol, cysteine, vitamins and sodium selenite, and then premixing with an equal amount of filler in a gradient manner to obtain a powder mixture B; and mixing an excipient, Agave sphenanthera leaf, chamomile, inositol, a lubricant and the remaining filler with the granular mixture A and the powder mixture B to obtain a composition.

[0017] Optionally, the composition and auxiliary materials can be prepared into tablets, powders, capsules and suspensions.

[0018] Optionally, a coating solution made of hydroxypropyl methylcellulose is added to the tablets for coating.

[0019] Optionally, the coating layer is at least a layer with a strong shielding effect.

[0020] When the present invention uses a layer of coating, it is required to have a strong shielding effect, so as to seal the exchange between the tablet core and the external environment and prolong the preservation of the functional components in the tablet core. When a coating layer is set outside the layer of coating, the coating material is selected according to different requirements, such as color, taste, glossiness, etc., so as to achieve a pleasant appearance and protect the tablet core.

[0021] The above technical solution of the present invention includes at least the following beneficial effects: The present invention uses milk thistle and artichoke to achieve efficient absorption and accelerate the elimination of liver toxins. The DHM (dihydromyricetin) contained in the leaves of Agave sphenanthera triggers the liver to produce more enzymes that promote ethanol decomposition, including alcohol dehydrogenase ADH and acetaldehyde dehydrogenase ALDH, which reduces ethanol-induced liver fatty degeneration and triglyceride accumulation in the liver, weakens ethanol-induced liver enzyme release and the expression of pro-inflammatory cytokines, improves the efficiency of ADH and ALDH, accelerates the elimination of ethanol, reduces lipid accumulation in liver tissue, and inhibits the formation of hepatic M cell collagen fibers. At the same time, α-lipoic acid increases the effect of antioxidant enzymes, and works together with amino acids, chamomile and other ingredients to decompose alcohol, maintain digestive cells, prevent hangovers, and avoid discomfort after hangovers. DETAILED DESCRIPTION

[0022] In order to make the purpose, technical solution and advantages of the embodiment of the present invention clearer, the technical solution of the embodiment of the present invention will be clearly and completely described in combination with the embodiment of the present invention. Obviously, the described embodiment is a part of the embodiment of the present invention, not all the embodiments. Based on the described embodiment of the present invention, all other embodiments obtained by ordinary technicians in this field belong to the scope of protection of the present invention.

[0023] Example 1 Weigh 13 parts of milk thistle, 20 parts of artichoke, 8 parts of Ampelopsis grossedentata leaves, 3 parts of rice bran fatty alkyl alcohols, 3 parts of chamomile, 7 parts of inositol, 1 part of α-lipoic acid, 1 part of cysteine, 1 part of vitamins, 0.5 part of sodium selenite, 0.5 part of magnesium stearate, 30 parts of sugar alcohols, and 15 parts of cellulose for later use.

[0024] 13 parts of milk thistle, 20 parts of artichoke, 1 part of alpha-lipoic acid and 5 parts of cellulose are mixed evenly, water is added, stirred, granulated and then dried to obtain a granular mixture A; 3 parts of rice bran fatty alkyl alcohol, 1 part of cysteine, 1 part of vitamins and 0.5 parts of sodium selenite are preliminarily mixed, and then gradient premixed with 5.5 parts of cellulose to obtain a powder mixture B; 30 parts of sugar alcohol, 8 parts of ampelopsis serrulata leaves, 3 parts of chamomile, 7 parts of inositol, 0.5 parts of magnesium stearate and the remaining 4.5 parts of cellulose are mixed evenly with the granular mixture A and the powder mixture B to obtain a composition, the composition is tableted by using a high-speed rotary tablet press to obtain a complete and smooth tablet core, and a coating liquid made of hydroxypropyl methylcellulose is used for coating to obtain a tablet.

[0025] Example 2 Weigh 20 parts of milk thistle, 13 parts of artichoke, 3 parts of Ampelopsis grossedentata leaves, 1 part of rice bran fatty alkyl alcohols, 7 parts of chamomile, 3 parts of inositol, 4 parts of α-lipoic acid, 3 parts of cysteine, 3 parts of vitamins, 0.1 part of sodium selenite, 1.5 parts of magnesium stearate, 20 parts of sugar alcohols, and 25 parts of dextrin for later use.

[0026] 20 parts of milk thistle, 13 parts of artichoke, 4 parts of alpha-lipoic acid and 10 parts of dextrin are mixed evenly, water is added for stirring, granulation is performed and then drying is performed to obtain a granular mixture A; 1 part of rice bran fatty alkyl alcohol, 3 parts of cysteine, 3 parts of vitamins and 0.1 part of sodium selenite are preliminarily mixed, and then gradient premixed with 7.1 parts of dextrin to obtain a powder mixture B; 20 parts of sugar alcohol, 3 parts of ampelopsis serrulata leaves, 7 parts of chamomile, 3 parts of inositol, 1.5 parts of magnesium stearate and the remaining 7.9 parts of dextrin are mixed evenly with the granular mixture A and the powder mixture B to obtain a composition, the composition is tableted by using a high-speed rotary tablet press to obtain a complete and smooth tablet core, and a coating liquid made of hydroxypropyl methylcellulose is used for coating to obtain a tablet.

[0027] Example 3 Weigh 10 parts of milk thistle, 25 parts of artichoke, 2 parts of Ampelopsis grossedentata leaves, 5 parts of rice bran fatty alkyl alcohols, 10 parts of chamomile, 2 parts of inositol, 0.1 parts of α-lipoic acid, 5 parts of cysteine, 5 parts of vitamins, 0.01 parts of sodium selenite, 0.5 parts of magnesium stearate, 15 parts of sugar alcohols, and 30 parts of dextrin for later use.

[0028] 10 parts of milk thistle, 25 parts of artichoke, 0.1 parts of alpha-lipoic acid and 5 parts of dextrin are mixed evenly, water is added for stirring, granulation is performed, and then drying is performed to obtain a granular mixture A; 5 parts of rice bran fatty alkyl alcohol, 5 parts of cysteine, 5 parts of vitamins and 0.01 parts of sodium selenite are preliminarily mixed, and then gradient premixed with 15.1 parts of dextrin to obtain a powder mixture B; 15 parts of sugar alcohol, 2 parts of ampelopsis serrulata leaves, 10 parts of chamomile, 2 parts of inositol, 0.5 parts of magnesium stearate and the remaining 9.9 parts of dextrin are mixed evenly with the granular mixture A and the powder mixture B to obtain a composition, the composition is tableted by using a high-speed rotary tablet press to obtain a complete and smooth tablet core, and a coating liquid made of hydroxypropyl methylcellulose is used for coating to obtain a tablet.

[0029] Example 4 Weigh 25 parts of milk thistle, 10 parts of artichoke, 10 parts of Ampelopsis grossedentata leaves, 0.1 parts of rice bran fatty alkanols, 2 parts of chamomile, 10 parts of inositol, 5 parts of α-lipoic acid, 0.1 parts of cysteine, 0.01 parts of vitamins, 1 part of sodium selenite, 2.5 parts of magnesium stearate, 40 parts of sugar alcohols, and 10 parts of cellulose for later use.

[0030] 25 parts of milk thistle, 10 parts of artichoke, 5 parts of alpha-lipoic acid and 4 parts of cellulose are mixed evenly, ethanol is added for stirring, granulation is performed and then dried to obtain a granular mixture A; 0.1 part of rice bran fatty alkyl alcohol, 0.1 part of cysteine, 0.01 part of vitamins and 1 part of sodium selenite are preliminarily mixed, and then gradiently premixed with 1.21 parts of cellulose to obtain a powder mixture B; 40 parts of sugar alcohol, 10 parts of ampelopsis serrulata leaves, 2 parts of chamomile, 10 parts of inositol, 2.5 parts of magnesium stearate and the remaining 4.79 parts of cellulose are mixed evenly with the granular mixture A and the powder mixture B to obtain a composition, and the composition is filled into a hard capsule shell to obtain a capsule.

[0031] Example 5 Weigh 17 parts of milk thistle, 17 parts of artichoke, 6 parts of Ampelopsis grossedentata leaves, 2 parts of rice bran fatty alkyl alcohols, 5 parts of chamomile, 5 parts of inositol, 3 parts of α-lipoic acid, 3 parts of cysteine, 2 parts of vitamins, 0.3 parts of sodium selenite, 1 part of magnesium stearate, 25 parts of sugar alcohols, and 20 parts of cellulose for later use.

[0032] 17 parts of milk thistle, 17 parts of artichoke, 3 parts of α-lipoic acid and 5 parts of cellulose are mixed evenly, water is added for stirring, granulation and drying are performed to obtain a granular mixture A; 2 parts of rice bran fatty alkyl alcohol, 3 parts of cysteine, 2 parts of vitamins and 0.3 parts of sodium selenite are preliminarily mixed, and then gradiently premixed with 7.3 parts of cellulose to obtain a powder mixture B; 25 parts of sugar alcohol, 6 parts of ampelopsis serrulata leaves, 5 parts of chamomile, 5 parts of inositol, 1 part of magnesium stearate and the remaining 7.7 parts of cellulose are mixed evenly with the granular mixture A and the powder mixture B to obtain a composition, and the composition is crushed into powder and sieved to obtain a powder.

[0033] Comparative Example 1 Compared with Example 5, the only difference is that the same amount of milk thistle is used instead of artichoke, that is, 34 portions of milk thistle are used. The rest of the raw materials, portions and steps are the same.

[0034] Comparative Example 2 Compared with Example 5, the only difference is that the same amount of artichokes is used instead of milk thistle, that is, 34 portions of artichokes are used. The rest of the raw materials, portions and steps are the same.

[0035] Comparative Example 3 Compared with Example 5, the only difference is that the Ampelopsis grossedentata leaves are not used. The other raw materials, portions and steps are the same.

[0036] Comparative Example 4 Compared with Example 5, the only difference is that α-lipoic acid is not used. The other raw materials, parts and steps are all the same.

[0037] A mouse experiment was conducted on Examples 1 to 5 and Comparative Examples 1 to 4 to detect the alcohol sobering effects.

[0038] Hangover test (1) Determination of the optimal intoxicating dose for mice Eighteen mice of 6-8 weeks old with good life and health index were randomly divided into 3 groups. They were gavaged with 56% ethanol at a dose of 8 mg / kg bw, 10 mg / kg bw, and 12 mg / kg bw, respectively. The time and behavioral response of the mice until they became drunk were observed and recorded. The different stages of drunkenness were judged as follows: sober (normal activities), slightly drunk (excited, slow movements), drunk (whole body shaking), lethargy (quiet, deep sleep), and death, as shown in Table 1.

[0039] Table 1 Determination of the optimal intoxication dose for mice

[0040] As can be seen from Table 1, with the increase of dose, the drunkenness rate and mortality rate of mice also increased. When the dose was 8 mg / kg bw and 10 mg / kg bw, the drunkenness rate of mice reached 100%. The drunk mice shook all over and their righting reflex disappeared. When the dose was further increased, some mice died. Therefore, the optimal drunkenness dose for mice was determined to be 10 mg / kg bw.

[0041] (2) Determination of the latency period of drunkenness and sleep duration in mice Take the compositions prepared in Examples 1 to 5, record them as No. 1, No. 2, No. 3, No. 4, No. 5, respectively, and take the compositions prepared in Comparative Examples 1 to 4, record them as No. 6, No. 7, No. 8, and No. 9, respectively. Take 50 mice with good life and health index of 6-8 weeks, half of which are male and half are female, and randomly divided into 10 groups, namely, the control group, the No. 1 test group, the No. 2 test group, the No. 3 test group, the No. 4 test group, the No. 5 test group, the No. 6 test group, the No. 7 test group, the No. 8 test group, and the No. 9 test group. Fast for 12 hours before the test. The composition of each test group was gavaged at a dose of 60 mg / kg bw, and the control group was given an equal volume of distilled water. After 30 minutes, each group was gavaged with 56% ethanol at a dose of 10 mg / kg bw, and the behavioral characteristics were recorded. The disappearance of righting reflex of mice was used as a sleep indicator. The time of disappearance and recovery of righting reflex of mice were recorded, and the intoxication latency (the time from ethanol administration to disappearance of righting reflex) and sleep maintenance time (the time from disappearance of righting reflex to recovery) were calculated. Table 2 is obtained.

[0042] Table 2 Effects of the composition on the incubation period of drunkenness and sleep maintenance time of mice

[0043] As shown in Table 2, compared with the control group mice, each experimental group can prolong the incubation period of drunkenness and shorten the sleep maintenance time, that is, the experimental groups all have a certain anti-drunkenness effect. However, according to the comparison between the experimental groups 1 to 5 and the experimental groups 6 to 9, it can be seen that the anti-drunkenness effect of the compositions prepared in Examples 1 to 5 of the present invention is significantly higher than that of the comparative examples 1 to 4. And the effect of the compositions prepared in Examples 1 to 5 on preventing hangovers and avoiding the discomfort after hangovers is also significantly higher than that of comparative examples 1 to 4.

[0044] The above are preferred embodiments of the present invention. It should be pointed out that, for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A functional composition for sobering up and protecting the liver, characterized in that: Including the following ingredients: Milk thistle, artichoke, Agave sphenanthera leaf, rice bran fatty alkyl alcohol, chamomile, inositol, α-lipoic acid, cysteine, vitamins, sodium selenite, lubricant, excipient, filler.

2. The functional composition for sobering up and protecting the liver according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 10-25 parts of milk thistle, 10-25 parts of artichoke, 2-10 parts of ampelopsis pilosula leaves, 0.1-5 parts of rice bran fatty alkyl alcohol, 2-10 parts of chamomile, 2-10 parts of inositol, 0.1-5 parts of alpha-lipoic acid, 0.1-5 parts of cysteine, 0.01-5 parts of vitamins, 0.01-1 parts of sodium selenite, 0.5-2.5 parts of lubricant, 15-40 parts of excipient and 10-30 parts of filler.

3. The functional composition for sobering up and protecting the liver according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 13-20 parts of milk thistle, 13-20 parts of artichoke, 3-8 parts of ampelopsis serrulata leaves, 1-3 parts of rice bran fatty alkyl alcohol, 3-7 parts of chamomile, 3-7 parts of inositol, 1-4 parts of alpha-lipoic acid, 1-3 parts of cysteine, 1-3 parts of vitamins, 0.1-0.5 parts of sodium selenite, 0.5-1.5 parts of lubricant, 20-30 parts of excipient and 15-25 parts of filler.

4. The functional composition for sobering up and protecting the liver according to claim 1, characterized in that: The excipient is one or more of sugar alcohol or starch; and the lubricant is magnesium stearate.

5. The functional composition for sobering up and protecting the liver according to claim 1, characterized in that: The filler is at least one of cellulose and dextrin.

6. The functional composition for sobering up and protecting the liver according to claim 5, characterized in that: The cellulose is low-substituted hydroxypropyl cellulose and / or cross-linked sodium carboxymethyl cellulose with a high water absorption expansion coefficient; and the dextrin is cyclodextrin.

7. A method for preparing the functional composition for sobering up and protecting the liver according to any one of claims 1 to 6, characterized in that: The method comprises the following steps: taking milk thistle, artichoke, α-lipoic acid and part of the filler and mixing them evenly, adding a binder, purified water or ethanol, granulating and drying the granular mixture A; taking rice bran fatty alkyl alcohol, cysteine, vitamins and sodium selenite and pre-mixing them preliminarily, and then pre-mixing them with an equal amount of the filler in a gradient manner to obtain a powdery mixture B; and mixing the excipient, Agave sphenanthera leaf, chamomile, inositol, lubricant and the remaining filler evenly with the granular mixture A and the powdery mixture B to obtain a composite material.

8. The method for preparing the functional composition for sobering up and protecting the liver according to claim 7, characterized in that: The composition can be applied to tablets, powders, capsules and suspensions.

9. The method for preparing the functional composition for sobering up and protecting the liver according to claim 8, characterized in that: When preparing tablets, a coating liquid made of hydroxypropyl methylcellulose is added for coating.

10. The method for preparing the functional composition for sobering up and protecting the liver according to claim 9, characterized in that: The coating layer is at least a layer with a strong shielding effect.

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