An experimental device and method for hearing impairment

Abstract

The present invention relates to the technical field of hearing impairment experiment, and particularly relates to a hearing impairment experiment device and an experiment method, which include a noise component. The noise component includes a noise chamber and a loudspeaker. The noise chamber has a noise cavity, and a through hole communicating with the noise cavity is provided on the side wall of the noise chamber. The loudspeaker is located at the top of the noise cavity; a fixing fixture, which is detachably arranged at the through hole of the noise chamber. The present invention adds a noise chamber with a through hole on the side wall, and fixes the experimental animal at the side wall of the noise chamber through the fixing fixture, and allows the head of the experimental animal to extend into the noise cavity of the noise chamber through the through hole. This not only avoids the evasive activities of the experimental animal, but also, except for the head of the experimental animal being outside the noise chamber, can reduce the damage to various internal organs and nervous systems of the experimental animal, thereby ensuring the reliability of the experimental data.

Description

Technical Field

[0001] The present invention relates to the technical field of hearing impairment experiments, and particularly to a hearing impairment experiment device and an experiment method. Background Art

[0002] The mouse hearing impairment model is an important tool for studying the mechanism of hearing loss and developing treatment methods. The following are some common modeling methods: drug induction method, noise exposure method, gene editing method, surgical injury method, and immune injury method.

[0003] Among them, the principle of the noise exposure method is to expose the mice to a high-intensity noise environment, causing mechanical damage and metabolic disorders in the inner ear, resulting in damage to hair cells, auditory nerve dysfunction, etc., and thus causing hearing loss. However, during the experiment, since the mice will move freely and hide in corners to avoid harm, especially when multiple mice are modeled simultaneously, the mice will huddle together to avoid harm. The harm-avoiding behavior of the mice easily blocks the ear canals, weakening the sound entering the ears, resulting in inconsistent hearing impairment degrees for each mouse, and even inconsistent hearing impairments for the left and right ears of the same mouse, thus failing to meet the experimental requirements.

[0004] Meanwhile, with the mice being entirely in the noise chamber, the high-intensity noise is also likely to affect various internal organs and the nervous system of the mice, causing unnecessary interference to the experiment. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to provide a hearing impairment experiment device and an experiment method to ensure the reliability of experimental data and reduce the damage to the internal organs and nervous system of the mice.

[0006] To solve the above technical problem, one technical solution adopted by the present invention is: A hearing impairment experiment device includes a noise component and a fixing fixture. The noise component includes a noise chamber and a loudspeaker. The noise chamber has a noise cavity, and a through hole communicating with the noise cavity is provided on the side wall of the noise chamber. The loudspeaker is located at the top of the noise cavity;

[0007] The fixing fixture is detachably arranged at the through hole of the noise chamber.

[0008] To solve the above technical problem, another technical solution adopted by the present invention is: An experiment method has fresh air and a noise environment.

[0009] Fix the experimental animal and place only the head of the experimental animal in the noise environment.

[0010] The beneficial effects of the present invention are as follows: A noise chamber with through holes on the side wall is added, and the experimental animal is fixed at the side wall of the noise chamber through a fixing jig, and the head of the experimental animal extends into the noise cavity of the noise chamber through the through hole. This not only avoids the harm avoidance activities of the experimental animal, but also reduces the damage to various internal organs and nervous systems of the experimental animal because only the head of the experimental animal is located outside the noise chamber, thereby ensuring the reliability of the experimental data. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] Figure 1 FIG. is an exploded structural schematic diagram of a hearing impairment experimental device proposed by the present invention;

[0012] Figure 2 FIG. is an assembled structural schematic diagram of a noise component, a fixing jig and a base of a hearing impairment experimental device proposed by the present invention;

[0013] Figure 3 FIG. is an exploded structural schematic diagram of a fixing jig of a hearing impairment experimental device proposed by the present invention;

[0014] Figure 4 FIG. is a structural schematic diagram of a fixing jig of a hearing impairment experimental device proposed by the present invention;

[0015] Figure 5 FIG. is a structural schematic diagram of a noise chamber of a hearing impairment experimental device proposed by the present invention;

[0016] Figure 6 is Figure 5 an enlarged view of part A of the noise chamber of a hearing impairment experimental device;

[0017] Figure 7 FIG. is a sectional structural schematic diagram of a base of a hearing impairment experimental device proposed by the present invention;

[0018] Reference numeral description:

[0019] 1. Noise component; 11. Noise chamber; 111. Through hole; 112. Insertion slot; 113. Sound absorption hole; 114. Decibel detector; 12. Speaker;

[0020] 2. Fixing jig; 21. Box body; 211. Exposure hole; 212. Protrusion; 22. Gate; 23. Second magnet;

[0021] 3. First magnet;

[0022] 4. Base; 41. Ventilation channel; 42. Ventilation boss;

[0023] 5. Sound insulation cover; 51. Heat dissipation hole;

[0024] 6. Screw. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0025] To illustrate the technical content, achieved objectives and effects of the present invention in detail, the following is described in conjunction with the embodiments and with reference to the accompanying drawings.

[0026] Please refer to Figure 1 and Figure 2 As shown, a hearing impairment experimental device includes a noise component 1 and a fixing fixture 2. The noise component 1 includes a noise chamber 11 and a speaker 12. The noise chamber 11 has a noise cavity. A through hole 111 communicating with the noise cavity is provided on the side wall of the noise chamber 11. The speaker 12 is located at the top of the noise cavity. The fixing fixture 2 is detachably arranged at the through hole 111 of the noise chamber 11.

[0027] Working principle: A noise chamber 11 with a through hole 111 on its side wall is added. The experimental animal is fixed at the side wall of the noise chamber 11 through the fixing fixture 2, and the head of the experimental animal extends into the noise cavity of the noise chamber 11 through the through hole 111. This not only avoids the evasive activities of the experimental animal, but also reduces the damage to various internal organs and nervous systems of the experimental animal because except for the head, the experimental animal is outside the noise chamber 11, thereby ensuring the reliability of the experimental data.

[0028] It is worth noting that the noise cavity is cylindrical or frustum-shaped. The speaker 12 is located at the central position at the top of the noise cavity to emit sound, and a plurality of through holes 111 are evenly arranged along the contour on the side wall of the noise chamber 11; so that when conducting experiments on multiple experimental animals simultaneously, the noise intensity received by each experimental animal tends to be consistent.

[0029] It is worth noting that in order to improve the effect of the speaker 12 on the inside of the noise chamber 11 and reduce the influence of the speaker 12 on the outside, the speaker 12 can be a directional speaker, or an acoustic director can be provided on the speaker 12.

[0030] Please refer to Figure 3 As shown, in some embodiments, the fixing fixture 2 includes a box body 21 and a gate 22. The box body 21 has a receiving cavity. An exposure hole 211 communicating with the receiving cavity is provided at one end of the box body 21. The gate 22 is movably arranged on the box body 21 to increase or decrease the communication area between the exposure hole 211 and the receiving cavity. The experimental animal is placed into the receiving cavity of the box body 21, and its head extends out from the exposure hole 211, and then the head of the experimental animal is fixed by operating the gate 22 to prevent the experimental animal from retracting its head into the receiving cavity of the box body 21. At the same time, since the body of the experimental animal is far from the noise chamber 11 and is in the receiving cavity of the box body 21, the damage to the internal organs and nervous system of the experimental animal caused by the noise can be reduced as much as possible.

[0031] It should be noted that the volume of the accommodation cavity of the box body 21 is such that the body of the experimental animal can move therein, which can reduce the discomfort of the experimental animal. Of course, the accommodation cavity can also have a groove for collecting the excrement of the experimental animal, which is away from the exposure hole 211, so as to reduce the pollution of the accommodation cavity by the experimental animal's stimulated excretion during the experiment.

[0032] Please refer to Figure 3 As shown, in some embodiments, there is a screw 6, and a convex block 212 is provided on the box body 21. A threaded hole penetrates through the convex block 212, and the screw rod of the screw 6 can pass through the threaded hole and abut against the gate 22. By rotating the screw 6, the gate 22 can be released and fixed.

[0033] Please refer to Figure 2 and Figure 5 As shown, in some embodiments, a plug-in groove 112 for inserting the fixing fixture 2 is provided on the side wall of the noise chamber 11. The fixing fixture 2 can be quickly fixed on the noise chamber 11 through the plug-in groove 112.

[0034] Please refer to Figures 4 to 6 As shown, in some embodiments, a first magnet 3 is provided on the side wall of the plug-in groove 112, and a second magnet 23 that magnetically attracts the first magnet 3 is provided on the fixing fixture 2. Through the magnetic attraction between the first magnet 3 and the second magnet 23, it is not only convenient for the operator to install the fixing fixture 2 on the noise chamber 11, but also can improve the installation reliability of the fixing fixture 2 on the noise chamber 11.

[0035] The first magnet 3 and the second magnet can be magnets or electromagnets.

[0036] It should be noted that there is a pit on the side wall of the plug-in groove 112, the first magnet 3 is located in the pit, and the second magnet 23 on the fixing fixture 2 can extend into the pit to magnetically attract the first magnet 3. Thereby, the installation reliability of the fixing fixture 2 on the noise chamber 11 can be further improved.

[0037] In some embodiments, the noise chamber 11 further has a sound-absorbing cavity communicating with the noise cavity. The sound-absorbing cavity is located below the noise cavity. A sound-absorbing hole 113 communicating with the sound-absorbing cavity is provided on the side wall of the noise chamber 11, and sound-absorbing cotton (not shown in the figure) is provided in the sound-absorbing cavity. Since the speaker 12 emits sound downward from the top of the noise chamber 11, adding a sound-absorbing cavity with sound-absorbing cotton below the noise cavity can weaken the transmission of noise from the noise chamber 11 to the outside. At the same time, the noise after being absorbed by the sound-absorbing cotton is released into an environment with a larger space through the sound-absorbing hole 113. Due to the sudden change in the space area, the medium and low-frequency noise is reflected and interfered, thereby reducing the sound energy of the medium and low-frequency noise.

[0038] Please refer to Figure 1 、 Figure 2and Figure 5 As shown, in some embodiments, a decibel detector 114 is provided on the noise chamber 11. The decibel detector 114 is used to detect the noise intensity in the noise chamber, so as to facilitate the statistics of experimental data.

[0039] Please refer to Figure 7 As shown, in some embodiments, the hearing impairment experimental device further includes a base 4. The noise component 1 is disposed on the base 4, and a ventilation channel 41 communicating with the noise chamber is provided on the base 4. Through the ventilation channel 41, the air fluid in the noise chamber is ensured, and the heat generated by the operation of each component in the base 4 is reduced for heat dissipation.

[0040] It should be noted that a ventilation boss 42 is provided on the base 4. A plurality of ventilation holes communicating with the ventilation channel 41 are uniformly arranged along the contour of the side wall of the ventilation boss 42 to ensure uniform ventilation in the noise chamber 11, and sound-absorbing cotton is arranged at the side wall of the ventilation boss 42 to weaken the intensity of noise transmitted outward from the ventilation channel 41. Of course, in order to improve the ventilation effect, a fan can be provided at the air inlet of the ventilation channel 41.

[0041] Please refer to Figure 1 As shown, in some embodiments, the hearing impairment experimental device further includes a sound insulation cover 5. The noise component 1 is located in the inner cavity of the sound insulation cover 5, and sound-absorbing cotton (not shown in the figure) is provided on the inner wall of the sound insulation cover 5. The sound insulation cover 5 is used to further weaken the transmission of noise from the noise chamber 11 to the outside.

[0042] Please refer to Figure 1 As shown, in some embodiments, a plurality of heat dissipation holes 51 are provided at the top of the sound insulation cover 5. The heat dissipation holes 51 can dissipate the heat generated by the noise component 1 to the outside, especially the heat generated by the operation of the speaker 12.

[0043] An experimental method has a noise environment, fixes the experimental animal, and only places the head of the experimental animal in the noise environment.

[0044] Furthermore, there is an isolation space, and the experimental animal is located in the isolation space.

[0045] As can be seen from the above description, the isolation space is used to weaken the damage to the internal organs and nervous system of the experimental animal caused by the noise released by the noise environment.

[0046] Furthermore, the isolation space allows the body of the experimental animal to move.

[0047] In the mouse hearing loss experiment, for example, for high-intensity short-term exposure, the mouse needs to be in a noise environment of 115 dB to 125 dB; for medium-intensity exposure, the mouse needs to be in an environment of 90 dB to 115 dB.

[0048] Through noise testing on the structure of the hearing loss experimental device of the present invention, specifically, non-electronic components such as the noise chamber 11, the fixing fixture 2, the base 4, and the sound insulation cover 5 are made of pla material (which can be prepared by 3D printing). A full-frequency speaker and a 200W power amplifier are used as the sound source, and 3 cm thick sound-absorbing cotton is pasted on the inner wall of the sound insulation cover 5. When the sound source releases 125 dB of noise, the decibel value at the exposure hole 211 of the box body 21 reaches about 125 dB, and the decibel value in the accommodation cavity of the box body 21 reaches about 110 dB. At a distance of 20 cm outside the hearing loss experimental device, when the sound insulation cover 5 is not set, the decibel value reaches about 102 dB, and when the sound insulation cover 5 is set, the decibel value reaches about 80 dB.

[0049] When the sound source releases 115 dB of noise, the decibel value at the exposure hole 211 of the box body 21 reaches about 108 dB, and the decibel value in the accommodation cavity of the box body 21 reaches about 91 dB. At a distance of 20 cm outside the hearing loss experimental device, when the sound insulation cover 5 is not set, the decibel value reaches about 85 dB, and when the sound insulation cover 5 is set, the decibel value reaches about 70 dB.

[0050] From the test results, it can be seen that the structure of the hearing loss experimental device of the present invention meets the noise requirements of the mouse hearing loss experiment and will not cause great impact on the external environment.

[0051] Furthermore, a fan with a rated voltage of 12V and a rated current of 0.5A is set at the air inlet of the ventilation channel 41, and temperature testing is carried out with the sound source releasing 125 dB of noise in an environment with a room temperature of about 25°C. After the sound source continuously works for two hours, the temperature at the exposure hole 211 of the box body 21 is about 26.8°C, and the temperature in the accommodation cavity of the box body 21 is about 27.1°C. From the test results, it can be seen that the structure of the hearing loss experimental device of the present invention has good heat dissipation and can reduce unnecessary interference caused by temperature to the experiment.

[0052] The above are only the embodiments of the present invention, and do not limit the patent scope of the present invention accordingly. Any equivalent transformation made by using the content of the specification and drawings of the present invention, or directly or indirectly applied in the relevant technical fields, shall be equally included in the patent protection scope of the present invention.

Claims

1. An experimental device for hearing impairment, characterized in that: It includes a noise component and a fixing jig. The noise component includes a noise chamber and a speaker. The noise chamber has a noise cavity. A through hole communicating with the noise cavity is provided on the side wall of the noise chamber. The speaker is located at the top of the noise cavity. The fixing jig is detachably arranged at the through hole of the noise chamber. The fixing jig includes a box body and a gate. The box body has a receiving cavity for placing the body of the experimental animal. An exposure hole communicating with the receiving cavity is provided at one end of the box body. The exposure hole is used to extend the head of the experimental animal out of the receiving cavity. The gate is movably arranged on the box body to increase or decrease the communication area between the exposure hole and the receiving cavity.

2. The hearing impairment experimental device according to claim 1, wherein: A plug-in groove for plugging the fixing jig is provided on the side wall of the noise chamber.

3. The hearing impairment experimental device according to claim 2, characterized in that: A first magnet is provided on the side wall of the plug-in groove, and a second magnet magnetically attracted to the first magnet is arranged on the fixing jig.

4. The hearing impairment experimental device according to claim 1, wherein: The noise chamber further has a sound-absorbing cavity communicating with the noise cavity. The sound-absorbing cavity is located below the noise cavity. A sound-absorbing hole communicating with the sound-absorbing cavity is provided on the side wall of the noise chamber. Sound-absorbing cotton is provided in the sound-absorbing cavity.

5. The hearing impairment experimental device according to claim 1, characterized in that: A decibel detector is provided on the noise chamber.

6. The hearing impairment experimental device according to claim 1, wherein: It further includes a base. The noise component is arranged on the base. A ventilation channel communicating with the noise cavity is provided on the base.

7. The hearing impairment experimental device according to claim 1, wherein: It further includes a sound-insulating cover. The noise component is located in the inner cavity of the sound-insulating cover. Sound-absorbing cotton is provided on the inner wall of the sound-insulating cover.

8. An experimental method based on the hearing impairment experimental device according to any one of claims 1 to 7, characterized in that: There is a noise environment. Fix the experimental animal and only place the head of the experimental animal in the noise environment.

9. The experimental method according to claim 8, characterized in that: There is an isolation space, and the experimental animal is located in the isolation space.

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