Medicinal and edible formula for treating dysmenorrhea

Abstract

The invention relates to the technical field of medicine and food, in particular to a medicine and food homologous formula for treating dysmenorrhea. 3-60 g of poria cocos or an extract; 3-60 g of Hangzhou white peony root or extract; 3-60 g of roasted rhizoma atractylodis macrocephalae or extract; 3-60 g of radix rehmanniae preparata or extract; 3-60 g of angelica sinensis or an extract; 3-60 g of honey-fried licorice root or extract; 3-60 g of ligusticum wallichii or an extract; the medicinal and edible formula for treating dysmenorrhea has the beneficial effects that the medicinal and edible formula for treating dysmenorrhea has the effects of replenishing blood, activating blood, regulating menstruation, relieving pain and the like, can improve dysmenorrhea caused by blood loss, deficiency of qi and blood, congealing cold or internal retention of water-dampness, can help to improve blood circulation of uterus, can promote uterine contraction, can dredge blood stasis in meridians and collaterals, and has a good curative effect on dysmenorrhea. The blood stasis can be discharged out of the body more smoothly, pain caused by the fact that the uterus is blocked by the blood stasis is relieved, and the traditional Chinese medicine composition has obvious improvement and treatment effects on dysmenorrhea symptoms, is widely applied to female groups and can well meet use requirements.

Description

Technical Field

[0001] The invention relates to the technical field of medicine and food, and in particular to a medicine-food formula for treating dysmenorrhea. Background Art

[0002] Dysmenorrhea is one of the most common gynecological symptoms. It refers to pain and distension in the lower abdomen before, during, or after menstruation, accompanied by backache or other discomfort, and the symptoms seriously affect the quality of life. Dysmenorrhea is divided into primary dysmenorrhea and secondary dysmenorrhea. Primary dysmenorrhea refers to dysmenorrhea without organic lesions of the reproductive organs; secondary dysmenorrhea refers to dysmenorrhea caused by organic pelvic diseases, such as endometriosis and adenomyosis.

[0003] The 21st century is a century where people are the focus, people are the focus of health, and health is the focus of diet therapy and disease prevention, because health is the greatest wealth in life. With health, there is a future and hope. Without health, everything is lost. In traditional Chinese culture, the theory of "medicine and food have the same origin" has a long history, and Chinese medicine has always emphasized that "food supplements are worse than medicine supplements."

[0004] However, at present, the existing technology lacks a medicine-food formula that has the effects of nourishing blood and activating blood circulation, regulating menstruation and relieving pain, can effectively improve dysmenorrhea caused by various reasons, and has a significant improvement and therapeutic effect on the symptoms of dysmenorrhea, and is widely applicable to the female group, which cannot well meet the use needs. Therefore, a medicine-food formula that can invigorate qi, strengthen the spleen and eliminate dampness is proposed. Summary of the invention

[0005] In order to overcome the technical defects in the prior art and effectively solve the technical problems in the background technology, the present invention provides the following technical solutions:

[0006] A medicine-food formula for treating dysmenorrhea, comprising the following components in parts by weight: 3-60 grams of ginseng or an extract; 3-60 grams of Poria cocos or an extract; 3-60 grams of white peony root or an extract; 3-60 grams of stir-fried Atractylodes macrocephala or an extract; 3-60 grams of Rehmannia glutinosa or an extract; 3-60 grams of Chinese angelica or an extract; 3-60 grams of roasted liquorice or an extract; 3-60 grams of Chuanxiong or an extract; and 3-60 grams of Leonurus japonicus or an extract.

[0007] As a preferred technical solution of the present invention, it includes the following components in parts by weight: 20 grams of ginseng or its extract; 20 grams of Poria cocos or its extract; 15 grams of white peony root or its extract; 15 grams of stir-fried Atractylodes macrocephala or its extract; 15 grams of Rehmannia glutinosa or its extract; 30 grams of Angelica sinensis or its extract; 20 grams of roasted Licorice root or its extract; 20 grams of Chuanxiong or its extract; and 10 grams of Leonurus japonicus or its extract.

[0008] As a preferred technical solution of the present invention, it includes the following components in parts by weight: 30 grams of ginseng or its extract; 35 grams of Poria cocos or its extract; 40 grams of white peony root or its extract; 35 grams of stir-fried Atractylodes macrocephala or its extract; 30 grams of Rehmannia glutinosa or its extract; 45 grams of Angelica sinensis or its extract; 40 grams of roasted Licorice root or its extract; 30 grams of Chuanxiong or its extract; and 35 grams of Leonurus japonicus or its extract.

[0009] As a preferred technical solution of the present invention, it includes the following components in parts by weight: 50 grams of ginseng or its extract; 50 grams of Poria or its extract; 55 grams of white peony root or its extract; 45 grams of stir-fried Atractylodes macrocephala or its extract; 50 grams of Rehmannia glutinosa or its extract; 60 grams of Angelica sinensis or its extract; 55 grams of roasted Licorice root or its extract; 50 grams of Chuanxiong or its extract; and 45 grams of Leonurus japonicus or its extract.

[0010] A method for preparing a medicine-food formula for treating dysmenorrhea comprises the following steps:

[0011] (1) Take the above-mentioned Chinese medicinal raw materials by weight, wash them, and dry them;

[0012] (2) Place the mixed raw materials in a container, add water (the ratio of medicinal materials to water is 1:5-7) and soak for 3-5 hours;

[0013] (3) First, boil the water over high heat, then simmer over low heat for 60-100 minutes, filter, and obtain the first decoction;

[0014] (4) adding 3-5 times the amount of water to the filter residue, decocting the residue for the second time according to the above decoction method, filtering the residue to obtain a second decoction liquid;

[0015] (5) Combine the two decoctions and concentrate them at 80-90°C to an extract with a relative density of 1.2-1.4;

[0016] (6) Dry the extract, crush it and prepare it into powder.

[0017] Compared with the prior art, the beneficial effects of the present invention are as follows: the medicine-food formula for treating dysmenorrhea has the effects of nourishing blood, activating blood circulation, regulating menstruation and relieving pain, etc., can improve dysmenorrhea caused by blood loss, qi and blood deficiency, cold stagnation or water retention, and can help improve uterine blood circulation, promote uterine contraction, and dredge blood stasis in the meridians so that the blood stasis can be discharged more smoothly from the body, relieve pain caused by blood stasis blocking the uterus, have obvious improvement and therapeutic effects on the symptoms of dysmenorrhea, are widely applicable to the female population, and can well meet the needs of use.

[0018] The medicinal properties and efficacy of the main, secondary, auxiliary and guiding ingredients of the formula of the present invention are analyzed as follows:

[0019] 1. King of medicines

[0020] Angelica: Sweet and spicy, warm in nature, it enters the liver, heart, and spleen meridians. Angelica can be used as the main drug in prescriptions for the treatment of dysmenorrhea. It has the core functions of nourishing blood, activating blood circulation, regulating menstruation and relieving pain. One of the main causes of dysmenorrhea is poor blood circulation or insufficient blood circulation. Angelica can improve dysmenorrhea caused by blood loss or weak blood circulation by nourishing blood. At the same time, its blood circulation function can dredge blood stasis in the meridians and relieve pain caused by blood stasis blocking the uterus (uterus), which is the key to solving the problem of dysmenorrhea.

[0021] 2. Minister medicine

[0022] Chuanxiong: Spicy, warm in nature, enters the liver, gallbladder, and pericardium meridians. Chuanxiong is a blood-qi medicine, and it is used as a ministerial medicine to assist Angelica sinensis. Its blood-activating and qi-promoting effects can enhance the blood-activating power of Angelica sinensis, allowing blood stasis to be discharged more smoothly from the body. For dysmenorrhea, qi and blood stasis is a common pathological factor. Chuanxiong is like a booster, helping Angelica sinensis improve blood circulation in the uterus and relieve pain caused by blood stasis.

[0023] Motherwort: Spicy and bitter, slightly cold in nature, it enters the liver, pericardium, and bladder meridians. Motherwort is also a ministerial drug, and its main function is to activate blood circulation and regulate menstruation. It has an exciting effect on the uterus, can promote uterine contraction, and help discharge blood stasis, especially suitable for blood stasis type dysmenorrhea. In combination with Angelica sinensis and Chuanxiong, it enhances the effect of activating blood circulation and regulating menstruation, and jointly improves symptoms such as irregular menstruation and dysmenorrhea.

[0024] Rehmannia glutinosa: sweet in taste, slightly warm in nature, and enters the liver and kidney meridians. As a ministerial drug, Rehmannia glutinosa can replenish the yin and blood lost due to menstrual blood loss. For dysmenorrhea caused by insufficient qi and blood, Rehmannia glutinosa can fundamentally nourish the blood and provide a material basis for improving dysmenorrhea. In addition, it cooperates with Angelica sinensis to strengthen the blood-tonifying effect, making the qi and blood sufficient, which helps to relieve dysmenorrhea.

[0025] 3. Adjuvant

[0026] White Peony Root: bitter and sour, slightly cold in nature, and enters the liver and spleen meridians. White Peony Root, as an adjuvant, has the effects of nourishing blood, regulating menstruation, softening the liver and relieving pain. In the treatment of dysmenorrhea, on the one hand, it assists drugs such as Angelica sinensis in nourishing blood, and on the other hand, its effect of softening the liver and relieving pain can relieve the spasm of uterine smooth muscle. When dysmenorrhea occurs, uterine smooth muscle spasm is an important cause of pain. White Peony Root can relieve pain by relieving spasm. At the same time, its slightly cold nature can also prevent other warm drugs (such as Chuanxiong, etc.) from helping fire to generate heat.

[0027] Ginseng: Sweet, slightly bitter, slightly warm in nature, and enters the spleen, lung, heart, and kidney meridians. Ginseng is used as an adjuvant to replenish vital energy. For dysmenorrhea caused by weak qi and blood and decreased body function, ginseng can improve the body's ability to resist pain. At the same time, qi can circulate blood, and ginseng replenishes qi to help promote blood circulation, assist other blood-activating drugs to play a role, and prevent qi deficiency caused by excessive blood loss, etc., which helps relieve dysmenorrhea from the side.

[0028] Stir-fried Atractylodes macrocephala: bitter and sweet, warm in nature, and enters the spleen and stomach meridians. Stir-fried Atractylodes macrocephala can strengthen the spleen and replenish qi. The spleen and stomach are the source of qi and blood biochemical transformation. By strengthening the spleen and enhancing the spleen and stomach's transportation and transformation functions, it can provide guarantees for the generation of qi and blood. In the treatment of dysmenorrhea, it can ensure the adequate supply of qi and blood, assist other drugs to play a role, and the warm nature of Atractylodes macrocephala can also help relieve dysmenorrhea caused by cold stagnation.

[0029] Poria: Sweet, light, neutral in nature, enters the heart, lung, spleen, and kidney meridians. Poria promotes diuresis and eliminates dampness, strengthens the spleen, and calms the mind. In prescriptions for dysmenorrhea, the spleen-strengthening effect of Poria can be coordinated with stir-fried Atractylodes macrocephala to enhance the function of the spleen and stomach. Its diuretic and dampness-injecting effect can help regulate the body's water metabolism, and it also has a certain effect on relieving dysmenorrhea caused by internal water retention. At the same time, it can prevent tonic drugs (such as Rehmannia glutinosa, etc.) from being greasy and obstructing the stomach.

[0030] 4. Use medicine

[0031] Licorice root: sweet in taste, neutral in nature, and enters the heart, lung, spleen, and stomach meridians. Licorice root, as a guiding drug, can harmonize various drugs. It enables various drugs in the prescription to cooperate with each other and avoid conflicts between the nature and taste of the drugs. At the same time, licorice root itself has a certain analgesic effect, which can directly relieve the pain symptoms of dysmenorrhea, and its spleen and stomach tonifying function also helps maintain the normal function of the spleen and stomach, ensuring the absorption and efficacy of the drugs. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 is the number of writhing reactions of the mice of the present invention. DETAILED DESCRIPTION

[0033] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0034] Embodiment 1:

[0035] A medicine-food formula for treating dysmenorrhea, comprising the following components in parts by weight: 20 grams of ginseng or an extract; 20 grams of Poria cocos or an extract; 15 grams of white peony root or an extract; 15 grams of stir-fried Atractylodes macrocephala or an extract; 15 grams of Rehmannia glutinosa or an extract; 30 grams of Chinese angelica or an extract; 20 grams of roasted liquorice or an extract; 20 grams of Chuanxiong or an extract; and 10 grams of Leonurus japonicus or an extract.

[0036] A method for preparing a medicine-food formula for treating dysmenorrhea comprises the following steps:

[0037] (1) Take the above-mentioned Chinese medicinal raw materials by weight, wash them, and dry them;

[0038] (2) Place the mixed raw materials in a container, add water (the ratio of medicinal materials to water is 1:5-7) and soak for 3-5 hours;

[0039] (3) First, boil the water over high heat, then simmer over low heat for 60-100 minutes, filter, and obtain the first decoction;

[0040] (4) adding 3-5 times the amount of water to the filter residue, decocting the residue for the second time according to the above decoction method, filtering the residue to obtain a second decoction liquid;

[0041] (5) Combine the two decoctions and concentrate them at 80-90°C to an extract with a relative density of 1.2-1.4;

[0042] (6) Dry the extract, crush it and prepare it into powder.

[0043] Furthermore, in step (6), appropriate auxiliary materials such as starch, dextrin, brown sugar, etc. can be added to prepare a granular oral powder with a good taste.

[0044] Embodiment 2:

[0045] A medicine-food formula for treating dysmenorrhea, comprising the following components in parts by weight: 30 grams of ginseng or an extract; 35 grams of Poria cocos or an extract; 40 grams of white peony root or an extract; 35 grams of stir-fried Atractylodes macrocephala or an extract; 30 grams of Rehmannia glutinosa or an extract; 45 grams of Chinese angelica or an extract; 40 grams of roasted liquorice or an extract; 30 grams of Chuanxiong or an extract; and 35 grams of Leonurus japonicus or an extract.

[0046] The preparation method of this embodiment is carried out with reference to Example 1.

[0047] Embodiment 3:

[0048] A medicine and food formula for treating dysmenorrhea, comprising the following components in parts by weight: 50 grams of ginseng or an extract; 50 grams of Poria cocos or an extract; 55 grams of white peony root or an extract; 45 grams of stir-fried Atractylodes macrocephala or an extract; 50 grams of Rehmannia glutinosa or an extract; 60 grams of Chinese angelica or an extract; 55 grams of roasted liquorice or an extract; 50 grams of Chuanxiong or an extract; and 45 grams of Leonurus japonicus or an extract.

[0049] The preparation method of this embodiment is carried out with reference to Example 1.

[0050] Experimental Example 1

[0051] Thirty healthy SPF BALB / c mice were selected and randomly divided into three groups, each with 10 mice, namely, Example 1 Group, Example 2 Group and Example 3 Group. The mice in each group were subjected to the dysmenorrhea model induced by intraperitoneal injection of oxytocin. The mice showed twisting movements with abdominal contraction, hind limb extension and buttocks lifting. The mice were given intragastric administration at a dose equivalent to 10 g of the crude drug per kilogram of body weight; the number of twisting reactions of the mice within a certain period of time (such as 30 minutes or 1 hour) was recorded (twisting reaction is a typical manifestation of pain in mice, and an effective dysmenorrhea treatment formula can reduce the number of twisting reactions. For example, normal mice that have not been administrated may have 30-50 twisting reactions after intraperitoneal injection of oxytocin to induce the dysmenorrhea model, while the number of twisting reactions of the mice in the administrated group may be reduced to 10-20 times).

[0052] Result analysis: Figure 1 As shown, the number of writhing reactions of mice in Example 1-3 groups was relatively small, far lower than the number of writhing reactions of mice not given the drug after intraperitoneal injection of oxytocin to induce dysmenorrhea model, among which the number of writhing reactions of mice in Example 1 group was the least, followed by Example 2 group and Example 3 group.

[0053] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A medicine-food formula for treating dysmenorrhea, characterized in that: The invention comprises the following components in parts by weight: 3-60g of ginseng or its extract; 3-60g of Poria cocos or its extract; 3-60g of white peony root or its extract; 3-60g of stir-fried Atractylodes macrocephala or its extract; 3-60g of Rehmannia glutinosa or its extract; 3-60g of Chinese angelica root or its extract; 3-60g of roasted licorice root or its extract; 3-60g of Chuanxiong or its extract; and 3-60g of Leonurus japonicus or its extract.

2. The medicine-food formula for treating dysmenorrhea according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 20 grams of ginseng or its extract; 20 grams of Poria cocos or its extract; 15 grams of white peony root or its extract; 15 grams of stir-fried Atractylodes macrocephala or its extract; 15 grams of Rehmannia glutinosa or its extract; 30 grams of Angelica sinensis or its extract; 20 grams of roasted Licorice root or its extract; 20 grams of Chuanxiong or its extract; and 10 grams of Leonurus japonicus or its extract.

3. The medicine-food formula for treating dysmenorrhea according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 30g ginseng or extract; 35g Poria or extract; 40g white peony root or extract; 35g stir-fried Atractylodes macrocephala or extract; 30g Rehmannia glutinosa or extract; 45g Chinese angelica or extract; 40g roasted licorice or extract; 30g Chuanxiong or extract; 35g Leonurus japonicus or extract.

4. The medicine-food formula for treating dysmenorrhea according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 50 grams of ginseng or its extract; 50 grams of Poria cocos or its extract; 55 grams of white peony root or its extract; 45 grams of stir-fried Atractylodes macrocephala or its extract; 50 grams of Rehmannia glutinosa or its extract; 60 grams of Angelica sinensis or its extract; 55 grams of roasted Licorice root or its extract; 50 grams of Chuanxiong or its extract; and 45 grams of Leonurus japonicus or its extract.

5. The method for preparing the medicine-food formula for treating dysmenorrhea according to any one of claims 1 to 4, characterized in that: The steps include: (1) Take the above-mentioned Chinese medicinal raw materials by weight, wash them, and dry them; (2) Place the mixed raw materials in a container, add water (the ratio of medicinal materials to water is 1:5-7) and soak for 3-5 hours; (3) First, boil the water over high heat, then simmer over low heat for 60-100 minutes, filter, and obtain the first decoction; (4) adding 3-5 times the amount of water to the filter residue, decocting the residue for the second time according to the above decoction method, filtering the residue to obtain a second decoction liquid; (5) Combine the two decoctions and concentrate them at 80-90°C to an extract with a relative density of 1.2-1.4; (6) Dry the extract, crush it and prepare it into powder.

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