Composite functional core material and preparation method thereof

Abstract

The invention relates to the technical field of disposable hygienic products, in particular to a composite functional core material with antibacterial, repairing and skin barrier enhancing functions and a preparation method of the composite functional core material. Comprising a probiotic group component, a skin barrier component, an antibacterial component, a repairing component and other components, and the other components comprise starch, cyclodextrin, an emulsifier and a cross-linking agent. The composite functional core material can effectively inhibit bacterium breeding, regulate skin inflammatory response, enhance skin immune defense capability, promote skin repair and maintain a skin barrier function, so that the use safety and comfort of disposable hygienic products are improved.

Description

Technical Field

[0001] The invention relates to the technical field of disposable sanitary products, and in particular to a composite functional core material with antibacterial, repairing and enhancing skin barrier functions and a preparation method thereof. Background Art

[0002] Disposable sanitary products are daily care products for people. However, traditional disposable sanitary products are prone to breed bacteria during use, causing skin infections and other problems. At the same time, long-term use may cause skin allergies, inflammation, etc., and existing disposable sanitary products are insufficient in maintaining the skin barrier function.

[0003] In view of this, the present invention provides a composite functional core material with antibacterial, repairing and enhancing skin barrier functions and a preparation method thereof. Summary of the invention

[0004] The purpose of the present invention is to provide a composite functional core material and a preparation method thereof in view of the deficiencies of the prior art. The composite functional core material can effectively inhibit bacterial growth, regulate skin inflammatory response, enhance skin immune defense, promote skin repair and maintain skin barrier function, thereby improving the safety and comfort of disposable sanitary products.

[0005] In order to solve the above technical problems, the following technical solutions are adopted:

[0006] A composite functional core material comprises the following weight components:

[0007] (a) Probiotic group components:

[0008] Lactococcus lactis subsp. lactis powder: 1-5 parts;

[0009] Lactobacillus casei powder: 1-4 portions;

[0010] Bifidobacterium longum subsp. longum powder: 1-4 parts.

[0011] The probiotics preferably include three species that play an outstanding role in building skin barrier, inhibiting bacteria and inflammation, and repairing damaged skin cells. The three species may be of the same genus or different genus, preferably genus with different effects, and further preferably different genus with different morphologies, such as: Lactococcus lactis subsp. lactis, Lactobacillus casei, and Bifidobacterium longum subsp. longum. Or Bifidobacterium longum subsp. infantis, Lactobacillus rhamnosus, Bacillus subtilis

[0012] Specifically, Lactococcus lactis subspecies lactis has the function of activating immune cells and enhancing the skin's immune defense ability, allowing the skin to respond quickly to invading pathogens.

[0013] Specifically, Lactobacillus casei can regulate the level of local inflammatory factors in the skin, avoid damage to the skin caused by excessive inflammatory response, and effectively improve allergic conditions.

[0014] Specifically, the technical effects of Bifidobacterium longum subspecies longum are to regulate cell signaling pathways, promote cell growth, differentiation and repair, activate cell energy, and promote the metabolism of skin cells.

[0015] (b) Skin barrier components: one or more of the following components;

[0016] Xylitol: 0.1-5 parts;

[0017] Avocado oil: 0.1-8 parts;

[0018] Jojoba oil: 0.1-6 parts;

[0019] Squalane: 0.1-4 parts;

[0020] Oat extract: 0.1-10 parts;

[0021] Purslane extract: 0.1-8 parts.

[0022] Skin barrier components: can be one or more of xylitol, avocado, jojoba oil, squalane, oats, and purslane. Xylitol can promote the synthesis of intercellular lipids, prevent water loss and the entry of harmful substances, and interact with proteins and lipids in the stratum corneum to enhance the structural stability of the stratum corneum. Avocado, jojoba oil, squalane and other ingredients are rich in nutrients and help nourish and protect the skin. Oats and purslane have the effect of soothing the skin and reducing irritation.

[0023] (c) Antibacterial component: one or more of the following components;

[0024] Naringin extract: 0.1-8 parts;

[0025] Honeysuckle extract: 0.1-7 parts;

[0026] Scutellaria baicalensis extract: 0.1-5 parts;

[0027] Lavender extract: 0.1-3 parts;

[0028] Witch hazel extract: 0.1-3 parts;

[0029] Rosemary extract: 0.1-3 parts;

[0030] Chitosan extract: 0.1-10 parts.

[0031] - Antibacterial component: It can be one or more of naringin, honeysuckle, scutellaria, lavender, witch hazel, and rosemary. Naringin can destroy bacterial cell walls and cell membranes, inhibit the activity of bacterial enzymes, and inhibit the production and release of inflammatory mediators. At the same time, its antioxidant effect can remove skin free radicals and reduce oxidative damage. Plant extracts such as honeysuckle, scutellaria, lavender, witch hazel, and rosemary have broad-spectrum antibacterial effects and can effectively inhibit the growth and reproduction of a variety of bacteria and fungi.

[0032] (d) Repair component: one or more of the following components;

[0033] Aloe vera extract: 0.1-10 parts

[0034] Chamomile extract: 0.1-7 parts

[0035] Calendula extract: 0.1-6 parts

[0036] Centella asiatica extract: 0.1-5 parts

[0037] Rose extract: 0.1-4 parts

[0038] Tea polyphenols: 0.1-5 parts.

[0039] Repairing components: can be one or more of aloe vera, chamomile, calendula, centella asiatica, rose, and tea polyphenols. Aloe vera has the effects of moisturizing, soothing and promoting wound healing; chamomile and calendula can reduce skin inflammation and allergic reactions; centella asiatica helps promote skin cell regeneration and repair damaged tissues; rose has the effect of moisturizing the skin and improving skin color; tea polyphenols can activate the signaling pathways related to collagen synthesis, promote the proliferation and activity of fibroblasts, regulate epidermal cell proliferation and keratinocyte differentiation, and thus promote skin self-repair.

[0040] (e) Other components:

[0041] 45-70 parts of starch;

[0042] Cyclodextrin 5-15 parts;

[0043] Emulsifiers;

[0044] Cross-linking agent.

[0045] Furthermore, the probiotic group can be replaced by Bifidobacterium longum subsp. infantis, Lactobacillus rhamnosus, and Bacillus subtilis, wherein the Bifidobacterium longum subsp. infantis, Lactobacillus rhamnosus, and Bacillus subtilis are 1-5 parts, 1-4 parts, and 1-4 parts, respectively.

[0046] Furthermore, the emulsifier is Tween-80, the cross-linking agent is glutaraldehyde, and the concentration of the glutaraldehyde can be 0.5%-2%.

[0047] The present invention proposes another technical solution: a method for preparing a composite functional core material, comprising the following steps:

[0048] S1. Raw material preparation;

[0049] S2. Mixing process: Under a sterile environment, the prepared Lactococcus lactis powder, Lactobacillus casei powder, Bifidobacterium longum powder, refined oil, plant extract and concentrated plant ingredients are added to a mixing device in a predetermined proportion; low-speed stirring is used for pre-mixing to make the components initially evenly dispersed, and then the stirring speed is gradually increased to medium or high speed, and stirring is continued for 30-60 minutes to ensure that the components are fully mixed to form a stable functional mixture;

[0050] S3. Preparation of microcapsule wall material: Mixing starch and cyclodextrin in a predetermined ratio in an appropriate amount of distilled water; controlling the total concentration of starch and cyclodextrin to be between 10% and 30% to obtain a starch-cyclodextrin wall material solution; heating and stirring the starch-cyclodextrin wall material solution to raise the temperature of the starch-cyclodextrin wall material solution to 60-80° C., and controlling the stirring speed to 300-500 rpm to promote gelatinization of starch;

[0051] S4. Emulsification process: the functional mixture and the emulsifier are mixed uniformly according to a ratio of 1: (0.1-0.5) to form an oil phase product; then the oil phase product is slowly added to the starch-cyclodextrin wall material solution prepared above, and emulsified under high-speed stirring, and the high-speed stirring is controlled at 1000-2000rpm; the emulsification time lasts for 10-30 minutes until a stable emulsion is formed, at which time the functional mixture is dispersed into tiny oil droplets, which are wrapped by the starch-cyclodextrin wall material solution;

[0052] S5. Microcapsule formation: adding a preset cross-linking agent to the emulsion, and continuing to stir and react for a period of time; the cross-linking agent forms chemical bonds between starch and cyclodextrin molecules, thereby solidifying the wall material and encapsulating the functional mixture inside the microcapsule, the reaction time is 1-3h, and the temperature is maintained at 40-60°C; after the cross-linking reaction is completed, the solution is cooled to room temperature to form stable microcapsules;

[0053] S6. Separation and drying: The microcapsules are separated from the solution by centrifugation and filtration; finally, the separated microcapsules are vacuum dried at low temperature to remove moisture to obtain a dried final functional microcapsule product;

[0054] S7. Molding process: The above-mentioned functional microcapsule products are transported to the molding equipment. According to the design requirements of disposable sanitary products, a double-layer or multi-layer sheet clamping or fusion process is adopted, and hot melt adhesive fixing, hot pressure bonding fixing, wet or dry fixing process is adopted to fix the functional microcapsules between the sheets or fuse them with the sheets to obtain a composite functional core material.

[0055] Furthermore, the raw material preparation includes the cultivation and processing of probiotic components: the specific process is as follows: Lactococcus lactis, Lactobacillus casei and Bifidobacterium longum are cultivated respectively; in a suitable culture medium, the temperature, pH value and anaerobic environment are strictly controlled to allow the bacteria to multiply in large quantities; after the cultivation is completed, it is concentrated by centrifugation and filtration, and then freeze-drying is used to make it into bacterial powder for easy storage and subsequent use.

[0056] Furthermore, the raw material preparation also includes the preparation of skin barrier components, and the specific process is as follows: for the avocado, jojoba oil, and squalane oil components, firstly refine them to remove impurities and improve the purity; then use physical refining or chemical refining methods to obtain pure oils;

[0057] The oat and purslane plant raw materials are firstly cleaned, dried and crushed, and then a suitable extraction method is adopted to extract the effective components therein; after the extraction is completed, they are concentrated to obtain a concentrated solution or extract for use.

[0058] Furthermore, the raw material preparation also includes extraction of antibacterial components, and the specific process is as follows: naringin, honeysuckle, scutellaria, lavender, witch hazel, rosemary, and chitosan raw materials, select a suitable extraction method according to the characteristics of different plant raw materials, and extract the effective ingredients therein; after extraction, purification treatment is performed to obtain a high-purity plant extract.

[0059] Furthermore, the raw material preparation also includes processing of repair components, and the specific process is as follows: the aloe vera, chamomile, calendula, centella asiatica, and rose plant raw materials are first cleaned and crushed, and then the effective ingredients are extracted by solvent extraction, and the extract is concentrated to obtain an extract.

[0060] Further, in step S6, the centrifugation method controls the speed to 3000-5000 rpm and the centrifugation time to 10-20 minutes.

[0061] Further, in step S7, the sheet material is one or more of non-woven fabric, toilet paper, and dust-free paper.

[0062] The above technical solution has the following beneficial effects:

[0063] 1. Significant antibacterial effect: The synergistic effect of various plant extracts and probiotic components in the antibacterial component can effectively inhibit the growth of bacteria and fungi during the use of disposable sanitary products and reduce the risk of skin infection.

[0064] 2. Regulate skin inflammation: Probiotics such as Lactobacillus casei and Bifidobacterium longum subspecies longum work together with plant extracts with anti-inflammatory effects to regulate the level of local inflammatory factors in the skin, reduce skin inflammatory reactions, and have a good improvement effect on skin allergies and other problems.

[0065] 3. Enhance skin immunity: Lactococcus lactis subspecies lactis activates immune cells, enhances the skin's immune defense capabilities, and improves the skin's resistance to pathogens.

[0066] 4. Repair skin damage: The various plant ingredients in the repair components can promote skin cell regeneration, accelerate wound healing, improve skin health, and reduce friction and irritation damage to the skin caused by disposable sanitary products.

[0067] 5. Maintain skin barrier: Ingredients such as xylitol in the skin barrier components enhance the stability of the stratum corneum structure, prevent water loss and the entry of harmful substances, maintain the moisture balance of the skin, and maintain the normal barrier function of the skin. DETAILED DESCRIPTION

[0068] In order to make the purpose, technical scheme and advantages of the present invention clearer, the present invention is further described in detail below through embodiments. However, it should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the scope of the present invention. In addition, in the following description, the description of known structures and technologies is omitted to avoid unnecessary confusion of the concept of the present invention.

[0069] Example 1

[0070] S1. Prepare materials.

[0071] Probiotic group component: culture and prepare a certain amount of Lactococcus lactis subsp. lactis powder, Lactobacillus casei powder and Bifidobacterium longum subsp. longum powder.

[0072] Skin barrier component: xylitol.

[0073] Antibacterial component: Naringin

[0074] Repairing ingredients: tea polyphenols.

[0075] Wall material components: starch, microcapsules

[0076] Auxiliary ingredients: emulsifier, cross-linking agent

[0077] S2. Preparation process of efficacy mixture.

[0078] The prepared components are mixed according to the following weight ratio: 1.5 parts of Lactococcus lactis subsp. lactis powder, 1.5 parts of Lactobacillus casei powder, 1.5 parts of Bifidobacterium longum subsp. longum powder, 1 part of xylitol, 1 part of naringin extract, and 1 part of tea polyphenols. In a sterile environment, use a high-speed mixer to fully stir and mix for 30-60 minutes to ensure that the components are evenly distributed.

[0079] S3. Preparation of microcapsule wall materials.

[0080] Starch and cyclodextrin are mixed in a proper amount of distilled water at a ratio of 5:1. The total concentration of starch and cyclodextrin is 20%, and a starch-cyclodextrin wall material solution is obtained. That is, in 100g of starch-cyclodextrin wall material solution, the total mass of starch and cyclodextrin can be 20g.

[0081] Heat and stir the starch-cyclodextrin wall material solution to raise its temperature to 60-80°C to promote starch gelatinization. Continuous stirring during this process can fully mix the starch and cyclodextrin to form a uniform wall material solution. The stirring speed can be controlled at 500rpm.

[0082] S4. Emulsification process.

[0083] The functional mixture and the emulsifier are mixed evenly in a ratio of 1:0.3 to form an oil phase product. For example, if there is 10g of the functional mixture, 3g of Tween-80 can be added.

[0084] Then the oil phase product is slowly added to the starch-cyclodextrin wall material solution prepared above, and emulsified under high-speed stirring (2000rpm). The emulsification time can last for 30 minutes until a stable emulsion is formed. At this point, the functional mixture is dispersed into tiny oil droplets and is wrapped by the starch-cyclodextrin wall material solution.

[0085] S5. Microcapsule formation. Add an appropriate amount of crosslinking agent glutaraldehyde to the emulsion at a concentration of 1%, and continue stirring to react for a period of time. The crosslinking agent will form chemical bonds between starch and cyclodextrin molecules, thereby solidifying the wall material and encapsulating the functional mixture inside the microcapsule. The reaction time can be 3 hours and the temperature can be maintained at 50°C.

[0086] After the cross-linking reaction is completed, the solution is cooled to room temperature to stabilize the microcapsule structure.

[0087] S6. Separation and drying.

[0088] The microcapsules are separated from the solution by centrifugation and filtration. Finally, the separated microcapsules are vacuum dried at low temperature (such as 40° C.) to remove moisture and obtain dry functional microcapsule products.

[0089] S7. Molding process.

[0090] The functional microcapsule products are transported to the molding equipment, and the functional microcapsules are fixed between the two layers of non-woven fabrics using a double-layer non-woven fabric clamping process and a hot melt adhesive fixing process, and finally a composite functional core material is obtained. The core after molding needs to be quality inspected, such as appearance inspection, size measurement, component uniformity inspection, etc., to ensure that it meets the quality standards.

[0091] Through the above carefully designed preparation method, it is possible to ensure that the activity and efficacy of each component can be fully exerted, so that the composite core has excellent antibacterial, repair and skin barrier protection properties, providing an innovative and highly functional core component for disposable sanitary products.

[0092] Embodiment 2-8 (multiple embodiments with different parameters can be set as needed to further verify the feasibility and optimization effect of the invention)

[0093] 1. Adjust the proportion of each component or use different raw material sources, pretreatment methods, etc., and repeat the preparation process in Example 1. Specifically as follows: Examples 2-8 are designed based on the basic preparation process of Example 1, respectively, by adjusting the proportion of components, changing the source of raw materials, changing the pretreatment method, etc. Each example comprehensively demonstrates the influence of different parameter settings on the performance of the composite functional core material through clear material preparation, functional mixture preparation, microcapsule wall material preparation, emulsification, microcapsule formation, separation and drying, and molding processing steps, providing rich data support for the optimization and feasibility verification of this application.

[0094] Example 2

[0095] S1. Prepare materials

[0096] - Probiotic component: culture and prepare a certain amount of Lactococcus lactis subsp. lactis powder, Lactobacillus casei powder and Bifidobacterium longum subsp. longum powder.

[0097] -Skin barrier components: avocado oil, oat extract.

[0098] - Antibacterial ingredients: honeysuckle extract, chitosan extract.

[0099] - Repairing ingredients: Aloe vera extract, calendula extract.

[0100] -Wall material components: starch, cyclodextrin.

[0101] - Auxiliary ingredients: emulsifier (Tween-80), cross-linking agent (glutaraldehyde).

[0102] S2. Preparation process of the efficacy mixture: Mix the components according to the following weight ratio: 2 parts of Lactococcus lactis subsp. lactis powder, 2 parts of Lactobacillus casei powder, 2 parts of Bifidobacterium longum subsp. longum powder, 2 parts of avocado oil, 3 parts of oat extract, 2 parts of honeysuckle extract, 3 parts of chitosan extract, 3 parts of aloe extract, and 2 parts of calendula extract. Under a sterile environment, use a high-speed mixer to fully stir and mix for 40 minutes to ensure that the components are evenly distributed.

[0103] S3. Preparation of microcapsule wall material: Starch and cyclodextrin are mixed in a proper amount of distilled water at a ratio of 6:1, so that the total concentration of starch and cyclodextrin is 25%. Heat and stir the solution, raise the temperature to 70°C, and control the stirring speed at 400rpm to promote starch gelatinization.

[0104] S4. Emulsification process: The functional mixture and the emulsifier are mixed evenly in a ratio of 1:0.4 to form an oil phase product. The oil phase product is slowly added to the starch-cyclodextrin wall material solution and emulsified for 25 minutes under high-speed stirring (1800 rpm) until a stable emulsion is formed.

[0105] S5. Microcapsule formation: Add 1.5% glutaraldehyde crosslinking agent to the emulsion, continue stirring and reacting for 2.5 hours, and keep the temperature at 55° C. After the crosslinking reaction is completed, cool to room temperature to stabilize the microcapsule structure.

[0106] S6. Separation and drying: The microcapsules were separated by centrifugation (4000 rpm, 15 minutes) and filtration, and vacuum dried at low temperature (35° C.) to obtain dry functional microcapsule products.

[0107] S7. Molding: The functional microcapsule product is transported to the molding equipment, and the multi-layer dust-free paper sheet fusion process is adopted. The functional microcapsules are fixed in the sheet by hot pressing and bonding, and finally a composite functional core material is obtained. After molding, quality inspection is carried out to ensure that it meets the quality standards.

[0108] Example 3

[0109] S1. Prepare materials

[0110] - Probiotic group component: culture and prepare Bifidobacterium longum subsp. infantis powder, Lactobacillus rhamnosus powder, and Bacillus subtilis powder (replacing the original probiotic group component).

[0111] -Skin barrier components: xylitol, squalane, purslane extract.

[0112] - Antibacterial ingredients: Scutellaria baicalensis extract, lavender extract.

[0113] -Repairing ingredients: Chamomile extract, Centella asiatica extract, tea polyphenols.

[0114] -Wall material components: starch, cyclodextrin.

[0115] - Auxiliary ingredients: emulsifier (Tween-80), cross-linking agent (glutaraldehyde).

[0116] S2. Preparation process of the efficacy mixture: Mix by weight: 3 parts of Bifidobacterium longum infantis subsp. powder, 2 parts of Lactobacillus rhamnosus powder, 2 parts of Bacillus subtilis powder, 1.5 parts of xylitol, 1.5 parts of squalane, 2 parts of purslane extract, 1.5 parts of scutellaria extract, 1.5 parts of lavender extract, 2 parts of chamomile extract, 1.5 parts of Centella asiatica extract, and 1.5 parts of tea polyphenols. Stir and mix for 50 minutes under a sterile environment.

[0117] S3. Preparation of microcapsule wall material: Starch and cyclodextrin were mixed in distilled water at a ratio of 4:1, with a total concentration of 15%. Heat and stir to 65°C, with a stirring speed of 350 rpm to promote starch gelatinization.

[0118] S4. Emulsification process: The functional mixture and the emulsifier are mixed at a ratio of 1:0.2 to form an oil phase product, the wall material solution is slowly added, and emulsification is performed at a high speed stirring of 1500 rpm for 20 minutes to form a stable emulsion.

[0119] S5. Microcapsule formation: Add 0.8% glutaraldehyde crosslinking agent, stir and react for 2 hours, and maintain the temperature at 45° C. After the reaction, cool to room temperature.

[0120] S6. Separation and drying: The microcapsules were separated by filtration by centrifugation (3500 rpm, 12 minutes) and dried in vacuum at low temperature (30°C).

[0121] S7. Molding process: adopt double-layer non-woven fabric and toilet paper composite sheet clamping process, use wet method to fix functional microcapsules to obtain composite functional core material, and test the quality after molding.

[0122] Example 4

[0123] S1. Prepare materials

[0124] - Probiotic group ingredients: Lactococcus lactis subsp. lactis powder, Lactobacillus casei powder, Bifidobacterium longum subsp. longum powder.

[0125] -Skin barrier components: jojoba oil, oat extract.

[0126] - Antibacterial ingredients: witch hazel extract, rosemary extract, chitosan extract.

[0127] - Repairing ingredients: rose extract, aloe vera extract.

[0128] -Wall material components: starch, cyclodextrin.

[0129] - Auxiliary ingredients: emulsifier (Tween-80), cross-linking agent (glutaraldehyde).

[0130] S2. Preparation process of the efficacy mixture: The weight ratio of each component is: 1 part of Lactococcus lactis subsp. lactis powder, 1 part of Lactobacillus casei powder, 1 part of Bifidobacterium longum subsp. longum powder, 1 part of jojoba oil, 4 parts of oat extract, 1 part of witch hazel extract, 1 part of rosemary extract, 4 parts of chitosan extract, 1 part of rose extract, and 4 parts of aloe extract. Stir and mix under sterile environment for 35 minutes.

[0131] S3. Preparation of microcapsule wall material: Starch and cyclodextrin were mixed at a ratio of 5:1, with a total concentration of 20%, and heated to 75°C with a stirring speed of 450 rpm to gelatinize the starch.

[0132] S4. Emulsification process: The functional mixture and the emulsifier are mixed at a ratio of 1:0.35 to form an oil phase product, and the wall material solution is added and emulsified for 15 minutes under stirring at 1600 rpm.

[0133] S5. Microcapsule formation: Add 1.2% glutaraldehyde, stir and react for 1.5 hours, keep the temperature at 50°C, and cool after the reaction.

[0134] S6. Separation and drying: The microcapsules were separated by filtration by centrifugation (4500 rpm, 18 minutes) and dried in vacuum at low temperature (40°C).

[0135] S7. Molding process: Use multi-layer sheet fusion technology and hot melt adhesive to fix the functional microcapsules in the non-woven fabric and dust-free paper composite sheet, and check the quality after molding.

[0136] Example 5

[0137] S1. Prepare materials

[0138] - Probiotic group ingredients: Bifidobacterium longum subsp. infantis powder, Lactobacillus rhamnosus powder, Bacillus subtilis powder.

[0139] -Skin barrier components: xylitol, avocado oil, purslane extract.

[0140] - Antibacterial ingredients: naringin extract, honeysuckle extract, and scutellaria baicalensis extract.

[0141] -Repairing ingredients: chamomile extract, calendula extract, tea polyphenols.

[0142] -Wall material components: starch, cyclodextrin.

[0143] - Auxiliary ingredients: emulsifier (Tween-80), cross-linking agent (glutaraldehyde).

[0144] S2. Preparation process of the efficacy mixture: Mix by weight: 4 parts of Bifidobacterium longum infantis subsp. powder, 3 parts of Lactobacillus rhamnosus powder, 3 parts of Bacillus subtilis powder, 2 parts of xylitol, 3 parts of avocado oil, 3 parts of purslane extract, 3 parts of naringin extract, 3 parts of honeysuckle extract, 2 parts of scutellaria extract, 3 parts of chamomile extract, 3 parts of calendula extract, and 2 parts of tea polyphenols. Stir and mix in a sterile environment for 60 minutes.

[0145] S3. Preparation of microcapsule wall material: Starch and cyclodextrin were mixed at a ratio of 7:1, with a total concentration of 28%, heated to 80°C, and stirred at a speed of 500 rpm to complete starch gelatinization.

[0146] S4. Emulsification process: The functional mixture and the emulsifier are mixed at a ratio of 1:0.45 to form an oil phase product, and the wall material solution is added and emulsified for 30 minutes under stirring at 2000 rpm.

[0147] S5. Microcapsule formation: Add 1.8% glutaraldehyde, stir and react for 3 hours, maintain the temperature at 60°C, and cool after the reaction.

[0148] S6. Separation and drying: The microcapsules were separated by filtration by centrifugation (5000 rpm, 20 minutes) and dried in vacuum at low temperature (45°C).

[0149] S7. Molding process: Use double-layer toilet paper sheet clamping technology, use hot pressing to fix the functional microcapsules, make a composite functional core material, and test the quality after molding.

[0150] Example 6

[0151] S1. Prepare materials

[0152] - Probiotic group ingredients: Lactococcus lactis subsp. lactis powder, Lactobacillus casei powder, Bifidobacterium longum subsp. longum powder.

[0153] -Skin barrier components: squalane, oat extract, purslane extract.

[0154] - Antibacterial ingredients: lavender extract, witch hazel extract, chitosan extract.

[0155] - Repairing ingredients: Aloe vera extract, Centella asiatica extract, rose extract.

[0156] -Wall material components: starch, cyclodextrin.

[0157] - Auxiliary ingredients: emulsifier (Tween-80), cross-linking agent (glutaraldehyde).

[0158] S2. Preparation process of the efficacy mixture: The weight ratio of each component is: 3 parts of Lactococcus lactis subsp. lactis powder, 2 parts of Lactobacillus casei powder, 2 parts of Bifidobacterium longum subsp. longum powder, 1 part of squalane, 5 parts of oat extract, 2 parts of purslane extract, 1 part of lavender extract, 1 part of witch hazel extract, 3 parts of chitosan extract, 4 parts of aloe extract, 2 parts of Centella asiatica extract, and 1 part of rose extract. Stir and mix in a sterile environment for 45 minutes.

[0159] S3. Preparation of microcapsule wall material: Starch and cyclodextrin were mixed at a ratio of 5:1, with a total concentration of 22%, and heated to 68°C with a stirring speed of 380 rpm to gelatinize the starch.

[0160] S4. Emulsification process: The functional mixture and the emulsifier were mixed at a ratio of 1:0.3 to form an oil phase product, and the wall material solution was added and emulsified for 22 minutes under stirring at 1700 rpm.

[0161] S5. Microcapsule formation: Add 1.4% glutaraldehyde, stir and react for 2 hours, keep the temperature at 52°C, and cool after the reaction.

[0162] S6. Separation and drying: The microcapsules were separated by filtration by centrifugation (4200 rpm, 16 minutes) and dried under vacuum at low temperature (38°C).

[0163] S7. Molding process: Use a multi-layer sheet clamping fusion process to fix the functional microcapsules in non-woven fabrics, toilet paper, and dust-free paper composite sheets by dry method, and inspect the quality after molding.

[0164] Example 7

[0165] S1. Prepare materials

[0166] - Probiotic group ingredients: Bifidobacterium longum subsp. infantis powder, Lactobacillus rhamnosus powder, Bacillus subtilis powder.

[0167] -Skin barrier components: xylitol, jojoba oil, squalane.

[0168] - Antibacterial ingredients: naringin extract, honeysuckle extract, rosemary extract.

[0169] -Repairing ingredients: chamomile extract, calendula extract, tea polyphenols.

[0170] -Wall material components: starch, cyclodextrin.

[0171] - Auxiliary ingredients: emulsifier (Tween-80), cross-linking agent (glutaraldehyde).

[0172] S2. Preparation process of the efficacy mixture: Mix by weight: 2 parts of Bifidobacterium longum infantis subsp. powder, 1 part of Lactobacillus rhamnosus powder, 1 part of Bacillus subtilis powder, 1 part of xylitol, 2 parts of jojoba oil, 1 part of squalane, 2 parts of naringin extract, 2 parts of honeysuckle extract, 1 part of rosemary extract, 2 parts of chamomile extract, 1 part of calendula extract, and 1 part of tea polyphenols. Stir and mix in a sterile environment for 30 minutes.

[0173] S3. Preparation of microcapsule wall material: Starch and cyclodextrin were mixed in a ratio of 4:1, with a total concentration of 18%, heated to 62°C, and stirred at a speed of 320 rpm to achieve starch gelatinization.

[0174] S4. Emulsification process: The functional mixture and the emulsifier are mixed at a ratio of 1:0.25 to form an oil phase product, and the wall material solution is added and emulsified for 18 minutes under stirring at 1300 rpm.

[0175] S5. Microcapsule formation: Add 1% glutaraldehyde, stir and react for 1.8 hours, maintain the temperature at 48°C, and cool after the reaction.

[0176] S6. Separation and drying: The microcapsules were separated by filtration by centrifugation (3800 rpm, 14 minutes) and dried under vacuum at low temperature (32°C).

[0177] S7. Molding process: Use double-layer non-woven sheet clamping technology, use hot melt adhesive to fix the functional microcapsules to make composite functional core materials, and test the quality after molding.

[0178] Example 8

[0179] S1. Prepare materials

[0180] - Probiotic group ingredients: Lactococcus lactis subsp. lactis powder, Lactobacillus casei powder, Bifidobacterium longum subsp. longum powder.

[0181] -Skin barrier components: avocado oil, oat extract, purslane extract.

[0182] - Antibacterial ingredients: Scutellaria baicalensis extract, Hamamelis virginiana extract, chitosan extract.

[0183] - Repairing ingredients: Aloe vera extract, Centella asiatica extract, rose extract, tea polyphenols.

[0184] -Wall material components: starch, cyclodextrin.

[0185] - Auxiliary ingredients: emulsifier (Tween-80), cross-linking agent (glutaraldehyde).

[0186] S2. Preparation process of efficacy mixture: The weight proportion of each component is: 4 parts of Lactococcus lactis subsp. lactis powder, 3 parts of Lactobacillus casei powder, 3 parts of Bifidobacterium longum subsp. longum powder, 4 parts of avocado oil, 6 parts of oat extract, 4 parts of purslane extract, 3 parts of scutellaria extract, 2 parts of witch hazel extract, 5 parts of chitosan extract, 5 parts of aloe extract, 3 parts of Centella asiatica extract, 2 parts of rose extract, and 2 parts of tea polyphenols. Stir and mix in a sterile environment for 55 minutes.

[0187] S3. Preparation of microcapsule wall material: Starch and cyclodextrin were mixed in a ratio of 6:1, with a total concentration of 26%, heated to 78°C, and stirred at a speed of 480 rpm to promote starch gelatinization.

[0188] S4. Emulsification process: The functional mixture and the emulsifier are mixed at a ratio of 1:0.4 to form an oil phase product, and the wall material solution is added and emulsified for 28 minutes under stirring at 1900 rpm.

[0189] S5. Microcapsule formation: Add 1.6% glutaraldehyde, stir and react for 2.8 hours, keep the temperature at 58°C, and cool after the reaction.

[0190] S6. Separation and drying: The microcapsules were separated by filtration by centrifugation (4800 rpm, 19 minutes) and dried under vacuum at low temperature (42°C).

[0191] S7. Molding process: Use a multi-layer sheet fusion process, combining hot pressing bonding and wet fixation to fix the functional microcapsules in the non-woven fabric and dust-free paper composite sheet, and inspect the quality after molding.

[0192] The prepared composite core is subjected to performance tests, including antibacterial performance tests, skin irritation tests, inflammatory factor level tests, etc.

[0193] The antibacterial performance test implementation steps are as follows:

[0194] -Select test strains: Staphylococcus aureus, Escherichia coli, and Candida albicans were selected according to different standards and application scenarios.

[0195] -Preparation of inoculum: inoculate the test strain into the culture medium and dilute to an appropriate concentration as the inoculum.

[0196] -Sample preparation: The composite functional core material is surface sterilized, cut into appropriate shapes and sizes according to the test method, and pre-treated.

[0197] -Inoculation of samples: Apply the inoculum evenly on the surface of the sample and incubate it at a specific temperature and humidity for a certain period of time.

[0198] -Observation results: After the culture is completed, check the bacterial growth on the surface of the sample.

[0199] -Data analysis: Calculate the antibacterial rate of the sample based on the observed results and compare it with the standard sample to draw the test conclusion.

[0200] -Implementation data: The antibacterial composite cores of disposable sanitary products prepared in Examples 1-8 have an inhibition rate of more than 90% against common pathogens such as Escherichia coli, Staphylococcus aureus, and Candida albicans. There are 15 composite functional core materials in each group of examples, and Staphylococcus aureus and Escherichia coli are used in each group of five, and the average inhibition rate is taken according to the above steps. The experimental results are shown in Table 1 below:

[0201] Table 1

[0202]

[0203]

[0204] -Experimental results: It shows that the composite core has a good antibacterial effect, and with the increase of the content of probiotics and antibacterial components, the inhibition rate tends to further increase.

[0205] Skin irritation test:

[0206] -Implementation steps (taking mouse experiment as an example):

[0207] - Experimental design: clarify the purpose of the test, determine the number of samples required, and set up an experimental group (treated with the composite functional core material or its extract) and a control group (treated with saline or other non-irritating substances).

[0208] -Preparation of experimental materials: Prepare the core material samples and their extracts to be tested, as well as the physiological saline solution required for the control group.

[0209] -Animal model selection: Usually mice with healthy and undamaged skin are selected.

[0210] - Implementation of the experiment: The core material sample or extract is brought into contact with the mouse skin according to the prescribed method, and the skin reaction is observed within the prescribed time (such as 1 hour, 24 hours, 48 ​​hours, 72 hours after application, etc.).

[0211] - Observation index evaluation: A standardized scoring system was used to score the observed skin erythema, edema and other reactions to quantify the severity of the irritation reaction.

[0212] -Data analysis: Conduct statistical analysis on the experimental results and compare the differences between the experimental group and the control group.

[0213] -Implementation data: The composite cores of all examples did not cause obvious skin erythema, edema and other irritation reactions. Five composite functional core materials were taken from each group of examples, and each group of composite functional core materials was used to act on the skin of five mice. The experimental results are shown in Table 2 below:

[0214] Table 2

[0215]

[0216]

[0217] -Experimental results: It shows that it has good safety to the skin.

[0218] The steps for detecting inflammatory factor levels are as follows:

[0219] -Sample collection: obtaining relevant tissue or body fluid samples after using the composite functional core material.

[0220] -Select the detection method: such as enzyme-linked immunosorbent assay, etc.

[0221] -Perform detection: Determine the expression level of inflammatory factors according to the operating procedures of the selected method.

[0222] -Data analysis: Analyze and compare the test results.

[0223] -Implementation data: In a simulated skin inflammation model, after using the composite core, the expression level of inflammatory factor interleukin-6 (IL-6) was reduced to 5pg / mL, and the expression level of tumor necrosis factor-α (TNF-α) was reduced to 6pg / mL. The experimental results are shown in Table 3 below:

[0224] Table 3

[0225]

[0226]

[0227] - Experimental results: It has been proven to have the effect of regulating skin inflammation, and the synergistic effect of probiotics and plant extracts with anti-inflammatory effects is better.

[0228] Experimental data and result analysis

[0229] 1. The antibacterial performance test results show that the antibacterial composite cores of disposable sanitary products prepared in Examples 1-8 have an inhibition rate of more than 90% against common pathogens such as Escherichia coli, Staphylococcus aureus, and Candida albicans, indicating that they have good antibacterial effects, and with the increase in the content of probiotics and antibacterial components, the inhibition rate tends to further increase.

[0230] 2. In the skin irritation test, the composite cores of all embodiments did not cause obvious irritation reactions such as skin erythema and edema, indicating that they have good safety to the skin.

[0231] 3. The detection of inflammatory factor levels found that in the simulated skin inflammation model, after using the composite core, the expression levels of inflammatory factors such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were significantly reduced, proving that it has the effect of regulating skin inflammation, and the synergistic effect of probiotics and plant extracts with anti-inflammatory effects is better.

[0232] It can be seen from the above examples and experimental data that the antibacterial composite core of disposable sanitary products and the preparation method thereof of the present invention are practical, can achieve the expected functional effects of antibacterial, skin repair, inflammation regulation and skin barrier maintenance, and have broad application prospects.

[0233] Specifically: The composite functional core material of the present invention has a significant antibacterial effect. According to experimental detection, the inhibition rate of common pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, and Candida albicans reached more than 90%. With the increase of the content of probiotic group components (such as Lactococcus lactis subspecies powder, Lactobacillus casei powder, etc.) and antibacterial components (such as naringin extract, honeysuckle extract, etc.), the inhibition rate is on the rise. In terms of regulating skin inflammation, probiotics such as Lactobacillus casei and Bifidobacterium longum subspecies long act synergistically with plant extracts with anti-inflammatory effects, which can effectively regulate the level of inflammatory factors in the local skin. In the simulated skin inflammation model experiment, after using this composite core, the expression level of inflammatory factor interleukin-6 (IL-6) was reduced to 5pg / mL, and the expression level of tumor necrosis factor-α (TNF-α) was reduced to 6pg / mL, which significantly reduced the skin inflammatory reaction and had a good improvement effect on problems such as skin allergies. In terms of enhancing skin immunity, Lactococcus lactis can activate immune cells, enhance the skin's immune defense capabilities, and improve the skin's resistance to pathogens. In terms of repairing skin damage, the various plant ingredients in the repair component, such as aloe extract and chamomile extract, can promote skin cell regeneration and accelerate wound healing. Experimental observations have shown that the time to repair skin damage is significantly shortened after using disposable sanitary products containing this composite core. In terms of maintaining the skin barrier, ingredients such as xylitol in the skin barrier component can enhance the stability of the stratum corneum structure and prevent water loss and the entry of harmful substances. After using this composite core, the moisture content of the skin is significantly improved, and the transepidermal water loss rate is significantly reduced to 8g / (m 2 h), effectively maintain the skin's moisture balance and normal barrier function.

[0234] The above are only specific embodiments of the present invention, but the technical features of the present invention are not limited thereto. Any simple changes, equivalent replacements or modifications made based on the present invention to solve basically the same technical problems and achieve basically the same technical effects are all included in the protection scope of the present invention.

Claims

1. A composite functional core material, characterized in that: It consists of the following components by weight: (a) Probiotic group components: Lactococcus lactis subsp. lactis powder: 1-5 parts; Lactobacillus casei powder: 1-4 portions; Bifidobacterium longum subsp. longum powder: 1-4 parts; (b) Skin barrier components: one or more of the following components; Xylitol: 0.1-5 parts; Avocado oil: 0.1-8 parts; Jojoba oil: 0.1-6 parts; Squalane: 0.1-4 parts; Oat extract: 0.1-10 parts; Purslane extract: 0.1-8 parts; (c) Antibacterial component: one or more of the following components; Naringin extract: 0.1-8 parts; Honeysuckle extract: 0.1-7 parts; Scutellaria baicalensis extract: 0.1-5 parts; Lavender extract: 0.1-3 parts; Witch hazel extract: 0.1-3 parts; Rosemary extract: 0.1-3 parts; Chitosan extract: 0.1-10 parts; (d) Repair component: one or more of the following components; Aloe vera extract: 0.1-10 parts Chamomile extract: 0.1-7 parts Calendula extract: 0.1-6 parts Centella asiatica extract: 0.1-5 parts Rose extract: 0.1-4 parts Tea polyphenols: 0.1-5 parts; (e) Other components: 45-70 parts of starch; Cyclodextrin 5-15 parts; Emulsifiers; Cross-linking agent.

2. A composite functional core material according to claim 1, characterized in that: The probiotic group can be replaced by Bifidobacterium longum subsp. infantis, Lactobacillus rhamnosus, and Bacillus subtilis, wherein the Bifidobacterium longum subsp. infantis, Lactobacillus rhamnosus, and Bacillus subtilis are 1-5 parts, 1-4 parts, and 1-4 parts, respectively.

3. A composite functional core material according to claim 1, characterized in that: The emulsifier is Tween-80, the cross-linking agent is glutaraldehyde, and the concentration of the glutaraldehyde can be 0.5%-2%.

4. A method for preparing a composite functional core material according to claim 1 or 3, characterized in that The following steps are involved: S1. Raw material preparation; S2. Mixing process: Under a sterile environment, the prepared Lactococcus lactis powder, Lactobacillus casei powder, Bifidobacterium longum powder, refined oil, plant extract and concentrated plant ingredients are added to a mixing device in a predetermined proportion; low-speed stirring is used for pre-mixing to make the components initially evenly dispersed, and then the stirring speed is gradually increased to medium or high speed, and stirring is continued for 30-60 minutes to ensure that the components are fully mixed to form a stable functional mixture; S3. Preparation of microcapsule wall material: Mixing starch and cyclodextrin in a predetermined ratio in an appropriate amount of distilled water; controlling the total concentration of starch and cyclodextrin to be between 10% and 30% to obtain a starch-cyclodextrin wall material solution; heating and stirring the starch-cyclodextrin wall material solution to raise the temperature of the starch-cyclodextrin wall material solution to 60-80° C., and controlling the stirring speed to 300-500 rpm to promote gelatinization of starch; S4. Emulsification process: the functional mixture and the emulsifier are mixed uniformly according to a ratio of 1: (0.1-0.5) to form an oil phase product; then the oil phase product is slowly added to the starch-cyclodextrin wall material solution prepared above, and emulsified under high-speed stirring, and the high-speed stirring is controlled at 1000-2000rpm; the emulsification time lasts for 10-30 minutes until a stable emulsion is formed, at which time the functional mixture is dispersed into tiny oil droplets, which are wrapped by the starch-cyclodextrin wall material solution; S5. Microcapsule formation: adding a preset cross-linking agent to the emulsion, and continuing to stir and react for a period of time; the cross-linking agent forms chemical bonds between starch and cyclodextrin molecules, thereby solidifying the wall material and encapsulating the functional mixture inside the microcapsule, the reaction time is 1-3h, and the temperature is maintained at 40-60°C; after the cross-linking reaction is completed, the solution is cooled to room temperature to form stable microcapsules; S6. Separation and drying: The microcapsules are separated from the solution by centrifugation and filtration; finally, the separated microcapsules are vacuum dried at low temperature to remove moisture to obtain a dried final functional microcapsule product; S7. Molding process: The above-mentioned functional microcapsule products are transported to the molding equipment. According to the design requirements of disposable sanitary products, a double-layer or multi-layer sheet clamping or fusion process is adopted, and hot melt adhesive fixing, hot pressure bonding fixing, wet or dry fixing process is adopted to fix the functional microcapsules between the sheets or fuse them with the sheets to obtain a composite functional core material.

5. The method for preparing a composite functional core material according to claim 4, characterized in that: The raw material preparation includes culturing and processing of probiotic groups: the specific process is as follows: culturing Lactococcus lactis subspecies lactis, Lactobacillus casei and Bifidobacterium longum subspecies longum respectively; in a suitable culture medium, strictly controlling the temperature, pH value and anaerobic environment, so that the bacteria can multiply in large quantities; After the cultivation is completed, it is concentrated by centrifugation and filtration, and then freeze-dried to make it into bacterial powder for easy storage and subsequent use.

6. The method for preparing a composite functional core material according to claim 4, characterized in that: The raw material preparation also includes the preparation of skin barrier components, and the specific process is as follows: for the avocado, jojoba oil, and squalane oil components, firstly refine them to remove impurities and improve the purity; then use physical refining or chemical refining methods to obtain pure oils; The oat and purslane plant raw materials are firstly cleaned, dried and crushed, and then a suitable extraction method is adopted to extract the effective components therein; after the extraction is completed, they are concentrated to obtain a concentrated solution or extract for use.

7. The method for preparing a composite functional core material according to claim 4, characterized in that: The raw material preparation also includes extraction of antibacterial components, and the specific process is as follows: naringin, honeysuckle, scutellaria, lavender, witch hazel, rosemary, and chitosan raw materials, select appropriate extraction methods according to the characteristics of different plant raw materials, and extract the effective components therein; after extraction, purification treatment is performed to obtain high-purity plant extracts.

8. The method for preparing a composite functional core material according to claim 4, characterized in that: The raw material preparation also includes processing of repair components, and the specific process is as follows: the aloe vera, chamomile, calendula, centella asiatica, and rose plant raw materials are first cleaned and crushed, and then the effective ingredients are extracted by solvent extraction, and the extract is concentrated to obtain an extract.

9. The method for preparing a composite functional core material according to claim 4, characterized in that: In step S6, the centrifugation method controls the speed to 3000-5000 rpm and the centrifugation time to 10-20 minutes.

10. The method for preparing a composite functional core material according to claim 4, characterized in that: In step S7, the sheet material is one or more of non-woven fabric, toilet paper, and dust-free paper.

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