Liquid dispensing device

Abstract

The invention provides liquid sub-packaging equipment which comprises a machine shell, and a heat preservation bin used for containing a container to be sub-packaged and conducting heat preservation on the container to be sub-packaged and a sub-packaging bin used for containing a plurality of sub-packaging bags and conducting heat preservation on the sub-packaging bags are arranged in the machine shell at intervals. The temperature control mechanism comprises a first temperature control assembly which is installed in the heat preservation bin and used for adjusting the temperature in the heat preservation bin. The sub-packaging mechanism is mounted in the sub-packaging bin and used for sub-packaging the liquid in the to-be-sub-packaged container into sub-packaging bags; the liquid path mechanism is installed on the machine shell, and the liquid path mechanism is used for sub-packaging the liquid in the container to be sub-packaged into the sub-packaging bags through the sub-packaging mechanism. According to the liquid split charging device, the liquid split charging quality is improved while the liquid split charging speed is increased, and then the liquid split charging efficiency is improved.

Description

Technical Field

[0001] The invention belongs to the technical field of biomedicine, and in particular relates to a liquid dispensing device. Background Art

[0002] Cell preparation packaging technology is an important part of the field of biomedical technology and is crucial to cell therapy and pharmaceutical preparation. If the requirements for stable and high-precision packaging cannot be met, it will affect the therapeutic effect of the cell preparation and delay the patient's treatment. In the prior art, the volume of the liquid during packaging is usually measured by manually starting and stopping the peristaltic pump, weighing, and manually recording. The above method has a slow packaging speed and cannot quickly package a large dose of cell preparation products into a packaging bag in a short time. In addition, due to the slow packaging speed during the packaging process, the above method may damage the integrity and activity of the cell preparation due to temperature changes, thereby reducing the packaging quality. Summary of the invention

[0003] The invention provides a liquid packaging device to solve the problems of slow packaging speed and low packaging quality of liquid packaging devices in the prior art.

[0004] In view of the above technical problems, an embodiment of the present invention provides a liquid packaging device, comprising:

[0005] A casing, wherein a heat preservation chamber for accommodating containers to be packaged and for keeping the containers to be packaged warm, and a packaging chamber for accommodating a plurality of packaging bags are separately arranged in the casing;

[0006] A temperature control mechanism, comprising a first temperature control component installed in the heat preservation bin and used to adjust the temperature in the heat preservation bin;

[0007] A sub-packaging mechanism is installed in the sub-packaging bin, and the sub-packaging mechanism is used to pack the liquid in the container to be packed into the sub-packaging bag; and

[0008] A liquid path mechanism is installed on the housing, and is used to dispense the liquid in the container to be dispensed into the dispensing bag through the dispensing mechanism.

[0009] Optionally, the temperature control mechanism further comprises a second temperature control component installed in the sub-packaging bin and used for adjusting the temperature in the sub-packaging bin; and / or

[0010] The housing also includes a temperature control channel connected between the heat preservation bin and the sub-packaging bin; the temperature control mechanism also includes a temperature transmission component installed in the temperature control channel and used to control the heat exchange between the heat preservation bin and the sub-packaging bin.

[0011] Optionally, the temperature control mechanism further includes heat-insulating cotton wrapped on the inner wall of the heat-insulating bin, and a heat-insulating plate installed on the bin door of the heat-insulating bin; a heat-insulating space is formed between the heat-insulating plate and the heat-insulating cotton for heat-insulating the containers to be packaged contained in the heat-insulating bin; and / or

[0012] The temperature control mechanism also includes a temperature sensor disposed in the heat preservation chamber and used for detecting the temperature in the heat preservation chamber.

[0013] Optionally, the liquid circuit mechanism includes a quantitative component for detecting the real-time flow rate of liquid flowing from the container to be filled into the filling mechanism; the quantitative component includes a quantitative tube, and a first bubble sensor and a second bubble sensor respectively arranged at both ends of the quantitative tube; the quantitative tube, the first bubble sensor and the second bubble sensor are all installed on the casing.

[0014] Optionally, the liquid circuit mechanism includes a driving component for driving the liquid in the container to be filled to flow into the filling mechanism; the driving component includes a first driving pump for driving the liquid in the container to be filled to flow into the filling mechanism, a first switch valve for controlling the on-off of the pipeline between the container to be filled and the filling mechanism, and a third bubble sensor for real-time monitoring the flow state of the liquid between the container to be filled and the filling mechanism; the first driving pump, the first switch valve and the third bubble sensor are all installed on the casing.

[0015] Optionally, the liquid filling equipment also includes a mixing mechanism installed in the insulation bin; the mixing mechanism includes a mounting plate and a mixing component; the container to be filled is installed on the mounting plate, and the mixing component is installed on the mounting plate and is used to mix the liquid in the container to be filled.

[0016] Optionally, the mixing component includes a linear motion component mounted on the mounting plate, and a mixing plate connected to the linear motion component and arranged opposite to the container to be dispensed; the mixing plate, driven by the linear motion component, beats or squeezes the container to be dispensed to mix the liquid in the container to be dispensed.

[0017] Optionally, a guide hole is provided on the mounting plate; the linear motion assembly includes a driving wheel, a driven wheel, a motor connected to the driving wheel and used to drive the driving wheel to rotate, a transmission belt sleeved on the driving wheel and the driven wheel, a connecting block connecting the transmission belt, and a guide shaft connected to the connecting block; the end of the guide shaft away from the connecting block passes through the guide hole to be connected to the mixing plate.

[0018] Optionally, the linear motion assembly further comprises a linear bearing sleeved in the guide hole and used for guiding; the guide shaft is slidably connected to the linear bearing; and / or

[0019] The guide shaft includes a first guide shaft and a second guide shaft; one end of the mixing plate is rotatably connected to the first guide shaft, and the other end of the mixing plate is detachably connected to the second guide shaft.

[0020] Optionally, the subpackaging mechanism includes a subpackaging switch valve which is arranged at the entrance of each of the subpackaging bags in a one-to-one correspondence and is used to control the opening and closing of the entrance of the subpackaging bag.

[0021] The present invention uses a liquid path mechanism to distribute the liquid in the container to be distributed into multiple distribution bags through a distribution mechanism, thereby realizing rapid distribution of the liquid, thereby improving the speed of liquid distribution. The present invention also separates the heat preservation chamber and the distribution chamber in the casing, controls the temperature in the heat preservation chamber through a temperature control mechanism, and the distribution chamber can protect the distribution bags and also play a certain heat preservation role, thereby controlling the temperature of the cell preparation within the preset temperature requirement range, avoiding the destruction of the integrity and activity of the cell preparation due to temperature discomfort, and improving the quality of liquid distribution. The present invention improves the liquid distribution quality while improving the liquid distribution speed, thereby improving the efficiency of liquid distribution. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] The present invention is further described below in conjunction with the accompanying drawings and embodiments.

[0023] Figure 1 It is a structural schematic diagram of a liquid packaging device provided in one embodiment of the present invention.

[0024] Figure 2 It is a structural schematic diagram of a temperature control mechanism provided in one embodiment of the present invention.

[0025] Figure 3 It is a structural schematic diagram of a liquid path mechanism provided in one embodiment of the present invention.

[0026] Figure 4 It is a schematic structural diagram of a mixing mechanism provided in one embodiment of the present invention.

[0027] Figure 5 It is a structural schematic diagram of a mixing mechanism provided in yet another embodiment of the present invention.

[0028] The reference numerals in the specification are as follows:

[0029] 100, housing; 110, heat preservation chamber; 111, container to be sub-packed; 120, sub-packaging chamber; 121, sub-packaging bag; 200, temperature control mechanism; 210, first temperature control component; 211, first temperature adjustment component; 2111, compressor; 2112, evaporator; 212, first heat exchange component; 2121, metal pipe; 2122, metal sheet; 220, heat insulation cotton; 230, heat insulation board; 240, temperature sensor; 300, sub-packaging mechanism; 310, sub-packaging bag; 320, sub-packaging switch valve; 400, liquid path mechanism; 410, quantitative component; 411, quantitative tube; 412, first bubble sensor; 413, second bubble sensor; 420, drive assembly; 421, first drive pump; 422, first switch valve; 423, third bubble sensor; 424, second drive pump; 425, second switch valve; 500, mixing mechanism; 510, mounting plate; 520, mixing assembly; 521, linear motion assembly; 5211, driving wheel; 5212, driven wheel; 5213, motor; 5214, transmission belt; 5215, connecting block; 5216, guide shaft; 5217, linear bearing; 5218, first guide shaft; 5219, second guide shaft; 522, mixing plate; 600, sample container. DETAILED DESCRIPTION

[0030] In order to make the technical problems, technical solutions and beneficial effects solved by the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0031] It should be understood that the directions or positional relationships indicated by terms such as "upper", "lower", "left", "right", "front", "back", and "middle" are based on the directions or positional relationships shown in the accompanying drawings and are only for the convenience of describing the present invention and simplifying the description. They do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore should not be understood as a limitation of the present invention.

[0032] like Figure 1 and Figure 2 As shown, an embodiment of the present invention provides a liquid packaging device, comprising:

[0033] The housing 100 is provided with a heat preservation chamber 110 for accommodating a container 111 to be dispensed and for keeping the container 111 to be dispensed warm, and a dispensing chamber 120 for accommodating a plurality of dispensing bags 310; in this embodiment, Figure 1As shown, a container 111 to be filled with liquid is installed in the heat preservation chamber 110 on the liquid filling device, and a plurality of filling bags 310 are installed in the filling chamber 120. At the same time, the liquid in the container 111 to be filled can be filled only after a consumable tube group for transmitting fluid (including gas and liquid) is installed on the liquid filling device. In this embodiment, after the filling operation is completed, the next round of filling operation can be carried out by replacing the consumable tube group, the container 111 to be filled, and the filling bag 310, or by directly replacing the filling bag 310 (for example, cutting off the inlet of the filling bag 310 by heat sealing, and then heat-sealing the replaced filling bag 310 to the inlet through a sterile pipe connection machine), thereby improving the filling efficiency. Specifically, the container to be packed 111 can be connected to the multiple packing bags 310 in the packing mechanism 300 through the first transmission pipeline in the consumable tube group. After the container to be packed 111 is installed in the insulation warehouse 110, the multiple packing bags 310 are installed in the packing warehouse 120 and the first transmission pipeline is installed in the liquid circuit mechanism 400, the liquid in the container to be packed 111 can be driven by the liquid circuit mechanism 400 to be packed through the packing mechanism 300 into the multiple packing bags 310 of the packing mechanism 300.

[0034] The temperature control mechanism 200 includes a first temperature control component 210 installed in the insulation chamber 110 and used to adjust the temperature in the insulation chamber 110; it can be understood that the liquid filling equipment is generally used for filling cell preparations, so the liquid in the container 111 to be filled is generally a cell preparation. In order to avoid destroying the integrity and activity of the cell preparation, the cell preparation needs to be stored within the first preset temperature requirement range. The first temperature control component 210 may include a first temperature regulating component 211 and a first heat exchange component 212 connected to the first temperature regulating component 211, wherein the first temperature regulating component 211 is used to regulate its own temperature, and the first heat exchange component 212 is used to exchange heat in the heat preservation bin 110, thereby regulating the temperature in the heat preservation bin 110, and further controlling the temperature of the liquid in the container 111 to be dispensed, so that it meets the first preset temperature requirement range; the first temperature control component 210 may also only include the first temperature regulating component 211, wherein the first temperature regulating component 211 directly exchanges heat in the heat preservation bin 110, thereby regulating the temperature in the heat preservation bin 110, and further controlling the temperature of the liquid in the container 111 to be dispensed, so that it meets the first preset temperature requirement range. The first temperature regulating component 211 may perform temperature regulation by means of compressor refrigeration or semiconductor refrigeration. In one embodiment, the first temperature regulating component 211 performs temperature regulation by means of compressor refrigeration, so that the temperature can be adjusted more quickly. Figure 2As shown, the first temperature regulating element 211 may include components such as a compressor 2111 and an evaporator 2112. The specific refrigeration method may refer to the refrigeration method of air conditioning, etc., and will not be repeated here. The first heat exchange element 212 may include heat-conducting elements such as metal tubes 2121 and / or metal sheets 2122. The first heat exchange element 212 may exchange heat in a contact or non-contact manner. In one embodiment, the first heat exchange element 212 exchanges heat with the liquid in the container to be dispensed 111 by directly contacting the container to be dispensed 111, so that the temperature of the liquid in the container to be dispensed 111 can be adjusted more efficiently.

[0035] The sub-packaging mechanism 300 is installed in the sub-packaging chamber 120, and is used to pack the liquid in the to-be-packed container 111 into the sub-packaging bag 310. The sub-packaging chamber 120 can protect the sub-packaging bag 310, and the sub-packaging chamber 120 can also play a certain role in keeping the cell preparation in the sub-packaging bag 310 warm.

[0036] The liquid path mechanism 400 is installed on the housing 100 , and the liquid path mechanism 400 is used to transfer the liquid in the container 111 to be dispensed into the dispensing bag 310 through the dispensing mechanism 300 .

[0037] The present invention distributes the liquid in the container 111 to be distributed into multiple distribution bags 310 through the distribution mechanism 300 through the liquid path mechanism 400, thereby realizing rapid distribution of the liquid, thereby improving the speed of liquid distribution. The present invention also controls the temperature in the insulation warehouse 110 through the temperature control mechanism 200 by separately setting the insulation warehouse 110 and the distribution warehouse 120 in the housing 100, and the distribution warehouse 120 can protect the distribution bag 310 and also play a certain insulation role, thereby controlling the temperature of the cell preparation within the preset temperature requirement range (including the above-mentioned first preset temperature requirement range and the second preset temperature requirement range mentioned later), avoiding the destruction of the integrity and activity of the cell preparation due to temperature discomfort, and improving the quality of liquid distribution. The present invention improves the liquid distribution quality while improving the liquid distribution speed, thereby improving the efficiency of liquid distribution.

[0038] In one embodiment, the temperature control mechanism 200 also includes a second temperature control component (not shown) installed in the sub-packaging bin 120 and used to adjust the temperature in the sub-packaging bin 120. In this embodiment, the temperature of the sub-packaging bag 310 in the sub-packaging bin 120 can be adjusted by installing the second temperature control component in the sub-packaging bin 120, thereby controlling the temperature of the liquid in the sub-packaging bag 310 to meet the second preset temperature requirement range. It can be understood that the second preset temperature requirement range and the first preset temperature range can be the same or different. The first temperature control component 210 and the second temperature control component can respectively adjust the temperature in the insulation bin 110 and the sub-packaging bin 120, so that the temperature in the insulation bin 110 and the sub-packaging bin 120 meets the first preset temperature requirement range and the second preset temperature requirement range respectively. The second temperature control component may include a second temperature regulating member and a second heat exchange member connected to the second temperature regulating member, the second temperature regulating member is used to adjust its own temperature, and the second heat exchange member is used to exchange heat in the sub-packaging bin 120, so as to maintain the temperature in the sub-packaging bin 120, and then maintain the temperature of the liquid in the sub-packaging bag 310; the second temperature control component may also only include a second temperature regulating member, the second temperature regulating member directly exchanges heat in the sub-packaging bin 120, so as to maintain the temperature in the sub-packaging bin 120, and then control the temperature of the liquid in the sub-packaging bag 310. The second temperature regulating member can adjust the temperature by means of compressor refrigeration or semiconductor refrigeration. In one embodiment, the second temperature regulating member adjusts the temperature by means of semiconductor refrigeration, so as to save costs while achieving temperature maintenance. In one embodiment, the second temperature regulating member exchanges heat with the liquid in the sub-packaging bag 310 by directly contacting the sub-packaging bag 310, so as to more efficiently maintain the temperature of the liquid in the sub-packaging bag 310.

[0039] In one embodiment, the housing 100 further includes a temperature control channel (not shown) connected between the heat preservation bin 110 and the sub-packaging bin 120; the temperature control mechanism 200 further includes a temperature transmission component (not shown) installed in the temperature control channel and used to control the heat exchange between the heat preservation bin 110 and the sub-packaging bin 120. In this embodiment, the sub-packaging bag 310 in the sub-packaging bin 120 can be kept warm by the temperature transmission component installed in the temperature control channel. The temperature control channel may include an air duct connected between the heat preservation bin 110 and the sub-packaging bin 120, and the temperature transmission component may include a fan disposed in the air duct, etc., and then, the fan may drive the cold air in the heat preservation bin 110 to enter the sub-packaging bin 120, so that the sub-packaging bin 120 meets the second preset temperature requirement range corresponding thereto. By controlling the air volume of the fan or the on-off of the air duct, the amount of cold air in the heat preservation chamber 110 entering the sub-packaging chamber 120 can also be controlled, so that the temperature in the heat preservation chamber 110 and the sub-packaging chamber 120 respectively meets the first preset temperature requirement range and the second preset temperature requirement range. The temperature control channel can also include a channel connecting the heat preservation chamber 110 and the sub-packaging chamber 120, and the temperature transmission component can include a heat conduction pipe arranged in the channel, and then the heat conduction pipe can perform heat exchange between the heat preservation chamber 110 and the sub-packaging chamber 120, so that the sub-packaging chamber 120 meets the second preset temperature requirement range corresponding thereto. By controlling the heat conduction amount of the heat conduction pipe (such as the flow rate of the refrigerant in the heat conduction pipe, etc.) or on-off, the amount of cold air in the heat preservation chamber 110 entering the sub-packaging chamber 120 can also be controlled, so that the temperature in the heat preservation chamber 110 and the sub-packaging chamber 120 respectively meets the first preset temperature requirement range and the second preset temperature requirement range.

[0040] In one embodiment of the present invention, while installing the second temperature control component in the filling bin 120, the temperature of the filling bag 310 in the filling bin 120 can be adjusted by the temperature transmission component installed in the temperature control channel, thereby controlling the temperature of the liquid in the filling bag 310 to meet the second preset temperature requirement range. The specific settings can be referred to the description in the above embodiment and will not be repeated here.

[0041] like Figure 2As shown, in one embodiment, the temperature control mechanism 200 further includes heat insulating cotton 220 coated on the inner wall of the heat preservation bin 110, and a heat insulating plate 230 installed on the door of the heat preservation bin 110; a heat insulating space for heat preservation of the container 111 to be dispensed contained in the heat preservation bin 110 is formed between the heat insulating plate 230 and the heat insulating cotton 220. It can be understood that the heat preservation bin 110 includes a door, and the door is provided with a heat insulating plate 230, and a heat insulating space for heat preservation of the container 111 to be dispensed contained in the heat preservation bin 110 is formed between the heat insulating plate 230 and the heat insulating cotton 220. The heat insulating cotton 220 can be arranged on the inner wall partially or completely coated with the heat preservation bin 110. The heat insulation cotton 220 and the heat insulation board 230 can block the heat preservation bin 110 from exchanging heat with the outside world, prevent energy from being dissipated outward, and help maintain the temperature of the liquid in the to-be-packed container 111 to cool down, thereby improving the temperature control efficiency and reducing energy consumption. Furthermore, the bin door and the heat insulation board 230 can be made of a transparent material, so as to facilitate observation of the mixing state of the to-be-packed container 111.

[0042] In one embodiment, the liquid dispensing device further includes a heat dissipation component (not shown) disposed on the housing 100 and used to dissipate heat from the temperature control mechanism 200. The heat dissipation component includes a heat dissipation channel disposed on the housing 100, through which the temperature control mechanism 200 can exchange heat with the outside world; the heat dissipation component also includes a fan disposed in the heat dissipation channel and used to discharge the heat generated by the temperature control mechanism 200, and the fan can accelerate the heat exchange between the temperature control mechanism 200 and the outside world. It can be understood that the temperature control mechanism 200 will generate heat while cooling, and the heat dissipation component can transfer the above heat from the inside of the liquid dispensing device in time, thereby ensuring the rapid cooling effect of the temperature control mechanism 200.

[0043] In one embodiment, the bottom of the heat preservation bin 110 is provided with a drainage groove (not shown) to prevent condensed water or water accumulation caused by leakage of the container 111 to be dispensed. The heat preservation bin 110 is provided with a silicone seal strip at a position corresponding to the bin door, so as to seal the installation gap of the bin door on the heat preservation bin 110 through the silicone seal strip. The bin door is also provided with a glass fiber pad, so that the first heat exchange element 212 and the insulation board 230 are isolated from each other by the glass fiber pad to avoid direct contact between the two, thereby further preventing the energy in the heat preservation bin 110 from being dissipated outward.

[0044] like Figure 2As shown, in one embodiment, the temperature control mechanism 200 further includes a temperature sensor 240 disposed in the heat preservation chamber 110 and used to detect the temperature in the heat preservation chamber 110. It can be understood that the temperature sensor 240 is connected to the temperature control mechanism 200 and is used to transmit a temperature data set to the temperature control mechanism 200. Among them, the temperature sensor 240 includes at least one first temperature sensor 240 disposed in the heat preservation chamber 110 and a second temperature sensor 240 disposed on the first temperature control component 210; the real-time temperature includes a first real-time temperature measured by any one of the first temperature sensors 240 and a second real-time temperature measured by the second temperature sensor 240 disposed on the first temperature control component 210; in this embodiment, the temperature data set may include only the first real-time temperature measured by the first temperature sensor 240 of the heat preservation chamber 110, or only the second real-time temperature measured by the second temperature sensor 240; or may include both the second real-time temperature and one or more first real-time temperatures, as long as all real-time temperatures in the temperature data set meet the first preset temperature requirement range. Among them, the first preset temperature requirement range in the above embodiment of the present invention can mean that each real-time temperature in the temperature data set reaches the first preset temperature requirement range corresponding thereto, or it can mean that the average value of all real-time temperatures reaches the first preset temperature requirement range corresponding thereto. The first preset temperature requirement range can refer to the required temperature range corresponding to the storage of the cell preparation (e.g., 1-25 degrees).

[0045] like Figure 3 As shown, in one embodiment, the liquid circuit mechanism 400 includes a driving component 420 for driving the liquid in the container to be filled 111 to flow into the filling mechanism 300; the driving component 420 includes a first driving pump 421 for driving the liquid in the container to be filled 111 to flow into the filling mechanism 300, a first switch valve 422 for controlling the on-off of the pipeline between the container to be filled 111 and the filling mechanism 300, and a third bubble sensor 423 for real-time monitoring the flow state of the liquid between the container to be filled 111 and the filling mechanism 300; the first driving pump 421, the first switch valve 422 and the third bubble sensor 423 are all installed on the housing 100.

[0046] In this embodiment, the first transmission pipeline is installed on the first driving pump 421, the first switch valve 422 and the third bubble sensor 423. The first driving pump 421 is used to drive the liquid in the to-be-packed container 111 to flow to the packing mechanism 300 through the first transmission pipeline, the first switch valve 422 is used to control the on-off of the first transmission pipeline between the to-be-packed container 111 and the packing mechanism 300, and the third bubble sensor 423 is used to monitor the flow state of the liquid in the first transmission pipeline between the to-be-packed container 111 and the packing mechanism 300 in real time.

[0047] It can be understood that the first driving pump 421 includes but is not limited to a peristaltic pump or other pump that can drive the flow of fluid. The peristaltic pump used by the first driving pump 421 can be determined according to the filling capacity of the liquid to be transferred, for example, Figure 3 In the embodiment shown in , the first driving pump 421 includes a large peristaltic pump and a small peristaltic pump; in this way, when the dispensing capacity of the liquid to be transmitted is small, the small peristaltic pump can be used, and when the dispensing capacity of the liquid to be transmitted is large, the large peristaltic pump can be used. The peristaltic pump transports the fluid by alternately squeezing and releasing the elastic delivery hose of the peristaltic pump. The peristaltic pump can rotate forward or reverse to drive the fluid (gas or liquid) to flow in different directions.

[0048] It is understandable that there may be gas in the consumable tube set when it is used for the first time. When the first driving pump 421 drives the liquid in the container to be sub-packed 111 to flow to the sub-packaging mechanism 300 through the first transmission pipeline, the gas may be injected into the sub-packaging bag 310. In addition, there may be a certain amount of gas in the sub-packaging bag 310 before use. Therefore, the first driving pump 421 can also be used to evacuate each of the sub-packaging bags 310 in the sub-packaging mechanism 300, that is, after the first driving pump 421 inputs a preset volume of liquid into the sub-packaging bag 310, the air in each of the sub-packaging bags 310 in the sub-packaging mechanism 300 can also be extracted by reversing or the like, thereby improving the sub-packaging effect.

[0049] In one embodiment, the packaging mechanism 300 also includes an air pressure sensor (not shown) connected to the first transmission pipeline and used to detect the air pressure in the first transmission pipeline. Furthermore, the air pressure sensor is connected to the end of the first transmission pipeline away from the container 111 to be packaged. It can be understood that the first transmission pipeline is connected to the packaging bag 310, and the air pressure sensor is arranged on the first transmission pipeline, that is, it can detect the air pressure in the packaging bag 310. When the air in the packaging bag 310 is extracted through the first transmission pipeline, the air pressure of the first transmission pipeline is detected by the air pressure sensor, so that the air extraction condition of the packaging bag 310 and the air tightness of the packaging bag 310 can be detected.

[0050] like Figure 1 As shown, in one embodiment, the housing 100 is provided with a mounting portion for mounting the sample container 600; the driving assembly 420 further includes a second driving pump 424 for driving the liquid in the sample container 600 to flow into the container to be dispensed 111, and a second switch valve 425 for controlling the on-off of the pipeline connecting the container to be dispensed 111 or / and the dispensing mechanism 300 with the outside world; the second driving pump 424 and the second switch valve 425 are both mounted on the housing 100; the third bubble sensor 423 is also used to monitor the flow state of the liquid between the sample container 600 and the container to be dispensed 111 in real time. Among them, the sample container 600 can be a container such as a liquid bag for holding sample liquid (such as various cell preparations that need to be dispensed). It can be understood that before the liquid is dispensed, it is first necessary to connect the sample container 600 with the container to be dispensed 111 so as to transfer the sample liquid greater than or equal to the total dispensing capacity (the total dispensing capacity is the capacity of the liquid that needs to be dispensed into all the dispensing bags 310 of the dispensing mechanism 300 this time) from the sample container 600 into the container to be dispensed 111, thereby ensuring that the liquid can be dispensed into all the dispensing bags 310 of the dispensing mechanism 300 and meet the dispensing capacity requirements.

[0051] In this embodiment, the sample container 600 is connected to the container to be dispensed 111 through the second transmission pipeline in the consumable tube group. The container to be dispensed 111 or / and the dispensing mechanism 300 are connected to the outside world through the gas pipeline in the consumable tube group. Furthermore, the end of the second transmission pipeline away from the sample container 600 is connected to the first transmission pipeline. The second transmission pipeline is installed on the second driving pump 424, so as to drive the liquid in the sample container 600 to flow into the container to be dispensed 111. One end of the gas pipeline is connected to the first transmission pipeline, and the gas pipeline is installed on the second switch valve 425, so as to control the on-off of the pipeline connecting the container to be dispensed 111 or / and the dispensing mechanism 300 with the outside world.

[0052] It is understandable that the second driving pump 424 includes but is not limited to a pump that can drive the flow of fluid, such as a peristaltic pump. The peristaltic pump used by the second driving pump 424 can be determined according to the total packaging capacity of the liquid to be transmitted. For example, when the total packaging capacity of the liquid to be transmitted is small, a small peristaltic pump can be used. When the total packaging capacity of the liquid to be transmitted is large, a large peristaltic pump can be used. The peristaltic pump transports the fluid by alternately squeezing and releasing the elastic delivery hose of the peristaltic pump. The peristaltic pump can rotate forward or reverse to drive the fluid (gas or liquid) to flow in different directions.

[0053] like Figure 1 and Figure 3 As shown, in one embodiment, the positions for installing pipelines on the first drive pump 421, the first switch valve 422, the third bubble sensor 423, the second drive pump 424 and the second switch valve 425 are all located on the same surface of the housing 100, thereby facilitating operation and use.

[0054] In one embodiment, a sterile filter is provided at one end of the gas pipeline away from the first transmission pipeline, so as to prevent bacteria and the like in the outside atmosphere from entering the consumable tube set.

[0055] like Figure 3 As shown, in one embodiment, the liquid path mechanism 400 includes a quantitative component 410 for detecting the real-time flow rate of the liquid flowing from the container 111 to be filled into the filling mechanism 300; the quantitative component 410 includes a quantitative tube 411, and a first bubble sensor 412 and a second bubble sensor 413 respectively arranged at both ends of the quantitative tube 411; the quantitative tube 411, the first bubble sensor 412 and the second bubble sensor 413 are all installed on the housing 100.

[0056] In this embodiment, the first transmission pipeline is installed on the first bubble sensor 412, the quantitative tube 411 and the second bubble sensor 413. The quantitative tube 411 can be a container with an internal space or a fixed pipeline. There is a quantitative space between the first bubble sensor 412 and the second bubble sensor 413, and the quantitative space includes the internal space of the quantitative tube 411, the space between the first bubble sensor 412 and the quantitative tube 411, and the space between the quantitative tube 411 and the second bubble sensor 413.

[0057] It can be understood that the quantitative component 410 can accurately detect the real-time flow rate of the sample liquid flowing into the dispensing mechanism 300 based on the multi-mode sensor data fusion algorithm, that is, the real-time flow rate of the first driving pump 421. Specifically, the real-time flow rate of the sample liquid flowing into the dispensing mechanism 300 is detected by the quantitative component 410, including the following steps:

[0058] S10, detecting the first time point at which the liquid flows into the quantitative space by the first bubble sensor 412; the quantitative space refers to the flow space between the first bubble sensor 412 and the second bubble sensor 413 in the first transmission pipeline; the quantitative space includes the internal space of the quantitative tube 411. That is, the first time point at which the liquid flows into the first bubble sensor 412 can be determined by the first bubble sensor 412.

[0059] S20, detecting a second time point at which the liquid flows out of the quantitative space through the second bubble sensor 413. That is, the second time point at which the liquid flows out of the second bubble sensor 413 can be determined through the second bubble sensor 413.

[0060] S30, obtain the spatial capacity of the quantitative space, and determine the real-time flow rate according to the spatial capacity, the first time point and the second time point. That is, first obtain the time difference between the first time point and the second time point, and then divide the spatial capacity of the quantitative space by the time difference to determine the current real-time flow rate of the first drive pump 421. Understandably, in the transmission process of the above-mentioned liquid, if the liquid is a cell preparation, due to the different densities and sizes of different cells in different liquids, the flow rate of the liquid in the first transmission pipeline (the quotient of the real-time flow rate of the first drive pump 421 and the cross-sectional area of ​​the first transmission pipeline) will affect the survival rate of the cells, so an initial flow rate can be pre-set according to the parameters of the liquid (including the liquid type) and the parameters of the first transmission pipeline (including the cross-sectional area of ​​the first transmission pipeline), so that the liquid flows at the initial speed to ensure cell activity, and then control the first drive pump 421 to operate at the initial flow rate, thereby driving the liquid to flow at the initial speed. However, in the actual transmission process of the liquid, the first drive pump 421 cannot operate accurately at the initial flow rate, but there will inevitably be a certain error. Therefore, for the present invention, it is necessary to determine the capacity of the liquid currently entering the filling mechanism 300 based on the real-time flow rate, and the filling amount of the liquid entering each filling bag 310 during the filling process is closely related to the above-mentioned capacity. Therefore, the actual change of the initial flow rate must be further determined, that is, the real-time flow rate is accurately determined through the above-mentioned quantitative component 410, and then the accuracy of the filling amount of the liquid entering each filling bag 310 can be guaranteed, thereby improving the filling accuracy.

[0061] In one embodiment, the liquid filling device further includes a mixing mechanism 500 installed in the heat preservation bin 110; the mixing mechanism 500 includes a mounting plate 510 and a mixing component 520; the container 111 to be filled is mounted on the mounting plate 510, and the mixing component 520 is mounted on the mounting plate 510 and is used to mix the liquid in the container 111 to be filled. It can be understood that the above-mentioned mixing process can refer to mixing the liquid in the container 111 to be filled according to pre-set mixing parameters (including but not limited to mixing frequency, mixing amplitude, mixing speed, mixing acceleration, etc.). The mounting plate 510 can be installed on the inner wall of the heat preservation bin 110.

[0062] like Figure 4 and Figure 5 As shown, in one embodiment, the mixing component 520 includes a linear motion component 521 mounted on the mounting plate 510, and a mixing plate 522 connected to the linear motion component 521 and arranged opposite to the container 111 to be dispensed; the mixing plate 522, driven by the linear motion component 521, beats or squeezes the container 111 to be dispensed, so as to mix the liquid in the container 111 to be dispensed. It can be understood that the mixing plate 522 can be arranged opposite to the first temperature control component 210, and the container 111 to be dispensed is located between the mixing plate 522 and the first temperature control component 210. The linear motion component 521 is used to output linear motion to the mixing plate 522, so that the mixing plate 522 squeezes or taps the container 111 to be dispensed arranged between the mixing plate 522 and the first temperature control component 210, so that the liquid in the container 111 to be dispensed flows upward and then sinks. While cooling the liquid in the container 111 to be dispensed, the liquid in the container 111 to be dispensed can also be mixed.

[0063] like Figure 4 and Figure 5As shown, in one embodiment, a guide hole is provided on the mounting plate 510; the linear motion assembly 521 includes a driving wheel 5211, a driven wheel 5212, a motor 5213 connected to the driving wheel 5211 and used to drive the driving wheel 5211 to rotate, a transmission belt 5214 sleeved on the driving wheel 5211 and the driven wheel 5212, a connecting block 5215 connecting the transmission belt 5214, and a guide shaft 5216 connected to the connecting block 5215; the end of the guide shaft 5216 away from the connecting block 5215 passes through the guide hole to connect to the mixing plate 522. It can be understood that the motor 5213 is used to drive the driving wheel 5211 to drive the transmission belt 5214 to rotate, and then drive the connecting block 5215, the guide shaft 5216 and the mixing plate 522 to move linearly along the guide hole through the transmission belt 5214, so that the mixing plate 522 is close to or away from the bag to be dispensed 310 installed on the mounting plate 510, thereby achieving patting or squeezing the bag to be dispensed 310, and then achieving mixing of the liquid in the bag to be dispensed 310.

[0064] like Figure 4 and Figure 5 As shown, in one embodiment, the linear motion assembly 521 further includes a linear bearing 5217 sleeved in the guide hole and used for guiding; the guide shaft 5216 is slidably connected to the guide hole through the linear bearing 5217. Further, a ball is provided at the inner wall of the linear bearing 5217, and the linear bearing 5217 is arranged between the guide hole and the guide shaft 5216. When the guide shaft 5216 moves in the linear bearing 5217 along the guide direction, it can roll with the above-mentioned ball, thereby reducing the friction force when the guide hole and the guide shaft 5216 move smoothly, thereby reducing the generation of heat, and at the same time, obtaining a smooth linear motion with high sensitivity and high precision.

[0065] like Figure 4 and Figure 5As shown, in one embodiment, the guide shaft 5216 includes a first guide shaft 5218 and a second guide shaft 5219; one end of the mixing plate 522 is rotatably connected to the first guide shaft 5218, and the other end of the mixing plate 522 is detachably connected to the second guide shaft 5219. In this embodiment, the container 111 to be dispensed is located between the mounting plate 510 and the mixing plate 522. In order to facilitate the placement of the container 111 to be dispensed, one end of the mixing plate 522 is rotatably connected to the first guide shaft 5218, and the other end of the mixing plate 522 is detachably connected to the second guide shaft 5219. Then, the mixing plate 522 can be disassembled from the second guide shaft 5219 and then rotated with the first guide shaft 5218, thereby forming a larger placement space, thereby making the placement of the container 111 to be dispensed more convenient. It can be understood that the rotation connection method includes but is not limited to hinge connection, bearing connection or rotation plug-in connection. Further, one end of the mixing plate 522 is rotatably connected to the first guide shaft 5218 through a torque hinge, so that the mixing plate 522 can be kept in a fixed position after opening without affecting the placement of the container 111 to be dispensed. The detachable connection method includes but is not limited to a snap connection, an interference connection or a pin connection. Further, the other end of the mixing plate 522 is detachably connected to the second guide shaft 5219 through a knob snap, so that the mixing plate 522 is more stable after being connected to the second guide shaft 5219 and is easy to disassemble.

[0066] like Figure 1 As shown, in one embodiment, the subpackaging mechanism 300 includes a subpackaging switch valve 320 which is arranged at the entrance of each subpackaging bag 310 in a one-to-one correspondence and is used to control the entrance switch of the subpackaging bag 310. It can be understood that an input pipeline can be arranged at the entrance of the subpackaging bag 310, and the subpackaging switch valve 320 can be arranged on the input pipeline. After opening the subpackaging switch valve 320, the liquid can flow into the subpackaging bag 310. After the subpackaging bag 310 reaches the subpackaging capacity, the subpackaging switch valve 320 is closed to ensure that all subpackaging bags 310 are filled and meet the subpackaging capacity requirements. In addition, after the subpackaging operation is completed, the input pipeline can be cut off by heat sealing, and then the replaced subpackaging bag 310 is heat-sealed and connected to the subpackaging pipeline by a sterile pipe connection machine, so that the next round of subpackaging operation can be carried out.

[0067] The above are merely embodiments of the liquid packaging equipment of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A liquid packaging device, characterized in that: include: A casing, wherein a heat preservation chamber for accommodating containers to be packaged and for keeping the containers to be packaged warm, and a packaging chamber for accommodating a plurality of packaging bags are separately arranged in the casing; A temperature control mechanism, comprising a first temperature control component installed in the heat preservation bin and used to adjust the temperature in the heat preservation bin; A sub-packaging mechanism is installed in the sub-packaging bin, and the sub-packaging mechanism is used to pack the liquid in the container to be packed into the sub-packaging bag; as well as A liquid path mechanism is installed on the housing, and is used to dispense the liquid in the container to be dispensed into the dispensing bag through the dispensing mechanism.

2. The liquid packaging equipment according to claim 1, characterized in that: The temperature control mechanism further comprises a second temperature control component installed in the sub-packaging bin and used for adjusting the temperature in the sub-packaging bin; and / or The housing further comprises a temperature control passage connected between the heat preservation chamber and the sub-packaging chamber; The temperature control mechanism also includes a temperature transmission component installed in the temperature control channel and used to control the heat exchange between the heat preservation bin and the filling bin.

3. The liquid packaging equipment according to claim 1, characterized in that: The temperature control mechanism further includes heat-insulating cotton wrapped on the inner wall of the heat-insulating bin, and a heat-insulating plate installed on the bin door of the heat-insulating bin; a heat-insulating space is formed between the heat-insulating plate and the heat-insulating cotton for heat-insulating the containers to be packaged contained in the heat-insulating bin; and / or The temperature control mechanism also includes a temperature sensor disposed in the heat preservation chamber and used for detecting the temperature in the heat preservation chamber.

4. The liquid packaging equipment according to claim 1, characterized in that: The liquid path mechanism includes a quantitative component for detecting the real-time flow rate of liquid flowing from the container to be filled into the filling mechanism; the quantitative component includes a quantitative tube, and a first bubble sensor and a second bubble sensor respectively arranged at both ends of the quantitative tube; the quantitative tube, the first bubble sensor and the second bubble sensor are all installed on the casing.

5. The liquid packaging equipment according to claim 1, characterized in that: The liquid circuit mechanism includes a driving component for driving the liquid in the container to be filled to flow into the filling mechanism; the driving component includes a first driving pump for driving the liquid in the container to be filled to flow into the filling mechanism, a first switch valve for controlling the on-off of the pipeline between the container to be filled and the filling mechanism, and a third bubble sensor for real-time monitoring the flow state of the liquid between the container to be filled and the filling mechanism; the first driving pump, the first switch valve and the third bubble sensor are all installed on the casing.

6. The liquid packaging equipment according to claim 1, characterized in that: The liquid filling equipment also includes a mixing mechanism installed in the insulation bin; the mixing mechanism includes a mounting plate and a mixing component; the container to be filled is installed on the mounting plate, and the mixing component is installed on the mounting plate and is used to mix the liquid in the container to be filled.

7. The liquid packaging equipment according to claim 6, characterized in that: The mixing component includes a linear motion component installed on the mounting plate, and a mixing plate connected to the linear motion component and arranged opposite to the container to be dispensed; the mixing plate is driven by the linear motion component to slap or squeeze the container to be dispensed to mix the liquid in the container to be dispensed.

8. The liquid packaging equipment according to claim 7, characterized in that: A guide hole is provided on the mounting plate; the linear motion assembly includes a driving wheel, a driven wheel, a motor connected to the driving wheel and used to drive the driving wheel to rotate, a transmission belt sleeved on the driving wheel and the driven wheel, a connecting block connecting the transmission belt, and a guide shaft connected to the connecting block; an end of the guide shaft away from the connecting block passes through the guide hole to be connected to the mixing plate.

9. The liquid packaging equipment according to claim 8, characterized in that: The linear motion assembly further comprises a linear bearing sleeved in the guide hole and used for guiding; the guide shaft is slidably connected to the linear bearing; and / or The guide shaft includes a first guide shaft and a second guide shaft; one end of the mixing plate is rotatably connected to the first guide shaft, and the other end of the mixing plate is detachably connected to the second guide shaft.

10. The liquid packaging equipment according to claim 1, characterized in that: The sub-packaging mechanism includes sub-packaging switch valves which are arranged at the entrances of the sub-packaging bags in a one-to-one correspondence and are used to control the opening and closing of the entrances of the sub-packaging bags.

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