Refining process and application of taurine

Abstract

The invention discloses a taurine refining process and application thereof, and relates to the technical field of taurine refining. The method specifically comprises the following steps: S1, adding ethylene oxide and sodium hydrogen sulfite into a reaction kettle, carrying out ring-opening hydroxylation to synthesize sodium isethionate, and carrying out ammonolysis, acidification and centrifugation to obtain a taurine crude product; s2, adding the taurine crude product into deionized water, heating to 90-95 DEG C, stirring until the taurine crude product is completely dissolved, adding activated carbon, performing ultrasonic treatment, and filtering while hot to obtain filtrate; s3, cooling the filtrate for the first time, adding a seed crystal, and uniformly stirring; cooling for the second time, keeping the temperature for 1-2 hours, adding an additive, and uniformly stirring; cooling for the third time, and preserving heat for 1-2 hours; centrifugally filtering and drying to obtain taurine; the taurine prepared by the process has good yield and purity and low length-diameter ratio.

Description

Technical Field

[0001] The invention relates to the technical field of taurine refining, and in particular to a taurine refining process and application thereof. Background Art

[0002] Taurine, also known as 2-aminoethanesulfonic acid, is a sulfur-containing organic acid that is widely present in animal tissues, especially in the heart, brain and retina. It is named because it was first obtained in cow bile. It participates in many physiological functions, such as bile acid binding, anti-oxidation, and regulating calcium ion balance. Taurine in the human body is synthesized by corresponding enzymes using cysteine ​​as a raw material, but the activity of cysteinesulfinic acid decarboxylase in the human body, that is, the enzyme required for synthesizing taurine, is very low. This leads to the limited ability of the human body to synthesize taurine, which cannot meet the human body's needs for taurine. Taurine is mainly taken from the outside to meet the human body's needs for taurine. As a food additive, taurine has broad market prospects and extremely high commercial value, and the research on taurine is of great practical significance.

[0003] Traditional technology uses extraction from natural organisms such as seafood. Although taurine extracted from seafood is rich in raw materials and simple to operate, the process cost is too high and cannot meet people's demand for taurine. In the prior art, taurine is synthesized industrially, and there are currently a variety of commonly used routes, such as the ethanolamine method and the ethylene oxide method. After the synthesis is completed, crystallization is the most commonly used separation and purification method in the product refining process, but the finished products of the taurine crystallization process in the prior art are mostly needle-shaped, with low bulk density and easy to break, high transportation and storage costs, and are also accompanied by low purity and low yield. Problems, therefore, the crystallization process in the refining process needs to be further improved.

[0004] In summary, in order to solve the above problems, it is of great significance to provide a refining process for taurine crystals with high yield, good purity and small aspect ratio. Summary of the invention

[0005] The purpose of the present invention is to provide a taurine refining process and application thereof to solve the problems raised in the prior art.

[0006] To achieve the above object, the present invention provides the following technical solutions: A taurine refining process comprises the following steps: S1: Add ethylene oxide and sodium bisulfite into a reactor, perform ring-opening hydroxylation to synthesize sodium isethionate, and then perform aminolysis, acidification, and centrifugation to obtain crude taurine; S2: Add the crude taurine to deionized water, heat to 90-95°C, stir until completely dissolved, add activated carbon, perform ultrasonic treatment, filter while hot, and obtain a filtrate; S3: Cool the filtrate once, add seed crystals, and stir evenly; cool it twice, keep it warm for 1-2 hours, add additives, and stir evenly; cool it three times, keep it warm for 1-2 hours; centrifuge and filter, dry, and obtain taurine.

[0007] Among them, in step S3: during the first cooling process, the temperature is reduced to 75~78°C, and the cooling rate is 10~12°C / h; during the second cooling process, the temperature is reduced to 55~58°C, and the cooling rate is 5~10°C / h; during the third cooling process, the temperature is reduced to 15~20°C, and the cooling rate is 12~15°C / h.

[0008] Preferably, the seed crystal particle size is 100-150 μm, and the added amount is 2-3 wt % of the crude taurine.

[0009] Preferably, the additive is added in an amount of 0.2-0.4 wt % of the crude taurine.

[0010] Preferably, the filtrate comprises the following raw materials, in parts by mass: 22-24 parts of crude taurine, 60-70 parts of deionized water, and 0.25-0.5 parts of activated carbon.

[0011] Preferably, the preparation method of the additive comprises the following steps: adding Tween-20, a modifier, and 2,3-diaminosuccinic acid to acetone and stirring evenly, adding ferric chloride, stirring at 80-95° C. for 10-12 hours, separating and removing the solvent, and obtaining the additive.

[0012] Preferably, the additive comprises the following raw materials, calculated by mass: 30-34 parts of Tween-20, 1-3 parts of modifier, 1-3 parts of 2,3-diaminosuccinic acid, 100-120 parts of acetone, and 0.05-0.1 parts of ferric chloride.

[0013] Preferably, the preparation method of the modifier comprises the following steps: (1) uniformly mixing 9 to 11 parts of cholic acid, 2 to 2.5 parts of N-methylmaleimide, 5 to 6 parts of dimethylacetamide, 5 to 6 parts of anhydrous ethanol and 4 to 5 parts of tetrahydrofuran, stirring at 0 to 5° C. for 10 to 15 minutes, and filtering to obtain a filtrate; (2) Add 3-5 parts of D-aminoglucosic acid to 20-24 parts of deionized water and stir evenly, add 70-80 parts of the filtrate, stir at 50-55°C for 3-4 hours, and evaporate the solvent to obtain cholylated aminoglucosic acid; (3) Add 3-5 parts of cholylated aminoglucosamine to 15-20 parts of deionized water and stir evenly, then add dropwise 55 wt% sulfuric acid solution at 15-20° C. until the pH value is 3-4, and evaporate the solvent to obtain a modifier.

[0014] Preferably, the filtrate comprises the following raw materials in parts by weight: 9 to 11 parts of cholic acid, 2 to 2.5 parts of N-methylmaleimide, 5 to 6 parts of dimethylacetamide, 5 to 6 parts of anhydrous ethanol, and 4 to 5 parts of tetrahydrofuran; The bile acylated glucosamine acid comprises the following raw materials in parts by weight: 3-5 parts of D-glucosamine acid, 20-24 parts of deionized water, and 70-80 parts of filtrate; The modifier comprises the following raw materials in parts by weight: 3 to 5 parts of cholylated aminoglucosamine acid and 15 to 20 parts of deionized water.

[0015] Preferably, the taurine prepared by the refining process can be used as a food additive.

[0016] Compared with the prior art, the present invention has the following beneficial effects: (1) The present invention adopts a multi-step cooling crystallization method to refine and crystallize the crude taurine product, improve the purity and yield of taurine crystals, improve the aspect ratio and morphology of the crystals, and improve the uniformity of the crystals. First, the temperature is lowered once to make the solution reach a saturated state, and crystal seeds are added, which helps to uniformly distribute the crystal particle size and improve the crystallization efficiency; the second cooling is to cool down to 55-58°C at a slower cooling rate of 5-10°C / h, which can reduce the crystallization rate of taurine and reduce the purity reduction caused by the introduction of impurities during the crystallization process. If the cooling rate is too fast, it will cause taurine in the mother liquor to explode into nuclei, the uniformity of the crystals will be greatly reduced, and the aspect ratio of the crystals will increase, forming needles, which are easy to break during transportation or use. After that, the temperature is kept warm so that the crystals have sufficient time to grow slowly. At this time, the introduction of Tween-20 can hinder the growth of the long axis of the crystal, thereby reducing the aspect ratio. At this time, the crystal has grown to a certain size. At this time, adding Tween-20 can reduce the impact on the purity of the crystal. If it is added too early, the crystal growth points may be less, so spontaneous nucleation will occur, reducing the uniformity and purity of the product. If too much additive is added, the adsorption on the long axis surface has long been saturated, and the hindering effect is not improved much, which increases the cost and may cause the product purity to decrease due to the increase in impurities. The long axis of the taurine crystal is mostly hydrophilic groups of amino and sulfonic acid groups. The hydrophilic segment in Tween-20 is more easily adsorbed on the long axis through hydrogen bonding, thereby closing the key growth points on the crystal surface and reducing the aspect ratio of the crystal, while the hydrophobic end helps to remove it in the subsequent washing process, thereby improving the purity. At the same time, due to the continuous precipitation of crystals, the taurine content is reduced, and the three coolings slightly increase the cooling rate, increase the crystallization rate, and thus increase production efficiency.

[0017] (2) In order to further improve the crystallization hindering effect of Tween-20 on the long axis surface, the present invention modified Tween-20 by preparing a modifier containing a sulfate group using D-aminoglucosic acid and grafting Tween-20 with 3-diaminosuccinic acid, thereby introducing carboxyl groups, amino groups and sulfate groups. The carboxyl groups and sulfate groups will form ionic bonds with the amino molecules on the long axis surface, and the amino groups will form ionic bonds with the sulfonic acid groups on the long axis surface. Compared with hydrogen bonding, the bonding is stronger, so the hindering effect is better, thereby reducing the aspect ratio of the crystal. DETAILED DESCRIPTION

[0018] Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in the field without making any creative work shall fall within the scope of protection of the present invention.

[0019] It should be noted that the purchase manufacturers of all raw materials involved in the present invention are not subject to any special restrictions and exemplarily include: Tween-20, provided by Linyi Guoli Chemical Co., Ltd.; 2,3-diaminosuccinic acid, CAS No.: 23220-52-2; cholic acid, CAS No.: 81-25-4; N-methylmaleimide, CAS No.: 930-88-1; dimethylacetamide, CAS No.: 127-19-5; D-aminoglucosic acid, CAS No.: 3646-68-2; activated carbon, CAS No.: 7440-44-0; seed crystals, with a particle size of 100~150μm.

[0020] In the following examples, parts are by mass, and the above raw materials and other raw materials used in the examples but not mentioned are all commercially available.

[0021] Example 1: Step 1: Preparation of a modifier: (1) 10 parts of cholic acid, 2.3 parts of N-methylmaleimide, 5.5 parts of dimethylacetamide, 5.5 parts of anhydrous ethanol and 4.4 parts of tetrahydrofuran were mixed evenly, stirred at 2°C for 10 minutes, and filtered to obtain a filtrate; (2) Add 4 parts of D-aminoglucosic acid to 22 parts of deionized water and stir evenly, add 75 parts of the filtrate, stir at 50°C for 3.5 hours, and evaporate the solvent to obtain cholylated aminoglucosic acid; (3) Add 4 parts of cholylated glucosamine to 15 parts of deionized water and stir evenly, add 55 wt% sulfuric acid solution dropwise at 15°C until the pH is 3-4, and evaporate the solvent to obtain a modifier; Step 2: Preparation of additives: Add 32 parts of Tween-20, 2 parts of modifier, and 2 parts of 2,3-diaminosuccinic acid to 110 parts of acetone and stir evenly, add 0.05 parts of ferric chloride, stir at 85°C for 10 hours, separate and remove the solvent, and obtain the additive; Step 3: Preparation of taurine: S1: Add ethylene oxide and sodium bisulfite into a reactor, perform ring-opening hydroxylation to synthesize sodium isethionate, and then perform aminolysis, acidification, and centrifugation to obtain crude taurine; S2: Add 23 parts of crude taurine to 65 parts of deionized water, heat to 95°C, stir until completely dissolved, add 0.5 parts of activated carbon, ultrasonically treat for 1.5 hours, filter while hot to obtain a filtrate; S3: Cool the filtrate to 76°C at a cooling rate of 11°C / h, add 2.5wt% seed crystals of crude taurine, stir evenly at 300r / min, continue to cool to 57°C at 8°C / h, keep warm for 1.5h, add 0.3wt% additive of crude taurine, stir evenly at 300r / min; cool to 15°C at 14°C / h, keep warm for 1.5h, centrifuge, filter, wash, and dry to obtain taurine.

[0022] Example 2: Step 1: Preparation of a modifier: (1) 10 parts of cholic acid, 2.3 parts of N-methylmaleimide, 5.5 parts of dimethylacetamide, 5.5 parts of anhydrous ethanol and 4.4 parts of tetrahydrofuran were mixed evenly, stirred at 2°C for 10 minutes, and filtered to obtain a filtrate; (2) Add 4 parts of D-aminoglucosic acid to 22 parts of deionized water and stir evenly, add 75 parts of the filtrate, stir at 50°C for 3.5 hours, and evaporate the solvent to obtain cholylated aminoglucosic acid; (3) Add 4 parts of cholylated glucosamine to 15 parts of deionized water and stir evenly, add 55 wt% sulfuric acid solution dropwise at 15°C until the pH is 3-4, and evaporate the solvent to obtain a modifier; Step 2: Preparation of additives: Add 32 parts of Tween-20, 2 parts of modifier, and 2 parts of 2,3-diaminosuccinic acid to 110 parts of acetone and stir evenly, add 0.05 parts of ferric chloride, stir at 85°C for 10 hours, separate and remove the solvent, and obtain the additive; Step 3: Preparation of taurine: S1: Add ethylene oxide and sodium bisulfite into a reactor, perform ring-opening hydroxylation to synthesize sodium isethionate, and then perform aminolysis, acidification, and centrifugation to obtain crude taurine; S2: Add 22 parts of crude taurine to 60 parts of deionized water, heat to 90°C, stir until completely dissolved, add 0.25 parts of activated carbon, ultrasonically treat for 1.5 hours, filter while hot to obtain a filtrate; S3: Cool the filtrate to 75°C at a cooling rate of 10°C / h, add 2wt% seed crystals of crude taurine, stir evenly at 300r / min, continue to cool to 55°C at 5°C / h, keep warm for 1.5h, add 0.2wt% additive of crude taurine, stir evenly at 300r / min; cool to 15°C at 12°C / h, keep warm for 1.5h, centrifuge, filter, wash, and dry to obtain taurine.

[0023] Example 3: Step 1: Preparation of a modifier: (1) 10 parts of cholic acid, 2.3 parts of N-methylmaleimide, 5.5 parts of dimethylacetamide, 5.5 parts of anhydrous ethanol and 4.4 parts of tetrahydrofuran were mixed evenly, stirred at 2°C for 10 minutes, and filtered to obtain a filtrate; (2) Add 4 parts of D-aminoglucosic acid to 22 parts of deionized water and stir evenly, add 75 parts of the filtrate, stir at 50°C for 3.5 hours, and evaporate the solvent to obtain cholylated aminoglucosic acid; (3) Add 4 parts of cholylated glucosamine to 15 parts of deionized water and stir evenly, add 55 wt% sulfuric acid solution dropwise at 15°C until the pH is 3-4, and evaporate the solvent to obtain a modifier; Step 2: Preparation of additives: Add 32 parts of Tween-20, 2 parts of modifier, and 2 parts of 2,3-diaminosuccinic acid to 110 parts of acetone and stir evenly, add 0.05 parts of ferric chloride, stir at 85°C for 10 hours, separate and remove the solvent, and obtain the additive; Step 3: Preparation of taurine: S1: Add ethylene oxide and sodium bisulfite into a reactor, perform ring-opening hydroxylation to synthesize sodium isethionate, and then perform aminolysis, acidification, and centrifugation to obtain crude taurine; S2: Add 24 parts of crude taurine to 70 parts of deionized water, heat to 95°C, stir until completely dissolved, add 0.5 parts of activated carbon, ultrasonically treat for 1.5 hours, filter while hot to obtain a filtrate; S3: Cool the filtrate to 78°C at a cooling rate of 12°C / h, add 3wt% seed crystals of crude taurine, stir evenly at 300r / min, continue to cool to 58°C at 10°C / h, keep warm for 1.5h, add 0.4wt% additive of crude taurine, stir evenly at 300r / min; cool to 20°C at 15°C / h, keep warm for 2h, centrifuge, filter, wash, and dry to obtain taurine.

[0024] Comparative Example 1: Based on Example 1, no additives were added, and the rest of the process remained unchanged, as follows: Step 1: Preparation of taurine: S1: Add ethylene oxide and sodium bisulfite into a reactor, perform ring-opening hydroxylation to synthesize sodium isethionate, and then perform aminolysis, acidification, and centrifugation to obtain crude taurine; S2: Add 23 parts of crude taurine to 65 parts of deionized water, heat to 95°C, stir until completely dissolved, add 0.5 parts of activated carbon, ultrasonically treat for 1.5 hours, filter while hot to obtain a filtrate; S3: Cool the filtrate to 76°C at a cooling rate of 11°C / h, add 2.5wt% seed crystals of crude taurine, stir evenly at 300r / min, continue to cool to 57°C at 8°C / h, and keep warm for 1.5h; cool to 15°C at 14°C / h, and keep warm for 1.5h, centrifuge, filter, wash, and dry to obtain taurine.

[0025] Comparative Example 2: Based on Example 1, an additive was added together with the seed crystal, and the rest of the process remained unchanged, as follows: Step 1: Preparation of a modifier: (1) 10 parts of cholic acid, 2.3 parts of N-methylmaleimide, 5.5 parts of dimethylacetamide, 5.5 parts of anhydrous ethanol and 4.4 parts of tetrahydrofuran were mixed uniformly, stirred at 2°C for 10 minutes, and filtered to obtain a filtrate; (2) Add 4 parts of D-aminoglucosic acid to 22 parts of deionized water and stir evenly, add 75 parts of the filtrate, stir at 50°C for 3.5 hours, and evaporate the solvent to obtain cholylated aminoglucosic acid; (3) Add 4 parts of cholylated glucosamine to 15 parts of deionized water and stir evenly, add 55 wt% sulfuric acid solution dropwise at 15°C until the pH is 3-4, and evaporate the solvent to obtain a modifier; Step 2: Preparation of additives: Add 32 parts of Tween-20, 2 parts of modifier, and 2 parts of 2,3-diaminosuccinic acid to 110 parts of acetone and stir evenly, add 0.05 parts of ferric chloride, stir at 85°C for 10 hours, separate and remove the solvent, and obtain the additive; Step 3: Preparation of taurine: S1: Add ethylene oxide and sodium bisulfite into a reactor, perform ring-opening hydroxylation to synthesize sodium isethionate, and then perform aminolysis, acidification, and centrifugation to obtain crude taurine; S2: Add 23 parts of crude taurine to 65 parts of deionized water, heat to 95°C, stir until completely dissolved, add 0.5 parts of activated carbon, ultrasonically treat for 1.5 hours, filter while hot to obtain a filtrate; S3: Cool the filtrate to 76°C at a cooling rate of 11°C / h, add 2.5wt% of crude taurine seed crystals and 0.3wt% of crude taurine additives, stir evenly at 300r / min, continue to cool to 57°C at 8°C / h, keep warm for 1.5h; cool to 15°C at 14°C / h, keep warm for 1.5h, centrifuge, filter, wash, and dry to obtain taurine.

[0026] Comparative Example 3: Based on Example 1, the amount of additive added was increased, and the other processes remained unchanged, as follows: Step 1: Preparation of a modifier: (1) 10 parts of cholic acid, 2.3 parts of N-methylmaleimide, 5.5 parts of dimethylacetamide, 5.5 parts of anhydrous ethanol and 4.4 parts of tetrahydrofuran were mixed uniformly, stirred at 2°C for 10 minutes, and filtered to obtain a filtrate; (2) Add 4 parts of D-aminoglucosic acid to 22 parts of deionized water and stir evenly, add 75 parts of the filtrate, stir at 50°C for 3.5 hours, and evaporate the solvent to obtain cholylated aminoglucosic acid; (3) Add 4 parts of cholylated glucosamine to 15 parts of deionized water and stir evenly, add 55 wt% sulfuric acid solution dropwise at 15°C until the pH is 3-4, and evaporate the solvent to obtain a modifier; Step 2: Preparation of additives: Add 32 parts of Tween-20, 2 parts of modifier, and 2 parts of 2,3-diaminosuccinic acid to 110 parts of acetone and stir evenly, add 0.05 parts of ferric chloride, stir at 85°C for 10 hours, separate and remove the solvent, and obtain the additive; Step 3: Preparation of taurine: S1: Add ethylene oxide and sodium bisulfite into a reactor, perform ring-opening hydroxylation to synthesize sodium isethionate, and then perform aminolysis, acidification, and centrifugation to obtain crude taurine; S2: Add 23 parts of crude taurine to 65 parts of deionized water, heat to 95°C, stir until completely dissolved, add 0.5 parts of activated carbon, ultrasonically treat for 1.5 hours, filter while hot to obtain a filtrate; S3: Cool the filtrate to 76°C at a cooling rate of 11°C / h, add 2.5wt% seed crystals of crude taurine, stir evenly at 300r / min, continue to cool to 57°C at 8°C / h, keep warm for 1.5h, add 1wt% additive of crude taurine, stir evenly at 300r / min; cool to 15°C at 14°C / h, keep warm for 1.5h, centrifuge, filter, wash, and dry to obtain taurine.

[0027] Comparative Example 4: Based on Example 1, the additive is not modified, and the other processes remain unchanged, as follows: Step 1: Preparation of taurine: S1: Add ethylene oxide and sodium bisulfite into a reactor, perform ring-opening hydroxylation to synthesize sodium isethionate, and then perform aminolysis, acidification, and centrifugation to obtain crude taurine; S2: Add 23 parts of crude taurine to 65 parts of deionized water, heat to 95°C, stir until completely dissolved, add 0.5 parts of activated carbon, ultrasonically treat for 1.5 hours, filter while hot to obtain a filtrate; S3: Cool the filtrate to 76°C at a cooling rate of 11°C / h, add 2.5wt% seed crystals of crude taurine, stir evenly at 300r / min, continue to cool to 57°C at 8°C / h, keep warm for 1.5h, add 0.3wt% of crude taurine and 0.07wt% of Tween-20 as an additive, stir evenly at 300r / min; cool to 15°C at 14°C / h, keep warm for 1.5h, centrifuge, filter, wash, and dry to obtain taurine.

[0028] Performance test: The yield, purity and aspect ratio of each embodiment and comparative example were measured, and the experimental data are shown in Table 1.

[0029] Table 1

[0030] Conclusion: It can be seen from Table 1 that in Comparative Example 1, no additives are added, which cannot hinder the crystal growth on the long axis plane, resulting in an increase in the aspect ratio; in Comparative Example 2, the additives are added together with the seed crystal, the crystal growth points are relatively small, spontaneous nucleation occurs, and the crystal purity and yield decrease; in Comparative Example 3, the amount of additives added is increased, the long axis plane of the crystal is adsorbed saturated, the aspect ratio is not greatly improved, and the purity decreases; in Comparative Example 4, the additives are not modified, and can only be bonded to the long axis plane through hydrogen bonds, the effect of hindering crystal growth is reduced, and the aspect ratio increases.

[0031] In summary, the present invention successfully provides a taurine purification process by optimizing the crystallization process and adding modified additives. The taurine has good purity and yield, and has a relatively small aspect ratio, and can be applied to food additives.

[0032] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A taurine refining process, characterized in that: The following steps are involved: S1: Add ethylene oxide and sodium bisulfite into a reactor, perform ring-opening hydroxylation to synthesize sodium isethionate, and then perform aminolysis, acidification, and centrifugation to obtain crude taurine; S2: Add the crude taurine to deionized water, heat to 90-95°C, stir until completely dissolved, add activated carbon, perform ultrasonic treatment, filter while hot, and obtain a filtrate; S3: Cool the filtrate once, add seed crystals, and stir evenly; cool it twice, keep it warm for 1-2 hours, add additives, and stir evenly; cool it three times, keep it warm for 1-2 hours; centrifuge and filter, dry, and obtain taurine.

2. A taurine refining process according to claim 1, characterized in that: In step S3: during the first cooling process, the temperature is reduced to 75-78°C, and the cooling rate is 10-12°C / h; during the second cooling process, the temperature is reduced to 55-58°C, and the cooling rate is 5-10°C / h; during the third cooling process, the temperature is reduced to 15-20°C, and the cooling rate is 12-15°C / h.

3. A taurine refining process according to claim 1, characterized in that: The seed crystal particle size is 100-150 μm, and the added amount is 2-3 wt % of the crude taurine.

4. A taurine refining process according to claim 1, characterized in that: The additive is added in an amount of 0.2-0.4 wt % of the crude taurine.

5. The process for refining taurine according to claim 1, characterized in that: The filtrate comprises the following raw materials, calculated by weight: 22-24 parts of crude taurine, 60-70 parts of deionized water, and 0.25-0.5 parts of activated carbon.

6. The process for refining taurine according to claim 1, characterized in that: The preparation method of the additive comprises the following steps: adding Tween-20, a modifier and 2,3-diaminosuccinic acid into acetone and stirring evenly, adding ferric chloride, stirring at 80-95° C. for 10-12 hours, separating and removing the solvent to obtain the additive.

7. A taurine refining process according to claim 6, characterized in that: The additive comprises the following raw materials, calculated by mass: 30-34 parts of Tween-20, 1-3 parts of a modifier, 1-3 parts of 2,3-diaminosuccinic acid, 100-120 parts of acetone, and 0.05-0.1 parts of ferric chloride.

8. The process for refining taurine according to claim 6, characterized in that: The preparation method of the modifier comprises the following steps: (1) uniformly mixing 9 to 11 parts of cholic acid, 2 to 2.5 parts of N-methylmaleimide, 5 to 6 parts of dimethylacetamide, 5 to 6 parts of anhydrous ethanol and 4 to 5 parts of tetrahydrofuran, stirring at 0 to 5° C. for 10 to 15 minutes, and filtering to obtain a filtrate; (2) Add 3-5 parts of D-aminoglucosic acid to 20-24 parts of deionized water and stir evenly, add 70-80 parts of the filtrate, stir at 50-55°C for 3-4 hours, and evaporate the solvent to obtain cholylated aminoglucosic acid; (3) Add 3-5 parts of cholylated aminoglucosamine to 15-20 parts of deionized water and stir evenly, then add dropwise 55 wt% sulfuric acid solution at 15-20° C. until the pH value is 3-4, and evaporate the solvent to obtain a modifier.

9. A taurine refining process according to claim 8, characterized in that: The filtrate comprises the following raw materials in parts by weight: 9 to 11 parts of cholic acid, 2 to 2.5 parts of N-methylmaleimide, 5 to 6 parts of dimethylacetamide, 5 to 6 parts of anhydrous ethanol, and 4 to 5 parts of tetrahydrofuran; The bile acylated glucosamine acid comprises the following raw materials in parts by weight: 3-5 parts of D-glucosamine acid, 20-24 parts of deionized water, and 70-80 parts of filtrate; The modifier comprises the following raw materials in parts by weight: 3 to 5 parts of cholylated glucosamine acid and 15 to 20 parts of deionized water.

10. An application of taurine, characterized in that: The taurine prepared by the refining process according to any one of claims 1 to 9 is used as a food additive.

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