Composition for tooth whitening or improving dentin hypersensitivity comprising polyphosphate

Abstract

The present invention relates to an oral composition containing potassium ions, phosphate ions, an organic zinc salt, and a polyphosphate, and more particularly, to a composition for tooth whitening or dentin hypersensitivity improvement containing a polyphosphate, the composition of the present invention having excellent effects of tooth whitening, tooth strength enhancement, and dentin hypersensitivity improvement, and having excellent tooth whitening, tooth strength enhancement, and dentin hypersensitivity improvement. Therefore, this composition can be effectively used in the improvement, prevention or treatment of tooth whitening, tooth strength strengthening, and dentin hypersensitivity.

Description

Technical Field

[0001] The present invention relates to a composition for whitening teeth or improving dentin hypersensitivity, comprising polyphosphate, and more particularly to a composition having an excellent whitening effect and a significant effect of improving dentin hypersensitivity. Background Art

[0002] A bright smile helps you establish a confident relationship with others. Plus, a confident smile creates a more positive first impression.

[0003] In recent years, as the interest in teeth whitening has gradually increased in addition to oral health, toothpaste compositions having teeth whitening effects have gradually been marketed.

[0004] Teeth whitening refers to a dental procedure that whitens and brightens teeth that have become discolored due to various reasons without damaging them. In recent years, teeth whitening products have been developed that can be used at home.

[0005] There are various types and methods of teeth whitening, but most of them use high-concentration hydrogen peroxide to oxidize the coloring factors of teeth for bleaching. Its whitening effect has been proven through more than 100 years of use in dentistry. Peroxide is used as an oxidizing agent to oxidize the coloring substances of teeth, deforming or decomposing the coloring substances to remove them to achieve teeth whitening, but at the same time, it is limited in storage due to its high reactivity. In addition, the oxidation reaction using hydrogen peroxide is a very irritating reaction, which will cause strong irritation when it comes into contact with lips, gums, tongue, etc.

[0006] Dentin hypersensitivity is a symptom that occurs when alveolar bone is dissolved by inflammatory reaction due to aging or disease, resulting in a decrease in the height of alveolar bone, which causes gum recession and exposes the dentin that should be located below the gum, or when teeth are temporarily weakened or thinned due to whitening toothpaste containing hydrogen peroxide or dental whitening surgery, resulting in sensitivity to external stimuli. One method that can alleviate dentin hypersensitivity is to change the balance of sodium ions and potassium ions in the oral cavity, which constitute the core of the neurotransmission system.

[0007] As a method for changing the balance of ions in the oral cavity, a method of increasing the potassium ion concentration in the oral cavity by excessive administration of potassium ions is currently used, and potassium nitrate, potassium chloride, potassium oxalate or potassium phosphate is used as the most representative substance.

[0008] On the other hand, in teeth whitening surgery or whitening toothpaste using hydrogen peroxide, the pH of the dosage form is designed to be low in order to improve the stability and efficacy of hydrogen peroxide, so that the hydroxyapatite on the surface of the teeth is dissolved by acid to produce demineralization, which may cause the teeth to become weak. As a method for strengthening teeth, there is a method of remineralization using the fluorine component contained in the toothpaste. The fluorine component is a hydroxyl group and fluoride ions that recalcify the hydroxyapatite on the surface of the teeth into fluoride apatite through an ion exchange reaction to strengthen the teeth. However, even through such a recalcification process, there is still a problem that the weakened teeth cannot be fully strengthened.

[0009] In this regard, pyrophosphate or polyphosphate has been actively studied as an excellent component for removing coloring components and inhibiting and preventing re-coloring instead of hydrogen peroxide, but low molecular weight polyphosphate forms a chelate with calcium dissolved on the tooth surface or with supersaturated calcium in saliva to cause tooth demineralization, thereby reducing the strength of the tooth. On the other hand, pyrophosphate also removes calcium on the tooth surface and reduces the hardness of the tooth.

[0010] In addition, when a remineralization agent such as calcium ions or phosphate ions, which are structural components of teeth, is simply added to solve the problem of weakened tooth strength, there is a problem that the stability of hydrogen peroxide decreases due to ion activity or the whitening effect decreases due to the formation of chelates.

[0011] Under such background, the present inventors have made intensive research and efforts to solve such problems. As a result, they have developed a toothpaste composition containing potassium ions, zinc compounds and polyphosphates and having excellent whitening effects, and confirmed that it has tooth strength strengthening and dentin hypersensitivity improving effects, which can eliminate consumers' concerns about weakened tooth strength or dentin hypersensitivity that may occur due to tooth whitening, thereby completing the present invention. Summary of the invention

[0012] Problems to be solved by the invention

[0013] An object of the present invention is to provide an oral composition comprising a potassium ion supply source, a phosphate ion supply source, an organic zinc salt (organozinc compound) and a polyphosphate.

[0014] Another object of the present invention is to provide a pharmaceutical composition for preventing or treating dentin hypersensitivity, comprising a potassium ion supply source, a phosphate ion supply source, an organic zinc salt (organozinc compound) and a polyphosphate.

[0015] Another object of the present invention is to provide a composition comprising a potassium ion source, a phosphate ion source, an organic zinc salt (organozinc compound) and a polyphosphate for use in tooth whitening, tooth strength strengthening or dentin hypersensitivity improvement.

[0016] Means for solving problems

[0017] To this, specific description is as follows. On the other hand, each description and embodiment disclosed in the present invention can also be applied to other each description and embodiment. That is, all combinations of various elements disclosed in the present invention belong to the scope of the present invention. In addition, the scope of the present invention is not limited to the following specific statements.

[0018] The present invention relates to a composition for whitening teeth and strengthening teeth or improving dentin hypersensitivity. The present invention relates to a composition comprising potassium ions capable of improving dentin hypersensitivity, an organic zinc salt capable of filling gaps in weakened teeth, and a polyphosphate having a whitening effect. The composition of the present invention has been specifically confirmed to exhibit the effects of strengthening tooth strength and improving dentin hypersensitivity while maintaining an excellent whitening effect.

[0019] Hydroxyapatite, a structural component of teeth, is produced by the reaction of calcium ions and phosphate ions contained in oral saliva and / or toothpaste. Phosphate ions react with saliva and penetrate into the tooth surface, thereby strengthening the teeth.

[0020] Potassium phosphate and zinc stearate help to increase the hardness of the tooth surface. Zinc ions replace calcium to form zinc phosphate, thereby hardening the tooth surface, thus playing an important role in the recalcification of the tooth surface. Zinc with antibacterial effects can prevent bacterial contamination and loss of dentin on the tooth surface ( Figure 1 ).

[0021] Reference Figure 1 The polyphosphate strongly contacts the tooth surface in an electrostatic way, forming a surplus negatively charged film, and introduces divalent cations with two ion binding capabilities into the formed film, through the cations and phosphate ions (PO4 3- ) through electrostatic bonding, which strengthens the teeth.

[0022] The present invention relates to a composition for achieving the purpose of simultaneously whitening teeth and strengthening tooth enamel, comprising potassium ions ( Figure 2 On the other hand, toothpaste containing potassium chloride or potassium oxalate to provide potassium ions does not affect the whitening effect while increasing the potassium ions in the microcracks of the teeth, thereby inhibiting the nerve transmission system of external stimuli such as heat and cold from reaching the dentin, thereby reducing oral irritation, but it cannot play a role in strengthening tooth strength.

[0023] As can be confirmed in the following remineralization mechanism, the phosphate ion supply source plays a role in increasing the phosphate ion (PO4 3- ) supply, thereby increasing the generation of hydroxyapatite and performing the function of filling tooth cracks. However, the mechanism by which phosphate ions are remineralized into teeth is in a competitive relationship with the formation of chelates between polyphosphates and calcium ions, thereby inhibiting the attachment of polyphosphates to teeth, thereby hindering the whitening effect. Therefore, a method is needed to include phosphate ions while maintaining the whitening effect and strengthening the strength of teeth.

[0024]

[0025] Furthermore, in the case of containing polyphosphate and zinc salt, the negative charge part of polyphosphate combines with zinc cation to form a chelate, thereby reducing the anionic charge amount (charge density) of polyphosphate, weakening the strength of binding with calcium ions on the tooth surface, and thus reducing the whitening effect of expelling and removing pollutants from the teeth. For this reason, it is very important to stably maintain the zinc salt in the dosage form. For example, zinc chloride, which can be immediately ionized in water, reacts with water to decompose into zinc ions and chloride ions, and the zinc ions form a chelate with polyphosphate, thereby weakening the binding force of polyphosphate on the tooth surface. On the contrary, organic zinc salts such as zinc citrate, zinc stearate, and zinc gluconate are formed by combining organic acids and zinc ions. Even if they come into contact with water, they are not immediately decomposed, but the stability is maintained by the electronic stability of the carboxyl group of the organic acid. Therefore, the present invention particularly uses organic zinc salts in zinc salts to maintain the stability of zinc salts in the dosage form.

[0026] In the present invention, potassium ions and phosphate ions are provided separately or simultaneously through potassium phosphate salts and coexist with organic zinc salts, so that a part of zinc ions decomposed in the composition reacts with phosphate ions other than polyphosphates, thereby maintaining the whitening effect through polyphosphates, and are combined in the form of zinc phosphate and delivered to teeth, thereby strengthening tooth strength. Therefore, it was confirmed that whitening effect, tooth strength strengthening and dentin hypersensitivity improvement effects can be achieved, and the present invention has been completed.

[0027] One embodiment of the present invention is an oral composition comprising a potassium ion supply source, a phosphate ion supply source, an organic zinc salt, and a polyphosphate.

[0028] In the present invention, the composition has one or more uses selected from the group consisting of tooth whitening, tooth strength enhancement, and dentin hypersensitivity improvement.

[0029] The term "teeth whitening" as used herein means removing substances that adhere to or penetrate into the tooth surface and the inside of the tooth matrix and cause a staining effect, or removing the staining effect by deforming the chemical structure of the substance.

[0030] The term "dentin hypersensitivity" in this specification refers to an independent disease that is sensitive to external stimuli and causes temporary or continuous pain, which is different from tooth decay or other disease causes. Dentin hypersensitivity is a condition in which the exposed dentin part of the tooth is sensitive to cold air or irritating foods. It occurs when the tooth on the gum side is exposed due to incorrect rinsing habits or excessive bite force, or when the tooth is dissolved by acid. If the oral hygiene is poor, it occurs when the tooth is dissolved by oxidation after periodontal treatment and restorative treatment. As the root cause of dentin hypersensitivity, it occurs when many fine tubes in the dentin of the tooth are exposed to the outside. All stimuli are directly transmitted to the nerves in the pulp through exposure, and the reaction to the same stimulus is more sensitive than usual, which may cause pain. Dentin hypersensitivity has a variety of symptoms ranging from mild symptoms to severe and continuous pain. Since teeth do not regenerate due to their characteristics, taking analgesics or anti-inflammatory drugs cannot fundamentally solve dentin hypersensitivity. Dentin hypersensitivity may occur in the entire tooth or locally in a specific area such as the upper or lower jaw or the right or left side. The most common site varies depending on the cause, but it mainly occurs in canines and small molars, and more than 90% of the most severe pain occurs at the boundary between the gums and the teeth, that is, the neck of the tooth.

[0031] The term "improvement" used in this specification means that the dentin hypersensitivity mentioned above is alleviated or reduced, and can be understood as a broad concept including relief, prevention, treatment, etc.

[0032] In the present invention, the above-mentioned potassium ion supply source can be one or more selected from the group consisting of potassium dihydrogen phosphate (KH2PO4), dipotassium hydrogen phosphate (K2HPO4), tripotassium phosphate (K3PO4), potassium nitrate (KNO3), potassium chloride (KCl) and potassium oxalate (K2C2O4), but is not limited thereto.

[0033] The term "potassium ion supply source" in this specification refers to a substance that can supply potassium ions (K + For example, in the case of potassium dihydrogen phosphate (KH2PO4), potassium ions (K + ) and phosphate ions (PO4 3- ) compound, and therefore can be called a potassium ion source or a phosphate ion source.

[0034] In the present invention, the above-mentioned phosphate ion supply source can be one or more selected from the group consisting of potassium dihydrogen phosphate (KH2PO4), dipotassium hydrogen phosphate (K2HPO4), tripotassium phosphate (K3PO4), sodium dihydrogen phosphate (NaH2PO4), disodium hydrogen phosphate (Na2HPO4) and trisodium phosphate (Na3PO4), but is not limited thereto.

[0035] The term "phosphate ion supply source" in this specification refers to a source that can supply phosphate ions (PO4 3- For example, in the case of potassium dihydrogen phosphate (K2HPO4), it may be a compound that can provide potassium ions (K+) and phosphate ions (PO4 3- ) compound, and therefore can be called a potassium ion source or a phosphate ion source.

[0036] In the present invention, the composition contains 0.10 to 10.00 wt % of a potassium ion source relative to the total weight of the composition, so that the composition has a stable dosage form and exhibits an excellent effect of improving dentin hypersensitivity.

[0037] Therefore, the above composition may include 0.10 to 10.00 wt%, 0.10 to 9.00 wt%, 0.10 to 8.00 wt%, 0.10 to 7.00 wt%, 0.10 to 6.00 wt%, 0.10 to 5.00 wt%, 0.10 to 4.00 wt%, 0.10 to 3.00 wt%, 0.20 to 10.00 wt%, 0.20 to 9.00 wt%, 0.20 to 8.00 wt%, 0.20 to 7.00 wt%. , 0.20 to 6.00 wt%, 0.20 to 5.00 wt%, 0.20 to 4.00 wt%, 0.20 to 3.00 wt%, 0.30 to 10.00 wt%, 0.30 to 9.00 wt%, 0.30 to 8.00 wt%, 0.30 to 7.00 wt%, 0.30 to 6.00 wt%, 0.30 to 5.00 wt% or 0.30 to 4.00 wt% of the above potassium ion supply source, more specifically, it may contain 0.10 to 3.00 wt%.

[0038] In the present invention, the composition contains 0.10 to 10.00 wt % of a phosphate ion source relative to the total weight of the composition, whereby the composition has a stable dosage form and exhibits an excellent effect of improving dentin hypersensitivity.

[0039] Thus, the above composition may comprise 0.10 to 10.00 wt%, 0.10 to 9.00 wt%, 0.10 to 8.00 wt%, 0.10 to 7.00 wt%, 0.10 to 6.00 wt%, 0.10 to 5.00 wt%, 0.10 to 4.00 wt%, 0.10 to 3.00 wt%, 0.20 to 10.00 wt%, 0.20 to 9.00 wt%, 0.20 to 8.00 wt%, 0.20 to 7.00 wt%, 0.20 to 6 .00 wt.%, 0.20 to 5.00 wt.%, 0.20 to 4.00 wt.%, 0.20 to 3.00 wt.%, 0.30 to 10.00 wt.%, 0.30 to 9.00 wt.%, 0.30 to 8.00 wt.%, 0.30 to 7.00 wt.%, 0.30 to 6.00 wt.%, 0.30 to 5.00 wt.% or 0.30 to 4.00 wt.% of the above-mentioned phosphate ion supply source, more specifically, it may include 0.10 to 3.00 wt.% of the above-mentioned phosphate ion supply source.

[0040] In the present invention, the organic zinc salt may be at least one selected from the group consisting of zinc citrate, zinc stearate, zinc gluconate, and zinc carbonate hydroxide, but is not limited thereto.

[0041] In the present invention, the organic zinc salt may not contain zinc chloride.

[0042] In the present invention, the organic zinc salt for filling the gaps between teeth is included in an amount of 0.10 to 3.00 wt % relative to the total weight of the composition, thereby exhibiting a tooth strength strengthening effect while maintaining an excellent whitening effect.

[0043] Therefore, the composition comprises 0.10 to 3.00 wt%, 0.10 to 2.80 wt%, 0.10 to 2.60 wt%, 0.10 to 2.40 wt%, 0.10 to 2.20 wt% or 0.10 to 2.00 wt% of the organic zinc salt in the composition, and more specifically, comprises 0.10 to 1.80 wt% of the organic zinc salt.

[0044] In the present invention, the polyphosphate may be one or more selected from the group consisting of linear polyphosphate, cyclic polyphosphate, and branch polyphosphate, but is not limited thereto.

[0045] In the present invention, the polyphosphate may be one or more selected from the group consisting of sodium tripolyphosphate, sodium metaphosphate, and sodium polyphosphate, but is not limited thereto.

[0046] In the present invention, the sodium metaphosphate may be sodium hexamet aphosphate, but is not limited thereto.

[0047] The term "polyphosphate" in this specification refers to a salt of a polymer oxygen anion formed by tetrahedral PO4 structural units connected together by sharing oxygen atoms. In the present invention, polyphosphate refers to a component in which the repeating unit of phosphate is 3 or more. In this specification, "phosphate ion" and "polyphosphate" need to be clearly distinguished. For example, sodium hexamethaphosphate has the structure of the following chemical formula 1.

[0048] [Chemical formula 1]

[0049]

[0050] In the present invention, 1.50 to 10.00 wt % of the polyphosphate exhibiting a teeth whitening effect is contained relative to the total weight of the composition, thereby causing less irritation to the oral cavity and exhibiting an excellent whitening effect.

[0051] Therefore, the above-mentioned composition contains 1.50 to 10.00% by weight, 1.50 to 9.00% by weight, 1.50 to 8.00% by weight, 3.00 to 10.00% by weight, 3.00 to 9.00% by weight, 3.00 to 8.00% by weight, 5.00 to 10.00% by weight, 5.00 to 9.00% by weight or 5.00 to 8.00% by weight of the above-mentioned polyphosphate in the composition, more specifically, 7.50% by weight of the above-mentioned polyphosphate.

[0052] In the present invention, the composition comprises 0.1 to 3.0 wt % of the potassium ion source, 0.1 to 3.0 wt % of the phosphate ion source, 0.1 to 3.0 wt % of the organic zinc salt and 1.5 to 10.0 wt % of the polyphosphate, but is not limited thereto.

[0053] The above-mentioned composition can be applied to any oral product for teeth whitening, tooth strength strengthening or improving dentin hypersensitivity in the oral cavity, without particular limitation, and can be, for example, toothpaste, oral spray, oral rinse, oral ointment, mouth freshener, chewing gum, candy, oral patch, etc. The above-mentioned oral product can be in liquid, solid, suspension, colloid, film, patch form, but is not limited thereto. When the composition of the present invention is formed in the form of a patch, the above-mentioned patch can be formed in a form that can be peeled off after being dissolved in the oral cavity or attached to the oral cavity, and the form of the patch is not limited.

[0054] The product produced by the composition of the present invention can be produced by a method commonly used in the industry.

[0055] In order to apply the composition of the present invention to oral products, appropriate additives, carriers, etc. may be additionally contained in the above composition. Those skilled in the art can appropriately select and combine the above additives and carriers, etc.

[0056] The ingredients contained in the oral product using the composition of the present invention may include, in addition to the composition containing the above-mentioned potassium ions, phosphate ions, organic zinc salts and polyphosphates, ingredients commonly used in oral products, such as abrasives, wetting agents, binders, bubbling agents, sweeteners, preservatives, medicinal ingredients, flavoring agents, pigments, solvents, whitening agents, co-solvents or pH adjusters.

[0057] Another aspect of the present invention provides a pharmaceutical composition for preventing or treating dentin hypersensitivity, comprising a composition containing a potassium ion source, a phosphate ion source, an organic zinc salt, and a polyphosphate.

[0058] The term "prevention" used in this specification refers to any action to suppress or delay the occurrence of dentin hypersensitivity by administering the above-mentioned composition.

[0059] The term "treatment" used in this specification refers to any action that improves or contributes to the improvement of dentin hypersensitivity by administering the above-mentioned composition.

[0060] The pharmaceutical composition of the present invention may further comprise a pharmaceutically acceptable carrier.

[0061] The term "pharmaceutically acceptable" as used herein means that the drug does not irritate a subject when administered and does not inhibit the biological activity and properties of the administered compound, and is generally used in the pharmaceutical field.

[0062] The term "subject" used in this specification refers to mammals including humans, such as humans, monkeys, cows, horses, sheep, pigs, cats, dogs, mice, rats, rabbits or guinea pigs, but is not limited thereto.

[0063] The term "administer" in this specification means providing a predetermined substance to a subject by any appropriate method, and the administration route of the pharmaceutical composition of the present invention may be any general route as long as it can reach the target tissue.

[0064] In the present invention, about carrier, as long as it is the carrier commonly used in the art, can be used arbitrarily.As the non-limitative example of carrier, can be physiological saline, sterile water, Ringer's solution, buffered physiological saline, albumin injection, lactose, glucose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, maltodextrin, glycerol, ethanol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methylcellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methyl hydroxybenzoate, propyl hydroxybenzoate, talcum powder, magnesium stearate, mineral oil or their combination etc.

[0065] In the present invention, as required, the pharmaceutical composition may be added with other pharmaceutically acceptable additives such as molding agents, diluents, antioxidants, buffers or antibacterial agents, and may be used with additional fillers, extenders, wetting agents, disintegrants, dispersants, surfactants, binders or lubricants.

[0066] Effects of the Invention

[0067] The present invention relates to an oral composition comprising potassium ions, phosphate ions, organic zinc salts and polyphosphates. The composition of the present invention has the effects of whitening, strengthening tooth strength and improving dentin hypersensitivity. BRIEF DESCRIPTION OF THE DRAWINGS

[0068] Figure 1 Schematic diagram showing the recalcification process of the tooth surface of the composition according to one embodiment of the present invention.

[0069] Figure 2 This is a schematic diagram showing the process of potassium ions penetrating into micro cracks between teeth to improve dentin hypersensitivity. DETAILED DESCRIPTION

[0070] Below, the present application is described in more detail by examples. However, the following examples are only for illustrating the preferred implementation of the present application, and therefore the scope of the present application is not limited thereto. On the other hand, those skilled in the art can fully understand and easily implement the technical matters not recorded in this specification.

[0071] Production Example: Production of Compositions of Examples and Comparative Examples

[0072] In order to confirm the effects of the composition changed according to the structural components and the content, the compositions of Examples 1 to 10 and Comparative Examples 1 to 6 were produced.

[0073] Specifically, carrageenan and xanthan gum were mixed in glycerin and polyethylene glycol, purified water was added, a small amount of raw materials were added to dissolve, and then inorganic solid powder, surfactant and flavor were added to prepare an oral composition. The specific ingredients and contents are shown in Tables 1 and 2 below.

[0074]

Table 1

[0075]

[0076]

Table 2

[0077]

[0078] Experimental Example 1: Confirmation of teeth whitening effect in vitro (confirmation of stain removal power)

[0079] The teeth whitening effect of the compositions of the examples and comparative examples was confirmed using hydroxyapatite disks. Hydroxyapatite is a material used as artificial teeth and for repairing tissues, and the ability of the compositions of the examples and comparative examples to remove contaminants from hydroxyapatite disks was measured as follows.

[0080] Specifically, hydroxyapatite powder was stirred with a polyvinyl alcohol aqueous solution and pressed with a compressor at a pressure of more than 10 tons, and then sintered at 1,000°C to produce a hydroxyapatite disc. The hydroxyapatite disc was stained with coffee, tea, and mucus to prepare a test piece, and was brushed 5,400 times with a toothbrush with a load of 250g. In addition, the stain removal ability was evaluated by measuring the color change with a Minolta CR-321 colorimeter, which is recorded in the following Tables 3 and 4.

[0081]

Table 3

[0082]

[0083]

Table 4

[0084] Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Stain removal 16.50 18.70 12.57 25.10 15.32 13.24 Standard Deviation 6.81 6.21 5.26 4.05 5.99 6.98

[0085] As a result, as shown in Tables 3 to 4 above, in the compositions of Examples 1 to 10 containing potassium ions, phosphate ions and organic zinc salts in addition to polyphosphates showing a teeth whitening effect, stain removal powers ranging from a minimum of 24.10 (Example 1) to a maximum of 27.78 (Example 2) were measured, thereby confirming an excellent whitening effect.

[0086] In particular, it was confirmed that the compositions of Examples 1 to 10 had similar or superior whitening effects as compared with the composition (25.10) of Comparative Example 4 which did not contain potassium ions, phosphate ions, and organic zinc salts but contained only polyphosphate.

[0087] Furthermore, it was confirmed that the compositions of Examples 1 to 10 had a more excellent whitening effect than the compositions not containing potassium ions (Comparative Examples 1, 3, and 5) or not containing phosphate ions (Comparative Examples 3 and 5) or not containing organic zinc salts (Comparative Examples 1, 2, and 6).

[0088] Therefore, it was confirmed that a more excellent whitening effect was achieved when the structural components of potassium ions, phosphate ions, organic zinc salts, and polyphosphates were appropriately combined, but when potassium ions, phosphate ions, or zinc salts were used alone, the teeth whitening effect was significantly reduced.

[0089] Experimental Example 2: Confirmation of the effect of strengthening teeth

[0090] Using the compositions produced in the above-mentioned Production Examples, changes in tooth hardness were evaluated.

[0091] Specifically, the evaluation method is as follows: a tooth specimen is prepared by drilling with a small tooth and installing with an appropriate tool and then grinding. After etching the specimen with 0.1M lactic acid, the initial hardness is measured with a Vickers hardness tester. After grouping 8 test specimens for each group, the following pH cycle (5 times) is performed to measure the final hardness.

[0092]

[0093] Detailed hardness analysis was performed after caries formation (T1) and after remineralization treatment (T2), and the results are shown in Tables 5 and 6 below.

[0094]

Table 5

[0095]

[0096]

Table 6

[0097]

[0098] As a result, as shown in Tables 5 and 6, it was confirmed that the tooth hardness in Examples 1 to 10 was significantly improved compared to Comparative Example 4 which did not contain potassium ions, phosphate ions, and an organic zinc salt. In addition, compared to Comparative Example 6 which contained zinc chloride in which zinc was unstable, the tooth strengthening effect was higher in the case of using a zinc salt stabilized as an organic acid. This means that in the case of Comparative Example 6, zinc reacted in advance in the dosage form and did not affect the tooth strengthening effect.

[0099] Therefore, it was confirmed that the composition of the present invention has an excellent teeth whitening effect and also has an effect of strengthening the hardness of teeth.

[0100] Experimental Example 3: Confirmation of the effect of improving dentin hypersensitivity

[0101] The values ​​were measured using electric pulp test (EPT) on volunteers.

[0102] Regarding the pulp electrical activity test method using a dentin hypersensitivity measuring tool, a published paper (KIM, Young-Sung, Journal of Periodontal and Implant Science, Volume 32 Issue 2, 371-378, 2002) was referred to, and a higher value than that of the previous measurement was evaluated as having a dentin hypersensitivity improvement effect.

[0103] The baseline electrical activity test of the dental pulp was conducted before using the composition in each experiment, and was re-conducted 2 weeks after using the composition, which are shown in Tables 7 and 8 below.

[0104]

Table 7

[0105]

[0106]

Table 8

[0107]

[0108] As a result, as shown in Tables 7 and 8, the compositions of Examples 1, 3, 6 and 7 containing potassium ions, phosphate ions, organic zinc salts and polyphosphates have enhanced resistance to stimulation compared to the compositions of Comparative Examples 1 and 4 not containing these, and thus it was confirmed that the effect of improving dentin hypersensitivity was superior. On the contrary, the composition (Comparative Example 4) not containing potassium ions, phosphate ions and zinc salts increased sensitivity to stimulation, and dentin hypersensitivity was somewhat aggravated.

[0109] In summary, the results of the above experimental examples show that the composition of the present invention comprising potassium ions, phosphate ions, organic zinc salts and polyphosphates can effectively improve the strength of teeth and improve dentin hypersensitivity while maintaining an excellent tooth whitening effect, by confirming the whitening effect, tooth strengthening effect and dentin hypersensitivity improvement effect. Therefore, it is revealed that the composition of the present invention can be effectively used for tooth whitening, tooth strength strengthening and dentin hypersensitivity improvement.

[0110] Those skilled in the art can understand based on the above description that the present invention can be implemented in other specific forms without changing its technical ideas or essential features. In this regard, it should be understood that the embodiments described above are illustrative in all aspects and the present invention is not limited thereto. The scope of the present invention should be interpreted as that all changes or deformations derived from the meaning and scope of the claims described below and their equivalent concepts are included in the scope of the present invention compared to the above detailed description.

Claims

1. An oral composition comprising a potassium ion supply source, a phosphate ion supply source, an organic zinc salt and a polyphosphate.

2. The composition according to claim 1, wherein The potassium ion supply source is one or more selected from the group consisting of potassium dihydrogen phosphate (KH2PO4), dipotassium hydrogen phosphate (K2HPO4), tripotassium phosphate (K3PO4), potassium nitrate (KNO3), potassium chloride (KCl) and potassium oxalate (K2C2O4).

3. The composition according to claim 1, wherein The above-mentioned phosphate ion supply source is one or more selected from the group consisting of potassium dihydrogen phosphate (KH2PO4), dipotassium hydrogen phosphate (K2HPO4), tripotassium phosphate (K3PO4), sodium dihydrogen phosphate (NaH2PO4), disodium hydrogen phosphate (Na2HPO4) and trisodium phosphate (Na3PO4).

4. The composition according to claim 1, wherein The organic zinc salt is at least one selected from the group consisting of zinc citrate, zinc stearate, zinc gluconate, and zinc carbonate hydroxide.

5. The composition according to claim 1, wherein The polyphosphate is at least one selected from the group consisting of linear polyphosphate, cyclic polyphosphate, and branched polyphosphate.

6. The composition according to claim 1, wherein The polyphosphate is at least one selected from the group consisting of sodium tripolyphosphate, sodium metaphosphate, and sodium polyphosphate.

7. The composition according to claim 6, wherein The sodium metaphosphate mentioned above is sodium hexametaphosphate.

8. The composition according to claim 1, wherein The composition comprises 0.1 to 3.0 wt % of the potassium ion source, 0.1 to 3.0 wt % of the phosphate ion source, 0.1 to 3.0 wt % of the organic zinc salt, and 1.5 to 10.0 wt % of the polyphosphate.

9. The composition according to any one of claims 1 to 8, wherein The composition has one or more uses selected from the group consisting of tooth whitening, tooth strength enhancement, and dentin hypersensitivity improvement.

10. An oral product comprising the composition according to any one of claims 1 to 8.

11. The oral product according to claim 10, wherein: The oral product is at least one selected from the group consisting of toothpaste, oral spray, oral rinse, oral ointment, mouth freshener, chewing gum, candies, and oral patches.

12. A pharmaceutical composition for preventing or treating dentin hypersensitivity, comprising the composition according to any one of claims 1 to 8.

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