Efficient oil-removing and itching-relieving shampoo

Abstract

According to the efficient oil-removing and itching-relieving shampoo provided by the invention, through auxiliary cooperation of a surfactant combination and additives, the prepared shampoo has the effects of removing dandruff, relieving itching, sterilizing, inhibiting bacteria, removing oil, resisting cold and heat, being high in stability, low in irritation to skin, fresh and pleasant, and good in moisturizing and nutrition functions, and in addition, the shampoo can effectively remove grease and inhibit grease secretion, so that the shampoo is free of toxic and side effects. The shampoo can regulate water-oil balance, repair scalp barrier, maintain the steady state of scalp environment, and is refreshing and non-sticky for a long time.

Description

Technical Field

[0001] The invention relates to the technical field of washing and care products, and in particular to a highly effective oil-removing and itching-relieving shampoo. Background Art

[0002] Since the 1970s, people have started to use hair care products in their daily lives. In recent years, with the improvement of people's living standards and the gradual enhancement of awareness of hygienic hair care, coupled with the influence of advertising effects, the global production of hair care shampoo has grown rapidly at an annual rate of 7%. Among them, anti-dandruff shampoo with antipruritic, conditioning, and hair care functions is generally popular, and its sales volume has grown the fastest. The proportion of anti-dandruff shampoo has grown from the initial 15% to the current 35%, and this number is still rising. As a result, it is necessary to develop and research efficient and safe antiseptic and antipruritic agents. However, as such fungicides, they should meet the following conditions: ① non-toxic, no odor, non-irritating or low irritating; ② the antifungal effect should be obvious; ③ good stability; ④ good compatibility. Therefore, the development of such anti-dandruff and antipruritic products has become an inevitable trend.

[0003] The epidermal cells on the head are similar to the physiological conditions of the skin in other parts of the body. They are also undergoing metabolism. After proliferating in the basal layer, they gradually mature to form a stratum corneum, and then become tiny powders and fall off. This is a normal physiological metabolism of the stratum corneum and epidermis of the head. However, due to the increase in sebum secretion, the action of microbial bacteria, and the influence of internal and external factors such as sebum lyase, the metabolism of the scalp stratum corneum is incomplete, which makes people feel itchy on the head and produces snowflake-like dandruff, which not only brings inferiority and distress to the person, but also makes others feel uncomfortable. Excessive dandruff and scalp itching are a common scalp disease. In medicine, dandruff is called "pityriasis capitis" and "seborrheic dermatitis". The manifestations are divided into dry and oily dandruff. Dry dandruff is white or grayish white, loosely distributed on the hair, and easily falls off in a scaly form when combing the hair; oily dandruff is grease-like light yellow flakes, usually attached to the scalp or hair, and not easy to fall off. From a scientific point of view, dandruff is the dead skin pieces in the normal metabolism of scalp cells. A large number of studies have shown that dandruff is a seborrheic dermatitis that occurs on the scalp. The occurrence of dandruff is directly related to the number of Malassezia furfur. When its number is within the normal range, the stratum corneum has 25-35 layers of tightly bound complete keratinized cells and is also in a normal metabolic process. However, when the reproduction of Malassezia increases abnormally, the metabolic rate of scalp cells is accelerated, the tight structure between the scalp keratin cells and the intercellular lipid layer is destroyed, the content of saturated fatty acids in the cortex is greatly reduced, the scalp becomes more sensitive, the thickness of the scalp stratum corneum is reduced to less than 10 layers of cells, the aging and shedding of the stratum corneum is accelerated, and it is very easy to cause itching, hair loss and excessive dandruff.

[0004] There are many factors that cause excessive dandruff, including external chemical stimulation, mechanical factors, excessive dust in the environment, dust mixed with sebum secreted by the scalp, and dandruff after drying, as well as the growth of microorganisms (bacteria, fungi), resulting in seborrheic dermatitis, etc. There are also internal factors such as excessive secretion of sebum hormones by the human body, unbalanced diet, malnutrition, and secretion disorders caused by physical fatigue, excessive brain use and mental stress; of course, the fungus in the scalp - Malassezia furfur is the main cause of excessive dandruff and scalp itching. Malassezia is a highly lipophilic fungus that mainly exists in the hair follicles and stratum corneum of the sebum secretion area of ​​the human skin, including the head skin. When it reproduces abnormally, it will cause abnormal proliferation of keratinocytes on the scalp. In view of the above factors, the key to solving the problem of dandruff and itching is not only to adjust eating habits and the physiological and psychological state of the human body, but also to inhibit or kill pathogenic fungi, eliminate the root causes of itching and dandruff, and clean the scalp to achieve the purpose of dandruff and itching. In this case, it is necessary to develop some bactericidal and antipruritic agents and add them to hair cosmetics such as shampoo and conditioner. The anti-dandruff ingredients can act on the scalp while washing and conditioning the hair, reducing the number of Pityrosporum to normal levels, thereby inhibiting excessive oil secretion, helping scalp cells to return to a healthy state, keeping the scalp clean, reducing excessive proliferation of scalp cells, and inhibiting excessive dandruff.

[0005] The most widely used are synthetic anti-dandruff agents, which are easy to mass-produce, have abundant raw material sources and are relatively cheap. The earlier anti-dandruff agents include sulfur powder, selenium disulfide and salicylic acid. The anti-dandruff effect of sulfur powder is not very ideal, and it only has a bactericidal effect. The anti-dandruff effect can generally only last for one day, or even less than one day, and it is very irritating; salicylic acid is not suitable for children because it is easily absorbed by the skin; selenium disulfide is not easy to rinse thoroughly and has the side effect of making the scalp too dry, discoloring the hair, and causing hair loss. The commonly used and effective anti-dandruff and antipruritic agents in the domestic market include undecylenic acid derivatives, selenium sulfide, zinc pyrithione, active climbazole, etc.

[0006] Selenium sulfide (SeS2) and selenium sulfide zinc are two highly effective anti-itch and anti-dandruff compounds, which achieve the purpose of anti-dandruff and anti-itch by reducing the rate of epidermal renewal and inhibiting the rate of cell keratinization. Selenium disulfide is a low-toxic and highly effective anti-dandruff raw material.

[0007] However, selenium disulfide has two major problems in practical application: discoloration and coagulation. In view of this problem, CN115721571B discloses a composition and shampoo for preventing selenium disulfide from discoloring. The composition includes zinc salt and selenium disulfide in a mass ratio of 0.1-30:0.1-2.5, the zinc salt is one or more of zinc salt surfactant, PCA zinc, zinc sulfate, and zinc gluconate, and the zinc salt surfactant is one or more of zinc cocoyl alcohol polyether sulfate, zinc oleate, and zinc undecylenate; preferably zinc cocoyl alcohol polyether sulfate or PCA zinc. The shampoo using the composition can effectively overcome the high-temperature discoloration of selenium disulfide. A shampoo containing the above composition for preventing selenium disulfide from discoloring is provided. On the basis of overcoming the high-temperature discoloration of selenium disulfide, it has excellent oil control and anti-dandruff effects, reasonable component design, solves the discoloration problem of selenium disulfide at high temperature, and has low production cost; at the same time, zinc ions can destroy the activity of bacterial cell synthases, making it impossible for bacteria to reproduce and grow, and cooperate with selenium disulfide to inhibit bacteria and control oil. CN111544332A A kind of anti-dandruff shampoo and its preparation method, the total mass of the raw materials of the anti-dandruff shampoo is 100%, and the raw materials include the following components in mass percentage: anionic surfactant 10-30%, nonionic surfactant 0.01-1%, amphoteric surfactant 0.5-6%, pearlescent agent 0.5-2.5%, hair conditioner 0.6-8%, viscosity modifier 0.01-2%, stabilizer 0.1-1.5%, buffer 0.1-1%, first anti-dandruff agent 0.01-1% and the balance of water; the first anti-dandruff agent contains selenium disulfide. The present invention has good anti-dandruff effect by rationally compounding the raw materials and synergizing, and can effectively relieve scalp itching and make hair more supple; and the product is not easy to change color, has good stability, is gentle to use, and is safe and non-irritating. For example, CN116672273A relates to a porous SiO2 composite, in particular to a SeS2 porous SiO2 composite and a preparation method thereof, and also to a liquid composition containing the composite. Among them, the median particle size D50 of the SeS2 porous SiO2 composite provided is less than or equal to 5.0 μm; the preparation method of the SeS2 porous SiO2 composite provided includes the steps of: dispersing SeS2 in silica sol to obtain a composite sol, and aging, drying, and granulating the composite sol; the provided liquid composition includes a SeS2 porous SiO2 composite, a siloxane, and a necessary surfactant. The technical solution of the present invention improves the suspension stability of selenium disulfide, while improving the stability of SeS2, and solves the technical problems of SeS2 being easy to change color and unevenly dispersed. It can be clearly seen that the prior art mainly improves the problem of unstable discoloration of vulcanized shoes by the proportion and combination of the composition. Summary of the invention

[0008] Based on the problems existing in the prior art, the present invention provides a highly efficient oil-removing and itching-relieving shampoo, which has the functions of removing dandruff, relieving itching, sterilizing, inhibiting bacteria, removing oil, being cold-resistant and heat-resistant, highly stable, having low irritation to the skin, being refreshing and pleasant, and having excellent moisturizing and nutritional functions. In addition, the shampoo can effectively remove grease, inhibit grease secretion, regulate water-oil balance, repair the scalp barrier, maintain the homeostasis of the scalp environment, and keep the scalp fresh and non-greasy for a long time.

[0009] A highly effective oil-removing and itching-relieving shampoo is prepared from the following raw materials in the following mass ratios: 25% active substance LSA ammonium lauryl sulfate 21.31%; 70% active substance AESA ammonium lauryl polyoxyethylene ether sulfate 16.22%; Coconut oil monoethanolamide CMEA 0.93%; Octyldodecanol higher alcohol 0.82%; Pearlescent diester 1.78%; Caprylic / capric glyceride GTCC 0.23%; Silicone oil content 50% large particle size emulsified silicone oil 4.23%; Polyquaternium-10 0.41%; 0.021% of polyethylene oxide having a number average molecular weight of more than 1 million; Citric acid 0.017%; NaH2PO4-Na2HPO4 0.18%; Sodium chloride 0.23%; Inorganic anti-dandruff and antipruritic agents 8-12%; Kaison 0.081%; Fragrance 0.59%; Silk peptide powder 0.13%; Ammonium xylenesulfonate 0.059%; Deionized water balance.

[0010] The particle size range of large particle size emulsified silicone oil is D50=15-25μm.

[0011] The inorganic anti-dandruff and antipruritic agent is nitrogen-mixed carbon-based selenium disulfide. The selenium sulfide is highly dispersed on the surface of the nitrogen-mixed carbon material, with a particle size of 10-20 nm and a mass loading of ≥8.3%.

[0012] The nitrogen-hybridized carbonyl selenium disulfide is prepared by the following steps: (1) In a 50 mL reaction container, 40-50 mg of benzamide, 150-160 mg of diphenyl diselenide, 5-6 mg of triruthenium dodecacarbonyl, 7-8 mg of silver hexafluoroantimonate, 50-55 mg of anhydrous silver acetate, 4-5 ml of ethanol, and 2-4 ml of DMF were added in sequence, and reacted at 95-100° C. for 24-28 hours under an inert atmosphere. After natural cooling, 20-30 mL of deionized water was added, and then the organic layer was extracted with water, and then washed, dried, concentrated under reduced pressure, and subjected to silica gel column chromatography to obtain a selenized organic carrier; (2) 40-50 mL of selenized organic carrier, 4-5 mL of formaldehyde, and 100-120 ml of deionized water are placed in a hydrothermal reactor, the air in the hydrothermal reactor is exhausted in advance with nitrogen, and 1.5 atmospheres of nitrogen are applied to the hydrothermal reactor, the nitrogen valve is closed, the reactor is sealed, and the reaction system is reacted at 250°C-300°C in the hydrothermal reactor for 4-5 hours under heating conditions. After natural cooling, the reaction is filtered, washed, and taken out to obtain nitrogen-hybridized carbon-based selenide; (3) Passing sublimated sulfur gas into the nitrogen-hybridized carbon-based selenide, fully reacting at 150-160°C for 10-12 hours, cooling naturally, and taking out; (4) placing the sample prepared in step (3) in a nitrogen tube furnace and heat treating at 120-125° C. for 4-5 h; (5) After natural cooling, place the mixture in deionized water for ultrasonic treatment for 20-30 min, filter, vacuum dry, and seal in plastic to obtain nitrogen-hybridized carbonyl selenium disulfide.

[0013] Shampoo is mainly composed of surfactants, generally anions, with a certain amount of non-ionic, zwitterionic and some high molecular cationic surfactants. The surfactant of the present invention is a composite surfactant, including anionic surfactant ammonium dodecyl sulfate, nonionic surfactant ammonium dodecyl polyoxyethylene ether sulfate and coconut oil monoethanolamide, forming a mixed surfactant micelle solution with suitable dirt removal and oil removal capabilities. Ammonium dodecyl sulfate (LSA) is widely used in shampoo due to its low irritation, excellent foaming ability and low degreasing power. The sulfonation rate of LSA directly affects the viscosity, foam and odor of the product, which is caused by the oil (fatty alcohol) and salt content. The biggest disadvantage of LSA is that it is easily hydrolyzed, which is due to its fragile ester bond structure. Low pH (<4.5) or high temperature for a long time (>60°C, more than tens of minutes) will cause LSA to hydrolyze, thereby producing oil and inorganic salts. When pH>7, LSA will decompose and release ammonia, so the pH value of the LSA system shampoo should be between 5-6.5. The pH value of the present invention is about 5.5. It is necessary to comprehensively consider the problem that selenium sulfide is easy to change color at pH=4-5.

[0014] The only difference between AESA and AES is that they are ammonium salts or sodium salts. They are less irritating and have a lower degreasing rate than AES, and have better water solubility and higher stability than LSA. When used in combination with LSA, a stable high-foaming system can be obtained. Coconut oil-based monoethanolamide is compounded with anionic surfactants, which can generally increase viscosity and stabilize foam.

[0015] The pearlescent diester forms a delicate pearl with a strong texture. In the shampoo system, it exists in a dissolved or emulsion state when the temperature is high, and precipitates in the form of flaky crystals when the temperature is low. Since its refractive index is quite different from that of the aqueous solution, we can see a little bit of light reflection, which is usually called pearlescent. The precipitation rate of pearlescent diester pearlescent crystals is high, the pearlescent appearance is good, and adding it to shampoo has little effect on the foam.

[0016] Polyquaternium-10 high molecular cationic surfactants, on the one hand, rarely react directly with anionic surfactants due to their cationic groups due to steric hindrance; on the other hand, the more hydrophilic groups in the polymer always keep the molecules water-soluble, and will not precipitate when encountering anionic surfactants like small molecular cationic surfactants, which makes it possible to use high molecular cationic compounds in shampoo. It is also because of their cationicity and many hydrophilic groups that they have strong charge bonding and hydrogen bonding with hair protein molecules, and are not easily washed away during shampooing. They have both the properties of cationic surfactants and the characteristics of high molecular compounds, so they have both antistatic effects and moisturizing effects, and significantly improve wet combing properties. They also help the viscosity and stability of shampoo and increase the adsorption of silicone oil on hair.

[0017] Octyldodecanol is an oily substance that can improve the combing properties of shampoo. Since octyldodecanol has a high melting point, it will precipitate from a solubilized state to a dispersed state during the cooling process of the shampoo, and its influence on the foam of the shampoo becomes smaller. It is an ideal smoothing softener. In order to reduce the degreasing power of the shampoo, the present invention appropriately adds a small amount of octyl decanoate glyceride oily substance, which is helpful for improving the combing properties.

[0018] Silicone oil is a very good lubricant that can greatly reduce frictional resistance. Since small molecular weight dimethylsiloxane is an excellent defoamer, the silicone oil used in shampoo must be a high molecular weight, high viscosity silicone oil. Similarly, in order to prevent silicone oil from being easily washed off during shampooing, it is required that the silicone oil be dispersed in the shampoo with a certain particle size. Too large particles tend to float, while too fine particles indicate a stable emulsion, which has a weak tendency to adsorb on the hair and a reduced adsorption amount.

[0019] The pH value of shampoo is generally controlled in the weak acid range close to human skin, and many surfactants are alkaline, so citric acid is often used to adjust the pH. On the one hand, the salt generated by the neutralization of organic acid and alkali does not have a strong electrolyte effect like inorganic salts, and on the other hand, it also has the effect of a chelating agent, which is beneficial to the stability of shampoo.

[0020] The inorganic anti-dandruff and antipruritic agent of the present invention is nitrogen-mixed carbon-based selenium disulfide, and the selenium sulfide is highly dispersed on the surface of the nitrogen-mixed carbon material, with a particle size of 10-20nm and a mass loading of ≥8.3%. The specific preparation method is: (1) In a 50 mL reaction container, 40-50 mg of benzamide, 150-160 mg of diphenyl diselenide, 5-6 mg of triruthenium dodecacarbonyl, 7-8 mg of silver hexafluoroantimonate, 50-55 mg of anhydrous silver acetate, 4-5 ml of ethanol, and 2-4 ml of DMF were added in sequence, and the mixture was reacted at 95-100° C. for 24-28 h under an inert atmosphere. After natural cooling, 20-30 mL of deionized water was added, and then the organic layer was extracted with water, and then washed, dried, concentrated under reduced pressure, and subjected to silica gel column chromatography to obtain a selenized organic carrier.

[0021] (2) 40-50 mL of selenized organic carrier, 4-5 mL of formaldehyde, and 100-120 ml of deionized water are placed in a hydrothermal reactor. The air in the hydrothermal reactor is expelled with nitrogen in advance, and 1.5 atmospheres of nitrogen is applied to the hydrothermal reactor. The nitrogen valve is closed, and the reactor is sealed. The reaction system is allowed to react at 250°C-300°C in the hydrothermal reactor under heating conditions for 4-5 hours. After natural cooling, the reaction is filtered, washed, and taken out to obtain nitrogen-hybridized carbon-based selenide.

[0022] (3) Sublimed sulfur gas is introduced into the nitrogen-hybridized carbon-based selenide, and the mixture is fully reacted at 150-160°C for 10-12 hours, cooled naturally, and removed.

[0023] (4) Place the sample prepared in step (3) in a nitrogen tube furnace and heat treat it at 120-125°C for 4-5 hours.

[0024] (5) After natural cooling, the mixture is placed in deionized water for ultrasonic treatment for 20-30 minutes, filtered, vacuum dried, and plastic-sealed to obtain an inorganic anti-dandruff and antipruritic agent.

[0025] Under the catalytic guidance of triruthenium dodecacarbonyl, benzamide is selenylated by diphenyl diselenide to obtain N-isopropyl-2-phenylselenoyltoluamide. The naming method may be inaccurate or wrong, but after purification and detection, the product is a selenide amide product with two benzene rings, which is then subjected to hydrothermal treatment. The vaporization temperature of Se known in the art is about 217°C (at one atmosphere), but at this temperature, carbonization or nitrogen-carbonization of organic matter cannot be achieved. Therefore, the present invention uses a hydrothermal carbonization method. Under hydrothermal conditions, carbonization of an organic carrier can be achieved at high pressure and low temperature, and the vaporization temperature of selenium increases with the hydrothermal gas pressure. As shown in general, at 10 atmospheres, the vaporization temperature of selenium is greater than 380°C. The present invention increases the pressure by pre-introducing nitrogen, and uses the relative proportion of the aqueous solution in the hydrothermal reactor to adjust the pressure to ensure that selenium will be vaporized. At the same time, attention should be paid to air or oxygen in the water to avoid the formation of selenium oxide.

[0026] Then the hydrothermal product is subjected to sulfurization and purification treatment, mainly by using different temperatures of selenium and sulfur to react and sublimate to remove sulfur. Finally, ultrasonic treatment is used in deionized water to dissolve the selenium oxide obtained in the preparation process in water to separate selenium sulfide and selenium oxide, and an inorganic anti-dandruff and antipruritic agent with a yellow-black-brown color is obtained.

[0027] In order to eliminate the influence of surfactants or complexing agents or other additive ingredients on the color of selenium sulfide, the yellow-black-brown inorganic anti-dandruff and antipruritic agent is characterized for its non-discoloration property, and the color is characterized using Lab values. For details, see the examples.

[0028] Beneficial technical effects: (1) The shampoo prepared by the present invention through the auxiliary coordination of a surfactant combination and an additive has the effects of removing dandruff, relieving itching, sterilizing, inhibiting bacteria, removing oil, being cold and heat resistant, highly stable, having low irritation to the skin, being refreshing and pleasant, and having good moisturizing and nutritional functions. In addition, it can effectively remove grease, inhibit grease secretion, regulate water-oil balance, repair the scalp barrier, maintain the homeostasis of the scalp environment, and make the scalp fresh and non-sticky for a long time; (2) The present invention proposes for the first time to use an organic selenium carrier as a raw material for an anti-dandruff agent, to control the carbonization of organic matter by hydrothermal means, and to effectively purify selenium sulfide by temperature regulation, thereby eliminating the influence of sulfur and selenium oxide, and obtaining nitrogen-hybridized carbon-based selenium disulfide, wherein the selenium sulfide is highly dispersed on the surface of the nitrogen-hybridized carbon material, with a particle size of 10-20 nm, a mass loading of ≥8.3%, and a purity of selenium sulfide of >99.99%; (3) The nitrogen-hybridized carbon-based selenium disulfide anti-dandruff agent itself has extremely high anti-discoloration property, and is more beneficial in anti-discoloration property when used in a single lotion or shampoo. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Attached Figure 1 Hair quality test chart of Comparative Example 1.

[0030] Attached Figure 2Hair quality detection diagram of Example 1. DETAILED DESCRIPTION Example 1

[0031] A highly effective oil-removing and itching-relieving shampoo is prepared from the following raw materials in the following mass ratios: 25% active substance LSA ammonium lauryl sulfate 21.31%; 70% active substance AESA ammonium lauryl polyoxyethylene ether sulfate 16.22%; Coconut oil monoethanolamide CMEA 0.93%; Octyldodecanol higher alcohol 0.82%; Pearlescent diester 1.78%; Caprylic / capric glyceride GTCC 0.23%; D50 = 15-25μm silicone oil content 50% large particle size emulsified silicone oil 4.23%; Polyquaternium-10 0.41%; 0.021% of polyethylene oxide having a number average molecular weight of more than 1 million; Citric acid 0.017%; NaH2PO4-Na2HPO4 0.18%; Sodium chloride 0.23%; Inorganic anti-dandruff and antipruritic agents 11.23%; Kaison 0.081%; Fragrance 0.59%; Silk peptide powder 0.13%; Ammonium xylenesulfonate 0.059%; Deionized water balance.

[0032] The inorganic anti-dandruff and antipruritic agent is prepared by the following method: (1) 45 mg of benzamide, 155 mg of diphenyl diselenide, 5.5 mg of triruthenium dodecacarbonyl, 7.5 mg of silver hexafluoroantimonate, 52.5 mg of anhydrous silver acetate, 4.5 ml of ethanol, and 3 ml of DMF were added to a 50 mL reaction container in sequence, and reacted at 97.5 ° C for 26 hours under an inert atmosphere. After natural cooling, 25 mL of deionized water was added, and then the organic layer was extracted with water, and then washed, dried, concentrated under reduced pressure, and silica gel column chromatography was performed to obtain a selenized organic carrier; (2) 45 mL of selenized organic carrier, 4.5 mL of formaldehyde, and 110 mL of deionized water were placed in a hydrothermal reactor. The air in the hydrothermal reactor was expelled with nitrogen in advance, and 1.5 atmospheres of nitrogen was added to the hydrothermal reactor. The nitrogen valve was closed, and the reactor was sealed. The reaction system was allowed to react at 2750°C for 4.5 hours in the hydrothermal reactor under heating conditions. After natural cooling, the reaction was filtered, washed, and taken out to obtain nitrogen-hybridized carbon-based selenide; (3) Sublimed sulfur gas is introduced into the nitrogen-hybridized carbonyl selenide, and the mixture is fully reacted at 155°C for 11 hours, cooled naturally, and taken out; (4) placing the sample prepared in step (3) in a nitrogen tube furnace and heat treating it at 122.5°C for 4.5 h; (5) After natural cooling, the mixture is placed in deionized water for ultrasonic treatment for 25 min, filtered, vacuum dried, and plastic-sealed to obtain an inorganic anti-dandruff and antipruritic agent.

[0033] Comparative Example 1, a highly effective oil-removing and antipruritic shampoo, is prepared from the following raw materials in the following mass ratios: 25% active substance LSA ammonium lauryl sulfate 21.31%; 70% active substance AESA ammonium lauryl polyoxyethylene ether sulfate 16.22%; Coconut oil monoethanolamide CMEA 0.93%; Octyldodecanol higher alcohol 0.82%; Pearlescent diester 1.78%; Caprylic / capric glyceride GTCC 0.23%; D50 = 15-25μm silicone oil content 50% large particle size emulsified silicone oil 4.23%; Polyquaternium-10 0.41%; 0.021% of polyethylene oxide having a number average molecular weight of more than 1 million; Citric acid 0.017%; NaH2PO4-Na2HPO4 0.18%; Sodium chloride 0.23%; Kaison 0.081%; Fragrance 0.59%; Silk peptide powder 0.13%; Ammonium xylenesulfonate 0.059%; Deionized water balance.

[0034] The shampoo prepared in Example 1 and Comparative Example 1 was used as a common washing product, and the hair was washed once every two days with warm water at 40°C for one month. Figure 1 and attached Figure 2It can be seen that the shampoo of the present invention has the technical effects of removing dandruff, relieving itching and eliminating redness and swelling.

[0035] In the antibacterial test and scalp oil test, the average Malassezia counts at the beginning, 14 days, 28 days, 7 days of prohibition (using conventional Pantene Silky Smooth Shampoo without anti-dandruff function), and 14 days of prohibition (using conventional Pantene Silky Smooth Shampoo without anti-dandruff function) of Example 1 were 163 / mm 2 、67pcs / mm 2 , 59±0.5 / mm 2 、63±0.5pcs / mm 2 , 72 pieces / mm 2 In comparison example 1, the average number of Malassezia in the beginning, 14 days, 28 days, and 7 days of prohibition (using regular Pantene Silk Smooth Shampoo without anti-dandruff function) was 158 / mm 2 , 142 pieces / mm 2 , 138 pieces / mm 2 , 147±0.5pcs / mm 2 , 153 pieces / mm 2 It can be seen that the shampoo prepared in Example 1 of the present invention has good antibacterial and sustained antibacterial effects.

[0036] The scalp oil was tested at the beginning, 0 hour, 4h, and 8h of Example 1, and the results were 163.5 μg / cm 2 Initial value, 21.3 μg / cm 2 , 87.4μg / cm 2 , 117.5μg / cm 2 , and after 28 days of continuous use, they were 143.2 μg / cm 2 Initial value, 22.4 μg / cm 2 48.2.6μg / cm 2 、79.8μg / cm 2 , that is, the shampoo of the present invention can effectively remove oil and inhibit oil. Example 2

[0037] The inorganic anti-dandruff and antipruritic agent consistent with Example 1 was prepared by the following method: (1) 45 mg of benzamide, 155 mg of diphenyl diselenide, 5.5 mg of triruthenium dodecacarbonyl, 7.5 mg of silver hexafluoroantimonate, 52.5 mg of anhydrous silver acetate, 4.5 ml of ethanol, and 3 ml of DMF were added to a 50 mL reaction container in sequence, and reacted at 97.5 ° C for 26 hours under an inert atmosphere. After natural cooling, 25 mL of deionized water was added, and then the organic layer was extracted with water, and then washed, dried, concentrated under reduced pressure, and silica gel column chromatography was performed to obtain a selenized organic carrier; (2) 45 mL of selenized organic carrier, 4.5 mL of formaldehyde, and 110 mL of deionized water were placed in a hydrothermal reactor. The air in the hydrothermal reactor was expelled with nitrogen in advance, and 1.5 atmospheres of nitrogen was added to the hydrothermal reactor. The nitrogen valve was closed, and the reactor was sealed. The reaction system was allowed to react at 2750°C for 4.5 hours in the hydrothermal reactor under heating conditions. After natural cooling, the reaction was filtered, washed, and taken out to obtain nitrogen-hybridized carbon-based selenide; (3) Sublimed sulfur gas is introduced into the nitrogen-hybridized carbonyl selenide, and the mixture is fully reacted at 155°C for 11 hours, cooled naturally, and taken out; (4) placing the sample prepared in step (3) in a nitrogen tube furnace and heat treating it at 122.5°C for 4.5 h; (5) After natural cooling, the mixture is placed in deionized water for ultrasonic treatment for 25 min, filtered, vacuum dried, and plastic-sealed to obtain an inorganic anti-dandruff and antipruritic agent.

[0038] The color change performance was tested: the color change was observed in a 42°C oven for 72 hours.

[0039]

[0040] Comparative Example 2 Buy selenium sulfide lotion at the drugstore.

[0041] The color change performance test was carried out: the color change was observed in a 42°C oven for 73 hours.

[0042]

[0043] As shown above, the selenium sulfide prepared by the present invention is more stable in color than the selenium disulfide lotion purchased from the pharmacy and basically does not undergo significant changes, while the selenium sulfide of Comparative Example 2 has significant color changes and is not easy to store.

[0044] The inorganic anti-dandruff agent of the present invention is used for preparing a separate lotion, which comprises the following raw materials in mass proportions: 7 parts of LSA ammonium lauryl sulfate with 25% active substance, 3 parts of AESA ammonium lauryl polyoxyethylene ether sulfate with 70% active substance, 60 parts of octadecyl alcohol, 100 parts of inorganic anti-dandruff and antipruritic agent, 150 parts of titanium oxide, 50 parts of talc, 30 parts of monoglyceride, 20 parts of lanolin, 50 parts of glycerin, 5 parts of citric acid, and distilled water added to 1000 parts.

[0045] The method comprises the following steps: dispersing ammonium lauryl sulfate and ammonium lauryl polyoxyethylene ether sulfate with purified water, heating while stirring until dissolved; heating to 80°C, sequentially adding octadecyl alcohol, monoglyceride, lanolin, glycerin and citric acid until completely dissolved, and stirring evenly; cooling to 60°C, mixing an inorganic anti-dandruff and antipruritic agent, titanium oxide and talcum powder, adding them after effective dispersion with a homogenizer, stirring evenly, filtering the material, and obtaining an anti-dandruff shampoo lotion.

[0046] The anti-dandruff shampoo is used in combination with shampoos of other brands, and the volume ratio of the shampoo of other brands to the anti-dandruff shampoo is 1:0.1.

[0047] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A highly effective oil-removing and itching-relieving shampoo, characterized in that It is prepared from the following raw materials in the following mass ratio: 25% active substance LSA ammonium lauryl sulfate 21.31%; 70% active substance AESA ammonium lauryl polyoxyethylene ether sulfate 16.22%; Coconut oil monoethanolamide CMEA 0.93%; Octyldodecanol higher alcohol 0.82%; Pearlescent diester 1.78%; Caprylic / capric glyceride GTCC 0.23%; Silicone oil content 50% large particle size emulsified silicone oil 4.23%; Polyquaternium-10 0.41%; 0.021% of polyethylene oxide having a number average molecular weight of more than 1 million; Citric acid 0.017%; NaH2PO4-Na2HPO4 0.18%; Sodium chloride 0.23%; Inorganic anti-dandruff and antipruritic agents 8-12%; Kaison 0.081%; Fragrance 0.59%; Silk peptide powder 0.13%; Ammonium xylenesulfonate 0.059%; Deionized water balance.

2. A highly effective oil-removing and antipruritic shampoo as claimed in claim 1, characterized in that The particle size range of large particle size emulsified silicone oil is D50=15-25μm.

3. The highly effective oil-removing and antipruritic shampoo according to claim 1, characterized in that The inorganic anti-dandruff and antipruritic agent is nitrogen-mixed carbon-based selenium disulfide. The selenium sulfide is highly dispersed on the surface of the nitrogen-mixed carbon material, with a particle size of 10-20 nm and a mass loading of ≥8.3%.

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