Composition capable of rapidly activating barrier and repairing as well as application and cosmetics thereof

Abstract

The invention belongs to the technical field of cosmetic production, and discloses a rapid activation barrier repair composition, which is a mixture of D-ribose or ribonucleic acid and Ectoine, the mass ratio of the D-ribose or ribonucleic acid to Ectoine is (20-40): (12-25), and the mass ratio of the D-ribose or ribonucleic acid to Ectoine is (20-40): (12-25). According to the scheme, the RNA and the Ectoine jointly promote proliferation and migration of cells and accelerate repair of the skin barrier, the RNA promotes proliferation and migration of fibroblasts, the Ectoine promotes repair and regeneration of the cells, and the RNA and the Ectoine have a synergistic effect, so that the repair speed of the skin barrier can be further increased.

Description

Technical Field

[0001] The present application relates to the technical field of cosmetic production, and in particular to a fast-activating barrier repair composition and its application and cosmetics. Background Art

[0002] Skin barrier capacity and repair speed are the core elements of skin health. Together, they determine the skin's ability to defend against the external environment and its self-repair efficiency, which in turn has a profound impact on human health. As the largest organ in the human body, the skin is not only the first line of defense for the body, but also has the important functions of regulating body temperature, preventing water loss, and resisting the invasion of pathogens and harmful substances. Therefore, the skin barrier capacity and repair speed are of great significance to maintaining skin health and overall physical health.

[0003] First of all, the skin barrier capacity refers to the skin's defense function against external aggression. A healthy skin barrier is composed of stratum corneum, lipids and natural moisturizing factors, which can effectively block the invasion of bacteria, viruses, allergens and harmful chemicals. This barrier function not only protects the body from the threat of infection and inflammation, but also prevents excessive evaporation of water and maintains the skin's moisturizing state. If the skin barrier capacity is weakened, external harmful substances are more likely to penetrate the skin, causing allergies, inflammation and even infection; secondly, the repair speed of the skin barrier refers to the efficiency of the skin's self-repair after damage. In daily life, the skin is inevitably affected by factors such as physical friction, ultraviolet radiation, chemical stimulation and environmental pollution, resulting in temporary damage to the barrier function. If the skin can repair quickly, it can restore its defense function in a short time and reduce further damage to the skin from external aggression. In addition, rapid repair can also reduce the loss of skin moisture and maintain the skin's moisturizing ability. A healthy skin barrier can lock in moisture, prevent dryness, desquamation and itching, thereby keeping the skin soft and elastic. If the repair speed is too slow, the skin may be in a fragile state for a long time, leading to chronic skin problems such as eczema and dermatitis. What’s more serious is that slow repair may make the skin more vulnerable to external environmental damage, forming a vicious cycle and further weakening the barrier function.

[0004] There is a close connection between skin barrier capacity and repair speed. Strong barrier capacity can reduce the frequency and extent of skin damage, while fast repair speed can restore barrier function in time to prevent the problem from getting worse. For example, when the skin barrier is damaged by ultraviolet radiation, strong barrier capacity can reduce the damage of ultraviolet radiation, while fast repair speed can quickly repair damaged cells and lipid layers and restore the skin's defense function. The two complement each other and work together to maintain the health of the skin.

[0005] Chinese patent application 202410920115.6 discloses a traditional Chinese medicine composition for treating hormonal dermatitis and a preparation method thereof. The raw materials include, by weight: 3-12 parts of Scutellaria baicalensis, 6-10 parts of Taraxacum herb, 6-15 parts of Honeysuckle, 3-15 parts of Paeonia suffruticosa, 6-10 parts of Phellodendron amurense, 3-15 parts of Rhubarb, 6-10 parts of Gardenia jasminoides, 5-10 parts of Poria cocos, 9-15 parts of Plantago, 0.2-2 parts of Alum, 5-10 parts of Ectoin, 3-9 parts of ceramide, 6-12 parts of fibronectin, and 2-10 parts of schizophyllan.

[0006] Further observation of paragraph 22 of the description of the scheme shows that the scheme states: "The chemical name of Ecdoin is tetrahydromethylpyrimidine carboxylic acid, which is a major osmotic pressure compensating solute in most moderately halophilic bacteria. Ecdoin exhibits strong electronegativity with its unique ring structure, making it easy to form hydrogen bonds with water molecules, thereby prompting water molecules to arrange in an orderly manner around it. This property allows Ecdoin to connect with biological macromolecules such as proteins in the form of hydrogen bonds at the dehydrated site during the treatment of irritant dermatitis, forming a new protective film to replace its original water film, protecting the hydrogen bond position from being directly exposed to the surrounding environment, so that the biological macromolecules can still maintain their natural structure and functional characteristics under water-deficient conditions, thereby protecting key biological macromolecules such as enzymes and DNA and cell membrane structures."

[0007] It can be seen that the ectoine in this regimen has been proven to have a certain ability to repair the skin barrier during the treatment of dermatitis.

[0008] Chinese patent application 202311350319.2 discloses a repair and anti-aging preparation containing RNA extract stock solution and a preparation method, comprising: mRNA messenger RNA, biological polypeptides, plant extracts, mixed polysaccharides, L-carnitine, soy isoflavones, bromelain, lecithin, ceramide-3, niacinamide, visnadin, and the balance is purified water;

[0009] Further observation of the instructions for the plan shows that the ribonucleic acid in the plan is specifically mRNA messenger ribonucleic acid, which can accelerate cell regeneration, promote cell reticular fiber formation, inhibit inflammatory factors, and restore healthy and beautiful skin; it can be seen that ribonucleic acid has certain repair capabilities.

[0010] In summary, the existing technology has disclosed the barrier capacity of Ecdoin and the repair capacity of RNA to a certain extent, but the existing technology has not conducted much discussion and verification on whether there is a synergistic effect between the two.

[0011] The problem to be solved in this scheme is: how to provide a composition with good barrier repair ability. Summary of the invention

[0012] The purpose of the present application is to provide a composition with barrier repair ability. The composition, through the cooperation between ribonucleic acid or D-ribose and ectoine, on the one hand improves the barrier ability of the skin itself and reduces the exchange between the skin and harmful substances in the outside world; on the other hand, it improves the barrier repair ability of the skin, so that the skin barrier can be quickly repaired after being damaged.

[0013] To achieve the above objectives, the present application discloses a rapidly activated barrier repair composition, which is a mixture of D-ribose or ribonucleic acid and ectoine, and the mass ratio of D-ribose or ribonucleic acid to ectoine is 20-40:12-25.

[0014] The ribonucleic acid (RNA) in this case can guide cells to synthesize proteins needed for repair, promote the renewal and regeneration of epidermal cells, and accelerate the repair of damaged barriers. In addition, ribonucleic acid plays an important role in the regulation of gene expression and can activate genes related to skin barrier repair, such as lipid synthase, antioxidant enzymes, etc.

[0015] At the same time, RNA can also regulate the expression of genes related to lipid synthesis, promote the production of lipids such as ceramide, cholesterol and free fatty acids, repair the stratum corneum lipid barrier, enhance the skin's ability to lock in moisture and its resistance to external stimuli, and the metabolites of RNA (such as D-ribose) are precursors of ATP (adenosine triphosphate), which provides energy for skin cells and supports cell repair and regeneration. Adequate ATP supply helps accelerate the recovery of barrier function, and by supporting energy metabolism, RNA can enhance the vitality of skin cells and promote the long-term maintenance of barrier function.

[0016] Ecdoin interacts with lipids and proteins on the cell membrane to stabilize the cell membrane structure and enhance its resistance to external stimuli (such as ultraviolet rays, pollutants, dryness, etc.). Ecdoin can promote the orderly arrangement of stratum corneum lipids and enhance the tightness of the stratum corneum, thereby improving the water-locking ability and protective function of the skin barrier.

[0017] In addition, Ecdoin can enhance the self-repair ability of skin cells and accelerate the recovery of damaged barriers. In addition, Ecdoin can prevent denaturation or damage due to external stimuli (such as ultraviolet rays, high temperature, etc.) by binding to proteins and DNA, thereby protecting the normal function of skin cells.

[0018] Preferably, the rapid activation barrier repair composition further contains schizophyllanthus, and the mass ratio of the D-ribose or ribonucleic acid to ectoine and schizophyllanthus is 20-40:12-25:40-60.

[0019] Furthermore, schizophyllan can form a breathable protective film on the skin surface to prevent moisture loss and resist external stimuli (such as pollutants, ultraviolet rays, etc.), thereby enhancing the skin barrier function. Schizophyllan can also promote the orderly arrangement of stratum corneum lipids, enhance the tightness of the stratum corneum, and enhance the barrier's water-locking ability and protective function. Moreover, schizophyllan can also promote the proliferation and differentiation of epidermal cells and accelerate the repair process of damaged barriers. In addition, schizophyllan can also enhance the vitality of skin cells by supporting cell metabolism and promote the long-term maintenance of barrier function.

[0020] Preferably, the rapid activation barrier repair composition is a mixture of ribonucleic acid, ectoine and schizophylline, and the mass ratio of ribonucleic acid to ectoine and schizophylline is 20-40:12-25:40-60.

[0021] In addition, the present application also discloses the use of the above-mentioned rapid activation barrier repair composition for preparing cosmetics.

[0022] In addition, the present application also discloses a cosmetic containing 1 to 20 wt % of the above-mentioned rapid activation barrier repair composition.

[0023] Preferably, the cosmetic is in the form of a patch, ointment, liquid, spray, gel, emulsion or cream.

[0024] Preferably, the cosmetic is a gel, an essence, a toner, a facial mask, a cleanser, a lotion, a perfume, a makeup remover, a lipstick, a blush or a spray.

[0025] The beneficial effects of this application are:

[0026] The ribonucleic acid (RNA) in this case can guide cells to synthesize proteins needed for repair, promote the renewal and regeneration of epidermal cells, and accelerate the repair of damaged barriers. In addition, ribonucleic acid plays an important role in the regulation of gene expression and can activate genes related to skin barrier repair, such as lipid synthase, antioxidant enzymes, etc.

[0027] At the same time, RNA can also regulate the expression of genes related to lipid synthesis, promote the production of lipids such as ceramide, cholesterol and free fatty acids, repair the stratum corneum lipid barrier, enhance the skin's ability to lock in moisture and its resistance to external stimuli, and the metabolites of RNA (such as D-ribose) are precursors of ATP (adenosine triphosphate), which provides energy for skin cells and supports cell repair and regeneration. Adequate ATP supply helps accelerate the recovery of barrier function, and by supporting energy metabolism, RNA can enhance the vitality of skin cells and promote the long-term maintenance of barrier function.

[0028] Ecdoin interacts with lipids and proteins on the cell membrane to stabilize the cell membrane structure and enhance its resistance to external stimuli (such as ultraviolet rays, pollutants, dryness, etc.). Ecdoin can promote the orderly arrangement of stratum corneum lipids and enhance the tightness of the stratum corneum, thereby improving the water-locking ability and protective function of the skin barrier.

[0029] In addition, Ecdoin can enhance the self-repair ability of skin cells and accelerate the recovery of damaged barriers. In addition, Ecdoin can prevent denaturation or damage due to external stimuli (such as ultraviolet rays, high temperature, etc.) by binding to proteins and DNA, thereby protecting the normal function of skin cells.

[0030] RNA and Ecdoin work together to promote cell proliferation and migration, accelerating the repair of the skin barrier. RNA promotes the proliferation and migration of fibroblasts, and Ecdoin promotes the repair and regeneration of cells. The synergistic effect of the two can further increase the speed of skin barrier repair. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 This is the fluorescence image of the blank control group during the zebrafish embryo skin barrier permeability inhibition test;

[0032] Figure 2 This is the fluorescence image of the model control group during the zebrafish embryo skin barrier permeability inhibition test;

[0033] Figure 3 This is a fluorescence image of the sample group prepared in Example 2 during the zebrafish embryo skin barrier permeability inhibition rate test;

[0034] Figure 4 This is a schematic diagram of the model control group during the test of the zebrafish embryo tail fin repair promotion rate;

[0035] Figure 5 Schematic diagram of the sample group prepared in Example 2 during the test of the zebrafish embryo tail fin repair promotion rate. DETAILED DESCRIPTION

[0036] The present invention will be described clearly and completely below in conjunction with the embodiments of the present invention. In the description of the present invention, it should be noted that, if no specific conditions are specified in the embodiments, the conditions are carried out according to conventional conditions or conditions recommended by the manufacturer. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased commercially.

[0037] Before presenting the examples, the following necessary explanations are given on the preparation and acquisition methods of the raw materials involved in the examples:

[0038] D-ribose: RIBOXYL from LUCAS MEYER COSMETICS SAS TM , effective substance content 100%

[0039] RNA: Yeast extract N80 (N) purchased from Angel Yeast Co., Ltd., with an active substance content of 3.5%

[0040] Ecdoin: XE-03 purchased from Shanghai Xuntian Biotechnology Co., Ltd., with an active substance content of 100%; Schizophyllan: purchased from Zhejiang Lien Biotechnology Co., Ltd. BA-2005C, active substance content 0.5%

[0041] The preparation method of the fast-activated barrier repair composition is as follows: D-ribose or ribonucleic acid and ectoine are accurately weighed in sequence, and then added into a reaction kettle, stirred and mixed evenly, allowed to stand, and filtered to obtain the target product;

[0042] In addition, it should be noted that when using D-ribose to prepare a rapid-activation barrier repair composition, D-ribose should be dispersed in advance using pure water to form a D-ribose aqueous solution with a mass fraction of D-ribose of 25±2% for use, so as to improve the dispersibility of the rapid-activation barrier repair composition.

[0043] Unless otherwise specified, the remaining examples and comparative examples all adopt this method to prepare the rapid activation barrier repair composition.

[0044] Examples 1-7

[0045] A fast-activating barrier repair composition, the raw materials and the quality ratios between the raw materials are shown in Table 1:

[0046] Table 1

[0047]

[0048]

[0049] Comparative Examples 1-9

[0050] A composition, raw materials and the quality ratios between the raw materials are shown in Table 2:

[0051] Table 2

[0052]

[0053] Performance Test:

[0054] 1. Zebrafish embryo skin barrier permeability test

[0055] Pick healthy 3-day-post-fertilization (DPF) zebrafish embryos.

[0056] 1.1 Test Grouping

[0057] The test set up a blank control group (fish embryo culture medium), a model control group (fish embryo culture medium) and a test substance group (the composition prepared in the embodiment and the comparative example was diluted with pure water to an aqueous solution with a mass fraction of 8%).

[0058] 1.1.1 Blank control group setting

[0059] Randomly select 6 fish embryos and place them in a 6-well plate, and add 6 mL of fish embryo culture medium.

[0060] 1.1.2 Model control group setting

[0061] Randomly select 6 fish embryos and place them in a 6-well plate, and add 6 mL of fish embryo culture medium.

[0062] 1.1.3 Test article treatment

[0063] 96 fish embryos were randomly selected and placed in a 6-well plate, and 6 mL of the test substance solution was added.

[0064] After culturing at 28℃±1℃ for 1h±0.1h, the blank control group was replaced with 6mL of new fish embryo culture medium, and the other groups were replaced with 6mL of the respective treatment group solution containing 0.05g / L SDS and placed at 28℃±1℃ for 40min. The fish embryos were washed 3 times and then stained with 1g / L sodium fluorescein solution for 30min.

[0065] 1.2 Microscopic analysis of samples

[0066] The fish embryos were washed twice with fish embryo culture medium, and then placed sideways. The fish embryos were photographed under a fluorescent stereo microscope according to uniform photographic parameters.

[0067] 1.3 Data and result calculation

[0068] Open the photo with analysis software such as Image J, mark the tail fin area of ​​each fish embryo, then select "Measure Average Intensity" in the "Measurement" column, and select the "Average Signal Intensity" in the test results as the fluorescence intensity.

[0069] The calculation formula of skin barrier permeability inhibition rate is shown in formula 1:

[0070]

[0071] In formula 1:

[0072] S is the average fluorescence intensity of the tail fin of fish embryos in the test substance treatment group;

[0073] M is the average fluorescence intensity of the caudal fin of fish embryos in the model control group;

[0074] B is the average fluorescence intensity of the caudal fin of fish embryos in the blank control group;

[0075] The data were analyzed by variance analysis using statistical software, and the fluorescence intensity of the caudal fin between the test group and the model control group was tested by two-tailed T test to obtain the P value. P<0.05 indicated a significant difference.

[0076] The test results are shown in Table 3:

[0077] Table 3

[0078]

[0079] Result analysis:

[0080] 1. Combine Table 3 and refer to Figure 1-3 It can be seen from Examples 1-3 that when the mass ratio between RNA and Ecdoin is slightly adjusted, the difference in the ability of Examples 1-3 to inhibit skin barrier permeability is small. It can be seen that when the mass ratio between RNA and Ecdoin is slightly adjusted, the difference in the effect of the composition on the barrier ability of the skin is small;

[0081] At the same time, it can be seen from comparative examples 1 and 2 that when RNA or Ecdoin is used alone, the skin barrier permeation inhibition rates of comparative examples 1 and 2 are only 73.23% and 72.31%, respectively. Therefore, the theoretical value of Example 2 should be approximately: 73.23% × 18 / 48 + 72.31% × 30 / 48 = 75.65%;

[0082] However, the actual value of Example 2 reached 84.03%, which shows that there is a certain synergistic effect between RNA and Ecdoin, which further improves the barrier ability of the skin;

[0083] 2. It can be seen from Examples 1 and 5-7 that when schizophyllanthus is added to the composition, Examples 5-7 have a more significant improvement in the barrier ability of the skin; at the same time, it can be seen from Comparative Examples 3 and 4 that when RNA is used together with schizophyllanthus or ectoine is used together with schizophyllanthus, the skin barrier ability of Comparative Examples 3-4 is equivalent to that of Comparative Examples 1 and 2, or even slightly lower than that of Comparative Examples 1 and 2. It can be inferred that the effect of schizophyllanthus itself on improving the barrier ability should be slightly inferior to that of RNA and ectoine;

[0084] However, when schizophyllanthus was added to the mixed system of RNA and ectoine, the skin barrier permeation inhibition rate of Example 6 reached 89.50%. It can be seen that on the one hand, schizophyllanthus can produce further synergistic effects with RNA and ectoine;

[0085] On the other hand, the above synergistic effect can only be fully exerted when RNA and Ecdoin are present at the same time;

[0086] 3. It can be seen from Example 2 and Comparative Examples 5-6 that Comparative Examples 5-6 and Comparative Examples 3-4 have comparable skin barrier enhancement capabilities, but further observation of Comparative Examples 7-8 shows that when schizophyllanthic acid is added to a system where deoxyribonucleic acid and ectoine coexist or a system where ribonucleic acid and betaine coexist, the skin barrier permeability inhibition rate of Comparative Examples 7-8 is not significantly improved compared to Comparative Examples 5-6. It can be seen that, on the one hand, deoxyribonucleic acid and ectoine cannot produce a synergistic effect, and ribonucleic acid and betaine cannot produce a synergistic effect;

[0087] On the other hand, schizophyllan cannot play a promoting role in the system where DNA and ectoine coexist or in the system where RNA and betaine coexist.

[0088] 2. Test on the repair promotion rate of zebrafish embryo tail fin

[0089] Pick healthy 3-day-post-fertilization (DPF) zebrafish embryos.

[0090] 2.1 Damage model

[0091] The zebrafish embryos were anesthetized with tricaine solution, and the tail fins of the zebrafish embryos were removed with a laboratory scalpel under a microscope.

[0092] 2.2 Test Grouping

[0093] The test set up a blank control group (normal zebrafish embryos without tail cut in fish embryo culture medium), a model control group (fish embryo culture medium) and a test substance group (the composition of the embodiment and the comparative example was diluted with pure water to an aqueous solution with a mass fraction of 8%).

[0094] 2.2.1 Blank control group setting

[0095] Six normal fish embryos without tail chops were randomly selected and placed in a 96-well plate, with each well containing one fish embryo and 0.2 mL of fish embryo culture medium.

[0096] 2.2.2 Model control group setting

[0097] Six tail-cut fish embryos were randomly selected and placed in a 96-well plate, with each well containing one fish embryo and 0.2 mL of fish embryo culture medium.

[0098] 2.2.3 Test substance treatment group setting

[0099] Randomly select 96 tail-cut fish embryos and place them in a 96-well plate, with each well containing one fish embryo and 0.2 mL of the test substance solution. Place in a 28℃±1℃ incubator and culture for 72h±1h.

[0100] 2.3 Microscopic analysis of samples

[0101] The zebrafish were anesthetized with tricaine and placed under a stereomicroscope at 48h and 72h of culture to take side photos of the tail of the fish embryo.

[0102] 2.4 Data and result calculation

[0103] Count the length of the caudal fin of each fish embryo

[0104] The calculation method for the tail fin repair promotion rate is shown in Formula 2:

[0105]

[0106] In formula 2:

[0107] S is the average tail fin length of fish embryos in the test substance treatment group;

[0108] M is the average tail fin length of fish embryos in the model control group;

[0109] B is the average tail fin length of fish embryos in the blank control group;

[0110] The data were analyzed by variance analysis using statistical software, and the tail fin length between the test group and the model control group was tested by two-tailed T test to obtain the p value. p<0.05 indicated a significant difference.

[0111] The test results of the 48h tail fin repair promotion rate are shown in Table 4:

[0112] Table 4

[0113]

[0114] The test results of the 72h tail fin repair promotion rate are shown in Table 5:

[0115] Table 5

[0116]

[0117] Result analysis:

[0118] 1. Combine Table 4 and refer to Figure 4-5 ,,It can be seen from Examples 1-3 that when the mass ratio between RNA and Ecdoin is slightly adjusted, the difference in the ability of Examples 1-3 to promote skin repair is small. It can be seen that when the mass ratio between RNA and Ecdoin is slightly adjusted, the difference in the effect of the composition on the ability to promote skin repair is small;

[0119] At the same time, it can be seen from comparative examples 1 and 2 that when RNA or Ecdoin is used alone, the tail fin repair promotion rates of comparative examples 1 and 2 are only 5.84% and 5.92%, respectively. Therefore, the theoretical value of Example 2 should be approximately: 5.84% × 18 / 48 + 5.92% × 30 / 48 = 5.89%;

[0120] However, the actual value of Example 2 reached 9.93%, which shows that a certain synergistic effect was produced between RNA and Ecdoin, which further enhanced the ability of the composition to promote skin repair;

[0121] 2. It can be seen from Examples 1 and 5-7 that when schizophyllanthus is added to the composition, Examples 5-7 have a more significant improvement in the ability to promote skin repair; at the same time, it can be seen from Comparative Examples 3 and 4 that when RNA is used together with schizophyllanthus or ectoine is used together with schizophyllanthus, the skin repair ability of Comparative Examples 3-4 is equivalent to that of Comparative Examples 1 and 2. It can be inferred that the effect of schizophyllanthus on promoting skin repair should be equivalent to that of RNA and ectoine;

[0122] However, when schizophyllanthus was added to the mixed system of RNA and Ectoin, the tail fin repair promotion rate of Example 6 reached 13.05%. It can be seen that, on the one hand, schizophyllanthus can produce further synergistic effects with RNA and Ectoin;

[0123] On the other hand, the above synergistic effect can only be fully exerted when RNA and Ecdoin are present at the same time;

[0124] 3. It can be seen from Example 2 and Comparative Examples 5-6 that the ability of Comparative Examples 5-6 to promote skin repair is equivalent to that of Comparative Examples 3-4. However, further observation of Comparative Examples 7-8 shows that when schizophyllanthus acid is added to the system where deoxyribonucleic acid and ectoine coexist or the system where ribonucleic acid and betaine coexist, the tail fin repair promotion rate of Comparative Examples 7-8 is not significantly improved compared with Comparative Examples 5-6. It can be seen that, on the one hand, deoxyribonucleic acid and ectoine cannot produce a synergistic effect, and ribonucleic acid and betaine cannot produce a synergistic effect;

[0125] On the other hand, schizophyllan cannot play a promoting role in the system where DNA and ectoine coexist or in the system where RNA and betaine coexist;

[0126] Further, in combination with Table 5, it can be seen that, taking Example 2 as an example, in the first 48 hours, the average hourly promotion rate of tail fin repair is about 0.21%, and when the duration is extended to 72 hours, the average hourly promotion rate of tail fin repair decays to 0.17%. It can be seen that Example 2 shows a more significant promotion trend in the skin repair ability in the first 48 hours of use. As the use time is extended to 72 hours, although it still shows an improvement effect, the efficiency shows a more obvious decay trend;

[0127] At the same time, by observing Comparative Example 1 and Comparative Example 2, it can be seen that the tail fin repair promotion rates of both in the first 48 hours were about 0.12% and 0.12% per hour. At 72 hours, the average tail fin repair promotion rates per hour were 0.11% and 0.12%. It can be seen that both can promote the repair in the first 48 hours, but the efficiency is not high. At the same time, as time goes by, the efficiency does not show a significant change. It can be seen that compared with Example 2, Comparative Examples 1 and 2 cannot quickly promote skin repair in a short time;

[0128] It can be seen that when RNA and Ecdoin are mixed together, the composition can show a better effect on improving skin repair ability in a short period of time.

Claims

1. A fast-activating barrier repair composition, characterized in that: The fast-activating barrier repair composition is a mixture of D-ribose or ribonucleic acid and ectoine, and the mass ratio of the D-ribose or ribonucleic acid to ectoine is 20-40:12-25.

2. The fast-activating barrier repair composition according to claim 1, characterized in that: The fast-activation barrier repair composition also contains schizophyllanthus, and the mass ratio of the D-ribose or ribonucleic acid to ectoine and schizophyllanthus is 20-40:12-25:40-60.

3. The fast-activating barrier repair composition according to claim 1, characterized in that: The fast-activation barrier repair composition is a mixture of ribonucleic acid, ectoine and schizophylline, and the mass ratio of ribonucleic acid to ectoine and schizophylline is 20-40:12-25:40-60.

4. Use of the fast-activating barrier repair composition according to any one of claims 1 to 3 in preparing cosmetics.

5. A cosmetic, characterized in that: Contains 1-20 wt % of the fast-activating barrier repair composition as claimed in any one of claims 1-3.

6. The cosmetic according to claim 5, characterized in that: The dosage form of the cosmetic is a patch, ointment, liquid, spray, gel, emulsion or cream.

7. The cosmetic according to claim 5, characterized in that: The cosmetics are gel, essence, toner, facial mask, cleanser, lotion, perfume, make-up remover, lipstick, blush or spray.

Images