Anti-hair-loss, oil-control and anti-dandruff shampoo and preparation method thereof

Abstract

The invention belongs to the technical field of daily cosmetics, and particularly relates to anti-hair-loss, oil-control and anti-dandruff shampoo and a preparation method thereof. The hair loss preventing, oil controlling and dandruff removing composition of the shampoo is used as a main active matter and comprises caffeine, glycoprotein, a tea extract, capryloyl glycine, PCA zinc, piroctone olamine and a purslane herb extract, the three effects of hair loss preventing, oil controlling and dandruff removing are integrated, the problems of hair loss, oil outlet and dandruff removing are comprehensively solved, and the economic practicability is improved.

Description

Technical Field

[0001] The invention belongs to the technical field of daily cosmetics, and in particular relates to an anti-hair loss, oil-controlling and anti-dandruff shampoo and a preparation method thereof. Background Art

[0002] The scalp is the "soil" for hair growth. The scalp environment is complex, and its health directly affects the quality of hair. Modern people have frequent scalp problems due to stressful life, irregular work and rest schedules, and unbalanced diets, such as excessive oil secretion, dandruff, and clogged hair follicles. These problems are interrelated and affect each other, and it is difficult for a single-effect shampoo to fully solve them.

[0003] In order to meet the needs of scalp health and hair care and provide better comprehensive conditioning effects, it is particularly important for shampoo to treat multiple problems of scalp and hair at the same time. For example, oil-control ingredients can regulate scalp oil secretion, reduce oil accumulation, and create a refreshing growth environment for hair; anti-dandruff ingredients can effectively remove dandruff, relieve scalp itching, and keep the scalp clean; anti-hair loss ingredients help improve scalp microcirculation, provide nutrition for hair follicles, and reduce the occurrence of hair loss, thereby comprehensively improving the health of the scalp and creating a good foundation for hair growth. By solving scalp and hair problems, hair can look more refreshing, clean, and fluffy, enhance the gloss and elasticity of hair, and improve the overall hair quality and image.

[0004] From the perspective of economic practicality, a shampoo that combines the three effects of hair loss prevention, oil control, and dandruff removal can reduce the damage to the scalp caused by frequent use of shampoos with a single effect. One bottle of shampoo can solve a variety of scalp and hair problems and comprehensively improve the condition of the scalp and hair, which is equivalent to buying multiple bottles of shampoos with different effects at the same time, reducing the number of times that the problem needs to be frequently replaced or other cleaning products need to be purchased due to recurring problems, and to a certain extent reducing the long-term cleaning cost. From the perspective of its comprehensive efficacy and long-term use effect, the cost-effectiveness is relatively high. Therefore, it is very important to provide a shampoo that combines the three effects of hair loss prevention, oil control, and dandruff removal. Summary of the invention

[0005] The invention provides an anti-hair loss, oil control and anti-dandruff composition, comprising: caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt and purslane extract.

[0006] Preferably, the mass ratio of caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, and purslane extract is (0-3):(0-9):(0-3.5):(0-2.5):(0-0.6):(0-0.5):(0-8).

[0007] Preferably, the mass ratio of caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, and purslane extract is (0.5-2.5):(1-7):(0.5-3):(0.4-2.5):(0.01-0.5):(0.05-0.45):(0.8-6.5).

[0008] Preferably, the mass ratio of caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, and purslane extract is (0.8-2):(3-6):(1-2.5):(0.7-1.6):(0.1-0.3):(0.2-0.4):(2-5).

[0009] The invention provides an application of an anti-hair loss, oil control and anti-dandruff composition in preparing an anti-hair loss, oil control and anti-dandruff shampoo. The anti-hair loss, oil control and anti-dandruff composition comprises: caffeine, glycoprotein, tea extract, capryloyl glycine, PC A zinc, piroctone olamine salt and purslane extract.

[0010] Preferably, an anti-hair loss, oil control and anti-dandruff composition is used in the preparation of an anti-hair loss, oil control and anti-dandruff shampoo, wherein the anti-hair loss, oil control and anti-dandruff composition comprises caffeine, glycoprotein, tea extract, capryloylglycine, PCA zinc, piroctone olamine salt and purslane extract in a mass ratio of (0.5-2.5):(1-7):(0.5-3):(0.4-2.5):(0.01-0.5):(0.05-0.45):(0.8-6.5).

[0011] Preferably, an anti-hair loss, oil control and anti-dandruff composition is used in the preparation of an anti-hair loss, oil control and anti-dandruff shampoo, wherein the anti-hair loss, oil control and anti-dandruff composition comprises caffeine, glycoprotein, tea extract, capryloylglycine, PCA zinc, piroctone olamine salt and purslane extract in a mass ratio of (0.8-2):(3-6):(1-2.5):(0.7-1.6):(0.1-0.3):(0.2-0.4):(2-5).

[0012] The invention provides a method for preparing an anti-hair loss, oil control and anti-dandruff composition, comprising: weighing caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt and purslane extract according to mass ratio, and mixing them evenly to obtain the composition.

[0013] Preferably, a method for preparing an anti-hair loss, oil control and anti-dandruff composition comprises: weighing caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, and purslane extract in a mass ratio of (0.5-2.5):(1-7):(0.5-3):(0.4-2.5):(0.01-0.5):(0.05-0.45):(0.8-6.5), mixing well, and obtaining the composition.

[0014] Preferably, a method for preparing an anti-hair loss, oil control and anti-dandruff composition comprises: weighing caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, and purslane extract in a mass ratio of (0.8-2):(3-6):(1-2.5):(0.7-1.6):(0.1-0.3):(0.2-0.4):(2-5), mixing well, and obtaining the composition.

[0015] The invention provides an anti-hair loss, oil-control and anti-dandruff shampoo, comprising an anti-hair loss, oil-control and anti-dandruff composition, a surfactant, a moisturizer, an antioxidant, an essence, a pigment and purified water.

[0016] Preferably, the composition comprises, by mass percentage: 3.26-22.45% of the anti-hair loss, oil control and anti-dandruff composition, 1-20% of a surfactant, 1-15% of a moisturizer, 0.02-0.2% of an antioxidant, 0-0.1% of an essence, 0-0.1% of a pigment, and the remainder of purified water.

[0017] Preferably, the composition comprises, by mass percentage: 7.8-17.8% of the anti-hair loss, oil control and anti-dandruff composition, 9-18% of a surfactant, 6-14% of a moisturizer, 0.05-0.1% of an antioxidant, 0-0.03% of an essence, 0-0.01% of a pigment, and the remainder of purified water.

[0018] The surfactant is selected from at least one of sodium laureth sulfate, sodium cocoyl glutamate, sodium cocoyl alanine, sodium lauroyl sarcosinate, sodium lauroyl aspartate, cocamidopropyl betaine, lauroyl amidopropyl betaine, cocamide monoethanolamine, sodium lauryl glucoside carboxylate, sodium lauryl ether sulfate, sodium methyl cocoyl taurate, sodium lauryl sulfoacetate, disodium lauryl sulfosuccinate, sodium lauroyl hydroxymethyl sulfonate, sodium lauroyl hydroxyethyl sulfonate, sodium lauroyl amphoacetate, coconut glucoside, lauryl glucoside, and coconut methyl glucose amide.

[0019] The moisturizer is selected from at least one of glycerin, propylene glycol, butylene glycol, pentylene glycol, hyaluronic acid, lactic acid, sodium lactate, urea, sorbitol, trehalose, sclerotium gum, vaseline, white mineral oil, squalane, panthenol, aloe extract, and ceramide.

[0020] The antioxidant is selected from at least one of benzyl alcohol, phenoxyethanol, methylparaben, ethylparaben and ethylhexylglycerin.

[0021] The present invention provides a method for preparing an anti-hair loss, oil-controlling and anti-dandruff shampoo, comprising:

[0022] S1, taking each raw material according to mass percentage;

[0023] S2. Add the moisturizer to purified water, heat to 40-60°C, mix well, and keep warm for later use;

[0024] S3, heat the surfactant to 65-86°C, mix well, cool to 30-50°C, and keep warm for later use;

[0025] S4. Slowly add the material of step S3 to the material of step S2, mix at 30-50° C., then add the anti-hair loss, oil control and anti-dandruff composition, flavor, pigment and antioxidant in sequence, mix homogeneously, and obtain.

[0026] Beneficial effects of the present invention:

[0027] The anti-hair loss, oil control and anti-dandruff composition of the present invention acts precisely on the sebaceous glands, regulates the secretion function of the sebaceous glands, balances the water and oil of the scalp, fundamentally solves the problem of excessive oil secretion, and keeps the scalp in a healthy state. It contains piroctone olamine salt and tea extract ingredients, which can inhibit fungal infections on the scalp and reduce the generation of dandruff from the source. At the same time, piroctone olamine salt has excellent scalp soothing function and can effectively relieve the itching caused by scalp inflammation. It contains caffeine, glycoprotein, and tea extract ingredients, which provide sufficient nutrients for the hair, promote scalp blood circulation, create good conditions for the growth of hair, help hair growth, and make the hair thicker. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 This is a graph showing the inhibition rate of 5α-reductase.

[0029] Figure 2 This is a statistical chart of the length of new hair in mice. DETAILED DESCRIPTION

[0030] In order to more fully understand the technical content of the present invention, the present invention will be further introduced and illustrated in conjunction with specific embodiments below.

[0031] The raw materials used in the examples and comparative examples of the present invention and the reagents used in the efficacy tests are all commonly used raw materials in the art that can be purchased on the market.

[0032] Example 1

[0033] An anti-hair loss, oil control and anti-dandruff composition, comprising: caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, purslane extract;

[0034] The mass ratio of caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, and purslane extract is 0.8:3:1:0.7:0.1:0.2:2.

[0035] Example 2

[0036] An anti-hair loss, oil control and anti-dandruff composition, comprising: caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, purslane extract;

[0037] The mass ratio of caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, and purslane extract is 1:4:1.5:0.9:0.2:0.3:4.

[0038] Example 3

[0039] An anti-hair loss, oil control and anti-dandruff composition, comprising: caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, purslane extract;

[0040] The mass ratio of caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, and purslane extract is 1.4:5:2:1.2:0.2:0.3:3.5.

[0041] Example 4

[0042] An anti-hair loss, oil control and anti-dandruff composition, comprising: caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, purslane extract;

[0043] The mass ratio of caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, and purslane extract is 2:6:2.5:1.6:0.3:0.4:5.

[0044] Comparative Example 1

[0045] A composition comprising: ginger root extract, Platycladus orientalis leaf extract, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, purslane extract;

[0046] The mass ratio of ginger root extract, Platycladus orientalis leaf extract, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, and Portulaca oleracea extract is 1:4:1.5:0.9:0.2:0.3:4.

[0047] Comparative Example 2

[0048] A composition comprising: caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, salicylic acid, pyrithione zinc, purslane extract;

[0049] The mass ratio of caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, salicylic acid, pyrithione zinc, and purslane extract is 1.4:5:2:1.2:0.2:0.2:0.1:3.5.

[0050] Comparative Example 3

[0051] A composition comprising: caffeine, glycoprotein, tea extract, calendula extract, piroctone olamine salt, purslane extract;

[0052] The mass ratio of caffeine, glycoprotein, tea extract, calendula extract, piroctone olamine salt, and purslane extract is 1:4:1.5:3.5:0.3:4.

[0053] Comparative Example 4

[0054] A composition comprising: caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, purslane extract;

[0055] The mass ratio of caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, and purslane extract is 4:4:4:0.6:0.6:0.6:4.

[0056] Test Example 1: Oil control efficacy of the anti-hair loss, oil control and anti-dandruff composition

[0057] The sebaceous gland is an important gland attached to the skin and an important part of sebum production. It can secrete sebum, which enters the skin follicles and is discharged to the skin surface through the pores. Excessive activity of 5α-reductase, a catalyst for sebum synthesis in the human body, can cause the sebaceous glands to malfunction and enlarge. 5α-reductase is a membrane protease that depends on reduced coenzyme II (NADPH) and can irreversibly convert testosterone (Testosterone, T) into dihydrotestosterone (Dihydrotestosterone, DHT). This test evaluates whether the composition can inhibit the activity of 5α-reductase to judge the oil control effect of the product in alleviating excessive oil secretion from the sebaceous glands.

[0058] The compositions of Examples 1 to 4 and Comparative Examples 1 to 4 were prepared into test samples with a concentration of 50 mg / mL using a solvent, a dutasteride solution with a concentration of 2.5 mmol / L was used as a positive control, and the solvent was used as a blank control.

[0059]

[0060] Where: A sample: represents the absorbance of the sample tube;

[0061] A Sample substrate: indicates the absorbance of the sample background tube;

[0062] C: represents the absorbance of the solvent tube;

[0063] D: represents the absorbance of the solvent background tube.

[0064] Test results: The 5α-reductase inhibition rate of Examples 1 to 4 was higher than that of the blank control group and had a statistically significant difference (P<0.05), indicating that the anti-hair loss, oil-control and anti-dandruff compositions of Examples 1 to 4 have an oil-control effect. The 5α-reductase inhibition rate of Examples 1 to 4 was higher than that of Comparative Examples 1 to 4 and had a statistically significant difference (P<0.05), indicating that the oil-control effect of Examples 1 to 4 was more significant. The anti-hair loss, oil-control and anti-dandruff composition of the present invention acts precisely on the sebaceous glands, regulates the secretion function of the sebaceous glands, balances the water and oil of the scalp, fundamentally solves the problem of excessive oil secretion, and keeps the scalp in a healthy state.

[0065] Test Example 2 Anti-dandruff efficacy of the anti-hair loss, oil control and anti-dandruff composition

[0066] Dandruff is a large amount of desquamation caused by excessive proliferation of keratinocytes on the scalp, among which Malassezia is one of the important factors causing dandruff. Increased dandruff is a mild manifestation of seborrheic dermatitis of the scalp. Due to the proliferation of Malassezia, the scalp becomes oily and dandruff is severe, which in turn promotes the proliferation of Malassezia. Therefore, adding anti-dandruff agents to inhibit or kill such microorganisms has a positive effect on inhibiting the growth of dandruff: using Malassezia as an indicator bacteria, the anti-dandruff effect of the composition was tested and evaluated.

[0067] The compositions of Examples 1 to 4 and Comparative Examples 1 to 4 were prepared with solvents to prepare test samples with a concentration of 30% (m / v), a phosphate solution of Pityrosporum was used as a negative control, and a phosphate buffer was used as a blank control. Take a suspension of Pityrosporum, add it to each test sample and control sample and mix it evenly, start timing, and make appropriate dilutions when the specified action time is reached. Take 2-3 dilutions, take the test sample and the control sample and place them in two plates respectively, pour the Pityrosporum culture medium and mix evenly, turn the plate over after it solidifies, put it in an incubator and culture it for 5 to 10 days, and count the viable bacteria. See Table 1 for the test results.

[0068] Malassezia furfura inhibition rate (%) = (AB) / A×100

[0069] Where: A: average colony count of negative control sample;

[0070] B: Average colony count of test samples.

[0071] Table 1 Statistics of the antibacterial test results of Malassezia furfura

[0072]

[0073]

[0074] Test results: The antibacterial rate of Malassezia furfur in groups 1 to 4 of Examples is higher than that of the blank control group and has a statistically significant difference (P<0.05), indicating that the anti-hair loss, oil-control and anti-dandruff compositions of Examples 1 to 4 have an anti-dandruff effect. The antibacterial rate of Malassezia furfur in groups 1 to 4 of Examples is higher than that of groups 1 to 4 of Comparative Examples and has a statistically significant difference (P<0.05), indicating that the anti-dandruff effect of groups 1 to 4 of Examples is more significant. The anti-hair loss, oil-control and anti-dandruff composition of the present invention contains piroctone olamine salt and tea extract ingredients, which can inhibit fungal infections on the scalp and reduce the generation of dandruff from the source. At the same time, piroctone olamine salt has an excellent scalp soothing function, can avoid the irritation of anti-dandruff ingredients such as salicylic acid and zinc pyrithione, and can more gently and effectively remove dandruff and relieve the itching caused by scalp inflammation.

[0075] Test Example 3 Anti-hair loss effect of the anti-hair loss, oil control and anti-dandruff composition

[0076] After removing the hair on the back of the mouse with an electric shaver, evenly apply the depilatory cream to an area of ​​about 2cm×2cm. After leaving it for 2 minutes, gently wipe off the depilatory cream on the skin surface with absorbent cotton and wash it with warm water. The standard for depilation is that the mouse back is smooth and clean without any injuries or residual hair. On the second day of depilation, the composition of Examples 1 to 4 and Comparative Examples 1 to 4 is made into an ointment with vaseline (the composition content is 30%) and applied to the depilatory area. The application dose is 0.2g, once a day, for 3 consecutive weeks. Vaseline is used as a blank control. The length of new hair in the depilatory area is measured to evaluate the hair growth and anti-hair loss effect of the composition.

[0077] Test results: The average length of new hair of mice in groups 1 to 4 of Examples is higher than that of the blank control group and has a statistically significant difference (P<0.05), indicating that the anti-hair loss, oil-control and anti-dandruff compositions of Examples 1 to 4 have a hair growth and anti-hair loss effect. The average length of new hair of mice in groups 1 to 4 of Examples is higher than that of groups 1 to 4 of Comparative Examples and has a statistically significant difference (P<0.05), indicating that the hair growth and anti-hair loss effect of groups 1 to 4 of Examples is more significant. The anti-hair loss, oil-control and anti-dandruff composition of the present invention contains caffeine, glycoprotein, and tea extract ingredients, which provide sufficient nutrients for hair, promote blood circulation in the scalp, create good conditions for hair growth, help hair growth, and make hair thicker.

[0078] The above content is a further detailed description of the present invention in combination with specific preferred embodiments. Without departing from the concept of the present invention, several simple deductions or substitutions can be made, which should be regarded as falling within the protection scope of the present invention.

Claims

1. An anti-hair loss, oil control and anti-dandruff composition, comprising: Caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, purslane extract.

2. The anti-hair loss, oil control and anti-dandruff composition according to claim 1, characterized in that: The mass ratios of caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, and purslane extract are (0.5-2.5):(1-7):(0.5-3):(0.4-2.5):(0.01-0.5):(0.05-0.45):(0.8-6.5).

3. The anti-hair loss, oil control and anti-dandruff composition according to claim 2, characterized in that: The mass ratios of caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, and purslane extract are (0.8-2):(3-6):(1-2.5):(0.7-1.6):(0.1-0.3):(0.2-0.4):(2-5).

4. Use of the anti-hair loss, oil control and anti-dandruff composition according to claim 1 in the preparation of an anti-hair loss, oil control and anti-dandruff shampoo.

5. The method for preparing the anti-hair loss, oil control and anti-dandruff composition according to claim 1, comprising: Weigh caffeine, glycoprotein, tea extract, capryloyl glycine, PCA zinc, piroctone olamine salt, and purslane extract according to the mass ratio, mix well, and obtain the product.

6. An anti-hair loss, oil-control and anti-dandruff shampoo comprising: The anti-hair loss, oil control and anti-dandruff composition of claim 1, a surfactant, a moisturizer, an antioxidant, a flavor, a pigment, and purified water.

7. The anti-hair loss, oil-control and anti-dandruff shampoo according to claim 6, characterized in that: The composition comprises, by mass percentage, 3.26-22.45% of the anti-hair loss, oil control and anti-dandruff composition of claim 1, 1-20% of a surfactant, 1-15% of a moisturizer, 0.02-0.2% of an antioxidant, 0-0.1% of an essence, 0-0.1% of a pigment, and the balance of purified water.

8. The anti-hair loss, oil-control and anti-dandruff shampoo according to claim 7, characterized in that: The composition comprises, by mass percentage, 7.8-17.8% of an anti-hair loss, oil control and anti-dandruff composition, 9-18% of a surfactant, 6-14% of a moisturizer, 0.05-0.1% of an antioxidant, 0-0.03% of an essence, 0-0.01% of a pigment and the balance of purified water.

9. The anti-hair loss, oil-control and anti-dandruff shampoo according to any one of claims 6 to 8, characterized in that: The surfactant is selected from at least one of sodium laureth sulfate, sodium cocoyl glutamate, sodium cocoyl alanine, sodium lauroyl sarcosinate, sodium lauroyl aspartate, cocamidopropyl betaine, lauroyl amidopropyl betaine, cocamide monoethanolamine, sodium lauryl glucoside carboxylate, sodium lauryl ether sulfate, sodium methyl cocoyl taurate, sodium lauryl sulfoacetate, disodium lauryl sulfosuccinate, sodium lauroyl hydroxymethyl sulfonate, sodium lauroyl hydroxyethyl sulfonate, sodium lauroyl amphoacetate, coconut glucoside, lauryl glucoside, and coconut methyl glucamide; The moisturizing agent is selected from at least one of glycerin, propylene glycol, butylene glycol, pentylene glycol, hyaluronic acid, lactic acid, sodium lactate, urea, sorbitol, trehalose, sclerotium gum, vaseline, white mineral oil, squalane, panthenol, aloe extract, and ceramide; The antioxidant is selected from at least one of benzyl alcohol, phenoxyethanol, methylparaben, ethylparaben and ethylhexylglycerin.

10. The method for preparing the anti-hair loss, oil-controlling and anti-dandruff shampoo according to claim 6, comprising: S1, taking each raw material according to mass percentage; S2. Add the moisturizer to purified water, heat to 40-60°C, mix well, and keep warm for later use; S3, heat the surfactant to 65-86°C, mix well, cool to 30-50°C, and keep warm for later use; S4. Slowly add the material of step S3 to the material of step S2, mix at 30-50° C., then add the anti-hair loss, oil control and anti-dandruff composition, flavor, pigment and antioxidant in sequence, mix homogeneously, and obtain.

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