Anti-allergic and anti-chap double-effect hand cream and preparation method thereof

Abstract

The invention relates to the field of daily chemical products. The anti-allergic and anti-chap double-effect hand cream is prepared from the following components in percentage by mass: 5 to 10 percent of nanostructure lipid carrier (NLC), 3 to 5 percent of emulsifier, 1 to 3 percent of vaseline, 2 to 4 percent of beewax, 1 to 3 percent of stearic acid, 3 to 5 percent of glycerol, 0.05 to 0.1 percent of carbomer, 0.01 to 0.03 percent of pH regulator, 0.2 to 0.6 percent of preservative and the balance of purified water. The preparation method of the hand cream comprises the following steps: preparing the nanostructured lipid carrier (NLC); the preparation method comprises the following steps: weighing the emulsifier, vaseline, beeswax, stearic acid and NLC according to the prescription amount, mixing, heating and dissolving to obtain an oil phase, weighing the glycerol and carbomer according to the prescription amount, adding into pure water, stirring and dispersing uniformly to obtain a water phase, slowly adding the oil phase into the water phase, and homogenizing to obtain the product. The hand cream disclosed by the invention integrates oily and water-based lipids, the oily lipids provide a lasting lubricating effect and reduce the occurrence of skin dryness and chap, and the water-based lipids enable natural active ingredients to better permeate and improve the anti-allergic effect, so that the dual effects of resisting allergy and preventing chap are realized.

Description

Technical Field

[0001] The invention relates to the field of skin care products, in particular to a hand cream and a preparation method thereof. Background Art

[0002] The skin on the hands is easily affected by the environment, causing allergies and cracking. For people who frequently use cleaning products such as detergents and disinfectants in daily life, this will destroy the natural oils on the skin of the hands, irritate the skin, and cause allergies. In addition, the skin on the hands is prone to cracking in a cold and dry environment, which is not only unsightly, but may also cause pain and infection.

[0003] Using hand cream is the simplest and most effective way to protect the skin of your hands. Existing hand cream products can only solve the single problem of anti-allergy or anti-crack, and cannot effectively prevent allergies and cracks at the same time. Therefore, it is very necessary to develop a hand cream with both anti-allergy and anti-crack functions. Summary of the invention

[0004] The present invention aims to solve the above defects of the prior art and provide an anti-allergic and anti-cracked double-effect hand cream and a preparation method thereof. The present invention has both anti-allergic and anti-cracked functions, is convenient for users to use, and has a lower cost than two single-function hand creams.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] The invention discloses an anti-allergic and anti-chapped double-effect hand cream, which comprises, by mass percentage, 5-10% of a nanostructured lipid carrier (NLC), 3-5% of an emulsifier, 1-3% of vaseline, 2-4% of beeswax, 1-3% of stearic acid, 3-5% of glycerol, 0.03-0.1% of carbomer, 0.01-0.03% of a pH regulator, 0.2-0.6% of a preservative, and the remainder of purified water.

[0007] Further, the nanostructured lipid carrier (NLC) comprises 2-5% of gorgonian extract, 4-8% of stephania tetrandra extract, 2-5% of scutellaria root extract, 6-12% of chamomile extract, 0.5-2% of sodium hyaluronate, 0.1-3% of niacinamide, 6-12% of evening primrose oil, 4-8% of linseed oil, 2-4% of rosehip oil, 1-3% of vitamin E acetate, 1-3% of Tween-80, 4-6% of glyceryl monostearate, and the rest is purified water;

[0008] Further, the emulsifier is one or more of a combination of 1-3% sunflower lecithin, 2-5% polyglycerol fatty acid ester, and 3-5% stearic acid glyceryl;

[0009] Furthermore, the pH regulator is triethanolamine 0.01-0.03%;

[0010] Furthermore, the preservatives are 0.2-0.5% phenoxyethanol and 0.03-0.05% ethylhexylglycerin.

[0011] Preparation method:

[0012] Preparation of Nanostructured Lipid Carriers (NLC):

[0013] Add glyceryl monostearate to the first preparation tank and heat to 70-75°C until completely melted;

[0014] Add evening primrose oil, linseed oil, rosehip oil and vitamin E acetate into the first preparation tank and stir to mix evenly;

[0015] Add pure water to the second preparation tank of Gorgonian coral extract, Stephania tetrandra extract, Scutellaria root extract, Chamomile extract, sodium hyaluronate and niacinamide, and stir at room temperature for 15 minutes to make them evenly dissolved;

[0016] Place Tween-80 in the second preparation tank and stir evenly;

[0017] Heat the second preparation tank to 60°C, slowly pump the liquid in the first preparation tank into the second preparation tank, stirring at 1500 rpm for 30 minutes;

[0018] The liquid in the second preparation tank is homogenized by a high-pressure homogenizer at a homogenization pressure of 15000-20000 bar; the time is 3 minutes each time, and repeated 3 times to obtain a homogenized liquid;

[0019] The homogenate solution was rapidly cooled to 25°C to solidify the lipids to form NLC.

[0020] Preparation method of anti-allergic and anti-cracked hand cream:

[0021] Weigh the prescribed amount of emulsifier, vaseline, beeswax, stearic acid, and NLC and add them into the preparation tank. Mix and heat to dissolve at 80°C for 10 minutes to obtain liquid A.

[0022] Weigh the prescribed amount of glycerol, carbomer and pure water and add them into the preparation tank, stir and disperse them evenly, and heat to 80°C to obtain liquid B;

[0023] Slowly add liquid A into liquid B at 80°C and stirring speed of 1500rpm. Stir for 30 minutes and homogenize at 5000rpm for 10 minutes to obtain liquid C.

[0024] Cool liquid C to 40°C, add pH regulator and preservative, stir evenly for 30 minutes.

[0025] The present invention has the following characteristics:

[0026] 1. The present invention adds gorgonian extract, fennel extract, scutellaria root extract, chamomile extract, sodium hyaluronate and niacinamide as aqueous lipids, which can be quickly absorbed by the stratum corneum, inhibit inflammation and achieve anti-allergic effects;

[0027] 2. The present invention can provide a lasting lubricating effect and reduce the occurrence of dry skin and chapped skin by adding evening primrose oil, linseed oil, rosehip oil and vitamin E acetate as oily lipids;

[0028] 3. The NLC prepared by the present invention can form a protective film on the skin surface to continuously protect the skin from external stimuli;

[0029] 4. The present invention enhances the absorption and penetration of active ingredients by the skin through the controlled release characteristics of NLC;

[0030] 5. The present invention achieves the dual effects of anti-allergy and anti-crack.

[0031] 6. For users, they only need to purchase one product to achieve dual effects. It is easy to carry and use and effectively reduces the cost of use. DETAILED DESCRIPTION

[0032] The invention is realized in the following way: an anti-allergic and anti-chapped double-effect hand cream comprises, by mass percentage, 5-10% of a nanostructured lipid carrier (NLC), 3-5% of an emulsifier, 1-3% of vaseline, 2-4% of beeswax, 1-3% of stearic acid, 3-5% of glycerol, 0.03-0.1% of carbomer, 0.01-0.03% of a pH regulator, 0.2-0.6% of a preservative, and the remainder being purified water.

[0033] Further, the nanostructured lipid carrier (NLC) comprises 6-10% of gorgonian extract, 8-15% of stephania tetrandra extract, 2-5% of scutellaria root extract, 6-12% of chamomile extract, 0.5-2% of sodium hyaluronate, 0.1-3% of niacinamide, 6-12% of evening primrose oil, 4-8% of linseed oil, 2-4% of rosehip oil, 1-3% of vitamin E acetate, 1-3% of Tween-80, 4-6% of glyceryl monostearate, and the rest is purified water;

[0034] Further, the emulsifier is one or more of a combination of 1-3% sunflower lecithin, 2-5% polyglycerol fatty acid ester, and 3-5% stearic acid glyceryl;

[0035] Furthermore, the pH regulator is triethanolamine 0.01-0.03%;

[0036] Furthermore, the preservatives are 0.2-0.5% phenoxyethanol and 0.03-0.05% ethylhexylglycerin.

[0037] Preparation method:

[0038] Preparation of Nanostructured Lipid Carriers (NLC):

[0039] Add glyceryl monostearate to the first preparation tank and heat to 70-75°C until completely melted;

[0040] Add evening primrose oil, linseed oil, rosehip oil and vitamin E acetate into the first preparation tank and stir to mix evenly;

[0041] Add pure water to the second preparation tank of Gorgonian coral extract, Stephania tetrandra extract, Scutellaria root extract, Chamomile extract, sodium hyaluronate and niacinamide, and stir at room temperature for 15 minutes to make them evenly dissolved;

[0042] Place Tween-80 in the second preparation tank and stir evenly;

[0043] Heat the second preparation tank to 60°C, slowly pump the liquid in the first preparation tank into the second preparation tank, stirring at 1500 rpm for 30 minutes;

[0044] The liquid in the second preparation tank is homogenized by a high-pressure homogenizer at a homogenization pressure of 15000-20000 bar; the time is 3 minutes each time, and repeated 3 times to obtain a homogenized liquid;

[0045] The homogenate solution was rapidly cooled to 25°C to solidify the lipids to form NLC.

[0046] Preparation method of anti-allergic and anti-cracked hand cream:

[0047] Weigh the prescribed amount of emulsifier, vaseline, beeswax, stearic acid, and NLC and add them into the preparation tank. Mix and heat to dissolve at 80°C for 10 minutes to obtain liquid A.

[0048] Weigh the prescribed amount of glycerol, carbomer and pure water and add them into the preparation tank, stir and disperse them evenly, and heat to 80°C to obtain liquid B;

[0049] Slowly add liquid A into liquid B at 80°C and stirring speed of 1500rpm. Stir for 30 minutes and homogenize at 5000rpm for 10 minutes to obtain liquid C.

[0050] Cool liquid C to 40℃, add pH adjuster and preservative, stir evenly for 30 minutes.

[0051] Anti-allergic effect test:

[0052] Skin allergies can cause redness, flushing, erythema, etc. Skin hemoglobin levels are often used to assess the microcirculation and blood flow of the skin. When the skin has an inflammatory reaction, it usually leads to an increase in hemoglobin levels. By measuring hemoglobin, the inflammatory reaction of the skin can be determined.

[0053] The experiment was conducted according to the GHS-SOP-G-120 skin hemoglobin test method: Test method: 35 volunteers were tested for skin hemoglobin before use (T0), after 1 hour of use (T1), and after 8 hours of use (T2); the experimental instrument was CK, Germany, handheld test probe; after using the sample, there was a significant improvement compared with the blank control group (the blank control group was a blank sample without NLC), and the data analysis was performed using SPSS. The significance level p<0.05, then the sample had anti-allergic effect. Three test product areas and blank control areas were randomly selected on the right and left forearms of the volunteers, each area was 16 square centimeters (4cm×4cm), and low-sensitivity medical tape was applied to the middle of the test area of ​​the subject, and pressed for 15S, and the tape was torn off the skin from one end. This step was repeated 3-5 times for each area. This experiment was carried out in an environment with a temperature of 21°C and a relative humidity of 50%. Anti-chapped effect test:

[0054] The skin's anti-chapping status is judged by the transepidermal water loss value. The smaller the transepidermal water loss value, the better the skin barrier function and the better the anti-chapping effect.

[0055] The experiment was conducted according to the GHS-SOP-G-102 transepidermal water loss test method: Test method: 35 volunteers were tested for skin hemoglobin before use (T0), after use for 1 hour (T1), and after use for 8 hours (T2); the experimental instrument was CK, Germany, handheld test probe; after using the sample, there was a significant improvement compared with the blank control group (the blank control group was a blank sample without NLC), and the data analysis was performed using SPSS. The significance level p<0.05, then the sample had anti-allergic effect. Three test product areas and blank control areas were randomly selected on the right and left forearms of the volunteers, each area was 16 square centimeters (4cm×4cm), and low-sensitivity medical tape was applied to the middle of the test area of ​​the subject, and pressed for 15S, and the tape was torn off the skin from one end. This step was repeated 3-5 times for each area. This experiment was conducted at a temperature of 21°C and a relative humidity of 50%.

[0056] The present invention will be further described below in conjunction with embodiments:

[0057] Example 1

[0058] The invention discloses an anti-allergic and anti-chapped double-effect hand cream, which comprises, by mass percentage, 10% of nanostructured lipid carrier (NLC), 1% of sunflower lecithin, 3% of glyceryl stearate, 3% of vaseline, 4% of beeswax, 1% of stearic acid, 3% of glycerol, 0.03% of carbomer, 0.01% of triethanolamine, 0.5% of phenoxyethanol, 0.05% of ethylhexylglycerin, and the remainder of purified water.

[0059] According to the above efficacy test, the experimental results are as follows:

[0060] Table 1 Transepidermal water loss and skin hemoglobin test results

[0061]

[0062] *P<0.05, there is a significant difference after use compared with before use.

[0063] #P<0.05, there is a significant difference after using the sample compared with the blank control area.

[0064] Table 2 Transepidermal water loss and skin hemoglobin difference test results

[0065]

[0066] *P<0.05, compared with the blank control area, there is a significant difference after using the sample.

[0067] Example 2

[0068] An anti-allergic and anti-chapped double-effect hand cream comprises, by mass percentage: 8% nanostructured lipid carrier (NLC), 5% polyglycerol fatty acid ester, 1% vaseline, 3% beeswax, 3% stearic acid, 5% glycerol, 0.05% carbomer, 0.02% triethanolamine, 0.4% phenoxyethanol, 0.1% ethylhexylglycerol, and the rest is purified water.

[0069] According to the above efficacy test, the experimental results are as follows:

[0070] Table 3 Transepidermal water loss and skin hemoglobin test results

[0071]

[0072] *P<0.05, there is a significant difference after use compared with before use.

[0073] #P<0.05, there is a significant difference after using the sample compared with the blank control area.

[0074] Table 4 Transepidermal water loss and skin hemoglobin difference test results

[0075]

[0076] *P<0.05, compared with the blank control area, there is a significant difference after using the sample.

[0077] Example 3

[0078] The invention discloses an anti-allergic and anti-chapped double-effect hand cream, which comprises the following components by mass percentage: 5% nanostructured lipid carrier (NLC), 2% glyceryl stearate, 2% polyglycerol fatty acid ester, 3% vaseline, 2% beeswax, 3% stearic acid, 5% glycerol, 0.05% carbomer, 0.02% triethanolamine, 0.5% phenoxyethanol, 0.05% ethylhexylglycerin, and the remainder is purified water.

[0079] According to the above efficacy test, the experimental results are as follows:

[0080] Table 5 Transepidermal water loss and skin hemoglobin test results

[0081]

[0082] *P<0.05, there is a significant difference after use compared with before use.

[0083] #P<0.05, there is a significant difference after using the sample compared with the blank control area.

[0084] Table 6 Transepidermal water loss and skin hemoglobin difference test results

[0085]

[0086] *P<0.05, compared with the blank control area, there is a significant difference after using the sample.

[0087] Conclusion: Examples 1-3 all showed good anti-allergic and anti-chapped effects 8 hours after use.

[0088] The present invention provides a new idea for the development of hand cream. The present invention adds gorgonian extract, fennel extract, scutellaria root extract, chamomile extract, sodium hyaluronate, niacinamide and evening primrose oil, linseed oil, rosehip oil, and vitamin E acetate, designs a suitable ratio, and prepares a nanostructured lipid carrier (NLC) (hereinafter referred to as NLC). NLC combines oily and aqueous lipids, the oily lipids provide a lasting lubricating effect, reduce the occurrence of dry skin and chapped skin, and the aqueous lipids make the natural active ingredients penetrate better, enhance the anti-allergic effect, and achieve the dual effects of anti-allergic and anti-chapped skin.

[0089] The embodiments of the present invention disclose only the preferred embodiments of the present invention, which are only used to illustrate the technical solutions of the present invention, rather than to limit them. The purpose is to enable people familiar with the technology to understand the contents of the present invention and implement them accordingly, and they cannot be used to limit the protection scope of the present invention. Any equivalent changes or modifications made according to the spirit and essence of the present invention should be included in the protection scope of the present invention.

Claims

1. An anti-allergic and anti-crack dual-effect hand cream, characterized in that: The invention comprises, by mass percentage, 5-10% of nanostructured lipid carrier (NLC), 3-5% of emulsifier, 1-3% of vaseline, 2-4% of beeswax, 1-3% of stearic acid, 3-5% of glycerol, 0.03-0.1% of carbomer, 0.01-0.03% of pH regulator, 0.2-0.6% of preservative, and the rest of purified water.

2. The anti-allergic and anti-crack dual-effect hand cream according to claim 1, characterized in that: The nanostructured lipid carrier (NLC) comprises 6-10% of gorgonian extract, 8-15% of stephania tetrandra extract, 2-5% of scutellaria root extract, 6-12% of chamomile extract, 0.5-2% of sodium hyaluronate, 0.1-3% of niacinamide, 6-12% of evening primrose oil, 4-8% of linseed oil, 2-4% of rosehip oil, 1-3% of vitamin E acetate, 1-3% of Tween-80, 4-6% of monostearate glyceryl, and the rest is purified water, and the percentages are mass percentages, based on the nanostructured lipid carrier (NLC) as 100%.

3. The anti-allergic and anti-crack dual-effect hand cream according to claim 1, characterized in that: The emulsifier is one or more combinations of sunflower lecithin, polyglycerol fatty acid ester, and stearic acid glyceryl ester.

4. The anti-allergic and anti-crack dual-effect hand cream according to claim 1, characterized in that: The pH regulator is triethanolamine.

5. The anti-allergic and anti-crack dual-effect hand cream according to claim 1, characterized in that: The preservatives include phenoxyethanol 0.2-0.5% and ethylhexylglycerin 0.03-0.05%.

6. The method for preparing the anti-allergic and anti-crack dual-effect hand cream according to claim 1, characterized in that: It includes: S1, preparation of nanostructured lipid carriers (NLC); S2, add emulsifier, vaseline, beeswax, stearic acid, and NLC into a preparation tank, mix and heat to dissolve, the temperature is 80°C, and the stirring time is 10 minutes to obtain liquid A; S3, add glycerin, carbomer and pure water into the preparation tank, stir and disperse evenly, and heat to 80°C to obtain liquid B; S4, slowly add liquid A into liquid B, at a temperature of 80°C and a stirring speed of 1500 rpm, and homogenize after stirring for 30 minutes at a homogenizing speed of 5000 rpm and a homogenizing time of 10 minutes, to obtain liquid C; S5, cool liquid C to 40°C, add pH adjuster and preservative, stir evenly for 30 minutes, and obtain the product.

7. The method for preparing an anti-allergic and anti-crack dual-effect hand cream according to claim 6, characterized in that: The preparation of the nanostructured lipid carrier (NLC) described in S1 includes: S1-1, add glyceryl monostearate into the first preparation tank and heat to 70-75° C. until it is completely melted; S1-2, adding evening primrose oil, linseed oil, rosehip oil and vitamin E acetate into the first preparation tank, and stirring to mix evenly; S1-3 Add pure water to the second preparation tank containing gorgonian extract, fennel extract, scutellaria root extract, chamomile extract, sodium hyaluronate and niacinamide, and stir at room temperature for 15 minutes to dissolve them evenly; S1-4 Place Tween-80 in the second preparation tank and stir evenly; S1-5: Heat the second preparation tank to 60°C, slowly pump all the liquid in the first preparation tank into the second preparation tank, stirring at a speed of 1500 rpm for 30 minutes; S1-6: homogenize the liquid in the second preparation tank using a high-pressure homogenizer at a homogenization pressure of 15000-20000 bar; the time is 3 minutes each time, and the process is repeated 3 times to obtain a homogenized liquid; S1-7 Rapidly cool the liquid to 25°C to solidify the lipids to form NLC.

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