Traditional Chinese medicine composition for treating acne as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for treating acne as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 5 to 15 parts of radix scutellariae, 5 to 15 parts of yellow chrysanthemum, 10 to 20 parts of rhizoma coptidis, 5 to 15 parts of herba schizonepetae, 15 to 25 parts of cortex phellodendri, 5 to 15 parts of radix sophorae flavescentis, 5 to 15 parts of radix angelicae and 10 to 20 parts of borneol. The medicines are organically combined together through a monarch, minister, assistant and guide relationship, and have the effects of nourishing yin, purging fire, cooling blood and removing stasis. The preparation method comprises the following steps: soaking eight traditional Chinese medicinal materials in parts by weight, namely scutellaria baicalensis, yellow chrysanthemum, coptis chinensis, schizonepeta, golden cypress, angelica dahurica, sophora flavescens and borneol in water, extracting, filtering, sterilizing and filling to obtain the traditional Chinese medicinal preparation. The traditional Chinese medicine preparation can achieve a good curative effect on various types of acnes, and the effective rate reaches 100%. The invention provides a novel and effective technical means for treating acne.

Description

Technical Field

[0001] The present invention relates to a Chinese medicine composition and a preparation method and application thereof, and in particular to a Chinese medicine composition for treating acne and a preparation method and application thereof. The present invention belongs to the field of medical technology. Background Art

[0002] Acne, commonly known as pimples, blackheads, and dark acne, is called facial sores and wine thorns in ancient Chinese medicine. It is a common and frequently occurring disease in dermatology. According to statistics from scholars, 95% of males and 85% of females have suffered from acne to varying degrees during adolescence, so it is very appropriate to call it "acne". Acne (acne) is a chronic skin disease that occurs in the hair follicles and sebaceous glands, and is often found in the head, face, neck, chest, back and other parts rich in sebaceous glands.

[0003] The causes of acne are relatively complex and can be divided into the following four categories: 1. Excessive secretion of sebaceous glands: excessive male hormones (puberty, premenstrual period, polycystic ovary syndrome), excessive stress, mental tension, overtime, irregular lifestyle; excessive intake of fried, greasy, sugary foods, milk, etc. can lead to vigorous secretion of sebaceous glands. 2. A variety of microorganisms, especially Propionibacterium acnes, multiply in the hair follicles, inducing and aggravating inflammatory reactions. 3. Excessive keratinization of the sebaceous gland ducts in the hair follicles forms keratin plugs that block the pores. 4. Genetic factors, improper use of cosmetics and drugs, etc.

[0004] According to the different causes and clinical manifestations, acne can be divided into the following categories: 1. Blackhead acne: Due to excessive cortical secretion, the cortical secretion is vigorous, and the pores become smaller relatively. And the cheese-like translucent lipid plug blocked at the hair follicle mouth, after oxidation, becomes black at the outer end of the hair follicle mouth, forming a small black dot the size of a grain of rice. 2. Whitehead acne: The size of grains to mung beans, pustules form on the top of the hair follicles and papules, and the pus is viscous after breaking, and scars are left after healing. 3. Papulous acne: Acne inflammation continues to expand and deepen, making the color of acne dark red, and there is no state of pustules. Touching is accompanied by pain. 4. Pustular acne: Acne suppuration, pustules are produced in the deep layer of the skin, which is the beginning of a serious state of inflammation, and pus does not come out of the skin surface. 5. Nodular acne: The cortical block is deeply infiltrated, and the acne is dark red and protrudes from the surface, which may leave scars later. 6. Cystic acne: refers to acne with pus or sebum in the shape of pockets, which are large and red. Sebaceous cysts contain sticky pus containing blood, which easily forms scars after rupture.

[0005] Traditional Chinese medicine believes that acne is mainly caused by the congenital imbalance of kidney yin and yang, insufficient kidney yin, excessive fire and heavenly essence, and acquired dietary and lifestyle disorders, which cause heat from the lungs and stomach to rise to the head and face, and blood heat and stagnation.

[0006] Although TCM has unique advantages in treating acne, it also has its shortcomings. For example, TCM treatment of acne needs to be based on the patient's specific situation, which means that the treatment plan for each patient may be different. Although this personalized treatment can better adapt to individual differences, it may also lead to unstable treatment effects. Some patients may need to adjust the plan several times before finding the most suitable treatment method for them. In addition, the treating doctor must have high clinical experience and professional knowledge, and can accurately diagnose and formulate an individualized treatment plan, otherwise it will lead to poor clinical efficacy.

[0007] Therefore, there is an urgent need to provide a Chinese medicine composition and preparation thereof that can effectively treat and relieve various types of acne. Summary of the invention

[0008] The purpose of the present invention is to provide a Chinese medicine composition for treating acne and a preparation method and application thereof.

[0009] In order to achieve the above object, the present invention adopts the following technical means:

[0010] A Chinese medicine composition for treating acne of the present invention is composed of the following components in parts by weight:

[0011] 5-15 parts of Scutellaria baicalensis, 5-15 parts of Chrysanthemum indicum, 10-20 parts of Coptis chinensis, 5-15 parts of Schizonepeta tenuifolia, 15-25 parts of Phellodendron amurense, 5-15 parts of Sophora flavescens, 5-15 parts of Angelica dahurica and 10-20 parts of Borneolum.

[0012] Preferably, the Chinese medicine composition is composed of the following components in parts by weight:

[0013] 10 parts of Scutellaria baicalensis, 10 parts of Chrysanthemum coptidis, 15 parts of Coptidis rhizome, 10 parts of Schizonepeta tenuifolia, 20 parts of Phellodendron chinense, 10 parts of Sophora flavescens, 10 parts of Angelica dahurica, and 15 parts of Borneolum.

[0014] The Chinese medicine composition of the present invention has the effects of reducing oil secretion, antibacterial and anti-inflammatory, relieving itching and pain, reducing redness and swelling, inhibiting hair follicle keratinization, etc. on various types of acne, with significant curative effect and no side effects. Among them, Scutellaria baicalensis, bitter in taste, cold in nature, enters the lung, gallbladder, spleen, large intestine, and small intestine meridians. Clears heat and dries dampness, purges fire and detoxifies. Coptis chinensis, bitter in taste, cold in nature, enters the heart, spleen, stomach, liver, gallbladder, and large intestine meridians. Clears heat and dries dampness, purges fire and detoxifies. Phellodendron chinense, bitter in taste, cold in nature, enters the kidney and bladder meridians. Clears heat and dries dampness, purges fire and removes steam, and detoxifies and treats sores. Angelica dahurica, pungent in taste, warm in nature, enters the lung, spleen, and stomach meridians. Relieves the cold, dispels wind and relieves pain, dries dampness and stops leukorrhea, and relieves swelling and discharges pus. Chrysanthemum chrysanthemi, bitter and sweet in taste, slightly cold in nature, enters the lung and liver meridians. Disperses wind and clears heat, clears heat and detoxifies. Schizonepeta tenuifolia, pungent in taste, warm in nature, enters the lung and liver meridians. Relieves the wind, clears rash and eliminates sores. Sophora flavescens, bitter in taste and cold in nature, enters the heart, liver, stomach, large intestine, and bladder meridians. It clears away heat and dampness, kills insects and promotes diuresis, and can be used for eczema, wet sores, scabies, leprosy. Borneol, pungent, bitter, slightly cold in taste, enters the heart, spleen, and lung meridians. It clears heat and dispels toxins.

[0015] Furthermore, the present invention also proposes the use of the traditional Chinese medicine composition in the preparation of a medicine for treating acne.

[0016] Among them, preferably, the medicine is an external medicine.

[0017] Wherein, preferably, the acne includes blackheads, whiteheads, papular acne, pustular acne, nodular acne and cystic acne, and preferably, the patient is 13-40 years old.

[0018] Furthermore, the present invention also proposes a traditional Chinese medicine preparation for treating acne, which is obtained by soaking and extracting eight traditional Chinese medicines including scutellaria baicalensis, chrysanthemum scutellariae, coptis chinensis, schizonepeta tenuifolia, phellodendron amurense, angelica dahurica, sophora flavescens and borneol in water, filtering, sterilizing and filling the mixture.

[0019] Wherein, preferably, the Chinese medicine preparation is prepared by the following method:

[0020] (1) Weighing scutellaria baicalensis, chrysanthemum, coptis root, schizonepeta, phellodendron, sophora flavescens, angelica dahurica and borneol according to the above weight proportions, washing and crushing, adding 6 to 8 times the weight of the medicinal materials into water, boiling, decocting for 1 to 3 hours, and taking the filtrate;

[0021] (2) adding 4 to 6 times the weight of water to the remaining residue in step (1) and boiling for 0.5 to 1 hour to obtain the filtrate;

[0022] (3) combining the two filtrates and filtering them three times to obtain a filtrate;

[0023] (4) The filtrate is bottled and sterilized at high temperature to obtain a Chinese medicine preparation for treating acne.

[0024] Preferably, the high temperature sterilization refers to 121°C for 15-20 minutes.

[0025] Furthermore, the present invention also proposes the use of the traditional Chinese medicine preparation in the preparation of medicines for treating acne.

[0026] Wherein, preferably, the acne includes blackheads, whiteheads, papular acne, pustular acne, nodular acne and cystic acne, and preferably, the patient is 13-40 years old.

[0027] Among them, preferably, the usage of the Chinese medicine preparation is: wash the face with soap, apply the Chinese medicine preparation to the part with acne, apply it once in the morning and evening every day. Mild cases can be completely cured in 3-4 days, and severe cases can be completely cured in 10-30 days.

[0028] Compared with the prior art, the present invention has the following beneficial effects:

[0029] The present invention provides a Chinese medicine composition and preparation thereof that can effectively treat and relieve various types of acne. The Chinese medicine composition comprises scutellaria baicalensis, chrysanthemum chrysanthemum, coptis root, schizonepeta, phellodendron, sophora flavescens, angelica dahurica and borneol. The above-mentioned drugs are organically combined through the relationship of monarch, minister, assistant and envoy, and have the effects of nourishing yin, purging fire, cooling blood and dispersing stagnation. Good therapeutic effects can be achieved for various types of acne, and the effective rate reaches 100%. Therefore, the present invention provides a new and effective technical means for the treatment of acne. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 The photos of a typical case 1 are before treatment (A) and after 14 days of treatment with the Chinese medicinal preparation of the present invention (B);

[0031] Figure 2 The photos of typical case 2 are before treatment (A) and after 21 days of treatment with the Chinese medicine preparation of the present invention (B);

[0032] Figure 3 The photos of typical case 3 are before treatment (A) and after 28 days of treatment with the Chinese medicine preparation of the present invention (B). DETAILED DESCRIPTION

[0033] The technical solutions in the embodiments of the present invention will be described clearly and completely below in combination with the embodiments of the present invention. Obviously, the described embodiments are only a part of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0034] Example 1 Preparation of a Chinese medicine composition for treating acne

[0035] The Chinese medicine composition is composed of the following components by weight:

[0036] Scutellaria baicalensis 10g, Chrysanthemum scutellariae 10g, Coptis chinensis 15g, Schizonepeta tenuifolia 10g, Phellodendron chinense 20g, Sophora flavescens 10g, Angelica dahurica 10g, Borneol 15g.

[0037] Example 2 Preparation of a Chinese medicine composition for treating acne

[0038] The Chinese medicine composition is composed of the following components by weight:

[0039] Scutellaria baicalensis 15g, Chrysanthemum scutellariae 8g, Coptis chinensis 10g, Schizonepeta tenuifolia 15g, Phellodendron chinense 15g, Sophora flavescens 15g, Angelica dahurica 5g, Borneol 20g.

[0040] Example 3 Preparation of a Chinese medicine composition for treating acne

[0041] The Chinese medicine composition is composed of the following components by weight:

[0042] Scutellaria baicalensis 8g, Chrysanthemum scutellariae 15g, Coptis chinensis 20g, Schizonepeta tenuifolia 5g, Phellodendron chinense 20g, Sophora flavescens 5g, Angelica dahurica 15g, Borneol 10g.

[0043] Example 4 Preparation of a Chinese medicine preparation for treating acne ("Qudouling")

[0044] The Chinese medicine preparation is prepared by the following method:

[0045] (1) Weigh the following weights respectively: Scutellaria baicalensis, Chrysanthemum indica, Coptis chinensis, Nepeta tenuifolia, Phellodendron amurense, Sophora flavescens, Angelica dahurica and Borneol, wash and crush, add 8 times the weight of the herbs and boil, decoct for 2 hours, and collect the filtrate;

[0046] Scutellaria baicalensis 10g, Chrysanthemum scutellariae 10g, Coptis chinensis 15g, Schizonepeta tenuifolia 10g, Phellodendron chinense 20g, Sophora flavescens 10g, Angelica dahurica 10g, Borneol 15g.

[0047] (2) adding 5 times the weight of water to the remaining residue in step (1) and boiling for 1 hour to obtain the filtrate;

[0048] (3) combining the two filtrates and filtering them three times to obtain a filtrate;

[0049] (4) The filtrate is bottled and sterilized at 121° C. for 15-20 min to obtain a Chinese medicine preparation for treating acne.

[0050] The usage of the Chinese medicine preparation is as follows: wash the face with soap, apply the Chinese medicine preparation to the part with acne, apply it once in the morning and evening every day. The mild case can be completely cured in 3-4 days, and the severe case can be completely cured in 10-30 days.

[0051] Example 5 Application of Chinese medicine preparation ("Qudouling") in the treatment of acne

[0052] 1. A total of 50 patients were included in the experiment of the present invention, including 22 males and 28 females; aged 13-40 years old, with the shortest course of disease being 1 month and the longest being 3 years. The degree of skin lesions reached grade III in 12 cases, grade II in 25 cases, and grade I in 13 cases.

[0053] 2. Clinical grading standards for acne severity:

[0054] Grade I (mild): The main skin lesions are acne, which occur on the face.

[0055] Grade II (moderate): The main skin lesions are acne, with a certain amount of papules and superficial pustules, mainly occurring on the face, and a small amount on the neck, chest and back.

[0056] Grade III (severe) The main skin lesions are deep inflammatory papules and pustules, which occur on the face, neck, chest and back.

[0057] 3. Inclusion criteria: patients with typical clinical manifestations, meeting the above diagnostic criteria for acne vulgaris, not taking any medication within one month, and not suffering from other diseases. Patients who are allergic to this product and those who have been using corticosteroids for a long time are excluded.

[0058] 4. Medication and observation method: Wash the face with soap, apply the Chinese medicine preparation (prepared in Example 4) to the acne-affected area once a day in the morning and evening. Observe the efficacy every week for a total of one month.

[0059] 5. The following criteria are used to determine the efficacy:

[0060] Cured: symptoms basically disappear, efficacy index ≥ 95%;

[0061] Markedly effective: symptoms are significantly improved, with an efficacy index of 60-95%;

[0062] Effective: Symptoms improved, with an efficacy index of 20-60%;

[0063] Ineffective: efficacy index <20%

[0064] The clinical results are shown in Table 1 below:

[0065] Table 1 Clinical results

[0066] Number of cases get well Significant effect efficient invalid Efficiency Level I 12 12 0 0 0 100％ Level II 25 20 3 2 0 100％ Level III 13 10 1 2 0 100％

[0067] Typical cases:

[0068] Typical case 1: Ms. Li, a 23-year-old female student, had repeatedly sought medical advice for multiple papules on her face. She had used a variety of medications, including retinoic acid cream and retinoic acid cream, but to no avail. Before taking the medication, both cheeks had acne of varying sizes ( Figure 1 A), redness and swelling, accompanied by itching. The Chinese medicine preparation of the present invention ("Qu Diao Ling") was applied once a day in the morning and evening. After 14 days of observation, the skin at the acne site was basically restored to a smooth color, close to the surrounding skin, and there was no itching ( Figure 1 B).

[0069] Typical case 2: Zhao Moumou, female, 25 years old, company employee, suffered from this disease for more than half a year and was diagnosed with acne. No acne removal products were used. The skin on the forehead and cheeks felt uneven, with closed comedones, pustules, redness and inflammation on the face, which was moderate acne ( Figure 2 A). Apply the Chinese medicine preparation ("Qu Diao Ling") of the present invention once in the morning and evening every day. Observe once every 7 days. After 14 days, the face feels relaxed and the itching and pain are reduced by half. After 21 days, the disease is cured ( Figure 2 B).

[0070] Typical case 3: Xia, female, 35 years old, company employee, complained of repeated acne and follicular red papules on the forehead and face for 3 years. In the past 3 years, she had repeated black and white acne and follicular red papules on the forehead and face, which were sometimes mild and sometimes severe. Before taking the medicine, she had multiple pustules on her forehead and cheeks, with scattered red papules and scars left after the rupture of cysts, and occasional mild itching ( Figure 3 A). Apply the Chinese medicine preparation ("Qu Diao Ling") of the present invention once every morning and evening. Observe once every 7 days. After 14 days, the redness and swelling are alleviated, the face feels relaxed, and the itching and pain are halved. After 28 days, the patient is basically cured ( Figure 3 B).

Claims

1. A Chinese medicine composition for treating acne, characterized in that: It is composed of the following components in parts by weight: 5-15 parts of Scutellaria baicalensis, 5-15 parts of Chrysanthemum indicum, 10-20 parts of Coptis chinensis, 5-15 parts of Schizonepeta tenuifolia, 15-25 parts of Phellodendron amurense, 5-15 parts of Sophora flavescens, 5-15 parts of Angelica dahurica and 10-20 parts of Borneolum.

2. The Chinese medicine composition according to claim 1, characterized in that: It is composed of the following components in parts by weight: 10 parts of Scutellaria baicalensis, 10 parts of Chrysanthemum coptidis, 15 parts of Coptidis rhizome, 10 parts of Schizonepeta tenuifolia, 20 parts of Phellodendron chinense, 10 parts of Sophora flavescens, 10 parts of Angelica dahurica, and 15 parts of Borneolum.

3. Use of the Chinese medicine composition according to claim 1 or 2 in the preparation of a drug for treating acne.

4. The use according to claim 3, characterized in that The medicine is an external medicine.

5. The use according to claim 3, characterized in that The acne includes blackhead comedones, whitehead comedones, papular acne, pustular acne, nodular acne and cystic acne. Preferably, the patient is 13-40 years old.

6. A Chinese medicine preparation for treating acne, characterized in that: The Chinese medicine preparation is obtained by soaking and extracting eight Chinese medicinal materials of weight portions as claimed in claim 1 or 2, namely, scutellaria baicalensis, chrysanthemum, coptis root, schizonepeta, phellodendron, angelica dahurica, sophora flavescens and borneol, filtering, and then sterilizing and filling.

7. The Chinese medicine preparation according to claim 6, characterized in that: The Chinese medicine preparation is prepared by the following method: (1) Weigh scutellaria baicalensis, chrysanthemum, coptis root, schizonepeta, phellodendron, sophora flavescens, angelica dahurica and borneol according to the weight proportions of claim 1 or 2, wash and crush, add 6 to 8 times the weight of the medicinal materials into water, boil, decoct for 1 to 3 hours, and take the filtrate; (2) adding 4 to 6 times the weight of water to the remaining residue in step (1) and boiling for 0.5 to 1 hour to obtain the filtrate; (3) combining the two filtrates and filtering them three times to obtain a filtrate; (4) The filtrate is bottled and sterilized at high temperature to obtain a Chinese medicine preparation for treating acne.

8. The Chinese medicine preparation according to claim 6, characterized in that: The high temperature sterilization refers to 121°C, sterilization for 15-20 minutes.

9. Use of the Chinese medicine preparation according to claim 6 or 7 in the preparation of a drug for treating acne.

10. The use according to claim 9, characterized in that The acne includes blackhead comedones, whitehead comedones, papular acne, pustular acne, nodular acne and cystic acne. Preferably, the patient is 13-40 years old.

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