Traditional Chinese medicine composition for reducing lipid and resolving dampness as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention provides a traditional Chinese medicine composition for reducing lipid and resolving dampness. The invention also provides a traditional Chinese medicine decoction. The invention further provides a traditional Chinese medicine extract and a preparation method thereof. The invention further provides a traditional Chinese medicine preparation. The invention further provides a traditional Chinese medicine beverage and a preparation method thereof. The invention further provides application of the traditional Chinese medicine composition, the traditional Chinese medicine decoction, the traditional Chinese medicine extract, the traditional Chinese medicine preparation or the traditional Chinese medicine drink in preparation of medicines for lowering lipid and resolving dampness. According to the traditional Chinese medicine composition for reducing lipid and resolving dampness and the preparation method and application thereof, the lipid-reducing and dampness-resolving effect is remarkable, the taste is superior to that of traditional bitter medicines, and the traditional Chinese medicine composition is simple, convenient and easy to eat so as to meet the health-preserving requirements of modern people.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to a lipid-reducing and dampness-eliminating traditional Chinese medicine composition and a preparation method and application thereof. Background Art

[0002] With the improvement of people's quality of life and changes in living habits, the incidence of hyperlipidemia is on the rise. Dyslipidemia, which belongs to the category of metabolic diseases, refers to the disorder of lipid metabolism in the blood. Its onset is hidden. Generally, patients have no obvious symptoms and signs. Most of them are found during physical examinations. It is manifested as increased serum total cholesterol (TC), serum low-density lipoprotein (LDL-C), serum triglyceride (TG) levels, and decreased serum high-density lipoprotein (HDL-C) levels. Dyslipidemia is closely related to the morbidity and mortality of coronary heart disease, atherosclerosis, stroke, fatty liver, etc. The "Guidelines for Blood Lipid Management in China (2023)" points out that my country is facing a continuous upward trend in the burden of atherosclerosis, which is increasing year by year and tends to be younger. Therefore, blood lipid management is urgent. By intervening in early dyslipidemia, helping patients control blood lipid indicators within a reasonable range, avoiding related complications and cardiovascular and cerebrovascular accidents caused by hyperlipidemia, it is of great significance to improve the quality of life of patients and prolong their survival time, which is in line with the scope of TCM prevention of disease. It is now generally recognized that a decrease in high-density lipoprotein cholesterol is also one of the risk factors for the occurrence and development of cardiovascular diseases. Therefore, current literature mostly uses the concept of dyslipidemia to replace hyperlipidemia.

[0003] Dyslipidemia is mainly discovered through routine clinical examinations and routine health examinations. The "Guidelines for the Prevention and Treatment of Dyslipidemia in Chinese Adults" recommends that adults over 20 years old should measure fasting blood lipids once every 5 years, men over 40 years old and postmenopausal women should have blood lipid tests every year, and for people with ischemic cardiovascular disease and high-risk groups, blood lipids should be measured once every 3-6 months. There are not many clinical manifestations of dyslipidemia itself. The main ones are that lipid deposition in the dermis and eyes can cause xanthomas, fundus changes with hyperlipidemia, and corneal rings. These can be found during physical examinations, but the incidence is not high. Obvious hypertriglyceridemia can cause acute pancreatitis, and lipid deposition in the vascular endothelium leads to atherosclerosis, causing coronary heart disease, cerebrovascular disease, and peripheral vascular disease. Blood lipid levels are greatly affected by people's lifestyles and eating habits, and are also related to gender, age, etc. Therefore, the concept of "normal value" is not advocated at present. Instead, an appropriate range is provided based on the impact of blood lipid levels on the occurrence and development of cardiovascular disease. The "Guidelines for the Prevention and Treatment of Dyslipidemia in Chinese Adults" put forward the following appropriate blood lipid levels for the Chinese population: the appropriate range of TC is <5.18mmol / L, 5.1-6.19mmol / L is borderline elevated, and TC ≥6.22mmol / L is elevated; the appropriate range of TG is <1.7mmol / L, 1.70-2.25mmol / L is borderline elevated, and TG ≥2.26mmol / L is elevated; the appropriate range of LDL-C is <3.37mmol / L, 3.37-4.12mmol / L is borderline elevated, and LDL-C ≥4.14mmol / L is elevated; the appropriate range of HDL-C is ≥1.04mmol / L, and HDL-C <1.04mmol / L is decreased.

[0004] In ancient literature, traditional medicine did not establish an independent disease name for hyperlipidemia. Modern doctors mostly use the definition of "blood turbidity" in the "Terms of Clinical Diagnosis and Treatment of Traditional Chinese Medicine" promulgated in 1997, which corresponds to the hyperlipidemia diagnosed by Western medicine. Some Chinese medicine scholars believe that this disease should be classified as "fat cream", "phlegm dampness" and "blood stasis" in traditional Chinese medicine, and doctors of all dynasties have made in-depth explanations on this. For example, the "Yellow Emperor's Internal Classic" points out that people with too much fat cream are called "fat people" and "paste people". "Medical Biography" says: "Body fluid is thick and sticky, it is phlegm and drink, it accumulates for a long time and seeps into the veins, and the blood becomes turbid." It is proposed that fat cream is generated by the essence of water and grain in the middle jiao, and the dysfunction of the spleen's transportation and transformation function leads to abnormal distribution of body fluid, thus producing dampness and phlegm. Over time, these turbid evils will gather into cream and fat. Zhang Zhicong, a doctor in the Qing Dynasty, said about creams and fats: "The qi in the middle jiao steams and turns into fluids, and its fine substances... make the fat fat, and if there is too much fat in the body, the fat fat will be full." He pointed out that the qi in the middle jiao steams and turns into fluids, and its fine substances form fat fat. If there is too much fat fat in the body, it will lead to full fat fat. Traditional Chinese medicine believes that the formation of hyperlipidemia is closely related to the liver, spleen, and kidney. The main pathogenesis is the dysfunction of the internal organs such as spleen dysfunction, liver dysfunction, and kidney qi deficiency, which leads to metabolic disorders of the body, dysfunction of fluid transportation, and then the formation of water dampness and phlegm. If water dampness and phlegm are retained for a long time, it can affect the blood, leading to poor meridians and blood stasis. Phlegm and stasis are both the basic pathological products of hyperlipidemia, and they can also serve as new pathogenic factors, hindering the normal operation of qi and causing each other's diseases. According to statistics, spleen deficiency and dampness obstruction are common symptoms of hyperlipidemia, and phlegm and blood stasis are common pathological products of dyslipidemia. Therefore, in clinical practice, the method of strengthening the spleen and eliminating dampness is often used to treat early dyslipidemia. Traditional Chinese medicine has attracted much attention in recent years due to its outstanding advantages of multiple targets, safety, effectiveness and diversified measures.

[0005] Western medicine treatment of dyslipidemia may cause adverse reactions such as abnormal liver function, muscle pain, and gastrointestinal discomfort. However, the safety of traditional Chinese medicine is relatively high. At present, the combination of Chinese and Western medicine has been widely used in the treatment of dyslipidemia. Compared with Western medicine, traditional Chinese medicine treatment has the characteristics of less side effects and high safety, and can fundamentally adjust the patient's constitution to achieve the effect of treating both the symptoms and the root causes. Looking to the future, the research on the relationship between the "phlegm, dampness, and stasis" theory and dyslipidemia will be further deepened. More traditional Chinese medicine prescriptions and treatment methods can be explored to improve clinical effects. Summary of the invention

[0006] In view of the shortcomings of the prior art described above, the purpose of the present invention is to provide a lipid-lowering and dampness-removing Chinese medicine composition and its preparation method and application, which are used to solve the current problems of an increasing number of people with "marginal elevated blood lipids", obvious phlegm-dampness symptoms in traditional Chinese medicine, patients resisting Western medicine treatment or not reaching the stage of Western medicine treatment, not paying attention to their own abnormal blood lipids, and thus missing the best time to intervene in the early stage of the disease.

[0007] In order to achieve the above-mentioned object and other related objects, the present invention provides a lipid-lowering and dampness-removing Chinese medicine composition in a first aspect, comprising the following raw material components by weight:

[0008] Astragalus 25-35 parts;

[0009] 10-20 parts of Codonopsis pilosula;

[0010] 25-35 servings of coix seed;

[0011] 5-15 parts of Pueraria root;

[0012] 10-20 copies of Daidaihua;

[0013] 5-15 portions of citron;

[0014] 5-15 parts lotus leaves;

[0015] 5-15 servings of raw hawthorn;

[0016] 5-15 servings of Buddha’s Hand;

[0017] 1-10 servings of papaya;

[0018] 1-5 parts of licorice.

[0019] The second aspect of the present invention provides a Chinese medicine decoction, which is obtained by taking the Chinese medicine composition of the first aspect of the present invention as a raw material, soaking it in water, decocting it over high heat and then decocting it over low heat.

[0020] The third aspect of the present invention provides a Chinese medicine extract, which is obtained by extracting the Chinese medicine composition described in the first aspect of the present invention as a raw material.

[0021] The fourth aspect of the present invention provides a method for preparing the above-mentioned Chinese medicine extract, comprising: mixing the various raw material components of the Chinese medicine composition described in the first aspect of the present invention according to a ratio, and extracting the obtained mixture using at least one method selected from low-temperature grinding or extraction and concentration.

[0022] The fifth aspect of the present invention provides a Chinese medicine preparation, comprising a therapeutically effective amount of the Chinese medicine composition provided by the first aspect of the present invention, a therapeutically effective amount of the Chinese medicine decoction provided by the second aspect of the present invention, or a therapeutically effective amount of the Chinese medicine extract provided by the third aspect of the present invention, and one or more conventional pharmaceutically acceptable excipients.

[0023] The sixth aspect of the present invention provides a Chinese medicinal beverage, comprising the Chinese medicinal extract provided in the third aspect of the present invention and auxiliary materials, wherein the auxiliary materials include the following components by weight:

[0024] Compound colloid 1-2 parts;

[0025] 1-2 portions of sugar substitute;

[0026] 1-2 portions of fruit powder;

[0027] 1-2 parts of sodium citrate.

[0028] The seventh aspect of the present invention provides a method for preparing a Chinese herbal beverage, comprising: mixing the Chinese herbal extract provided by the third aspect of the present invention with the components of the auxiliary materials provided by the sixth aspect of the present invention, filtering the mixture for the first time, stirring and mixing the mixture after heating, and then continuing to heat the mixture to completely dissolve the mixture, and filtering the mixture for the second time to provide the desired Chinese herbal beverage.

[0029] The eighth aspect of the present invention provides the Chinese medicine composition provided in the first aspect of the present invention, the second aspect of the present invention provides the Chinese medicine decoction, the third aspect of the present invention provides the Chinese medicine extract, the fifth aspect of the present invention provides the Chinese medicine preparation, or the sixth aspect of the present invention provides the Chinese medicine drink in the preparation of a drug for lowering lipids and removing dampness.

[0030] As described above, the lipid-lowering and dampness-removing Chinese medicine composition provided by the present invention and its preparation method and application are aimed at people with "marginal elevated blood lipids" who have obvious symptoms of phlegm and dampness in traditional Chinese medicine, who resist Western medicine treatment or have not reached the stage of Western medicine treatment, who do not pay attention to their own abnormal blood lipids and miss the best period for intervention in the early stage of the disease. The beverage preparation process is combined with the Chinese medicine compound extraction process, and the artificially selected Chinese medicine materials with medicinal and edible properties are extracted into a high-concentration nutrient essence stock solution, and the natural flavor is scientifically formulated to develop a functional health drink with a suitable taste - a lipid-lowering drink with medicinal and edible properties. Based on the ancient recipe, it is highly purified through a modern refined extraction process, and its efficacy is nearly 10 times that of traditional Chinese medicine, and the lipid-lowering and dampness-removing effect is significant. The taste is better than traditional bitter medicines, and it is simple and easy to eat to meet the health needs of modern people. DETAILED DESCRIPTION

[0031] Before further describing the specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terms used in the examples of the present invention are intended to describe specific embodiments, rather than to limit the scope of protection of the present invention. The test methods in the following examples without specifying specific conditions are generally carried out under conventional conditions or under conditions recommended by the manufacturers.

[0032] When the embodiments give numerical ranges, it should be understood that, unless otherwise specified in the present invention, both endpoints of each numerical range and any numerical value between the two endpoints can be selected. Unless otherwise defined, all technical and scientific terms used in the present invention have the same meaning as those generally understood by those skilled in the art. In addition to the specific methods, equipment, and materials used in the embodiments, according to the grasp of the prior art by those skilled in the art and the record of the present invention, any methods, equipment, and materials of the prior art similar or equivalent to the methods, equipment, and materials described in the embodiments of the present invention can also be used to realize the present invention.

[0033] Unless otherwise stated, the experimental methods, detection methods, and preparation methods disclosed in the present invention all adopt conventional techniques in the technical field.

[0034] The first aspect of the present invention provides a lipid-lowering and dampness-removing Chinese medicine composition, which comprises the following raw material components by weight:

[0035] 25-35 parts of Astragalus; specifically 25-28 parts, 28-32 parts, 32-35 parts;

[0036] Codonopsis pilosula 10-20 parts; specifically, 10-12 parts, 12-18 parts, 18-20 parts;

[0037] 25-35 parts of coix seed; specifically 25-28 parts, 28-32 parts, 32-35 parts;

[0038] 5-15 parts of Pueraria root; specifically, 5-8 parts, 8-12 parts, 12-15 parts;

[0039] 10-20 portions of Daidaihua; specifically, 10-12 portions, 12-18 portions, 18-20 portions;

[0040] Citron 5-15 parts; specifically 5-8 parts, 8-12 parts, 12-15 parts;

[0041] 5-15 parts of lotus leaves; specifically, 5-8 parts, 8-12 parts, 12-15 parts;

[0042] 5-15 parts of raw hawthorn; specifically 5-8 parts, 8-12 parts, 12-15 parts;

[0043] 5-15 parts of bergamot; specifically 5-8 parts, 8-12 parts, 12-15 parts;

[0044] 1-10 portions of papaya; specifically, 1-4 portions, 4-8 portions, 8-10 portions;

[0045] 1-5 parts of licorice; specifically, 1-2 parts, 2-4 parts, 4-5 parts.

[0046] In the present invention, the astragalus is the dried root of the leguminous plant Astragalus membranaceus or Astragalus membranaceus, which has the effects of invigorating qi and raising yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, promoting body fluid and nourishing blood, relieving stagnation and relieving arthritis, expelling toxins and discharging pus, and healing sores and promoting tissue regeneration.

[0047] In the present invention, the Codonopsis pilosula is the dried root of Codonopsis pilosula, Codonopsis pilosula or Codonopsis pilosula of Campanulaceae, which has the effects of strengthening the spleen and lungs, nourishing blood and promoting the production of body fluids.

[0048] In the present invention, the coix seed is the dried mature seed of the Gramineae plant Coix, which has the effects of promoting diuresis and eliminating dampness, strengthening the spleen and stopping diarrhea, removing arthralgia, discharging pus, and detoxifying and dispersing nodules.

[0049] In the present invention, the kudzu root is the dried root of the leguminous plant kudzu, which has the effects of relieving muscles and reducing fever, promoting body fluid, clearing rashes, and raising yang and stopping diarrhea.

[0050] In the present invention, the herb is the flower bud of the herb of the Rutaceae plant, and has the effects of promoting qi and relieving fullness, promoting digestion, resolving phlegm, soothing the liver and regulating qi, harmonizing the stomach and stopping vomiting.

[0051] In the present invention, the citron is the dried mature fruit of the Rutaceae plant Citron or Citron citron, which has the effects of soothing the liver and regulating qi, relieving fullness and resolving phlegm.

[0052] In the present invention, the lotus leaf is the dried leaf of a perennial herbaceous emergent plant of the genus Nelumbo of the family Nelumbo, and has the effects of clearing away heat and relieving summer heat, stopping bleeding, and promoting diuresis and detoxification.

[0053] In the present invention, the raw hawthorn is the dried mature fruit of the plant Shanlihong or Crataegus pinnatifida of the Rosaceae family, and has the effects of promoting digestion and strengthening the stomach, promoting qi and dispersing blood stasis, and clearing turbidity and reducing fat.

[0054] In the present invention, the bergamot is the dried fruit of the Rutaceae plant bergamot, which has the effects of soothing the liver and regulating qi, harmonizing the stomach and relieving pain, and drying dampness and resolving phlegm.

[0055] In the present invention, the papaya is a dried nearly mature fruit of a plant of the Rosaceae family, and has the effects of relaxing muscles and tendons, activating collaterals, and harmonizing the stomach and removing dampness.

[0056] In the present invention, the licorice is the dried root and rhizome of the leguminous plants licorice, licorice inflated fruit or licorice glabra, which has the effects of invigorating qi and tonifying the middle, removing phlegm and relieving cough, detoxifying, relieving acute pain and alleviating medicinal properties.

[0057] The above-mentioned raw materials (or medicinal materials) used in the present invention can be purchased from ordinary medical stores or Chinese medicinal material sales companies. Their specifications meet national medical standards or meet relevant regulations such as the Chinese Pharmacopoeia, and are all included in the catalog of medicinal and edible products stipulated by the former Ministry of Health.

[0058] The lipid-reducing and dampness-removing Chinese medicine composition of the present invention fully follows the principle of syndrome differentiation and treatment of traditional Chinese medicine, wherein Astragalus and Codonopsis are the main medicines, Astragalus replenishes qi and nourishes the middle, and is used for qi deficiency, fatigue, poor appetite and loose stools; Codonopsis replenishes the middle and replenishes qi, harmonizes the stomach and produces body fluid, and is used for spleen deficiency, poor appetite and loose stools, weakness in the limbs, palpitations, and shortness of breath. The two medicines are combined as the main medicines, and they jointly replenish the weakness of the middle jiao spleen and stomach, and target the symptoms of indigestion, dampness and other symptoms caused by dyslipidemia, and replenish without stagnation, and replenish without greasiness. Coix seed, kudzu root, daidaihua, citron, lotus leaf and raw hawthorn are all ministerial drugs. Coix seed "is sweet and mild in nature, can clear the turbidity in the middle, can strengthen the spleen yin, and greatly benefit the stomach and intestines". Coix seed is sweet and mild in nature, can penetrate and nourish, can promote diuresis without hurting the body, can strengthen the spleen without nourishing greasiness, can relieve the symptoms of dampness in people with dyslipidemia. Modern pharmacological research shows that coix seed can relieve excess cholesterol in the blood, prevent arteriosclerosis, etc. Pueraria root is pungent, sweet and cool, can promote the clear yang, encourage the clear yang of the spleen and stomach to rise and stop the spleen deficiency. The loose stools and diarrhea caused by the citron can regulate blood lipids, blood pressure, and blood sugar levels; Daidaihua can regulate qi and relieve fullness. Modern pharmacological research shows that it has a gastrointestinal motility effect and can assist in weight loss; Citron is good at soothing the liver and spleen qi, treating liver depression and qi stagnation, spleen and stomach qi stagnation, promoting gastrointestinal peristalsis, and has the effect of lowering blood lipids; Lotus leaf clears away heat and dampness, promotes the clear yang, has the effects of lowering fat and weight loss, lowering blood pressure, anti-oxidation, and scavenging free radicals; Hawthorn can help digestion and strengthen the spleen, promote qi and disperse blood stasis, and is used for meat stagnation and stomach distension. All the ministerial drugs have the effects of strengthening the spleen, removing dampness, digesting food, and lowering fat, which can relieve many discomforts caused by early dyslipidemia and spleen deficiency and dampness obstruction. Buddha's hand and papaya are adjuvants. Buddha's hand regulates qi and harmonizes the middle, soothes the liver and relieves depression, improves appetite, enhances gastrointestinal function, and effectively relieves symptoms such as stomach fullness and loss of appetite; papaya harmonizes the stomach and eliminates dampness, strengthens the spleen and digests food, and significantly reduces serum alanine aminotransferase levels. Licorice is a guiding drug, which nourishes the spleen and replenishes qi, clears away heat and detoxifies, and harmonizes various drugs. When various drugs are used together and matched with each other, they can exert their synergistic therapeutic effects.

[0059] In a preferred embodiment of the present invention, the lipid-lowering and dampness-removing Chinese medicine composition comprises the following raw material components by weight:

[0060] 28-32 parts of Astragalus, preferably 30 parts;

[0061] 12-18 parts of Codonopsis pilosula, preferably 15 parts;

[0062] 28-32 parts of coix seeds; preferably 30 parts;

[0063] 8-12 parts of Pueraria root, preferably 10 parts;

[0064] 12-18 portions of daidaihua, preferably 15 portions;

[0065] 8-12 parts of citron, preferably 10 parts;

[0066] 8-12 parts of lotus leaves; preferably 10 parts;

[0067] 8-12 parts of raw hawthorn, preferably 10 parts;

[0068] 8-12 parts of bergamot, preferably 10 parts;

[0069] 4-8 portions of papaya, preferably 6 portions;

[0070] 2-4 parts of liquorice; preferably 3 parts.

[0071] The second aspect of the present invention provides a Chinese medicine decoction, which is obtained by taking the Chinese medicine composition of the first aspect of the present invention as a raw material, soaking it in water, decocting it over high heat and then decocting it over low heat.

[0072] In a preferred embodiment of the present invention, the amount of cold water added is enough to cover the medicine.

[0073] In a preferred embodiment of the present invention, the soaking time is 30-60 minutes, such as 30-45 minutes, 45-60 minutes.

[0074] In a preferred embodiment of the present invention, the temperature of the high-fire decocting is 100-105°C, such as 100-102°C, 102-105°C.

[0075] In a preferred embodiment of the present invention, the time for decocting over high heat is 10-20 minutes, such as 10-16 minutes or 16-20 minutes.

[0076] In a preferred embodiment of the present invention, the temperature of decocting over low heat is 50-60°C, such as 50-55°C, 55-60°C.

[0077] In a preferred embodiment of the present invention, the time for decocting over low heat is 25-35 minutes, such as 25-32 minutes or 32-35 minutes.

[0078] In a preferred embodiment of the present invention, the decoction volume is 390-410 mL, such as 390-405 mL, 405-410 mL.

[0079] The third aspect of the present invention provides a Chinese medicine extract, which is obtained by extracting the Chinese medicine composition described in the first aspect of the present invention as a raw material.

[0080] The fourth aspect of the present invention provides a method for preparing the above-mentioned Chinese medicine extract, comprising: mixing the various raw material components of the Chinese medicine composition described in the first aspect of the present invention according to a ratio, and extracting the obtained mixture using at least one method selected from low-temperature grinding or extraction and concentration.

[0081] In the present invention, each raw material component in the formula of the Chinese medicine composition is the most critical. After knowing the formula of the Chinese medicine composition, technicians in this technical field can use various extraction methods of effective ingredients of Chinese medicine to extract its effective ingredients according to the characteristics of different raw material components in the Chinese medicine composition, such as low-temperature grinding method, leaching concentration method, etc.

[0082] In a preferred embodiment of the present invention, the cryogenic grinding method comprises: adding water to the mixture and soaking it at low temperature, and then performing cryogenic grinding to provide the Chinese herbal medicine extract.

[0083] In a further preferred embodiment of the present invention, the ratio of the mass (g) of the mixture added to the volume (mL) of the water added is 1:3.5-4.5, specifically 1:3.5-4.2, 1:4.2-4.5. That is, the water is 3.5-4.5 times the amount of the mixture, specifically 3.5-4.2 times, 4.2-4.5 times.

[0084] In a further preferred embodiment of the present invention, the temperature of the low-temperature soaking is 60-70°C, such as 60-65°C, 65-70°C.

[0085] In a further preferred embodiment of the present invention, the low-temperature soaking time is 60-120 min, specifically 60-90 min, 90-120 min.

[0086] In a further preferred embodiment of the present invention, the cryogenic grinding is performed in a colloid mill.

[0087] In a further preferred embodiment of the present invention, the temperature of the cryogenic grinding is -190 to -60°C, such as -190 to -125°C, -125 to -60°C.

[0088] In a further preferred embodiment of the present invention, the rotation speed of the cryogenic grinding is 1000-1500 rpm, such as 1000-1200 rpm, 1200-1500 rpm.

[0089] In a further preferred embodiment of the present invention, the cryogenic grinding is performed into particles, and the particle size of the particles is not less than 300 meshes. The particles are crushed into ultrafine powders, and the particle size is fine and uniform.

[0090] In a preferred embodiment of the present invention, the extraction and concentration method comprises: soaking the mixture in water, boiling, filtering, and concentrating to provide the traditional Chinese medicine extract.

[0091] In a further preferred embodiment of the present invention, the ratio of the mass (g) of the mixture added to the volume (mL) of the water added is 1:8-12, specifically 1:8-11, 1:11-12. That is, the water is 8-12 times the amount of the mixture, specifically 8-11 times, 11-12 times.

[0092] In a further preferred embodiment of the present invention, the soaking is performed at room temperature, which is 20-30°C.

[0093] In a further preferred embodiment of the present invention, the soaking time is 60-120 min, specifically 60-90 min, 90-120 min.

[0094] In a further preferred embodiment of the present invention, the cooking is performed until boiling.

[0095] In a further preferred embodiment of the present invention, the boiling time is 40-60 min, specifically 40-50 min, 50-60 min.

[0096] In a further preferred embodiment of the present invention, the filtration is a conventional filtration method, such as filter mesh filtration, filter cloth filtration, etc.

[0097] In a further preferred embodiment of the present invention, the concentration is vacuum concentration, and the vacuum degree of the vacuum concentration is 60-80kPa, such as 60-66kPa, 66-76kPa, 76-80kPa; the temperature of the vacuum concentration is 50-65°C, such as 50-56°C, 56-61°C, 61-65°C; the time of the vacuum concentration is 4-10h, such as 4-6h, 6-9h, 9-10h.

[0098] After the effective ingredients in the traditional Chinese medicine composition are extracted by the above preparation method, conventional pharmaceutical excipients and additives can be used to prepare the above pharmaceutical composition.

[0099] The fifth aspect of the present invention provides a Chinese medicine preparation, comprising a therapeutically effective amount of the Chinese medicine composition provided by the first aspect of the present invention, a therapeutically effective amount of the Chinese medicine decoction provided by the second aspect of the present invention, or a therapeutically effective amount of the Chinese medicine extract provided by the third aspect of the present invention, and one or more conventional pharmaceutically acceptable excipients.

[0100] Pharmaceutically acceptable adjuvants include, but are not limited to, pharmaceutically acceptable carriers, diluents, fillers, binders, disintegrants, lubricants, suspending agents, adhesives, sweeteners, flavoring agents, preservatives and other excipients. Inert inorganic or organic carriers known to those skilled in the art include, but are not limited to, lactose, corn starch or its derivatives, talc, vegetable oils, waxes, fats, polyol compounds such as polyethylene glycol, water, sucrose, ethanol, glycerol, and the like, various preservatives, lubricants, dispersants, flavoring agents. Moisturizers, antioxidants, sweeteners, colorants, stabilizers, salts, buffers and the like may also be added thereto, and these substances are used to help the stability of the formulation or to help improve the activity or its biological effectiveness as required.

[0101] In a preferred embodiment of the present invention, the dosage form of the Chinese medicine preparation includes but is not limited to tablets, capsules, pills, syrups, granules, powders, pastes, pellets, suspensions or emulsions.

[0102] The above-mentioned various dosage forms of Chinese medicine preparations can be prepared by conventional methods. The Chinese medicine preparations of the present invention can also be used together with other therapeutic agents.

[0103] The therapeutically effective amount in the present invention is calculated based on the total weight of the raw medicinal materials. The specific dosage should also take into account factors such as the route of administration and the patient's health status, which are all within the skills of skilled physicians.

[0104] The sixth aspect of the present invention provides a Chinese medicinal beverage, comprising the Chinese medicinal extract provided in the third aspect of the present invention and auxiliary materials, wherein the auxiliary materials include the following components by weight:

[0105] 1-2 parts of compound colloid; specifically 1-1.5 parts, 1.5-2 parts;

[0106] 1-2 parts of sugar substitute; specifically, 1-1.5 parts, 1.5-2 parts;

[0107] 1-2 parts of fruit powder; specifically, 1-1.5 parts, 1.5-2 parts;

[0108] Sodium citrate 1-2 parts; specifically 1-1.5 parts, 1.5-2 parts.

[0109] The auxiliary materials are calculated in the same weight ratio as the Chinese herbal extract provided in the third aspect of the present invention.

[0110] Among the above auxiliary materials, the compound colloid is sodium alginate.

[0111] Among the above auxiliary materials, the sugar substitute is stevia, which is stevioside obtained from stevia leaves and refined.

[0112] Among the auxiliary materials, the fruit powder is banana powder, which is obtained by grinding fresh bananas into powder after processing.

[0113] The seventh aspect of the present invention provides a method for preparing a Chinese herbal beverage, comprising: mixing the Chinese herbal extract provided by the third aspect of the present invention with the components of the auxiliary materials provided by the sixth aspect of the present invention, filtering the mixture for the first time, stirring and mixing the mixture after heating, and then continuing to heat the mixture to completely dissolve the mixture, and filtering the mixture for the second time to provide the desired Chinese herbal beverage.

[0114] In the above preparation method, the Chinese medicinal beverage is a sol.

[0115] In the above preparation method, the first filtration is screen filtration.

[0116] In a preferred embodiment of the present invention, the mesh size of the sieve is 40-60 mesh, specifically 40-55 mesh, 55-60 mesh.

[0117] In the above preparation method, the heating is performed by adding the mixture into hot water for heating.

[0118] In the above preparation method, the heating temperature is 35-55°C, such as 35-42°C, 42-51°C, 51-55°C.

[0119] In the above preparation method, the heating time is 10-20 minutes, specifically 10-16 minutes, 16-20 minutes. The stirring and mixing is used to make the components evenly mixed and fully swollen.

[0120] In the above preparation method, the continued heating temperature is 75-95°C, specifically 75-82°C, 82-91°C, 91-95°C.

[0121] In the above preparation method, the continued heating time is 40-55 minutes, specifically 40-46 minutes, 46-51 minutes, 51-55 minutes.

[0122] In the above preparation method, the second filtration is filter cloth filtration.

[0123] In a preferred embodiment of the present invention, the filter cloth has a filter mesh number of 90-110 meshes, specifically 90-102 meshes, 102-110 meshes.

[0124] In the above preparation method, the Chinese medicinal beverage is also subjected to cooling and heat preservation, pH adjustment, flavoring, filling, sterilization, cold water cooling, air drying, and sealing to obtain the finished product.

[0125] In a preferred embodiment of the present invention, in the cooling and heat preservation, the temperature is cooled to 65-75°C and kept warm, specifically 65-71°C, 71-75°C.

[0126] In a preferred embodiment of the present invention, the pH is adjusted to neutral, and the specific pH value is 6.9-7.1, preferably 7.

[0127] In a preferred embodiment of the present invention, the fragrance adjustment, filling, sterilization, cold water cooling, air shower drying and sealing are all conventional processing processes.

[0128] In a further preferred embodiment of the present invention, the filling is performed by stirring evenly after flavoring and then filling while hot.

[0129] In a further preferred embodiment of the present invention, the sterilization temperature is 80-90°C, such as 80-86°C, 86-90°C.

[0130] In a further preferred embodiment of the present invention, the sterilization time is 15-25 minutes, such as 15-21 minutes, 21-25 minutes.

[0131] The eighth aspect of the present invention provides the Chinese medicine composition provided in the first aspect of the present invention, the second aspect of the present invention provides the Chinese medicine decoction, the third aspect of the present invention provides the Chinese medicine extract, the fifth aspect of the present invention provides the Chinese medicine preparation, or the sixth aspect of the present invention provides the Chinese medicine drink in the preparation of a drug for lowering lipids and removing dampness.

[0132] The present invention is further described below in conjunction with specific examples. It should be understood that these examples are only used to illustrate the present invention and are not used to limit the scope of protection of the present invention.

[0133] The following describes the embodiments of the present invention through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present invention.

[0134] The production processes, experimental methods or detection methods involved in the embodiments and comparative examples of the present invention are all conventional methods in the prior art unless otherwise specified, and their names and / or abbreviations are all conventional names in the field and are very clear and unambiguous in the relevant application fields. Those skilled in the art can understand the conventional process steps based on the names and apply the corresponding equipment to implement them according to conventional conditions or the conditions recommended by the manufacturer.

[0135] The various instruments, equipment, raw materials or reagents used in the embodiments of the present invention are not particularly limited in terms of their sources, and are all conventional products that can be purchased through regular commercial channels, or can be prepared according to conventional methods well known to those skilled in the art.

[0136] Example 1

[0137] The raw material components of the lipid-lowering and dampness-removing Chinese medicine composition were taken by weight, namely: 30 weight parts of astragalus, 15 weight parts of Codonopsis pilosula, 30 weight parts of Coix seeds, 10 weight parts of Pueraria root, 15 weight parts of Daisy flower, 10 weight parts of Citron, 10 weight parts of lotus leaf, 10 weight parts of raw hawthorn, 10 weight parts of citron, 6 weight parts of papaya, and 3 weight parts of licorice, to obtain Chinese medicine composition sample 1#.

[0138] Example 2

[0139] The raw material components of the lipid-lowering and dampness-removing Chinese medicine composition were taken by weight, namely: 28 weight parts of astragalus, 18 weight parts of Codonopsis pilosula, 28 weight parts of Coix seeds, 12 weight parts of Pueraria root, 12 weight parts of Daisy flower, 12 weight parts of Citron, 8 weight parts of lotus leaf, 12 weight parts of raw hawthorn, 8 weight parts of citron, 8 weight parts of papaya, and 4 weight parts of liquorice, to obtain Chinese medicine composition sample 2#.

[0140] Example 3

[0141] The raw material components of the lipid-lowering and dampness-removing Chinese medicine composition were taken by weight, namely: 32 weight parts of Astragalus, 12 weight parts of Codonopsis, 32 weight parts of Coix seeds, 8 weight parts of Pueraria, 18 weight parts of Daisy, 8 weight parts of Citron, 12 weight parts of lotus leaves, 8 weight parts of raw hawthorn, 12 weight parts of citron, 4 weight parts of papaya, and 2 weight parts of liquorice, to obtain Chinese medicine composition sample 3#.

[0142] Example 4

[0143] The Chinese medicine composition sample 1# of Example 1 was mixed according to the proportion, and then pure water was added to cover the medicine, and the mixture was soaked for 40 minutes. The mixture was decocted at 100°C for 15 minutes, then decocted at 60°C for 30 minutes, and finally decocted 400 mL to obtain Chinese medicine decoction sample 1#. Chinese medicine decoction sample 1# can be taken warm, twice a day, for one month.

[0144] Example 5

[0145] The Chinese medicine composition sample 2# of Example 2 was mixed according to the proportion, and then pure water was added to cover the medicine, and the mixture was soaked for 38 minutes. The mixture was decocted at 100°C for 13 minutes, then decocted at 60°C for 28 minutes, and finally decocted 400 mL to obtain Chinese medicine decoction sample 2#. Chinese medicine decoction sample 2# can be taken warm, twice a day, for one month.

[0146] Example 6

[0147] The Chinese medicine composition sample 3# of Example 3 was mixed according to the proportion, and then pure water was added to cover the medicine, and the mixture was soaked for 42 minutes. The mixture was decocted at 102°C for 17 minutes, and then decocted at 56°C for 32 minutes. Finally, 395 mL was decocted to obtain Chinese medicine decoction sample 3#. Chinese medicine decoction sample 3# can be taken warm, twice a day, for one month.

[0148] Example 7

[0149] The Chinese medicine composition sample 1# of Example 1 was mixed according to the proportion, and then pure water was added to cover the medicine, and the mixture was soaked for 46 minutes. The mixture was decocted at 103°C for 18 minutes, and then decocted at 52°C for 34 minutes. Finally, 405 mL was decocted to obtain Chinese medicine decoction sample 4#. Chinese medicine decoction sample 4# can be taken warm, twice a day, for one month.

[0150] Example 8

[0151] The Chinese medicine composition sample 1# of Example 1 was mixed according to the ratio, and the effective components were extracted by leaching and concentration method to obtain Chinese medicine extract sample 1*. The mixture was soaked in 11 times the amount of water at room temperature for 90 minutes, boiled to a boil for 50 minutes, filtered, and concentrated for 9 hours under the conditions of a vacuum degree of 77 kPa and a temperature of 62°C to obtain.

[0152] Example 9

[0153] The Chinese medicine composition sample 2# of Example 2 was mixed according to the ratio, and the effective components were extracted by leaching and concentration method to obtain Chinese medicine extract sample 2*. The mixture was soaked in 10 times the amount of water at room temperature for 60 minutes, boiled to a boil for 40 minutes, filtered, and concentrated for 6 hours under the conditions of a vacuum degree of 70 kPa and a temperature of 57°C to obtain.

[0154] Example 10

[0155] The Chinese medicine composition sample 3# of Example 3 was mixed according to the proportions, and the effective components were extracted by cryogenic grinding to obtain Chinese medicine extract sample 3*. The mixture was added with 4 times the amount of water and soaked at 60°C for 60 minutes, and then added to a colloid mill and ground at -120°C at a speed of 1500 rpm into particles with a particle size of 300 mesh to obtain.

[0156] Embodiment 11

[0157] The Chinese medicine composition sample 1# of Example 1 was mixed according to the proportions, and the effective components were extracted by cryogenic grinding to obtain Chinese medicine extract sample 4*. The mixture was added with 4.5 times the amount of water and soaked at 65°C for 90 minutes, and then added to a colloid mill and ground at -110°C at a speed of 1200 rpm into particles with a particle size of 400 mesh to obtain.

[0158] Example 12

[0159] According to weight, take 1 part of compound colloid, 1 part of sugar substitute, 1 part of fruit powder, and 1 part of sodium citrate to obtain auxiliary material sample 1*. Mix auxiliary material sample 1* with the Chinese medicine extract sample 1* of Example 8, pass through a 57-mesh sieve, add it to 52°C hot water and heat it for 17 minutes, stir it to mix it evenly and fully swell it. Continue to heat it in 92°C hot water for 52 minutes to completely dissolve it, then pass it through a 105-mesh filter cloth, cool it to 72°C in the mixing tank to keep it warm, adjust the pH to 7, dissolve it in a proper amount of water to make a solution for flavoring, stir it evenly after flavoring, and then fill it while it is hot, sterilize it at 88°C for 23 minutes, cool it with cold water, air dry it, and seal it to obtain Chinese medicine beverage 1.

[0160] Embodiment 13

[0161] Take 2 parts of compound colloid, 2 parts of sugar substitute, 2 parts of fruit powder, and 2 parts of sodium citrate to obtain auxiliary material sample 2*. Mix auxiliary material sample 2* with the Chinese medicine extract sample 2* of Example 9, pass through a 50-mesh sieve, add it to 45°C hot water and heat it for 15 minutes, stir it to mix it evenly and fully swell it. Continue to heat it in 85°C hot water for 48 minutes to completely dissolve it, then pass it through a 100-mesh filter cloth, cool it to 70°C in the mixing tank to keep it warm, adjust the pH to 7, dissolve it into a solution with an appropriate amount of water for flavoring, stir it evenly after flavoring, and then fill it while it is hot, sterilize it at 85°C for 20 minutes, cool it with cold water, air dry it, and seal it to obtain Chinese medicine beverage 2.

[0162] Embodiment 14

[0163] Take 1 part of compound colloid, 1 part of sugar substitute, 1 part of fruit powder, and 1 part of sodium citrate to obtain auxiliary material sample 3*. Mix auxiliary material sample 3* with the Chinese medicine extract sample 4* of Example 11, pass through a 55-mesh sieve, add it to 43°C hot water and heat it for 19 minutes, stir it to mix it evenly and fully swell it. Continue to heat it in 83°C hot water for 49 minutes to completely dissolve it, then pass it through a 95-mesh filter cloth, cool it to 68°C in the mixing tank to keep it warm, adjust the pH to 7, dissolve it into a solution with an appropriate amount of water for flavoring, stir it evenly after flavoring, and then fill it while it is hot, sterilize it at 89°C for 18 minutes, cool it with cold water, air dry it, and seal it to obtain Chinese medicine beverage 3.

[0164] Embodiment 15

[0165] 1. Case sources: patients visiting our hospital's physical examination center, outpatient clinic of the Department of Preventive Medicine, and the entire hospital, who met the diagnostic criteria for marginal elevation of hyperlipidemia. The 90 patients who passed the inclusion and exclusion criteria were randomly divided into a treatment group and a control group with 45 cases in each group.

[0166] 2. Diagnostic criteria

[0167] 2.1 Western medicine standards: According to the "Guidelines for the Prevention and Treatment of Dyslipidemia in Chinese Adults", the appropriate blood lipid levels for the Chinese population are: TC of 5.1-6.19mmol / L is borderline elevated, and TC ≥6.22mmol / L is elevated; TG of 1.70-2.25mmol / L is borderline elevated, and TG ≥2.26mmol / L is elevated; LDL-C of 3.37-4.12mmol / L is borderline elevated, and LDL-C ≥4.14mmol / L is elevated; any one of the above conditions is sufficient.

[0168] 2.2 TCM Standards: Based on the Guidelines for Clinical Research of New Chinese Medicines (Trial) and TCM Internal Medicine, the specific standards for phlegm-dampness syndrome are as follows:

[0169] Main symptoms: obesity, heaviness of the head, numbness and heaviness of limbs, chest tightness, nausea and vomiting of phlegm;

[0170] Secondary symptoms: palpitations, insomnia, loss of appetite, tasteless mouth, fatigue, loose stools;

[0171] Tongue and pulse: pale, fat or large tongue, greasy white or white and smooth tongue coating, slippery pulse.

[0172] 3. Inclusion criteria

[0173] ①Age between 18 and 75, regardless of gender;

[0174] ② Meet the diagnostic criteria for borderline hyperlipidemia;

[0175] ③This study was approved by the Ethics Committee of Shanghai Seventh People's Hospital, and the subjects signed informed consent and voluntarily participated in the clinical trial;

[0176] ④The subjects have not taken related drugs within six months.

[0177] 4. Exclusion criteria:

[0178] ①Triglyceride ≥5.7mmol / L;

[0179] ② Those with severe mental disorders and unable to take care of themselves;

[0180] ③Breastfeeding or pregnant women;

[0181] ④Secondary to other diseases.

[0182] 5. Treatment methods

[0183] 5.1 Basic Education:

[0184] ① Treatment group: Chinese medicine decoction sample 1# prepared in Example 4 was used. Take warm, twice a day.

[0185] ②Control group: Zhibitai (Chengdu Diao Pharmaceutical) was used in addition to basic treatment, 1 tablet at a time, twice a day.

[0186] One course of treatment was 4 weeks, and the symptom changes before and after 3 courses of treatment were observed.

[0187] 6. Observation indicators

[0188] ① General indicators: heart rate (beats / minute), pulse (beats / minute), respiration (beats / minute), blood pressure (mmHg);

[0189] ② TCM symptom score: formulated with reference to the "Guidelines for Clinical Research of New Chinese Medicines (Trial)", the main symptoms include: obesity, heavy head, numbness and heaviness of limbs, chest tightness, nausea and vomiting; secondary symptoms include: palpitations, insomnia, fatigue, loose stools, bland taste and poor appetite. From mild to severe symptoms, 2, 4, and 6 are used to represent them respectively, and those without the symptom are recorded as 0. The specific TCM symptom score of spleen deficiency and dampness obstruction syndrome is shown in Table 1.

[0190] Table 1

[0191]

[0192]

[0193] ③ Laboratory indicators: serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C);

[0194] ④Other indicators: weight, body mass index, waist circumference;

[0195] ⑤Safety indicators: three routine tests, liver function, kidney function, and electrocardiogram.

[0196] 7. Efficacy evaluation

[0197] 7.1 Evaluation criteria for efficacy of blood lipid levels

[0198] ①Clinical control: All objective laboratory lipid level tests return to normal;

[0199] ② Significant effect: Any of the following items in the blood lipid level test meets the following conditions: TC decreases ≥ 20%, TG decreases ≥ 40%, and HDL-C increases ≥ 0.26mmol / L;

[0200] ③ Effective: Any of the blood lipid level tests meets the following conditions: TC decreases ≥10% but <20%; TG decreases ≥20% but <40%; HDL-C increases ≥0.104mmol / L but <0.26mmol / L;

[0201] ④Invalid: blood lipid test does not meet the above standards.

[0202] 7.2 TCM Syndrome Therapeutic Evaluation Criteria

[0203] ①Clinical control: clinical symptoms and signs disappear or almost disappear, and syndrome score decreases by ≥95%;

[0204] ② Significantly effective: clinical symptoms and signs are significantly improved, and the syndrome score is reduced by ≥70%;

[0205] ③Effective: clinical symptoms and signs are improved, and the syndrome score is reduced by ≥30%;

[0206] ④ Ineffective: There is no significant improvement in clinical symptoms and signs, or they may even worsen, and the syndrome score decreases by less than 30%.

[0207] 8. Statistical methods

[0208] SPSS 26.0 software was used for statistical analysis, and the quantitative data were One-way analysis of variance was used to compare measurement data among multiple groups, LSD method was used for pairwise comparison between groups, paired t test was used for comparison before and after treatment within each group, and X2 test was used for count data. P < 0.05 was considered statistically significant.

[0209] 9. Efficacy

[0210] 9.1 Comparison of total TCM syndrome scores between the two groups: After treatment, the total syndrome score of the treatment group decreased significantly compared with that of the control group, and the difference was statistically significant (P < 0.05), as shown in Table 2.

[0211] Table 2 Comparison of total TCM syndrome scores between the two groups

[0212] Group Total score of TCM syndrome before treatment Total score of TCM syndrome after treatment Treatment group (n=45) 19.90±3.53 6.87±1.89 Control group (n=45) 19.47±4.02 9.13±2.04

[0213] 9.2 Comparison of the efficacy of clinical symptoms between the two groups: The total effective rate of the treatment group was 93.3%, and that of the control group was 77.8%, with a statistically significant difference (P < 0.05), as shown in Table 3.

[0214] Table 3 Comparison of clinical efficacy between the two groups [n (%)]

[0215] Group cure Significant effect efficient invalid Total Effectiveness Treatment group (n=45) 8 16 18 3 42(93.3) Control group (n=45) 3 12 20 10 35(77.8)

[0216] 9.3 Comparison of laboratory indicators between the two groups: The changes in laboratory indicators in the treatment group were more obvious than those in the control group, and the differences were statistically significant (P<0.05), as shown in Table 4.

[0217] Table 4 Comparison of laboratory indicators between the two groups before and after treatment mmol / L

[0218]

[0219] As shown in Tables 2-4, the Chinese medicine composition and Chinese medicine mixture of the present invention can effectively improve the symptoms and laboratory indicators of marginally elevated blood lipids. As shown in Table 4, after treatment, cholesterol TC and triglyceride TG decreased, and high-density lipoprotein HDL-C increased.

[0220] Example 16

[0221] 1. Case 1

[0222] Mr. Wang, male, 35 years old, Department of Preventive Medicine, Shanghai Seventh People’s Hospital, clinic number: G4423**A6

[0223] The patient was admitted to the hospital because of "elevated blood lipids accompanied by fatigue and loose stools during physical examination". The patient gained 11 pounds in weight in the past six months, with an enlarged abdomen, poor spirits during the day, sticky and uncomfortable mouth, fatigue, loose stools, diarrhea after eating spicy and heavy food, and thick and greasy tongue coating. Exercise is accompanied by chest tightness, palpitations, heavy limbs, and no obvious weight loss effect. Denied other chronic disease history and family history, no other medications were taken recently. Four Chinese medicine examinations: pale red tongue, enlarged tongue, white and greasy coating, and slippery pulse. Four indicators of blood lipids in physical examination (mmol / L): TC5.93, TG3.31, HDL-C0.94, LDL-C4.21. Diagnosed with marginal elevated blood lipids, Chinese medicine diagnosis was dampness obstruction disease-spleen deficiency and dampness obstruction syndrome. The treatment is intended to strengthen the spleen, eliminate dampness and reduce fat. The patient was given a water decoction of the Chinese medicine combination formula, such as Chinese medicine decoction sample 1#, for oral administration for 3 months. The patient lost weight, the blood lipid level returned to normal, and the symptoms of heavy body, fatigue and loose stools disappeared.

[0224] 2. Case 2

[0225] Chen, female, 45 years old, Department of Preventive Medicine, Shanghai Seventh People's Hospital, clinic number: D2015**80

[0226] The patient was admitted for treatment due to "elevated blood lipids and obesity in physical examination". The patient was obese, especially in the abdomen and buttocks. He felt that his limbs were heavy and difficult to stick to weight loss. He said that his diet had been controlled, but the weight loss effect was not obvious, and he liked to eat sweets. The menstrual cycle was delayed and the menstrual flow was small. . Four Chinese medicine examinations: pale and fat tongue, with teeth marks on the edges, greasy white fur, and slippery pulse. Four indicators of blood lipids in physical examination (mmol / L): TC 6.13, TG2.36, HDL-C 1.21, LDL-C 4.56. The diagnosis was marginal elevation of blood lipids, and the Chinese medicine diagnosis was dampness obstruction disease-spleen deficiency and dampness obstruction syndrome. The treatment was to strengthen the spleen, eliminate dampness and reduce lipids. The water decoction of this Chinese medicine combination formula, such as Chinese medicine decoction sample 4#, was given orally for 3 months. The patient's blood lipid level returned to normal, and the weight loss was obvious after exercise and diet.

[0227] The above is only a preferred embodiment of the present invention, and is not any formal or substantial limitation of the present invention. It should be pointed out that ordinary technicians in this technical field can make several improvements and supplements without departing from the method of the present invention, and these improvements and supplements should also be regarded as the protection scope of the present invention. Any technician familiar with this profession, without departing from the spirit and scope of the present invention, can make some changes, modifications and evolutions of the technical content disclosed above, which are equivalent embodiments of the present invention; at the same time, any changes, modifications and evolutions of any equivalent changes made to the above embodiments based on the essential technology of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. A Chinese medicine composition, comprising the following raw material components by weight: Astragalus 25-35 parts; 10-20 parts of Codonopsis pilosula; 25-35 servings of coix seed; 5-15 parts of Pueraria root; 10-20 copies of Daidaihua; 5-15 portions of citron; 5-15 lotus leaves; 5-15 servings of raw hawthorn; 5-15 servings of Buddha’s Hand; 1-10 servings of papaya; 1-5 parts of licorice.

2. A Chinese medicine decoction, which is obtained by soaking the Chinese medicine composition according to claim 1 as a raw material in water, decocting it over high heat and then decocting it over low heat.

3. A Chinese medicine extract obtained by extracting the Chinese medicine composition according to claim 1 as raw material.

4. A method for preparing a Chinese medicine extract, comprising: The raw material components of the Chinese medicine composition according to claim 1 are mixed according to the ratio, and the obtained mixture is extracted by at least one method selected from the group consisting of low-temperature grinding method and leaching concentration method.

5. The method for preparing the Chinese herbal medicine extract according to claim 4, characterized in that: The method comprises any one or more of the following conditions: A1) the cryogenic grinding method comprises: soaking the mixture in water at low temperature, and then performing cryogenic grinding to provide the Chinese herbal medicine extract; Preferably, the ratio of the mass of the mixture added to the volume of water added is 1:3.5-4.5, g / mL; And / or, the low-temperature soaking temperature is 60-70°C; And / or, the low-temperature soaking time is 60-120 min; And / or, the temperature of the cryogenic grinding is -190 to -60°C; And / or, the rotation speed of the cryogenic grinding is 1000-1500 rpm; and / or, the cryogenic grinding forms particles, the particle size of the particles being not less than 300 mesh; A2) The extraction and concentration method comprises: soaking the mixture in water, boiling, filtering and concentrating to provide the Chinese herbal medicine extract; Preferably, the ratio of the mass of the mixture added to the volume of water added is 1:8-12, g / mL; And / or, the soaking is carried out at room temperature; And / or, the soaking time is 60-120 min; And / or, boiling; And / or, the boiling time is 40-60 min; And / or, the concentration is vacuum concentration, the vacuum degree of the vacuum concentration is 60-80 kPa; the temperature of the vacuum concentration is 50-65° C.; the time of the vacuum concentration is 4-10 h.

6. A Chinese medicine preparation comprising a therapeutically effective amount of the Chinese medicine composition according to claim 1, a therapeutically effective amount of the Chinese medicine decoction according to claim 2, or a therapeutically effective amount of the Chinese medicine extract according to claim 3, and one or more conventional pharmaceutically acceptable excipients.

7. A Chinese medicinal beverage, comprising the Chinese medicinal extract according to claim 3 and auxiliary materials, wherein the auxiliary materials comprise the following components by weight: Compound colloid 1-2 parts; 1-2 portions of sugar substitute; 1-2 portions of fruit powder; 1-2 parts of sodium citrate.

8. A method for preparing a Chinese medicinal beverage, comprising: The Chinese herbal extract according to claim 3 is mixed with the components of the auxiliary materials according to claim 7, filtered for the first time, stirred and mixed after heating, and then continued to heat to make it completely dissolved and then filtered for the second time to provide the desired Chinese herbal beverage.

9. The method for preparing the Chinese medicinal beverage according to claim 8, characterized in that: Including any one or more of the following conditions: B1) the Chinese medicinal beverage is a sol; B2) the first filtration is sieve filtration; preferably, the mesh size of the sieve is 40-60 mesh; B3) The heating is adding into hot water for heating; B4) the heating temperature is 35-55°C; B5) the heating time is 10-20 minutes; B6) the continued heating temperature is 75-95°C; B7) the continued heating time is 40-55 minutes; B8) The second filtration is performed by filtering with a filter cloth; preferably, the filter cloth has a mesh size of 90-110 meshes; B9) The Chinese herbal medicine beverage is further subjected to cooling and heat preservation, pH adjustment, flavoring, filling, sterilization, cold water cooling, air drying, and sealing to obtain a finished product; Preferably, during the cooling and heat preservation, the temperature is cooled to 65-75° C. and kept warm; and / or, adjusting the pH to neutral; And / or, the sterilization temperature is 80-90°C; And / or, the sterilization time is 15-25 minutes.

10. Use of the Chinese medicine composition according to claim 1, the Chinese medicine decoction according to claim 2, the Chinese medicine extract according to claim 3, the Chinese medicine preparation according to claim 6, or the Chinese medicine drink according to claim 7 in the preparation of a drug for reducing lipids and eliminating dampness.

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