Traditional Chinese medicine composition for relieving gouty arthritis and preparation method

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for relieving gouty arthritis and a preparation method. According to the traditional Chinese medicine composition, traditional Chinese medicines such as rhizoma corydalis, rhizoma chuanxiong, notopterygium root, radix curcumae and radix aucklandiae are utilized to form the traditional Chinese medicine composition for treating qi as the commander of blood, qi circulation is used for promoting blood circulation, qi circulation is beneficial to promoting blood circulation, qi circulation is promoted, blood circulation is increased, discharge of uric acid in the body is promoted, the body constitution is enhanced, the immunity is improved, meanwhile, kidney tonifying and qi benefiting are achieved, and qi and blood of the spleen and kidney are coordinated; the treatment effect on gout is improved. The traditional Chinese medicine can effectively remove pathogenic qi of damp turbidity, can treat both symptoms and root causes, and has a good effect of relieving and treating gout. Clinical practice proves that the traditional Chinese medicine composition for treating gout has a good effect of treating gouty arthritis caused by hyperuricemia, and has a tranquilizing effect.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for relieving gouty arthritis and a preparation method thereof. Background Art

[0002] Gout is a heterogeneous chronic metabolic disease caused by purine metabolism disorders or uric acid excretion disorders due to various reasons, which causes tissue damage. It is also called hyperuricemia. Gout is divided into acute gout and chronic gout based on clinical symptoms. Acute gout attacks suddenly and can be induced by trauma, surgery, excessive drinking, etc., and has gouty arthritis as clinical manifestations. Joints are red, swollen, hot, with obvious tenderness, and limited joint movement, which seriously affect normal life.

[0003] At present, the pathogenesis of gout has not been fully revealed and it is still impossible to completely cure it. Long-term comprehensive treatment mainly combines uric acid lowering and anti-inflammatory analgesic drugs with diet control. At present, colchicine is the first choice for the treatment of acute attacks of gout in clinical practice. However, colchicine is highly toxic and has many adverse reactions, which can cause symptoms such as nausea, vomiting, and diarrhea. Combined with other non-steroidal anti-inflammatory drugs, such as ibuprofen and diclofenac diethylamine, as therapeutic drugs to relieve the inflammation of acute attacks of gout, uric acid lowering drugs are used for uric acid lowering treatment after the acute symptoms are relieved. Non-steroidal anti-inflammatory drugs can also cause more complications and adverse reactions, causing greater pain to patients.

[0004] Traditional Chinese medicine has obvious advantages in treating gout. It is effective and safe, has few side effects, can stably control the progression of the disease, prevent complications, etc., and is more easily accepted by patients. Summary of the invention

[0005] The purpose of the present invention is to provide a Chinese medicine composition for relieving gouty arthritis and a preparation method thereof, so as to make up for the deficiencies in the prior art and achieve better anti-gout therapeutic effects.

[0006] A traditional Chinese medicine composition for relieving gouty arthritis, comprising the following components by mass: 16-29 parts of Corydalis yanhusuo, 11-17 parts of chuanxiong, 7-13 parts of notopterygium wilfordii, 10-18 parts of curcuma, 5-12 parts of costusroot, 9-14 parts of ginger stone, 8-16 parts of Yuanshen, 11-19 parts of yam, 10-22 parts of cornus, and 12-26 parts of liquorice.

[0007] Preferably, the Chinese medicine composition comprises the following components by mass: 26 parts of Corydalis yanhusuo, 15 parts of chuanxiong, 11 parts of notopterygium wilfordii, 14 parts of curcuma, 8 parts of costusroot, 11 parts of ginger stone, 12 parts of Yuanshen, 14 parts of yam, 17 parts of cornus, and 21 parts of liquorice.

[0008] Preferably, the dosage form of the Chinese medicine composition is a decoction.

[0009] The present invention further provides a method for preparing a Chinese medicine composition for relieving gouty arthritis, characterized in that the preparation method comprises the following steps: (1) crushing the raw materials of the Chinese medicine composition, performing steam explosion treatment on the crushed materials, and collecting the steam explosion materials; (2) mixing the steam explosion material with water in a mass ratio of 1:10 to 18, soaking, heating, filtering, collecting the first filtrate, collecting the filter residue, steaming the filter residue for a second time, filtering, and collecting the second filtrate; (3) The first filtrate and the second filtrate are combined, concentrated, filtered, and the filtrate is collected to obtain a Chinese medicine composition for relieving gouty arthritis.

[0010] Preferably, the conditions for steam explosion in step (1) are: the solvent is water, the mass ratio of water to the raw materials of the Chinese medicine composition is 10:1, the pressure is 1.3 MPa, and the pressure is maintained for 90 to 100 seconds.

[0011] Corydalis yanhusuo: warm in nature, pungent and bitter in taste. Enters the liver meridian and spleen meridian. Functions and indications: activate blood circulation, dissipate blood stasis, regulate qi, and relieve pain.

[0012] Chuanxiong: warm in nature, pungent in taste. Enters the liver meridian, gallbladder meridian, and pericardium meridian. Functions and effects: activates blood circulation and qi, dispels wind and relieves pain.

[0013] Qianghuo: warm in nature, pungent and bitter in taste. Enters the bladder meridian and kidney meridian. Functions and effects: dispel cold, dispel wind and dampness, and relieve pain.

[0014] Curcuma: cold in nature, pungent and bitter in taste. Enters the liver meridian, heart meridian, and lung meridian. Functions and effects: promote blood circulation and relieve pain, promote qi and cure scabies, clear the heart and relieve depression, promote bile and relieve jaundice.

[0015] Muxiang: warm in nature, pungent and bitter in taste. It enters the spleen meridian, stomach meridian, large intestine meridian, triple burner meridian, and gallbladder meridian. Functions and effects: promotes qi and relieves pain, strengthens the spleen and helps digestion. It is a qi-regulating drug.

[0016] Jiangshi: salty in taste, cold in nature. Enters the heart and stomach meridians. Effects and functions: clears away heat, detoxifies and reduces swelling.

[0017] Yuanshen: sweet, bitter and salty. Effects and functions: cooling blood, nourishing yin, purging fire and detoxifying.

[0018] Chinese Yam: sweet, warm, neutral, this meridian. Efficacy and function: mainly treats injuries, replenishes the weak, removes cold and heat evil spirits, replenishes the middle, strengthens the qi and strength, grows muscles, and strengthens the yin. Long-term use can make the ears and eyes brighter, lighten the body, and prolong life.

[0019] Cornus officinalis: slightly warm in nature, sour and astringent in taste. Enters the liver and kidney meridians. Functions and effects: nourishes the liver and kidneys, astringes and consolidates.

[0020] Licorice: neutral in nature, sweet in taste. It enters the heart meridian, stomach meridian, spleen meridian, and lung meridian. Functions and effects: tonifies the spleen and replenishes qi, relieves cough and expectorants, relieves pain, and harmonizes the properties of medicines. Beneficial Effects

[0021] Gout belongs to the category of "arthralgia" in traditional Chinese medicine, and blood uric acid is closely related to the onset of gout, which is considered by traditional Chinese medicine to belong to the category of "dampness and turbidity". Due to excessive endogenous dampness and turbidity in the human body, spleen and kidney dysfunction occurs, the spleen fails to function properly, and the kidney cannot separate the clear from the turbid, then the dampness and turbidity flow into the joints and muscles, causing poor circulation of qi and blood, and blockage of meridians, resulting in pain, which is also called gouty arthritis. If the dampness and turbidity cannot be completely eliminated, it will further lead to kidney damage, namely gouty nephropathy, or even chronic renal failure.

[0022] The Chinese medicine composition for relieving gouty arthritis of the present invention has established a treatment method that takes qi as the leader of blood, qi movement leads to blood movement, qi movement helps blood movement, ventilation and blood movement increase blood circulation, promotes the discharge of uric acid in the body, strengthens physical fitness, improves immunity, and simultaneously tonifies the kidney and replenishes qi, coordinates the qi and blood of the spleen and kidney, and improves the therapeutic effect on gout. It effectively removes damp and turbid evil qi, achieves simultaneous treatment of the symptoms and the root cause, and has a good effect of relieving and treating gout. The Chinese medicine composition for treating gout of the present invention has been confirmed by clinical practice to have a good effect of treating gouty arthritis caused by high uric acid, and has a stable effect. DETAILED DESCRIPTION

[0023] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. Example 1

[0024] 16g Corydalis yanhusuo, 11g Chuanxiong, 7g Notopterygium wilfordii, 10g Curcuma aromatica, 5g Aucklandia lappa, 9g Ginger stone, 8g Yuanshen, 11g Dioscorea opposita, 10g Cornus officinalis, and 12g Licorice.

[0025] The preparation method of the traditional Chinese medicine composition for relieving gouty arthritis comprises the following steps: (1) crushing the raw materials of the Chinese medicine composition, and subjecting the crushed materials to steam explosion treatment, wherein the conditions for the steam explosion are that the solvent is water, the mass ratio of water to the raw materials of the Chinese medicine composition is 10:1, the pressure is 1.3 MPa, the pressure is maintained for 90 to 100 seconds, and the steam explosion material is collected; (2) Mix the steam explosion material with water in a mass ratio of 1:10-18, soak, heat at 85°C for 20 hours, filter, collect the first filtrate, collect the filter residue, mix the filter residue with water 8 times the mass of the filter residue, steam for a second time for 15 hours, filter, and collect the second filtrate; (3) The first filtrate and the second filtrate are combined and concentrated to 55% of the volume of the filtrate. The concentrated solution is filtered and the filtrate is collected to obtain a Chinese medicine composition for relieving gouty arthritis. Example 2

[0026] 29g Corydalis yanhusuo, 17g Chuanxiong, 13g Notopterygium wilfordii, 18g Curcuma aromatica, 12g Aucklandia lappa, 14g Ginger stone, 16g Yuanshen, 19g Dioscorea opposita, 22g Cornus officinalis, and 26g Licorice.

[0027] The preparation method of the traditional Chinese medicine composition for relieving gouty arthritis comprises the following steps: (1) crushing the raw materials of the Chinese medicine composition, and subjecting the crushed materials to steam explosion treatment, wherein the conditions for the steam explosion are that the solvent is water, the mass ratio of water to the raw materials of the Chinese medicine composition is 10:1, the pressure is 1.3 MPa, the pressure is maintained for 90 to 100 seconds, and the steam explosion material is collected; (2) Mix the steam explosion material with water in a mass ratio of 1:10-18, soak, heat at 85°C for 20 hours, filter, collect the first filtrate, collect the filter residue, mix the filter residue with water 8 times the mass of the filter residue, steam for a second time for 15 hours, filter, and collect the second filtrate; (3) The first filtrate and the second filtrate are combined and concentrated to 55% of the volume of the filtrate. The concentrated solution is filtered and the filtrate is collected to obtain a Chinese medicine composition for relieving gouty arthritis. Example 3

[0028] The Chinese medicine composition includes the following components by mass: 26g of Corydalis yanhusuo, 15g of Chuanxiong, 11g of Notopterygium wilfordii, 14g of Curcuma aromatica, 8g of costusroot, 11g of ginger stone, 12g of Yuanshen, 14g of yam, 17g of Cornus officinalis, and 21g of liquorice.

[0029] The dosage form of the Chinese medicine composition is decoction.

[0030] The preparation method of the traditional Chinese medicine composition for relieving gouty arthritis comprises the following steps: (1) crushing the raw materials of the Chinese medicine composition, and subjecting the crushed materials to steam explosion treatment, wherein the conditions for the steam explosion are that the solvent is water, the mass ratio of water to the raw materials of the Chinese medicine composition is 10:1, the pressure is 1.3 MPa, the pressure is maintained for 90 to 100 seconds, and the steam explosion material is collected; (2) Mix the steam explosion material with water in a mass ratio of 1:10-18, soak, heat at 85°C for 20 hours, filter, collect the first filtrate, collect the filter residue, mix the filter residue with water 8 times the mass of the filter residue, steam for a second time for 15 hours, filter, and collect the second filtrate; (3) The first filtrate and the second filtrate are combined and concentrated to 55% of the volume of the filtrate. The concentrated solution is filtered and the filtrate is collected to obtain a Chinese medicine composition for relieving gouty arthritis.

[0031] The decoction of the Chinese medicine composition for relieving gouty arthritis prepared in Example 3 was selected as the experimental decoction, and the pharmacodynamics experiment and results of the Chinese medicine composition for treating gout of the present invention are as follows: 1. Experimental study of the Chinese herbal medicine composition for the treatment of gout on the purine-induced hyperuricemia model in mice 1. Experimental methods After one week of adaptive feeding, distilled water, distilled water, high-dose group, medium-dose group, and low-dose group were gavaged respectively; all were gavaged at 0.4 mL / 10 g body weight, 3 times a day, for 3 consecutive days.

[0032] One hour after the last intragastric administration, the normal control group was intraperitoneally injected with 0.1 mL / 10 g of saline solution, and the other five groups were intraperitoneally injected with 0.1 mL / 10 g of 10% xanthine suspension for modeling. After 0.5 hours, blood was collected by eyeball removal to detect uric acid levels and the results were statistically analyzed. Experimental results. Note: * indicates a significant difference compared with the normal control group P < 0.05; **Indicates a very significant difference compared with the normal control group P<0.01; △ indicates significant difference compared with the model control group P<0.05; △△ indicates a very significant difference compared with the model control group, P<0.01.

[0033] The experimental results showed that the mouse hyperuricemia model was successful, and the Chinese herbal composition for treating gout had a uric acid-lowering effect on the mouse hyperuricemia model, with the effects being stronger in the medium and high dose groups.

[0034] At the same time, in actual use, the Chinese medicine composition for relieving gouty arthritis of the present invention can have a good clinical therapeutic effect on acute gout and chronic gout, and the total clinical effective rate reaches 97.3%.

[0035] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for relieving gouty arthritis, characterized in that: The Chinese medicine composition comprises the following components by weight: 16 to 29 parts of Corydalis yanhusuo, 11 to 17 parts of chuanxiong, 7 to 13 parts of notopterygium wilfordii, 10 to 18 parts of curcuma, 5 to 12 parts of costusroot, 9 to 14 parts of ginger stone, 8 to 16 parts of Yuanshen, 11 to 19 parts of yam, 10 to 22 parts of cornus officinalis, and 12 to 26 parts of liquorice.

2. The Chinese medicine composition for relieving gouty arthritis according to claim 1, characterized in that: The Chinese medicine composition comprises the following components by weight: 26 parts of Corydalis yanhusuo, 15 parts of chuanxiong, 11 parts of notopterygium wilfordii, 14 parts of curcuma, 8 parts of costusroot, 11 parts of ginger stone, 12 parts of yuanshen, 14 parts of yam, 17 parts of cornus, and 21 parts of liquorice.

3. The Chinese medicine composition for relieving gouty arthritis according to claim 1, characterized in that: The dosage form of the Chinese medicine composition is decoction.

4. A method for preparing a Chinese medicine composition for relieving gouty arthritis according to any one of claims 1 to 3, characterized in that: The preparation method comprises the following steps: (1) crushing the raw materials of the Chinese medicine composition, performing steam explosion treatment on the crushed materials, and collecting the steam explosion materials; (2) mixing the steam explosion material with water in a mass ratio of 1:10 to 18, soaking, heating, filtering, collecting the first filtrate, collecting the filter residue, steaming the filter residue for a second time, filtering, and collecting the second filtrate; (3) The first filtrate and the second filtrate are combined, concentrated, filtered, and the filtrate is collected to obtain a Chinese medicine composition for relieving gouty arthritis.

5. The method for preparing the Chinese medicine composition for relieving gouty arthritis according to claim 4, characterized in that: The conditions for steam explosion in step (1) are as follows: the solvent is water, the mass ratio of water to the raw materials of the Chinese medicine composition is 10:1, the pressure is 1.3 MPa, and the pressure is maintained for 90 to 100 seconds.